-- dump date 20140619_123455 -- class Genbank::misc_feature -- table misc_feature_note -- id note 324831000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 324831000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 324831000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324831000004 Walker A motif; other site 324831000005 ATP binding site [chemical binding]; other site 324831000006 Walker B motif; other site 324831000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 324831000008 arginine finger; other site 324831000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 324831000010 DnaA box-binding interface [nucleotide binding]; other site 324831000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 324831000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 324831000013 putative DNA binding surface [nucleotide binding]; other site 324831000014 dimer interface [polypeptide binding]; other site 324831000015 beta-clamp/clamp loader binding surface; other site 324831000016 beta-clamp/translesion DNA polymerase binding surface; other site 324831000017 S4 domain; Region: S4_2; pfam13275 324831000018 recombination protein F; Reviewed; Region: recF; PRK00064 324831000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 324831000020 Walker A/P-loop; other site 324831000021 ATP binding site [chemical binding]; other site 324831000022 Q-loop/lid; other site 324831000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324831000024 ABC transporter signature motif; other site 324831000025 Walker B; other site 324831000026 D-loop; other site 324831000027 H-loop/switch region; other site 324831000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 324831000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324831000030 Mg2+ binding site [ion binding]; other site 324831000031 G-X-G motif; other site 324831000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 324831000033 anchoring element; other site 324831000034 dimer interface [polypeptide binding]; other site 324831000035 ATP binding site [chemical binding]; other site 324831000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 324831000037 active site 324831000038 putative metal-binding site [ion binding]; other site 324831000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 324831000040 DNA gyrase subunit A; Validated; Region: PRK05560 324831000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 324831000042 CAP-like domain; other site 324831000043 active site 324831000044 primary dimer interface [polypeptide binding]; other site 324831000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324831000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324831000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324831000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324831000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324831000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324831000051 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 324831000052 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 324831000053 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 324831000054 dimer interface [polypeptide binding]; other site 324831000055 ssDNA binding site [nucleotide binding]; other site 324831000056 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324831000057 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 324831000058 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 324831000059 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 324831000060 Cl binding site [ion binding]; other site 324831000061 oligomer interface [polypeptide binding]; other site 324831000062 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 324831000063 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 324831000064 DHH family; Region: DHH; pfam01368 324831000065 DHHA1 domain; Region: DHHA1; pfam02272 324831000066 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 324831000067 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 324831000068 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 324831000069 replicative DNA helicase; Region: DnaB; TIGR00665 324831000070 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 324831000071 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 324831000072 Walker A motif; other site 324831000073 ATP binding site [chemical binding]; other site 324831000074 Walker B motif; other site 324831000075 DNA binding loops [nucleotide binding] 324831000076 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324831000077 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 324831000078 nucleotide binding site [chemical binding]; other site 324831000079 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 324831000080 nucleophilic elbow; other site 324831000081 catalytic triad; other site 324831000082 MgtC family; Region: MgtC; pfam02308 324831000083 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 324831000084 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831000085 motif II; other site 324831000086 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324831000087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324831000088 non-specific DNA binding site [nucleotide binding]; other site 324831000089 salt bridge; other site 324831000090 sequence-specific DNA binding site [nucleotide binding]; other site 324831000091 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 324831000092 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324831000093 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324831000094 active site 324831000095 catalytic tetrad [active] 324831000096 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 324831000097 Sterol carrier protein domain; Region: SCP2_2; pfam13530 324831000098 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324831000099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324831000100 NAD(P) binding site [chemical binding]; other site 324831000101 active site 324831000102 Protein of unknown function (DUF975); Region: DUF975; pfam06161 324831000103 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 324831000104 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831000105 motif II; other site 324831000106 EDD domain protein, DegV family; Region: DegV; TIGR00762 324831000107 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 324831000108 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 324831000109 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 324831000110 G1 box; other site 324831000111 putative GEF interaction site [polypeptide binding]; other site 324831000112 GTP/Mg2+ binding site [chemical binding]; other site 324831000113 Switch I region; other site 324831000114 G2 box; other site 324831000115 G3 box; other site 324831000116 Switch II region; other site 324831000117 G4 box; other site 324831000118 G5 box; other site 324831000119 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 324831000120 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 324831000121 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 324831000122 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 324831000123 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 324831000124 oligomer interface [polypeptide binding]; other site 324831000125 Cl binding site [ion binding]; other site 324831000126 CsbD-like; Region: CsbD; cl17424 324831000127 Predicted membrane protein [Function unknown]; Region: COG2261 324831000128 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 324831000129 active site 324831000130 putative catalytic site [active] 324831000131 DNA binding site [nucleotide binding] 324831000132 putative phosphate binding site [ion binding]; other site 324831000133 metal binding site A [ion binding]; metal-binding site 324831000134 AP binding site [nucleotide binding]; other site 324831000135 metal binding site B [ion binding]; metal-binding site 324831000136 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 324831000137 PLD-like domain; Region: PLDc_2; pfam13091 324831000138 putative homodimer interface [polypeptide binding]; other site 324831000139 putative active site [active] 324831000140 catalytic site [active] 324831000141 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 324831000142 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324831000143 ATP binding site [chemical binding]; other site 324831000144 putative Mg++ binding site [ion binding]; other site 324831000145 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324831000146 nucleotide binding region [chemical binding]; other site 324831000147 ATP-binding site [chemical binding]; other site 324831000148 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 324831000149 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 324831000150 Putative serine esterase (DUF676); Region: DUF676; pfam05057 324831000151 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 324831000152 Domain of unknown function DUF20; Region: UPF0118; pfam01594 324831000153 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 324831000154 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 324831000155 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 324831000156 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324831000157 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 324831000158 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 324831000159 active site 324831000160 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 324831000161 catalytic triad [active] 324831000162 oxyanion hole [active] 324831000163 active site 324831000164 D-lactate dehydrogenase; Validated; Region: PRK08605 324831000165 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 324831000166 homodimer interface [polypeptide binding]; other site 324831000167 ligand binding site [chemical binding]; other site 324831000168 NAD binding site [chemical binding]; other site 324831000169 catalytic site [active] 324831000170 MucBP domain; Region: MucBP; pfam06458 324831000171 MucBP domain; Region: MucBP; pfam06458 324831000172 MucBP domain; Region: MucBP; pfam06458 324831000173 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 324831000174 MucBP domain; Region: MucBP; pfam06458 324831000175 MucBP domain; Region: MucBP; pfam06458 324831000176 MucBP domain; Region: MucBP; pfam06458 324831000177 MucBP domain; Region: MucBP; pfam06458 324831000178 MucBP domain; Region: MucBP; pfam06458 324831000179 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 324831000180 MucBP domain; Region: MucBP; pfam06458 324831000181 MucBP domain; Region: MucBP; pfam06458 324831000182 MucBP domain; Region: MucBP; pfam06458 324831000183 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 324831000184 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324831000185 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324831000186 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324831000187 dimerization interface [polypeptide binding]; other site 324831000188 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 324831000189 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 324831000190 L-aspartate oxidase; Provisional; Region: PRK06175 324831000191 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 324831000192 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 324831000193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324831000194 S-adenosylmethionine binding site [chemical binding]; other site 324831000195 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 324831000196 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 324831000197 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 324831000198 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 324831000199 active site 324831000200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831000201 putative substrate translocation pore; other site 324831000202 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 324831000203 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 324831000204 putative acyl-acceptor binding pocket; other site 324831000205 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 324831000206 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 324831000207 Ligand binding site; other site 324831000208 metal-binding site 324831000209 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 324831000210 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 324831000211 Ligand binding site; other site 324831000212 metal-binding site 324831000213 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 324831000214 Ligand binding site; other site 324831000215 metal-binding site 324831000216 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 324831000217 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 324831000218 putative acyl-acceptor binding pocket; other site 324831000219 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324831000220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324831000221 active site 324831000222 phosphorylation site [posttranslational modification] 324831000223 intermolecular recognition site; other site 324831000224 dimerization interface [polypeptide binding]; other site 324831000225 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324831000226 DNA binding site [nucleotide binding] 324831000227 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 324831000228 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324831000229 dimerization interface [polypeptide binding]; other site 324831000230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324831000231 putative active site [active] 324831000232 heme pocket [chemical binding]; other site 324831000233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324831000234 dimer interface [polypeptide binding]; other site 324831000235 phosphorylation site [posttranslational modification] 324831000236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324831000237 ATP binding site [chemical binding]; other site 324831000238 Mg2+ binding site [ion binding]; other site 324831000239 G-X-G motif; other site 324831000240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 324831000241 YycH protein; Region: YycH; pfam07435 324831000242 YycH protein; Region: YycI; pfam09648 324831000243 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 324831000244 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 324831000245 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 324831000246 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 324831000247 protein binding site [polypeptide binding]; other site 324831000248 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 324831000249 Cobalt transport protein; Region: CbiQ; cl00463 324831000250 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324831000251 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 324831000252 Walker A/P-loop; other site 324831000253 ATP binding site [chemical binding]; other site 324831000254 Q-loop/lid; other site 324831000255 ABC transporter signature motif; other site 324831000256 Walker B; other site 324831000257 D-loop; other site 324831000258 H-loop/switch region; other site 324831000259 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 324831000260 Walker A/P-loop; other site 324831000261 ATP binding site [chemical binding]; other site 324831000262 ABC transporter; Region: ABC_tran; pfam00005 324831000263 Q-loop/lid; other site 324831000264 ABC transporter signature motif; other site 324831000265 Walker B; other site 324831000266 D-loop; other site 324831000267 H-loop/switch region; other site 324831000268 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 324831000269 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324831000270 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324831000271 heat shock protein HtpX; Provisional; Region: PRK04897 324831000272 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 324831000273 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 324831000274 transmembrane helices; other site 324831000275 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324831000276 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 324831000277 DXD motif; other site 324831000278 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 324831000279 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324831000280 Zn2+ binding site [ion binding]; other site 324831000281 Mg2+ binding site [ion binding]; other site 324831000282 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 324831000283 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 324831000284 active site 324831000285 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 324831000286 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 324831000287 Walker A/P-loop; other site 324831000288 ATP binding site [chemical binding]; other site 324831000289 Q-loop/lid; other site 324831000290 ABC transporter signature motif; other site 324831000291 Walker B; other site 324831000292 D-loop; other site 324831000293 H-loop/switch region; other site 324831000294 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324831000295 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 324831000296 substrate binding pocket [chemical binding]; other site 324831000297 membrane-bound complex binding site; other site 324831000298 hinge residues; other site 324831000299 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 324831000300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831000301 dimer interface [polypeptide binding]; other site 324831000302 conserved gate region; other site 324831000303 putative PBP binding loops; other site 324831000304 ABC-ATPase subunit interface; other site 324831000305 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 324831000306 active site 324831000307 DNA binding site [nucleotide binding] 324831000308 Protein of unknown function, DUF488; Region: DUF488; cl01246 324831000309 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 324831000310 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 324831000311 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 324831000312 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 324831000313 DNA binding site [nucleotide binding] 324831000314 active site 324831000315 NAD-dependent deacetylase; Provisional; Region: PRK00481 324831000316 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 324831000317 NAD+ binding site [chemical binding]; other site 324831000318 substrate binding site [chemical binding]; other site 324831000319 putative Zn binding site [ion binding]; other site 324831000320 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 324831000321 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 324831000322 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 324831000323 putative active site [active] 324831000324 catalytic site [active] 324831000325 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 324831000326 putative active site [active] 324831000327 catalytic site [active] 324831000328 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 324831000329 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 324831000330 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 324831000331 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 324831000332 RNA/DNA hybrid binding site [nucleotide binding]; other site 324831000333 active site 324831000334 Predicted secreted protein [Function unknown]; Region: COG4086 324831000335 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 324831000336 putative glycosyl transferase; Provisional; Region: PRK10073 324831000337 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 324831000338 active site 324831000339 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 324831000340 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324831000341 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 324831000342 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 324831000343 CAAX protease self-immunity; Region: Abi; pfam02517 324831000344 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 324831000345 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324831000346 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324831000347 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 324831000348 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 324831000349 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 324831000350 ATP-grasp domain; Region: ATP-grasp_4; cl17255 324831000351 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324831000352 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 324831000353 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 324831000354 YibE/F-like protein; Region: YibE_F; pfam07907 324831000355 YibE/F-like protein; Region: YibE_F; pfam07907 324831000356 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 324831000357 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 324831000358 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 324831000359 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 324831000360 active site 324831000361 catalytic site [active] 324831000362 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 324831000363 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324831000364 Interdomain contacts; other site 324831000365 Cytokine receptor motif; other site 324831000366 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324831000367 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 324831000368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324831000369 DNA-binding site [nucleotide binding]; DNA binding site 324831000370 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 324831000371 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 324831000372 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 324831000373 dimer interface [polypeptide binding]; other site 324831000374 active site 324831000375 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 324831000376 putative active site [active] 324831000377 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 324831000378 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 324831000379 active site 324831000380 dimer interface [polypeptide binding]; other site 324831000381 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 324831000382 active site 324831000383 phosphorylation site [posttranslational modification] 324831000384 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 324831000385 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 324831000386 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 324831000387 active pocket/dimerization site; other site 324831000388 active site 324831000389 phosphorylation site [posttranslational modification] 324831000390 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324831000391 Double zinc ribbon; Region: DZR; pfam12773 324831000392 Bacterial lipoprotein; Region: DUF3642; pfam12182 324831000393 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 324831000394 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 324831000395 active site 324831000396 phosphorylation site [posttranslational modification] 324831000397 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 324831000398 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324831000399 DNA-binding site [nucleotide binding]; DNA binding site 324831000400 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 324831000401 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 324831000402 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 324831000403 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 324831000404 Ligand Binding Site [chemical binding]; other site 324831000405 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 324831000406 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324831000407 membrane-bound complex binding site; other site 324831000408 hinge residues; other site 324831000409 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 324831000410 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 324831000411 Walker A/P-loop; other site 324831000412 ATP binding site [chemical binding]; other site 324831000413 Q-loop/lid; other site 324831000414 ABC transporter signature motif; other site 324831000415 Walker B; other site 324831000416 D-loop; other site 324831000417 H-loop/switch region; other site 324831000418 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 324831000419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831000420 dimer interface [polypeptide binding]; other site 324831000421 conserved gate region; other site 324831000422 ABC-ATPase subunit interface; other site 324831000423 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 324831000424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831000425 dimer interface [polypeptide binding]; other site 324831000426 conserved gate region; other site 324831000427 putative PBP binding loops; other site 324831000428 ABC-ATPase subunit interface; other site 324831000429 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 324831000430 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324831000431 active site 324831000432 metal binding site [ion binding]; metal-binding site 324831000433 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 324831000434 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 324831000435 active site 324831000436 dimer interface [polypeptide binding]; other site 324831000437 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 324831000438 Ligand Binding Site [chemical binding]; other site 324831000439 Molecular Tunnel; other site 324831000440 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 324831000441 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 324831000442 ATP-grasp domain; Region: ATP-grasp_4; cl17255 324831000443 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 324831000444 ATP cone domain; Region: ATP-cone; pfam03477 324831000445 Class III ribonucleotide reductase; Region: RNR_III; cd01675 324831000446 effector binding site; other site 324831000447 active site 324831000448 Zn binding site [ion binding]; other site 324831000449 glycine loop; other site 324831000450 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 324831000451 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 324831000452 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 324831000453 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 324831000454 Uncharacterized conserved protein [Function unknown]; Region: COG2461 324831000455 Family of unknown function (DUF438); Region: DUF438; pfam04282 324831000456 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 324831000457 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 324831000458 Rib/alpha-like repeat; Region: Rib; cl07159 324831000459 MucBP domain; Region: MucBP; pfam06458 324831000460 MucBP domain; Region: MucBP; pfam06458 324831000461 MucBP domain; Region: MucBP; pfam06458 324831000462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831000463 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324831000464 putative substrate translocation pore; other site 324831000465 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858 324831000466 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 324831000467 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 324831000468 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 324831000469 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 324831000470 putative active site [active] 324831000471 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 324831000472 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 324831000473 putative substrate binding site [chemical binding]; other site 324831000474 putative ATP binding site [chemical binding]; other site 324831000475 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 324831000476 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 324831000477 active site 324831000478 P-loop; other site 324831000479 phosphorylation site [posttranslational modification] 324831000480 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 324831000481 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 324831000482 active site 324831000483 phosphorylation site [posttranslational modification] 324831000484 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 324831000485 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 324831000486 active site 324831000487 Zn binding site [ion binding]; other site 324831000488 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 324831000489 active site 324831000490 metal-binding site [ion binding] 324831000491 nucleotide-binding site [chemical binding]; other site 324831000492 K+ potassium transporter; Region: K_trans; pfam02705 324831000493 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 324831000494 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 324831000495 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 324831000496 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 324831000497 active site 324831000498 Bacterial SH3 domain; Region: SH3_5; pfam08460 324831000499 Bacterial SH3 domain; Region: SH3_5; pfam08460 324831000500 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 324831000501 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 324831000502 putative substrate binding site [chemical binding]; other site 324831000503 putative ATP binding site [chemical binding]; other site 324831000504 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 324831000505 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 324831000506 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 324831000507 TrkA-N domain; Region: TrkA_N; pfam02254 324831000508 TrkA-C domain; Region: TrkA_C; pfam02080 324831000509 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324831000510 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324831000511 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324831000512 PAS domain; Region: PAS_10; pfam13596 324831000513 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324831000514 catalytic core [active] 324831000515 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324831000516 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 324831000517 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 324831000518 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 324831000519 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 324831000520 Ligand binding site; other site 324831000521 Putative Catalytic site; other site 324831000522 DXD motif; other site 324831000523 Sugar transport protein; Region: Sugar_transport; pfam06800 324831000524 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 324831000525 active site 324831000526 catalytic residues [active] 324831000527 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 324831000528 membrane protein; Provisional; Region: PRK14411 324831000529 Sulfatase; Region: Sulfatase; cl17466 324831000530 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 324831000531 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 324831000532 active site 324831000533 HIGH motif; other site 324831000534 dimer interface [polypeptide binding]; other site 324831000535 KMSKS motif; other site 324831000536 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324831000537 RNA binding surface [nucleotide binding]; other site 324831000538 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 324831000539 trimer interface [polypeptide binding]; other site 324831000540 active site 324831000541 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 324831000542 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 324831000543 trimer interface [polypeptide binding]; other site 324831000544 active site 324831000545 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 324831000546 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 324831000547 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 324831000548 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 324831000549 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 324831000550 putative dimer interface [polypeptide binding]; other site 324831000551 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 324831000552 beta-galactosidase; Region: BGL; TIGR03356 324831000553 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 324831000554 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 324831000555 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 324831000556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324831000557 DNA-binding site [nucleotide binding]; DNA binding site 324831000558 UTRA domain; Region: UTRA; pfam07702 324831000559 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 324831000560 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 324831000561 beta-galactosidase; Region: BGL; TIGR03356 324831000562 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 324831000563 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324831000564 DNA-binding site [nucleotide binding]; DNA binding site 324831000565 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 324831000566 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 324831000567 methionine cluster; other site 324831000568 active site 324831000569 phosphorylation site [posttranslational modification] 324831000570 metal binding site [ion binding]; metal-binding site 324831000571 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 324831000572 active site 324831000573 P-loop; other site 324831000574 phosphorylation site [posttranslational modification] 324831000575 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 324831000576 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 324831000577 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 324831000578 beta-galactosidase; Region: BGL; TIGR03356 324831000579 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324831000580 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 324831000581 nucleotide binding site [chemical binding]; other site 324831000582 CAAX protease self-immunity; Region: Abi; pfam02517 324831000583 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 324831000584 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 324831000585 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 324831000586 active site 324831000587 HIGH motif; other site 324831000588 dimer interface [polypeptide binding]; other site 324831000589 KMSKS motif; other site 324831000590 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 324831000591 catalytic motif [active] 324831000592 Zn binding site [ion binding]; other site 324831000593 Repair protein; Region: Repair_PSII; cl01535 324831000594 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 324831000595 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 324831000596 active site 324831000597 HIGH motif; other site 324831000598 KMSKS motif; other site 324831000599 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 324831000600 tRNA binding surface [nucleotide binding]; other site 324831000601 anticodon binding site; other site 324831000602 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 324831000603 dimer interface [polypeptide binding]; other site 324831000604 putative tRNA-binding site [nucleotide binding]; other site 324831000605 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 324831000606 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 324831000607 active site 324831000608 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 324831000609 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 324831000610 putative active site [active] 324831000611 putative metal binding site [ion binding]; other site 324831000612 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 324831000613 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 324831000614 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 324831000615 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 324831000616 pur operon repressor; Provisional; Region: PRK09213 324831000617 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 324831000618 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324831000619 active site 324831000620 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 324831000621 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 324831000622 Substrate binding site; other site 324831000623 Mg++ binding site; other site 324831000624 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 324831000625 active site 324831000626 substrate binding site [chemical binding]; other site 324831000627 CoA binding site [chemical binding]; other site 324831000628 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 324831000629 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 324831000630 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324831000631 active site 324831000632 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324831000633 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324831000634 DNA binding site [nucleotide binding] 324831000635 domain linker motif; other site 324831000636 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324831000637 ligand binding site [chemical binding]; other site 324831000638 dimerization interface [polypeptide binding]; other site 324831000639 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 324831000640 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 324831000641 Ca binding site [ion binding]; other site 324831000642 active site 324831000643 catalytic site [active] 324831000644 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 324831000645 homodimer interface [polypeptide binding]; other site 324831000646 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 324831000647 active site 324831000648 homodimer interface [polypeptide binding]; other site 324831000649 catalytic site [active] 324831000650 maltose phosphorylase; Provisional; Region: PRK13807 324831000651 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 324831000652 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 324831000653 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 324831000654 beta-phosphoglucomutase; Region: bPGM; TIGR01990 324831000655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831000656 motif II; other site 324831000657 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 324831000658 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 324831000659 Walker A/P-loop; other site 324831000660 ATP binding site [chemical binding]; other site 324831000661 Q-loop/lid; other site 324831000662 ABC transporter signature motif; other site 324831000663 Walker B; other site 324831000664 D-loop; other site 324831000665 H-loop/switch region; other site 324831000666 TOBE domain; Region: TOBE_2; pfam08402 324831000667 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 324831000668 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324831000669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831000670 dimer interface [polypeptide binding]; other site 324831000671 conserved gate region; other site 324831000672 putative PBP binding loops; other site 324831000673 ABC-ATPase subunit interface; other site 324831000674 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324831000675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831000676 dimer interface [polypeptide binding]; other site 324831000677 conserved gate region; other site 324831000678 putative PBP binding loops; other site 324831000679 ABC-ATPase subunit interface; other site 324831000680 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 324831000681 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 324831000682 Ca binding site [ion binding]; other site 324831000683 active site 324831000684 catalytic site [active] 324831000685 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 324831000686 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 324831000687 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324831000688 Zn2+ binding site [ion binding]; other site 324831000689 Mg2+ binding site [ion binding]; other site 324831000690 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 324831000691 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 324831000692 CTP synthetase; Validated; Region: pyrG; PRK05380 324831000693 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 324831000694 Catalytic site [active] 324831000695 active site 324831000696 UTP binding site [chemical binding]; other site 324831000697 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 324831000698 active site 324831000699 putative oxyanion hole; other site 324831000700 catalytic triad [active] 324831000701 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 324831000702 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 324831000703 hinge; other site 324831000704 active site 324831000705 xanthine permease; Region: pbuX; TIGR03173 324831000706 Sulfate transporter family; Region: Sulfate_transp; pfam00916 324831000707 xanthine phosphoribosyltransferase; Validated; Region: PRK09219 324831000708 GMP synthase; Reviewed; Region: guaA; PRK00074 324831000709 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 324831000710 AMP/PPi binding site [chemical binding]; other site 324831000711 candidate oxyanion hole; other site 324831000712 catalytic triad [active] 324831000713 potential glutamine specificity residues [chemical binding]; other site 324831000714 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 324831000715 ATP Binding subdomain [chemical binding]; other site 324831000716 Ligand Binding sites [chemical binding]; other site 324831000717 Dimerization subdomain; other site 324831000718 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324831000719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324831000720 non-specific DNA binding site [nucleotide binding]; other site 324831000721 salt bridge; other site 324831000722 sequence-specific DNA binding site [nucleotide binding]; other site 324831000723 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 324831000724 Fic/DOC family; Region: Fic; cl00960 324831000725 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324831000726 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324831000727 WHG domain; Region: WHG; pfam13305 324831000728 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 324831000729 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 324831000730 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 324831000731 Cache domain; Region: Cache_1; pfam02743 324831000732 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 324831000733 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 324831000734 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 324831000735 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 324831000736 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 324831000737 DNA binding site [nucleotide binding] 324831000738 active site 324831000739 formyl-coenzyme A transferase; Provisional; Region: PRK05398 324831000740 CoA-transferase family III; Region: CoA_transf_3; pfam02515 324831000741 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 324831000742 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 324831000743 PYR/PP interface [polypeptide binding]; other site 324831000744 dimer interface [polypeptide binding]; other site 324831000745 TPP binding site [chemical binding]; other site 324831000746 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 324831000747 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 324831000748 TPP-binding site; other site 324831000749 dimer interface [polypeptide binding]; other site 324831000750 Membrane transport protein; Region: Mem_trans; cl09117 324831000751 Membrane transport protein; Region: Mem_trans; cl09117 324831000752 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 324831000753 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324831000754 Peptidase family C69; Region: Peptidase_C69; pfam03577 324831000755 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 324831000756 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 324831000757 dimer interface [polypeptide binding]; other site 324831000758 active site 324831000759 glycine-pyridoxal phosphate binding site [chemical binding]; other site 324831000760 folate binding site [chemical binding]; other site 324831000761 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 324831000762 Melibiase; Region: Melibiase; pfam02065 324831000763 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 324831000764 zinc binding site [ion binding]; other site 324831000765 putative ligand binding site [chemical binding]; other site 324831000766 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 324831000767 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 324831000768 TM-ABC transporter signature motif; other site 324831000769 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 324831000770 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324831000771 Walker A/P-loop; other site 324831000772 ATP binding site [chemical binding]; other site 324831000773 Q-loop/lid; other site 324831000774 ABC transporter signature motif; other site 324831000775 Walker B; other site 324831000776 D-loop; other site 324831000777 H-loop/switch region; other site 324831000778 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 324831000779 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 324831000780 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 324831000781 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 324831000782 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324831000783 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324831000784 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 324831000785 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 324831000786 ATP binding site [chemical binding]; other site 324831000787 Mg++ binding site [ion binding]; other site 324831000788 motif III; other site 324831000789 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324831000790 nucleotide binding region [chemical binding]; other site 324831000791 ATP-binding site [chemical binding]; other site 324831000792 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 324831000793 alanine racemase; Reviewed; Region: alr; PRK00053 324831000794 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 324831000795 active site 324831000796 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 324831000797 dimer interface [polypeptide binding]; other site 324831000798 substrate binding site [chemical binding]; other site 324831000799 catalytic residues [active] 324831000800 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 324831000801 FOG: CBS domain [General function prediction only]; Region: COG0517 324831000802 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 324831000803 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 324831000804 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324831000805 NAD binding site [chemical binding]; other site 324831000806 dimer interface [polypeptide binding]; other site 324831000807 substrate binding site [chemical binding]; other site 324831000808 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 324831000809 putative active site [active] 324831000810 catalytic residue [active] 324831000811 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 324831000812 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 324831000813 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324831000814 ATP binding site [chemical binding]; other site 324831000815 putative Mg++ binding site [ion binding]; other site 324831000816 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324831000817 nucleotide binding region [chemical binding]; other site 324831000818 ATP-binding site [chemical binding]; other site 324831000819 TRCF domain; Region: TRCF; pfam03461 324831000820 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324831000821 RNA binding surface [nucleotide binding]; other site 324831000822 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 324831000823 Septum formation initiator; Region: DivIC; pfam04977 324831000824 hypothetical protein; Provisional; Region: PRK08582 324831000825 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 324831000826 RNA binding site [nucleotide binding]; other site 324831000827 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 324831000828 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 324831000829 Ligand Binding Site [chemical binding]; other site 324831000830 FtsH Extracellular; Region: FtsH_ext; pfam06480 324831000831 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 324831000832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324831000833 Walker A motif; other site 324831000834 ATP binding site [chemical binding]; other site 324831000835 Walker B motif; other site 324831000836 arginine finger; other site 324831000837 Peptidase family M41; Region: Peptidase_M41; pfam01434 324831000838 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 324831000839 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 324831000840 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 324831000841 dimerization interface [polypeptide binding]; other site 324831000842 domain crossover interface; other site 324831000843 redox-dependent activation switch; other site 324831000844 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 324831000845 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 324831000846 FMN binding site [chemical binding]; other site 324831000847 active site 324831000848 catalytic residues [active] 324831000849 substrate binding site [chemical binding]; other site 324831000850 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 324831000851 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 324831000852 dimer interface [polypeptide binding]; other site 324831000853 putative anticodon binding site; other site 324831000854 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 324831000855 motif 1; other site 324831000856 active site 324831000857 motif 2; other site 324831000858 motif 3; other site 324831000859 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 324831000860 Clp amino terminal domain; Region: Clp_N; pfam02861 324831000861 Clp amino terminal domain; Region: Clp_N; pfam02861 324831000862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324831000863 Walker A motif; other site 324831000864 ATP binding site [chemical binding]; other site 324831000865 Walker B motif; other site 324831000866 arginine finger; other site 324831000867 UvrB/uvrC motif; Region: UVR; pfam02151 324831000868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324831000869 Walker A motif; other site 324831000870 ATP binding site [chemical binding]; other site 324831000871 Walker B motif; other site 324831000872 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 324831000873 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 324831000874 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 324831000875 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 324831000876 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 324831000877 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 324831000878 RPB1 interaction site [polypeptide binding]; other site 324831000879 RPB10 interaction site [polypeptide binding]; other site 324831000880 RPB11 interaction site [polypeptide binding]; other site 324831000881 RPB3 interaction site [polypeptide binding]; other site 324831000882 RPB12 interaction site [polypeptide binding]; other site 324831000883 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 324831000884 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 324831000885 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 324831000886 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 324831000887 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 324831000888 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 324831000889 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 324831000890 DNA binding site [nucleotide binding] 324831000891 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 324831000892 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 324831000893 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 324831000894 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 324831000895 S17 interaction site [polypeptide binding]; other site 324831000896 S8 interaction site; other site 324831000897 16S rRNA interaction site [nucleotide binding]; other site 324831000898 streptomycin interaction site [chemical binding]; other site 324831000899 23S rRNA interaction site [nucleotide binding]; other site 324831000900 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 324831000901 30S ribosomal protein S7; Validated; Region: PRK05302 324831000902 elongation factor G; Reviewed; Region: PRK12739 324831000903 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 324831000904 G1 box; other site 324831000905 putative GEF interaction site [polypeptide binding]; other site 324831000906 GTP/Mg2+ binding site [chemical binding]; other site 324831000907 Switch I region; other site 324831000908 G2 box; other site 324831000909 G3 box; other site 324831000910 Switch II region; other site 324831000911 G4 box; other site 324831000912 G5 box; other site 324831000913 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 324831000914 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 324831000915 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 324831000916 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 324831000917 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 324831000918 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 324831000919 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 324831000920 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 324831000921 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 324831000922 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 324831000923 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 324831000924 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 324831000925 putative translocon binding site; other site 324831000926 protein-rRNA interface [nucleotide binding]; other site 324831000927 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 324831000928 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 324831000929 G-X-X-G motif; other site 324831000930 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 324831000931 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 324831000932 23S rRNA interface [nucleotide binding]; other site 324831000933 5S rRNA interface [nucleotide binding]; other site 324831000934 putative antibiotic binding site [chemical binding]; other site 324831000935 L25 interface [polypeptide binding]; other site 324831000936 L27 interface [polypeptide binding]; other site 324831000937 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 324831000938 23S rRNA interface [nucleotide binding]; other site 324831000939 putative translocon interaction site; other site 324831000940 signal recognition particle (SRP54) interaction site; other site 324831000941 L23 interface [polypeptide binding]; other site 324831000942 trigger factor interaction site; other site 324831000943 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 324831000944 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 324831000945 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 324831000946 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 324831000947 RNA binding site [nucleotide binding]; other site 324831000948 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 324831000949 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 324831000950 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 324831000951 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 324831000952 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 324831000953 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 324831000954 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 324831000955 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 324831000956 23S rRNA interface [nucleotide binding]; other site 324831000957 L21e interface [polypeptide binding]; other site 324831000958 5S rRNA interface [nucleotide binding]; other site 324831000959 L27 interface [polypeptide binding]; other site 324831000960 L5 interface [polypeptide binding]; other site 324831000961 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 324831000962 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 324831000963 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 324831000964 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 324831000965 23S rRNA binding site [nucleotide binding]; other site 324831000966 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 324831000967 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 324831000968 SecY translocase; Region: SecY; pfam00344 324831000969 adenylate kinase; Reviewed; Region: adk; PRK00279 324831000970 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 324831000971 AMP-binding site [chemical binding]; other site 324831000972 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 324831000973 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 324831000974 rRNA binding site [nucleotide binding]; other site 324831000975 predicted 30S ribosome binding site; other site 324831000976 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 324831000977 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 324831000978 30S ribosomal protein S13; Region: bact_S13; TIGR03631 324831000979 30S ribosomal protein S11; Validated; Region: PRK05309 324831000980 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 324831000981 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 324831000982 alphaNTD homodimer interface [polypeptide binding]; other site 324831000983 alphaNTD - beta interaction site [polypeptide binding]; other site 324831000984 alphaNTD - beta' interaction site [polypeptide binding]; other site 324831000985 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 324831000986 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 324831000987 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13640 324831000988 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 324831000989 Walker A/P-loop; other site 324831000990 ATP binding site [chemical binding]; other site 324831000991 Q-loop/lid; other site 324831000992 ABC transporter signature motif; other site 324831000993 Walker B; other site 324831000994 D-loop; other site 324831000995 H-loop/switch region; other site 324831000996 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13641 324831000997 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 324831000998 Walker A/P-loop; other site 324831000999 ATP binding site [chemical binding]; other site 324831001000 Q-loop/lid; other site 324831001001 ABC transporter signature motif; other site 324831001002 Walker B; other site 324831001003 D-loop; other site 324831001004 H-loop/switch region; other site 324831001005 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 324831001006 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 324831001007 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 324831001008 dimerization interface 3.5A [polypeptide binding]; other site 324831001009 active site 324831001010 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 324831001011 23S rRNA interface [nucleotide binding]; other site 324831001012 L3 interface [polypeptide binding]; other site 324831001013 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 324831001014 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 324831001015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324831001016 NAD(P) binding site [chemical binding]; other site 324831001017 active site 324831001018 DJ-1 family protein; Region: not_thiJ; TIGR01383 324831001019 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 324831001020 conserved cys residue [active] 324831001021 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324831001022 catalytic core [active] 324831001023 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324831001024 dimerization interface [polypeptide binding]; other site 324831001025 putative DNA binding site [nucleotide binding]; other site 324831001026 putative Zn2+ binding site [ion binding]; other site 324831001027 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 324831001028 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 324831001029 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324831001030 catalytic core [active] 324831001031 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324831001032 AAA domain; Region: AAA_33; pfam13671 324831001033 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 324831001034 trimer interface [polypeptide binding]; other site 324831001035 active site 324831001036 G bulge; other site 324831001037 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 324831001038 trimer interface [polypeptide binding]; other site 324831001039 active site 324831001040 DNA repair protein RadA; Provisional; Region: PRK11823 324831001041 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 324831001042 Walker A motif/ATP binding site; other site 324831001043 ATP binding site [chemical binding]; other site 324831001044 Walker B motif; other site 324831001045 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 324831001046 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 324831001047 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 324831001048 active site 324831001049 HIGH motif; other site 324831001050 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 324831001051 active site 324831001052 KMSKS motif; other site 324831001053 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 324831001054 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 324831001055 active site 324831001056 HIGH motif; other site 324831001057 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 324831001058 KMSKS motif; other site 324831001059 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 324831001060 tRNA binding surface [nucleotide binding]; other site 324831001061 anticodon binding site; other site 324831001062 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 324831001063 active site 324831001064 metal binding site [ion binding]; metal-binding site 324831001065 dimerization interface [polypeptide binding]; other site 324831001066 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 324831001067 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 324831001068 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 324831001069 transcriptional antiterminator BglG; Provisional; Region: PRK09772 324831001070 CAT RNA binding domain; Region: CAT_RBD; smart01061 324831001071 PRD domain; Region: PRD; pfam00874 324831001072 PRD domain; Region: PRD; pfam00874 324831001073 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 324831001074 methionine cluster; other site 324831001075 active site 324831001076 phosphorylation site [posttranslational modification] 324831001077 metal binding site [ion binding]; metal-binding site 324831001078 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 324831001079 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 324831001080 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 324831001081 active site 324831001082 P-loop; other site 324831001083 phosphorylation site [posttranslational modification] 324831001084 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 324831001085 beta-galactosidase; Region: BGL; TIGR03356 324831001086 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 324831001087 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 324831001088 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 324831001089 N- and C-terminal domain interface [polypeptide binding]; other site 324831001090 active site 324831001091 catalytic site [active] 324831001092 metal binding site [ion binding]; metal-binding site 324831001093 carbohydrate binding site [chemical binding]; other site 324831001094 ATP binding site [chemical binding]; other site 324831001095 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 324831001096 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 324831001097 TPP-binding site; other site 324831001098 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 324831001099 PYR/PP interface [polypeptide binding]; other site 324831001100 dimer interface [polypeptide binding]; other site 324831001101 TPP binding site [chemical binding]; other site 324831001102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831001103 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324831001104 putative substrate translocation pore; other site 324831001105 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 324831001106 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 324831001107 substrate binding pocket [chemical binding]; other site 324831001108 chain length determination region; other site 324831001109 substrate-Mg2+ binding site; other site 324831001110 catalytic residues [active] 324831001111 aspartate-rich region 1; other site 324831001112 active site lid residues [active] 324831001113 aspartate-rich region 2; other site 324831001114 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 324831001115 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 324831001116 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 324831001117 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 324831001118 putative homodimer interface [polypeptide binding]; other site 324831001119 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 324831001120 heterodimer interface [polypeptide binding]; other site 324831001121 homodimer interface [polypeptide binding]; other site 324831001122 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 324831001123 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 324831001124 23S rRNA interface [nucleotide binding]; other site 324831001125 L7/L12 interface [polypeptide binding]; other site 324831001126 putative thiostrepton binding site; other site 324831001127 L25 interface [polypeptide binding]; other site 324831001128 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 324831001129 mRNA/rRNA interface [nucleotide binding]; other site 324831001130 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 324831001131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831001132 dimer interface [polypeptide binding]; other site 324831001133 conserved gate region; other site 324831001134 putative PBP binding loops; other site 324831001135 ABC-ATPase subunit interface; other site 324831001136 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324831001137 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324831001138 Walker A/P-loop; other site 324831001139 ATP binding site [chemical binding]; other site 324831001140 Q-loop/lid; other site 324831001141 ABC transporter signature motif; other site 324831001142 Walker B; other site 324831001143 D-loop; other site 324831001144 H-loop/switch region; other site 324831001145 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 324831001146 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324831001147 substrate binding pocket [chemical binding]; other site 324831001148 membrane-bound complex binding site; other site 324831001149 hinge residues; other site 324831001150 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 324831001151 23S rRNA interface [nucleotide binding]; other site 324831001152 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 324831001153 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 324831001154 core dimer interface [polypeptide binding]; other site 324831001155 peripheral dimer interface [polypeptide binding]; other site 324831001156 L10 interface [polypeptide binding]; other site 324831001157 L11 interface [polypeptide binding]; other site 324831001158 putative EF-Tu interaction site [polypeptide binding]; other site 324831001159 putative EF-G interaction site [polypeptide binding]; other site 324831001160 Ion transport protein; Region: Ion_trans; pfam00520 324831001161 Ion channel; Region: Ion_trans_2; pfam07885 324831001162 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324831001163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324831001164 S-adenosylmethionine binding site [chemical binding]; other site 324831001165 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 324831001166 nucleoside/Zn binding site; other site 324831001167 dimer interface [polypeptide binding]; other site 324831001168 catalytic motif [active] 324831001169 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 324831001170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324831001171 Walker A motif; other site 324831001172 ATP binding site [chemical binding]; other site 324831001173 Walker B motif; other site 324831001174 hypothetical protein; Validated; Region: PRK00153 324831001175 recombination protein RecR; Reviewed; Region: recR; PRK00076 324831001176 RecR protein; Region: RecR; pfam02132 324831001177 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 324831001178 putative active site [active] 324831001179 putative metal-binding site [ion binding]; other site 324831001180 tetramer interface [polypeptide binding]; other site 324831001181 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 324831001182 thymidylate kinase; Validated; Region: tmk; PRK00698 324831001183 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 324831001184 TMP-binding site; other site 324831001185 ATP-binding site [chemical binding]; other site 324831001186 Protein of unknown function (DUF970); Region: DUF970; pfam06153 324831001187 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 324831001188 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 324831001189 Predicted methyltransferases [General function prediction only]; Region: COG0313 324831001190 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 324831001191 putative SAM binding site [chemical binding]; other site 324831001192 putative homodimer interface [polypeptide binding]; other site 324831001193 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 324831001194 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 324831001195 active site 324831001196 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 324831001197 active site 2 [active] 324831001198 active site 1 [active] 324831001199 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 324831001200 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 324831001201 Glycoprotease family; Region: Peptidase_M22; pfam00814 324831001202 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 324831001203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324831001204 Coenzyme A binding pocket [chemical binding]; other site 324831001205 UGMP family protein; Validated; Region: PRK09604 324831001206 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 324831001207 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 324831001208 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 324831001209 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 324831001210 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 324831001211 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 324831001212 Cl- selectivity filter; other site 324831001213 Cl- binding residues [ion binding]; other site 324831001214 pore gating glutamate residue; other site 324831001215 dimer interface [polypeptide binding]; other site 324831001216 H+/Cl- coupling transport residue; other site 324831001217 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 324831001218 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 324831001219 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 324831001220 active site 324831001221 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 324831001222 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 324831001223 GDP-binding site [chemical binding]; other site 324831001224 ACT binding site; other site 324831001225 IMP binding site; other site 324831001226 adenylosuccinate lyase; Provisional; Region: PRK07492 324831001227 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 324831001228 tetramer interface [polypeptide binding]; other site 324831001229 active site 324831001230 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 324831001231 active site 324831001232 Ap4A binding cleft/pocket [chemical binding]; other site 324831001233 P4 phosphate binding site; other site 324831001234 nudix motif; other site 324831001235 putative P2/P3 phosphate binding site [ion binding]; other site 324831001236 RelB antitoxin; Region: RelB; cl01171 324831001237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 324831001238 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 324831001239 CoA-transferase family III; Region: CoA_transf_3; pfam02515 324831001240 Cupin domain; Region: Cupin_2; pfam07883 324831001241 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324831001242 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 324831001243 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 324831001244 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 324831001245 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 324831001246 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 324831001247 active site turn [active] 324831001248 phosphorylation site [posttranslational modification] 324831001249 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 324831001250 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 324831001251 HPr interaction site; other site 324831001252 glycerol kinase (GK) interaction site [polypeptide binding]; other site 324831001253 active site 324831001254 phosphorylation site [posttranslational modification] 324831001255 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 324831001256 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 324831001257 substrate binding [chemical binding]; other site 324831001258 active site 324831001259 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 324831001260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324831001261 non-specific DNA binding site [nucleotide binding]; other site 324831001262 salt bridge; other site 324831001263 sequence-specific DNA binding site [nucleotide binding]; other site 324831001264 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324831001265 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324831001266 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324831001267 ABC transporter; Region: ABC_tran_2; pfam12848 324831001268 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324831001269 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 324831001270 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 324831001271 CoA binding domain; Region: CoA_binding; pfam02629 324831001272 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 324831001273 LytTr DNA-binding domain; Region: LytTR; smart00850 324831001274 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 324831001275 oligomerisation interface [polypeptide binding]; other site 324831001276 mobile loop; other site 324831001277 roof hairpin; other site 324831001278 chaperonin GroL; Region: GroEL; TIGR02348 324831001279 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 324831001280 ring oligomerisation interface [polypeptide binding]; other site 324831001281 ATP/Mg binding site [chemical binding]; other site 324831001282 stacking interactions; other site 324831001283 hinge regions; other site 324831001284 MucBP domain; Region: MucBP; pfam06458 324831001285 MucBP domain; Region: MucBP; pfam06458 324831001286 MucBP domain; Region: MucBP; pfam06458 324831001287 MucBP domain; Region: MucBP; pfam06458 324831001288 Rib/alpha-like repeat; Region: Rib; pfam08428 324831001289 Rib/alpha-like repeat; Region: Rib; pfam08428 324831001290 Rib/alpha-like repeat; Region: Rib; pfam08428 324831001291 Rib/alpha-like repeat; Region: Rib; pfam08428 324831001292 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 324831001293 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324831001294 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 324831001295 Walker A/P-loop; other site 324831001296 ATP binding site [chemical binding]; other site 324831001297 Q-loop/lid; other site 324831001298 ABC transporter signature motif; other site 324831001299 Walker B; other site 324831001300 D-loop; other site 324831001301 H-loop/switch region; other site 324831001302 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 324831001303 MutS domain I; Region: MutS_I; pfam01624 324831001304 MutS domain II; Region: MutS_II; pfam05188 324831001305 MutS domain III; Region: MutS_III; pfam05192 324831001306 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 324831001307 Walker A/P-loop; other site 324831001308 ATP binding site [chemical binding]; other site 324831001309 Q-loop/lid; other site 324831001310 ABC transporter signature motif; other site 324831001311 Walker B; other site 324831001312 D-loop; other site 324831001313 H-loop/switch region; other site 324831001314 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 324831001315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324831001316 ATP binding site [chemical binding]; other site 324831001317 Mg2+ binding site [ion binding]; other site 324831001318 G-X-G motif; other site 324831001319 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 324831001320 ATP binding site [chemical binding]; other site 324831001321 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 324831001322 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 324831001323 RuvA N terminal domain; Region: RuvA_N; pfam01330 324831001324 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 324831001325 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 324831001326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324831001327 Walker A motif; other site 324831001328 ATP binding site [chemical binding]; other site 324831001329 Walker B motif; other site 324831001330 arginine finger; other site 324831001331 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 324831001332 Preprotein translocase subunit; Region: YajC; pfam02699 324831001333 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 324831001334 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 324831001335 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 324831001336 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 324831001337 active site 324831001338 DNA polymerase IV; Validated; Region: PRK02406 324831001339 DNA binding site [nucleotide binding] 324831001340 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 324831001341 DHH family; Region: DHH; pfam01368 324831001342 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 324831001343 DEAD-like helicases superfamily; Region: DEXDc; smart00487 324831001344 ATP binding site [chemical binding]; other site 324831001345 putative Mg++ binding site [ion binding]; other site 324831001346 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324831001347 nucleotide binding region [chemical binding]; other site 324831001348 ATP-binding site [chemical binding]; other site 324831001349 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 324831001350 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 324831001351 motif 1; other site 324831001352 active site 324831001353 motif 2; other site 324831001354 motif 3; other site 324831001355 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 324831001356 DHHA1 domain; Region: DHHA1; pfam02272 324831001357 hypothetical protein; Provisional; Region: PRK05473 324831001358 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 324831001359 hypothetical protein; Provisional; Region: PRK13678 324831001360 Colicin V production protein; Region: Colicin_V; pfam02674 324831001361 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 324831001362 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 