-- dump date 20140619_123548 -- class Genbank::misc_feature -- table misc_feature_note -- id note 405566000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 405566000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 405566000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405566000004 Walker A motif; other site 405566000005 ATP binding site [chemical binding]; other site 405566000006 Walker B motif; other site 405566000007 arginine finger; other site 405566000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 405566000009 DnaA box-binding interface [nucleotide binding]; other site 405566000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 405566000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 405566000012 putative DNA binding surface [nucleotide binding]; other site 405566000013 dimer interface [polypeptide binding]; other site 405566000014 beta-clamp/clamp loader binding surface; other site 405566000015 beta-clamp/translesion DNA polymerase binding surface; other site 405566000016 S4 domain; Region: S4_2; pfam13275 405566000017 recombination protein F; Reviewed; Region: recF; PRK00064 405566000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 405566000019 Walker A/P-loop; other site 405566000020 ATP binding site [chemical binding]; other site 405566000021 Q-loop/lid; other site 405566000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405566000023 ABC transporter signature motif; other site 405566000024 Walker B; other site 405566000025 D-loop; other site 405566000026 H-loop/switch region; other site 405566000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 405566000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405566000029 Mg2+ binding site [ion binding]; other site 405566000030 G-X-G motif; other site 405566000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 405566000032 anchoring element; other site 405566000033 dimer interface [polypeptide binding]; other site 405566000034 ATP binding site [chemical binding]; other site 405566000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 405566000036 active site 405566000037 putative metal-binding site [ion binding]; other site 405566000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 405566000039 DNA gyrase subunit A; Validated; Region: PRK05560 405566000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 405566000041 CAP-like domain; other site 405566000042 active site 405566000043 primary dimer interface [polypeptide binding]; other site 405566000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405566000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405566000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405566000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405566000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405566000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405566000050 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 405566000051 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 405566000052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 405566000053 dimer interface [polypeptide binding]; other site 405566000054 ssDNA binding site [nucleotide binding]; other site 405566000055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405566000056 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 405566000057 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566000058 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566000059 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 405566000060 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 405566000061 DHH family; Region: DHH; pfam01368 405566000062 DHHA1 domain; Region: DHHA1; pfam02272 405566000063 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 405566000064 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 405566000065 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 405566000066 replicative DNA helicase; Region: DnaB; TIGR00665 405566000067 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 405566000068 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 405566000069 Walker A motif; other site 405566000070 ATP binding site [chemical binding]; other site 405566000071 Walker B motif; other site 405566000072 DNA binding loops [nucleotide binding] 405566000073 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 405566000074 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405566000075 substrate binding pocket [chemical binding]; other site 405566000076 membrane-bound complex binding site; other site 405566000077 hinge residues; other site 405566000078 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566000079 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566000080 EDD domain protein, DegV family; Region: DegV; TIGR00762 405566000081 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405566000082 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 405566000083 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 405566000084 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 405566000085 MgtC family; Region: MgtC; pfam02308 405566000086 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 405566000087 DNA methylase; Region: N6_N4_Mtase; pfam01555 405566000088 DNA methylase; Region: N6_N4_Mtase; pfam01555 405566000089 Restriction endonuclease [Defense mechanisms]; Region: COG3587 405566000090 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405566000091 ATP binding site [chemical binding]; other site 405566000092 putative Mg++ binding site [ion binding]; other site 405566000093 Transposase; Region: DEDD_Tnp_IS110; pfam01548 405566000094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 405566000095 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 405566000096 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566000097 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566000098 Restriction endonuclease; Region: Mrr_cat; pfam04471 405566000099 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 405566000100 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761 405566000101 DNA binding residues [nucleotide binding] 405566000102 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 405566000103 catalytic residues [active] 405566000104 catalytic nucleophile [active] 405566000105 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566000106 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405566000107 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 405566000108 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 405566000109 Predicted membrane protein [Function unknown]; Region: COG4905 405566000110 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 405566000111 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 405566000112 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 405566000113 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 405566000114 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405566000115 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 405566000116 catalytic triad [active] 405566000117 oxyanion hole [active] 405566000118 active site 405566000119 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405566000120 catalytic core [active] 405566000121 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 405566000122 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405566000123 catalytic residue [active] 405566000124 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 405566000125 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 405566000126 putative ligand binding site [chemical binding]; other site 405566000127 putative NAD binding site [chemical binding]; other site 405566000128 putative catalytic site [active] 405566000129 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 405566000130 L-serine binding site [chemical binding]; other site 405566000131 ACT domain interface; other site 405566000132 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405566000133 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 405566000134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405566000135 Walker A/P-loop; other site 405566000136 ATP binding site [chemical binding]; other site 405566000137 Q-loop/lid; other site 405566000138 ABC transporter signature motif; other site 405566000139 Walker B; other site 405566000140 D-loop; other site 405566000141 H-loop/switch region; other site 405566000142 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 405566000143 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405566000144 TM-ABC transporter signature motif; other site 405566000145 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 405566000146 zinc binding site [ion binding]; other site 405566000147 putative ligand binding site [chemical binding]; other site 405566000148 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 405566000149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405566000150 motif II; other site 405566000151 Bacterial surface layer protein; Region: SLAP; pfam03217 405566000152 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405566000153 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405566000154 active site 405566000155 catalytic tetrad [active] 405566000156 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 405566000157 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 405566000158 G1 box; other site 405566000159 putative GEF interaction site [polypeptide binding]; other site 405566000160 GTP/Mg2+ binding site [chemical binding]; other site 405566000161 Switch I region; other site 405566000162 G2 box; other site 405566000163 G3 box; other site 405566000164 Switch II region; other site 405566000165 G4 box; other site 405566000166 G5 box; other site 405566000167 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 405566000168 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 405566000169 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 405566000170 D-lactate dehydrogenase; Validated; Region: PRK08605 405566000171 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 405566000172 homodimer interface [polypeptide binding]; other site 405566000173 ligand binding site [chemical binding]; other site 405566000174 NAD binding site [chemical binding]; other site 405566000175 catalytic site [active] 405566000176 Fructosamine kinase; Region: Fructosamin_kin; cl17579 405566000177 Phosphotransferase enzyme family; Region: APH; pfam01636 405566000178 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 405566000179 active site 405566000180 putative catalytic site [active] 405566000181 DNA binding site [nucleotide