-- dump date 20140619_123523 -- class Genbank::misc_feature -- table misc_feature_note -- id note 326425000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 326425000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 326425000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326425000004 Walker A motif; other site 326425000005 ATP binding site [chemical binding]; other site 326425000006 Walker B motif; other site 326425000007 arginine finger; other site 326425000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 326425000009 DnaA box-binding interface [nucleotide binding]; other site 326425000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 326425000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 326425000012 putative DNA binding surface [nucleotide binding]; other site 326425000013 dimer interface [polypeptide binding]; other site 326425000014 beta-clamp/clamp loader binding surface; other site 326425000015 beta-clamp/translesion DNA polymerase binding surface; other site 326425000016 S4 domain; Region: S4_2; pfam13275 326425000017 recombination protein F; Reviewed; Region: recF; PRK00064 326425000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 326425000019 Walker A/P-loop; other site 326425000020 ATP binding site [chemical binding]; other site 326425000021 Q-loop/lid; other site 326425000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326425000023 ABC transporter signature motif; other site 326425000024 Walker B; other site 326425000025 D-loop; other site 326425000026 H-loop/switch region; other site 326425000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 326425000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326425000029 Mg2+ binding site [ion binding]; other site 326425000030 G-X-G motif; other site 326425000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 326425000032 anchoring element; other site 326425000033 dimer interface [polypeptide binding]; other site 326425000034 ATP binding site [chemical binding]; other site 326425000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 326425000036 active site 326425000037 putative metal-binding site [ion binding]; other site 326425000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 326425000039 DNA gyrase subunit A; Validated; Region: PRK05560 326425000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 326425000041 CAP-like domain; other site 326425000042 active site 326425000043 primary dimer interface [polypeptide binding]; other site 326425000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326425000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326425000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326425000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326425000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326425000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326425000050 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 326425000051 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 326425000052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 326425000053 dimer interface [polypeptide binding]; other site 326425000054 ssDNA binding site [nucleotide binding]; other site 326425000055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 326425000056 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 326425000057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326425000058 Q-loop/lid; other site 326425000059 ABC transporter signature motif; other site 326425000060 Walker B; other site 326425000061 D-loop; other site 326425000062 H-loop/switch region; other site 326425000063 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326425000064 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326425000065 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 326425000066 active site 326425000067 zinc binding site [ion binding]; other site 326425000068 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 326425000069 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326425000070 active site 326425000071 ATP binding site [chemical binding]; other site 326425000072 substrate binding site [chemical binding]; other site 326425000073 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 326425000074 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 326425000075 DHH family; Region: DHH; pfam01368 326425000076 DHHA1 domain; Region: DHHA1; pfam02272 326425000077 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 326425000078 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 326425000079 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 326425000080 replicative DNA helicase; Region: DnaB; TIGR00665 326425000081 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 326425000082 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 326425000083 Walker A motif; other site 326425000084 ATP binding site [chemical binding]; other site 326425000085 Walker B motif; other site 326425000086 DNA binding loops [nucleotide binding] 326425000087 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 326425000088 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326425000089 substrate binding pocket [chemical binding]; other site 326425000090 membrane-bound complex binding site; other site 326425000091 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 326425000092 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 326425000093 nucleotide binding site [chemical binding]; other site 326425000094 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 326425000095 MgtC family; Region: MgtC; pfam02308 326425000096 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326425000097 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326425000098 non-specific DNA binding site [nucleotide binding]; other site 326425000099 salt bridge; other site 326425000100 sequence-specific DNA binding site [nucleotide binding]; other site 326425000101 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326425000102 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 326425000103 Replication initiation factor; Region: Rep_trans; pfam02486 326425000104 Helix-turn-helix domain; Region: HTH_17; pfam12728 326425000105 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326425000106 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 326425000107 active site 326425000108 catalytic residues [active] 326425000109 DNA binding site [nucleotide binding] 326425000110 Int/Topo IB signature motif; other site 326425000111 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326425000112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326425000113 non-specific DNA binding site [nucleotide binding]; other site 326425000114 salt bridge; other site 326425000115 sequence-specific DNA binding site [nucleotide binding]; other site 326425000116 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 326425000117 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326425000118 Walker A/P-loop; other site 326425000119 ATP binding site [chemical binding]; other site 326425000120 Q-loop/lid; other site 326425000121 ABC transporter signature motif; other site 326425000122 Walker B; other site 326425000123 D-loop; other site 326425000124 H-loop/switch region; other site 326425000125 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 326425000126 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 326425000127 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326425000128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326425000129 Restriction endonuclease; Region: Mrr_cat; pfam04471 326425000130 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 326425000131 Predicted membrane protein [Function unknown]; Region: COG4905 326425000132 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 326425000133 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 326425000134 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 326425000135 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 326425000136 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 326425000137 Domain of unknown function DUF20; Region: UPF0118; pfam01594 326425000138 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 326425000139 catalytic triad [active] 326425000140 oxyanion hole [active] 326425000141 active site 326425000142 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 326425000143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326425000144 Walker A/P-loop; other site 326425000145 ATP binding site [chemical binding]; other site 326425000146 Q-loop/lid; other site 326425000147 ABC transporter signature motif; other site 326425000148 Walker B; other site 326425000149 D-loop; other site 326425000150 H-loop/switch region; other site 326425000151 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 326425000152 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 326425000153 TM-ABC transporter signature motif; other site 326425000154 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 326425000155 zinc binding site [ion binding]; other site 326425000156 putative ligand binding site [chemical binding]; other site 326425000157 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326425000158 motif II; other site 326425000159 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 326425000160 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326425000161 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326425000162 active site 326425000163 catalytic tetrad [active] 326425000164 D-lactate dehydrogenase; Validated; Region: PRK08605 326425000165 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 326425000166 homodimer interface [polypeptide binding]; other site 326425000167 ligand binding site [chemical binding]; other site 326425000168 NAD binding site [chemical binding]; other site 326425000169 catalytic site [active] 326425000170 Fructosamine kinase; Region: Fructosamin_kin; cl17579 326425000171 Phosphotransferase enzyme family; Region: APH; pfam01636 326425000172 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 326425000173 active site 326425000174 putative catalytic site [active] 326425000175 DNA binding site [nucleotide binding] 326425000176 putative phosphate binding site [ion binding]; other site 326425000177 metal binding site A [ion binding]; metal-binding site 326425000178 AP binding site [nucleotide binding]; other site 326425000179 metal binding site B [ion binding]; metal-binding site 326425000180 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 326425000181 PLD-like domain; Region: PLDc_2; pfam13091 326425000182 putative homodimer interface [polypeptide binding]; other site 326425000183 putative active site [active] 326425000184 catalytic site [active] 326425000185 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 326425000186 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326425000187 ATP binding site [chemical binding]; other site 326425000188 putative Mg++ binding site [ion binding]; other site 326425000189 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326425000190 nucleotide binding region [chemical binding]; other site 326425000191 ATP-binding site [chemical binding]; other site 326425000192 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 326425000193 Beta-lactamase; Region: Beta-lactamase; pfam00144 326425000194 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 326425000195 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 326425000196 active site 326425000197 catalytic residues [active] 326425000198 metal binding site [ion binding]; metal-binding site 326425000199 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326425000200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326425000201 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 326425000202 dimerization interface [polypeptide binding]; other site 326425000203 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 326425000204 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 326425000205 putative acyl-acceptor binding pocket; other site 326425000206 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 326425000207 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 326425000208 Ligand binding site; other site 326425000209 metal-binding site 326425000210 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 326425000211 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 326425000212 Ligand binding site; other site 326425000213 metal-binding site 326425000214 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326425000215 active site 326425000216 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 326425000217 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 326425000218 putative acyl-acceptor binding pocket; other site 326425000219 Bacterial surface layer protein; Region: SLAP; pfam03217 326425000220 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326425000221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326425000222 active site 326425000223 phosphorylation site [posttranslational modification] 326425000224 intermolecular recognition site; other site 326425000225 dimerization interface [polypeptide binding]; other site 326425000226 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326425000227 DNA binding site [nucleotide binding] 326425000228 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 326425000229 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326425000230 dimerization interface [polypeptide binding]; other site 326425000231 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326425000232 putative active site [active] 326425000233 heme pocket [chemical binding]; other site 326425000234 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326425000235 dimer interface [polypeptide binding]; other site 326425000236 phosphorylation site [posttranslational modification] 326425000237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326425000238 ATP binding site [chemical binding]; other site 326425000239 Mg2+ binding site [ion binding]; other site 326425000240 G-X-G motif; other site 326425000241 YycH protein; Region: YycH; pfam07435 326425000242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 326425000243 YycH protein; Region: YycI; pfam09648 326425000244 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 326425000245 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 326425000246 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 326425000247 protein binding site [polypeptide binding]; other site 326425000248 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 326425000249 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326425000250 non-specific DNA binding site [nucleotide binding]; other site 326425000251 salt bridge; other site 326425000252 sequence-specific DNA binding site [nucleotide binding]; other site 326425000253 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 326425000254 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 326425000255 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326425000256 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326425000257 Walker A/P-loop; other site 326425000258 ATP binding site [chemical binding]; other site 326425000259 Q-loop/lid; other site 326425000260 ABC transporter signature motif; other site 326425000261 Walker B; other site 326425000262 D-loop; other site 326425000263 H-loop/switch region; other site 326425000264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326425000265 Walker A/P-loop; other site 326425000266 ATP binding site [chemical binding]; other site 326425000267 ABC transporter; Region: ABC_tran; pfam00005 326425000268 Q-loop/lid; other site 326425000269 ABC transporter signature motif; other site 326425000270 Walker B; other site 326425000271 D-loop; other site 326425000272 H-loop/switch region; other site 326425000273 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 326425000274 Helix-turn-helix domain; Region: HTH_18; pfam12833 326425000275 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326425000276 heat shock protein HtpX; Provisional; Region: PRK04897 326425000277 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 326425000278 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 326425000279 transmembrane helices; other site 326425000280 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 326425000281 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326425000282 Zn2+ binding site [ion binding]; other site 326425000283 Mg2+ binding site [ion binding]; other site 326425000284 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 326425000285 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326425000286 active site 326425000287 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326425000288 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 326425000289 Walker A/P-loop; other site 326425000290 ATP binding site [chemical binding]; other site 326425000291 Q-loop/lid; other site 326425000292 ABC transporter signature motif; other site 326425000293 Walker B; other site 326425000294 D-loop; other site 326425000295 H-loop/switch region; other site 326425000296 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326425000297 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326425000298 substrate binding pocket [chemical binding]; other site 326425000299 membrane-bound complex binding site; other site 326425000300 hinge residues; other site 326425000301 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 326425000302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425000303 dimer interface [polypeptide binding]; other site 326425000304 conserved gate region; other site 326425000305 putative PBP binding loops; other site 326425000306 ABC-ATPase subunit interface; other site 326425000307 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 326425000308 active site 326425000309 DNA binding site [nucleotide binding] 326425000310 Protein of unknown function, DUF488; Region: DUF488; cl01246 326425000311 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 326425000312 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 326425000313 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 326425000314 DNA binding site [nucleotide binding] 326425000315 active site 326425000316 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 326425000317 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 326425000318 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 326425000319 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 326425000320 putative active site [active] 326425000321 catalytic site [active] 326425000322 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 326425000323 putative active site [active] 326425000324 catalytic site [active] 326425000325 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 326425000326 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 326425000327 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 326425000328 RNA/DNA hybrid binding site [nucleotide binding]; other site 326425000329 active site 326425000330 Predicted secreted protein [Function unknown]; Region: COG4086 326425000331 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 326425000332 putative glycosyl transferase; Provisional; Region: PRK10073 326425000333 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326425000334 active site 326425000335 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 326425000336 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326425000337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326425000338 NADH(P)-binding; Region: NAD_binding_10; pfam13460 326425000339 NAD(P) binding site [chemical binding]; other site 326425000340 active site 326425000341 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 326425000342 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 326425000343 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326425000344 active site 326425000345 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326425000346 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326425000347 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326425000348 substrate binding pocket [chemical binding]; other site 326425000349 membrane-bound complex binding site; other site 326425000350 hinge residues; other site 326425000351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425000352 dimer interface [polypeptide binding]; other site 326425000353 conserved gate region; other site 326425000354 putative PBP binding loops; other site 326425000355 ABC-ATPase subunit interface; other site 326425000356 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326425000357 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 326425000358 Walker A/P-loop; other site 326425000359 ATP binding site [chemical binding]; other site 326425000360 Q-loop/lid; other site 326425000361 ABC transporter signature motif; other site 326425000362 Walker B; other site 326425000363 D-loop; other site 326425000364 H-loop/switch region; other site 326425000365 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 326425000366 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 326425000367 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 326425000368 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326425000369 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 326425000370 DNA binding residues [nucleotide binding] 326425000371 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 326425000372 YibE/F-like protein; Region: YibE_F; pfam07907 326425000373 YibE/F-like protein; Region: YibE_F; pfam07907 326425000374 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 326425000375 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 326425000376 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 326425000377 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 326425000378 active site 326425000379 catalytic site [active] 326425000380 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 326425000381 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 326425000382 Interdomain contacts; other site 326425000383 Cytokine receptor motif; other site 326425000384 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 326425000385 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 326425000386 active site 326425000387 phosphorylation site [posttranslational modification] 326425000388 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 326425000389 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 326425000390 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 326425000391 Ligand Binding Site [chemical binding]; other site 326425000392 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 326425000393 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 326425000394 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326425000395 membrane-bound complex binding site; other site 326425000396 hinge residues; other site 326425000397 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 326425000398 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 326425000399 Walker A/P-loop; other site 326425000400 ATP binding site [chemical binding]; other site 326425000401 Q-loop/lid; other site 326425000402 ABC transporter signature motif; other site 326425000403 Walker B; other site 326425000404 D-loop; other site 326425000405 H-loop/switch region; other site 326425000406 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 326425000407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425000408 dimer interface [polypeptide binding]; other site 326425000409 conserved gate region; other site 326425000410 putative PBP binding loops; other site 326425000411 ABC-ATPase subunit interface; other site 326425000412 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 326425000413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425000414 dimer interface [polypeptide binding]; other site 326425000415 conserved gate region; other site 326425000416 putative PBP binding loops; other site 326425000417 ABC-ATPase subunit interface; other site 326425000418 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 326425000419 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 326425000420 active site 326425000421 metal binding site [ion binding]; metal-binding site 326425000422 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 326425000423 active site 326425000424 dimer interface [polypeptide binding]; other site 326425000425 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 326425000426 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 326425000427 Ligand Binding Site [chemical binding]; other site 326425000428 Molecular Tunnel; other site 326425000429 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 326425000430 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 326425000431 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 326425000432 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 326425000433 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 326425000434 ATP cone domain; Region: ATP-cone; pfam03477 326425000435 Class III ribonucleotide reductase; Region: RNR_III; cd01675 326425000436 effector binding site; other site 326425000437 active site 326425000438 Zn binding site [ion binding]; other site 326425000439 glycine loop; other site 326425000440 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 326425000441 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 326425000442 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 326425000443 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 326425000444 Uncharacterized conserved protein [Function unknown]; Region: COG2461 326425000445 Family of unknown function (DUF438); Region: DUF438; pfam04282 326425000446 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 326425000447 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326425000448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326425000449 putative substrate translocation pore; other site 326425000450 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 326425000451 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 326425000452 active site 326425000453 Zn binding site [ion binding]; other site 326425000454 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 326425000455 Bacterial surface layer protein; Region: SLAP; pfam03217 326425000456 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 326425000457 Bacterial surface layer protein; Region: SLAP; pfam03217 326425000458 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 326425000459 amidase catalytic site [active] 326425000460 Zn binding residues [ion binding]; other site 326425000461 substrate binding site [chemical binding]; other site 326425000462 Bacterial surface layer protein; Region: SLAP; pfam03217 326425000463 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 326425000464 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 326425000465 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 326425000466 TrkA-N domain; Region: TrkA_N; pfam02254 326425000467 TrkA-C domain; Region: TrkA_C; pfam02080 326425000468 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 326425000469 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 326425000470 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 326425000471 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 326425000472 PQQ-like domain; Region: PQQ_2; pfam13360 326425000473 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 326425000474 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 326425000475 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 326425000476 acyl-activating enzyme (AAE) consensus motif; other site 326425000477 AMP binding site [chemical binding]; other site 326425000478 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 326425000479 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 326425000480 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 326425000481 DltD N-terminal region; Region: DltD_N; pfam04915 326425000482 DltD central region; Region: DltD_M; pfam04918 326425000483 DltD C-terminal region; Region: DltD_C; pfam04914 326425000484 Beta-lactamase; Region: Beta-lactamase; pfam00144 326425000485 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 326425000486 CAAX protease self-immunity; Region: Abi; pfam02517 326425000487 Protein of unknown function (DUF975); Region: DUF975; cl10504 326425000488 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 326425000489 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 326425000490 active site 326425000491 stage V sporulation protein B; Region: spore_V_B; TIGR02900 326425000492 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 326425000493 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326425000494 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326425000495 Walker A/P-loop; other site 326425000496 ATP binding site [chemical binding]; other site 326425000497 Q-loop/lid; other site 326425000498 ABC transporter signature motif; other site 326425000499 Walker B; other site 326425000500 D-loop; other site 326425000501 H-loop/switch region; other site 326425000502 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 326425000503 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 326425000504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326425000505 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 326425000506 Walker A motif; other site 326425000507 ATP binding site [chemical binding]; other site 326425000508 Walker B motif; other site 326425000509 arginine finger; other site 326425000510 UvrB/uvrC motif; Region: UVR; pfam02151 326425000511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326425000512 Walker A motif; other site 326425000513 ATP binding site [chemical binding]; other site 326425000514 Walker B motif; other site 326425000515 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 326425000516 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 326425000517 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 326425000518 Catalytic site [active] 326425000519 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 326425000520 cAMP-dependent protein kinase catalytic subunit; Provisional; Region: PTZ00426 326425000521 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 326425000522 putative transport protein YifK; Provisional; Region: PRK10746 326425000523 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 326425000524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326425000525 Walker A/P-loop; other site 326425000526 ATP binding site [chemical binding]; other site 326425000527 Q-loop/lid; other site 326425000528 ABC transporter signature motif; other site 326425000529 Walker B; other site 326425000530 D-loop; other site 326425000531 H-loop/switch region; other site 326425000532 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 326425000533 dimer interface [polypeptide binding]; other site 326425000534 active site 326425000535 Uncharacterized conserved protein [Function unknown]; Region: COG3589 326425000536 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 326425000537 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 326425000538 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 326425000539 active site 326425000540 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 326425000541 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 326425000542 GDP-binding site [chemical binding]; other site 326425000543 ACT binding site; other site 326425000544 IMP binding site; other site 326425000545 adenylosuccinate lyase; Provisional; Region: PRK07492 326425000546 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 326425000547 tetramer interface [polypeptide binding]; other site 326425000548 active site 326425000549 Uncharacterized conserved protein [Function unknown]; Region: COG1434 326425000550 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 326425000551 putative active site [active] 326425000552 EamA-like transporter family; Region: EamA; cl17759 326425000553 EamA-like transporter family; Region: EamA; pfam00892 326425000554 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 326425000555 NlpC/P60 family; Region: NLPC_P60; cl17555 326425000556 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 326425000557 catalytic triad [active] 326425000558 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 326425000559 dimer interface [polypeptide binding]; other site 326425000560 substrate binding site [chemical binding]; other site 326425000561 ATP binding site [chemical binding]; other site 326425000562 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 326425000563 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 326425000564 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326425000565 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326425000566 DNA binding site [nucleotide binding] 326425000567 domain linker motif; other site 326425000568 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326425000569 ligand binding site [chemical binding]; other site 326425000570 dimerization interface [polypeptide binding]; other site 326425000571 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 326425000572 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 326425000573 Ca binding site [ion binding]; other site 326425000574 active site 326425000575 catalytic site [active] 326425000576 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 326425000577 homodimer interface [polypeptide binding]; other site 326425000578 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 326425000579 active site 326425000580 homodimer interface [polypeptide binding]; other site 326425000581 catalytic site [active] 326425000582 maltose phosphorylase; Provisional; Region: PRK13807 326425000583 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 326425000584 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 326425000585 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 326425000586 beta-phosphoglucomutase; Region: bPGM; TIGR01990 326425000587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326425000588 motif II; other site 326425000589 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 326425000590 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 326425000591 Walker A/P-loop; other site 326425000592 ATP binding site [chemical binding]; other site 326425000593 Q-loop/lid; other site 326425000594 ABC transporter signature motif; other site 326425000595 Walker B; other site 326425000596 D-loop; other site 326425000597 H-loop/switch region; other site 326425000598 TOBE domain; Region: TOBE_2; pfam08402 326425000599 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326425000600 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 326425000601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425000602 dimer interface [polypeptide binding]; other site 326425000603 conserved gate region; other site 326425000604 ABC-ATPase subunit interface; other site 326425000605 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326425000606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425000607 dimer interface [polypeptide binding]; other site 326425000608 conserved gate region; other site 326425000609 putative PBP binding loops; other site 326425000610 ABC-ATPase subunit interface; other site 326425000611 legume lectins; Region: lectin_L-type; cl14058 326425000612 homotetramer interaction site [polypeptide binding]; other site 326425000613 carbohydrate binding site [chemical binding]; other site 326425000614 metal binding site [ion binding]; metal-binding site 326425000615 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 326425000616 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 326425000617 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 326425000618 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 326425000619 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 326425000620 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 326425000621 Asp23 family; Region: Asp23; pfam03780 326425000622 Cobalt transport protein; Region: CbiQ; cl00463 326425000623 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326425000624 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326425000625 Walker A/P-loop; other site 326425000626 ATP binding site [chemical binding]; other site 326425000627 Q-loop/lid; other site 326425000628 ABC transporter signature motif; other site 326425000629 Walker B; other site 326425000630 D-loop; other site 326425000631 H-loop/switch region; other site 326425000632 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326425000633 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326425000634 Walker A/P-loop; other site 326425000635 ATP binding site [chemical binding]; other site 326425000636 Q-loop/lid; other site 326425000637 ABC transporter signature motif; other site 326425000638 Walker B; other site 326425000639 D-loop; other