324831001363 MutS domain III; Region: MutS_III; pfam05192 324831001364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324831001365 Walker A/P-loop; other site 324831001366 ATP binding site [chemical binding]; other site 324831001367 Q-loop/lid; other site 324831001368 ABC transporter signature motif; other site 324831001369 Walker B; other site 324831001370 D-loop; other site 324831001371 H-loop/switch region; other site 324831001372 Smr domain; Region: Smr; pfam01713 324831001373 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 324831001374 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 324831001375 catalytic residues [active] 324831001376 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 324831001377 glutamate racemase; Provisional; Region: PRK00865 324831001378 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 324831001379 active site 324831001380 dimerization interface [polypeptide binding]; other site 324831001381 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 324831001382 propionate/acetate kinase; Provisional; Region: PRK12379 324831001383 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 324831001384 Mechanosensitive ion channel; Region: MS_channel; pfam00924 324831001385 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 324831001386 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 324831001387 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 324831001388 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 324831001389 active site 324831001390 catabolite control protein A; Region: ccpA; TIGR01481 324831001391 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324831001392 DNA binding site [nucleotide binding] 324831001393 domain linker motif; other site 324831001394 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 324831001395 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324831001396 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324831001397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324831001398 Walker A/P-loop; other site 324831001399 ATP binding site [chemical binding]; other site 324831001400 Q-loop/lid; other site 324831001401 ABC transporter signature motif; other site 324831001402 Walker B; other site 324831001403 D-loop; other site 324831001404 H-loop/switch region; other site 324831001405 Transglycosylase; Region: Transgly; pfam00912 324831001406 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 324831001407 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 324831001408 dipeptidase PepV; Reviewed; Region: PRK07318 324831001409 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 324831001410 active site 324831001411 metal binding site [ion binding]; metal-binding site 324831001412 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 324831001413 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 324831001414 active site 324831001415 catalytic site [active] 324831001416 metal binding site [ion binding]; metal-binding site 324831001417 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 324831001418 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 324831001419 active site 324831001420 metal binding site [ion binding]; metal-binding site 324831001421 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 324831001422 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 324831001423 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 324831001424 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831001425 active site 324831001426 motif I; other site 324831001427 motif II; other site 324831001428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831001429 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 324831001430 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 324831001431 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 324831001432 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 324831001433 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 324831001434 general stress protein 13; Validated; Region: PRK08059 324831001435 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 324831001436 RNA binding site [nucleotide binding]; other site 324831001437 S-adenosylmethionine synthetase; Validated; Region: PRK05250 324831001438 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 324831001439 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 324831001440 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 324831001441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831001442 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324831001443 putative substrate translocation pore; other site 324831001444 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 324831001445 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 324831001446 active site 324831001447 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 324831001448 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 324831001449 HIGH motif; other site 324831001450 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 324831001451 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 324831001452 active site 324831001453 KMSKS motif; other site 324831001454 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 324831001455 tRNA binding surface [nucleotide binding]; other site 324831001456 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 324831001457 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 324831001458 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 324831001459 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 324831001460 putative substrate binding site [chemical binding]; other site 324831001461 putative ATP binding site [chemical binding]; other site 324831001462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 324831001463 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 324831001464 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 324831001465 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 324831001466 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 324831001467 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 324831001468 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 324831001469 active site 324831001470 HIGH motif; other site 324831001471 KMSK motif region; other site 324831001472 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 324831001473 tRNA binding surface [nucleotide binding]; other site 324831001474 anticodon binding site; other site 324831001475 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 324831001476 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 324831001477 intersubunit interface [polypeptide binding]; other site 324831001478 active site 324831001479 zinc binding site [ion binding]; other site 324831001480 Na+ binding site [ion binding]; other site 324831001481 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324831001482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324831001483 Coenzyme A binding pocket [chemical binding]; other site 324831001484 Uncharacterized conserved protein [Function unknown]; Region: COG1359 324831001485 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324831001486 active site 324831001487 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 324831001488 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 324831001489 catalytic triad [active] 324831001490 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 324831001491 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324831001492 NAD(P) binding site [chemical binding]; other site 324831001493 putative active site [active] 324831001494 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 324831001495 GAF domain; Region: GAF_2; pfam13185 324831001496 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 324831001497 Predicted permeases [General function prediction only]; Region: COG0679 324831001498 CAAX protease self-immunity; Region: Abi; pfam02517 324831001499 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 324831001500 amphipathic channel; other site 324831001501 Asn-Pro-Ala signature motifs; other site 324831001502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831001503 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324831001504 putative substrate translocation pore; other site 324831001505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831001506 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324831001507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831001508 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324831001509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324831001510 myosin-cross-reactive antigen; Provisional; Region: PRK13977 324831001511 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324831001512 Coenzyme A binding pocket [chemical binding]; other site 324831001513 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831001514 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324831001515 active site 324831001516 motif I; other site 324831001517 motif II; other site 324831001518 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 324831001519 motif II; other site 324831001520 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 324831001521 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831001522 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324831001523 active site 324831001524 motif I; other site 324831001525 motif II; other site 324831001526 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 324831001527 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324831001528 uracil transporter; Provisional; Region: PRK10720 324831001529 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324831001530 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 324831001531 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 324831001532 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 324831001533 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 324831001534 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 324831001535 active site 324831001536 phosphorylation site [posttranslational modification] 324831001537 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 324831001538 active site 324831001539 P-loop; other site 324831001540 phosphorylation site [posttranslational modification] 324831001541 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 324831001542 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 324831001543 transcriptional antiterminator BglG; Provisional; Region: PRK09772 324831001544 CAT RNA binding domain; Region: CAT_RBD; smart01061 324831001545 PRD domain; Region: PRD; pfam00874 324831001546 PRD domain; Region: PRD; pfam00874 324831001547 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 324831001548 methionine cluster; other site 324831001549 active site 324831001550 phosphorylation site [posttranslational modification] 324831001551 metal binding site [ion binding]; metal-binding site 324831001552 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 324831001553 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 324831001554 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 324831001555 active site 324831001556 P-loop; other site 324831001557 phosphorylation site [posttranslational modification] 324831001558 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 324831001559 beta-galactosidase; Region: BGL; TIGR03356 324831001560 AAA ATPase domain; Region: AAA_16; pfam13191 324831001561 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324831001562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324831001563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324831001564 dimerization interface [polypeptide binding]; other site 324831001565 hypothetical protein; Validated; Region: PRK07121 324831001566 Predicted oxidoreductase [General function prediction only]; Region: COG3573 324831001567 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 324831001568 FMN-binding domain; Region: FMN_bind; pfam04205 324831001569 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 324831001570 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 324831001571 transmembrane helices; other site 324831001572 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 324831001573 glutaminase A; Region: Gln_ase; TIGR03814 324831001574 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 324831001575 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 324831001576 active site 324831001577 drug efflux system protein MdtG; Provisional; Region: PRK09874 324831001578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831001579 putative substrate translocation pore; other site 324831001580 Transcriptional regulators [Transcription]; Region: MarR; COG1846 324831001581 MarR family; Region: MarR_2; pfam12802 324831001582 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 324831001583 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 324831001584 oligomer interface [polypeptide binding]; other site 324831001585 active site 324831001586 metal binding site [ion binding]; metal-binding site 324831001587 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 324831001588 active site 324831001589 phosphorylation site [posttranslational modification] 324831001590 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 324831001591 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 324831001592 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 324831001593 active pocket/dimerization site; other site 324831001594 active site 324831001595 phosphorylation site [posttranslational modification] 324831001596 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 324831001597 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 324831001598 Ca binding site [ion binding]; other site 324831001599 active site 324831001600 catalytic site [active] 324831001601 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324831001602 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324831001603 DNA binding site [nucleotide binding] 324831001604 domain linker motif; other site 324831001605 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 324831001606 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 324831001607 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 324831001608 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 324831001609 putative active site [active] 324831001610 putative catalytic site [active] 324831001611 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 324831001612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831001613 putative substrate translocation pore; other site 324831001614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831001615 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 324831001616 Transcriptional regulators [Transcription]; Region: MarR; COG1846 324831001617 MarR family; Region: MarR_2; pfam12802 324831001618 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324831001619 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324831001620 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324831001621 Walker A/P-loop; other site 324831001622 ATP binding site [chemical binding]; other site 324831001623 Q-loop/lid; other site 324831001624 ABC transporter signature motif; other site 324831001625 Walker B; other site 324831001626 D-loop; other site 324831001627 H-loop/switch region; other site 324831001628 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324831001629 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324831001630 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 324831001631 Walker A/P-loop; other site 324831001632 ATP binding site [chemical binding]; other site 324831001633 Q-loop/lid; other site 324831001634 ABC transporter signature motif; other site 324831001635 Walker B; other site 324831001636 D-loop; other site 324831001637 H-loop/switch region; other site 324831001638 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 324831001639 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324831001640 substrate binding pocket [chemical binding]; other site 324831001641 membrane-bound complex binding site; other site 324831001642 hinge residues; other site 324831001643 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 324831001644 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 324831001645 Walker A/P-loop; other site 324831001646 ATP binding site [chemical binding]; other site 324831001647 Q-loop/lid; other site 324831001648 ABC transporter signature motif; other site 324831001649 Walker B; other site 324831001650 D-loop; other site 324831001651 H-loop/switch region; other site 324831001652 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 324831001653 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324831001654 substrate binding pocket [chemical binding]; other site 324831001655 membrane-bound complex binding site; other site 324831001656 hinge residues; other site 324831001657 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 324831001658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831001659 dimer interface [polypeptide binding]; other site 324831001660 conserved gate region; other site 324831001661 putative PBP binding loops; other site 324831001662 ABC-ATPase subunit interface; other site 324831001663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831001664 dimer interface [polypeptide binding]; other site 324831001665 conserved gate region; other site 324831001666 putative PBP binding loops; other site 324831001667 ABC-ATPase subunit interface; other site 324831001668 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 324831001669 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 324831001670 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 324831001671 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 324831001672 Ca binding site [ion binding]; other site 324831001673 active site 324831001674 catalytic site [active] 324831001675 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324831001676 DNA-binding site [nucleotide binding]; DNA binding site 324831001677 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 324831001678 UTRA domain; Region: UTRA; pfam07702 324831001679 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 324831001680 HPr interaction site; other site 324831001681 glycerol kinase (GK) interaction site [polypeptide binding]; other site 324831001682 active site 324831001683 phosphorylation site [posttranslational modification] 324831001684 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 324831001685 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 324831001686 active site turn [active] 324831001687 phosphorylation site [posttranslational modification] 324831001688 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 324831001689 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 324831001690 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324831001691 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324831001692 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 324831001693 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 324831001694 Sugar specificity; other site 324831001695 Pyrimidine base specificity; other site 324831001696 ATP-binding site [chemical binding]; other site 324831001697 Enterocin A Immunity; Region: EntA_Immun; pfam08951 324831001698 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 324831001699 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 324831001700 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324831001701 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 324831001702 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 324831001703 Soluble P-type ATPase [General function prediction only]; Region: COG4087 324831001704 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 324831001705 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 324831001706 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 324831001707 active site 324831001708 nucleophile elbow; other site 324831001709 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 324831001710 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324831001711 substrate binding pocket [chemical binding]; other site 324831001712 membrane-bound complex binding site; other site 324831001713 hinge residues; other site 324831001714 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 324831001715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831001716 dimer interface [polypeptide binding]; other site 324831001717 conserved gate region; other site 324831001718 putative PBP binding loops; other site 324831001719 ABC-ATPase subunit interface; other site 324831001720 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 324831001721 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 324831001722 Walker A/P-loop; other site 324831001723 ATP binding site [chemical binding]; other site 324831001724 Q-loop/lid; other site 324831001725 ABC transporter signature motif; other site 324831001726 Walker B; other site 324831001727 D-loop; other site 324831001728 H-loop/switch region; other site 324831001729 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 324831001730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324831001731 Coenzyme A binding pocket [chemical binding]; other site 324831001732 PBP superfamily domain; Region: PBP_like_2; cl17296 324831001733 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 324831001734 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 324831001735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831001736 dimer interface [polypeptide binding]; other site 324831001737 conserved gate region; other site 324831001738 putative PBP binding loops; other site 324831001739 ABC-ATPase subunit interface; other site 324831001740 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 324831001741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831001742 dimer interface [polypeptide binding]; other site 324831001743 conserved gate region; other site 324831001744 putative PBP binding loops; other site 324831001745 ABC-ATPase subunit interface; other site 324831001746 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 324831001747 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 324831001748 Walker A/P-loop; other site 324831001749 ATP binding site [chemical binding]; other site 324831001750 Q-loop/lid; other site 324831001751 ABC transporter signature motif; other site 324831001752 Walker B; other site 324831001753 D-loop; other site 324831001754 H-loop/switch region; other site 324831001755 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14251 324831001756 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 324831001757 Walker A/P-loop; other site 324831001758 ATP binding site [chemical binding]; other site 324831001759 Q-loop/lid; other site 324831001760 ABC transporter signature motif; other site 324831001761 Walker B; other site 324831001762 D-loop; other site 324831001763 H-loop/switch region; other site 324831001764 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 324831001765 PhoU domain; Region: PhoU; pfam01895 324831001766 PhoU domain; Region: PhoU; pfam01895 324831001767 Predicted membrane protein [Function unknown]; Region: COG1288 324831001768 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 324831001769 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 324831001770 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 324831001771 dimerization interface [polypeptide binding]; other site 324831001772 DPS ferroxidase diiron center [ion binding]; other site 324831001773 ion pore; other site 324831001774 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 324831001775 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 324831001776 substrate binding site [chemical binding]; other site 324831001777 dimer interface [polypeptide binding]; other site 324831001778 ATP binding site [chemical binding]; other site 324831001779 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 324831001780 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324831001781 active site 324831001782 dimer interface [polypeptide binding]; other site 324831001783 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 324831001784 active site 324831001785 tetramer interface [polypeptide binding]; other site 324831001786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324831001787 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 324831001788 DNA-binding site [nucleotide binding]; DNA binding site 324831001789 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 324831001790 Enterocin A Immunity; Region: EntA_Immun; pfam08951 324831001791 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324831001792 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 324831001793 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 324831001794 putative phosphoketolase; Provisional; Region: PRK05261 324831001795 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 324831001796 TPP-binding site; other site 324831001797 XFP C-terminal domain; Region: XFP_C; pfam09363 324831001798 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 324831001799 putative FMN binding site [chemical binding]; other site 324831001800 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 324831001801 Domain of unknown function DUF21; Region: DUF21; pfam01595 324831001802 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 324831001803 Transporter associated domain; Region: CorC_HlyC; smart01091 324831001804 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324831001805 active site 324831001806 amino acid transporter; Region: 2A0306; TIGR00909 324831001807 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 324831001808 active site 324831001809 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 324831001810 DEAD-like helicases superfamily; Region: DEXDc; smart00487 324831001811 ATP binding site [chemical binding]; other site 324831001812 putative Mg++ binding site [ion binding]; other site 324831001813 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324831001814 nucleotide binding region [chemical binding]; other site 324831001815 ATP-binding site [chemical binding]; other site 324831001816 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 324831001817 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 324831001818 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 324831001819 Int/Topo IB signature motif; other site 324831001820 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 324831001821 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324831001822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324831001823 non-specific DNA binding site [nucleotide binding]; other site 324831001824 salt bridge; other site 324831001825 sequence-specific DNA binding site [nucleotide binding]; other site 324831001826 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324831001827 non-specific DNA binding site [nucleotide binding]; other site 324831001828 salt bridge; other site 324831001829 sequence-specific DNA binding site [nucleotide binding]; other site 324831001830 Domain of unknown function (DUF771); Region: DUF771; pfam05595 324831001831 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 324831001832 ERF superfamily; Region: ERF; pfam04404 324831001833 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 324831001834 AntA/AntB antirepressor; Region: AntA; cl01430 324831001835 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 324831001836 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 324831001837 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 324831001838 ParB-like nuclease domain; Region: ParB; smart00470 324831001839 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 324831001840 Terminase small subunit; Region: Terminase_2; pfam03592 324831001841 NUMOD4 motif; Region: NUMOD4; pfam07463 324831001842 HNH endonuclease; Region: HNH_3; pfam13392 324831001843 Intron encoded nuclease repeat motif; Region: IENR1; smart00497 324831001844 Phage terminase large subunit; Region: Terminase_3; cl12054 324831001845 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 324831001846 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 324831001847 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 324831001848 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 324831001849 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 324831001850 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 324831001851 Phage XkdN-like protein; Region: XkdN; pfam08890 324831001852 tape measure domain; Region: tape_meas_nterm; TIGR02675 324831001853 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 324831001854 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 324831001855 Baseplate J-like protein; Region: Baseplate_J; pfam04865 324831001856 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 324831001857 hypothetical protein; Provisional; Region: PRK09609 324831001858 Phage holin protein (Holin_LLH); Region: Holin_LLH; pfam09682 324831001859 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 324831001860 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 324831001861 active site 324831001862 Bacterial SH3 domain; Region: SH3_5; pfam08460 324831001863 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 324831001864 Int/Topo IB signature motif; other site 324831001865 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 324831001866 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324831001867 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324831001868 non-specific DNA binding site [nucleotide binding]; other site 324831001869 salt bridge; other site 324831001870 sequence-specific DNA binding site [nucleotide binding]; other site 324831001871 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324831001872 non-specific DNA binding site [nucleotide binding]; other site 324831001873 salt bridge; other site 324831001874 sequence-specific DNA binding site [nucleotide binding]; other site 324831001875 Domain of unknown function (DUF771); Region: DUF771; pfam05595 324831001876 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 324831001877 ERF superfamily; Region: ERF; pfam04404 324831001878 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 324831001879 AntA/AntB antirepressor; Region: AntA; cl01430 324831001880 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 324831001881 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 324831001882 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 324831001883 ParB-like nuclease domain; Region: ParB; smart00470 324831001884 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 324831001885 Terminase small subunit; Region: Terminase_2; pfam03592 324831001886 NUMOD4 motif; Region: NUMOD4; pfam07463 324831001887 HNH endonuclease; Region: HNH_3; pfam13392 324831001888 Intron encoded nuclease repeat motif; Region: IENR1; smart00497 324831001889 Phage terminase large subunit; Region: Terminase_3; cl12054 324831001890 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 324831001891 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 324831001892 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 324831001893 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 324831001894 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 324831001895 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 324831001896 Phage XkdN-like protein; Region: XkdN; pfam08890 324831001897 tape measure domain; Region: tape_meas_nterm; TIGR02675 324831001898 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 324831001899 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 324831001900 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 324831001901 Baseplate J-like protein; Region: Baseplate_J; pfam04865 324831001902 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 324831001903 hypothetical protein; Provisional; Region: PRK09609 324831001904 Phage holin protein (Holin_LLH); Region: Holin_LLH; pfam09682 324831001905 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 324831001906 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 324831001907 active site 324831001908 Bacterial SH3 domain; Region: SH3_5; pfam08460 324831001909 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 324831001910 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 324831001911 active site 324831001912 homodimer interface [polypeptide binding]; other site 324831001913 Predicted membrane protein [Function unknown]; Region: COG2246 324831001914 GtrA-like protein; Region: GtrA; pfam04138 324831001915 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 324831001916 methionine aminopeptidase; Provisional; Region: PRK08671 324831001917 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 324831001918 active site 324831001919 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 324831001920 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 324831001921 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 324831001922 active site 324831001923 tetramer interface; other site 324831001924 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 324831001925 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 324831001926 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 324831001927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324831001928 Walker A/P-loop; other site 324831001929 ATP binding site [chemical binding]; other site 324831001930 Q-loop/lid; other site 324831001931 ABC transporter signature motif; other site 324831001932 Walker B; other site 324831001933 D-loop; other site 324831001934 H-loop/switch region; other site 324831001935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831001936 conserved gate region; other site 324831001937 ABC-ATPase subunit interface; other site 324831001938 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 324831001939 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 324831001940 OsmC-like protein; Region: OsmC; pfam02566 324831001941 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 324831001942 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 324831001943 synthetase active site [active] 324831001944 NTP binding site [chemical binding]; other site 324831001945 metal binding site [ion binding]; metal-binding site 324831001946 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 324831001947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324831001948 active site 324831001949 phosphorylation site [posttranslational modification] 324831001950 intermolecular recognition site; other site 324831001951 dimerization interface [polypeptide binding]; other site 324831001952 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324831001953 DNA binding site [nucleotide binding] 324831001954 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324831001955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324831001956 dimer interface [polypeptide binding]; other site 324831001957 phosphorylation site [posttranslational modification] 324831001958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324831001959 ATP binding site [chemical binding]; other site 324831001960 Mg2+ binding site [ion binding]; other site 324831001961 G-X-G motif; other site 324831001962 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 324831001963 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 324831001964 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 324831001965 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 324831001966 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 324831001967 Zn binding site [ion binding]; other site 324831001968 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 324831001969 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324831001970 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831001971 active site 324831001972 motif I; other site 324831001973 motif II; other site 324831001974 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 324831001975 CAAX protease self-immunity; Region: Abi; pfam02517 324831001976 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 324831001977 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 324831001978 glutaminase active site [active] 324831001979 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 324831001980 dimer interface [polypeptide binding]; other site 324831001981 active site 324831001982 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 324831001983 dimer interface [polypeptide binding]; other site 324831001984 active site 324831001985 Fic/DOC family; Region: Fic; cl00960 324831001986 Acyltransferase family; Region: Acyl_transf_3; pfam01757 324831001987 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 324831001988 putative FMN binding site [chemical binding]; other site 324831001989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831001990 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324831001991 putative substrate translocation pore; other site 324831001992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831001993 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 324831001994 DNA binding residues [nucleotide binding] 324831001995 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324831001996 putative dimer interface [polypeptide binding]; other site 324831001997 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 324831001998 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 324831001999 peptide binding site [polypeptide binding]; other site 324831002000 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 324831002001 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 324831002002 trimer interface [polypeptide binding]; other site 324831002003 active site 324831002004 G bulge; other site 324831002005 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324831002006 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 324831002007 nucleotide binding site [chemical binding]; other site 324831002008 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324831002009 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324831002010 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324831002011 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 324831002012 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 324831002013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831002014 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324831002015 putative substrate translocation pore; other site 324831002016 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 324831002017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324831002018 Coenzyme A binding pocket [chemical binding]; other site 324831002019 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 324831002020 dimer interface [polypeptide binding]; other site 324831002021 pyridoxal binding site [chemical binding]; other site 324831002022 ATP binding site [chemical binding]; other site 324831002023 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 324831002024 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 324831002025 active site 1 [active] 324831002026 dimer interface [polypeptide binding]; other site 324831002027 hexamer interface [polypeptide binding]; other site 324831002028 active site 2 [active] 324831002029 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 324831002030 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 324831002031 Uncharacterized conserved protein [Function unknown]; Region: COG1284 324831002032 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324831002033 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324831002034 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 324831002035 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 324831002036 ArsC family; Region: ArsC; pfam03960 324831002037 putative ArsC-like catalytic residues; other site 324831002038 putative TRX-like catalytic residues [active] 324831002039 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 324831002040 