binding] 405566000182 putative phosphate binding site [ion binding]; other site 405566000183 metal binding site A [ion binding]; metal-binding site 405566000184 AP binding site [nucleotide binding]; other site 405566000185 metal binding site B [ion binding]; metal-binding site 405566000186 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 405566000187 PLD-like domain; Region: PLDc_2; pfam13091 405566000188 putative homodimer interface [polypeptide binding]; other site 405566000189 putative active site [active] 405566000190 catalytic site [active] 405566000191 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 405566000192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405566000193 ATP binding site [chemical binding]; other site 405566000194 putative Mg++ binding site [ion binding]; other site 405566000195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405566000196 nucleotide binding region [chemical binding]; other site 405566000197 ATP-binding site [chemical binding]; other site 405566000198 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 405566000199 Beta-lactamase; Region: Beta-lactamase; pfam00144 405566000200 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405566000201 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 405566000202 active site 405566000203 catalytic residues [active] 405566000204 metal binding site [ion binding]; metal-binding site 405566000205 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405566000206 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405566000207 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 405566000208 dimerization interface [polypeptide binding]; other site 405566000209 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 405566000210 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 405566000211 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 405566000212 putative acyl-acceptor binding pocket; other site 405566000213 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 405566000214 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 405566000215 Ligand binding site; other site 405566000216 metal-binding site 405566000217 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 405566000218 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 405566000219 Ligand binding site; other site 405566000220 metal-binding site 405566000221 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405566000222 active site 405566000223 Helix-turn-helix domain; Region: HTH_19; pfam12844 405566000224 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 405566000225 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 405566000226 putative acyl-acceptor binding pocket; other site 405566000227 Bacterial surface layer protein; Region: SLAP; pfam03217 405566000228 Peptidase family M48; Region: Peptidase_M48; cl12018 405566000229 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405566000230 non-specific DNA binding site [nucleotide binding]; other site 405566000231 salt bridge; other site 405566000232 sequence-specific DNA binding site [nucleotide binding]; other site 405566000233 Bacterial surface layer protein; Region: SLAP; pfam03217 405566000234 Bacterial surface layer protein; Region: SLAP; pfam03217 405566000235 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566000236 MULE transposase domain; Region: MULE; pfam10551 405566000237 Bacterial surface layer protein; Region: SLAP; pfam03217 405566000238 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405566000239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405566000240 active site 405566000241 phosphorylation site [posttranslational modification] 405566000242 intermolecular recognition site; other site 405566000243 dimerization interface [polypeptide binding]; other site 405566000244 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405566000245 DNA binding site [nucleotide binding] 405566000246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 405566000247 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405566000248 dimerization interface [polypeptide binding]; other site 405566000249 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405566000250 putative active site [active] 405566000251 heme pocket [chemical binding]; other site 405566000252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405566000253 dimer interface [polypeptide binding]; other site 405566000254 phosphorylation site [posttranslational modification] 405566000255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405566000256 ATP binding site [chemical binding]; other site 405566000257 Mg2+ binding site [ion binding]; other site 405566000258 G-X-G motif; other site 405566000259 YycH protein; Region: YycH; pfam07435 405566000260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 405566000261 YycH protein; Region: YycI; pfam09648 405566000262 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 405566000263 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 405566000264 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405566000265 protein binding site [polypeptide binding]; other site 405566000266 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 405566000267 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 405566000268 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 405566000269 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405566000270 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405566000271 Walker A/P-loop; other site 405566000272 ATP binding site [chemical binding]; other site 405566000273 Q-loop/lid; other site 405566000274 ABC transporter signature motif; other site 405566000275 Walker B; other site 405566000276 D-loop; other site 405566000277 H-loop/switch region; other site 405566000278 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405566000279 Walker A/P-loop; other site 405566000280 ATP binding site [chemical binding]; other site 405566000281 ABC transporter; Region: ABC_tran; pfam00005 405566000282 Q-loop/lid; other site 405566000283 ABC transporter signature motif; other site 405566000284 Walker B; other site 405566000285 D-loop; other site 405566000286 H-loop/switch region; other site 405566000287 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 405566000288 Helix-turn-helix domain; Region: HTH_18; pfam12833 405566000289 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405566000290 heat shock protein HtpX; Provisional; Region: PRK04897 405566000291 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 405566000292 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 405566000293 transmembrane helices; other site 405566000294 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 405566000295 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405566000296 Zn2+ binding site [ion binding]; other site 405566000297 Mg2+ binding site [ion binding]; other site 405566000298 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 405566000299 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405566000300 active site 405566000301 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405566000302 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405566000303 Walker A/P-loop; other site 405566000304 ATP binding site [chemical binding]; other site 405566000305 Q-loop/lid; other site 405566000306 ABC transporter signature motif; other site 405566000307 Walker B; other site 405566000308 D-loop; other site 405566000309 H-loop/switch region; other site 405566000310 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405566000311 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405566000312 substrate binding pocket [chemical binding]; other site 405566000313 membrane-bound complex binding site; other site 405566000314 hinge residues; other site 405566000315 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405566000316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566000317 dimer interface [polypeptide binding]; other site 405566000318 conserved gate region; other site 405566000319 putative PBP binding loops; other site 405566000320 ABC-ATPase subunit interface; other site 405566000321 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 405566000322 active site 405566000323 DNA binding site [nucleotide binding] 405566000324 Protein of unknown function, DUF488; Region: DUF488; cl01246 405566000325 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 405566000326 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 405566000327 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 405566000328 DNA binding site [nucleotide binding] 405566000329 active site 405566000330 NAD-dependent deacetylase; Provisional; Region: PRK00481 405566000331 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 405566000332 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 405566000333 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 405566000334 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 405566000335 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405566000336 putative active site [active] 405566000337 catalytic site [active] 405566000338 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405566000339 putative active site [active] 405566000340 catalytic site [active] 405566000341 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 405566000342 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 405566000343 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 405566000344 RNA/DNA hybrid binding site [nucleotide binding]; other site 405566000345 active site 405566000346 Predicted secreted protein [Function unknown]; Region: COG4086 405566000347 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 405566000348 putative glycosyl transferase; Provisional; Region: PRK10073 405566000349 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 405566000350 active site 405566000351 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 405566000352 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405566000353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405566000354 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405566000355 NAD(P) binding site [chemical binding]; other site 405566000356 active site 405566000357 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 405566000358 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 405566000359 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405566000360 active site 405566000361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405566000362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405566000363 