site 326425000640 H-loop/switch region; other site 326425000641 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 326425000642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326425000643 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326425000644 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 326425000645 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 326425000646 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326425000647 Coenzyme A binding pocket [chemical binding]; other site 326425000648 Penicillinase repressor; Region: Pencillinase_R; cl17580 326425000649 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 326425000650 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326425000651 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326425000652 motif II; other site 326425000653 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 326425000654 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 326425000655 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 326425000656 Presynaptic Site I dimer interface [polypeptide binding]; other site 326425000657 catalytic residues [active] 326425000658 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 326425000659 Synaptic Flat tetramer interface [polypeptide binding]; other site 326425000660 Synaptic Site I dimer interface [polypeptide binding]; other site 326425000661 DNA binding site [nucleotide binding] 326425000662 Homeodomain-like domain; Region: HTH_23; pfam13384 326425000663 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 326425000664 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 326425000665 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 326425000666 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 326425000667 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326425000668 MarR family; Region: MarR_2; pfam12802 326425000669 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 326425000670 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 326425000671 dimer interface [polypeptide binding]; other site 326425000672 active site 326425000673 CoA binding pocket [chemical binding]; other site 326425000674 acyl carrier protein; Provisional; Region: acpP; PRK00982 326425000675 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 326425000676 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326425000677 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 326425000678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326425000679 NAD(P) binding site [chemical binding]; other site 326425000680 active site 326425000681 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 326425000682 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 326425000683 dimer interface [polypeptide binding]; other site 326425000684 active site 326425000685 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 326425000686 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 326425000687 carboxyltransferase (CT) interaction site; other site 326425000688 biotinylation site [posttranslational modification]; other site 326425000689 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 326425000690 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 326425000691 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326425000692 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326425000693 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 326425000694 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 326425000695 FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764 326425000696 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 326425000697 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 326425000698 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 326425000699 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 326425000700 NAD binding site [chemical binding]; other site 326425000701 homotetramer interface [polypeptide binding]; other site 326425000702 homodimer interface [polypeptide binding]; other site 326425000703 substrate binding site [chemical binding]; other site 326425000704 active site 326425000705 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 326425000706 HTH domain; Region: HTH_11; pfam08279 326425000707 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 326425000708 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 326425000709 BioY family; Region: BioY; pfam02632 326425000710 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326425000711 active site 326425000712 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 326425000713 FAD binding site [chemical binding]; other site 326425000714 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 326425000715 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 326425000716 THF binding site; other site 326425000717 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 326425000718 substrate binding site [chemical binding]; other site 326425000719 THF binding site; other site 326425000720 zinc-binding site [ion binding]; other site 326425000721 S-ribosylhomocysteinase; Provisional; Region: PRK02260 326425000722 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 326425000723 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326425000724 active site 326425000725 DNA binding site [nucleotide binding] 326425000726 Int/Topo IB signature motif; other site 326425000727 RelB antitoxin; Region: RelB; cl01171 326425000728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 326425000729 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 326425000730 ThiF family; Region: ThiF; pfam00899 326425000731 ATP binding site [chemical binding]; other site 326425000732 YcaO-like family; Region: YcaO; pfam02624 326425000733 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326425000734 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 326425000735 Walker A/P-loop; other site 326425000736 ATP binding site [chemical binding]; other site 326425000737 Q-loop/lid; other site 326425000738 ABC transporter signature motif; other site 326425000739 Walker B; other site 326425000740 D-loop; other site 326425000741 H-loop/switch region; other site 326425000742 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 326425000743 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326425000744 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 326425000745 Walker A/P-loop; other site 326425000746 ATP binding site [chemical binding]; other site 326425000747 Q-loop/lid; other site 326425000748 ABC transporter signature motif; other site 326425000749 Walker B; other site 326425000750 D-loop; other site 326425000751 H-loop/switch region; other site 326425000752 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 326425000753 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 326425000754 dimer interface [polypeptide binding]; other site 326425000755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326425000756 catalytic residue [active] 326425000757 cystathionine beta-lyase; Provisional; Region: PRK07671 326425000758 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 326425000759 homodimer interface [polypeptide binding]; other site 326425000760 substrate-cofactor binding pocket; other site 326425000761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326425000762 catalytic residue [active] 326425000763 serine O-acetyltransferase; Region: cysE; TIGR01172 326425000764 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 326425000765 trimer interface [polypeptide binding]; other site 326425000766 active site 326425000767 substrate binding site [chemical binding]; other site 326425000768 CoA binding site [chemical binding]; other site 326425000769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326425000770 active site 326425000771 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 326425000772 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 326425000773 dimer interface [polypeptide binding]; other site 326425000774 putative radical transfer pathway; other site 326425000775 diiron center [ion binding]; other site 326425000776 tyrosyl radical; other site 326425000777 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 326425000778 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 326425000779 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 326425000780 Class I ribonucleotide reductase; Region: RNR_I; cd01679 326425000781 active site 326425000782 dimer interface [polypeptide binding]; other site 326425000783 catalytic residues [active] 326425000784 effector binding site; other site 326425000785 R2 peptide binding site; other site 326425000786 drug efflux system protein MdtG; Provisional; Region: PRK09874 326425000787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326425000788 putative substrate translocation pore; other site 326425000789 Peptidase family M1; Region: Peptidase_M1; pfam01433 326425000790 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 326425000791 Zn binding site [ion binding]; other site 326425000792 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 326425000793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326425000794 putative substrate translocation pore; other site 326425000795 hypothetical protein; Validated; Region: PRK02101 326425000796 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326425000797 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326425000798 catalytic core [active] 326425000799 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326425000800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326425000801 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 326425000802 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 326425000803 FtsX-like permease family; Region: FtsX; pfam02687 326425000804 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326425000805 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326425000806 Walker A/P-loop; other site 326425000807 ATP binding site [chemical binding]; other site 326425000808 Q-loop/lid; other site 326425000809 ABC transporter signature motif; other site 326425000810 Walker B; other site 326425000811 D-loop; other site 326425000812 H-loop/switch region; other site 326425000813 Peptidase family C69; Region: Peptidase_C69; cl17793 326425000814 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326425000815 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326425000816 WHG domain; Region: WHG; pfam13305 326425000817 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 326425000818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326425000819 putative substrate translocation pore; other site 326425000820 Predicted flavoprotein [General function prediction only]; Region: COG0431 326425000821 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 326425000822 Predicted flavoprotein [General function prediction only]; Region: COG0431 326425000823 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 326425000824 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 326425000825 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 326425000826 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 326425000827 ApbE family; Region: ApbE; pfam02424 326425000828 Colicin V production protein; Region: Colicin_V; pfam02674 326425000829 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 326425000830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326425000831 S-adenosylmethionine binding site [chemical binding]; other site 326425000832 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 326425000833 ParB-like nuclease domain; Region: ParB; smart00470 326425000834 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 326425000835 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326425000836 P-loop; other site 326425000837 Magnesium ion binding site [ion binding]; other site 326425000838 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326425000839 Magnesium ion binding site [ion binding]; other site 326425000840 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 326425000841 ParB-like nuclease domain; Region: ParB; smart00470 326425000842 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 326425000843 GTP-binding protein YchF; Reviewed; Region: PRK09601 326425000844 YchF GTPase; Region: YchF; cd01900 326425000845 G1 box; other site 326425000846 GTP/Mg2+ binding site [chemical binding]; other site 326425000847 Switch I region; other site 326425000848 G2 box; other site 326425000849 Switch II region; other site 326425000850 G3 box; other site 326425000851 G4 box; other site 326425000852 G5 box; other site 326425000853 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 326425000854 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 326425000855 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326425000856 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326425000857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326425000858 Walker A/P-loop; other site 326425000859 ATP binding site [chemical binding]; other site 326425000860 Q-loop/lid; other site 326425000861 ABC transporter signature motif; other site 326425000862 Walker B; other site 326425000863 D-loop; other site 326425000864 H-loop/switch region; other site 326425000865 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326425000866 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326425000867 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 326425000868 Walker A/P-loop; other site 326425000869 ATP binding site [chemical binding]; other site 326425000870 Q-loop/lid; other site 326425000871 ABC transporter signature motif; other site 326425000872 Walker B; other site 326425000873 D-loop; other site 326425000874 H-loop/switch region; other site 326425000875 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326425000876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326425000877 active site 326425000878 phosphorylation site [posttranslational modification] 326425000879 intermolecular recognition site; other site 326425000880 dimerization interface [polypeptide binding]; other site 326425000881 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326425000882 DNA binding site [nucleotide binding] 326425000883 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326425000884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326425000885 dimer interface [polypeptide binding]; other site 326425000886 phosphorylation site [posttranslational modification] 326425000887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326425000888 ATP binding site [chemical binding]; other site 326425000889 Mg2+ binding site [ion binding]; other site 326425000890 G-X-G motif; other site 326425000891 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 326425000892 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 326425000893 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326425000894 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 326425000895 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 326425000896 aspartate racemase; Region: asp_race; TIGR00035 326425000897 Enterocin A Immunity; Region: EntA_Immun; pfam08951 326425000898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326425000899 salt bridge; other site 326425000900 non-specific DNA binding site [nucleotide binding]; other site 326425000901 sequence-specific DNA binding site [nucleotide binding]; other site 326425000902 RelB antitoxin; Region: RelB; cl01171 326425000903 RelB antitoxin; Region: RelB; cl01171 326425000904 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 326425000905 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 326425000906 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 326425000907 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 326425000908 putative substrate binding site [chemical binding]; other site 326425000909 putative ATP binding site [chemical binding]; other site 326425000910 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 326425000911 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 326425000912 active site 326425000913 phosphorylation site [posttranslational modification] 326425000914 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 326425000915 active site 326425000916 P-loop; other site 326425000917 phosphorylation site [posttranslational modification] 326425000918 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 326425000919 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326425000920 dimerization interface [polypeptide binding]; other site 326425000921 putative DNA binding site [nucleotide binding]; other site 326425000922 putative Zn2+ binding site [ion binding]; other site 326425000923 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326425000924 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 326425000925 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 326425000926 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 326425000927 dimer interface [polypeptide binding]; other site 326425000928 putative PBP binding regions; other site 326425000929 ABC-ATPase subunit interface; other site 326425000930 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 326425000931 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 326425000932 Enterocin A Immunity; Region: EntA_Immun; pfam08951 326425000933 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 326425000934 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 326425000935 active site 326425000936 Zn binding site [ion binding]; other site 326425000937 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 326425000938 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326425000939 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 326425000940 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 326425000941 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326425000942 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326425000943 Walker A/P-loop; other site 326425000944 ATP binding site [chemical binding]; other site 326425000945 Q-loop/lid; other site 326425000946 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326425000947 ABC transporter signature motif; other site 326425000948 Walker B; other site 326425000949 D-loop; other site 326425000950 ABC transporter; Region: ABC_tran_2; pfam12848 326425000951 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326425000952 Uncharacterized conserved protein [Function unknown]; Region: COG2966 326425000953 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 326425000954 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 326425000955 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 326425000956 putative active site [active] 326425000957 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 326425000958 MFS/sugar transport protein; Region: MFS_2; pfam13347 326425000959 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 326425000960 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 326425000961 catalytic site [active] 326425000962 G-X2-G-X-G-K; other site 326425000963 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 326425000964 NlpC/P60 family; Region: NLPC_P60; pfam00877 326425000965 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 326425000966 NlpC/P60 family; Region: NLPC_P60; pfam00877 326425000967 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 326425000968 NlpC/P60 family; Region: NLPC_P60; pfam00877 326425000969 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 326425000970 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 326425000971 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 326425000972 HflX GTPase family; Region: HflX; cd01878 326425000973 G1 box; other site 326425000974 GTP/Mg2+ binding site [chemical binding]; other site 326425000975 Switch I region; other site 326425000976 G2 box; other site 326425000977 G3 box; other site 326425000978 Switch II region; other site 326425000979 G4 box; other site 326425000980 G5 box; other site 326425000981 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 326425000982 Chain length determinant protein; Region: Wzz; cl15801 326425000983 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 326425000984 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 326425000985 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 326425000986 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 326425000987 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326425000988 active site 326425000989 Bacterial sugar transferase; Region: Bac_transf; pfam02397 326425000990 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326425000991 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 326425000992 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 326425000993 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326425000994 active site 326425000995 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 326425000996 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326425000997 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 326425000998 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326425000999 active site 326425001000 LicD family; Region: LicD; pfam04991 326425001001 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 326425001002 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 326425001003 Probable Catalytic site; other site 326425001004 metal-binding site 326425001005 Core-2/I-Branching enzyme; Region: Branch; pfam02485 326425001006 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 326425001007 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 326425001008 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 326425001009 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326425001010 active site 326425001011 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 326425001012 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 326425001013 active site 326425001014 metal-binding site 326425001015 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 326425001016 Phosphotransferase enzyme family; Region: APH; pfam01636 326425001017 active site 326425001018 ATP binding site [chemical binding]; other site 326425001019 substrate binding site [chemical binding]; other site 326425001020 dimer interface [polypeptide binding]; other site 326425001021 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 326425001022 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 326425001023 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 326425001024 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 326425001025 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 326425001026 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326425001027 DNA binding residues [nucleotide binding] 326425001028 dimer interface [polypeptide binding]; other site 326425001029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326425001030 S-adenosylmethionine binding site [chemical binding]; other site 326425001031 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 326425001032 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 326425001033 NAD binding site [chemical binding]; other site 326425001034 substrate binding site [chemical binding]; other site 326425001035 homodimer interface [polypeptide binding]; other site 326425001036 active site 326425001037 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 326425001038 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 326425001039 substrate binding site; other site 326425001040 tetramer interface; other site 326425001041 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 326425001042 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 326425001043 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 326425001044 NADP binding site [chemical binding]; other site 326425001045 active site 326425001046 putative substrate binding site [chemical binding]; other site 326425001047 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 326425001048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326425001049 putative substrate translocation pore; other site 326425001050 multidrug efflux protein; Reviewed; Region: PRK09577 326425001051 Amino acid permease; Region: AA_permease_2; pfam13520 326425001052 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 326425001053 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 326425001054 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326425001055 catalytic residue [active] 326425001056 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 326425001057 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 326425001058 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 326425001059 active site 326425001060 tetramer interface; other site 326425001061 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 326425001062 active site 326425001063 homodimer interface [polypeptide binding]; other site 326425001064 Predicted membrane protein [Function unknown]; Region: COG4640 326425001065 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326425001066 catalytic core [active] 326425001067 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 326425001068 active site 326425001069 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 326425001070 Part of AAA domain; Region: AAA_19; pfam13245 326425001071 Family description; Region: UvrD_C_2; pfam13538 326425001072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425001073 dimer interface [polypeptide binding]; other site 326425001074 conserved gate region; other site 326425001075 putative PBP binding loops; other site 326425001076 ABC-ATPase subunit interface; other site 326425001077 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326425001078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326425001079 Walker A/P-loop; other site 326425001080 ATP binding site [chemical binding]; other site 326425001081 Q-loop/lid; other site 326425001082 ABC transporter signature motif; other site 326425001083 Walker B; other site 326425001084 D-loop; other site 326425001085 H-loop/switch region; other site 326425001086 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326425001087 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326425001088 substrate binding pocket [chemical binding]; other site 326425001089 membrane-bound complex binding site; other site 326425001090 hinge residues; other site 326425001091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326425001092 Coenzyme A binding pocket [chemical binding]; other site 326425001093 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 326425001094 active site 326425001095 catalytic triad [active] 326425001096 oxyanion hole [active] 326425001097 pantothenate kinase; Provisional; Region: PRK05439 326425001098 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 326425001099 ATP-binding site [chemical binding]; other site 326425001100 CoA-binding site [chemical binding]; other site 326425001101 Mg2+-binding site [ion binding]; other site 326425001102 elongation factor P; Validated; Region: PRK00529 326425001103 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 326425001104 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 326425001105 RNA binding site [nucleotide binding]; other site 326425001106 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 326425001107 RNA binding site [nucleotide binding]; other site 326425001108 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 326425001109 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 326425001110 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 326425001111 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 326425001112 adenosine deaminase; Provisional; Region: PRK09358 326425001113 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 326425001114 active site 326425001115 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 326425001116 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 326425001117 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 326425001118 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 326425001119 active site 326425001120 catalytic site [active] 326425001121 substrate binding site [chemical binding]; other site 326425001122 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 326425001123 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 326425001124 Peptidase family C69; Region: Peptidase_C69; pfam03577 326425001125 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 326425001126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326425001127 Walker A/P-loop; other site 326425001128 ATP binding site [chemical binding]; other site 326425001129 Q-loop/lid; other site 326425001130 ABC transporter signature motif; other site 326425001131 Walker B; other site 326425001132 D-loop; other site 326425001133 H-loop/switch region; other site 326425001134 TOBE domain; Region: TOBE_2; pfam08402 326425001135 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 326425001136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425001137 dimer interface [polypeptide binding]; other site 326425001138 conserved gate region; other site 326425001139 putative PBP binding loops; other site 326425001140 ABC-ATPase subunit interface; other site 326425001141 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326425001142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425001143 dimer interface [polypeptide binding]; other site 326425001144 conserved gate region; other site 326425001145 ABC-ATPase subunit interface; other site 326425001146 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 326425001147 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 326425001148 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 326425001149 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 326425001150 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 326425001151 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 326425001152 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 326425001153 oligomer interface [polypeptide binding]; other site 326425001154 Cl binding site [ion binding]; other site 326425001155 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 326425001156 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326425001157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326425001158 MMPL family; Region: MMPL; pfam03176 326425001159 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 326425001160 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 326425001161 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 326425001162 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 326425001163 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 326425001164 Double zinc ribbon; Region: DZR; pfam12773 326425001165 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 326425001166 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 326425001167 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 326425001168 NAD(P) binding site [chemical binding]; other site 326425001169 catalytic residues [active] 326425001170 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 326425001171 Uncharacterized conserved protein [Function unknown]; Region: COG0398 326425001172 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 326425001173 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326425001174 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 326425001175 seryl-tRNA synthetase; Provisional; Region: PRK05431 326425001176 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 326425001177 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 326425001178 dimer interface [polypeptide binding]; other site 326425001179 active site 326425001180 motif 1; other site 326425001181 motif 2; other site 326425001182 motif 3; other site 326425001183 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 326425001184 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 326425001185 active pocket/dimerization site; other site 326425001186 active site 326425001187 phosphorylation site [posttranslational modification] 326425001188 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 326425001189 active site 326425001190 phosphorylation site [posttranslational modification] 326425001191 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 326425001192 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 326425001193 Domain of unknown function (DUF956); Region: DUF956; pfam06115 326425001194 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326425001195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326425001196 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 326425001197 dimerization interface [polypeptide binding]; other site 326425001198 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 326425001199 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 326425001200 putative trimer interface [polypeptide binding]; other site 326425001201 putative CoA binding site [chemical binding]; other site 326425001202 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 326425001203 Spore germination protein; Region: Spore_permease; cl17796 326425001204 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 326425001205 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 326425001206 putative catalytic cysteine [active] 326425001207 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 326425001208 putative active site [active] 326425001209 metal binding site [ion binding]; metal-binding site 326425001210 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 326425001211 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 326425001212 glutaminase active site [active] 326425001213 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 326425001214 dimer interface [polypeptide binding]; other site 326425001215 active site 326425001216 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 326425001217 dimer interface [polypeptide binding]; other site 326425001218 active site 326425001219 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 326425001220 propionate/acetate kinase; Provisional; Region: PRK12379 326425001221 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 326425001222 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 326425001223 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 326425001224 active site 326425001225 Ap4A binding cleft/pocket [chemical binding]; other site 326425001226 P4 phosphate binding site; other site 326425001227 nudix motif; other site 326425001228 putative P2/P3 phosphate binding site [ion binding]; other site 326425001229 TIGR02452 family protein; Region: TIGR02452 326425001230 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 326425001231 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 326425001232 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 326425001233 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326425001234 DNA-binding site [nucleotide binding]; DNA binding site 326425001235 UTRA domain; Region: UTRA; pfam07702 326425001236 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 326425001237 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 326425001238 active site 326425001239 dimer interface [polypeptide binding]; other site 326425001240 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 326425001241 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326425001242 catalytic core [active] 326425001243 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326425001244 catalytic core [active] 326425001245 Uncharacterized conserved protein [Function unknown]; Region: COG1359 326425001246 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 326425001247 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 326425001248 active site 326425001249 catalytic site [active] 326425001250 Bacterial surface layer protein; Region: SLAP; pfam03217 326425001251 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 326425001252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326425001253 DNA-binding site [nucleotide binding]; DNA binding site 326425001254 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 326425001255 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326425001256 active site 326425001257 nucleotide binding site [chemical binding]; other site 326425001258 HIGH motif; other site 326425001259 KMSKS motif; other site 326425001260 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 326425001261 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 326425001262 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326425001263 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 326425001264 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 326425001265 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 326425001266 active site 326425001267 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 326425001268 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 326425001269 homodimer interface [polypeptide binding]; other site 