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 324831002041 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 324831002042 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 324831002043 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 324831002044 active site 324831002045 elongation factor P; Validated; Region: PRK00529 324831002046 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 324831002047 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 324831002048 RNA binding site [nucleotide binding]; other site 324831002049 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 324831002050 RNA binding site [nucleotide binding]; other site 324831002051 Asp23 family; Region: Asp23; pfam03780 324831002052 transcription antitermination factor NusB; Region: nusB; TIGR01951 324831002053 putative RNA binding site [nucleotide binding]; other site 324831002054 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 324831002055 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 324831002056 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 324831002057 homodimer interface [polypeptide binding]; other site 324831002058 NADP binding site [chemical binding]; other site 324831002059 substrate binding site [chemical binding]; other site 324831002060 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 324831002061 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 324831002062 generic binding surface II; other site 324831002063 generic binding surface I; other site 324831002064 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 324831002065 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 324831002066 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 324831002067 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 324831002068 substrate binding pocket [chemical binding]; other site 324831002069 chain length determination region; other site 324831002070 substrate-Mg2+ binding site; other site 324831002071 catalytic residues [active] 324831002072 aspartate-rich region 1; other site 324831002073 active site lid residues [active] 324831002074 aspartate-rich region 2; other site 324831002075 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 324831002076 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324831002077 RNA binding surface [nucleotide binding]; other site 324831002078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324831002079 S-adenosylmethionine binding site [chemical binding]; other site 324831002080 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 324831002081 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 324831002082 Walker A/P-loop; other site 324831002083 ATP binding site [chemical binding]; other site 324831002084 Q-loop/lid; other site 324831002085 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 324831002086 ABC transporter signature motif; other site 324831002087 Walker B; other site 324831002088 D-loop; other site 324831002089 H-loop/switch region; other site 324831002090 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 324831002091 catalytic site [active] 324831002092 G-X2-G-X-G-K; other site 324831002093 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 324831002094 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 324831002095 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 324831002096 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324831002097 ATP binding site [chemical binding]; other site 324831002098 putative Mg++ binding site [ion binding]; other site 324831002099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324831002100 nucleotide binding region [chemical binding]; other site 324831002101 ATP-binding site [chemical binding]; other site 324831002102 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 324831002103 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 324831002104 putative active site [active] 324831002105 substrate binding site [chemical binding]; other site 324831002106 putative cosubstrate binding site; other site 324831002107 catalytic site [active] 324831002108 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 324831002109 substrate binding site [chemical binding]; other site 324831002110 16S rRNA methyltransferase B; Provisional; Region: PRK14902 324831002111 NusB family; Region: NusB; pfam01029 324831002112 putative RNA binding site [nucleotide binding]; other site 324831002113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324831002114 S-adenosylmethionine binding site [chemical binding]; other site 324831002115 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 324831002116 Protein phosphatase 2C; Region: PP2C; pfam00481 324831002117 active site 324831002118 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324831002119 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 324831002120 active site 324831002121 ATP binding site [chemical binding]; other site 324831002122 substrate binding site [chemical binding]; other site 324831002123 activation loop (A-loop); other site 324831002124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 324831002125 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 324831002126 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 324831002127 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 324831002128 GTPase RsgA; Reviewed; Region: PRK00098 324831002129 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 324831002130 RNA binding site [nucleotide binding]; other site 324831002131 homodimer interface [polypeptide binding]; other site 324831002132 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 324831002133 GTPase/Zn-binding domain interface [polypeptide binding]; other site 324831002134 GTP/Mg2+ binding site [chemical binding]; other site 324831002135 G4 box; other site 324831002136 G1 box; other site 324831002137 Switch I region; other site 324831002138 G2 box; other site 324831002139 G3 box; other site 324831002140 Switch II region; other site 324831002141 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 324831002142 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 324831002143 substrate binding site [chemical binding]; other site 324831002144 hexamer interface [polypeptide binding]; other site 324831002145 metal binding site [ion binding]; metal-binding site 324831002146 Thiamine pyrophosphokinase; Region: TPK; cd07995 324831002147 active site 324831002148 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 324831002149 dimerization interface [polypeptide binding]; other site 324831002150 thiamine binding site [chemical binding]; other site 324831002151 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 324831002152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 324831002153 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 324831002154 DAK2 domain; Region: Dak2; pfam02734 324831002155 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 324831002156 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 324831002157 ssDNA binding site; other site 324831002158 generic binding surface II; other site 324831002159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324831002160 ATP binding site [chemical binding]; other site 324831002161 putative Mg++ binding site [ion binding]; other site 324831002162 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324831002163 nucleotide binding region [chemical binding]; other site 324831002164 ATP-binding site [chemical binding]; other site 324831002165 putative phosphate acyltransferase; Provisional; Region: PRK05331 324831002166 acyl carrier protein; Provisional; Region: acpP; PRK00982 324831002167 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 324831002168 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324831002169 Walker A/P-loop; other site 324831002170 ATP binding site [chemical binding]; other site 324831002171 Q-loop/lid; other site 324831002172 ABC transporter signature motif; other site 324831002173 Walker B; other site 324831002174 D-loop; other site 324831002175 H-loop/switch region; other site 324831002176 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324831002177 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324831002178 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 324831002179 Walker A/P-loop; other site 324831002180 ATP binding site [chemical binding]; other site 324831002181 Q-loop/lid; other site 324831002182 ABC transporter signature motif; other site 324831002183 Walker B; other site 324831002184 D-loop; other site 324831002185 H-loop/switch region; other site 324831002186 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 324831002187 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 324831002188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831002189 dimer interface [polypeptide binding]; other site 324831002190 conserved gate region; other site 324831002191 putative PBP binding loops; other site 324831002192 ABC-ATPase subunit interface; other site 324831002193 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 324831002194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831002195 dimer interface [polypeptide binding]; other site 324831002196 conserved gate region; other site 324831002197 putative PBP binding loops; other site 324831002198 ABC-ATPase subunit interface; other site 324831002199 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 324831002200 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 324831002201 peptide binding site [polypeptide binding]; other site 324831002202 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 324831002203 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 324831002204 peptide binding site [polypeptide binding]; other site 324831002205 ribonuclease III; Reviewed; Region: rnc; PRK00102 324831002206 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 324831002207 dimerization interface [polypeptide binding]; other site 324831002208 active site 324831002209 metal binding site [ion binding]; metal-binding site 324831002210 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 324831002211 dsRNA binding site [nucleotide binding]; other site 324831002212 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 324831002213 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 324831002214 Walker A/P-loop; other site 324831002215 ATP binding site [chemical binding]; other site 324831002216 Q-loop/lid; other site 324831002217 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 324831002218 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 324831002219 ABC transporter signature motif; other site 324831002220 Walker B; other site 324831002221 D-loop; other site 324831002222 H-loop/switch region; other site 324831002223 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 324831002224 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 324831002225 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 324831002226 P loop; other site 324831002227 GTP binding site [chemical binding]; other site 324831002228 Peptidase family C69; Region: Peptidase_C69; pfam03577 324831002229 putative DNA-binding protein; Validated; Region: PRK00118 324831002230 signal recognition particle protein; Provisional; Region: PRK10867 324831002231 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 324831002232 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 324831002233 P loop; other site 324831002234 GTP binding site [chemical binding]; other site 324831002235 Signal peptide binding domain; Region: SRP_SPB; pfam02978 324831002236 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 324831002237 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 324831002238 RimM N-terminal domain; Region: RimM; pfam01782 324831002239 PRC-barrel domain; Region: PRC; pfam05239 324831002240 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 324831002241 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 324831002242 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 324831002243 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 324831002244 Catalytic site [active] 324831002245 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 324831002246 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 324831002247 active site 324831002248 Ap4A binding cleft/pocket [chemical binding]; other site 324831002249 P4 phosphate binding site; other site 324831002250 nudix motif; other site 324831002251 putative P2/P3 phosphate binding site [ion binding]; other site 324831002252 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 324831002253 active site 324831002254 Fe-S cluster binding site [ion binding]; other site 324831002255 LexA repressor; Validated; Region: PRK00215 324831002256 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324831002257 putative DNA binding site [nucleotide binding]; other site 324831002258 putative Zn2+ binding site [ion binding]; other site 324831002259 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 324831002260 Catalytic site [active] 324831002261 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 324831002262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 324831002263 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324831002264 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 324831002265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324831002266 Walker A/P-loop; other site 324831002267 ATP binding site [chemical binding]; other site 324831002268 Q-loop/lid; other site 324831002269 ABC transporter signature motif; other site 324831002270 Walker B; other site 324831002271 D-loop; other site 324831002272 H-loop/switch region; other site 324831002273 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324831002274 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324831002275 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 324831002276 Walker A/P-loop; other site 324831002277 ATP binding site [chemical binding]; other site 324831002278 Q-loop/lid; other site 324831002279 ABC transporter signature motif; other site 324831002280 Walker B; other site 324831002281 D-loop; other site 324831002282 H-loop/switch region; other site 324831002283 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 324831002284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324831002285 S-adenosylmethionine binding site [chemical binding]; other site 324831002286 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 324831002287 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 324831002288 putative acyl-acceptor binding pocket; other site 324831002289 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 324831002290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324831002291 S-adenosylmethionine binding site [chemical binding]; other site 324831002292 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 324831002293 GIY-YIG motif/motif A; other site 324831002294 putative active site [active] 324831002295 putative metal binding site [ion binding]; other site 324831002296 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 324831002297 rRNA interaction site [nucleotide binding]; other site 324831002298 S8 interaction site; other site 324831002299 putative laminin-1 binding site; other site 324831002300 elongation factor Ts; Provisional; Region: tsf; PRK09377 324831002301 UBA/TS-N domain; Region: UBA; pfam00627 324831002302 Elongation factor TS; Region: EF_TS; pfam00889 324831002303 Elongation factor TS; Region: EF_TS; pfam00889 324831002304 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 324831002305 putative nucleotide binding site [chemical binding]; other site 324831002306 uridine monophosphate binding site [chemical binding]; other site 324831002307 homohexameric interface [polypeptide binding]; other site 324831002308 ribosome recycling factor; Reviewed; Region: frr; PRK00083 324831002309 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 324831002310 hinge region; other site 324831002311 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 324831002312 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 324831002313 catalytic residue [active] 324831002314 putative FPP diphosphate binding site; other site 324831002315 putative FPP binding hydrophobic cleft; other site 324831002316 dimer interface [polypeptide binding]; other site 324831002317 putative IPP diphosphate binding site; other site 324831002318 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 324831002319 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 324831002320 RIP metalloprotease RseP; Region: TIGR00054 324831002321 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 324831002322 active site 324831002323 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 324831002324 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 324831002325 protein binding site [polypeptide binding]; other site 324831002326 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 324831002327 putative substrate binding region [chemical binding]; other site 324831002328 prolyl-tRNA synthetase; Provisional; Region: PRK09194 324831002329 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 324831002330 dimer interface [polypeptide binding]; other site 324831002331 motif 1; other site 324831002332 active site 324831002333 motif 2; other site 324831002334 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 324831002335 putative deacylase active site [active] 324831002336 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 324831002337 active site 324831002338 motif 3; other site 324831002339 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 324831002340 anticodon binding site; other site 324831002341 DNA polymerase III PolC; Validated; Region: polC; PRK00448 324831002342 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 324831002343 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 324831002344 generic binding surface II; other site 324831002345 generic binding surface I; other site 324831002346 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 324831002347 active site 324831002348 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 324831002349 active site 324831002350 catalytic site [active] 324831002351 substrate binding site [chemical binding]; other site 324831002352 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 324831002353 ribosome maturation protein RimP; Reviewed; Region: PRK00092 324831002354 Sm and related proteins; Region: Sm_like; cl00259 324831002355 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 324831002356 putative oligomer interface [polypeptide binding]; other site 324831002357 putative RNA binding site [nucleotide binding]; other site 324831002358 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 324831002359 NusA N-terminal domain; Region: NusA_N; pfam08529 324831002360 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 324831002361 RNA binding site [nucleotide binding]; other site 324831002362 homodimer interface [polypeptide binding]; other site 324831002363 NusA-like KH domain; Region: KH_5; pfam13184 324831002364 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 324831002365 G-X-X-G motif; other site 324831002366 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 324831002367 putative RNA binding cleft [nucleotide binding]; other site 324831002368 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 324831002369 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 324831002370 translation initiation factor IF-2; Validated; Region: infB; PRK05306 324831002371 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 324831002372 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 324831002373 G1 box; other site 324831002374 putative GEF interaction site [polypeptide binding]; other site 324831002375 GTP/Mg2+ binding site [chemical binding]; other site 324831002376 Switch I region; other site 324831002377 G2 box; other site 324831002378 G3 box; other site 324831002379 Switch II region; other site 324831002380 G4 box; other site 324831002381 G5 box; other site 324831002382 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 324831002383 Translation-initiation factor 2; Region: IF-2; pfam11987 324831002384 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 324831002385 ribosome-binding factor A; Provisional; Region: PRK13818 324831002386 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 324831002387 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 324831002388 RNA binding site [nucleotide binding]; other site 324831002389 active site 324831002390 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 324831002391 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 324831002392 active site 324831002393 Riboflavin kinase; Region: Flavokinase; pfam01687 324831002394 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324831002395 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324831002396 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324831002397 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 324831002398 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 324831002399 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 324831002400 GrpE; Region: GrpE; pfam01025 324831002401 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 324831002402 dimer interface [polypeptide binding]; other site 324831002403 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 324831002404 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 324831002405 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 324831002406 nucleotide binding site [chemical binding]; other site 324831002407 NEF interaction site [polypeptide binding]; other site 324831002408 SBD interface [polypeptide binding]; other site 324831002409 chaperone protein DnaJ; Provisional; Region: PRK14276 324831002410 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 324831002411 HSP70 interaction site [polypeptide binding]; other site 324831002412 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 324831002413 substrate binding site [polypeptide binding]; other site 324831002414 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 324831002415 Zn binding sites [ion binding]; other site 324831002416 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 324831002417 dimer interface [polypeptide binding]; other site 324831002418 GTP-binding protein LepA; Provisional; Region: PRK05433 324831002419 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 324831002420 G1 box; other site 324831002421 putative GEF interaction site [polypeptide binding]; other site 324831002422 GTP/Mg2+ binding site [chemical binding]; other site 324831002423 Switch I region; other site 324831002424 G2 box; other site 324831002425 G3 box; other site 324831002426 Switch II region; other site 324831002427 G4 box; other site 324831002428 G5 box; other site 324831002429 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 324831002430 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 324831002431 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 324831002432 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 324831002433 active site 324831002434 catalytic site [active] 324831002435 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 324831002436 DHH family; Region: DHH; pfam01368 324831002437 DHHA1 domain; Region: DHHA1; pfam02272 324831002438 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 324831002439 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324831002440 active site 324831002441 inner membrane transporter YjeM; Provisional; Region: PRK15238 324831002442 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 324831002443 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 324831002444 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 324831002445 putative active site [active] 324831002446 catalytic site [active] 324831002447 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 324831002448 putative active site [active] 324831002449 catalytic site [active] 324831002450 thymidylate synthase; Region: thym_sym; TIGR03284 324831002451 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 324831002452 dimerization interface [polypeptide binding]; other site 324831002453 active site 324831002454 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 324831002455 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 324831002456 folate binding site [chemical binding]; other site 324831002457 NADP+ binding site [chemical binding]; other site 324831002458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831002459 putative substrate translocation pore; other site 324831002460 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324831002461 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 324831002462 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324831002463 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 324831002464 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831002465 motif II; other site 324831002466 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324831002467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324831002468 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324831002469 dimerization interface [polypeptide binding]; other site 324831002470 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 324831002471 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 324831002472 active site 324831002473 enolase; Provisional; Region: eno; PRK00077 324831002474 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 324831002475 dimer interface [polypeptide binding]; other site 324831002476 metal binding site [ion binding]; metal-binding site 324831002477 substrate binding pocket [chemical binding]; other site 324831002478 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 324831002479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324831002480 Walker A/P-loop; other site 324831002481 ATP binding site [chemical binding]; other site 324831002482 Q-loop/lid; other site 324831002483 ABC transporter signature motif; other site 324831002484 Walker B; other site 324831002485 D-loop; other site 324831002486 H-loop/switch region; other site 324831002487 ABC transporter; Region: ABC_tran_2; pfam12848 324831002488 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324831002489 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324831002490 non-specific DNA binding site [nucleotide binding]; other site 324831002491 salt bridge; other site 324831002492 sequence-specific DNA binding site [nucleotide binding]; other site 324831002493 Cell division protein FtsL; Region: FtsL; cl11433 324831002494 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 324831002495 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 324831002496 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 324831002497 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 324831002498 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 324831002499 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 324831002500 Walker A/P-loop; other site 324831002501 ATP binding site [chemical binding]; other site 324831002502 Q-loop/lid; other site 324831002503 ABC transporter signature motif; other site 324831002504 Walker B; other site 324831002505 D-loop; other site 324831002506 H-loop/switch region; other site 324831002507 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 324831002508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831002509 dimer interface [polypeptide binding]; other site 324831002510 conserved gate region; other site 324831002511 ABC-ATPase subunit interface; other site 324831002512 fumarate hydratase; Reviewed; Region: fumC; PRK00485 324831002513 Class II fumarases; Region: Fumarase_classII; cd01362 324831002514 active site 324831002515 tetramer interface [polypeptide binding]; other site 324831002516 L-aspartate oxidase; Provisional; Region: PRK06175 324831002517 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 324831002518 Predicted oxidoreductase [General function prediction only]; Region: COG3573 324831002519 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 324831002520 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 324831002521 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324831002522 NAD binding site [chemical binding]; other site 324831002523 dimer interface [polypeptide binding]; other site 324831002524 substrate binding site [chemical binding]; other site 324831002525 Uncharacterized conserved protein [Function unknown]; Region: COG2966 324831002526 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 324831002527 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 324831002528 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 324831002529 active site 324831002530 homodimer interface [polypeptide binding]; other site 324831002531 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 324831002532 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324831002533 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831002534 motif II; other site 324831002535 Predicted integral membrane protein [Function unknown]; Region: COG5617 324831002536 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 324831002537 putative deacylase active site [active] 324831002538 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 324831002539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324831002540 S-adenosylmethionine binding site [chemical binding]; other site 324831002541 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 324831002542 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324831002543 Zn2+ binding site [ion binding]; other site 324831002544 Mg2+ binding site [ion binding]; other site 324831002545 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 324831002546 synthetase active site [active] 324831002547 NTP binding site [chemical binding]; other site 324831002548 metal binding site [ion binding]; metal-binding site 324831002549 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 324831002550 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 324831002551 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 324831002552 putative active site [active] 324831002553 dimerization interface [polypeptide binding]; other site 324831002554 putative tRNAtyr binding site [nucleotide binding]; other site 324831002555 histidyl-tRNA synthetase; Region: hisS; TIGR00442 324831002556 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 324831002557 dimer interface [polypeptide binding]; other site 324831002558 motif 1; other site 324831002559 active site 324831002560 motif 2; other site 324831002561 motif 3; other site 324831002562 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 324831002563 anticodon binding site; other site 324831002564 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 324831002565 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 324831002566 dimer interface [polypeptide binding]; other site 324831002567 anticodon binding site; other site 324831002568 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 324831002569 homodimer interface [polypeptide binding]; other site 324831002570 motif 1; other site 324831002571 active site 324831002572 motif 2; other site 324831002573 GAD domain; Region: GAD; pfam02938 324831002574 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 324831002575 active site 324831002576 motif 3; other site 324831002577 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 324831002578 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 324831002579 putative active site [active] 324831002580 nucleotide binding site [chemical binding]; other site 324831002581 nudix motif; other site 324831002582 putative metal binding site [ion binding]; other site 324831002583 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 324831002584 Rib/alpha-like repeat; Region: Rib; pfam08428 324831002585 Amino acid permease; Region: AA_permease_2; pfam13520 324831002586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324831002587 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324831002588 NAD(P) binding site [chemical binding]; other site 324831002589 active site 324831002590 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 324831002591 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 324831002592 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 324831002593 active site 324831002594 dimerization interface [polypeptide binding]; other site 324831002595 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 324831002596 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 324831002597 GIY-YIG motif/motif A; other site 324831002598 active site 324831002599 catalytic site [active] 324831002600 putative DNA binding site [nucleotide binding]; other site 324831002601 metal binding site [ion binding]; metal-binding site 324831002602 UvrB/uvrC motif; Region: UVR; pfam02151 324831002603 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 324831002604 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 324831002605 DNA binding site [nucleotide binding] 324831002606 GTPase CgtA; Reviewed; Region: obgE; PRK12297 324831002607 GTP1/OBG; Region: GTP1_OBG; pfam01018 324831002608 Obg GTPase; Region: Obg; cd01898 324831002609 G1 box; other site 324831002610 GTP/Mg2+ binding site [chemical binding]; other site 324831002611 Switch I region; other site 324831002612 G2 box; other site 324831002613 G3 box; other site 324831002614 Switch II region; other site 324831002615 G4 box; other site 324831002616 G5 box; other site 324831002617 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 324831002618 Acyltransferase family; Region: Acyl_transf_3; pfam01757 324831002619 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 324831002620 catalytic triad [active] 324831002621 catalytic triad [active] 324831002622 oxyanion hole [active] 324831002623 ribonuclease Z; Region: RNase_Z; TIGR02651 324831002624 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 324831002625 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324831002626 NAD(P) binding site [chemical binding]; other site 324831002627 active site 324831002628 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 324831002629 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 324831002630 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 324831002631 active site 324831002632 metal binding site [ion binding]; metal-binding site 324831002633 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 324831002634 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 324831002635 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 324831002636 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 324831002637 active site 324831002638 PHP Thumb interface [polypeptide binding]; other site 324831002639 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 324831002640 generic binding surface II; other site 324831002641 generic binding surface I; other site 324831002642 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 324831002643 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 324831002644 active site 324831002645 ADP/pyrophosphate binding site [chemical binding]; other site 324831002646 dimerization interface [polypeptide binding]; other site 324831002647 allosteric effector site; other site 324831002648 fructose-1,6-bisphosphate binding site; other site 324831002649 pyruvate kinase; Provisional; Region: PRK06354 324831002650 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 324831002651 domain interfaces; other site 324831002652 active site 324831002653 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 324831002654 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 324831002655 S1 domain; Region: S1_2; pfam13509 324831002656 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 324831002657 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 324831002658 active site 324831002659 Int/Topo IB signature motif; other site 324831002660 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 324831002661 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 324831002662 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 324831002663 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324831002664 RNA binding surface [nucleotide binding]; other site 324831002665 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 324831002666 active site 324831002667 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324831002668 Predicted membrane protein [Function unknown]; Region: COG3601 324831002669 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 324831002670 cytidylate kinase; Provisional; Region: cmk; PRK00023 324831002671 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 324831002672 CMP-binding site; other site 324831002673 The sites determining sugar specificity; other site 324831002674 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 324831002675 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 324831002676 RNA binding site [nucleotide binding]; other site 324831002677 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 324831002678 RNA binding site [nucleotide binding]; other site 324831002679 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 324831002680 RNA binding site [nucleotide binding]; other site 324831002681 GTP-binding protein Der; Reviewed; Region: PRK00093 324831002682 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 324831002683 G1 box; other site 324831002684 GTP/Mg2+ binding site [chemical binding]; other site 324831002685 Switch I region; other site 324831002686 G2 box; other site 324831002687 Switch II region; other site 324831002688 G3 box; other site 324831002689 G4 box; other site 324831002690 G5 box; other site 324831002691 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 324831002692 G1 box; other site 324831002693 GTP/Mg2+ binding site [chemical binding]; other site 324831002694 Switch I region; other site 324831002695 G2 box; other site 324831002696 G3 box; other site 324831002697 Switch II region; other site 324831002698 G4 box; other site 324831002699 G5 box; other site 324831002700 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 324831002701 IHF dimer interface [polypeptide binding]; other site 324831002702 IHF - DNA interface [nucleotide binding]; other site 324831002703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324831002704 binding surface 324831002705 TPR motif; other site 324831002706 TPR repeat; Region: TPR_11; pfam13414 324831002707 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324831002708 binding surface 324831002709 TPR motif; other site 324831002710 DEAD-like helicases superfamily; Region: DEXDc; smart00487 324831002711 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324831002712 ATP binding site [chemical binding]; other site 324831002713 putative Mg++ binding site [ion binding]; other site 324831002714 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324831002715 nucleotide binding region [chemical binding]; other site 324831002716 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 324831002717 ATP-binding site [chemical binding]; other site 324831002718 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 324831002719 HsdM N-terminal domain; Region: HsdM_N; pfam12161 324831002720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 324831002721 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 324831002722 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 324831002723 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 324831002724 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 324831002725 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 324831002726 active site 324831002727 DNA binding site [nucleotide binding] 324831002728 Int/Topo IB signature motif; other site 324831002729 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 324831002730 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 324831002731 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 324831002732 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 324831002733 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324831002734 