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405566000364 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405566000365 substrate binding pocket [chemical binding]; other site 405566000366 membrane-bound complex binding site; other site 405566000367 hinge residues; other site 405566000368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566000369 dimer interface [polypeptide binding]; other site 405566000370 conserved gate region; other site 405566000371 putative PBP binding loops; other site 405566000372 ABC-ATPase subunit interface; other site 405566000373 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405566000374 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405566000375 Walker A/P-loop; other site 405566000376 ATP binding site [chemical binding]; other site 405566000377 Q-loop/lid; other site 405566000378 ABC transporter signature motif; other site 405566000379 Walker B; other site 405566000380 D-loop; other site 405566000381 H-loop/switch region; other site 405566000382 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 405566000383 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 405566000384 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 405566000385 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405566000386 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 405566000387 DNA binding residues [nucleotide binding] 405566000388 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 405566000389 YibE/F-like protein; Region: YibE_F; pfam07907 405566000390 YibE/F-like protein; Region: YibE_F; pfam07907 405566000391 fragment of insertion sequence ISLhe2 405566000392 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 405566000393 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566000394 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566000395 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 405566000396 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 405566000397 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 405566000398 active site 405566000399 catalytic site [active] 405566000400 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 405566000401 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405566000402 Interdomain contacts; other site 405566000403 Cytokine receptor motif; other site 405566000404 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 405566000405 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405566000406 active site 405566000407 phosphorylation site [posttranslational modification] 405566000408 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 405566000409 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 405566000410 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 405566000411 Ligand Binding Site [chemical binding]; other site 405566000412 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 405566000413 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405566000414 membrane-bound complex binding site; other site 405566000415 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 405566000416 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 405566000417 Walker A/P-loop; other site 405566000418 ATP binding site [chemical binding]; other site 405566000419 Q-loop/lid; other site 405566000420 ABC transporter signature motif; other site 405566000421 Walker B; other site 405566000422 D-loop; other site 405566000423 H-loop/switch region; other site 405566000424 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 405566000425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566000426 dimer interface [polypeptide binding]; other site 405566000427 conserved gate region; other site 405566000428 putative PBP binding loops; other site 405566000429 ABC-ATPase subunit interface; other site 405566000430 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 405566000431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566000432 dimer interface [polypeptide binding]; other site 405566000433 conserved gate region; other site 405566000434 putative PBP binding loops; other site 405566000435 ABC-ATPase subunit interface; other site 405566000436 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 405566000437 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 405566000438 active site 405566000439 metal binding site [ion binding]; metal-binding site 405566000440 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 405566000441 active site 405566000442 dimer interface [polypeptide binding]; other site 405566000443 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 405566000444 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 405566000445 Ligand Binding Site [chemical binding]; other site 405566000446 Molecular Tunnel; other site 405566000447 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 405566000448 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 405566000449 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 405566000450 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 405566000451 ATP cone domain; Region: ATP-cone; pfam03477 405566000452 Class III ribonucleotide reductase; Region: RNR_III; cd01675 405566000453 effector binding site; other site 405566000454 active site 405566000455 Zn binding site [ion binding]; other site 405566000456 glycine loop; other site 405566000457 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 405566000458 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 405566000459 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 405566000460 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 405566000461 Uncharacterized conserved protein [Function unknown]; Region: COG2461 405566000462 Family of unknown function (DUF438); Region: DUF438; pfam04282 405566000463 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 405566000464 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405566000465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405566000466 putative substrate translocation pore; other site 405566000467 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 405566000468 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 405566000469 active site 405566000470 Zn binding site [ion binding]; other site 405566000471 K+ potassium transporter; Region: K_trans; pfam02705 405566000472 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 405566000473 Probable transposase; Region: OrfB_IS605; pfam01385 405566000474 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566000475 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405566000476 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 405566000477 Bacterial surface layer protein; Region: SLAP; pfam03217 405566000478 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 405566000479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 405566000480 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 405566000481 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 405566000482 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 405566000483 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 405566000484 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 405566000485 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 405566000486 Bacterial surface layer protein; Region: SLAP; pfam03217 405566000487 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405566000488 amidase catalytic site [active] 405566000489 Zn binding residues [ion binding]; other site 405566000490 substrate binding site [chemical binding]; other site 405566000491 Bacterial surface layer protein; Region: SLAP; pfam03217 405566000492 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405566000493 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405566000494 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 405566000495 TrkA-N domain; Region: TrkA_N; pfam02254 405566000496 TrkA-C domain; Region: TrkA_C; pfam02080 405566000497 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 405566000498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405566000499 non-specific DNA binding site [nucleotide binding]; other site 405566000500 salt bridge; other site 405566000501 sequence-specific DNA binding site [nucleotide binding]; other site 405566000502 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 405566000503 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 405566000504 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405566000505 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 405566000506 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405566000507 catalytic core [active] 405566000508 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405566000509 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 405566000510 putative substrate binding pocket [chemical binding]; other site 405566000511 AC domain interface; other site 405566000512 catalytic triad [active] 405566000513 AB domain interface; other site 405566000514 interchain disulfide; other site 405566000515 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 405566000516 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 405566000517 membrane protein; Provisional; Region: PRK14411 405566000518 Sulfatase; Region: Sulfatase; cl17466 405566000519 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405566000520 Interdomain contacts; other site 405566000521 Cytokine receptor motif; other site 405566000522 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 405566000523 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 405566000524 active site 405566000525 HIGH motif; other site 405566000526 dimer interface [polypeptide binding]; other site 405566000527 KMSKS motif; other site 405566000528 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405566000529 RNA binding surface [nucleotide binding]; other site 405566000530 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 405566000531 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761 405566000532 DNA binding residues [nucleotide binding] 405566000533 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 405566000534 catalytic residues [active] 405566000535 catalytic nucleophile [active] 405566000536 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566000537 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405566000538 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 405566000539 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 405566000540 trimer interface [polypeptide binding]; other site 405566000541 active site 405566000542 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 405566000543 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 