326425001270 NAD binding pocket [chemical binding]; other site 326425001271 ATP binding pocket [chemical binding]; other site 326425001272 Mg binding site [ion binding]; other site 326425001273 active-site loop [active] 326425001274 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 326425001275 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 326425001276 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 326425001277 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 326425001278 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 326425001279 hypothetical protein; Provisional; Region: PRK04351 326425001280 SprT homologues; Region: SprT; cl01182 326425001281 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 326425001282 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 326425001283 Part of AAA domain; Region: AAA_19; pfam13245 326425001284 Family description; Region: UvrD_C_2; pfam13538 326425001285 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 326425001286 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 326425001287 nucleotide binding pocket [chemical binding]; other site 326425001288 K-X-D-G motif; other site 326425001289 catalytic site [active] 326425001290 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 326425001291 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 326425001292 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 326425001293 Dimer interface [polypeptide binding]; other site 326425001294 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 326425001295 putative dimer interface [polypeptide binding]; other site 326425001296 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 326425001297 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 326425001298 putative dimer interface [polypeptide binding]; other site 326425001299 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 326425001300 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 326425001301 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 326425001302 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 326425001303 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 326425001304 GatB domain; Region: GatB_Yqey; pfam02637 326425001305 putative lipid kinase; Reviewed; Region: PRK13337 326425001306 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 326425001307 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 326425001308 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 326425001309 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 326425001310 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 326425001311 catalytic residues [active] 326425001312 catalytic nucleophile [active] 326425001313 Presynaptic Site I dimer interface [polypeptide binding]; other site 326425001314 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 326425001315 Synaptic Flat tetramer interface [polypeptide binding]; other site 326425001316 Synaptic Site I dimer interface [polypeptide binding]; other site 326425001317 DNA binding site [nucleotide binding] 326425001318 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 326425001319 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 326425001320 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 326425001321 Walker A/P-loop; other site 326425001322 ATP binding site [chemical binding]; other site 326425001323 Q-loop/lid; other site 326425001324 ABC transporter signature motif; other site 326425001325 Walker B; other site 326425001326 D-loop; other site 326425001327 H-loop/switch region; other site 326425001328 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 326425001329 FeS assembly protein SufD; Region: sufD; TIGR01981 326425001330 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 326425001331 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 326425001332 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326425001333 catalytic residue [active] 326425001334 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 326425001335 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 326425001336 trimerization site [polypeptide binding]; other site 326425001337 active site 326425001338 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 326425001339 FeS assembly protein SufB; Region: sufB; TIGR01980 326425001340 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 326425001341 Enterocin A Immunity; Region: EntA_Immun; pfam08951 326425001342 putative phosphoketolase; Provisional; Region: PRK05261 326425001343 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 326425001344 TPP-binding site; other site 326425001345 XFP C-terminal domain; Region: XFP_C; pfam09363 326425001346 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 326425001347 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 326425001348 active site 326425001349 nucleophile elbow; other site 326425001350 CAAX protease self-immunity; Region: Abi; pfam02517 326425001351 Domain of unknown function DUF21; Region: DUF21; pfam01595 326425001352 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 326425001353 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 326425001354 Transporter associated domain; Region: CorC_HlyC; smart01091 326425001355 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326425001356 active site 326425001357 amino acid transporter; Region: 2A0306; TIGR00909 326425001358 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 326425001359 active site 326425001360 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 326425001361 DEAD-like helicases superfamily; Region: DEXDc; smart00487 326425001362 DEAD/DEAH box helicase; Region: DEAD; pfam00270 326425001363 ATP binding site [chemical binding]; other site 326425001364 putative Mg++ binding site [ion binding]; other site 326425001365 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326425001366 nucleotide binding region [chemical binding]; other site 326425001367 ATP-binding site [chemical binding]; other site 326425001368 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 326425001369 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 326425001370 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 326425001371 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 326425001372 active site 326425001373 homodimer interface [polypeptide binding]; other site 326425001374 Predicted membrane protein [Function unknown]; Region: COG2246 326425001375 GtrA-like protein; Region: GtrA; pfam04138 326425001376 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 326425001377 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 326425001378 methionine aminopeptidase; Provisional; Region: PRK08671 326425001379 active site 326425001380 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 326425001381 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 326425001382 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 326425001383 active site 326425001384 tetramer interface; other site 326425001385 putative acyltransferase; Provisional; Region: PRK05790 326425001386 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 326425001387 dimer interface [polypeptide binding]; other site 326425001388 active site 326425001389 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 326425001390 homodimer interface [polypeptide binding]; other site 326425001391 catalytic residues [active] 326425001392 NAD binding site [chemical binding]; other site 326425001393 substrate binding pocket [chemical binding]; other site 326425001394 flexible flap; other site 326425001395 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 326425001396 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 326425001397 dimer interface [polypeptide binding]; other site 326425001398 active site 326425001399 hydrolase; Region: PLN02811 326425001400 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 326425001401 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 326425001402 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 326425001403 Helix-turn-helix domain; Region: HTH_19; pfam12844 326425001404 non-specific DNA binding site [nucleotide binding]; other site 326425001405 salt bridge; other site 326425001406 sequence-specific DNA binding site [nucleotide binding]; other site 326425001407 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 326425001408 active site 326425001409 tetramer interface [polypeptide binding]; other site 326425001410 K+ potassium transporter; Region: K_trans; pfam02705 326425001411 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 326425001412 tetramer (dimer of dimers) interface [polypeptide binding]; other site 326425001413 active site 326425001414 dimer interface [polypeptide binding]; other site 326425001415 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 326425001416 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 326425001417 substrate binding site [chemical binding]; other site 326425001418 dimer interface [polypeptide binding]; other site 326425001419 ATP binding site [chemical binding]; other site 326425001420 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 326425001421 nucleotide binding site/active site [active] 326425001422 HIT family signature motif; other site 326425001423 catalytic residue [active] 326425001424 hypothetical protein; Validated; Region: PRK00194 326425001425 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 326425001426 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 326425001427 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 326425001428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425001429 dimer interface [polypeptide binding]; other site 326425001430 conserved gate region; other site 326425001431 putative PBP binding loops; other site 326425001432 ABC-ATPase subunit interface; other site 326425001433 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 326425001434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425001435 dimer interface [polypeptide binding]; other site 326425001436 conserved gate region; other site 326425001437 putative PBP binding loops; other site 326425001438 ABC-ATPase subunit interface; other site 326425001439 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326425001440 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326425001441 substrate binding pocket [chemical binding]; other site 326425001442 membrane-bound complex binding site; other site 326425001443 hinge residues; other site 326425001444 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326425001445 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 326425001446 Walker A/P-loop; other site 326425001447 ATP binding site [chemical binding]; other site 326425001448 Q-loop/lid; other site 326425001449 ABC transporter signature motif; other site 326425001450 Walker B; other site 326425001451 D-loop; other site 326425001452 H-loop/switch region; other site 326425001453 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 326425001454 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326425001455 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326425001456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326425001457 Walker A/P-loop; other site 326425001458 ATP binding site [chemical binding]; other site 326425001459 Q-loop/lid; other site 326425001460 ABC transporter signature motif; other site 326425001461 Walker B; other site 326425001462 D-loop; other site 326425001463 H-loop/switch region; other site 326425001464 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326425001465 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326425001466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326425001467 Walker A/P-loop; other site 326425001468 ATP binding site [chemical binding]; other site 326425001469 Q-loop/lid; other site 326425001470 ABC transporter signature motif; other site 326425001471 Walker B; other site 326425001472 D-loop; other site 326425001473 H-loop/switch region; other site 326425001474 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 326425001475 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326425001476 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326425001477 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326425001478 substrate binding pocket [chemical binding]; other site 326425001479 membrane-bound complex binding site; other site 326425001480 hinge residues; other site 326425001481 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 326425001482 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 326425001483 catalytic triad [active] 326425001484 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 326425001485 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326425001486 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326425001487 ABC transporter; Region: ABC_tran_2; pfam12848 326425001488 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326425001489 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 326425001490 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 326425001491 oligomer interface [polypeptide binding]; other site 326425001492 active site 326425001493 metal binding site [ion binding]; metal-binding site 326425001494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326425001495 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326425001496 putative substrate translocation pore; other site 326425001497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326425001498 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326425001499 putative substrate translocation pore; other site 326425001500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326425001501 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 326425001502 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326425001503 active site 326425001504 uracil transporter; Provisional; Region: PRK10720 326425001505 Sulfate transporter family; Region: Sulfate_transp; pfam00916 326425001506 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326425001507 Coenzyme A binding pocket [chemical binding]; other site 326425001508 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 326425001509 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 326425001510 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 326425001511 Predicted transcriptional regulators [Transcription]; Region: COG1695 326425001512 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326425001513 putative Zn2+ binding site [ion binding]; other site 326425001514 putative DNA binding site [nucleotide binding]; other site 326425001515 Predicted amidohydrolase [General function prediction only]; Region: COG0388 326425001516 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 326425001517 putative active site [active] 326425001518 catalytic triad [active] 326425001519 putative dimer interface [polypeptide binding]; other site 326425001520 transaminase; Reviewed; Region: PRK08068 326425001521 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326425001522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326425001523 homodimer interface [polypeptide binding]; other site 326425001524 catalytic residue [active] 326425001525 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 326425001526 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 326425001527 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 326425001528 TRAM domain; Region: TRAM; cl01282 326425001529 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 326425001530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326425001531 S-adenosylmethionine binding site [chemical binding]; other site 326425001532 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 326425001533 H+ Antiporter protein; Region: 2A0121; TIGR00900 326425001534 AAA domain; Region: AAA_17; pfam13207 326425001535 AAA domain; Region: AAA_18; pfam13238 326425001536 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 326425001537 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 326425001538 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 326425001539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326425001540 S-adenosylmethionine binding site [chemical binding]; other site 326425001541 recombination regulator RecX; Provisional; Region: recX; PRK14135 326425001542 Flavoprotein; Region: Flavoprotein; cl08021 326425001543 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 326425001544 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 326425001545 Transporter associated domain; Region: CorC_HlyC; pfam03471 326425001546 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 326425001547 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 326425001548 G1 box; other site 326425001549 putative GEF interaction site [polypeptide binding]; other site 326425001550 GTP/Mg2+ binding site [chemical binding]; other site 326425001551 Switch I region; other site 326425001552 G2 box; other site 326425001553 G3 box; other site 326425001554 Switch II region; other site 326425001555 G4 box; other site 326425001556 G5 box; other site 326425001557 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 326425001558 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 326425001559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326425001560 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 326425001561 Walker A motif; other site 326425001562 ATP binding site [chemical binding]; other site 326425001563 Walker B motif; other site 326425001564 arginine finger; other site 326425001565 UvrB/uvrC motif; Region: UVR; pfam02151 326425001566 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326425001567 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 326425001568 Walker A motif; other site 326425001569 ATP binding site [chemical binding]; other site 326425001570 Walker B motif; other site 326425001571 arginine finger; other site 326425001572 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 326425001573 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 326425001574 dimerization domain swap beta strand [polypeptide binding]; other site 326425001575 regulatory protein interface [polypeptide binding]; other site 326425001576 active site 326425001577 regulatory phosphorylation site [posttranslational modification]; other site 326425001578 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 326425001579 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 326425001580 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 326425001581 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 326425001582 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 326425001583 ArsC family; Region: ArsC; pfam03960 326425001584 putative catalytic residues [active] 326425001585 thiol/disulfide switch; other site 326425001586 adaptor protein; Provisional; Region: PRK02315 326425001587 Thioredoxin; Region: Thioredoxin_5; pfam13743 326425001588 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 326425001589 putative active site [active] 326425001590 putative metal binding residues [ion binding]; other site 326425001591 signature motif; other site 326425001592 putative triphosphate binding site [ion binding]; other site 326425001593 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 326425001594 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 326425001595 synthetase active site [active] 326425001596 NTP binding site [chemical binding]; other site 326425001597 metal binding site [ion binding]; metal-binding site 326425001598 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 326425001599 ATP-NAD kinase; Region: NAD_kinase; pfam01513 326425001600 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 326425001601 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 326425001602 active site 326425001603 myosin-cross-reactive antigen; Provisional; Region: PRK13977 326425001604 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 326425001605 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 326425001606 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 326425001607 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 326425001608 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326425001609 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 326425001610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326425001611 motif II; other site 326425001612 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 326425001613 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 326425001614 Domain of unknown function DUF20; Region: UPF0118; pfam01594 326425001615 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 326425001616 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 326425001617 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 326425001618 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 326425001619 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326425001620 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 326425001621 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 326425001622 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 326425001623 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 326425001624 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 326425001625 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 326425001626 classical (c) SDRs; Region: SDR_c; cd05233 326425001627 NAD(P) binding site [chemical binding]; other site 326425001628 active site 326425001629 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 326425001630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326425001631 non-specific DNA binding site [nucleotide binding]; other site 326425001632 salt bridge; other site 326425001633 sequence-specific DNA binding site [nucleotide binding]; other site 326425001634 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 326425001635 recombinase A; Provisional; Region: recA; PRK09354 326425001636 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 326425001637 hexamer interface [polypeptide binding]; other site 326425001638 Walker A motif; other site 326425001639 ATP binding site [chemical binding]; other site 326425001640 Walker B motif; other site 326425001641 phosphodiesterase; Provisional; Region: PRK12704 326425001642 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326425001643 Zn2+ binding site [ion binding]; other site 326425001644 Mg2+ binding site [ion binding]; other site 326425001645 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 326425001646 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 326425001647 Mg++ binding site [ion binding]; other site 326425001648 putative catalytic motif [active] 326425001649 substrate binding site [chemical binding]; other site 326425001650 Uncharacterized conserved protein [Function unknown]; Region: COG1739 326425001651 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 326425001652 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 326425001653 DEAD-like helicases superfamily; Region: DEXDc; smart00487 326425001654 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326425001655 ATP binding site [chemical binding]; other site 326425001656 putative Mg++ binding site [ion binding]; other site 326425001657 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326425001658 nucleotide binding region [chemical binding]; other site 326425001659 ATP-binding site [chemical binding]; other site 326425001660 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 326425001661 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326425001662 active site 326425001663 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 326425001664 30S subunit binding site; other site 326425001665 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 326425001666 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 326425001667 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326425001668 nucleotide binding region [chemical binding]; other site 326425001669 ATP-binding site [chemical binding]; other site 326425001670 peptide chain release factor 2; Provisional; Region: PRK05589 326425001671 This domain is found in peptide chain release factors; Region: PCRF; smart00937 326425001672 RF-1 domain; Region: RF-1; pfam00472 326425001673 HPr kinase/phosphorylase; Provisional; Region: PRK05428 326425001674 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 326425001675 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 326425001676 Hpr binding site; other site 326425001677 active site 326425001678 homohexamer subunit interaction site [polypeptide binding]; other site 326425001679 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 326425001680 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 326425001681 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 326425001682 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 326425001683 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 326425001684 sulfate 1 binding site; other site 326425001685 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 326425001686 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 326425001687 active site 326425001688 substrate binding site [chemical binding]; other site 326425001689 metal binding site [ion binding]; metal-binding site 326425001690 excinuclease ABC subunit B; Provisional; Region: PRK05298 326425001691 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326425001692 ATP binding site [chemical binding]; other site 326425001693 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326425001694 nucleotide binding region [chemical binding]; other site 326425001695 ATP-binding site [chemical binding]; other site 326425001696 Ultra-violet resistance protein B; Region: UvrB; pfam12344 326425001697 UvrB/uvrC motif; Region: UVR; pfam02151 326425001698 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 326425001699 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 326425001700 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 326425001701 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 326425001702 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 326425001703 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 326425001704 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 326425001705 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 326425001706 putative substrate binding pocket [chemical binding]; other site 326425001707 dimer interface [polypeptide binding]; other site 326425001708 phosphate binding site [ion binding]; other site 326425001709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 326425001710 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 326425001711 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 326425001712 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 326425001713 oligomer interface [polypeptide binding]; other site 326425001714 active site residues [active] 326425001715 SH3-like domain; Region: SH3_8; pfam13457 326425001716 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 326425001717 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 326425001718 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 326425001719 active site 326425001720 motif I; other site 326425001721 motif II; other site 326425001722 Predicted transcriptional regulator [Transcription]; Region: COG3388 326425001723 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 326425001724 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 326425001725 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 326425001726 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 326425001727 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 326425001728 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 326425001729 Phosphoglycerate kinase; Region: PGK; pfam00162 326425001730 substrate binding site [chemical binding]; other site 326425001731 hinge regions; other site 326425001732 ADP binding site [chemical binding]; other site 326425001733 catalytic site [active] 326425001734 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 326425001735 triosephosphate isomerase; Provisional; Region: PRK14567 326425001736 substrate binding site [chemical binding]; other site 326425001737 dimer interface [polypeptide binding]; other site 326425001738 catalytic triad [active] 326425001739 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326425001740 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 326425001741 active site 326425001742 motif I; other site 326425001743 motif II; other site 326425001744 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 326425001745 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 326425001746 ligand binding site [chemical binding]; other site 326425001747 active site 326425001748 UGI interface [polypeptide binding]; other site 326425001749 catalytic site [active] 326425001750 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 326425001751 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 326425001752 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 326425001753 active site 326425001754 catalytic site [active] 326425001755 substrate binding site [chemical binding]; other site 326425001756 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 326425001757 FAD binding domain; Region: FAD_binding_4; pfam01565 326425001758 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 326425001759 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 326425001760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326425001761 Walker A/P-loop; other site 326425001762 ATP binding site [chemical binding]; other site 326425001763 Q-loop/lid; other site 326425001764 ABC transporter signature motif; other site 326425001765 Walker B; other site 326425001766 D-loop; other site 326425001767 H-loop/switch region; other site 326425001768 TOBE domain; Region: TOBE_2; pfam08402 326425001769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425001770 dimer interface [polypeptide binding]; other site 326425001771 conserved gate region; other site 326425001772 putative PBP binding loops; other site 326425001773 ABC-ATPase subunit interface; other site 326425001774 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 326425001775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425001776 dimer interface [polypeptide binding]; other site 326425001777 conserved gate region; other site 326425001778 putative PBP binding loops; other site 326425001779 ABC-ATPase subunit interface; other site 326425001780 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 326425001781 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 326425001782 Uncharacterized conserved protein [Function unknown]; Region: COG1624 326425001783 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 326425001784 YbbR-like protein; Region: YbbR; pfam07949 326425001785 YbbR-like protein; Region: YbbR; pfam07949 326425001786 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 326425001787 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 326425001788 active site 326425001789 substrate binding site [chemical binding]; other site 326425001790 metal binding site [ion binding]; metal-binding site 326425001791 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 326425001792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326425001793 active site 326425001794 motif I; other site 326425001795 motif II; other site 326425001796 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 326425001797 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 326425001798 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326425001799 active site 326425001800 motif I; other site 326425001801 motif II; other site 326425001802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326425001803 clostripain; Region: clostrip; TIGR02806 326425001804 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 326425001805 Low molecular weight phosphatase family; Region: LMWPc; cd00115 326425001806 active site 326425001807 glycerate kinase; Region: TIGR00045 326425001808 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 326425001809 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 326425001810 active site turn [active] 326425001811 phosphorylation site [posttranslational modification] 326425001812 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 326425001813 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 326425001814 HPr interaction site; other site 326425001815 glycerol kinase (GK) interaction site [polypeptide binding]; other site 326425001816 active site 326425001817 phosphorylation site [posttranslational modification] 326425001818 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326425001819 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 326425001820 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 326425001821 Predicted integral membrane protein [Function unknown]; Region: COG5652 326425001822 hypothetical protein; Validated; Region: PRK00110 326425001823 Type II/IV secretion system protein; Region: T2SE; pfam00437 326425001824 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 326425001825 Walker A motif; other site 326425001826 ATP binding site [chemical binding]; other site 326425001827 Walker B motif; other site 326425001828 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 326425001829 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 326425001830 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 326425001831 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 326425001832 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 326425001833 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 326425001834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326425001835 S-adenosylmethionine binding site [chemical binding]; other site 326425001836 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 326425001837 propionate/acetate kinase; Provisional; Region: PRK12379 326425001838 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 326425001839 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 326425001840 SdpI/YhfL protein family; Region: SdpI; pfam13630 326425001841 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326425001842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326425001843 active site 326425001844 phosphorylation site [posttranslational modification] 326425001845 intermolecular recognition site; other site 326425001846 dimerization interface [polypeptide binding]; other site 326425001847 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326425001848 DNA binding site [nucleotide binding] 326425001849 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326425001850 dimerization interface [polypeptide binding]; other site 326425001851 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326425001852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326425001853 dimer interface [polypeptide binding]; other site 326425001854 phosphorylation site [posttranslational modification] 326425001855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326425001856 ATP binding site [chemical binding]; other site 326425001857 Mg2+ binding site [ion binding]; other site 326425001858 G-X-G motif; other site 326425001859 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 326425001860 Sulfatase; Region: Sulfatase; pfam00884 326425001861 VanZ like family; Region: VanZ; pfam04892 326425001862 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 326425001863 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 326425001864 active site 326425001865 dimer interface [polypeptide binding]; other site 326425001866 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 326425001867 dimer interface [polypeptide binding]; other site 326425001868 active site 326425001869 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 326425001870 Beta-lactamase; Region: Beta-lactamase; pfam00144 326425001871 Virulence-associated protein E; Region: VirE; pfam05272 326425001872 Beta-Casp domain; Region: Beta-Casp; cl12567 326425001873 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 326425001874 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 326425001875 non-specific DNA binding site [nucleotide binding]; other site 326425001876 salt bridge; other site 326425001877 sequence-specific DNA binding site [nucleotide binding]; other site 326425001878 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326425001879 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326425001880 non-specific DNA binding site [nucleotide binding]; other site 326425001881 salt bridge; other site 326425001882 sequence-specific DNA binding site [nucleotide binding]; other site 326425001883 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 326425001884 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 326425001885 Int/Topo IB signature motif; other site 326425001886 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 326425001887 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326425001888 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 