ATP binding site [chemical binding]; other site 324831002735 putative Mg++ binding site [ion binding]; other site 324831002736 Uncharacterized conserved protein [Function unknown]; Region: COG1479 324831002737 Protein of unknown function DUF262; Region: DUF262; pfam03235 324831002738 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 324831002739 hypothetical protein; Validated; Region: PRK07121 324831002740 Predicted oxidoreductase [General function prediction only]; Region: COG3573 324831002741 FMN-binding domain; Region: FMN_bind; pfam04205 324831002742 Uncharacterized conserved protein [Function unknown]; Region: COG1284 324831002743 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324831002744 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324831002745 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 324831002746 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 324831002747 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 324831002748 active site 324831002749 NTP binding site [chemical binding]; other site 324831002750 metal binding triad [ion binding]; metal-binding site 324831002751 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 324831002752 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 324831002753 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 324831002754 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 324831002755 EDD domain protein, DegV family; Region: DegV; TIGR00762 324831002756 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 324831002757 hypothetical protein; Provisional; Region: PRK13672 324831002758 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 324831002759 C-terminal peptidase (prc); Region: prc; TIGR00225 324831002760 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 324831002761 protein binding site [polypeptide binding]; other site 324831002762 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 324831002763 Catalytic dyad [active] 324831002764 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 324831002765 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 324831002766 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 324831002767 GTP/Mg2+ binding site [chemical binding]; other site 324831002768 G4 box; other site 324831002769 G5 box; other site 324831002770 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 324831002771 G1 box; other site 324831002772 Switch I region; other site 324831002773 G2 box; other site 324831002774 G3 box; other site 324831002775 Switch II region; other site 324831002776 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 324831002777 RNA/DNA hybrid binding site [nucleotide binding]; other site 324831002778 active site 324831002779 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 324831002780 DNA protecting protein DprA; Region: dprA; TIGR00732 324831002781 DNA topoisomerase I; Validated; Region: PRK05582 324831002782 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 324831002783 active site 324831002784 interdomain interaction site; other site 324831002785 putative metal-binding site [ion binding]; other site 324831002786 nucleotide binding site [chemical binding]; other site 324831002787 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 324831002788 domain I; other site 324831002789 DNA binding groove [nucleotide binding] 324831002790 phosphate binding site [ion binding]; other site 324831002791 domain II; other site 324831002792 domain III; other site 324831002793 nucleotide binding site [chemical binding]; other site 324831002794 catalytic site [active] 324831002795 domain IV; other site 324831002796 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 324831002797 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 324831002798 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 324831002799 Glucose inhibited division protein A; Region: GIDA; pfam01134 324831002800 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 324831002801 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 324831002802 active site 324831002803 Int/Topo IB signature motif; other site 324831002804 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 324831002805 active site 324831002806 HslU subunit interaction site [polypeptide binding]; other site 324831002807 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 324831002808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324831002809 Walker A motif; other site 324831002810 ATP binding site [chemical binding]; other site 324831002811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324831002812 Walker B motif; other site 324831002813 arginine finger; other site 324831002814 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 324831002815 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 324831002816 active site 324831002817 catalytic residues [active] 324831002818 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324831002819 dimerization interface [polypeptide binding]; other site 324831002820 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 324831002821 Predicted membrane protein [Function unknown]; Region: COG2855 324831002822 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 324831002823 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324831002824 non-specific DNA binding site [nucleotide binding]; other site 324831002825 salt bridge; other site 324831002826 sequence-specific DNA binding site [nucleotide binding]; other site 324831002827 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 324831002828 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 324831002829 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 324831002830 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 324831002831 Walker A/P-loop; other site 324831002832 ATP binding site [chemical binding]; other site 324831002833 Q-loop/lid; other site 324831002834 ABC transporter signature motif; other site 324831002835 Walker B; other site 324831002836 D-loop; other site 324831002837 H-loop/switch region; other site 324831002838 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 324831002839 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324831002840 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324831002841 Coenzyme A binding pocket [chemical binding]; other site 324831002842 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 324831002843 LytTr DNA-binding domain; Region: LytTR; smart00850 324831002844 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 324831002845 MucBP domain; Region: MucBP; pfam06458 324831002846 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 324831002847 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 324831002848 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 324831002849 MucBP domain; Region: MucBP; pfam06458 324831002850 MucBP domain; Region: MucBP; pfam06458 324831002851 MucBP domain; Region: MucBP; pfam06458 324831002852 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 324831002853 Peptidase M60-like family; Region: M60-like; pfam13402 324831002854 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 324831002855 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831002856 motif II; other site 324831002857 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 324831002858 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 324831002859 nudix motif; other site 324831002860 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 324831002861 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324831002862 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324831002863 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 324831002864 Predicted transcriptional regulators [Transcription]; Region: COG1733 324831002865 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 324831002866 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 324831002867 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 324831002868 active site pocket [active] 324831002869 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324831002870 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 324831002871 Walker A/P-loop; other site 324831002872 ATP binding site [chemical binding]; other site 324831002873 Q-loop/lid; other site 324831002874 ABC transporter signature motif; other site 324831002875 Walker B; other site 324831002876 D-loop; other site 324831002877 H-loop/switch region; other site 324831002878 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 324831002879 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324831002880 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 324831002881 Walker A/P-loop; other site 324831002882 ATP binding site [chemical binding]; other site 324831002883 Q-loop/lid; other site 324831002884 ABC transporter signature motif; other site 324831002885 Walker B; other site 324831002886 D-loop; other site 324831002887 H-loop/switch region; other site 324831002888 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 324831002889 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 324831002890 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 324831002891 active site 324831002892 magnesium-transporting ATPase; Provisional; Region: PRK15122 324831002893 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 324831002894 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324831002895 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 324831002896 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831002897 motif II; other site 324831002898 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 324831002899 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324831002900 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324831002901 active site 324831002902 catalytic tetrad [active] 324831002903 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324831002904 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324831002905 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 324831002906 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 324831002907 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 324831002908 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324831002909 NAD binding site [chemical binding]; other site 324831002910 substrate binding site [chemical binding]; other site 324831002911 putative active site [active] 324831002912 H+ Antiporter protein; Region: 2A0121; TIGR00900 324831002913 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 324831002914 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 324831002915 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 324831002916 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324831002917 Predicted transcriptional regulator [Transcription]; Region: COG2378 324831002918 HTH domain; Region: HTH_11; pfam08279 324831002919 WYL domain; Region: WYL; pfam13280 324831002920 LytTr DNA-binding domain; Region: LytTR; smart00850 324831002921 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 324831002922 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 324831002923 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324831002924 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 324831002925 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 324831002926 metal-binding site [ion binding] 324831002927 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 324831002928 dinuclear metal binding motif [ion binding]; other site 324831002929 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324831002930 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324831002931 ligand binding site [chemical binding]; other site 324831002932 flexible hinge region; other site 324831002933 putative switch regulator; other site 324831002934 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 324831002935 non-specific DNA interactions [nucleotide binding]; other site 324831002936 DNA binding site [nucleotide binding] 324831002937 sequence specific DNA binding site [nucleotide binding]; other site 324831002938 putative cAMP binding site [chemical binding]; other site 324831002939 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 324831002940 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324831002941 Coenzyme A binding pocket [chemical binding]; other site 324831002942 Transcriptional regulators [Transcription]; Region: MarR; COG1846 324831002943 MarR family; Region: MarR_2; pfam12802 324831002944 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 324831002945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 324831002946 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 324831002947 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324831002948 Coenzyme A binding pocket [chemical binding]; other site 324831002949 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 324831002950 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 324831002951 recombination factor protein RarA; Reviewed; Region: PRK13342 324831002952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324831002953 Walker A motif; other site 324831002954 ATP binding site [chemical binding]; other site 324831002955 Walker B motif; other site 324831002956 arginine finger; other site 324831002957 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 324831002958 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 324831002959 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 324831002960 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324831002961 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324831002962 active site 324831002963 catalytic tetrad [active] 324831002964 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 324831002965 endonuclease III; Region: ENDO3c; smart00478 324831002966 minor groove reading motif; other site 324831002967 helix-hairpin-helix signature motif; other site 324831002968 substrate binding pocket [chemical binding]; other site 324831002969 active site 324831002970 maltose O-acetyltransferase; Provisional; Region: PRK10092 324831002971 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 324831002972 active site 324831002973 substrate binding site [chemical binding]; other site 324831002974 trimer interface [polypeptide binding]; other site 324831002975 CoA binding site [chemical binding]; other site 324831002976 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 324831002977 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 324831002978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324831002979 Mg2+ binding site [ion binding]; other site 324831002980 G-X-G motif; other site 324831002981 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 324831002982 anchoring element; other site 324831002983 dimer interface [polypeptide binding]; other site 324831002984 ATP binding site [chemical binding]; other site 324831002985 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 324831002986 active site 324831002987 putative metal-binding site [ion binding]; other site 324831002988 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 324831002989 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 324831002990 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 324831002991 CAP-like domain; other site 324831002992 active site 324831002993 primary dimer interface [polypeptide binding]; other site 324831002994 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324831002995 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324831002996 putative DNA binding site [nucleotide binding]; other site 324831002997 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324831002998 putative Zn2+ binding site [ion binding]; other site 324831002999 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324831003000 dimerization interface [polypeptide binding]; other site 324831003001 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 324831003002 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 324831003003 DHHA2 domain; Region: DHHA2; pfam02833 324831003004 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 324831003005 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324831003006 ATP binding site [chemical binding]; other site 324831003007 putative Mg++ binding site [ion binding]; other site 324831003008 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324831003009 nucleotide binding region [chemical binding]; other site 324831003010 ATP-binding site [chemical binding]; other site 324831003011 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 324831003012 HRDC domain; Region: HRDC; pfam00570 324831003013 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 324831003014 active site 324831003015 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 324831003016 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 324831003017 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 324831003018 active site 324831003019 DNA binding site [nucleotide binding] 324831003020 Int/Topo IB signature motif; other site 324831003021 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324831003022 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324831003023 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324831003024 dimerization interface [polypeptide binding]; other site 324831003025 EDD domain protein, DegV family; Region: DegV; TIGR00762 324831003026 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 324831003027 MarR family; Region: MarR_2; pfam12802 324831003028 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324831003029 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 324831003030 Domain of unknown function (DUF814); Region: DUF814; pfam05670 324831003031 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 324831003032 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 324831003033 ATP-grasp domain; Region: ATP-grasp_4; cl17255 324831003034 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 324831003035 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 324831003036 ATP-grasp domain; Region: ATP-grasp_4; cl17255 324831003037 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 324831003038 IMP binding site; other site 324831003039 dimer interface [polypeptide binding]; other site 324831003040 interdomain contacts; other site 324831003041 partial ornithine binding site; other site 324831003042 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 324831003043 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 324831003044 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 324831003045 conserved cys residue [active] 324831003046 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 324831003047 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324831003048 RNA binding surface [nucleotide binding]; other site 324831003049 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 324831003050 active site 324831003051 lipoprotein signal peptidase; Provisional; Region: PRK14797 324831003052 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 324831003053 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 324831003054 Potassium binding sites [ion binding]; other site 324831003055 Cesium cation binding sites [ion binding]; other site 324831003056 EDD domain protein, DegV family; Region: DegV; TIGR00762 324831003057 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 324831003058 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324831003059 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 324831003060 active site 324831003061 metal binding site [ion binding]; metal-binding site 324831003062 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 324831003063 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 324831003064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 324831003065 DivIVA protein; Region: DivIVA; pfam05103 324831003066 DivIVA domain; Region: DivI1A_domain; TIGR03544 324831003067 hypothetical protein; Provisional; Region: PRK13660 324831003068 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 324831003069 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 324831003070 Transglycosylase; Region: Transgly; pfam00912 324831003071 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 324831003072 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 324831003073 endonuclease III; Region: ENDO3c; smart00478 324831003074 minor groove reading motif; other site 324831003075 helix-hairpin-helix signature motif; other site 324831003076 substrate binding pocket [chemical binding]; other site 324831003077 active site 324831003078 Helix-turn-helix domain; Region: HTH_36; pfam13730 324831003079 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 324831003080 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 324831003081 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 324831003082 putative dimer interface [polypeptide binding]; other site 324831003083 putative anticodon binding site; other site 324831003084 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 324831003085 homodimer interface [polypeptide binding]; other site 324831003086 motif 1; other site 324831003087 motif 2; other site 324831003088 active site 324831003089 motif 3; other site 324831003090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 324831003091 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 324831003092 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 324831003093 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 324831003094 active site 324831003095 catalytic site [active] 324831003096 substrate binding site [chemical binding]; other site 324831003097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324831003098 ATP binding site [chemical binding]; other site 324831003099 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 324831003100 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 324831003101 DEAD/DEAH box helicase; Region: DEAD; pfam00270 324831003102 Family description; Region: UvrD_C_2; pfam13538 324831003103 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 324831003104 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 324831003105 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 324831003106 mevalonate kinase; Region: mevalon_kin; TIGR00549 324831003107 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 324831003108 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 324831003109 diphosphomevalonate decarboxylase; Region: PLN02407 324831003110 diphosphomevalonate decarboxylase; Region: PLN02407 324831003111 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 324831003112 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 324831003113 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 324831003114 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 324831003115 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 324831003116 homotetramer interface [polypeptide binding]; other site 324831003117 FMN binding site [chemical binding]; other site 324831003118 homodimer contacts [polypeptide binding]; other site 324831003119 putative active site [active] 324831003120 putative substrate binding site [chemical binding]; other site 324831003121 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324831003122 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 324831003123 Walker A/P-loop; other site 324831003124 ATP binding site [chemical binding]; other site 324831003125 Q-loop/lid; other site 324831003126 ABC transporter signature motif; other site 324831003127 Walker B; other site 324831003128 D-loop; other site 324831003129 H-loop/switch region; other site 324831003130 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324831003131 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 324831003132 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324831003133 Walker A/P-loop; other site 324831003134 ATP binding site [chemical binding]; other site 324831003135 Q-loop/lid; other site 324831003136 ABC transporter signature motif; other site 324831003137 Walker B; other site 324831003138 D-loop; other site 324831003139 H-loop/switch region; other site 324831003140 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 324831003141 Sugar transport protein; Region: Sugar_transport; pfam06800 324831003142 D-ribose pyranase; Provisional; Region: PRK11797 324831003143 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 324831003144 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 324831003145 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 324831003146 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 324831003147 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 324831003148 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 324831003149 addiction module toxin, RelE/StbE family; Region: RelE_StbE; TIGR02385 324831003150 Fic family protein [Function unknown]; Region: COG3177 324831003151 Fic/DOC family; Region: Fic; pfam02661 324831003152 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 324831003153 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 324831003154 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535 324831003155 metal binding site [ion binding]; metal-binding site 324831003156 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 324831003157 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324831003158 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324831003159 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 324831003160 Walker A/P-loop; other site 324831003161 ATP binding site [chemical binding]; other site 324831003162 Q-loop/lid; other site 324831003163 ABC transporter signature motif; other site 324831003164 Walker B; other site 324831003165 D-loop; other site 324831003166 H-loop/switch region; other site 324831003167 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 324831003168 putative FMN binding site [chemical binding]; other site 324831003169 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324831003170 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324831003171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324831003172 Walker A/P-loop; other site 324831003173 ATP binding site [chemical binding]; other site 324831003174 Q-loop/lid; other site 324831003175 ABC transporter signature motif; other site 324831003176 Walker B; other site 324831003177 D-loop; other site 324831003178 H-loop/switch region; other site 324831003179 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324831003180 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324831003181 non-specific DNA binding site [nucleotide binding]; other site 324831003182 salt bridge; other site 324831003183 sequence-specific DNA binding site [nucleotide binding]; other site 324831003184 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 324831003185 HflK protein; Region: hflK; TIGR01933 324831003186 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 324831003187 Protein of unknown function (DUF975); Region: DUF975; cl10504 324831003188 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 324831003189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 324831003190 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 324831003191 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 324831003192 putative active site [active] 324831003193 putative metal binding site [ion binding]; other site 324831003194 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 324831003195 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 324831003196 hypothetical protein; Provisional; Region: PRK09273 324831003197 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 324831003198 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 324831003199 dimer interface [polypeptide binding]; other site 324831003200 FMN binding site [chemical binding]; other site 324831003201 FMN-binding domain; Region: FMN_bind; pfam04205 324831003202 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 324831003203 Predicted oxidoreductase [General function prediction only]; Region: COG3573 324831003204 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324831003205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324831003206 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324831003207 dimerization interface [polypeptide binding]; other site 324831003208 homoserine kinase; Provisional; Region: PRK01212 324831003209 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 324831003210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 324831003211 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 324831003212 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 324831003213 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 324831003214 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 324831003215 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 324831003216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324831003217 catalytic residue [active] 324831003218 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 324831003219 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 324831003220 aspartate kinase; Reviewed; Region: PRK09034 324831003221 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 324831003222 putative catalytic residues [active] 324831003223 putative nucleotide binding site [chemical binding]; other site 324831003224 putative aspartate binding site [chemical binding]; other site 324831003225 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 324831003226 allosteric regulatory residue; other site 324831003227 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 324831003228 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 324831003229 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 324831003230 active site 324831003231 Zn binding site [ion binding]; other site 324831003232 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 324831003233 FtsX-like permease family; Region: FtsX; pfam02687 324831003234 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 324831003235 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324831003236 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324831003237 Walker A/P-loop; other site 324831003238 ATP binding site [chemical binding]; other site 324831003239 Q-loop/lid; other site 324831003240 ABC transporter signature motif; other site 324831003241 Walker B; other site 324831003242 D-loop; other site 324831003243 H-loop/switch region; other site 324831003244 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 324831003245 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 324831003246 active site 324831003247 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 324831003248 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 324831003249 Isochorismatase family; Region: Isochorismatase; pfam00857 324831003250 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 324831003251 catalytic triad [active] 324831003252 conserved cis-peptide bond; other site 324831003253 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 324831003254 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324831003255 active site 324831003256 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 324831003257 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 324831003258 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 324831003259 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 324831003260 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 324831003261 ATP-grasp domain; Region: ATP-grasp_4; cl17255 324831003262 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 324831003263 IMP binding site; other site 324831003264 dimer interface [polypeptide binding]; other site 324831003265 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 324831003266 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 324831003267 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 324831003268 catalytic site [active] 324831003269 subunit interface [polypeptide binding]; other site 324831003270 dihydroorotase; Validated; Region: pyrC; PRK09357 324831003271 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324831003272 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 324831003273 active site 324831003274 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 324831003275 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 324831003276 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 324831003277 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 324831003278 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324831003279 active site 324831003280 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 324831003281 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 324831003282 heterodimer interface [polypeptide binding]; other site 324831003283 active site 324831003284 FMN binding site [chemical binding]; other site 324831003285 homodimer interface [polypeptide binding]; other site 324831003286 substrate binding site [chemical binding]; other site 324831003287 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 324831003288 active site 324831003289 dimer interface [polypeptide binding]; other site 324831003290 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324831003291 active site 324831003292 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 324831003293 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 324831003294 sugar phosphate phosphatase; Provisional; Region: PRK10513 324831003295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831003296 active site 324831003297 motif I; other site 324831003298 motif II; other site 324831003299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831003300 Uncharacterized conserved protein [Function unknown]; Region: COG1434 324831003301 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 324831003302 putative active site [active] 324831003303 hypothetical protein; Provisional; Region: PRK00967 324831003304 Chitin synthase III catalytic subunit; Region: Chs3p; pfam12271 324831003305 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 324831003306 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 324831003307 Catalytic site [active] 324831003308 Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495 324831003309 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324831003310 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324831003311 Walker A/P-loop; other site 324831003312 ATP binding site [chemical binding]; other site 324831003313 Q-loop/lid; other site 324831003314 ABC transporter signature motif; other site 324831003315 Walker B; other site 324831003316 D-loop; other site 324831003317 H-loop/switch region; other site 324831003318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324831003319 DNA-binding site [nucleotide binding]; DNA binding site 324831003320 peptidase T; Region: peptidase-T; TIGR01882 324831003321 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 324831003322 metal binding site [ion binding]; metal-binding site 324831003323 dimer interface [polypeptide binding]; other site 324831003324 Uncharacterized conserved protein [Function unknown]; Region: COG0327 324831003325 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 324831003326 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 324831003327 Family of unknown function (DUF633); Region: DUF633; pfam04816 324831003328 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 324831003329 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 324831003330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324831003331 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 324831003332 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324831003333 DNA binding residues [nucleotide binding] 324831003334 DNA primase; Validated; Region: dnaG; PRK05667 324831003335 CHC2 zinc finger; Region: zf-CHC2; cl17510 324831003336 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 324831003337 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 324831003338 active site 324831003339 metal binding site [ion binding]; metal-binding site 324831003340 interdomain interaction site; other site 324831003341 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 324831003342 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 324831003343 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 324831003344 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 324831003345 motif 1; other site 324831003346 dimer interface [polypeptide binding]; other site 324831003347 active site 324831003348 motif 2; other site 324831003349 motif 3; other site 324831003350 Recombination protein O N terminal; Region: RecO_N; pfam11967 324831003351 DNA repair protein RecO; Region: reco; TIGR00613 324831003352 Recombination protein O C terminal; Region: RecO_C; pfam02565 324831003353 GTPase Era; Reviewed; Region: era; PRK00089 324831003354 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 324831003355 G1 box; other site 324831003356 GTP/Mg2+ binding site [chemical binding]; other site 324831003357 Switch I region; other site 324831003358 G2 box; other site 324831003359 Switch II region; other site 324831003360 G3 box; other site 324831003361 G4 box; other site 324831003362 G5 box; other site 324831003363 metal-binding heat shock protein; Provisional; Region: PRK00016 324831003364 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 324831003365 PhoH-like protein; Region: PhoH; pfam02562 324831003366 Yqey-like protein; Region: YqeY; pfam09424 324831003367 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 324831003368 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 324831003369 Uncharacterized conserved protein [Function unknown]; Region: COG1284 324831003370 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324831003371 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324831003372 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 324831003373 methionine sulfoxide reductase A; Provisional; Region: PRK14054 324831003374 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 324831003375 active site 324831003376 catalytic triad [active] 324831003377 oxyanion hole [active] 324831003378 methionine sulfoxide reductase B; Provisional; Region: PRK00222 324831003379 SelR domain; Region: SelR; pfam01641 324831003380 aromatic amino acid aminotransferase; Validated; Region: PRK07309 324831003381 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324831003382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324831003383 homodimer interface [polypeptide binding]; other site 324831003384 catalytic residue [active] 324831003385 Peptidase family M48; Region: Peptidase_M48; cl12018 324831003386 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 324831003387 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 324831003388 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 324831003389 NADP binding site [chemical binding]; other site 324831003390 active site 324831003391 putative substrate binding site [chemical binding]; other site 324831003392 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 324831003393 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 324831003394 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 324831003395 substrate binding site; other site 324831003396 tetramer interface; other site 324831003397 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 324831003398 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 324831003399 NAD binding site [chemical binding]; other site 324831003400 substrate binding site [chemical binding]; other site 324831003401 homodimer interface [polypeptide binding]; other site 324831003402 active site 324831003403 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 324831003404 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324831003405 DNA binding residues [nucleotide binding] 324831003406 dimer interface [polypeptide binding]; other site 324831003407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324831003408 S-adenosylmethionine binding site [chemical binding]; other site 324831003409 Abi-like protein; Region: Abi_2; pfam07751 324831003410 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 324831003411 