405566000544 Zn2+ binding site [ion binding]; other site 405566000545 Mg2+ binding site [ion binding]; other site 405566000546 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405566000547 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405566000548 peptide binding site [polypeptide binding]; other site 405566000549 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405566000550 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405566000551 peptide binding site [polypeptide binding]; other site 405566000552 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 405566000553 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 405566000554 active site 405566000555 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405566000556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566000557 dimer interface [polypeptide binding]; other site 405566000558 conserved gate region; other site 405566000559 putative PBP binding loops; other site 405566000560 ABC-ATPase subunit interface; other site 405566000561 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405566000562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566000563 dimer interface [polypeptide binding]; other site 405566000564 conserved gate region; other site 405566000565 putative PBP binding loops; other site 405566000566 ABC-ATPase subunit interface; other site 405566000567 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405566000568 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405566000569 Walker A/P-loop; other site 405566000570 ATP binding site [chemical binding]; other site 405566000571 Q-loop/lid; other site 405566000572 ABC transporter signature motif; other site 405566000573 Walker B; other site 405566000574 D-loop; other site 405566000575 H-loop/switch region; other site 405566000576 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 405566000577 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 405566000578 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405566000579 Walker A/P-loop; other site 405566000580 ATP binding site [chemical binding]; other site 405566000581 Q-loop/lid; other site 405566000582 ABC transporter signature motif; other site 405566000583 Walker B; other site 405566000584 D-loop; other site 405566000585 H-loop/switch region; other site 405566000586 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 405566000587 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 405566000588 trimer interface [polypeptide binding]; other site 405566000589 active site 405566000590 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 405566000591 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 405566000592 putative dimer interface [polypeptide binding]; other site 405566000593 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 405566000594 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 405566000595 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 405566000596 CAAX protease self-immunity; Region: Abi; pfam02517 405566000597 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 405566000598 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 405566000599 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 405566000600 active site 405566000601 HIGH motif; other site 405566000602 dimer interface [polypeptide binding]; other site 405566000603 KMSKS motif; other site 405566000604 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 405566000605 catalytic motif [active] 405566000606 Zn binding site [ion binding]; other site 405566000607 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 405566000608 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 405566000609 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405566000610 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 405566000611 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 405566000612 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 405566000613 active site 405566000614 HIGH motif; other site 405566000615 KMSKS motif; other site 405566000616 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 405566000617 tRNA binding surface [nucleotide binding]; other site 405566000618 anticodon binding site; other site 405566000619 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 405566000620 dimer interface [polypeptide binding]; other site 405566000621 putative tRNA-binding site [nucleotide binding]; other site 405566000622 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 405566000623 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 405566000624 active site 405566000625 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 405566000626 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 405566000627 putative active site [active] 405566000628 putative metal binding site [ion binding]; other site 405566000629 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 405566000630 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 405566000631 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 405566000632 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 405566000633 pur operon repressor; Provisional; Region: PRK09213 405566000634 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 405566000635 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405566000636 active site 405566000637 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 405566000638 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 405566000639 Substrate binding site; other site 405566000640 Mg++ binding site; other site 405566000641 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 405566000642 active site 405566000643 substrate binding site [chemical binding]; other site 405566000644 CoA binding site [chemical binding]; other site 405566000645 Bacterial surface layer protein; Region: SLAP; pfam03217 405566000646 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 405566000647 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 405566000648 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405566000649 active site 405566000650 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 405566000651 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405566000652 Zn2+ binding site [ion binding]; other site 405566000653 Mg2+ binding site [ion binding]; other site 405566000654 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 405566000655 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 405566000656 CTP synthetase; Validated; Region: pyrG; PRK05380 405566000657 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 405566000658 Catalytic site [active] 405566000659 active site 405566000660 UTP binding site [chemical binding]; other site 405566000661 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 405566000662 active site 405566000663 putative oxyanion hole; other site 405566000664 catalytic triad [active] 405566000665 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 405566000666 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 405566000667 hinge; other site 405566000668 active site 405566000669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405566000670 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 405566000671 motif II; other site 405566000672 Peptidase family C69; Region: Peptidase_C69; pfam03577 405566000673 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 405566000674 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405566000675 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405566000676 xanthine permease; Region: pbuX; TIGR03173 405566000677 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405566000678 active site 405566000679 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405566000680 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405566000681 Probable transposase; Region: OrfB_IS605; pfam01385 405566000682 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566000683 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 405566000684 GMP synthase; Reviewed; Region: guaA; PRK00074 405566000685 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 405566000686 AMP/PPi binding site [chemical binding]; other site 405566000687 candidate oxyanion hole; other site 405566000688 catalytic triad [active] 405566000689 potential glutamine specificity residues [chemical binding]; other site 405566000690 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 405566000691 ATP Binding subdomain [chemical binding]; other site 405566000692 Ligand Binding sites [chemical binding]; other site 405566000693 Dimerization subdomain; other site 405566000694 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 405566000695 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 405566000696 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566000697 MULE transposase domain; Region: MULE; pfam10551 405566000698 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 405566000699 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566000700 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566000701 fragment of insertion sequence ISLhe63 405566000702 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405566000703 non-specific DNA binding site [nucleotide binding]; other site 405566000704 salt bridge; other site 405566000705 sequence-specific DNA binding site [nucleotide binding]; other site 405566000706 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 405566000707 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566000708 MULE transposase domain; Region: MULE; pfam10551 405566000709 Bacterial surface layer protein; Region: SLAP; pfam03217 405566000710 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405566000711 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405566000712 Probable transposase; Region: OrfB_IS605; pfam01385 405566000713 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566000714 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405566000715 Eukaryotic phosphomannomutase; Region: PMM; cl17107 405566000716 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405566000717 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 405566000718 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 405566000719 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405566000720 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405566000721 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405566000722 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405566000723 ATP binding site [chemical binding]; other site 405566000724 Mg++ binding site [ion binding]; other site 405566000725 motif III; other site 