326425001889 thymidine kinase; Provisional; Region: PRK04296 326425001890 peptide chain release factor 1; Validated; Region: prfA; PRK00591 326425001891 This domain is found in peptide chain release factors; Region: PCRF; smart00937 326425001892 RF-1 domain; Region: RF-1; pfam00472 326425001893 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 326425001894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326425001895 S-adenosylmethionine binding site [chemical binding]; other site 326425001896 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 326425001897 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 326425001898 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 326425001899 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326425001900 active site 326425001901 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 326425001902 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 326425001903 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 326425001904 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 326425001905 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 326425001906 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 326425001907 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 326425001908 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 326425001909 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 326425001910 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 326425001911 beta subunit interaction interface [polypeptide binding]; other site 326425001912 Walker A motif; other site 326425001913 ATP binding site [chemical binding]; other site 326425001914 Walker B motif; other site 326425001915 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 326425001916 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 326425001917 core domain interface [polypeptide binding]; other site 326425001918 delta subunit interface [polypeptide binding]; other site 326425001919 epsilon subunit interface [polypeptide binding]; other site 326425001920 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 326425001921 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 326425001922 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 326425001923 alpha subunit interaction interface [polypeptide binding]; other site 326425001924 Walker A motif; other site 326425001925 ATP binding site [chemical binding]; other site 326425001926 Walker B motif; other site 326425001927 inhibitor binding site; inhibition site 326425001928 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 326425001929 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 326425001930 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 326425001931 gamma subunit interface [polypeptide binding]; other site 326425001932 epsilon subunit interface [polypeptide binding]; other site 326425001933 LBP interface [polypeptide binding]; other site 326425001934 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 326425001935 rod shape-determining protein MreB; Provisional; Region: PRK13930 326425001936 MreB and similar proteins; Region: MreB_like; cd10225 326425001937 nucleotide binding site [chemical binding]; other site 326425001938 Mg binding site [ion binding]; other site 326425001939 putative protofilament interaction site [polypeptide binding]; other site 326425001940 RodZ interaction site [polypeptide binding]; other site 326425001941 Haemolytic domain; Region: Haemolytic; cl00506 326425001942 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 326425001943 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 326425001944 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 326425001945 Ligand Binding Site [chemical binding]; other site 326425001946 recombination factor protein RarA; Reviewed; Region: PRK13342 326425001947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326425001948 Walker A motif; other site 326425001949 ATP binding site [chemical binding]; other site 326425001950 Walker B motif; other site 326425001951 arginine finger; other site 326425001952 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 326425001953 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 326425001954 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 326425001955 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 326425001956 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326425001957 RNA binding surface [nucleotide binding]; other site 326425001958 septation ring formation regulator EzrA; Provisional; Region: PRK04778 326425001959 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 326425001960 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326425001961 catalytic residue [active] 326425001962 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 326425001963 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 326425001964 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 326425001965 Ligand Binding Site [chemical binding]; other site 326425001966 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326425001967 RNA binding surface [nucleotide binding]; other site 326425001968 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 326425001969 pseudouridine synthase; Region: TIGR00093 326425001970 active site 326425001971 uracil binding [chemical binding]; other site 326425001972 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326425001973 non-specific DNA binding site [nucleotide binding]; other site 326425001974 salt bridge; other site 326425001975 sequence-specific DNA binding site [nucleotide binding]; other site 326425001976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326425001977 salt bridge; other site 326425001978 non-specific DNA binding site [nucleotide binding]; other site 326425001979 sequence-specific DNA binding site [nucleotide binding]; other site 326425001980 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 326425001981 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 326425001982 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 326425001983 active site 326425001984 zinc binding site [ion binding]; other site 326425001985 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 326425001986 Walker A/P-loop; other site 326425001987 ATP binding site [chemical binding]; other site 326425001988 ABC transporter; Region: ABC_tran; pfam00005 326425001989 Q-loop/lid; other site 326425001990 ABC transporter signature motif; other site 326425001991 Walker B; other site 326425001992 D-loop; other site 326425001993 H-loop/switch region; other site 326425001994 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 326425001995 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 326425001996 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 326425001997 Ligand binding site; other site 326425001998 Putative Catalytic site; other site 326425001999 DXD motif; other site 326425002000 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 326425002001 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326425002002 active site 326425002003 HIGH motif; other site 326425002004 nucleotide binding site [chemical binding]; other site 326425002005 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 326425002006 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 326425002007 active site 326425002008 KMSKS motif; other site 326425002009 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 326425002010 tRNA binding surface [nucleotide binding]; other site 326425002011 anticodon binding site; other site 326425002012 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 326425002013 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 326425002014 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326425002015 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 326425002016 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 326425002017 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326425002018 motif II; other site 326425002019 DNA repair protein radc; Region: radc; TIGR00608 326425002020 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 326425002021 MPN+ (JAMM) motif; other site 326425002022 Zinc-binding site [ion binding]; other site 326425002023 rod shape-determining protein MreB; Provisional; Region: PRK13927 326425002024 MreB and similar proteins; Region: MreB_like; cd10225 326425002025 nucleotide binding site [chemical binding]; other site 326425002026 Mg binding site [ion binding]; other site 326425002027 putative protofilament interaction site [polypeptide binding]; other site 326425002028 RodZ interaction site [polypeptide binding]; other site 326425002029 rod shape-determining protein MreC; Provisional; Region: PRK13922 326425002030 rod shape-determining protein MreC; Region: MreC; pfam04085 326425002031 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 326425002032 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 326425002033 cell division protein MraZ; Reviewed; Region: PRK00326 326425002034 MraZ protein; Region: MraZ; pfam02381 326425002035 MraZ protein; Region: MraZ; pfam02381 326425002036 MraW methylase family; Region: Methyltransf_5; pfam01795 326425002037 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 326425002038 Cell division protein FtsL; Region: FtsL; cl11433 326425002039 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 326425002040 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 326425002041 Mg++ binding site [ion binding]; other site 326425002042 putative catalytic motif [active] 326425002043 putative substrate binding site [chemical binding]; other site 326425002044 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 326425002045 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326425002046 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 326425002047 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 326425002048 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 326425002049 active site 326425002050 homodimer interface [polypeptide binding]; other site 326425002051 Cell division protein FtsQ; Region: FtsQ; pfam03799 326425002052 cell division protein FtsA; Region: ftsA; TIGR01174 326425002053 Cell division protein FtsA; Region: FtsA; smart00842 326425002054 Cell division protein FtsA; Region: FtsA; pfam14450 326425002055 cell division protein FtsZ; Validated; Region: PRK09330 326425002056 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 326425002057 nucleotide binding site [chemical binding]; other site 326425002058 SulA interaction site; other site 326425002059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 326425002060 YGGT family; Region: YGGT; pfam02325 326425002061 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 326425002062 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326425002063 RNA binding surface [nucleotide binding]; other site 326425002064 DivIVA protein; Region: DivIVA; pfam05103 326425002065 DivIVA domain; Region: DivI1A_domain; TIGR03544 326425002066 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 326425002067 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 326425002068 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326425002069 active site 326425002070 HIGH motif; other site 326425002071 nucleotide binding site [chemical binding]; other site 326425002072 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 326425002073 active site 326425002074 KMSKS motif; other site 326425002075 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 326425002076 tRNA binding surface [nucleotide binding]; other site 326425002077 anticodon binding site; other site 326425002078 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 326425002079 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 326425002080 DNA-binding site [nucleotide binding]; DNA binding site 326425002081 RNA-binding motif; other site 326425002082 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 326425002083 dimer interface [polypeptide binding]; other site 326425002084 ADP-ribose binding site [chemical binding]; other site 326425002085 active site 326425002086 nudix motif; other site 326425002087 metal binding site [ion binding]; metal-binding site 326425002088 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 326425002089 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 326425002090 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 326425002091 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 326425002092 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326425002093 catalytic residue [active] 326425002094 Putative amino acid metabolism; Region: DUF1831; pfam08866 326425002095 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 326425002096 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 326425002097 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326425002098 catalytic core [active] 326425002099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326425002100 binding surface 326425002101 TPR motif; other site 326425002102 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 326425002103 AAA domain; Region: AAA_30; pfam13604 326425002104 Family description; Region: UvrD_C_2; pfam13538 326425002105 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 326425002106 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 326425002107 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 326425002108 hypothetical protein; Provisional; Region: PRK13667 326425002109 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 326425002110 active site 326425002111 catalytic residues [active] 326425002112 metal binding site [ion binding]; metal-binding site 326425002113 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 326425002114 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 326425002115 G1 box; other site 326425002116 putative GEF interaction site [polypeptide binding]; other site 326425002117 GTP/Mg2+ binding site [chemical binding]; other site 326425002118 Switch I region; other site 326425002119 G2 box; other site 326425002120 G3 box; other site 326425002121 Switch II region; other site 326425002122 G4 box; other site 326425002123 G5 box; other site 326425002124 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 326425002125 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 326425002126 cell division protein FtsW; Region: ftsW; TIGR02614 326425002127 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 326425002128 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 326425002129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326425002130 S-adenosylmethionine binding site [chemical binding]; other site 326425002131 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 326425002132 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 326425002133 active site 326425002134 (T/H)XGH motif; other site 326425002135 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 326425002136 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 326425002137 SLBB domain; Region: SLBB; pfam10531 326425002138 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 326425002139 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 326425002140 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 326425002141 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 326425002142 Competence protein; Region: Competence; pfam03772 326425002143 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 326425002144 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326425002145 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 326425002146 DNA polymerase III, delta subunit; Region: holA; TIGR01128 326425002147 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 326425002148 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 326425002149 16S/18S rRNA binding site [nucleotide binding]; other site 326425002150 S13e-L30e interaction site [polypeptide binding]; other site 326425002151 25S rRNA binding site [nucleotide binding]; other site 326425002152 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 326425002153 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326425002154 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 326425002155 elongation factor Tu; Reviewed; Region: PRK00049 326425002156 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 326425002157 G1 box; other site 326425002158 GEF interaction site [polypeptide binding]; other site 326425002159 GTP/Mg2+ binding site [chemical binding]; other site 326425002160 Switch I region; other site 326425002161 G2 box; other site 326425002162 G3 box; other site 326425002163 Switch II region; other site 326425002164 G4 box; other site 326425002165 G5 box; other site 326425002166 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 326425002167 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 326425002168 Antibiotic Binding Site [chemical binding]; other site 326425002169 trigger factor; Provisional; Region: tig; PRK01490 326425002170 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 326425002171 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 326425002172 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 326425002173 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 326425002174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326425002175 Walker A motif; other site 326425002176 ATP binding site [chemical binding]; other site 326425002177 Walker B motif; other site 326425002178 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 326425002179 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 326425002180 G1 box; other site 326425002181 GTP/Mg2+ binding site [chemical binding]; other site 326425002182 Switch I region; other site 326425002183 G2 box; other site 326425002184 G3 box; other site 326425002185 Switch II region; other site 326425002186 G4 box; other site 326425002187 G5 box; other site 326425002188 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 326425002189 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 326425002190 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 326425002191 aspartate kinase; Reviewed; Region: PRK09034 326425002192 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 326425002193 putative catalytic residues [active] 326425002194 putative nucleotide binding site [chemical binding]; other site 326425002195 putative aspartate binding site [chemical binding]; other site 326425002196 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 326425002197 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 326425002198 diaminopimelate decarboxylase; Region: lysA; TIGR01048 326425002199 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 326425002200 active site 326425002201 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 326425002202 substrate binding site [chemical binding]; other site 326425002203 catalytic residues [active] 326425002204 dimer interface [polypeptide binding]; other site 326425002205 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 326425002206 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 326425002207 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 326425002208 active site 326425002209 trimer interface [polypeptide binding]; other site 326425002210 substrate binding site [chemical binding]; other site 326425002211 CoA binding site [chemical binding]; other site 326425002212 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 326425002213 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 326425002214 metal binding site [ion binding]; metal-binding site 326425002215 putative dimer interface [polypeptide binding]; other site 326425002216 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 326425002217 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 326425002218 dimer interface [polypeptide binding]; other site 326425002219 active site 326425002220 catalytic residue [active] 326425002221 dihydrodipicolinate reductase; Provisional; Region: PRK00048 326425002222 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 326425002223 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 326425002224 aromatic amino acid aminotransferase; Validated; Region: PRK07309 326425002225 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326425002226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326425002227 homodimer interface [polypeptide binding]; other site 326425002228 catalytic residue [active] 326425002229 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 326425002230 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 326425002231 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 326425002232 Beta-lactamase; Region: Beta-lactamase; pfam00144 326425002233 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 326425002234 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 326425002235 nudix motif; other site 326425002236 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 326425002237 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 326425002238 active site 326425002239 dimerization interface [polypeptide binding]; other site 326425002240 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326425002241 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326425002242 active site 326425002243 catalytic tetrad [active] 326425002244 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 326425002245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326425002246 DNA-binding site [nucleotide binding]; DNA binding site 326425002247 UTRA domain; Region: UTRA; pfam07702 326425002248 Isochorismatase family; Region: Isochorismatase; pfam00857 326425002249 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 326425002250 catalytic triad [active] 326425002251 conserved cis-peptide bond; other site 326425002252 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 326425002253 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 326425002254 active site 326425002255 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 326425002256 nudix motif; other site 326425002257 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 326425002258 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 326425002259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326425002260 DNA-binding site [nucleotide binding]; DNA binding site 326425002261 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 326425002262 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 326425002263 beta-galactosidase; Region: BGL; TIGR03356 326425002264 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 326425002265 FMN binding site [chemical binding]; other site 326425002266 dimer interface [polypeptide binding]; other site 326425002267 enolase; Provisional; Region: eno; PRK00077 326425002268 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 326425002269 dimer interface [polypeptide binding]; other site 326425002270 metal binding site [ion binding]; metal-binding site 326425002271 substrate binding pocket [chemical binding]; other site 326425002272 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 326425002273 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 326425002274 active site 326425002275 thymidylate synthase; Region: thym_sym; TIGR03284 326425002276 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 326425002277 dimerization interface [polypeptide binding]; other site 326425002278 active site 326425002279 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 326425002280 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 326425002281 folate binding site [chemical binding]; other site 326425002282 NADP+ binding site [chemical binding]; other site 326425002283 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 326425002284 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326425002285 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326425002286 motif I; other site 326425002287 motif II; other site 326425002288 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 326425002289 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 326425002290 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 326425002291 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 326425002292 Walker A/P-loop; other site 326425002293 ATP binding site [chemical binding]; other site 326425002294 Q-loop/lid; other site 326425002295 ABC transporter signature motif; other site 326425002296 Walker B; other site 326425002297 D-loop; other site 326425002298 H-loop/switch region; other site 326425002299 NIL domain; Region: NIL; pfam09383 326425002300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425002301 dimer interface [polypeptide binding]; other site 326425002302 conserved gate region; other site 326425002303 ABC-ATPase subunit interface; other site 326425002304 fumarate hydratase; Reviewed; Region: fumC; PRK00485 326425002305 Class II fumarases; Region: Fumarase_classII; cd01362 326425002306 active site 326425002307 tetramer interface [polypeptide binding]; other site 326425002308 L-aspartate oxidase; Provisional; Region: PRK06175 326425002309 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 326425002310 Predicted oxidoreductase [General function prediction only]; Region: COG3573 326425002311 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 326425002312 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 326425002313 tetramer (dimer of dimers) interface [polypeptide binding]; other site 326425002314 NAD binding site [chemical binding]; other site 326425002315 dimer interface [polypeptide binding]; other site 326425002316 substrate binding site [chemical binding]; other site 326425002317 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 326425002318 trimer interface [polypeptide binding]; other site 326425002319 active site 326425002320 G bulge; other site 326425002321 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 326425002322 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 326425002323 transmembrane helices; other site 326425002324 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 326425002325 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 326425002326 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326425002327 active site 326425002328 nucleotide binding site [chemical binding]; other site 326425002329 HIGH motif; other site 326425002330 KMSKS motif; other site 326425002331 citrate lyase subunit gamma; Provisional; Region: PRK13253 326425002332 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 326425002333 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 326425002334 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 326425002335 Protein of unknown function (DUF441); Region: DUF441; pfam04284 326425002336 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 326425002337 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326425002338 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326425002339 Walker A/P-loop; other site 326425002340 ATP binding site [chemical binding]; other site 326425002341 Q-loop/lid; other site 326425002342 ABC transporter signature motif; other site 326425002343 Walker B; other site 326425002344 D-loop; other site 326425002345 H-loop/switch region; other site 326425002346 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 326425002347 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326425002348 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326425002349 Walker A/P-loop; other site 326425002350 ATP binding site [chemical binding]; other site 326425002351 Q-loop/lid; other site 326425002352 ABC transporter signature motif; other site 326425002353 Walker B; other site 326425002354 D-loop; other site 326425002355 H-loop/switch region; other site 326425002356 hypothetical protein; Provisional; Region: PRK13661 326425002357 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 326425002358 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 326425002359 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 326425002360 Uncharacterized conserved protein [Function unknown]; Region: COG2966 326425002361 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 326425002362 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 326425002363 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 326425002364 substrate binding site [chemical binding]; other site 326425002365 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 326425002366 putative deacylase active site [active] 326425002367 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 326425002368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326425002369 S-adenosylmethionine binding site [chemical binding]; other site 326425002370 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 326425002371 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326425002372 Zn2+ binding site [ion binding]; other site 326425002373 Mg2+ binding site [ion binding]; other site 326425002374 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 326425002375 synthetase active site [active] 326425002376 NTP binding site [chemical binding]; other site 326425002377 metal binding site [ion binding]; metal-binding site 326425002378 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 326425002379 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 326425002380 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 326425002381 putative active site [active] 326425002382 dimerization interface [polypeptide binding]; other site 326425002383 putative tRNAtyr binding site [nucleotide binding]; other site 326425002384 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 326425002385 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 326425002386 dimer interface [polypeptide binding]; other site 326425002387 motif 1; other site 326425002388 active site 326425002389 motif 2; other site 326425002390 motif 3; other site 326425002391 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 326425002392 anticodon binding site; other site 326425002393 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 326425002394 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 326425002395 dimer interface [polypeptide binding]; other site 326425002396 anticodon binding site; other site 326425002397 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 326425002398 homodimer interface [polypeptide binding]; other site 326425002399 motif 1; other site 326425002400 active site 326425002401 motif 2; other site 326425002402 GAD domain; Region: GAD; pfam02938 326425002403 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 326425002404 active site 326425002405 motif 3; other site 326425002406 aromatic amino acid aminotransferase; Validated; Region: PRK07309 326425002407 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326425002408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326425002409 homodimer interface [polypeptide binding]; other site 326425002410 catalytic residue [active] 326425002411 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 326425002412 Flavoprotein; Region: Flavoprotein; pfam02441 326425002413 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 326425002414 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326425002415 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326425002416 active site 326425002417 catalytic tetrad [active] 326425002418 amino acid transporter; Region: 2A0306; TIGR00909 326425002419 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 326425002420 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 326425002421 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 326425002422 GIY-YIG motif/motif A; other site 326425002423 active site 326425002424 catalytic site [active] 326425002425 putative DNA binding site [nucleotide binding]; other site 326425002426 metal binding site [ion binding]; metal-binding site 326425002427 UvrB/uvrC motif; Region: UVR; pfam02151 326425002428 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 326425002429 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 326425002430 DNA binding site [nucleotide binding] 326425002431 GTPase CgtA; Reviewed; Region: obgE; PRK12297 326425002432 GTP1/OBG; Region: GTP1_OBG; pfam01018 326425002433 Obg GTPase; Region: Obg; cd01898 326425002434 G1 box; other site 326425002435 GTP/Mg2+ binding site [chemical binding]; other site 326425002436 Switch I region; other site 326425002437 G2 box; other site 326425002438 G3 box; other site 326425002439 Switch II region; other site 326425002440 G4 box; other site 326425002441 G5 box; other site 326425002442 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 326425002443 ribonuclease Z; Region: RNase_Z; TIGR02651 326425002444 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 326425002445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326425002446 NAD(P) binding site [chemical binding]; other site 326425002447 active site 326425002448 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 326425002449 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 326425002450 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 326425002451 active site 326425002452 metal binding site [ion binding]; metal-binding site 326425002453 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 326425002454 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 326425002455 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 326425002456 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 326425002457 active site 326425002458 PHP Thumb interface [polypeptide binding]; other site 326425002459 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 326425002460 generic binding surface I; other site 326425002461 generic binding surface II; other site 326425002462 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 326425002463 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 326425002464 active site 326425002465 ADP/pyrophosphate binding site [chemical binding]; other site 326425002466 dimerization interface [polypeptide binding]; other site 326425002467 allosteric effector site; other site 326425002468 fructose-1,6-bisphosphate binding site; other site 326425002469 pyruvate kinase; Provisional; Region: PRK06354 326425002470 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 326425002471 domain interfaces; other site 326425002472 active site 326425002473 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 326425002474 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 326425002475 S1 domain; Region: S1_2; pfam13509 326425002476 MarR family; Region: MarR_2; pfam12802 326425002477 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 326425002478 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 326425002479 active site 326425002480 Int/Topo IB signature motif; other site 326425002481 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326425002482 ScpA/B protein; Region: ScpA_ScpB; cl00598 326425002483 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 326425002484 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 326425002485 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326425002486 RNA binding surface [nucleotide binding]; other site 326425002487 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 326425002488 active site 326425002489 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 326425002490 Predicted membrane protein [Function unknown]; Region: COG3601 326425002491 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326425002492 cytidylate kinase; Provisional; Region: cmk; PRK00023 326425002493 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 326425002494 CMP-binding site; other site 326425002495 The sites determining sugar specificity; other site 326425002496 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 326425002497 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 326425002498 RNA binding site [nucleotide binding]; other site 326425002499 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 326425002500 RNA binding site [nucleotide binding]; other site 326425002501 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 326425002502 RNA binding site [nucleotide binding]; other site 326425002503 GTP-binding protein Der; Reviewed; Region: PRK00093 326425002504 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 326425002505 G1 box; other site 326425002506 GTP/Mg2+ binding site [chemical binding]; other site 326425002507 Switch I region; other site 326425002508 G2 box; other site 326425002509 Switch II region; other site 326425002510 G3 box; other site 326425002511 G4 box; other site 326425002512 G5 box; other site 326425002513 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 326425002514 G1 box; other site 326425002515 GTP/Mg2+ binding site [chemical binding]; other site 326425002516 Switch I region; other site 326425002517 G2 box; other site 326425002518 G3 box; other site 326425002519 Switch II region; other site 326425002520 G4 box; other site 326425002521 G5 box; other site 326425002522 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 326425002523 IHF dimer interface [polypeptide