Transposase; Region: DDE_Tnp_ISL3; pfam01610 324831003412 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 324831003413 Acyltransferase family; Region: Acyl_transf_3; pfam01757 324831003414 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 324831003415 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 324831003416 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 324831003417 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 324831003418 UDP-galactopyranose mutase; Region: GLF; pfam03275 324831003419 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 324831003420 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 324831003421 active site 324831003422 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 324831003423 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324831003424 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324831003425 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324831003426 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 324831003427 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 324831003428 Ligand binding site; other site 324831003429 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 324831003430 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 324831003431 GDP-Fucose binding site [chemical binding]; other site 324831003432 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101 324831003433 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 324831003434 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 324831003435 Bacterial sugar transferase; Region: Bac_transf; pfam02397 324831003436 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 324831003437 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 324831003438 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324831003439 Chain length determinant protein; Region: Wzz; cl15801 324831003440 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 324831003441 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 324831003442 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 324831003443 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 324831003444 catalytic residues [active] 324831003445 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 324831003446 Low molecular weight phosphatase family; Region: LMWPc; cd00115 324831003447 active site 324831003448 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 324831003449 G1 box; other site 324831003450 GTP/Mg2+ binding site [chemical binding]; other site 324831003451 Switch I region; other site 324831003452 G2 box; other site 324831003453 G3 box; other site 324831003454 Switch II region; other site 324831003455 G4 box; other site 324831003456 G5 box; other site 324831003457 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 324831003458 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 324831003459 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324831003460 Walker A motif; other site 324831003461 ATP binding site [chemical binding]; other site 324831003462 Walker B motif; other site 324831003463 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 324831003464 trigger factor; Provisional; Region: tig; PRK01490 324831003465 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 324831003466 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 324831003467 elongation factor Tu; Reviewed; Region: PRK00049 324831003468 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 324831003469 G1 box; other site 324831003470 GEF interaction site [polypeptide binding]; other site 324831003471 GTP/Mg2+ binding site [chemical binding]; other site 324831003472 Switch I region; other site 324831003473 G2 box; other site 324831003474 G3 box; other site 324831003475 Switch II region; other site 324831003476 G4 box; other site 324831003477 G5 box; other site 324831003478 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 324831003479 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 324831003480 Antibiotic Binding Site [chemical binding]; other site 324831003481 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 324831003482 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 324831003483 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 324831003484 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 324831003485 16S/18S rRNA binding site [nucleotide binding]; other site 324831003486 S13e-L30e interaction site [polypeptide binding]; other site 324831003487 25S rRNA binding site [nucleotide binding]; other site 324831003488 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 324831003489 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 324831003490 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 324831003491 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 324831003492 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 324831003493 Competence protein; Region: Competence; pfam03772 324831003494 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 324831003495 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 324831003496 SLBB domain; Region: SLBB; pfam10531 324831003497 comEA protein; Region: comE; TIGR01259 324831003498 Helix-hairpin-helix motif; Region: HHH; pfam00633 324831003499 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 324831003500 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 324831003501 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 324831003502 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 324831003503 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 324831003504 active site 324831003505 (T/H)XGH motif; other site 324831003506 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 324831003507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324831003508 S-adenosylmethionine binding site [chemical binding]; other site 324831003509 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 324831003510 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 324831003511 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 324831003512 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 324831003513 putative GEF interaction site [polypeptide binding]; other site 324831003514 G1 box; other site 324831003515 GTP/Mg2+ binding site [chemical binding]; other site 324831003516 Switch I region; other site 324831003517 G2 box; other site 324831003518 G3 box; other site 324831003519 Switch II region; other site 324831003520 G4 box; other site 324831003521 G5 box; other site 324831003522 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 324831003523 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 324831003524 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 324831003525 active site 324831003526 catalytic residues [active] 324831003527 metal binding site [ion binding]; metal-binding site 324831003528 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 324831003529 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 324831003530 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 324831003531 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 324831003532 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 324831003533 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 324831003534 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 324831003535 AAA domain; Region: AAA_30; pfam13604 324831003536 Family description; Region: UvrD_C_2; pfam13538 324831003537 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 324831003538 binding surface 324831003539 TPR motif; other site 324831003540 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 324831003541 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324831003542 binding surface 324831003543 TPR motif; other site 324831003544 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324831003545 catalytic core [active] 324831003546 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 324831003547 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 324831003548 Putative amino acid metabolism; Region: DUF1831; pfam08866 324831003549 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 324831003550 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 324831003551 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324831003552 catalytic residue [active] 324831003553 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 324831003554 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 324831003555 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 324831003556 dimer interface [polypeptide binding]; other site 324831003557 ADP-ribose binding site [chemical binding]; other site 324831003558 active site 324831003559 nudix motif; other site 324831003560 metal binding site [ion binding]; metal-binding site 324831003561 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 324831003562 DNA-binding site [nucleotide binding]; DNA binding site 324831003563 RNA-binding motif; other site 324831003564 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 324831003565 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324831003566 active site 324831003567 HIGH motif; other site 324831003568 nucleotide binding site [chemical binding]; other site 324831003569 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 324831003570 active site 324831003571 KMSKS motif; other site 324831003572 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 324831003573 tRNA binding surface [nucleotide binding]; other site 324831003574 anticodon binding site; other site 324831003575 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 324831003576 DivIVA protein; Region: DivIVA; pfam05103 324831003577 DivIVA domain; Region: DivI1A_domain; TIGR03544 324831003578 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 324831003579 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324831003580 RNA binding surface [nucleotide binding]; other site 324831003581 YGGT family; Region: YGGT; pfam02325 324831003582 Protein of unknown function (DUF552); Region: DUF552; cl00775 324831003583 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 324831003584 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 324831003585 nucleotide binding site [chemical binding]; other site 324831003586 SulA interaction site; other site 324831003587 cell division protein FtsA; Region: ftsA; TIGR01174 324831003588 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 324831003589 nucleotide binding site [chemical binding]; other site 324831003590 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 324831003591 Cell division protein FtsA; Region: FtsA; pfam14450 324831003592 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 324831003593 Cell division protein FtsQ; Region: FtsQ; pfam03799 324831003594 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 324831003595 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 324831003596 active site 324831003597 homodimer interface [polypeptide binding]; other site 324831003598 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 324831003599 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324831003600 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324831003601 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 324831003602 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 324831003603 Mg++ binding site [ion binding]; other site 324831003604 putative catalytic motif [active] 324831003605 putative substrate binding site [chemical binding]; other site 324831003606 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 324831003607 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 324831003608 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 324831003609 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 324831003610 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 324831003611 cell division protein FtsL; Region: ftsL_broad; TIGR02209 324831003612 MraW methylase family; Region: Methyltransf_5; pfam01795 324831003613 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 324831003614 cell division protein MraZ; Reviewed; Region: PRK00326 324831003615 MraZ protein; Region: MraZ; pfam02381 324831003616 MraZ protein; Region: MraZ; pfam02381 324831003617 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 324831003618 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 324831003619 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 324831003620 rod shape-determining protein MreC; Provisional; Region: PRK13922 324831003621 rod shape-determining protein MreC; Region: MreC; pfam04085 324831003622 rod shape-determining protein MreB; Provisional; Region: PRK13927 324831003623 MreB and similar proteins; Region: MreB_like; cd10225 324831003624 nucleotide binding site [chemical binding]; other site 324831003625 Mg binding site [ion binding]; other site 324831003626 putative protofilament interaction site [polypeptide binding]; other site 324831003627 RodZ interaction site [polypeptide binding]; other site 324831003628 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 324831003629 MPN+ (JAMM) motif; other site 324831003630 Zinc-binding site [ion binding]; other site 324831003631 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 324831003632 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831003633 motif II; other site 324831003634 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 324831003635 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324831003636 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324831003637 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 324831003638 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324831003639 active site 324831003640 HIGH motif; other site 324831003641 nucleotide binding site [chemical binding]; other site 324831003642 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 324831003643 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 324831003644 active site 324831003645 KMSKS motif; other site 324831003646 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 324831003647 tRNA binding surface [nucleotide binding]; other site 324831003648 anticodon binding site; other site 324831003649 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 324831003650 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 324831003651 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 324831003652 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324831003653 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 324831003654 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831003655 motif II; other site 324831003656 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 324831003657 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 324831003658 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 324831003659 active site 324831003660 catalytic site [active] 324831003661 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 324831003662 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324831003663 RNA binding surface [nucleotide binding]; other site 324831003664 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 324831003665 active site 324831003666 uracil binding [chemical binding]; other site 324831003667 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 324831003668 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 324831003669 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 324831003670 Ligand Binding Site [chemical binding]; other site 324831003671 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 324831003672 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 324831003673 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324831003674 catalytic residue [active] 324831003675 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 324831003676 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 324831003677 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 324831003678 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324831003679 RNA binding surface [nucleotide binding]; other site 324831003680 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 324831003681 recombination factor protein RarA; Reviewed; Region: PRK13342 324831003682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324831003683 Walker A motif; other site 324831003684 ATP binding site [chemical binding]; other site 324831003685 Walker B motif; other site 324831003686 arginine finger; other site 324831003687 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 324831003688 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 324831003689 Ligand Binding Site [chemical binding]; other site 324831003690 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 324831003691 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 324831003692 hypothetical protein; Provisional; Region: PRK14379 324831003693 rod shape-determining protein MreB; Provisional; Region: PRK13930 324831003694 MreB and similar proteins; Region: MreB_like; cd10225 324831003695 nucleotide binding site [chemical binding]; other site 324831003696 Mg binding site [ion binding]; other site 324831003697 putative protofilament interaction site [polypeptide binding]; other site 324831003698 RodZ interaction site [polypeptide binding]; other site 324831003699 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 324831003700 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 324831003701 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 324831003702 gamma subunit interface [polypeptide binding]; other site 324831003703 epsilon subunit interface [polypeptide binding]; other site 324831003704 LBP interface [polypeptide binding]; other site 324831003705 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 324831003706 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 324831003707 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 324831003708 alpha subunit interaction interface [polypeptide binding]; other site 324831003709 Walker A motif; other site 324831003710 ATP binding site [chemical binding]; other site 324831003711 Walker B motif; other site 324831003712 inhibitor binding site; inhibition site 324831003713 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 324831003714 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 324831003715 core domain interface [polypeptide binding]; other site 324831003716 delta subunit interface [polypeptide binding]; other site 324831003717 epsilon subunit interface [polypeptide binding]; other site 324831003718 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 324831003719 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 324831003720 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 324831003721 beta subunit interaction interface [polypeptide binding]; other site 324831003722 Walker A motif; other site 324831003723 ATP binding site [chemical binding]; other site 324831003724 Walker B motif; other site 324831003725 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 324831003726 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 324831003727 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 324831003728 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 324831003729 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 324831003730 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 324831003731 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324831003732 active site 324831003733 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 324831003734 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 324831003735 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 324831003736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324831003737 S-adenosylmethionine binding site [chemical binding]; other site 324831003738 peptide chain release factor 1; Validated; Region: prfA; PRK00591 324831003739 This domain is found in peptide chain release factors; Region: PCRF; smart00937 324831003740 RF-1 domain; Region: RF-1; pfam00472 324831003741 thymidine kinase; Provisional; Region: PRK04296 324831003742 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 324831003743 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324831003744 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 324831003745 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 324831003746 Beta-lactamase; Region: Beta-lactamase; pfam00144 324831003747 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 324831003748 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 324831003749 active site 324831003750 dimer interface [polypeptide binding]; other site 324831003751 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 324831003752 dimer interface [polypeptide binding]; other site 324831003753 active site 324831003754 VanZ like family; Region: VanZ; pfam04892 324831003755 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 324831003756 Sulfatase; Region: Sulfatase; pfam00884 324831003757 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324831003758 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324831003759 dimerization interface [polypeptide binding]; other site 324831003760 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324831003761 dimer interface [polypeptide binding]; other site 324831003762 phosphorylation site [posttranslational modification] 324831003763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324831003764 ATP binding site [chemical binding]; other site 324831003765 Mg2+ binding site [ion binding]; other site 324831003766 G-X-G motif; other site 324831003767 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324831003768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324831003769 active site 324831003770 phosphorylation site [posttranslational modification] 324831003771 intermolecular recognition site; other site 324831003772 dimerization interface [polypeptide binding]; other site 324831003773 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324831003774 DNA binding site [nucleotide binding] 324831003775 SdpI/YhfL protein family; Region: SdpI; pfam13630 324831003776 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 324831003777 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 324831003778 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 324831003779 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 324831003780 propionate/acetate kinase; Provisional; Region: PRK12379 324831003781 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 324831003782 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 324831003783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324831003784 S-adenosylmethionine binding site [chemical binding]; other site 324831003785 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 324831003786 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 324831003787 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 324831003788 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 324831003789 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 324831003790 Type II/IV secretion system protein; Region: T2SE; pfam00437 324831003791 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 324831003792 Walker A motif; other site 324831003793 ATP binding site [chemical binding]; other site 324831003794 Walker B motif; other site 324831003795 hypothetical protein; Validated; Region: PRK00110 324831003796 Predicted integral membrane protein [Function unknown]; Region: COG5652 324831003797 Flavoprotein; Region: Flavoprotein; pfam02441 324831003798 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 324831003799 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 324831003800 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324831003801 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 324831003802 intersubunit interface [polypeptide binding]; other site 324831003803 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 324831003804 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 324831003805 TIGR03545 family protein; Region: TIGR03545 324831003806 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324831003807 camphor resistance protein CrcB; Provisional; Region: PRK14220 324831003808 CrcB-like protein; Region: CRCB; pfam02537 324831003809 sugar phosphate phosphatase; Provisional; Region: PRK10513 324831003810 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831003811 active site 324831003812 motif I; other site 324831003813 motif II; other site 324831003814 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 324831003815 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 324831003816 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 324831003817 active site 324831003818 substrate binding site [chemical binding]; other site 324831003819 metal binding site [ion binding]; metal-binding site 324831003820 YbbR-like protein; Region: YbbR; pfam07949 324831003821 YbbR-like protein; Region: YbbR; pfam07949 324831003822 YbbR-like protein; Region: YbbR; pfam07949 324831003823 Uncharacterized conserved protein [Function unknown]; Region: COG1624 324831003824 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 324831003825 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 324831003826 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 324831003827 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324831003828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831003829 dimer interface [polypeptide binding]; other site 324831003830 ABC-ATPase subunit interface; other site 324831003831 putative PBP binding loops; other site 324831003832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831003833 dimer interface [polypeptide binding]; other site 324831003834 conserved gate region; other site 324831003835 putative PBP binding loops; other site 324831003836 ABC-ATPase subunit interface; other site 324831003837 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 324831003838 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 324831003839 Walker A/P-loop; other site 324831003840 ATP binding site [chemical binding]; other site 324831003841 Q-loop/lid; other site 324831003842 ABC transporter signature motif; other site 324831003843 Walker B; other site 324831003844 D-loop; other site 324831003845 H-loop/switch region; other site 324831003846 TOBE domain; Region: TOBE_2; pfam08402 324831003847 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 324831003848 FAD binding domain; Region: FAD_binding_4; pfam01565 324831003849 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 324831003850 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 324831003851 active site 324831003852 catalytic site [active] 324831003853 substrate binding site [chemical binding]; other site 324831003854 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 324831003855 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 324831003856 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 324831003857 ligand binding site [chemical binding]; other site 324831003858 active site 324831003859 UGI interface [polypeptide binding]; other site 324831003860 catalytic site [active] 324831003861 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831003862 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324831003863 active site 324831003864 motif I; other site 324831003865 motif II; other site 324831003866 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 324831003867 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324831003868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324831003869 Coenzyme A binding pocket [chemical binding]; other site 324831003870 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 324831003871 SmpB-tmRNA interface; other site 324831003872 ribonuclease R; Region: RNase_R; TIGR02063 324831003873 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 324831003874 RNB domain; Region: RNB; pfam00773 324831003875 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 324831003876 RNA binding site [nucleotide binding]; other site 324831003877 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 324831003878 enolase; Provisional; Region: eno; PRK00077 324831003879 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 324831003880 dimer interface [polypeptide binding]; other site 324831003881 metal binding site [ion binding]; metal-binding site 324831003882 substrate binding pocket [chemical binding]; other site 324831003883 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 324831003884 triosephosphate isomerase; Provisional; Region: PRK14567 324831003885 substrate binding site [chemical binding]; other site 324831003886 dimer interface [polypeptide binding]; other site 324831003887 catalytic triad [active] 324831003888 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 324831003889 Phosphoglycerate kinase; Region: PGK; pfam00162 324831003890 substrate binding site [chemical binding]; other site 324831003891 hinge regions; other site 324831003892 ADP binding site [chemical binding]; other site 324831003893 catalytic site [active] 324831003894 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 324831003895 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 324831003896 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 324831003897 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 324831003898 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 324831003899 Amino acid permease; Region: AA_permease_2; pfam13520 324831003900 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 324831003901 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 324831003902 oligomer interface [polypeptide binding]; other site 324831003903 active site residues [active] 324831003904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 324831003905 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 324831003906 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 324831003907 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 324831003908 phosphate binding site [ion binding]; other site 324831003909 putative substrate binding pocket [chemical binding]; other site 324831003910 dimer interface [polypeptide binding]; other site 324831003911 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 324831003912 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 324831003913 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 324831003914 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 324831003915 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 324831003916 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 324831003917 excinuclease ABC subunit B; Provisional; Region: PRK05298 324831003918 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 324831003919 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324831003920 ATP-binding site [chemical binding]; other site 324831003921 ATP binding site [chemical binding]; other site 324831003922 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324831003923 nucleotide binding region [chemical binding]; other site 324831003924 ATP-binding site [chemical binding]; other site 324831003925 Ultra-violet resistance protein B; Region: UvrB; pfam12344 324831003926 UvrB/uvrC motif; Region: UVR; pfam02151 324831003927 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 324831003928 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 324831003929 active site 324831003930 substrate binding site [chemical binding]; other site 324831003931 metal binding site [ion binding]; metal-binding site 324831003932 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 324831003933 active site 324831003934 catalytic residues [active] 324831003935 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 324831003936 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 324831003937 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 324831003938 galactokinase; Provisional; Region: PRK05322 324831003939 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 324831003940 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 324831003941 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324831003942 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324831003943 DNA binding site [nucleotide binding] 324831003944 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 324831003945 putative ligand binding site [chemical binding]; other site 324831003946 putative dimerization interface [polypeptide binding]; other site 324831003947 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 324831003948 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 324831003949 NAD binding site [chemical binding]; other site 324831003950 homodimer interface [polypeptide binding]; other site 324831003951 active site 324831003952 substrate binding site [chemical binding]; other site 324831003953 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 324831003954 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 324831003955 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324831003956 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 324831003957 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 324831003958 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 324831003959 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 324831003960 HPr kinase/phosphorylase; Provisional; Region: PRK05428 324831003961 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 324831003962 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 324831003963 Hpr binding site; other site 324831003964 active site 324831003965 homohexamer subunit interaction site [polypeptide binding]; other site 324831003966 peptide chain release factor 2; Provisional; Region: PRK05589 324831003967 PCRF domain; Region: PCRF; pfam03462 324831003968 RF-1 domain; Region: RF-1; pfam00472 324831003969 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 324831003970 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 324831003971 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324831003972 nucleotide binding region [chemical binding]; other site 324831003973 ATP-binding site [chemical binding]; other site 324831003974 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 324831003975 30S subunit binding site; other site 324831003976 comF family protein; Region: comF; TIGR00201 324831003977 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324831003978 active site 324831003979 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 324831003980 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324831003981 ATP binding site [chemical binding]; other site 324831003982 putative Mg++ binding site [ion binding]; other site 324831003983 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 324831003984 nucleotide binding region [chemical binding]; other site 324831003985 ATP-binding site [chemical binding]; other site 324831003986 Uncharacterized conserved protein [Function unknown]; Region: COG1739 324831003987 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 324831003988 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 324831003989 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 324831003990 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 324831003991 Mg++ binding site [ion binding]; other site 324831003992 putative catalytic motif [active] 324831003993 substrate binding site [chemical binding]; other site 324831003994 phosphodiesterase; Provisional; Region: PRK12704 324831003995 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324831003996 Zn2+ binding site [ion binding]; other site 324831003997 Mg2+ binding site [ion binding]; other site 324831003998 recombinase A; Provisional; Region: recA; PRK09354 324831003999 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 324831004000 hexamer interface [polypeptide binding]; other site 324831004001 Walker A motif; other site 324831004002 ATP binding site [chemical binding]; other site 324831004003 Walker B motif; other site 324831004004 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 324831004005 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 324831004006 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324831004007 non-specific DNA binding site [nucleotide binding]; other site 324831004008 salt bridge; other site 324831004009 sequence-specific DNA binding site [nucleotide binding]; other site 324831004010 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324831004011 classical (c) SDRs; Region: SDR_c; cd05233 324831004012 NAD(P) binding site [chemical binding]; other site 324831004013 active site 324831004014 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 324831004015 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 324831004016 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 324831004017 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 324831004018 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499 324831004019 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 324831004020 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 324831004021 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 324831004022 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 324831004023 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 324831004024 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 324831004025 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 324831004026 Domain of unknown function DUF20; Region: UPF0118; pfam01594 324831004027 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 324831004028 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 324831004029 AAA ATPase domain; Region: AAA_16; pfam13191 324831004030 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 324831004031 Uncharacterized conserved protein [Function unknown]; Region: COG3410 324831004032 myosin-cross-reactive antigen; Provisional; Region: PRK13977 324831004033 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 324831004034 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 324831004035 active site 324831004036 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 324831004037 ATP-NAD kinase; Region: NAD_kinase; pfam01513 324831004038 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 324831004039 synthetase active site [active] 324831004040 NTP binding site [chemical binding]; other site 324831004041 metal binding site [ion binding]; metal-binding site 324831004042 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 324831004043 putative active site [active] 324831004044 putative metal binding residues [ion binding]; other site 324831004045 signature motif; other site 324831004046 putative triphosphate binding site [ion binding]; other site 324831004047 Thioredoxin; Region: Thioredoxin_5; pfam13743 324831004048 Competence protein CoiA-like family; Region: CoiA; cl11541 324831004049 adaptor protein; Provisional; Region: PRK02315 324831004050 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 324831004051 ArsC family; Region: ArsC; pfam03960 324831004052 putative catalytic residues [active] 324831004053 thiol/disulfide switch; other site 324831004054 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 324831004055 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 324831004056 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 324831004057 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 324831004058 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 324831004059 dimerization domain swap beta strand [polypeptide binding]; other site 324831004060 regulatory protein interface [polypeptide binding]; other site 324831004061 active site 324831004062 regulatory phosphorylation site [posttranslational modification]; other site 324831004063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324831004064 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 324831004065 Walker A motif; other site 324831004066 ATP binding site [chemical binding]; other site 324831004067 Walker B motif; other site 324831004068 arginine finger; other site 324831004069 UvrB/uvrC motif; Region: UVR; pfam02151 324831004070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324831004071 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 324831004072 Walker A motif; other site 