405566000726 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405566000727 nucleotide binding region [chemical binding]; other site 405566000728 ATP-binding site [chemical binding]; other site 405566000729 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 405566000730 alanine racemase; Reviewed; Region: alr; PRK00053 405566000731 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 405566000732 active site 405566000733 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405566000734 dimer interface [polypeptide binding]; other site 405566000735 substrate binding site [chemical binding]; other site 405566000736 catalytic residues [active] 405566000737 FOG: CBS domain [General function prediction only]; Region: COG0517 405566000738 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 405566000739 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 405566000740 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 405566000741 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405566000742 NAD binding site [chemical binding]; other site 405566000743 dimer interface [polypeptide binding]; other site 405566000744 substrate binding site [chemical binding]; other site 405566000745 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 405566000746 putative active site [active] 405566000747 catalytic residue [active] 405566000748 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 405566000749 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 405566000750 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405566000751 ATP binding site [chemical binding]; other site 405566000752 putative Mg++ binding site [ion binding]; other site 405566000753 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405566000754 nucleotide binding region [chemical binding]; other site 405566000755 ATP-binding site [chemical binding]; other site 405566000756 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 405566000757 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405566000758 RNA binding surface [nucleotide binding]; other site 405566000759 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 405566000760 Septum formation initiator; Region: DivIC; pfam04977 405566000761 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 405566000762 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 405566000763 RNA binding site [nucleotide binding]; other site 405566000764 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 405566000765 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 405566000766 Ligand Binding Site [chemical binding]; other site 405566000767 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 405566000768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405566000769 Walker A motif; other site 405566000770 ATP binding site [chemical binding]; other site 405566000771 Walker B motif; other site 405566000772 arginine finger; other site 405566000773 Peptidase family M41; Region: Peptidase_M41; pfam01434 405566000774 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 405566000775 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 405566000776 dimerization interface [polypeptide binding]; other site 405566000777 domain crossover interface; other site 405566000778 redox-dependent activation switch; other site 405566000779 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 405566000780 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 405566000781 FMN binding site [chemical binding]; other site 405566000782 active site 405566000783 catalytic residues [active] 405566000784 substrate binding site [chemical binding]; other site 405566000785 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 405566000786 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 405566000787 dimer interface [polypeptide binding]; other site 405566000788 putative anticodon binding site; other site 405566000789 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 405566000790 motif 1; other site 405566000791 active site 405566000792 motif 2; other site 405566000793 motif 3; other site 405566000794 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 405566000795 GAF domain; Region: GAF_2; pfam13185 405566000796 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 405566000797 Clp amino terminal domain; Region: Clp_N; pfam02861 405566000798 Clp amino terminal domain; Region: Clp_N; pfam02861 405566000799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405566000800 Walker A motif; other site 405566000801 ATP binding site [chemical binding]; other site 405566000802 Walker B motif; other site 405566000803 arginine finger; other site 405566000804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405566000805 Walker A motif; other site 405566000806 ATP binding site [chemical binding]; other site 405566000807 Walker B motif; other site 405566000808 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 405566000809 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 405566000810 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 405566000811 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 405566000812 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 405566000813 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 405566000814 RPB1 interaction site [polypeptide binding]; other site 405566000815 RPB10 interaction site [polypeptide binding]; other site 405566000816 RPB11 interaction site [polypeptide binding]; other site 405566000817 RPB3 interaction site [polypeptide binding]; other site 405566000818 RPB12 interaction site [polypeptide binding]; other site 405566000819 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 405566000820 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 405566000821 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 405566000822 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 405566000823 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 405566000824 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 405566000825 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 405566000826 G-loop; other site 405566000827 DNA binding site [nucleotide binding] 405566000828 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 405566000829 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 405566000830 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 405566000831 S17 interaction site [polypeptide binding]; other site 405566000832 S8 interaction site; other site 405566000833 16S rRNA interaction site [nucleotide binding]; other site 405566000834 streptomycin interaction site [chemical binding]; other site 405566000835 23S rRNA interaction site [nucleotide binding]; other site 405566000836 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 405566000837 30S ribosomal protein S7; Validated; Region: PRK05302 405566000838 elongation factor G; Reviewed; Region: PRK12739 405566000839 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 405566000840 G1 box; other site 405566000841 putative GEF interaction site [polypeptide binding]; other site 405566000842 GTP/Mg2+ binding site [chemical binding]; other site 405566000843 Switch I region; other site 405566000844 G2 box; other site 405566000845 G3 box; other site 405566000846 Switch II region; other site 405566000847 G4 box; other site 405566000848 G5 box; other site 405566000849 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 405566000850 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 405566000851 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 405566000852 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 405566000853 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 405566000854 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 405566000855 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 405566000856 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 405566000857 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 405566000858 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 405566000859 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 405566000860 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 405566000861 putative translocon binding site; other site 405566000862 protein-rRNA interface [nucleotide binding]; other site 405566000863 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 405566000864 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 405566000865 G-X-X-G motif; other site 405566000866 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 405566000867 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 405566000868 23S rRNA interface [nucleotide binding]; other site 405566000869 5S rRNA interface [nucleotide binding]; other site 405566000870 putative antibiotic binding site [chemical binding]; other site 405566000871 L25 interface [polypeptide binding]; other site 405566000872 L27 interface [polypeptide binding]; other site 405566000873 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 405566000874 23S rRNA interface [nucleotide binding]; other site 405566000875 putative translocon interaction site; other site 405566000876 signal recognition particle (SRP54) interaction site; other site 405566000877 L23 interface [polypeptide binding]; other site 405566000878 trigger factor interaction site; other site 405566000879 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 405566000880 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 405566000881 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 405566000882 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 405566000883 RNA binding site [nucleotide binding]; other site 405566000884 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 405566000885 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 405566000886 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 405566000887 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 405566000888 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 405566000889 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 405566000890 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 405566000891 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 405566000892 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 405566000893 23S rRNA interface [nucleotide binding]; other site 405566000894 L21e interface [polypeptide binding]; other site 405566000895 5S rRNA interface [nucleotide binding]; other site 405566000896 L27 interface [polypeptide binding]; other site 405566000897 L5 interface [polypeptide binding]; other site 405566000898 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 405566000899 