binding]; other site 326425002524 IHF - DNA interface [nucleotide binding]; other site 326425002525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 326425002526 binding surface 326425002527 TPR motif; other site 326425002528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 326425002529 binding surface 326425002530 TPR motif; other site 326425002531 Uncharacterized conserved protein [Function unknown]; Region: COG1284 326425002532 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326425002533 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326425002534 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 326425002535 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 326425002536 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 326425002537 active site 326425002538 NTP binding site [chemical binding]; other site 326425002539 metal binding triad [ion binding]; metal-binding site 326425002540 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 326425002541 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 326425002542 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 326425002543 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 326425002544 EDD domain protein, DegV family; Region: DegV; TIGR00762 326425002545 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 326425002546 hypothetical protein; Provisional; Region: PRK13672 326425002547 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 326425002548 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 326425002549 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 326425002550 GTP/Mg2+ binding site [chemical binding]; other site 326425002551 G4 box; other site 326425002552 G5 box; other site 326425002553 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 326425002554 G1 box; other site 326425002555 G1 box; other site 326425002556 GTP/Mg2+ binding site [chemical binding]; other site 326425002557 Switch I region; other site 326425002558 G2 box; other site 326425002559 G2 box; other site 326425002560 Switch I region; other site 326425002561 G3 box; other site 326425002562 G3 box; other site 326425002563 Switch II region; other site 326425002564 Switch II region; other site 326425002565 G4 box; other site 326425002566 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 326425002567 RNA/DNA hybrid binding site [nucleotide binding]; other site 326425002568 active site 326425002569 DNA protecting protein DprA; Region: dprA; TIGR00732 326425002570 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 326425002571 DNA topoisomerase I; Validated; Region: PRK05582 326425002572 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 326425002573 active site 326425002574 interdomain interaction site; other site 326425002575 putative metal-binding site [ion binding]; other site 326425002576 nucleotide binding site [chemical binding]; other site 326425002577 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 326425002578 domain I; other site 326425002579 DNA binding groove [nucleotide binding] 326425002580 phosphate binding site [ion binding]; other site 326425002581 domain II; other site 326425002582 domain III; other site 326425002583 nucleotide binding site [chemical binding]; other site 326425002584 catalytic site [active] 326425002585 domain IV; other site 326425002586 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 326425002587 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 326425002588 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 326425002589 Glucose inhibited division protein A; Region: GIDA; pfam01134 326425002590 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 326425002591 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326425002592 active site 326425002593 DNA binding site [nucleotide binding] 326425002594 Int/Topo IB signature motif; other site 326425002595 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 326425002596 active site 326425002597 HslU subunit interaction site [polypeptide binding]; other site 326425002598 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 326425002599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326425002600 Walker A motif; other site 326425002601 ATP binding site [chemical binding]; other site 326425002602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 326425002603 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 326425002604 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 326425002605 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326425002606 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 326425002607 camphor resistance protein CrcB; Provisional; Region: PRK14220 326425002608 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326425002609 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 326425002610 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 326425002611 Walker A/P-loop; other site 326425002612 ATP binding site [chemical binding]; other site 326425002613 Q-loop/lid; other site 326425002614 ABC transporter signature motif; other site 326425002615 Walker B; other site 326425002616 D-loop; other site 326425002617 H-loop/switch region; other site 326425002618 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 326425002619 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 326425002620 Presynaptic Site I dimer interface [polypeptide binding]; other site 326425002621 catalytic residues [active] 326425002622 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 326425002623 Synaptic Flat tetramer interface [polypeptide binding]; other site 326425002624 Synaptic Site I dimer interface [polypeptide binding]; other site 326425002625 DNA binding site [nucleotide binding] 326425002626 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 326425002627 DNA-binding interface [nucleotide binding]; DNA binding site 326425002628 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 326425002629 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 326425002630 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326425002631 catalytic residue [active] 326425002632 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 326425002633 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 326425002634 Aluminium resistance protein; Region: Alum_res; pfam06838 326425002635 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 326425002636 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326425002637 ATP binding site [chemical binding]; other site 326425002638 putative Mg++ binding site [ion binding]; other site 326425002639 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326425002640 nucleotide binding region [chemical binding]; other site 326425002641 ATP-binding site [chemical binding]; other site 326425002642 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 326425002643 HRDC domain; Region: HRDC; pfam00570 326425002644 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 326425002645 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 326425002646 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 326425002647 active site 326425002648 maltose O-acetyltransferase; Provisional; Region: PRK10092 326425002649 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 326425002650 active site 326425002651 substrate binding site [chemical binding]; other site 326425002652 trimer interface [polypeptide binding]; other site 326425002653 CoA binding site [chemical binding]; other site 326425002654 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 326425002655 Beta-lactamase; Region: Beta-lactamase; pfam00144 326425002656 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 326425002657 pyridoxal binding site [chemical binding]; other site 326425002658 dimer interface [polypeptide binding]; other site 326425002659 ATP binding site [chemical binding]; other site 326425002660 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 326425002661 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 326425002662 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 326425002663 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 326425002664 peptidase T; Region: peptidase-T; TIGR01882 326425002665 metal binding site [ion binding]; metal-binding site 326425002666 dimer interface [polypeptide binding]; other site 326425002667 Fic/DOC family; Region: Fic; cl00960 326425002668 Fic/DOC family; Region: Fic; cl00960 326425002669 H+ Antiporter protein; Region: 2A0121; TIGR00900 326425002670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326425002671 putative substrate translocation pore; other site 326425002672 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326425002673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326425002674 Coenzyme A binding pocket [chemical binding]; other site 326425002675 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 326425002676 active site 326425002677 catalytic motif [active] 326425002678 Zn binding site [ion binding]; other site 326425002679 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 326425002680 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 326425002681 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 326425002682 nudix motif; other site 326425002683 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 326425002684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 326425002685 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 326425002686 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326425002687 Coenzyme A binding pocket [chemical binding]; other site 326425002688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326425002689 Walker A/P-loop; other site 326425002690 ATP binding site [chemical binding]; other site 326425002691 Q-loop/lid; other site 326425002692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326425002693 ABC transporter signature motif; other site 326425002694 Walker B; other site 326425002695 D-loop; other site 326425002696 H-loop/switch region; other site 326425002697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326425002698 AAA domain; Region: AAA_21; pfam13304 326425002699 Walker A/P-loop; other site 326425002700 ATP binding site [chemical binding]; other site 326425002701 Q-loop/lid; other site 326425002702 ABC transporter signature motif; other site 326425002703 Walker B; other site 326425002704 D-loop; other site 326425002705 H-loop/switch region; other site 326425002706 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 326425002707 putative active site [active] 326425002708 LytTr DNA-binding domain; Region: LytTR; smart00850 326425002709 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 326425002710 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 326425002711 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326425002712 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326425002713 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326425002714 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326425002715 Walker A/P-loop; other site 326425002716 ATP binding site [chemical binding]; other site 326425002717 Q-loop/lid; other site 326425002718 ABC transporter signature motif; other site 326425002719 Walker B; other site 326425002720 D-loop; other site 326425002721 H-loop/switch region; other site 326425002722 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 326425002723 HPr interaction site; other site 326425002724 glycerol kinase (GK) interaction site [polypeptide binding]; other site 326425002725 active site 326425002726 phosphorylation site [posttranslational modification] 326425002727 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 326425002728 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 326425002729 active site turn [active] 326425002730 phosphorylation site [posttranslational modification] 326425002731 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 326425002732 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326425002733 DNA-binding site [nucleotide binding]; DNA binding site 326425002734 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 326425002735 UTRA domain; Region: UTRA; pfam07702 326425002736 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 326425002737 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 326425002738 Ca binding site [ion binding]; other site 326425002739 active site 326425002740 catalytic site [active] 326425002741 SH3-like domain; Region: SH3_8; pfam13457 326425002742 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 326425002743 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 326425002744 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 326425002745 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 326425002746 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 326425002747 TIGR02687 family protein; Region: TIGR02687 326425002748 PglZ domain; Region: PglZ; pfam08665 326425002749 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 326425002750 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 326425002751 catalytic triad [active] 326425002752 putative active site [active] 326425002753 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 326425002754 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 326425002755 Bacterial surface layer protein; Region: SLAP; pfam03217 326425002756 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 326425002757 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326425002758 active site 326425002759 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 326425002760 Archaeal ATPase; Region: Arch_ATPase; pfam01637 326425002761 AAA domain; Region: AAA_14; pfam13173 326425002762 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 326425002763 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 326425002764 HsdM N-terminal domain; Region: HsdM_N; pfam12161 326425002765 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 326425002766 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 326425002767 Uncharacterized conserved protein [Function unknown]; Region: COG1479 326425002768 Protein of unknown function DUF262; Region: DUF262; pfam03235 326425002769 Uncharacterized conserved protein [Function unknown]; Region: COG3472 326425002770 Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565 326425002771 Acetokinase family; Region: Acetate_kinase; cl17229 326425002772 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 326425002773 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 326425002774 active site 326425002775 Zn binding site [ion binding]; other site 326425002776 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 326425002777 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 326425002778 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 326425002779 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 326425002780 metal binding site [ion binding]; metal-binding site 326425002781 dimer interface [polypeptide binding]; other site 326425002782 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 326425002783 AAA ATPase domain; Region: AAA_16; pfam13191 326425002784 Uncharacterized conserved protein [Function unknown]; Region: COG3410 326425002785 TrkA-N domain; Region: TrkA_N; pfam02254 326425002786 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326425002787 active site 326425002788 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 326425002789 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 326425002790 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 326425002791 dipeptidase PepV; Reviewed; Region: PRK07318 326425002792 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 326425002793 active site 326425002794 metal binding site [ion binding]; metal-binding site 326425002795 Beta-lactamase; Region: Beta-lactamase; pfam00144 326425002796 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 326425002797 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 326425002798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326425002799 Coenzyme A binding pocket [chemical binding]; other site 326425002800 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 326425002801 LytTr DNA-binding domain; Region: LytTR; smart00850 326425002802 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 326425002803 endonuclease III; Region: ENDO3c; smart00478 326425002804 minor groove reading motif; other site 326425002805 helix-hairpin-helix signature motif; other site 326425002806 substrate binding pocket [chemical binding]; other site 326425002807 active site 326425002808 Dihydroneopterin aldolase; Region: FolB; pfam02152 326425002809 active site 326425002810 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 326425002811 catalytic center binding site [active] 326425002812 ATP binding site [chemical binding]; other site 326425002813 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 326425002814 GTP cyclohydrolase I; Provisional; Region: PLN03044 326425002815 active site 326425002816 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 326425002817 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326425002818 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 326425002819 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 326425002820 dihydropteroate synthase; Region: DHPS; TIGR01496 326425002821 substrate binding pocket [chemical binding]; other site 326425002822 dimer interface [polypeptide binding]; other site 326425002823 inhibitor binding site; inhibition site 326425002824 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 326425002825 nudix motif; other site 326425002826 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 326425002827 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 326425002828 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 326425002829 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326425002830 DNA binding residues [nucleotide binding] 326425002831 putative dimer interface [polypeptide binding]; other site 326425002832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425002833 dimer interface [polypeptide binding]; other site 326425002834 conserved gate region; other site 326425002835 putative PBP binding loops; other site 326425002836 ABC-ATPase subunit interface; other site 326425002837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425002838 dimer interface [polypeptide binding]; other site 326425002839 conserved gate region; other site 326425002840 putative PBP binding loops; other site 326425002841 ABC-ATPase subunit interface; other site 326425002842 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326425002843 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 326425002844 Walker A/P-loop; other site 326425002845 ATP binding site [chemical binding]; other site 326425002846 Q-loop/lid; other site 326425002847 ABC transporter signature motif; other site 326425002848 Walker B; other site 326425002849 D-loop; other site 326425002850 H-loop/switch region; other site 326425002851 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 326425002852 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326425002853 substrate binding pocket [chemical binding]; other site 326425002854 membrane-bound complex binding site; other site 326425002855 hinge residues; other site 326425002856 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326425002857 active site 326425002858 DNA binding site [nucleotide binding] 326425002859 Int/Topo IB signature motif; other site 326425002860 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 326425002861 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326425002862 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326425002863 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 326425002864 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 326425002865 dimer interface [polypeptide binding]; other site 326425002866 FMN binding site [chemical binding]; other site 326425002867 NADPH bind site [chemical binding]; other site 326425002868 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 326425002869 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326425002870 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326425002871 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 326425002872 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 326425002873 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 326425002874 dimerization interface [polypeptide binding]; other site 326425002875 DPS ferroxidase diiron center [ion binding]; other site 326425002876 ion pore; other site 326425002877 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 326425002878 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 326425002879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326425002880 Mg2+ binding site [ion binding]; other site 326425002881 G-X-G motif; other site 326425002882 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 326425002883 anchoring element; other site 326425002884 dimer interface [polypeptide binding]; other site 326425002885 ATP binding site [chemical binding]; other site 326425002886 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 326425002887 active site 326425002888 putative metal-binding site [ion binding]; other site 326425002889 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 326425002890 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 326425002891 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 326425002892 CAP-like domain; other site 326425002893 active site 326425002894 primary dimer interface [polypeptide binding]; other site 326425002895 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326425002896 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326425002897 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326425002898 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 326425002899 dimerization interface [polypeptide binding]; other site 326425002900 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 326425002901 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 326425002902 DHHA2 domain; Region: DHHA2; pfam02833 326425002903 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 326425002904 active site 326425002905 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326425002906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326425002907 non-specific DNA binding site [nucleotide binding]; other site 326425002908 salt bridge; other site 326425002909 sequence-specific DNA binding site [nucleotide binding]; other site 326425002910 GDA1/CD39 (nucleoside phosphatase) family; Region: GDA1_CD39; cl17763 326425002911 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 326425002912 Predicted membrane protein [Function unknown]; Region: COG2261 326425002913 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 326425002914 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326425002915 active site 326425002916 DNA binding site [nucleotide binding] 326425002917 Int/Topo IB signature motif; other site 326425002918 EDD domain protein, DegV family; Region: DegV; TIGR00762 326425002919 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 326425002920 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326425002921 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 326425002922 Domain of unknown function (DUF814); Region: DUF814; pfam05670 326425002923 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 326425002924 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326425002925 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326425002926 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 326425002927 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326425002928 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 326425002929 IMP binding site; other site 326425002930 dimer interface [polypeptide binding]; other site 326425002931 interdomain contacts; other site 326425002932 partial ornithine binding site; other site 326425002933 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 326425002934 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 326425002935 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 326425002936 catalytic site [active] 326425002937 subunit interface [polypeptide binding]; other site 326425002938 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 326425002939 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326425002940 RNA binding surface [nucleotide binding]; other site 326425002941 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 326425002942 active site 326425002943 lipoprotein signal peptidase; Provisional; Region: PRK14797 326425002944 lipoprotein signal peptidase; Provisional; Region: PRK14787 326425002945 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 326425002946 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 326425002947 Potassium binding sites [ion binding]; other site 326425002948 Cesium cation binding sites [ion binding]; other site 326425002949 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 326425002950 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 326425002951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326425002952 DivIVA protein; Region: DivIVA; pfam05103 326425002953 DivIVA domain; Region: DivI1A_domain; TIGR03544 326425002954 hypothetical protein; Provisional; Region: PRK13660 326425002955 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 326425002956 Transglycosylase; Region: Transgly; pfam00912 326425002957 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 326425002958 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 326425002959 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 326425002960 endonuclease III; Region: ENDO3c; smart00478 326425002961 minor groove reading motif; other site 326425002962 helix-hairpin-helix signature motif; other site 326425002963 substrate binding pocket [chemical binding]; other site 326425002964 active site 326425002965 Helix-turn-helix domain; Region: HTH_36; pfam13730 326425002966 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 326425002967 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 326425002968 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 326425002969 putative dimer interface [polypeptide binding]; other site 326425002970 putative anticodon binding site; other site 326425002971 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 326425002972 homodimer interface [polypeptide binding]; other site 326425002973 motif 1; other site 326425002974 motif 2; other site 326425002975 active site 326425002976 motif 3; other site 326425002977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 326425002978 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 326425002979 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 326425002980 active site 326425002981 catalytic site [active] 326425002982 substrate binding site [chemical binding]; other site 326425002983 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 326425002984 ATP binding site [chemical binding]; other site 326425002985 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 326425002986 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 326425002987 Part of AAA domain; Region: AAA_19; pfam13245 326425002988 Family description; Region: UvrD_C_2; pfam13538 326425002989 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 326425002990 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 326425002991 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 326425002992 mevalonate kinase; Region: mevalon_kin; TIGR00549 326425002993 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 326425002994 diphosphomevalonate decarboxylase; Region: PLN02407 326425002995 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 326425002996 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 326425002997 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 326425002998 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 326425002999 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 326425003000 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 326425003001 homotetramer interface [polypeptide binding]; other site 326425003002 FMN binding site [chemical binding]; other site 326425003003 homodimer contacts [polypeptide binding]; other site 326425003004 putative active site [active] 326425003005 putative substrate binding site [chemical binding]; other site 326425003006 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 326425003007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326425003008 S-adenosylmethionine binding site [chemical binding]; other site 326425003009 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 326425003010 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 326425003011 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 326425003012 Catalytic site [active] 326425003013 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 326425003014 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 326425003015 Walker A/P-loop; other site 326425003016 ATP binding site [chemical binding]; other site 326425003017 Q-loop/lid; other site 326425003018 ABC transporter signature motif; other site 326425003019 Walker B; other site 326425003020 D-loop; other site 326425003021 H-loop/switch region; other site 326425003022 Predicted transcriptional regulators [Transcription]; Region: COG1725 326425003023 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326425003024 DNA-binding site [nucleotide binding]; DNA binding site 326425003025 peptidase T; Region: peptidase-T; TIGR01882 326425003026 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 326425003027 metal binding site [ion binding]; metal-binding site 326425003028 dimer interface [polypeptide binding]; other site 326425003029 Uncharacterized conserved protein [Function unknown]; Region: COG0327 326425003030 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 326425003031 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 326425003032 Family of unknown function (DUF633); Region: DUF633; pfam04816 326425003033 Peptidase family M23; Region: Peptidase_M23; pfam01551 326425003034 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 326425003035 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 326425003036 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326425003037 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 326425003038 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326425003039 DNA binding residues [nucleotide binding] 326425003040 DNA primase; Validated; Region: dnaG; PRK05667 326425003041 CHC2 zinc finger; Region: zf-CHC2; cl17510 326425003042 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 326425003043 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 326425003044 active site 326425003045 metal binding site [ion binding]; metal-binding site 326425003046 interdomain interaction site; other site 326425003047 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 326425003048 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 326425003049 DALR anticodon binding domain; Region: DALR_1; pfam05746 326425003050 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 326425003051 motif 1; other site 326425003052 dimer interface [polypeptide binding]; other site 326425003053 active site 326425003054 motif 2; other site 326425003055 motif 3; other site 326425003056 Recombination protein O N terminal; Region: RecO_N; pfam11967 326425003057 DNA repair protein RecO; Region: reco; TIGR00613 326425003058 Recombination protein O C terminal; Region: RecO_C; pfam02565 326425003059 GTPase Era; Reviewed; Region: era; PRK00089 326425003060 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 326425003061 G1 box; other site 326425003062 GTP/Mg2+ binding site [chemical binding]; other site 326425003063 Switch I region; other site 326425003064 G2 box; other site 326425003065 Switch II region; other site 326425003066 G3 box; other site 326425003067 G4 box; other site 326425003068 G5 box; other site 326425003069 metal-binding heat shock protein; Provisional; Region: PRK00016 326425003070 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 326425003071 PhoH-like protein; Region: PhoH; pfam02562 326425003072 Yqey-like protein; Region: YqeY; pfam09424 326425003073 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 326425003074 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 326425003075 Peptidase family M23; Region: Peptidase_M23; pfam01551 326425003076 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 326425003077 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 326425003078 active site 326425003079 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 326425003080 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 326425003081 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 326425003082 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 326425003083 tape measure domain; Region: tape_meas_nterm; TIGR02675 326425003084 Phage XkdN-like protein; Region: XkdN; pfam08890 326425003085 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 326425003086 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 326425003087 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 326425003088 LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cl06998 326425003089 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 326425003090 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 326425003091 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 326425003092 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 326425003093 Phage terminase large subunit; Region: Terminase_3; cl12054 326425003094 Terminase-like family; Region: Terminase_6; pfam03237 326425003095 Terminase small subunit; Region: Terminase_2; pfam03592 326425003096 VRR-NUC domain; Region: VRR_NUC; pfam08774 326425003097 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 326425003098 Virulence-associated protein E; Region: VirE; pfam05272 326425003099 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 326425003100 polymerase nucleotide-binding site; other site 326425003101 DNA-binding residues [nucleotide binding]; DNA binding site 326425003102 nucleotide binding site [chemical binding]; other site 326425003103 primase nucleotide-binding site [nucleotide binding]; other site 326425003104 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 326425003105 AAA domain; Region: AAA_24; pfam13479 326425003106 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 326425003107 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 326425003108 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 326425003109 putative Mg++ binding site [ion binding]; other site 326425003110 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326425003111 nucleotide binding region [chemical binding]; other site 326425003112 ATP-binding site [chemical binding]; other site 326425003113 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 326425003114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 326425003115 non-specific DNA binding site [nucleotide binding]; other site 326425003116 salt bridge; other site 326425003117 sequence-specific DNA binding site [nucleotide binding]; other site 326425003118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326425003119 non-specific DNA binding site [nucleotide binding]; other site 326425003120 salt bridge; other site 326425003121 sequence-specific DNA binding site [nucleotide binding]; other site 326425003122 Peptidase family M48; Region: Peptidase_M48; cl12018 326425003123 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 326425003124 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 326425003125 Int/Topo IB signature motif; other site 326425003126 Uncharacterized conserved protein [Function unknown]; Region: COG1284 326425003127 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326425003128 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326425003129 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 326425003130 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 326425003131 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326425003132 dimerization interface [polypeptide binding]; other site 326425003133 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 326425003134 Sterol carrier protein domain; Region: SCP2_2; pfam13530 326425003135 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 326425003136 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326425003137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326425003138 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 326425003139 dimerization interface [polypeptide binding]; other site 326425003140 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 326425003141 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 326425003142 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326425003143 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326425003144 motif II; other site 326425003145 Bacterial surface layer