324831004073 ATP binding site [chemical binding]; other site 324831004074 Walker B motif; other site 324831004075 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 324831004076 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 324831004077 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 324831004078 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 324831004079 G1 box; other site 324831004080 putative GEF interaction site [polypeptide binding]; other site 324831004081 GTP/Mg2+ binding site [chemical binding]; other site 324831004082 Switch I region; other site 324831004083 G2 box; other site 324831004084 G3 box; other site 324831004085 Switch II region; other site 324831004086 G4 box; other site 324831004087 G5 box; other site 324831004088 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 324831004089 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 324831004090 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 324831004091 Transporter associated domain; Region: CorC_HlyC; pfam03471 324831004092 hypothetical protein; Provisional; Region: PRK13662 324831004093 recombination regulator RecX; Provisional; Region: recX; PRK14135 324831004094 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 324831004095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324831004096 S-adenosylmethionine binding site [chemical binding]; other site 324831004097 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 324831004098 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 324831004099 dimer interface [polypeptide binding]; other site 324831004100 active site 324831004101 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 324831004102 homodimer interface [polypeptide binding]; other site 324831004103 catalytic residues [active] 324831004104 NAD binding site [chemical binding]; other site 324831004105 substrate binding pocket [chemical binding]; other site 324831004106 flexible flap; other site 324831004107 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 324831004108 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 324831004109 dimer interface [polypeptide binding]; other site 324831004110 active site 324831004111 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 324831004112 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 324831004113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831004114 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324831004115 active site 324831004116 motif I; other site 324831004117 motif II; other site 324831004118 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 324831004119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831004120 putative substrate translocation pore; other site 324831004121 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324831004122 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 324831004123 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 324831004124 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 324831004125 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 324831004126 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 324831004127 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 324831004128 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 324831004129 active site residue [active] 324831004130 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 324831004131 Rhomboid family; Region: Rhomboid; pfam01694 324831004132 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 324831004133 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 324831004134 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 324831004135 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 324831004136 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 324831004137 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 324831004138 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 324831004139 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 324831004140 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 324831004141 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 324831004142 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 324831004143 YceG-like family; Region: YceG; pfam02618 324831004144 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 324831004145 dimerization interface [polypeptide binding]; other site 324831004146 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 324831004147 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 324831004148 putative tRNA-binding site [nucleotide binding]; other site 324831004149 B3/4 domain; Region: B3_4; pfam03483 324831004150 tRNA synthetase B5 domain; Region: B5; smart00874 324831004151 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 324831004152 dimer interface [polypeptide binding]; other site 324831004153 motif 1; other site 324831004154 motif 3; other site 324831004155 motif 2; other site 324831004156 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 324831004157 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 324831004158 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 324831004159 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 324831004160 dimer interface [polypeptide binding]; other site 324831004161 motif 1; other site 324831004162 active site 324831004163 motif 2; other site 324831004164 motif 3; other site 324831004165 Predicted transcriptional regulators [Transcription]; Region: COG1733 324831004166 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 324831004167 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 324831004168 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 324831004169 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 324831004170 Acylphosphatase; Region: Acylphosphatase; pfam00708 324831004171 OxaA-like protein precursor; Provisional; Region: PRK02463 324831004172 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 324831004173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324831004174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324831004175 dimerization interface [polypeptide binding]; other site 324831004176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324831004177 dimer interface [polypeptide binding]; other site 324831004178 phosphorylation site [posttranslational modification] 324831004179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324831004180 ATP binding site [chemical binding]; other site 324831004181 Mg2+ binding site [ion binding]; other site 324831004182 G-X-G motif; other site 324831004183 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324831004184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324831004185 active site 324831004186 phosphorylation site [posttranslational modification] 324831004187 intermolecular recognition site; other site 324831004188 dimerization interface [polypeptide binding]; other site 324831004189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324831004190 DNA binding site [nucleotide binding] 324831004191 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 324831004192 hypothetical protein; Provisional; Region: PRK13670 324831004193 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 324831004194 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 324831004195 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324831004196 Zn2+ binding site [ion binding]; other site 324831004197 Mg2+ binding site [ion binding]; other site 324831004198 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 324831004199 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 324831004200 active site 324831004201 (T/H)XGH motif; other site 324831004202 GTPase YqeH; Provisional; Region: PRK13796 324831004203 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 324831004204 GTP/Mg2+ binding site [chemical binding]; other site 324831004205 G4 box; other site 324831004206 G5 box; other site 324831004207 G1 box; other site 324831004208 Switch I region; other site 324831004209 G2 box; other site 324831004210 G3 box; other site 324831004211 Switch II region; other site 324831004212 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 324831004213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831004214 active site 324831004215 motif I; other site 324831004216 motif II; other site 324831004217 adenosine deaminase; Provisional; Region: PRK09358 324831004218 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 324831004219 active site 324831004220 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 324831004221 23S rRNA binding site [nucleotide binding]; other site 324831004222 L21 binding site [polypeptide binding]; other site 324831004223 L13 binding site [polypeptide binding]; other site 324831004224 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 324831004225 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 324831004226 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 324831004227 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 324831004228 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 324831004229 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324831004230 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324831004231 Walker A/P-loop; other site 324831004232 ATP binding site [chemical binding]; other site 324831004233 Q-loop/lid; other site 324831004234 ABC transporter signature motif; other site 324831004235 Walker B; other site 324831004236 D-loop; other site 324831004237 H-loop/switch region; other site 324831004238 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 324831004239 LytTr DNA-binding domain; Region: LytTR; smart00850 324831004240 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 324831004241 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 324831004242 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 324831004243 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 324831004244 active site 324831004245 dimer interface [polypeptide binding]; other site 324831004246 motif 1; other site 324831004247 motif 2; other site 324831004248 motif 3; other site 324831004249 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 324831004250 anticodon binding site; other site 324831004251 primosomal protein DnaI; Reviewed; Region: PRK08939 324831004252 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 324831004253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324831004254 Walker A motif; other site 324831004255 ATP binding site [chemical binding]; other site 324831004256 Walker B motif; other site 324831004257 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 324831004258 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 324831004259 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 324831004260 ATP cone domain; Region: ATP-cone; pfam03477 324831004261 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 324831004262 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 324831004263 CoA-binding site [chemical binding]; other site 324831004264 ATP-binding [chemical binding]; other site 324831004265 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 324831004266 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 324831004267 DNA binding site [nucleotide binding] 324831004268 catalytic residue [active] 324831004269 H2TH interface [polypeptide binding]; other site 324831004270 putative catalytic residues [active] 324831004271 turnover-facilitating residue; other site 324831004272 intercalation triad [nucleotide binding]; other site 324831004273 8OG recognition residue [nucleotide binding]; other site 324831004274 putative reading head residues; other site 324831004275 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 324831004276 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 324831004277 DNA polymerase I; Provisional; Region: PRK05755 324831004278 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 324831004279 active site 324831004280 metal binding site 1 [ion binding]; metal-binding site 324831004281 putative 5' ssDNA interaction site; other site 324831004282 metal binding site 3; metal-binding site 324831004283 metal binding site 2 [ion binding]; metal-binding site 324831004284 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 324831004285 putative DNA binding site [nucleotide binding]; other site 324831004286 putative metal binding site [ion binding]; other site 324831004287 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 324831004288 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 324831004289 active site 324831004290 DNA binding site [nucleotide binding] 324831004291 catalytic site [active] 324831004292 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 324831004293 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 324831004294 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324831004295 catalytic residue [active] 324831004296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831004297 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324831004298 putative substrate translocation pore; other site 324831004299 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324831004300 MarR family; Region: MarR_2; pfam12802 324831004301 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 324831004302 UTRA domain; Region: UTRA; pfam07702 324831004303 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 324831004304 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 324831004305 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324831004306 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324831004307 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 324831004308 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 324831004309 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 324831004310 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 324831004311 active site 324831004312 dimer interface [polypeptide binding]; other site 324831004313 catalytic nucleophile [active] 324831004314 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 324831004315 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 324831004316 active site 324831004317 metal binding site [ion binding]; metal-binding site 324831004318 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 324831004319 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324831004320 DNA-binding site [nucleotide binding]; DNA binding site 324831004321 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 324831004322 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 324831004323 putative tRNA-binding site [nucleotide binding]; other site 324831004324 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 324831004325 catalytic residues [active] 324831004326 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 324831004327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324831004328 S-adenosylmethionine binding site [chemical binding]; other site 324831004329 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 324831004330 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324831004331 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324831004332 Walker A/P-loop; other site 324831004333 ATP binding site [chemical binding]; other site 324831004334 Q-loop/lid; other site 324831004335 ABC transporter signature motif; other site 324831004336 Walker B; other site 324831004337 D-loop; other site 324831004338 H-loop/switch region; other site 324831004339 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 324831004340 HIT family signature motif; other site 324831004341 catalytic residue [active] 324831004342 YtxH-like protein; Region: YtxH; cl02079 324831004343 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 324831004344 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 324831004345 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 324831004346 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 324831004347 generic binding surface II; other site 324831004348 generic binding surface I; other site 324831004349 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324831004350 Zn2+ binding site [ion binding]; other site 324831004351 Mg2+ binding site [ion binding]; other site 324831004352 P-loop containing region of AAA domain; Region: AAA_29; cl17516 324831004353 AAA domain; Region: AAA_23; pfam13476 324831004354 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 324831004355 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 324831004356 active site 324831004357 metal binding site [ion binding]; metal-binding site 324831004358 DNA binding site [nucleotide binding] 324831004359 hypothetical protein; Provisional; Region: PRK13676 324831004360 Transglycosylase; Region: Transgly; pfam00912 324831004361 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 324831004362 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 324831004363 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 324831004364 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 324831004365 active site 324831004366 DNA polymerase IV; Reviewed; Region: PRK03103 324831004367 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 324831004368 active site 324831004369 DNA binding site [nucleotide binding] 324831004370 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 324831004371 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 324831004372 nudix motif; other site 324831004373 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 324831004374 active site 324831004375 ATP binding site [chemical binding]; other site 324831004376 Phosphotransferase enzyme family; Region: APH; pfam01636 324831004377 antibiotic binding site [chemical binding]; other site 324831004378 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 324831004379 Beta-lactamase; Region: Beta-lactamase; pfam00144 324831004380 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 324831004381 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324831004382 ATP binding site [chemical binding]; other site 324831004383 putative Mg++ binding site [ion binding]; other site 324831004384 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324831004385 nucleotide binding region [chemical binding]; other site 324831004386 ATP-binding site [chemical binding]; other site 324831004387 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 324831004388 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 324831004389 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 324831004390 non-specific DNA binding site [nucleotide binding]; other site 324831004391 salt bridge; other site 324831004392 sequence-specific DNA binding site [nucleotide binding]; other site 324831004393 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 324831004394 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 324831004395 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 324831004396 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 324831004397 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 324831004398 active site 324831004399 DNA binding site [nucleotide binding] 324831004400 catalytic site [active] 324831004401 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 324831004402 D5 N terminal like; Region: D5_N; smart00885 324831004403 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 324831004404 VRR-NUC domain; Region: VRR_NUC; pfam08774 324831004405 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324831004406 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 324831004407 ATP binding site [chemical binding]; other site 324831004408 putative Mg++ binding site [ion binding]; other site 324831004409 Phage terminase, small subunit; Region: Terminase_4; pfam05119 324831004410 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 324831004411 ParB-like nuclease domain; Region: ParBc; pfam02195 324831004412 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 324831004413 DNA methylase; Region: N6_N4_Mtase; pfam01555 324831004414 Phage portal protein; Region: Phage_portal; pfam04860 324831004415 Phage-related protein [Function unknown]; Region: COG4695 324831004416 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 324831004417 oligomer interface [polypeptide binding]; other site 324831004418 active site residues [active] 324831004419 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 324831004420 Phage capsid family; Region: Phage_capsid; pfam05065 324831004421 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 324831004422 Holin family; Region: Phage_holin_4; pfam05105 324831004423 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 324831004424 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 324831004425 active site 324831004426 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; smart01095 324831004427 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; smart01095 324831004428 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 324831004429 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 324831004430 catalytic residues [active] 324831004431 catalytic nucleophile [active] 324831004432 Recombinase; Region: Recombinase; pfam07508 324831004433 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 324831004434 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 324831004435 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 324831004436 catalytic residues [active] 324831004437 Recombinase; Region: Recombinase; pfam07508 324831004438 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 324831004439 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 324831004440 TRAM domain; Region: TRAM; pfam01938 324831004441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324831004442 S-adenosylmethionine binding site [chemical binding]; other site 324831004443 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 324831004444 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 324831004445 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 324831004446 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 324831004447 Walker A/P-loop; other site 324831004448 ATP binding site [chemical binding]; other site 324831004449 Q-loop/lid; other site 324831004450 ABC transporter signature motif; other site 324831004451 Walker B; other site 324831004452 D-loop; other site 324831004453 H-loop/switch region; other site 324831004454 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 324831004455 Uncharacterized conserved protein [Function unknown]; Region: COG1912 324831004456 hypothetical protein; Provisional; Region: PRK13661 324831004457 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324831004458 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 324831004459 Walker A/P-loop; other site 324831004460 ATP binding site [chemical binding]; other site 324831004461 Q-loop/lid; other site 324831004462 ABC transporter signature motif; other site 324831004463 Walker B; other site 324831004464 D-loop; other site 324831004465 H-loop/switch region; other site 324831004466 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 324831004467 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324831004468 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 324831004469 Walker A/P-loop; other site 324831004470 ATP binding site [chemical binding]; other site 324831004471 Q-loop/lid; other site 324831004472 ABC transporter signature motif; other site 324831004473 Walker B; other site 324831004474 D-loop; other site 324831004475 H-loop/switch region; other site 324831004476 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 324831004477 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 324831004478 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 324831004479 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 324831004480 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 324831004481 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 324831004482 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 324831004483 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 324831004484 Helix-turn-helix domain; Region: HTH_28; pfam13518 324831004485 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 324831004486 Helix-turn-helix domain; Region: HTH_28; pfam13518 324831004487 Winged helix-turn helix; Region: HTH_29; pfam13551 324831004488 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 324831004489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831004490 active site 324831004491 motif I; other site 324831004492 motif II; other site 324831004493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831004494 putative lipid kinase; Reviewed; Region: PRK13337 324831004495 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 324831004496 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 324831004497 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 324831004498 GatB domain; Region: GatB_Yqey; smart00845 324831004499 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 324831004500 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 324831004501 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 324831004502 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 324831004503 putative dimer interface [polypeptide binding]; other site 324831004504 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 324831004505 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 324831004506 putative dimer interface [polypeptide binding]; other site 324831004507 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 324831004508 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 324831004509 nucleotide binding pocket [chemical binding]; other site 324831004510 K-X-D-G motif; other site 324831004511 catalytic site [active] 324831004512 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 324831004513 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 324831004514 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 324831004515 Dimer interface [polypeptide binding]; other site 324831004516 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 324831004517 Part of AAA domain; Region: AAA_19; pfam13245 324831004518 Family description; Region: UvrD_C_2; pfam13538 324831004519 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 324831004520 Predicted membrane protein [Function unknown]; Region: COG4684 324831004521 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 324831004522 hypothetical protein; Provisional; Region: PRK04351 324831004523 SprT homologues; Region: SprT; cl01182 324831004524 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 324831004525 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 324831004526 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 324831004527 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 324831004528 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 324831004529 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324831004530 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324831004531 non-specific DNA binding site [nucleotide binding]; other site 324831004532 salt bridge; other site 324831004533 sequence-specific DNA binding site [nucleotide binding]; other site 324831004534 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324831004535 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324831004536 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 324831004537 Walker A/P-loop; other site 324831004538 ATP binding site [chemical binding]; other site 324831004539 Q-loop/lid; other site 324831004540 ABC transporter signature motif; other site 324831004541 Walker B; other site 324831004542 D-loop; other site 324831004543 H-loop/switch region; other site 324831004544 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 324831004545 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 324831004546 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324831004547 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 324831004548 Soluble P-type ATPase [General function prediction only]; Region: COG4087 324831004549 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 324831004550 NAD synthetase; Reviewed; Region: nadE; PRK00768 324831004551 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 324831004552 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 324831004553 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 324831004554 active site 324831004555 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324831004556 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 324831004557 active site 324831004558 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324831004559 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 324831004560 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 324831004561 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 324831004562 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324831004563 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 324831004564 active site 324831004565 nucleotide binding site [chemical binding]; other site 324831004566 HIGH motif; other site 324831004567 KMSKS motif; other site 324831004568 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 324831004569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324831004570 DNA-binding site [nucleotide binding]; DNA binding site 324831004571 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 324831004572 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 324831004573 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 324831004574 active site residue [active] 324831004575 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 324831004576 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324831004577 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 324831004578 NAD binding site [chemical binding]; other site 324831004579 dimer interface [polypeptide binding]; other site 324831004580 substrate binding site [chemical binding]; other site 324831004581 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 324831004582 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 324831004583 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 324831004584 putative active site [active] 324831004585 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324831004586 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324831004587 Predicted membrane protein [Function unknown]; Region: COG4905 324831004588 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 324831004589 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 324831004590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324831004591 Coenzyme A binding pocket [chemical binding]; other site 324831004592 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 324831004593 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 324831004594 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324831004595 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324831004596 active site 324831004597 catalytic tetrad [active] 324831004598 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 324831004599 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324831004600 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 324831004601 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 324831004602 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 324831004603 NAD binding site [chemical binding]; other site 324831004604 homodimer interface [polypeptide binding]; other site 324831004605 active site 324831004606 substrate binding site [chemical binding]; other site 324831004607 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 324831004608 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324831004609 ATP binding site [chemical binding]; other site 324831004610 putative Mg++ binding site [ion binding]; other site 324831004611 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324831004612 nucleotide binding region [chemical binding]; other site 324831004613 ATP-binding site [chemical binding]; other site 324831004614 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 324831004615 AAA ATPase domain; Region: AAA_16; pfam13191 324831004616 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 324831004617 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 324831004618 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 324831004619 putative catalytic cysteine [active] 324831004620 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 324831004621 putative active site [active] 324831004622 metal binding site [ion binding]; metal-binding site 324831004623 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 324831004624 Sulfatase; Region: Sulfatase; pfam00884 324831004625 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 324831004626 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324831004627 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324831004628 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324831004629 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 324831004630 putative ADP-binding pocket [chemical binding]; other site 324831004631 seryl-tRNA synthetase; Provisional; Region: PRK05431 324831004632 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 324831004633 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 324831004634 dimer interface [polypeptide binding]; other site 324831004635 active site 324831004636 motif 1; other site 324831004637 motif 2; other site 324831004638 motif 3; other site 324831004639 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 324831004640 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 324831004641 Uncharacterized conserved protein [Function unknown]; Region: COG0398 324831004642 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 324831004643 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 324831004644 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 324831004645 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 324831004646 NAD(P) binding site [chemical binding]; other site 324831004647 catalytic residues [active] 324831004648 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 324831004649 Double zinc ribbon; Region: DZR; pfam12773 324831004650 Uncharacterized conserved protein [Function unknown]; Region: COG0398 324831004651 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 324831004652 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 324831004653 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324831004654 active site 324831004655 motif I; other site 324831004656 motif II; other site 324831004657 MMPL family; Region: MMPL; pfam03176 324831004658 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 324831004659 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 324831004660 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324831004661 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324831004662 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 324831004663 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324831004664 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 324831004665 nucleotide binding site [chemical binding]; other site 324831004666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324831004667 Coenzyme A binding pocket [chemical binding]; other site 324831004668 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324831004669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324831004670 Coenzyme A binding pocket [chemical binding]; other site 324831004671 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324831004672 MarR family; Region: MarR; pfam01047 324831004673 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 324831004674 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 324831004675 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324831004676 conserved hypothetical protein; Region: MG423; TIGR00649 324831004677 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 324831004678 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 324831004679 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324831004680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831004681 dimer interface [polypeptide binding]; other site 324831004682 conserved gate region; other site 324831004683 putative PBP binding loops; other site 324831004684 ABC-ATPase subunit interface; other site 324831004685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324831004686 dimer interface [polypeptide binding]; other site 324831004687 conserved gate region; other site 324831004688 putative PBP binding loops; other site 324831004689 ABC-ATPase subunit interface; other site 324831004690 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 324831004691 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 324831004692 Walker A/P-loop; other site 324831004693 ATP binding site [chemical binding]; other site 324831004694 Q-loop/lid; other site 324831004695 ABC transporter signature motif; other site 324831004696 Walker B; other site 324831004697 D-loop; other site 324831004698 H-loop/switch region; other site 324831004699 TOBE domain; Region: TOBE_2; pfam08402 324831004700 Peptidase family C69; Region: Peptidase_C69; pfam03577 324831004701 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 324831004702 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 324831004703 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 324831004704 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 324831004705 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 324831004706 active site 324831004707 catalytic site [active] 324831004708 substrate binding site [chemical binding]; other site 324831004709 Predicted membrane protein [Function unknown]; Region: COG2323 324831004710 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 324831004711 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 324831004712 peptidase T; Region: peptidase-T; TIGR01882 324831004713 metal binding site [ion binding]; metal-binding site 324831004714 dimer interface [polypeptide binding]; other site 324831004715 PAS domain; Region: PAS_10; pfam13596 324831004716 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 324831004717 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 324831004718 MucBP domain; Region: MucBP; pfam06458 324831004719 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 324831004720 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 324831004721 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 324831004722 PAS domain; Region: PAS_10; pfam13596 324831004723 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 324831004724 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 324831004725 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 324831004726 substrate binding site [chemical binding]; other site 324831004727 THF binding site; other site 324831004728 zinc-binding site [ion binding]; other site 324831004729 S-ribosylhomocysteinase; Provisional; Region: PRK02260 324831004730 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 324831004731 MucBP domain; Region: MucBP; pfam06458 324831004732 MucBP domain; Region: MucBP; pfam06458 324831004733 MucBP domain; Region: MucBP; pfam06458 324831004734 MucBP domain; Region: MucBP; pfam06458 324831004735 MucBP domain; Region: MucBP; pfam06458 324831004736 MucBP domain; Region: MucBP; pfam06458 324831004737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324831004738 Walker A/P-loop; other site 324831004739 ATP binding site [chemical binding]; other site 324831004740 Q-loop/lid; other site 324831004741 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324831004742 ABC transporter signature motif; other site 324831004743 Walker B; other site 324831004744 D-loop; other site 324831004745 H-loop/switch region; other site 324831004746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324831004747 AAA domain; Region: AAA_21; pfam13304 324831004748 Walker A/P-loop; other site 324831004749 ATP binding site [chemical binding]; other site 324831004750 Q-loop/lid; other site 324831004751 ABC transporter signature motif; other site 324831004752 Walker B; other site 324831004753 D-loop; other site 324831004754 H-loop/switch region; other site 324831004755 