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 405566000900 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 405566000901 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 405566000902 23S rRNA binding site [nucleotide binding]; other site 405566000903 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 405566000904 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 405566000905 SecY translocase; Region: SecY; pfam00344 405566000906 adenylate kinase; Reviewed; Region: adk; PRK00279 405566000907 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 405566000908 AMP-binding site [chemical binding]; other site 405566000909 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 405566000910 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 405566000911 rRNA binding site [nucleotide binding]; other site 405566000912 predicted 30S ribosome binding site; other site 405566000913 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 405566000914 30S ribosomal protein S13; Region: bact_S13; TIGR03631 405566000915 30S ribosomal protein S11; Validated; Region: PRK05309 405566000916 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 405566000917 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 405566000918 alphaNTD homodimer interface [polypeptide binding]; other site 405566000919 alphaNTD - beta interaction site [polypeptide binding]; other site 405566000920 alphaNTD - beta' interaction site [polypeptide binding]; other site 405566000921 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 405566000922 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 405566000923 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13640 405566000924 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405566000925 Walker A/P-loop; other site 405566000926 ATP binding site [chemical binding]; other site 405566000927 Q-loop/lid; other site 405566000928 ABC transporter signature motif; other site 405566000929 Walker B; other site 405566000930 D-loop; other site 405566000931 H-loop/switch region; other site 405566000932 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13641 405566000933 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405566000934 Walker A/P-loop; other site 405566000935 ATP binding site [chemical binding]; other site 405566000936 Q-loop/lid; other site 405566000937 ABC transporter signature motif; other site 405566000938 Walker B; other site 405566000939 D-loop; other site 405566000940 H-loop/switch region; other site 405566000941 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 405566000942 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 405566000943 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 405566000944 dimerization interface 3.5A [polypeptide binding]; other site 405566000945 active site 405566000946 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 405566000947 23S rRNA interface [nucleotide binding]; other site 405566000948 L3 interface [polypeptide binding]; other site 405566000949 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 405566000950 Transposase; Region: DEDD_Tnp_IS110; pfam01548 405566000951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 405566000952 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 405566000953 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566000954 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566000955 Protein of unknown function (DUF805); Region: DUF805; pfam05656 405566000956 DJ-1 family protein; Region: not_thiJ; TIGR01383 405566000957 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 405566000958 conserved cys residue [active] 405566000959 hypothetical protein; Provisional; Region: PRK10621 405566000960 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405566000961 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405566000962 catalytic core [active] 405566000963 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 405566000964 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 405566000965 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405566000966 catalytic core [active] 405566000967 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405566000968 AAA domain; Region: AAA_33; pfam13671 405566000969 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566000970 MULE transposase domain; Region: MULE; pfam10551 405566000971 magnesium-transporting ATPase; Provisional; Region: PRK15122 405566000972 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 405566000973 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405566000974 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 405566000975 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405566000976 motif II; other site 405566000977 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 405566000978 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 405566000979 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 405566000980 trimer interface [polypeptide binding]; other site 405566000981 active site 405566000982 G bulge; other site 405566000983 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566000984 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 405566000985 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405566000986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405566000987 Probable transposase; Region: OrfB_IS605; pfam01385 405566000988 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566000989 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 405566000990 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 405566000991 trimer interface [polypeptide binding]; other site 405566000992 active site 405566000993 DNA repair protein RadA; Provisional; Region: PRK11823 405566000994 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 405566000995 Walker A motif/ATP binding site; other site 405566000996 ATP binding site [chemical binding]; other site 405566000997 Walker B motif; other site 405566000998 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 405566000999 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 405566001000 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 405566001001 active site 405566001002 HIGH motif; other site 405566001003 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 405566001004 active site 405566001005 KMSKS motif; other site 405566001006 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 405566001007 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 405566001008 active site 405566001009 HIGH motif; other site 405566001010 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 405566001011 KMSKS motif; other site 405566001012 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 405566001013 tRNA binding surface [nucleotide binding]; other site 405566001014 anticodon binding site; other site 405566001015 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 405566001016 active site 405566001017 metal binding site [ion binding]; metal-binding site 405566001018 dimerization interface [polypeptide binding]; other site 405566001019 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 405566001020 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 405566001021 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 405566001022 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 405566001023 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 405566001024 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 405566001025 N- and C-terminal domain interface [polypeptide binding]; other site 405566001026 active site 405566001027 catalytic site [active] 405566001028 metal binding site [ion binding]; metal-binding site 405566001029 carbohydrate binding site [chemical binding]; other site 405566001030 ATP binding site [chemical binding]; other site 405566001031 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 405566001032 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 405566001033 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 405566001034 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 405566001035 putative homodimer interface [polypeptide binding]; other site 405566001036 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 405566001037 heterodimer interface [polypeptide binding]; other site 405566001038 homodimer interface [polypeptide binding]; other site 405566001039 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 405566001040 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 405566001041 23S rRNA interface [nucleotide binding]; other site 405566001042 L7/L12 interface [polypeptide binding]; other site 405566001043 putative thiostrepton binding site; other site 405566001044 L25 interface [polypeptide binding]; other site 405566001045 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 405566001046 mRNA/rRNA interface [nucleotide binding]; other site 405566001047 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566001048 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566001049 PBP superfamily domain; Region: PBP_like_2; cl17296 405566001050 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 405566001051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566001052 dimer interface [polypeptide binding]; other site 405566001053 conserved gate region; other site 405566001054 putative PBP binding loops; other site 405566001055 ABC-ATPase subunit interface; other site 405566001056 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 405566001057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566001058 dimer interface [polypeptide binding]; other site 405566001059 conserved gate region; other site 405566001060 putative PBP binding loops; other site 405566001061 ABC-ATPase subunit interface; other site 405566001062 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 405566001063 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 405566001064 Walker A/P-loop; other site 405566001065 ATP binding site [chemical binding]; other site 405566001066 Q-loop/lid; other site 405566001067 ABC transporter signature motif; other site 405566001068 Walker B; other site 405566001069 D-loop; other site 405566001070 H-loop/switch region; other site 405566001071 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14251 405566001072 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 405566001073 Walker A/P-loop; other site 405566001074 ATP binding site [chemical binding]; other site 405566001075 Q-loop/lid; other site 405566001076 ABC transporter signature motif; other site 405566001077 Walker B; other site 405566001078 D-loop; other site 405566001079 H-loop/switch region; other site 405566001080 