protein; Region: SLAP; pfam03217 326425003146 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 326425003147 conserved cys residue [active] 326425003148 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326425003149 active site 326425003150 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 326425003151 DHH family; Region: DHH; pfam01368 326425003152 DHHA1 domain; Region: DHHA1; pfam02272 326425003153 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 326425003154 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 326425003155 active site 326425003156 catalytic site [active] 326425003157 GTP-binding protein LepA; Provisional; Region: PRK05433 326425003158 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 326425003159 G1 box; other site 326425003160 putative GEF interaction site [polypeptide binding]; other site 326425003161 GTP/Mg2+ binding site [chemical binding]; other site 326425003162 Switch I region; other site 326425003163 G2 box; other site 326425003164 G3 box; other site 326425003165 Switch II region; other site 326425003166 G4 box; other site 326425003167 G5 box; other site 326425003168 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 326425003169 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 326425003170 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 326425003171 chaperone protein DnaJ; Provisional; Region: PRK14276 326425003172 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 326425003173 HSP70 interaction site [polypeptide binding]; other site 326425003174 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 326425003175 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 326425003176 dimer interface [polypeptide binding]; other site 326425003177 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 326425003178 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 326425003179 nucleotide binding site [chemical binding]; other site 326425003180 NEF interaction site [polypeptide binding]; other site 326425003181 SBD interface [polypeptide binding]; other site 326425003182 GrpE; Region: GrpE; pfam01025 326425003183 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 326425003184 dimer interface [polypeptide binding]; other site 326425003185 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 326425003186 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 326425003187 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 326425003188 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 326425003189 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 326425003190 active site 326425003191 Riboflavin kinase; Region: Flavokinase; pfam01687 326425003192 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 326425003193 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 326425003194 RNA binding site [nucleotide binding]; other site 326425003195 active site 326425003196 ribosome-binding factor A; Provisional; Region: PRK13818 326425003197 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 326425003198 translation initiation factor IF-2; Region: IF-2; TIGR00487 326425003199 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 326425003200 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 326425003201 G1 box; other site 326425003202 putative GEF interaction site [polypeptide binding]; other site 326425003203 GTP/Mg2+ binding site [chemical binding]; other site 326425003204 Switch I region; other site 326425003205 G2 box; other site 326425003206 G3 box; other site 326425003207 Switch II region; other site 326425003208 G4 box; other site 326425003209 G5 box; other site 326425003210 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 326425003211 Translation-initiation factor 2; Region: IF-2; pfam11987 326425003212 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 326425003213 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 326425003214 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 326425003215 putative RNA binding cleft [nucleotide binding]; other site 326425003216 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 326425003217 NusA N-terminal domain; Region: NusA_N; pfam08529 326425003218 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 326425003219 RNA binding site [nucleotide binding]; other site 326425003220 homodimer interface [polypeptide binding]; other site 326425003221 NusA-like KH domain; Region: KH_5; pfam13184 326425003222 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 326425003223 G-X-X-G motif; other site 326425003224 ribosome maturation protein RimP; Reviewed; Region: PRK00092 326425003225 Sm and related proteins; Region: Sm_like; cl00259 326425003226 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 326425003227 putative oligomer interface [polypeptide binding]; other site 326425003228 putative RNA binding site [nucleotide binding]; other site 326425003229 DNA polymerase III PolC; Validated; Region: polC; PRK00448 326425003230 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 326425003231 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 326425003232 generic binding surface II; other site 326425003233 generic binding surface I; other site 326425003234 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 326425003235 active site 326425003236 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 326425003237 active site 326425003238 catalytic site [active] 326425003239 substrate binding site [chemical binding]; other site 326425003240 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 326425003241 prolyl-tRNA synthetase; Provisional; Region: PRK09194 326425003242 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 326425003243 dimer interface [polypeptide binding]; other site 326425003244 motif 1; other site 326425003245 active site 326425003246 motif 2; other site 326425003247 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 326425003248 putative deacylase active site [active] 326425003249 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 326425003250 active site 326425003251 motif 3; other site 326425003252 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 326425003253 anticodon binding site; other site 326425003254 RIP metalloprotease RseP; Region: TIGR00054 326425003255 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 326425003256 active site 326425003257 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 326425003258 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 326425003259 protein binding site [polypeptide binding]; other site 326425003260 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 326425003261 putative substrate binding region [chemical binding]; other site 326425003262 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 326425003263 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 326425003264 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 326425003265 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 326425003266 catalytic residue [active] 326425003267 putative FPP diphosphate binding site; other site 326425003268 putative FPP binding hydrophobic cleft; other site 326425003269 dimer interface [polypeptide binding]; other site 326425003270 putative IPP diphosphate binding site; other site 326425003271 ribosome recycling factor; Reviewed; Region: frr; PRK00083 326425003272 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 326425003273 hinge region; other site 326425003274 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 326425003275 putative nucleotide binding site [chemical binding]; other site 326425003276 uridine monophosphate binding site [chemical binding]; other site 326425003277 homohexameric interface [polypeptide binding]; other site 326425003278 elongation factor Ts; Provisional; Region: tsf; PRK09377 326425003279 UBA/TS-N domain; Region: UBA; pfam00627 326425003280 Elongation factor TS; Region: EF_TS; pfam00889 326425003281 Elongation factor TS; Region: EF_TS; pfam00889 326425003282 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 326425003283 rRNA interaction site [nucleotide binding]; other site 326425003284 S8 interaction site; other site 326425003285 putative laminin-1 binding site; other site 326425003286 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 326425003287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326425003288 S-adenosylmethionine binding site [chemical binding]; other site 326425003289 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 326425003290 GIY-YIG motif/motif A; other site 326425003291 putative active site [active] 326425003292 putative metal binding site [ion binding]; other site 326425003293 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 326425003294 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 326425003295 putative acyl-acceptor binding pocket; other site 326425003296 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 326425003297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326425003298 S-adenosylmethionine binding site [chemical binding]; other site 326425003299 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 326425003300 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 326425003301 active site 326425003302 Zn binding site [ion binding]; other site 326425003303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 326425003304 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 326425003305 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326425003306 putative DNA binding site [nucleotide binding]; other site 326425003307 LexA repressor; Validated; Region: PRK00215 326425003308 putative Zn2+ binding site [ion binding]; other site 326425003309 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 326425003310 Catalytic site [active] 326425003311 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 326425003312 active site 326425003313 catalytic triad [active] 326425003314 oxyanion hole [active] 326425003315 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 326425003316 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 326425003317 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 326425003318 RimM N-terminal domain; Region: RimM; pfam01782 326425003319 PRC-barrel domain; Region: PRC; pfam05239 326425003320 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 326425003321 signal recognition particle protein; Provisional; Region: PRK10867 326425003322 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 326425003323 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 326425003324 P loop; other site 326425003325 GTP binding site [chemical binding]; other site 326425003326 Signal peptide binding domain; Region: SRP_SPB; pfam02978 326425003327 putative DNA-binding protein; Validated; Region: PRK00118 326425003328 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 326425003329 amino acid transporter; Region: 2A0306; TIGR00909 326425003330 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 326425003331 Peptidase family C69; Region: Peptidase_C69; pfam03577 326425003332 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 326425003333 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 326425003334 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 326425003335 P loop; other site 326425003336 GTP binding site [chemical binding]; other site 326425003337 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 326425003338 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 326425003339 Walker A/P-loop; other site 326425003340 ATP binding site [chemical binding]; other site 326425003341 Q-loop/lid; other site 326425003342 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 326425003343 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 326425003344 ABC transporter signature motif; other site 326425003345 Walker B; other site 326425003346 D-loop; other site 326425003347 H-loop/switch region; other site 326425003348 ribonuclease III; Reviewed; Region: rnc; PRK00102 326425003349 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 326425003350 dimerization interface [polypeptide binding]; other site 326425003351 active site 326425003352 metal binding site [ion binding]; metal-binding site 326425003353 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 326425003354 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 326425003355 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 326425003356 peptide binding site [polypeptide binding]; other site 326425003357 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 326425003358 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 326425003359 peptide binding site [polypeptide binding]; other site 326425003360 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 326425003361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425003362 dimer interface [polypeptide binding]; other site 326425003363 conserved gate region; other site 326425003364 putative PBP binding loops; other site 326425003365 ABC-ATPase subunit interface; other site 326425003366 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 326425003367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425003368 dimer interface [polypeptide binding]; other site 326425003369 conserved gate region; other site 326425003370 putative PBP binding loops; other site 326425003371 ABC-ATPase subunit interface; other site 326425003372 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326425003373 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 326425003374 Walker A/P-loop; other site 326425003375 ATP binding site [chemical binding]; other site 326425003376 Q-loop/lid; other site 326425003377 ABC transporter signature motif; other site 326425003378 Walker B; other site 326425003379 D-loop; other site 326425003380 H-loop/switch region; other site 326425003381 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326425003382 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 326425003383 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326425003384 Walker A/P-loop; other site 326425003385 ATP binding site [chemical binding]; other site 326425003386 Q-loop/lid; other site 326425003387 ABC transporter signature motif; other site 326425003388 Walker B; other site 326425003389 D-loop; other site 326425003390 H-loop/switch region; other site 326425003391 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326425003392 acyl carrier protein; Provisional; Region: acpP; PRK00982 326425003393 putative phosphate acyltransferase; Provisional; Region: PRK05331 326425003394 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 326425003395 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 326425003396 ssDNA binding site; other site 326425003397 generic binding surface II; other site 326425003398 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326425003399 ATP binding site [chemical binding]; other site 326425003400 putative Mg++ binding site [ion binding]; other site 326425003401 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326425003402 nucleotide binding region [chemical binding]; other site 326425003403 ATP-binding site [chemical binding]; other site 326425003404 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 326425003405 DAK2 domain; Region: Dak2; pfam02734 326425003406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 326425003407 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 326425003408 SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins...; Region: SOCS; cl02533 326425003409 Thiamine pyrophosphokinase; Region: TPK; cd07995 326425003410 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 326425003411 active site 326425003412 dimerization interface [polypeptide binding]; other site 326425003413 thiamine binding site [chemical binding]; other site 326425003414 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 326425003415 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 326425003416 substrate binding site [chemical binding]; other site 326425003417 hexamer interface [polypeptide binding]; other site 326425003418 metal binding site [ion binding]; metal-binding site 326425003419 GTPase RsgA; Reviewed; Region: PRK00098 326425003420 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 326425003421 RNA binding site [nucleotide binding]; other site 326425003422 homodimer interface [polypeptide binding]; other site 326425003423 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 326425003424 GTPase/Zn-binding domain interface [polypeptide binding]; other site 326425003425 GTP/Mg2+ binding site [chemical binding]; other site 326425003426 G4 box; other site 326425003427 G5 box; other site 326425003428 G1 box; other site 326425003429 Switch I region; other site 326425003430 G2 box; other site 326425003431 G3 box; other site 326425003432 Switch II region; other site 326425003433 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326425003434 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326425003435 active site 326425003436 ATP binding site [chemical binding]; other site 326425003437 substrate binding site [chemical binding]; other site 326425003438 activation loop (A-loop); other site 326425003439 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326425003440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 326425003441 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326425003442 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326425003443 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326425003444 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 326425003445 Protein phosphatase 2C; Region: PP2C; pfam00481 326425003446 active site 326425003447 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 326425003448 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 326425003449 putative active site [active] 326425003450 substrate binding site [chemical binding]; other site 326425003451 putative cosubstrate binding site; other site 326425003452 catalytic site [active] 326425003453 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 326425003454 substrate binding site [chemical binding]; other site 326425003455 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 326425003456 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326425003457 ATP binding site [chemical binding]; other site 326425003458 putative Mg++ binding site [ion binding]; other site 326425003459 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326425003460 nucleotide binding region [chemical binding]; other site 326425003461 ATP-binding site [chemical binding]; other site 326425003462 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 326425003463 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 326425003464 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 326425003465 catalytic site [active] 326425003466 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 326425003467 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 326425003468 Walker A/P-loop; other site 326425003469 ATP binding site [chemical binding]; other site 326425003470 Q-loop/lid; other site 326425003471 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 326425003472 ABC transporter signature motif; other site 326425003473 Walker B; other site 326425003474 D-loop; other site 326425003475 H-loop/switch region; other site 326425003476 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 326425003477 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326425003478 RNA binding surface [nucleotide binding]; other site 326425003479 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 326425003480 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 326425003481 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 326425003482 substrate binding pocket [chemical binding]; other site 326425003483 chain length determination region; other site 326425003484 substrate-Mg2+ binding site; other site 326425003485 catalytic residues [active] 326425003486 aspartate-rich region 1; other site 326425003487 active site lid residues [active] 326425003488 aspartate-rich region 2; other site 326425003489 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 326425003490 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 326425003491 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 326425003492 generic binding surface II; other site 326425003493 generic binding surface I; other site 326425003494 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 326425003495 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 326425003496 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 326425003497 homodimer interface [polypeptide binding]; other site 326425003498 NADP binding site [chemical binding]; other site 326425003499 substrate binding site [chemical binding]; other site 326425003500 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 326425003501 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 326425003502 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 326425003503 homodimer interface [polypeptide binding]; other site 326425003504 NADP binding site [chemical binding]; other site 326425003505 substrate binding site [chemical binding]; other site 326425003506 transcription antitermination factor NusB; Region: nusB; TIGR01951 326425003507 putative RNA binding site [nucleotide binding]; other site 326425003508 Asp23 family; Region: Asp23; pfam03780 326425003509 elongation factor P; Validated; Region: PRK00529 326425003510 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 326425003511 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 326425003512 RNA binding site [nucleotide binding]; other site 326425003513 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 326425003514 RNA binding site [nucleotide binding]; other site 326425003515 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 326425003516 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 326425003517 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 326425003518 active site 326425003519 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 326425003520 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 326425003521 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 326425003522 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 326425003523 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 326425003524 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 326425003525 homodimer interface [polypeptide binding]; other site 326425003526 substrate-cofactor binding pocket; other site 326425003527 catalytic residue [active] 326425003528 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 326425003529 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 326425003530 active site 1 [active] 326425003531 dimer interface [polypeptide binding]; other site 326425003532 hexamer interface [polypeptide binding]; other site 326425003533 active site 2 [active] 326425003534 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 326425003535 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 326425003536 substrate binding pocket [chemical binding]; other site 326425003537 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 326425003538 ArsC family; Region: ArsC; pfam03960 326425003539 putative ArsC-like catalytic residues; other site 326425003540 putative TRX-like catalytic residues [active] 326425003541 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 326425003542 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 326425003543 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 326425003544 methionine sulfoxide reductase B; Provisional; Region: PRK00222 326425003545 Sugar transport protein; Region: Sugar_transport; pfam06800 326425003546 EamA-like transporter family; Region: EamA; cl17759 326425003547 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 326425003548 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326425003549 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 326425003550 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 326425003551 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326425003552 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326425003553 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 326425003554 IMP binding site; other site 326425003555 dimer interface [polypeptide binding]; other site 326425003556 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 326425003557 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 326425003558 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 326425003559 catalytic site [active] 326425003560 subunit interface [polypeptide binding]; other site 326425003561 dihydroorotase; Validated; Region: pyrC; PRK09357 326425003562 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326425003563 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 326425003564 active site 326425003565 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 326425003566 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 326425003567 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 326425003568 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 326425003569 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326425003570 active site 326425003571 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 326425003572 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 326425003573 heterodimer interface [polypeptide binding]; other site 326425003574 active site 326425003575 FMN binding site [chemical binding]; other site 326425003576 homodimer interface [polypeptide binding]; other site 326425003577 substrate binding site [chemical binding]; other site 326425003578 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 326425003579 active site 326425003580 dimer interface [polypeptide binding]; other site 326425003581 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326425003582 active site 326425003583 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 326425003584 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 326425003585 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326425003586 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 326425003587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326425003588 motif II; other site 326425003589 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 326425003590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326425003591 putative substrate translocation pore; other site 326425003592 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326425003593 MucBP domain; Region: MucBP; pfam06458 326425003594 MucBP domain; Region: MucBP; pfam06458 326425003595 MucBP domain; Region: MucBP; pfam06458 326425003596 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 326425003597 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 326425003598 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326425003599 substrate binding pocket [chemical binding]; other site 326425003600 membrane-bound complex binding site; other site 326425003601 hinge residues; other site 326425003602 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326425003603 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 326425003604 Walker A/P-loop; other site 326425003605 ATP binding site [chemical binding]; other site 326425003606 Q-loop/lid; other site 326425003607 ABC transporter signature motif; other site 326425003608 Walker B; other site 326425003609 D-loop; other site 326425003610 H-loop/switch region; other site 326425003611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425003612 dimer interface [polypeptide binding]; other site 326425003613 conserved gate region; other site 326425003614 putative PBP binding loops; other site 326425003615 ABC-ATPase subunit interface; other site 326425003616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425003617 dimer interface [polypeptide binding]; other site 326425003618 conserved gate region; other site 326425003619 putative PBP binding loops; other site 326425003620 ABC-ATPase subunit interface; other site 326425003621 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 326425003622 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 326425003623 peptide binding site [polypeptide binding]; other site 326425003624 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326425003625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326425003626 putative substrate translocation pore; other site 326425003627 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 326425003628 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 326425003629 putative ligand binding site [chemical binding]; other site 326425003630 putative NAD binding site [chemical binding]; other site 326425003631 putative catalytic site [active] 326425003632 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 326425003633 L-serine binding site [chemical binding]; other site 326425003634 ACT domain interface; other site 326425003635 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 326425003636 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326425003637 catalytic residue [active] 326425003638 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326425003639 catalytic core [active] 326425003640 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 326425003641 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 326425003642 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 326425003643 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 326425003644 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326425003645 active site 326425003646 catalytic tetrad [active] 326425003647 OsmC-like protein; Region: OsmC; pfam02566 326425003648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326425003649 putative substrate translocation pore; other site 326425003650 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326425003651 Bacterial surface layer protein; Region: SLAP; pfam03217 326425003652 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 326425003653 active site 326425003654 catalytic residues [active] 326425003655 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 326425003656 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 326425003657 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 326425003658 galactokinase; Provisional; Region: PRK05322 326425003659 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 326425003660 benzoate transport; Region: 2A0115; TIGR00895 326425003661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326425003662 putative substrate translocation pore; other site 326425003663 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 326425003664 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 326425003665 ligand binding site [chemical binding]; other site 326425003666 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 326425003667 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 326425003668 Walker A/P-loop; other site 326425003669 ATP binding site [chemical binding]; other site 326425003670 Q-loop/lid; other site 326425003671 ABC transporter signature motif; other site 326425003672 Walker B; other site 326425003673 D-loop; other site 326425003674 H-loop/switch region; other site 326425003675 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 326425003676 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 326425003677 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 326425003678 TM-ABC transporter signature motif; other site 326425003679 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 326425003680 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 326425003681 TM-ABC transporter signature motif; other site 326425003682 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 326425003683 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 326425003684 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 326425003685 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 326425003686 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 326425003687 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 326425003688 active site 326425003689 substrate binding site [chemical binding]; other site 326425003690 cosubstrate binding site; other site 326425003691 catalytic site [active] 326425003692 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 326425003693 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 326425003694 purine monophosphate binding site [chemical binding]; other site 326425003695 dimer interface [polypeptide binding]; other site 326425003696 putative catalytic residues [active] 326425003697 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 326425003698 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 326425003699 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 326425003700 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 326425003701 dimerization interface [polypeptide binding]; other site 326425003702 putative ATP binding site [chemical binding]; other site 326425003703 amidophosphoribosyltransferase; Provisional; Region: PRK07272 326425003704 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 326425003705 active site 326425003706 tetramer interface [polypeptide binding]; other site 326425003707 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326425003708 active site 326425003709 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 326425003710 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 326425003711 dimerization interface [polypeptide binding]; other site 326425003712 ATP binding site [chemical binding]; other site 326425003713 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 326425003714 dimerization interface [polypeptide binding]; other site 326425003715 ATP binding site [chemical binding]; other site 326425003716 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 326425003717 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 326425003718 putative active site [active] 326425003719 catalytic triad [active] 326425003720 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 326425003721 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 326425003722 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 326425003723 ATP binding site [chemical binding]; other site 326425003724 active site 326425003725 substrate binding site [chemical binding]; other site 326425003726 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 326425003727 ATP-grasp domain; Region: ATP-grasp; pfam02222 326425003728 AIR carboxylase; Region: AIRC; pfam00731 326425003729 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 326425003730 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 326425003731 Potassium binding sites [ion binding]; other site 326425003732 Cesium cation binding sites [ion binding]; other site 326425003733 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 326425003734 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 326425003735 active site 326425003736 catalytic residue [active] 326425003737 dimer interface [polypeptide binding]; other site 326425003738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326425003739 putative substrate translocation pore; other site 326425003740 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326425003741 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 326425003742 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 326425003743 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 326425003744 shikimate binding site; other site 326425003745 NAD(P) binding site [chemical binding]; other site 326425003746 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 326425003747 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 326425003748 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 326425003749 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 326425003750 HPr interaction site; other site 326425003751 glycerol kinase (GK) interaction site [polypeptide binding]; other site 326425003752 active site 326425003753 phosphorylation site [posttranslational modification] 326425003754 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326425003755 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326425003756 DNA binding site [nucleotide binding] 326425003757 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 326425003758 putative dimerization interface [polypeptide binding]; other site 326425003759 putative ligand binding site [chemical binding]; other site 326425003760 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 326425003761 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 326425003762 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 326425003763 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 326425003764 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 326425003765 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 326425003766 NAD binding site [chemical binding]; other site 326425003767 homodimer interface [polypeptide binding]; other site 326425003768 active site 326425003769 substrate binding site [chemical binding]; other site 326425003770 