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 324831004756 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 324831004757 peptide binding site [polypeptide binding]; other site 324831004758 EamA-like transporter family; Region: EamA; pfam00892 324831004759 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 324831004760 EamA-like transporter family; Region: EamA; pfam00892 324831004761 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 324831004762 beta-galactosidase; Region: BGL; TIGR03356 324831004763 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 324831004764 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 324831004765 active site turn [active] 324831004766 phosphorylation site [posttranslational modification] 324831004767 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 324831004768 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 324831004769 HPr interaction site; other site 324831004770 glycerol kinase (GK) interaction site [polypeptide binding]; other site 324831004771 active site 324831004772 phosphorylation site [posttranslational modification] 324831004773 transcriptional antiterminator BglG; Provisional; Region: PRK09772 324831004774 CAT RNA binding domain; Region: CAT_RBD; smart01061 324831004775 PRD domain; Region: PRD; pfam00874 324831004776 PRD domain; Region: PRD; pfam00874 324831004777 Rib/alpha-like repeat; Region: Rib; pfam08428 324831004778 Rib/alpha-like repeat; Region: Rib; pfam08428 324831004779 Rib/alpha-like repeat; Region: Rib; pfam08428 324831004780 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 324831004781 elongation factor P; Validated; Region: PRK00529 324831004782 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 324831004783 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 324831004784 RNA binding site [nucleotide binding]; other site 324831004785 Elongation factor P, C-terminal; Region: Elong-fact-P_C; pfam09285 324831004786 RNA binding site [nucleotide binding]; other site 324831004787 pantothenate kinase; Provisional; Region: PRK05439 324831004788 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 324831004789 ATP-binding site [chemical binding]; other site 324831004790 CoA-binding site [chemical binding]; other site 324831004791 Mg2+-binding site [ion binding]; other site 324831004792 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 324831004793 active site 324831004794 catalytic triad [active] 324831004795 oxyanion hole [active] 324831004796 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 324831004797 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 324831004798 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 324831004799 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 324831004800 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 324831004801 putative active site [active] 324831004802 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 324831004803 putative active site [active] 324831004804 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 324831004805 Part of AAA domain; Region: AAA_19; pfam13245 324831004806 Family description; Region: UvrD_C_2; pfam13538 324831004807 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 324831004808 active site 324831004809 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 324831004810 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 324831004811 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 324831004812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 324831004813 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 324831004814 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 324831004815 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 324831004816 putative active site [active] 324831004817 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 324831004818 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 324831004819 putative active site cavity [active] 324831004820 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 324831004821 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 324831004822 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 324831004823 active site turn [active] 324831004824 phosphorylation site [posttranslational modification] 324831004825 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 324831004826 HPr interaction site; other site 324831004827 glycerol kinase (GK) interaction site [polypeptide binding]; other site 324831004828 active site 324831004829 phosphorylation site [posttranslational modification] 324831004830 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 324831004831 active site 324831004832 putative catalytic site [active] 324831004833 DNA binding site [nucleotide binding] 324831004834 putative phosphate binding site [ion binding]; other site 324831004835 metal binding site A [ion binding]; metal-binding site 324831004836 AP binding site [nucleotide binding]; other site 324831004837 metal binding site B [ion binding]; metal-binding site 324831004838 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324831004839 catalytic core [active] 324831004840 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324831004841 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324831004842 Walker A/P-loop; other site 324831004843 ATP binding site [chemical binding]; other site 324831004844 Q-loop/lid; other site 324831004845 ABC transporter signature motif; other site 324831004846 Walker B; other site 324831004847 D-loop; other site 324831004848 H-loop/switch region; other site 324831004849 Amino acid permease; Region: AA_permease_2; pfam13520 324831004850 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 324831004851 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 324831004852 HflX GTPase family; Region: HflX; cd01878 324831004853 G1 box; other site 324831004854 GTP/Mg2+ binding site [chemical binding]; other site 324831004855 Switch I region; other site 324831004856 G2 box; other site 324831004857 G3 box; other site 324831004858 Switch II region; other site 324831004859 G4 box; other site 324831004860 G5 box; other site 324831004861 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 324831004862 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 324831004863 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 324831004864 NlpC/P60 family; Region: NLPC_P60; pfam00877 324831004865 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 324831004866 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 324831004867 catalytic site [active] 324831004868 G-X2-G-X-G-K; other site 324831004869 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 324831004870 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 324831004871 dimer interface [polypeptide binding]; other site 324831004872 putative radical transfer pathway; other site 324831004873 diiron center [ion binding]; other site 324831004874 tyrosyl radical; other site 324831004875 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 324831004876 PemK-like protein; Region: PemK; pfam02452 324831004877 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 324831004878 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 324831004879 Uncharacterized conserved protein [Function unknown]; Region: COG2966 324831004880 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 324831004881 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324831004882 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324831004883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324831004884 Walker A/P-loop; other site 324831004885 ATP binding site [chemical binding]; other site 324831004886 Q-loop/lid; other site 324831004887 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324831004888 ABC transporter signature motif; other site 324831004889 Walker B; other site 324831004890 D-loop; other site 324831004891 ABC transporter; Region: ABC_tran_2; pfam12848 324831004892 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324831004893 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 324831004894 oligoendopeptidase F; Region: pepF; TIGR00181 324831004895 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 324831004896 active site 324831004897 Zn binding site [ion binding]; other site 324831004898 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 324831004899 L-lactate permease; Region: Lactate_perm; cl00701 324831004900 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 324831004901 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324831004902 ABC-ATPase subunit interface; other site 324831004903 dimer interface [polypeptide binding]; other site 324831004904 putative PBP binding regions; other site 324831004905 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324831004906 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 324831004907 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324831004908 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 324831004909 intersubunit interface [polypeptide binding]; other site 324831004910 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324831004911 dimerization interface [polypeptide binding]; other site 324831004912 putative DNA binding site [nucleotide binding]; other site 324831004913 putative Zn2+ binding site [ion binding]; other site 324831004914 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831004915 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324831004916 active site 324831004917 motif I; other site 324831004918 motif II; other site 324831004919 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 324831004920 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 324831004921 MucBP domain; Region: MucBP; pfam06458 324831004922 MucBP domain; Region: MucBP; pfam06458 324831004923 MucBP domain; Region: MucBP; pfam06458 324831004924 MucBP domain; Region: MucBP; pfam06458 324831004925 MucBP domain; Region: MucBP; pfam06458 324831004926 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 324831004927 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 324831004928 active site 324831004929 phosphorylation site [posttranslational modification] 324831004930 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 324831004931 active site 324831004932 P-loop; other site 324831004933 phosphorylation site [posttranslational modification] 324831004934 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 324831004935 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 324831004936 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 324831004937 putative substrate binding site [chemical binding]; other site 324831004938 putative ATP binding site [chemical binding]; other site 324831004939 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324831004940 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 324831004941 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 324831004942 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 324831004943 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 324831004944 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 324831004945 trimer interface [polypeptide binding]; other site 324831004946 active site 324831004947 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 324831004948 catalytic site [active] 324831004949 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 324831004950 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 324831004951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324831004952 Walker A/P-loop; other site 324831004953 ATP binding site [chemical binding]; other site 324831004954 Q-loop/lid; other site 324831004955 ABC transporter signature motif; other site 324831004956 Walker B; other site 324831004957 D-loop; other site 324831004958 H-loop/switch region; other site 324831004959 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 324831004960 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 324831004961 aspartate racemase; Region: asp_race; TIGR00035 324831004962 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 324831004963 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 324831004964 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324831004965 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324831004966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324831004967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324831004968 dimer interface [polypeptide binding]; other site 324831004969 phosphorylation site [posttranslational modification] 324831004970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324831004971 ATP binding site [chemical binding]; other site 324831004972 Mg2+ binding site [ion binding]; other site 324831004973 G-X-G motif; other site 324831004974 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324831004975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324831004976 active site 324831004977 phosphorylation site [posttranslational modification] 324831004978 intermolecular recognition site; other site 324831004979 dimerization interface [polypeptide binding]; other site 324831004980 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324831004981 DNA binding site [nucleotide binding] 324831004982 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324831004983 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324831004984 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 324831004985 Walker A/P-loop; other site 324831004986 ATP binding site [chemical binding]; other site 324831004987 Q-loop/lid; other site 324831004988 ABC transporter signature motif; other site 324831004989 Walker B; other site 324831004990 D-loop; other site 324831004991 H-loop/switch region; other site 324831004992 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324831004993 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324831004994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324831004995 Walker A/P-loop; other site 324831004996 ATP binding site [chemical binding]; other site 324831004997 Q-loop/lid; other site 324831004998 ABC transporter signature motif; other site 324831004999 Walker B; other site 324831005000 D-loop; other site 324831005001 H-loop/switch region; other site 324831005002 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 324831005003 GTP-binding protein YchF; Reviewed; Region: PRK09601 324831005004 YchF GTPase; Region: YchF; cd01900 324831005005 G1 box; other site 324831005006 GTP/Mg2+ binding site [chemical binding]; other site 324831005007 Switch I region; other site 324831005008 G2 box; other site 324831005009 Switch II region; other site 324831005010 G3 box; other site 324831005011 G4 box; other site 324831005012 G5 box; other site 324831005013 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 324831005014 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 324831005015 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 324831005016 ParB-like nuclease domain; Region: ParB; smart00470 324831005017 KorB domain; Region: KorB; pfam08535 324831005018 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 324831005019 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 324831005020 P-loop; other site 324831005021 Magnesium ion binding site [ion binding]; other site 324831005022 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 324831005023 Magnesium ion binding site [ion binding]; other site 324831005024 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 324831005025 ParB-like nuclease domain; Region: ParB; smart00470 324831005026 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 324831005027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324831005028 S-adenosylmethionine binding site [chemical binding]; other site 324831005029 Colicin V production protein; Region: Colicin_V; pfam02674 324831005030 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 324831005031 ApbE family; Region: ApbE; pfam02424 324831005032 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 324831005033 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 324831005034 Uncharacterized conserved protein [Function unknown]; Region: COG3589 324831005035 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 324831005036 Predicted flavoprotein [General function prediction only]; Region: COG0431 324831005037 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 324831005038 Predicted flavoprotein [General function prediction only]; Region: COG0431 324831005039 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 324831005040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324831005041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324831005042 WHG domain; Region: WHG; pfam13305 324831005043 Peptidase family C69; Region: Peptidase_C69; pfam03577 324831005044 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 324831005045 beta-galactosidase; Region: BGL; TIGR03356 324831005046 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 324831005047 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 324831005048 active site turn [active] 324831005049 phosphorylation site [posttranslational modification] 324831005050 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 324831005051 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 324831005052 HPr interaction site; other site 324831005053 glycerol kinase (GK) interaction site [polypeptide binding]; other site 324831005054 active site 324831005055 phosphorylation site [posttranslational modification] 324831005056 transcriptional antiterminator BglG; Provisional; Region: PRK09772 324831005057 CAT RNA binding domain; Region: CAT_RBD; smart01061 324831005058 PRD domain; Region: PRD; pfam00874 324831005059 PRD domain; Region: PRD; pfam00874 324831005060 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324831005061 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324831005062 Walker A/P-loop; other site 324831005063 ATP binding site [chemical binding]; other site 324831005064 Q-loop/lid; other site 324831005065 ABC transporter signature motif; other site 324831005066 Walker B; other site 324831005067 D-loop; other site 324831005068 H-loop/switch region; other site 324831005069 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 324831005070 FtsX-like permease family; Region: FtsX; pfam02687 324831005071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324831005072 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324831005073 catalytic core [active] 324831005074 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324831005075 catalytic core [active] 324831005076 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324831005077 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 324831005078 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 324831005079 catalytic site [active] 324831005080 Protein of unknown function (DUF975); Region: DUF975; pfam06161 324831005081 hypothetical protein; Validated; Region: PRK02101 324831005082 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 324831005083 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 324831005084 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 324831005085 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 324831005086 putative active site [active] 324831005087 catalytic site [active] 324831005088 putative metal binding site [ion binding]; other site 324831005089 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 324831005090 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 324831005091 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 324831005092 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 324831005093 putative active site [active] 324831005094 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 324831005095 nucleotide binding site/active site [active] 324831005096 HIT family signature motif; other site 324831005097 catalytic residue [active] 324831005098 drug efflux system protein MdtG; Provisional; Region: PRK09874 324831005099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831005100 putative substrate translocation pore; other site 324831005101 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 324831005102 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 324831005103 catalytic triad [active] 324831005104 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324831005105 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324831005106 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 324831005107 Walker A/P-loop; other site 324831005108 ATP binding site [chemical binding]; other site 324831005109 Q-loop/lid; other site 324831005110 ABC transporter signature motif; other site 324831005111 Walker B; other site 324831005112 D-loop; other site 324831005113 H-loop/switch region; other site 324831005114 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 324831005115 putative ADP-ribose binding site [chemical binding]; other site 324831005116 putative active site [active] 324831005117 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 324831005118 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 324831005119 active site turn [active] 324831005120 phosphorylation site [posttranslational modification] 324831005121 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 324831005122 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 324831005123 HPr interaction site; other site 324831005124 glycerol kinase (GK) interaction site [polypeptide binding]; other site 324831005125 active site 324831005126 phosphorylation site [posttranslational modification] 324831005127 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 324831005128 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 324831005129 substrate binding [chemical binding]; other site 324831005130 active site 324831005131 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 324831005132 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324831005133 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324831005134 DNA binding site [nucleotide binding] 324831005135 domain linker motif; other site 324831005136 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 324831005137 dimerization interface [polypeptide binding]; other site 324831005138 ligand binding site [chemical binding]; other site 324831005139 sodium binding site [ion binding]; other site 324831005140 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 324831005141 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 324831005142 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 324831005143 substrate binding site [chemical binding]; other site 324831005144 dimer interface [polypeptide binding]; other site 324831005145 ATP binding site [chemical binding]; other site 324831005146 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 324831005147 catalytic triad [active] 324831005148 amino acid transporter; Region: 2A0306; TIGR00909 324831005149 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 324831005150 EamA-like transporter family; Region: EamA; pfam00892 324831005151 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 324831005152 EamA-like transporter family; Region: EamA; pfam00892 324831005153 asparagine synthetase A; Reviewed; Region: PRK06462 324831005154 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 324831005155 dimer interface [polypeptide binding]; other site 324831005156 active site 324831005157 CAAX protease self-immunity; Region: Abi; pfam02517 324831005158 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 324831005159 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 324831005160 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 324831005161 catalytic triad [active] 324831005162 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 324831005163 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 324831005164 Domain of unknown function (DUF956); Region: DUF956; pfam06115 324831005165 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 324831005166 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 324831005167 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 324831005168 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 324831005169 active pocket/dimerization site; other site 324831005170 active site 324831005171 phosphorylation site [posttranslational modification] 324831005172 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 324831005173 active site 324831005174 phosphorylation site [posttranslational modification] 324831005175 amino acid transporter; Region: 2A0306; TIGR00909 324831005176 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 324831005177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324831005178 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 324831005179 Walker A motif; other site 324831005180 ATP binding site [chemical binding]; other site 324831005181 Walker B motif; other site 324831005182 arginine finger; other site 324831005183 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324831005184 Walker A motif; other site 324831005185 ATP binding site [chemical binding]; other site 324831005186 Walker B motif; other site 324831005187 arginine finger; other site 324831005188 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 324831005189 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 324831005190 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 324831005191 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 324831005192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831005193 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324831005194 putative substrate translocation pore; other site 324831005195 Beta-lactamase; Region: Beta-lactamase; pfam00144 324831005196 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 324831005197 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 324831005198 DltD N-terminal region; Region: DltD_N; pfam04915 324831005199 DltD central region; Region: DltD_M; pfam04918 324831005200 DltD C-terminal region; Region: DltD_C; pfam04914 324831005201 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 324831005202 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 324831005203 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 324831005204 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 324831005205 acyl-activating enzyme (AAE) consensus motif; other site 324831005206 AMP binding site [chemical binding]; other site 324831005207 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 324831005208 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 324831005209 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324831005210 Soluble P-type ATPase [General function prediction only]; Region: COG4087 324831005211 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 324831005212 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 324831005213 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324831005214 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324831005215 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 324831005216 Walker A/P-loop; other site 324831005217 ATP binding site [chemical binding]; other site 324831005218 Q-loop/lid; other site 324831005219 ABC transporter signature motif; other site 324831005220 Walker B; other site 324831005221 D-loop; other site 324831005222 H-loop/switch region; other site 324831005223 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324831005224 non-specific DNA binding site [nucleotide binding]; other site 324831005225 salt bridge; other site 324831005226 sequence-specific DNA binding site [nucleotide binding]; other site 324831005227 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 324831005228 putative substrate binding pocket [chemical binding]; other site 324831005229 AC domain interface; other site 324831005230 catalytic triad [active] 324831005231 AB domain interface; other site 324831005232 interchain disulfide; other site 324831005233 Predicted membrane protein [Function unknown]; Region: COG3817 324831005234 Protein of unknown function (DUF979); Region: DUF979; pfam06166 324831005235 Protein of unknown function (DUF969); Region: DUF969; pfam06149 324831005236 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 324831005237 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 324831005238 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 324831005239 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 324831005240 CAAX protease self-immunity; Region: Abi; pfam02517 324831005241 Uncharacterized conserved protein [Function unknown]; Region: COG1434 324831005242 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 324831005243 putative active site [active] 324831005244 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324831005245 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324831005246 Walker A/P-loop; other site 324831005247 ATP binding site [chemical binding]; other site 324831005248 Q-loop/lid; other site 324831005249 ABC transporter signature motif; other site 324831005250 Walker B; other site 324831005251 D-loop; other site 324831005252 H-loop/switch region; other site 324831005253 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 324831005254 FtsX-like permease family; Region: FtsX; pfam02687 324831005255 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 324831005256 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 324831005257 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 324831005258 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 324831005259 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324831005260 Walker A/P-loop; other site 324831005261 ATP binding site [chemical binding]; other site 324831005262 Q-loop/lid; other site 324831005263 ABC transporter signature motif; other site 324831005264 Walker B; other site 324831005265 D-loop; other site 324831005266 H-loop/switch region; other site 324831005267 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 324831005268 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 324831005269 Walker A/P-loop; other site 324831005270 ATP binding site [chemical binding]; other site 324831005271 Q-loop/lid; other site 324831005272 ABC transporter signature motif; other site 324831005273 Walker B; other site 324831005274 D-loop; other site 324831005275 H-loop/switch region; other site 324831005276 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 324831005277 UbiA prenyltransferase family; Region: UbiA; pfam01040 324831005278 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 324831005279 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324831005280 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324831005281 substrate binding pocket [chemical binding]; other site 324831005282 membrane-bound complex binding site; other site 324831005283 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 324831005284 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 324831005285 ligand binding site [chemical binding]; other site 324831005286 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 324831005287 Beta-lactamase; Region: Beta-lactamase; pfam00144 324831005288 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 324831005289 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 324831005290 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 324831005291 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 324831005292 Uncharacterized conserved protein [Function unknown]; Region: COG3589 324831005293 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 324831005294 Putative esterase; Region: Esterase; pfam00756 324831005295 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 324831005296 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 324831005297 active site 324831005298 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 324831005299 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 324831005300 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 324831005301 putative active site [active] 324831005302 hypothetical protein; Provisional; Region: PRK10621 324831005303 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 324831005304 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324831005305 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324831005306 active site 324831005307 catalytic tetrad [active] 324831005308 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 324831005309 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 324831005310 active site 324831005311 trimer interface [polypeptide binding]; other site 324831005312 allosteric site; other site 324831005313 active site lid [active] 324831005314 hexamer (dimer of trimers) interface [polypeptide binding]; other site 324831005315 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 324831005316 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 324831005317 Substrate-binding site [chemical binding]; other site 324831005318 Substrate specificity [chemical binding]; other site 324831005319 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 324831005320 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 324831005321 Substrate-binding site [chemical binding]; other site 324831005322 Substrate specificity [chemical binding]; other site 324831005323 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 324831005324 teramer interface [polypeptide binding]; other site 324831005325 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 324831005326 active site 324831005327 FMN binding site [chemical binding]; other site 324831005328 catalytic residues [active] 324831005329 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 324831005330 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 324831005331 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324831005332 DNA binding residues [nucleotide binding] 324831005333 dimer interface [polypeptide binding]; other site 324831005334 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 324831005335 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 324831005336 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 324831005337 metal binding site [ion binding]; metal-binding site 324831005338 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 324831005339 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 324831005340 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 324831005341 active site 324831005342 catalytic residues [active] 324831005343 metal binding site [ion binding]; metal-binding site 324831005344 hypothetical protein; Validated; Region: PRK00068 324831005345 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 324831005346 Penicillinase repressor; Region: Pencillinase_R; pfam03965 324831005347 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 324831005348 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 324831005349 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 324831005350 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324831005351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324831005352 motif II; other site 324831005353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324831005354 non-specific DNA binding site [nucleotide binding]; other site 324831005355 salt bridge; other site 324831005356 sequence-specific DNA binding site [nucleotide binding]; other site 324831005357 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 324831005358 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 324831005359 active site 324831005360 Zn binding site [ion binding]; other site 324831005361 Amino acid permease; Region: AA_permease_2; pfam13520 324831005362 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 324831005363 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 324831005364 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324831005365 catalytic residue [active] 324831005366 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 324831005367 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 324831005368 Aluminium resistance protein; Region: Alum_res; pfam06838 324831005369 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324831005370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324831005371 Coenzyme A binding pocket [chemical binding]; other site 324831005372 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 324831005373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324831005374 putative substrate translocation pore; other site 324831005375 MutS domain III; Region: MutS_III; pfam05192 324831005376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324831005377 Walker A/P-loop; other site 324831005378 ATP binding site [chemical binding]; other site 324831005379 Q-loop/lid; other site 324831005380 ABC transporter signature motif; other site 324831005381 Walker B; other site 324831005382 D-loop; other site 324831005383 H-loop/switch region; other site 324831005384 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324831005385 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324831005386 ligand binding site [chemical binding]; other site 324831005387 flexible hinge region; other site 324831005388 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 324831005389 putative switch regulator; other site 324831005390 non-specific DNA interactions [nucleotide binding]; other site 324831005391 DNA binding site [nucleotide binding] 324831005392 sequence specific DNA binding site [nucleotide binding]; other site 324831005393 putative cAMP binding site [chemical binding]; other site 324831005394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324831005395 non-specific DNA binding site [nucleotide binding]; other site 324831005396 salt bridge; other site 324831005397 sequence-specific DNA binding site [nucleotide binding]; other site 324831005398 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 324831005399 H+ Antiporter protein; Region: 2A0121; TIGR00900 324831005400 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 324831005401 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 324831005402 Cl- selectivity filter; other site 324831005403 Cl- binding residues [ion binding]; other site 324831005404 pore gating glutamate residue; other site 324831005405 dimer interface [polypeptide binding]; other site 324831005406 H+/Cl- coupling transport residue; other site 324831005407 TrkA-C domain; Region: TrkA_C; pfam02080 324831005408 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 324831005409 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 324831005410 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 324831005411 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 324831005412 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 324831005413 PYR/PP interface [polypeptide binding]; other site 324831005414 dimer interface [polypeptide binding]; other site 324831005415 tetramer interface [polypeptide binding]; other site 324831005416 TPP binding site [chemical binding]; other site 324831005417 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 324831005418 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 324831005419 TPP-binding site [chemical binding]; other site 324831005420 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 324831005421 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 324831005422 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 324831005423 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 324831005424 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 324831005425 trmE is a tRNA modification GTPase; Region: trmE; cd04164 324831005426 G1 box; other site 324831005427 GTP/Mg2+ binding site [chemical binding]; other site 324831005428 Switch I region; other site 324831005429 G2 box; other site 324831005430 Switch II region; other site 324831005431 G3 box; other site 324831005432 G4 box; other site 324831005433 G5 box; other site 324831005434 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 324831005435 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 324831005436 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 324831005437 ribonuclease P; Reviewed; Region: rnpA; PRK00499 324831005438 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399