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 405566001081 PhoU domain; Region: PhoU; pfam01895 405566001082 PhoU domain; Region: PhoU; pfam01895 405566001083 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 405566001084 23S rRNA interface [nucleotide binding]; other site 405566001085 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 405566001086 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 405566001087 core dimer interface [polypeptide binding]; other site 405566001088 peripheral dimer interface [polypeptide binding]; other site 405566001089 L10 interface [polypeptide binding]; other site 405566001090 L11 interface [polypeptide binding]; other site 405566001091 putative EF-Tu interaction site [polypeptide binding]; other site 405566001092 putative EF-G interaction site [polypeptide binding]; other site 405566001093 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 405566001094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405566001095 S-adenosylmethionine binding site [chemical binding]; other site 405566001096 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 405566001097 nucleoside/Zn binding site; other site 405566001098 dimer interface [polypeptide binding]; other site 405566001099 catalytic motif [active] 405566001100 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 405566001101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405566001102 Walker A motif; other site 405566001103 ATP binding site [chemical binding]; other site 405566001104 Walker B motif; other site 405566001105 hypothetical protein; Validated; Region: PRK00153 405566001106 recombination protein RecR; Reviewed; Region: recR; PRK00076 405566001107 RecR protein; Region: RecR; pfam02132 405566001108 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 405566001109 putative active site [active] 405566001110 putative metal-binding site [ion binding]; other site 405566001111 tetramer interface [polypeptide binding]; other site 405566001112 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 405566001113 thymidylate kinase; Validated; Region: tmk; PRK00698 405566001114 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 405566001115 TMP-binding site; other site 405566001116 ATP-binding site [chemical binding]; other site 405566001117 Protein of unknown function (DUF970); Region: DUF970; cl17525 405566001118 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 405566001119 DNA polymerase III subunit delta'; Validated; Region: PRK08485 405566001120 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 405566001121 Predicted methyltransferases [General function prediction only]; Region: COG0313 405566001122 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 405566001123 putative SAM binding site [chemical binding]; other site 405566001124 putative homodimer interface [polypeptide binding]; other site 405566001125 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 405566001126 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 405566001127 active site 405566001128 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 405566001129 active site 2 [active] 405566001130 active site 1 [active] 405566001131 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 405566001132 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 405566001133 Glycoprotease family; Region: Peptidase_M22; pfam00814 405566001134 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 405566001135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405566001136 Coenzyme A binding pocket [chemical binding]; other site 405566001137 UGMP family protein; Validated; Region: PRK09604 405566001138 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 405566001139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566001140 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566001141 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405566001142 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405566001143 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405566001144 ABC transporter; Region: ABC_tran_2; pfam12848 405566001145 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405566001146 ABC transporter; Region: ABC_tran_2; pfam12848 405566001147 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 405566001148 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 405566001149 CoA binding domain; Region: CoA_binding; pfam02629 405566001150 LytTr DNA-binding domain; Region: LytTR; smart00850 405566001151 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 405566001152 HPr interaction site; other site 405566001153 glycerol kinase (GK) interaction site [polypeptide binding]; other site 405566001154 active site 405566001155 phosphorylation site [posttranslational modification] 405566001156 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 405566001157 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 405566001158 oligomerisation interface [polypeptide binding]; other site 405566001159 mobile loop; other site 405566001160 roof hairpin; other site 405566001161 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 405566001162 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 405566001163 ring oligomerisation interface [polypeptide binding]; other site 405566001164 ATP/Mg binding site [chemical binding]; other site 405566001165 stacking interactions; other site 405566001166 hinge regions; other site 405566001167 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 405566001168 MutS domain I; Region: MutS_I; pfam01624 405566001169 MutS domain II; Region: MutS_II; pfam05188 405566001170 MutS domain III; Region: MutS_III; pfam05192 405566001171 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 405566001172 Walker A/P-loop; other site 405566001173 ATP binding site [chemical binding]; other site 405566001174 Q-loop/lid; other site 405566001175 ABC transporter signature motif; other site 405566001176 Walker B; other site 405566001177 D-loop; other site 405566001178 H-loop/switch region; other site 405566001179 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 405566001180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405566001181 ATP binding site [chemical binding]; other site 405566001182 Mg2+ binding site [ion binding]; other site 405566001183 G-X-G motif; other site 405566001184 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 405566001185 ATP binding site [chemical binding]; other site 405566001186 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 405566001187 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 405566001188 RuvA N terminal domain; Region: RuvA_N; pfam01330 405566001189 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 405566001190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405566001191 Walker A motif; other site 405566001192 ATP binding site [chemical binding]; other site 405566001193 Walker B motif; other site 405566001194 arginine finger; other site 405566001195 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 405566001196 Preprotein translocase subunit; Region: YajC; pfam02699 405566001197 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 405566001198 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 405566001199 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 405566001200 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 405566001201 active site 405566001202 DNA polymerase IV; Validated; Region: PRK02406 405566001203 DNA binding site [nucleotide binding] 405566001204 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 405566001205 DHH family; Region: DHH; pfam01368 405566001206 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 405566001207 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405566001208 ATP binding site [chemical binding]; other site 405566001209 putative Mg++ binding site [ion binding]; other site 405566001210 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405566001211 nucleotide binding region [chemical binding]; other site 405566001212 ATP-binding site [chemical binding]; other site 405566001213 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 405566001214 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 405566001215 motif 1; other site 405566001216 active site 405566001217 motif 2; other site 405566001218 motif 3; other site 405566001219 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405566001220 DHHA1 domain; Region: DHHA1; pfam02272 405566001221 hypothetical protein; Provisional; Region: PRK05473 405566001222 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 405566001223 hypothetical protein; Provisional; Region: PRK13678 405566001224 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 405566001225 MutS domain III; Region: MutS_III; pfam05192 405566001226 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 405566001227 Walker A/P-loop; other site 405566001228 ATP binding site [chemical binding]; other site 405566001229 Q-loop/lid; other site 405566001230 ABC transporter signature motif; other site 405566001231 Walker B; other site 405566001232 D-loop; other site 405566001233 H-loop/switch region; other site 405566001234 Smr domain; Region: Smr; pfam01713 405566001235 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 405566001236 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405566001237 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 405566001238 catalytic residues [active] 405566001239 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 405566001240 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 405566001241 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566001242 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 405566001243 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405566001244 Helix-turn-helix domain; Region: HTH_28; pfam13518 405566001245 putative transposase OrfB; Reviewed; Region: PHA02517 405566001246 HTH-like domain; Region: HTH_21; pfam13276 405566001247 Integrase core domain; Region: rve; pfam00665 405566001248 Integrase core domain; Region: rve_2; pfam13333 405566001249 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 405566001250 glutamate racemase; Provisional; Region: PRK00865 405566001251 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 405566001252 active site 405566001253 dimerization interface [polypeptide binding]; other site 405566001254 Transposase; Region: DEDD_Tnp_IS110; pfam01548 405566001255 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 405566001256 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 405566001257 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566001258 