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 326425003771 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 326425003772 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 326425003773 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 326425003774 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 326425003775 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 326425003776 active site residue [active] 326425003777 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 326425003778 Rhomboid family; Region: Rhomboid; pfam01694 326425003779 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 326425003780 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 326425003781 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 326425003782 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 326425003783 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 326425003784 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 326425003785 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 326425003786 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 326425003787 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 326425003788 nucleotide binding site [chemical binding]; other site 326425003789 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326425003790 non-specific DNA binding site [nucleotide binding]; other site 326425003791 salt bridge; other site 326425003792 sequence-specific DNA binding site [nucleotide binding]; other site 326425003793 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 326425003794 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 326425003795 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 326425003796 NAD(P) binding site [chemical binding]; other site 326425003797 LDH/MDH dimer interface [polypeptide binding]; other site 326425003798 substrate binding site [chemical binding]; other site 326425003799 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 326425003800 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 326425003801 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 326425003802 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 326425003803 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 326425003804 putative tRNA-binding site [nucleotide binding]; other site 326425003805 B3/4 domain; Region: B3_4; pfam03483 326425003806 tRNA synthetase B5 domain; Region: B5; smart00874 326425003807 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 326425003808 dimer interface [polypeptide binding]; other site 326425003809 motif 1; other site 326425003810 motif 3; other site 326425003811 motif 2; other site 326425003812 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 326425003813 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 326425003814 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 326425003815 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 326425003816 dimer interface [polypeptide binding]; other site 326425003817 motif 1; other site 326425003818 active site 326425003819 motif 2; other site 326425003820 motif 3; other site 326425003821 Predicted transcriptional regulators [Transcription]; Region: COG1733 326425003822 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 326425003823 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 326425003824 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 326425003825 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 326425003826 Acylphosphatase; Region: Acylphosphatase; pfam00708 326425003827 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 326425003828 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 326425003829 putative deacylase active site [active] 326425003830 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326425003831 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326425003832 dimerization interface [polypeptide binding]; other site 326425003833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326425003834 dimer interface [polypeptide binding]; other site 326425003835 phosphorylation site [posttranslational modification] 326425003836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326425003837 ATP binding site [chemical binding]; other site 326425003838 Mg2+ binding site [ion binding]; other site 326425003839 G-X-G motif; other site 326425003840 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326425003841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326425003842 active site 326425003843 phosphorylation site [posttranslational modification] 326425003844 intermolecular recognition site; other site 326425003845 dimerization interface [polypeptide binding]; other site 326425003846 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326425003847 DNA binding site [nucleotide binding] 326425003848 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 326425003849 hypothetical protein; Provisional; Region: PRK13670 326425003850 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 326425003851 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 326425003852 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326425003853 Zn2+ binding site [ion binding]; other site 326425003854 Mg2+ binding site [ion binding]; other site 326425003855 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 326425003856 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 326425003857 active site 326425003858 (T/H)XGH motif; other site 326425003859 GTPase YqeH; Provisional; Region: PRK13796 326425003860 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 326425003861 GTP/Mg2+ binding site [chemical binding]; other site 326425003862 G4 box; other site 326425003863 G5 box; other site 326425003864 G1 box; other site 326425003865 Switch I region; other site 326425003866 G2 box; other site 326425003867 G3 box; other site 326425003868 Switch II region; other site 326425003869 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 326425003870 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326425003871 active site 326425003872 motif I; other site 326425003873 motif II; other site 326425003874 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 326425003875 23S rRNA binding site [nucleotide binding]; other site 326425003876 L21 binding site [polypeptide binding]; other site 326425003877 L13 binding site [polypeptide binding]; other site 326425003878 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 326425003879 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 326425003880 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 326425003881 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 326425003882 Domain of unknown function (DUF389); Region: DUF389; pfam04087 326425003883 Family description; Region: ACT_7; pfam13840 326425003884 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 326425003885 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 326425003886 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 326425003887 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 326425003888 active site 326425003889 dimer interface [polypeptide binding]; other site 326425003890 motif 1; other site 326425003891 motif 2; other site 326425003892 motif 3; other site 326425003893 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 326425003894 anticodon binding site; other site 326425003895 primosomal protein DnaI; Reviewed; Region: PRK08939 326425003896 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 326425003897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326425003898 Walker A motif; other site 326425003899 ATP binding site [chemical binding]; other site 326425003900 Walker B motif; other site 326425003901 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 326425003902 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 326425003903 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 326425003904 ATP cone domain; Region: ATP-cone; pfam03477 326425003905 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 326425003906 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 326425003907 CoA-binding site [chemical binding]; other site 326425003908 ATP-binding [chemical binding]; other site 326425003909 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 326425003910 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 326425003911 DNA binding site [nucleotide binding] 326425003912 catalytic residue [active] 326425003913 H2TH interface [polypeptide binding]; other site 326425003914 putative catalytic residues [active] 326425003915 turnover-facilitating residue; other site 326425003916 intercalation triad [nucleotide binding]; other site 326425003917 8OG recognition residue [nucleotide binding]; other site 326425003918 putative reading head residues; other site 326425003919 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 326425003920 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 326425003921 DNA polymerase I; Provisional; Region: PRK05755 326425003922 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 326425003923 active site 326425003924 metal binding site 1 [ion binding]; metal-binding site 326425003925 putative 5' ssDNA interaction site; other site 326425003926 metal binding site 3; metal-binding site 326425003927 metal binding site 2 [ion binding]; metal-binding site 326425003928 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 326425003929 putative DNA binding site [nucleotide binding]; other site 326425003930 putative metal binding site [ion binding]; other site 326425003931 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 326425003932 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 326425003933 active site 326425003934 DNA binding site [nucleotide binding] 326425003935 catalytic site [active] 326425003936 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 326425003937 Predicted oxidoreductase [General function prediction only]; Region: COG3573 326425003938 FMN-binding domain; Region: FMN_bind; cl01081 326425003939 hypothetical protein; Validated; Region: PRK07121 326425003940 FMN-binding domain; Region: FMN_bind; cl01081 326425003941 L-aspartate oxidase; Provisional; Region: PRK06175 326425003942 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 326425003943 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326425003944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326425003945 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 326425003946 PLD-like domain; Region: PLDc_2; pfam13091 326425003947 putative homodimer interface [polypeptide binding]; other site 326425003948 putative active site [active] 326425003949 catalytic site [active] 326425003950 DEAD-like helicases superfamily; Region: DEXDc; smart00487 326425003951 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326425003952 ATP binding site [chemical binding]; other site 326425003953 putative Mg++ binding site [ion binding]; other site 326425003954 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326425003955 nucleotide binding region [chemical binding]; other site 326425003956 ATP-binding site [chemical binding]; other site 326425003957 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 326425003958 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 326425003959 HflC protein; Region: hflC; TIGR01932 326425003960 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 326425003961 RelB antitoxin; Region: RelB; cl01171 326425003962 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 326425003963 Zn binding site [ion binding]; other site 326425003964 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 326425003965 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 326425003966 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326425003967 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 326425003968 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 326425003969 catalytic triad [active] 326425003970 putative active site [active] 326425003971 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 326425003972 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 326425003973 Bacterial surface layer protein; Region: SLAP; pfam03217 326425003974 FtsX-like permease family; Region: FtsX; pfam02687 326425003975 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 326425003976 putative tRNA-binding site [nucleotide binding]; other site 326425003977 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 326425003978 catalytic residues [active] 326425003979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326425003980 S-adenosylmethionine binding site [chemical binding]; other site 326425003981 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 326425003982 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326425003983 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 326425003984 Walker A/P-loop; other site 326425003985 ATP binding site [chemical binding]; other site 326425003986 Q-loop/lid; other site 326425003987 ABC transporter signature motif; other site 326425003988 Walker B; other site 326425003989 D-loop; other site 326425003990 H-loop/switch region; other site 326425003991 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326425003992 non-specific DNA binding site [nucleotide binding]; other site 326425003993 salt bridge; other site 326425003994 sequence-specific DNA binding site [nucleotide binding]; other site 326425003995 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 326425003996 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 326425003997 HIT family signature motif; other site 326425003998 catalytic residue [active] 326425003999 YtxH-like protein; Region: YtxH; cl02079 326425004000 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 326425004001 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 326425004002 PAS domain; Region: PAS_10; pfam13596 326425004003 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 326425004004 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 326425004005 generic binding surface I; other site 326425004006 generic binding surface II; other site 326425004007 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326425004008 Zn2+ binding site [ion binding]; other site 326425004009 Mg2+ binding site [ion binding]; other site 326425004010 P-loop containing region of AAA domain; Region: AAA_29; cl17516 326425004011 AAA domain; Region: AAA_23; pfam13476 326425004012 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 326425004013 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 326425004014 active site 326425004015 metal binding site [ion binding]; metal-binding site 326425004016 DNA binding site [nucleotide binding] 326425004017 hypothetical protein; Provisional; Region: PRK13676 326425004018 Transglycosylase; Region: Transgly; pfam00912 326425004019 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 326425004020 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 326425004021 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 326425004022 MgtC family; Region: MgtC; pfam02308 326425004023 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 326425004024 amphipathic channel; other site 326425004025 Asn-Pro-Ala signature motifs; other site 326425004026 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 326425004027 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326425004028 EDD domain protein, DegV family; Region: DegV; TIGR00762 326425004029 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 326425004030 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 326425004031 PemK-like protein; Region: PemK; pfam02452 326425004032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326425004033 salt bridge; other site 326425004034 non-specific DNA binding site [nucleotide binding]; other site 326425004035 sequence-specific DNA binding site [nucleotide binding]; other site 326425004036 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326425004037 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326425004038 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 326425004039 Walker A/P-loop; other site 326425004040 ATP binding site [chemical binding]; other site 326425004041 Q-loop/lid; other site 326425004042 ABC transporter signature motif; other site 326425004043 Walker B; other site 326425004044 D-loop; other site 326425004045 H-loop/switch region; other site 326425004046 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326425004047 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326425004048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326425004049 Walker A/P-loop; other site 326425004050 ATP binding site [chemical binding]; other site 326425004051 Q-loop/lid; other site 326425004052 ABC transporter signature motif; other site 326425004053 Walker B; other site 326425004054 D-loop; other site 326425004055 H-loop/switch region; other site 326425004056 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 326425004057 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 326425004058 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 326425004059 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326425004060 Walker A/P-loop; other site 326425004061 ATP binding site [chemical binding]; other site 326425004062 Q-loop/lid; other site 326425004063 ABC transporter signature motif; other site 326425004064 Walker B; other site 326425004065 D-loop; other site 326425004066 H-loop/switch region; other site 326425004067 WbqC-like protein family; Region: WbqC; pfam08889 326425004068 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 326425004069 nudix motif; other site 326425004070 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 326425004071 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 326425004072 intersubunit interface [polypeptide binding]; other site 326425004073 active site 326425004074 zinc binding site [ion binding]; other site 326425004075 Na+ binding site [ion binding]; other site 326425004076 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 326425004077 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 326425004078 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 326425004079 active site 326425004080 HIGH motif; other site 326425004081 KMSK motif region; other site 326425004082 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 326425004083 tRNA binding surface [nucleotide binding]; other site 326425004084 anticodon binding site; other site 326425004085 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 326425004086 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 326425004087 Predicted transcriptional regulators [Transcription]; Region: COG1695 326425004088 Transcriptional regulator PadR-like family; Region: PadR; cl17335 326425004089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 326425004090 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 326425004091 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 326425004092 putative substrate binding site [chemical binding]; other site 326425004093 putative ATP binding site [chemical binding]; other site 326425004094 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 326425004095 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 326425004096 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 326425004097 PspC domain; Region: PspC; pfam04024 326425004098 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 326425004099 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 326425004100 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326425004101 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326425004102 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326425004103 dimerization interface [polypeptide binding]; other site 326425004104 putative DNA binding site [nucleotide binding]; other site 326425004105 putative Zn2+ binding site [ion binding]; other site 326425004106 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 326425004107 active site residue [active] 326425004108 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 326425004109 catalytic residues [active] 326425004110 Bacterial surface layer protein; Region: SLAP; pfam03217 326425004111 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 326425004112 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 326425004113 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 326425004114 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 326425004115 HIGH motif; other site 326425004116 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 326425004117 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 326425004118 active site 326425004119 KMSKS motif; other site 326425004120 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 326425004121 tRNA binding surface [nucleotide binding]; other site 326425004122 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 326425004123 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 326425004124 active site 326425004125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326425004126 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326425004127 putative substrate translocation pore; other site 326425004128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326425004129 S-adenosylmethionine synthetase; Validated; Region: PRK05250 326425004130 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 326425004131 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 326425004132 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 326425004133 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 326425004134 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 326425004135 intersubunit interface [polypeptide binding]; other site 326425004136 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 326425004137 SmpB-tmRNA interface; other site 326425004138 ribonuclease R; Region: RNase_R; TIGR02063 326425004139 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 326425004140 RNB domain; Region: RNB; pfam00773 326425004141 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 326425004142 RNA binding site [nucleotide binding]; other site 326425004143 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 326425004144 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 326425004145 Sulfatase; Region: Sulfatase; pfam00884 326425004146 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 326425004147 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326425004148 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326425004149 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326425004150 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 326425004151 putative ADP-binding pocket [chemical binding]; other site 326425004152 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 326425004153 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326425004154 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326425004155 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 326425004156 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 326425004157 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 326425004158 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 326425004159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326425004160 active site 326425004161 motif I; other site 326425004162 motif II; other site 326425004163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326425004164 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 326425004165 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 326425004166 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 326425004167 active site 326425004168 metal binding site [ion binding]; metal-binding site 326425004169 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 326425004170 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 326425004171 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 326425004172 active site 326425004173 catalytic site [active] 326425004174 metal binding site [ion binding]; metal-binding site 326425004175 catabolite control protein A; Region: ccpA; TIGR01481 326425004176 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326425004177 DNA binding site [nucleotide binding] 326425004178 domain linker motif; other site 326425004179 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 326425004180 dimerization interface [polypeptide binding]; other site 326425004181 effector binding site; other site 326425004182 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 326425004183 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 326425004184 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 326425004185 active site 326425004186 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 326425004187 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 326425004188 Mechanosensitive ion channel; Region: MS_channel; pfam00924 326425004189 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 326425004190 active site 326425004191 dimerization interface [polypeptide binding]; other site 326425004192 glutamate racemase; Provisional; Region: PRK00865 326425004193 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 326425004194 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 326425004195 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 326425004196 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 326425004197 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 326425004198 catalytic residues [active] 326425004199 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 326425004200 MutS domain III; Region: MutS_III; pfam05192 326425004201 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 326425004202 Walker A/P-loop; other site 326425004203 ATP binding site [chemical binding]; other site 326425004204 Q-loop/lid; other site 326425004205 ABC transporter signature motif; other site 326425004206 Walker B; other site 326425004207 D-loop; other site 326425004208 H-loop/switch region; other site 326425004209 Smr domain; Region: Smr; pfam01713 326425004210 hypothetical protein; Provisional; Region: PRK13678 326425004211 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 326425004212 hypothetical protein; Provisional; Region: PRK05473 326425004213 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 326425004214 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 326425004215 motif 1; other site 326425004216 active site 326425004217 motif 2; other site 326425004218 motif 3; other site 326425004219 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 326425004220 DHHA1 domain; Region: DHHA1; pfam02272 326425004221 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 326425004222 DEAD-like helicases superfamily; Region: DEXDc; smart00487 326425004223 ATP binding site [chemical binding]; other site 326425004224 putative Mg++ binding site [ion binding]; other site 326425004225 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326425004226 nucleotide binding region [chemical binding]; other site 326425004227 ATP-binding site [chemical binding]; other site 326425004228 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 326425004229 DHH family; Region: DHH; pfam01368 326425004230 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 326425004231 active site 326425004232 DNA polymerase IV; Validated; Region: PRK02406 326425004233 DNA binding site [nucleotide binding] 326425004234 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 326425004235 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 326425004236 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 326425004237 Preprotein translocase subunit; Region: YajC; cl00806 326425004238 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 326425004239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326425004240 Walker A motif; other site 326425004241 ATP binding site [chemical binding]; other site 326425004242 Walker B motif; other site 326425004243 arginine finger; other site 326425004244 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 326425004245 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 326425004246 RuvA N terminal domain; Region: RuvA_N; pfam01330 326425004247 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 326425004248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326425004249 ATP binding site [chemical binding]; other site 326425004250 Mg2+ binding site [ion binding]; other site 326425004251 G-X-G motif; other site 326425004252 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 326425004253 ATP binding site [chemical binding]; other site 326425004254 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 326425004255 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 326425004256 MutS domain I; Region: MutS_I; pfam01624 326425004257 MutS domain II; Region: MutS_II; pfam05188 326425004258 MutS domain III; Region: MutS_III; pfam05192 326425004259 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 326425004260 Walker A/P-loop; other site 326425004261 ATP binding site [chemical binding]; other site 326425004262 Q-loop/lid; other site 326425004263 ABC transporter signature motif; other site 326425004264 Walker B; other site 326425004265 D-loop; other site 326425004266 H-loop/switch region; other site 326425004267 chaperonin GroL; Region: GroEL; TIGR02348 326425004268 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 326425004269 ring oligomerisation interface [polypeptide binding]; other site 326425004270 ATP/Mg binding site [chemical binding]; other site 326425004271 stacking interactions; other site 326425004272 hinge regions; other site 326425004273 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 326425004274 oligomerisation interface [polypeptide binding]; other site 326425004275 mobile loop; other site 326425004276 roof hairpin; other site 326425004277 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 326425004278 Int/Topo IB signature motif; other site 326425004279 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 326425004280 catalytic triad [active] 326425004281 putative active site [active] 326425004282 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 326425004283 Bacterial surface layer protein; Region: SLAP; pfam03217 326425004284 Bacterial surface layer protein; Region: SLAP; pfam03217 326425004285 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 326425004286 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 326425004287 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 326425004288 HPr interaction site; other site 326425004289 glycerol kinase (GK) interaction site [polypeptide binding]; other site 326425004290 active site 326425004291 phosphorylation site [posttranslational modification] 326425004292 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 326425004293 LytTr DNA-binding domain; Region: LytTR; smart00850 326425004294 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 326425004295 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 326425004296 CoA binding domain; Region: CoA_binding; pfam02629 326425004297 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 326425004298 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326425004299 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326425004300 ABC transporter; Region: ABC_tran_2; pfam12848 326425004301 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326425004302 ABC transporter; Region: ABC_tran_2; pfam12848 326425004303 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 326425004304 CoA-transferase family III; Region: CoA_transf_3; pfam02515 326425004305 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 326425004306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326425004307 DNA-binding site [nucleotide binding]; DNA binding site 326425004308 UTRA domain; Region: UTRA; pfam07702 326425004309 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 326425004310 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 326425004311 UGMP family protein; Validated; Region: PRK09604 326425004312 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 326425004313 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 326425004314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326425004315 Coenzyme A binding pocket [chemical binding]; other site 326425004316 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 326425004317 Glycoprotease family; Region: Peptidase_M22; pfam00814 326425004318 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 326425004319 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 326425004320 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 326425004321 active site 326425004322 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 326425004323 active site 2 [active] 326425004324 active site 1 [active] 326425004325 Predicted methyltransferases [General function prediction only]; Region: COG0313 326425004326 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 326425004327 putative SAM binding site [chemical binding]; other site 326425004328 putative homodimer interface [polypeptide binding]; other site 326425004329 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 326425004330 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 326425004331 DNA polymerase III subunit delta'; Validated; Region: PRK08485 326425004332 Protein of unknown function (DUF970); Region: DUF970; cl17525 326425004333 thymidylate kinase; Validated; Region: tmk; PRK00698 326425004334 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 326425004335 TMP-binding site; other site 326425004336 ATP-binding site [chemical binding]; other site 326425004337 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 326425004338 recombination protein RecR; Reviewed; Region: recR; PRK00076 326425004339 RecR protein; Region: RecR; pfam02132 326425004340 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 326425004341 putative active site [active] 326425004342 putative metal-binding site [ion binding]; other site 326425004343 tetramer interface [polypeptide binding]; other site 326425004344 hypothetical protein; Validated; Region: PRK00153 326425004345 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 326425004346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326425004347 Walker A motif; other site 326425004348 ATP binding site [chemical binding]; other site 326425004349 Walker B motif; other site 326425004350 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 326425004351 nucleoside/Zn binding site; other site 326425004352 dimer interface [polypeptide binding]; other site 326425004353 catalytic motif [active] 326425004354 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 326425004355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326425004356 S-adenosylmethionine binding site [chemical binding]; other site 326425004357 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 326425004358 core dimer interface [polypeptide binding]; other site 326425004359 peripheral dimer interface [polypeptide binding]; other site 326425004360 L10 interface [polypeptide binding]; other site 326425004361 L11 interface [polypeptide binding]; other site 326425004362 putative EF-Tu interaction site [polypeptide binding]; other site 326425004363 putative EF-G interaction site [polypeptide binding]; other site 326425004364 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 326425004365 23S rRNA interface [nucleotide binding]; other site 326425004366 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 326425004367 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 326425004368 PhoU domain; Region: PhoU; pfam01895 326425004369 PhoU domain; Region: PhoU; pfam01895 326425004370 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14251 326425004371 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 326425004372 Walker A/P-loop; other site 326425004373 ATP binding site [chemical binding]; other site 326425004374 Q-loop/lid; other site 326425004375 ABC transporter signature motif; other site 326425004376 Walker B; other site 326425004377 D-loop; other site 326425004378 H-loop/switch region; other site 326425004379 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 326425004380 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 326425004381 Walker A/P-loop; other site 326425004382 ATP binding site [chemical binding]; other site 326425004383 Q-loop/lid; other site 326425004384 ABC transporter signature motif; other site 326425004385 Walker B; other site 326425004386 D-loop; other site 326425004387 H-loop/switch region; other site 326425004388 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 326425004389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425004390 dimer interface [polypeptide binding]; other site 326425004391 conserved gate region; other site 326425004392 putative PBP binding loops; other site 326425004393 ABC-ATPase subunit interface; other site 326425004394 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 326425004395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425004396 dimer interface [polypeptide binding]; other site 326425004397 conserved gate region; other site 326425004398 putative PBP binding loops; other site 326425004399 ABC-ATPase subunit interface; other site 326425004400 PBP superfamily domain; Region: PBP_like_2; cl17296 326425004401 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 326425004402 mRNA/rRNA interface [nucleotide binding]; other site 326425004403 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 326425004404 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 326425004405 23S rRNA interface [nucleotide binding]; other site 326425004406 L7/L12 interface [polypeptide binding]; other site 326425004407 putative thiostrepton binding site; other site 326425004408 L25 interface [polypeptide binding]; other site 326425004409 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 326425004410 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 326425004411 putative homodimer interface [polypeptide binding]; other site 326425004412 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 326425004413 heterodimer interface [polypeptide binding]; other site 326425004414 homodimer interface [polypeptide binding]; other site 326425004415 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 326425004416 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 326425004417 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 326425004418 N- and C-terminal domain interface [polypeptide binding]; other site 326425004419 active site 326425004420 catalytic site [active] 326425004421 metal binding site [ion binding]; metal-binding site 326425004422 carbohydrate binding site [chemical binding]; other site 326425004423 ATP binding site [chemical binding]; other site 326425004424 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 326425004425 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 326425004426 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 326425004427 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 326425004428 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 326425004429 active site 326425004430 metal binding site [ion binding]; metal-binding site 326425004431 dimerization interface [polypeptide binding]; other site 326425004432 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 326425004433 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 326425004434 active site 326425004435 HIGH motif; other site 326425004436 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 326425004437 KMSKS motif; other site 326425004438 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 326425004439 tRNA binding surface [nucleotide binding]; other site 326425004440 anticodon binding site; other site 326425004441 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 326425004442 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 326425004443 active site 326425004444 HIGH motif; other site 326425004445 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 326425004446 active site 326425004447 KMSKS motif; other site 326425004448 DNA repair protein RadA; Provisional; Region: PRK11823 326425004449 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 326425004450 Walker A motif/ATP binding site; other site 326425004451 ATP binding site [chemical binding]; other site 326425004452 Walker B motif; other site 326425004453 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 326425004454 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 326425004455 trimer interface [polypeptide binding]; other site 326425004456 active site 326425004457 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 326425004458 magnesium-transporting ATPase; Provisional; Region: PRK15122 326425004459 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 326425004460 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326425004461 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 326425004462 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326425004463 motif II; other site 326425004464 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 326425004465 AAA domain; Region: AAA_33; pfam13671 326425004466 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326425004467 catalytic core [active] 326425004468 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326425004469 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 326425004470 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 326425004471 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326425004472 catalytic core [active] 326425004473 DJ-1 family protein; Region: not_thiJ; TIGR01383 326425004474 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 326425004475 conserved cys residue [active] 326425004476 Protein of unknown function (DUF805); Region: DUF805; pfam05656 326425004477 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 326425004478 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 326425004479 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326425004480 Plasmid replication protein; Region: Rep_2; pfam01719 326425004481 RNA helicase; Region: RNA_helicase; pfam00910 326425004482 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 326425004483 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326425004484 active site 326425004485 DNA binding site [nucleotide binding] 326425004486 Int/Topo IB signature motif; other site 326425004487 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 326425004488 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 326425004489 23S rRNA interface [nucleotide binding]; other site 326425004490 L3 interface [polypeptide binding]; other site 326425004491 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 326425004492 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 326425004493 dimerization interface 3.5A [polypeptide binding]; other site 326425004494 active site 326425004495 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 326425004496 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13641 326425004497 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326425004498 Walker A/P-loop; other site 326425004499 ATP binding site [chemical binding]; other site 326425004500 Q-loop/lid; other site 326425004501 ABC transporter signature motif; other site 326425004502 Walker B; other site 326425004503 D-loop; other site 326425004504 H-loop/switch region; other site 326425004505 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13640 326425004506 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326425004507 Walker A/P-loop; other site 326425004508 ATP binding site [chemical binding]; other site 326425004509 Q-loop/lid; other site 326425004510 ABC transporter signature motif; other site 326425004511 Walker B; other site 326425004512 D-loop; other site 326425004513 H-loop/switch region; other site 326425004514 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 326425004515 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 326425004516 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 326425004517 alphaNTD homodimer interface [polypeptide binding]; other site 326425004518 alphaNTD - beta interaction site [polypeptide binding]; other site 326425004519 alphaNTD - beta' interaction site [polypeptide binding]; other site 326425004520 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 326425004521 30S ribosomal protein S11; Validated; Region: PRK05309 326425004522 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 326425004523 30S ribosomal protein S13; Region: bact_S13; TIGR03631 326425004524 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 326425004525 rRNA binding site [nucleotide binding]; other site 326425004526 predicted 30S ribosome binding site; other site 326425004527 adenylate kinase; Reviewed; Region: adk; PRK00279 326425004528 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 326425004529 AMP-binding site [chemical binding]; other site 326425004530 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 326425004531 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 326425004532 SecY translocase; Region: SecY; pfam00344 326425004533 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 326425004534 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 326425004535 23S rRNA binding site [nucleotide binding]; other site 326425004536 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 326425004537 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 326425004538 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 326425004539 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 326425004540 23S rRNA interface [nucleotide binding]; other site 326425004541 L21e interface [polypeptide binding]; other site 326425004542 5S rRNA interface [nucleotide binding]; other site 326425004543 L27 interface [polypeptide binding]; other site 326425004544 L5 interface [polypeptide binding]; other site 326425004545 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 326425004546 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 326425004547 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 326425004548 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 326425004549 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 326425004550 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 326425004551 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 326425004552 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 326425004553 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 326425004554 RNA binding site [nucleotide binding]; other site 326425004555 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 326425004556 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 326425004557 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 326425004558 23S rRNA interface [nucleotide binding]; other site 326425004559 putative translocon interaction site; other site 326425004560 signal recognition particle (SRP54) interaction site; other site 326425004561 L23 interface [polypeptide binding]; other site 326425004562 trigger factor interaction site; other site 326425004563 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 326425004564 23S rRNA interface [nucleotide binding]; other site 326425004565 5S rRNA interface [nucleotide binding]; other site 326425004566 putative antibiotic binding site [chemical binding]; other site 326425004567 L25 interface [polypeptide binding]; other site 326425004568 L27 interface [polypeptide binding]; other site 326425004569 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 326425004570 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 326425004571 G-X-X-G motif; other site 326425004572 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 326425004573 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 326425004574 putative translocon binding site; other site 326425004575 protein-rRNA interface [nucleotide binding]; other site 326425004576 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 326425004577 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 326425004578 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 326425004579 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 326425004580 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 326425004581 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 326425004582 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 326425004583 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 326425004584 elongation factor G; Reviewed; Region: PRK12739 326425004585 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 326425004586 G1 box; other site 326425004587 putative GEF interaction site [polypeptide binding]; other site 326425004588 GTP/Mg2+ binding site [chemical binding]; other site 326425004589 Switch I region; other site 326425004590 G2 box; other site 326425004591 G3 box; other site 326425004592 Switch II region; other site 326425004593 G4 box; other site 326425004594 G5 box; other site 326425004595 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 326425004596 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 326425004597 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 326425004598 30S ribosomal protein S7; Validated; Region: PRK05302 326425004599 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 326425004600 S17 interaction site [polypeptide binding]; other site 326425004601 S8 interaction site; other site 326425004602 16S rRNA interaction site [nucleotide binding]; other site 326425004603 streptomycin interaction site [chemical binding]; other site 326425004604 23S rRNA interaction site [nucleotide binding]; other site 326425004605 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 326425004606 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 326425004607 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 326425004608 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 326425004609 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 326425004610 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 326425004611 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 326425004612 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 326425004613 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 326425004614 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 326425004615 G-loop; other site 326425004616 DNA binding site [nucleotide binding] 326425004617 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 326425004618 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 326425004619 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 326425004620 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 326425004621 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 326425004622 RPB1 interaction site [polypeptide binding]; other site 326425004623 RPB10 interaction site [polypeptide binding]; other site 326425004624 RPB11 interaction site [polypeptide binding]; other site 326425004625 RPB3 interaction site [polypeptide binding]; other site 326425004626 RPB12 interaction site [polypeptide binding]; other site 326425004627 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 326425004628 Clp amino terminal domain; Region: Clp_N; pfam02861 326425004629 Clp amino terminal domain; Region: Clp_N; pfam02861 326425004630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326425004631 Walker A motif; other site 326425004632 ATP binding site [chemical binding]; other site 326425004633 Walker B motif; other site 326425004634 arginine finger; other site 326425004635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326425004636 Walker A motif; other site 326425004637 ATP binding site [chemical binding]; other site 326425004638 Walker B motif; other site 326425004639 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 326425004640 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 326425004641 GAF domain; Region: GAF_2; pfam13185 326425004642 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 326425004643 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 326425004644 dimer interface [polypeptide binding]; other site 326425004645 putative anticodon binding site; other site 326425004646 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 326425004647 motif 1; other site 326425004648 active site 326425004649 motif 2; other site 326425004650 motif 3; other site 326425004651 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 326425004652 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 326425004653 FMN binding site [chemical binding]; other site 326425004654 active site 326425004655 catalytic residues [active] 326425004656 substrate binding site [chemical binding]; other site 326425004657 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 326425004658 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 326425004659 dimerization interface [polypeptide binding]; other site 326425004660 domain crossover interface; other site 326425004661 redox-dependent activation switch; other site 326425004662 FtsH Extracellular; Region: FtsH_ext; pfam06480 326425004663 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 326425004664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326425004665 Walker A motif; other site 326425004666 ATP binding site [chemical binding]; other site 326425004667 Walker B motif; other site 326425004668 arginine finger; other site 326425004669 Peptidase family M41; Region: Peptidase_M41; pfam01434 326425004670 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 326425004671 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 326425004672 Ligand Binding Site [chemical binding]; other site 326425004673 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 326425004674 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 326425004675 RNA binding site [nucleotide binding]; other site 326425004676 Septum formation initiator; Region: DivIC; cl17659 326425004677 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326425004678 RNA binding surface [nucleotide binding]; other site 326425004679 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 326425004680 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 326425004681 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326425004682 ATP binding site [chemical binding]; other site 326425004683 putative Mg++ binding site [ion binding]; other site 326425004684 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326425004685 nucleotide binding region [chemical binding]; other site 326425004686 ATP-binding site [chemical binding]; other site 326425004687 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 326425004688 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 326425004689 putative active site [active] 326425004690 catalytic residue [active] 326425004691 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 326425004692 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 326425004693 tetramer (dimer of dimers) interface [polypeptide binding]; other site 326425004694 NAD binding site [chemical binding]; other site 326425004695 dimer interface [polypeptide binding]; other site 326425004696 substrate binding site [chemical binding]; other site 326425004697 FOG: CBS domain [General function prediction only]; Region: COG0517 326425004698 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 326425004699 alanine racemase; Reviewed; Region: alr; PRK00053 326425004700 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 326425004701 active site 326425004702 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 326425004703 dimer interface [polypeptide binding]; other site 326425004704 substrate binding site [chemical binding]; other site 326425004705 catalytic residues [active] 326425004706 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 326425004707 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 326425004708 DEAD-like helicases superfamily; Region: DEXDc; smart00487 326425004709 ATP binding site [chemical binding]; other site 326425004710 Mg++ binding site [ion binding]; other site 326425004711 motif III; other site 326425004712 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326425004713 nucleotide binding region [chemical binding]; other site 326425004714 ATP-binding site [chemical binding]; other site 326425004715 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 326425004716 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 326425004717 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326425004718 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 326425004719 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 326425004720 Eukaryotic phosphomannomutase; Region: PMM; cl17107 326425004721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 326425004722 Bacterial surface layer protein; Region: SLAP; pfam03217 326425004723 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326425004724 non-specific DNA binding site [nucleotide binding]; other site 326425004725 salt bridge; other site 326425004726 sequence-specific DNA binding site [nucleotide binding]; other site 326425004727 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 326425004728 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 326425004729 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 326425004730 dimer interface [polypeptide binding]; other site 326425004731 active site 326425004732 glycine-pyridoxal phosphate binding site [chemical binding]; other site 326425004733 folate binding site [chemical binding]; other site 326425004734 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 326425004735 putative active site [active] 326425004736 catalytic triad [active] 326425004737 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 326425004738 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 326425004739 PA/protease or protease-like domain interface [polypeptide binding]; other site 326425004740 catalytic residues [active] 326425004741 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 326425004742 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 326425004743 Bacterial surface layer protein; Region: SLAP; pfam03217 326425004744 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 326425004745 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 326425004746 GMP synthase; Reviewed; Region: guaA; PRK00074 326425004747 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 326425004748 AMP/PPi binding site [chemical binding]; other site 326425004749 candidate oxyanion hole; other site 326425004750 catalytic triad [active] 326425004751 potential glutamine specificity residues [chemical binding]; other site 326425004752 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 326425004753 ATP Binding subdomain [chemical binding]; other site 326425004754 Ligand Binding sites [chemical binding]; other site 326425004755 Dimerization subdomain; other site 326425004756 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326425004757 non-specific DNA binding site [nucleotide binding]; other site 326425004758 salt bridge; other site 326425004759 sequence-specific DNA binding site [nucleotide binding]; other site 326425004760 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326425004761 active site 326425004762 xanthine permease; Region: pbuX; TIGR03173 326425004763 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 326425004764 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 326425004765 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326425004766 Peptidase family C69; Region: Peptidase_C69; pfam03577 326425004767 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 326425004768 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 326425004769 hinge; other site 326425004770 active site 326425004771 CTP synthetase; Validated; Region: pyrG; PRK05380 326425004772 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 326425004773 Catalytic site [active] 326425004774 active site 326425004775 UTP binding site [chemical binding]; other site 326425004776 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 326425004777 active site 326425004778 putative oxyanion hole; other site 326425004779 catalytic triad [active] 326425004780 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 326425004781 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 326425004782 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 326425004783 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326425004784 Zn2+ binding site [ion binding]; other site 326425004785 Mg2+ binding site [ion binding]; other site 326425004786 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 326425004787 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 326425004788 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326425004789 active site 326425004790 Bacterial surface layer protein; Region: SLAP; pfam03217 326425004791 Bacterial surface layer protein; Region: SLAP; pfam03217 326425004792 Bacterial surface layer protein; Region: SLAP; pfam03217 326425004793 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 326425004794 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 326425004795 Substrate binding site; other site 326425004796 Mg++ binding site; other site 326425004797 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 326425004798 active site 326425004799 substrate binding site [chemical binding]; other site 326425004800 CoA binding site [chemical binding]; other site 326425004801 pur operon repressor; Provisional; Region: PRK09213 326425004802 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 326425004803 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326425004804 active site 326425004805 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 326425004806 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 326425004807 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 326425004808 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 326425004809 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 326425004810 putative active site [active] 326425004811 putative metal binding site [ion binding]; other site 326425004812 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 326425004813 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 326425004814 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 326425004815 active site 326425004816 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 326425004817 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 326425004818 active site 326425004819 HIGH motif; other site 326425004820 KMSKS motif; other site 326425004821 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 326425004822 tRNA binding surface [nucleotide binding]; other site 326425004823 anticodon binding site; other site 326425004824 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 326425004825 dimer interface [polypeptide binding]; other site 326425004826 putative tRNA-binding site [nucleotide binding]; other site 326425004827 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 326425004828 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 326425004829 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326425004830 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 326425004831 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 326425004832 catalytic motif [active] 326425004833 Zn binding site [ion binding]; other site 326425004834 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 326425004835 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 326425004836 active site 326425004837 HIGH motif; other site 326425004838 dimer interface [polypeptide binding]; other site 326425004839 KMSKS motif; other site 326425004840 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 326425004841 CAAX protease self-immunity; Region: Abi; pfam02517 326425004842 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 326425004843 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 326425004844 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 326425004845 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 326425004846 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 326425004847 putative dimer interface [polypeptide binding]; other site 326425004848 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 326425004849 trimer interface [polypeptide binding]; other site 326425004850 active site 326425004851 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 326425004852 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326425004853 Walker A/P-loop; other site 326425004854 ATP binding site [chemical binding]; other site 326425004855 Q-loop/lid; other site 326425004856 ABC transporter signature motif; other site 326425004857 Walker B; other site 326425004858 D-loop; other site 326425004859 H-loop/switch region; other site 326425004860 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 326425004861 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 326425004862 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326425004863 Walker A/P-loop; other site 326425004864 ATP binding site [chemical binding]; other site 326425004865 Q-loop/lid; other site 326425004866 ABC transporter signature motif; other site 326425004867 Walker B; other site 326425004868 D-loop; other site 326425004869 H-loop/switch region; other site 326425004870 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 326425004871 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 326425004872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425004873 dimer interface [polypeptide binding]; other site 326425004874 conserved gate region; other site 326425004875 putative PBP binding loops; other site 326425004876 ABC-ATPase subunit interface; other site 326425004877 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 326425004878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326425004879 dimer interface [polypeptide binding]; other site 326425004880 conserved gate region; other site 326425004881 putative PBP binding loops; other site 326425004882 ABC-ATPase subunit interface; other site 326425004883 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 326425004884 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 326425004885 active site 326425004886 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 326425004887 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 326425004888 peptide binding site [polypeptide binding]; other site 326425004889 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 326425004890 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 326425004891 peptide binding site [polypeptide binding]; other site 326425004892 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 326425004893 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 326425004894 Zn2+ binding site [ion binding]; other site 326425004895 Mg2+ binding site [ion binding]; other site 326425004896 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 326425004897 trimer interface [polypeptide binding]; other site 326425004898 active site 326425004899 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 326425004900 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 326425004901 active site 326425004902 HIGH motif; other site 326425004903 dimer interface [polypeptide binding]; other site 326425004904 KMSKS motif; other site 326425004905 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326425004906 RNA binding surface [nucleotide binding]; other site 326425004907 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 326425004908 Interdomain contacts; other site 326425004909 Cytokine receptor motif; other site 326425004910 Sulfatase; Region: Sulfatase; cl17466 326425004911 membrane protein; Provisional; Region: PRK14411 326425004912 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 326425004913 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 326425004914 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 326425004915 putative substrate binding pocket [chemical binding]; other site 326425004916 AC domain interface; other site 326425004917 catalytic triad [active] 326425004918 AB domain interface; other site 326425004919 interchain disulfide; other site 326425004920 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326425004921 catalytic core [active] 326425004922 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326425004923 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 326425004924 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326425004925 Soluble P-type ATPase [General function prediction only]; Region: COG4087 326425004926 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 326425004927 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 326425004928 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 326425004929 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326425004930 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326425004931 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 326425004932 Walker A/P-loop; other site 326425004933 ATP binding site [chemical binding]; other site 326425004934 Q-loop/lid; other site 326425004935 ABC transporter signature motif; other site 326425004936 Walker B; other site 326425004937 D-loop; other site 326425004938 H-loop/switch region; other site 326425004939 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 326425004940 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 326425004941 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326425004942 non-specific DNA binding site [nucleotide binding]; other site 326425004943 salt bridge; other site 326425004944 sequence-specific DNA binding site [nucleotide binding]; other site 326425004945 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 326425004946 CAAX protease self-immunity; Region: Abi; pfam02517 326425004947 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 326425004948 putative active site [active] 326425004949 Predicted membrane protein [Function unknown]; Region: COG4684 326425004950 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326425004951 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326425004952 active site 326425004953 catalytic tetrad [active] 326425004954 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 326425004955 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 326425004956 active site 326425004957 trimer interface [polypeptide binding]; other site 326425004958 allosteric site; other site 326425004959 active site lid [active] 326425004960 hexamer (dimer of trimers) interface [polypeptide binding]; other site 326425004961 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 326425004962 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 326425004963 Substrate-binding site [chemical binding]; other site 326425004964 Substrate specificity [chemical binding]; other site 326425004965 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 326425004966 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 326425004967 Substrate-binding site [chemical binding]; other site 326425004968 Substrate specificity [chemical binding]; other site 326425004969 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 326425004970 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 326425004971 active site 326425004972 motif I; other site 326425004973 motif II; other site 326425004974 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 326425004975 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 326425004976 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 326425004977 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 326425004978 DNA binding residues [nucleotide binding] 326425004979 dimer interface [polypeptide binding]; other site 326425004980 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 326425004981 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 326425004982 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 326425004983 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 326425004984 Penicillinase repressor; Region: Pencillinase_R; pfam03965 326425004985 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 326425004986 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 326425004987 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 326425004988 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326425004989 Soluble P-type ATPase [General function prediction only]; Region: COG4087 326425004990 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 326425004991 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 326425004992 Cl- selectivity filter; other site 326425004993 Cl- binding residues [ion binding]; other site 326425004994 pore gating glutamate residue; other site 326425004995 dimer interface [polypeptide binding]; other site 326425004996 H+/Cl- coupling transport residue; other site 326425004997 TrkA-C domain; Region: TrkA_C; pfam02080 326425004998 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 326425004999 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 326425005000 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 326425005001 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 326425005002 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 326425005003 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 326425005004 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 326425005005 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 326425005006 trmE is a tRNA modification GTPase; Region: trmE; cd04164 326425005007 G1 box; other site 326425005008 GTP/Mg2+ binding site [chemical binding]; other site 326425005009 Switch I region; other site 326425005010 G2 box; other site 326425005011 Switch II region; other site 326425005012 G3 box; other site 326425005013 G4 box; other site 326425005014 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 326425005015 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 326425005016 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 326425005017 ribonuclease P; Reviewed; Region: rnpA; PRK00499 326425005018 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399