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566001259 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 405566001260 Mechanosensitive ion channel; Region: MS_channel; pfam00924 405566001261 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 405566001262 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 405566001263 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 405566001264 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 405566001265 active site 405566001266 catabolite control protein A; Region: ccpA; TIGR01481 405566001267 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405566001268 DNA binding site [nucleotide binding] 405566001269 domain linker motif; other site 405566001270 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 405566001271 dimerization interface [polypeptide binding]; other site 405566001272 effector binding site; other site 405566001273 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405566001274 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 405566001275 active site 405566001276 catalytic site [active] 405566001277 metal binding site [ion binding]; metal-binding site 405566001278 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405566001279 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 405566001280 active site 405566001281 metal binding site [ion binding]; metal-binding site 405566001282 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405566001283 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 405566001284 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 405566001285 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405566001286 active site 405566001287 motif I; other site 405566001288 motif II; other site 405566001289 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405566001290 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 405566001291 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 405566001292 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405566001293 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 405566001294 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405566001295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405566001296 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405566001297 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 405566001298 putative ADP-binding pocket [chemical binding]; other site 405566001299 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405566001300 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 405566001301 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 405566001302 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 405566001303 Sulfatase; Region: Sulfatase; pfam00884 405566001304 Preprotein translocase SecG subunit; Region: SecG; cl09123 405566001305 ribonuclease R; Region: RNase_R; TIGR02063 405566001306 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 405566001307 RNB domain; Region: RNB; pfam00773 405566001308 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 405566001309 RNA binding site [nucleotide binding]; other site 405566001310 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 405566001311 SmpB-tmRNA interface; other site 405566001312 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 405566001313 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405566001314 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405566001315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405566001316 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 405566001317 HPr interaction site; other site 405566001318 glycerol kinase (GK) interaction site [polypeptide binding]; other site 405566001319 active site 405566001320 phosphorylation site [posttranslational modification] 405566001321 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 405566001322 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 405566001323 active pocket/dimerization site; other site 405566001324 active site 405566001325 phosphorylation site [posttranslational modification] 405566001326 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 405566001327 active site 405566001328 phosphorylation site [posttranslational modification] 405566001329 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 405566001330 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 405566001331 Domain of unknown function (DUF956); Region: DUF956; pfam06115 405566001332 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 405566001333 putative trimer interface [polypeptide binding]; other site 405566001334 putative CoA binding site [chemical binding]; other site 405566001335 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 405566001336 Spore germination protein; Region: Spore_permease; cl17796 405566001337 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 405566001338 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 405566001339 glutaminase active site [active] 405566001340 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 405566001341 dimer interface [polypeptide binding]; other site 405566001342 active site 405566001343 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 405566001344 dimer interface [polypeptide binding]; other site 405566001345 active site 405566001346 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 405566001347 MucBP domain; Region: MucBP; pfam06458 405566001348 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 405566001349 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 405566001350 propionate/acetate kinase; Provisional; Region: PRK12379 405566001351 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 405566001352 active site 405566001353 Ap4A binding cleft/pocket [chemical binding]; other site 405566001354 P4 phosphate binding site; other site 405566001355 nudix motif; other site 405566001356 putative P2/P3 phosphate binding site [ion binding]; other site 405566001357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405566001358 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405566001359 Probable transposase; Region: OrfB_IS605; pfam01385 405566001360 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566001361 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 405566001362 TIGR02452 family protein; Region: TIGR02452 405566001363 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 405566001364 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566001365 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 405566001366 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 405566001367 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405566001368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405566001369 DNA-binding site [nucleotide binding]; DNA binding site 405566001370 UTRA domain; Region: UTRA; pfam07702 405566001371 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 405566001372 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 405566001373 active site 405566001374 dimer interface [polypeptide binding]; other site 405566001375 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 405566001376 Probable transposase; Region: OrfB_IS605; pfam01385 405566001377 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566001378 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405566001379 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 405566001380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 405566001381 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566001382 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 405566001383 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 405566001384 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405566001385 catalytic core [active] 405566001386 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405566001387 catalytic core [active] 405566001388 Uncharacterized conserved protein [Function unknown]; Region: COG1359 405566001389 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405566001390 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 405566001391 active site 405566001392 catalytic site [active] 405566001393 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 405566001394 Helix-turn-helix domain; Region: HTH_38; pfam13936 405566001395 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405566001396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405566001397 DNA-binding site [nucleotide binding]; DNA binding site 405566001398 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 405566001399 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 405566001400 active site 405566001401 nucleotide binding site [chemical binding]; other site 405566001402 HIGH motif; other site 405566001403 KMSKS motif; other site 405566001404 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 405566001405 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 405566001406 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405566001407 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 405566001408 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 405566001409 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 405566001410 active site 405566001411 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 405566001412 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 405566001413 homodimer interface [polypeptide binding]; other site 405566001414 NAD binding pocket [chemical binding]; other site 405566001415 ATP binding pocket [chemical binding]; other site 405566001416 Mg binding site [ion binding]; other site 405566001417 active-site loop [active] 405566001418 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 405566001419 Probable transposase; Region: OrfB_IS605; pfam01385 405566001420 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566001421 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405566001422 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 405566001423 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 405566001424 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 405566001425 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 405566001426 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 405566001427 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 405566001428 hypothetical protein; Provisional; Region: PRK04351 405566001429 SprT homologues; Region: SprT; cl01182 405566001430 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 405566001431 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 405566001432 Part of AAA domain; Region: AAA_19; pfam13245 405566001433 Family description; Region: UvrD_C_2; pfam13538 405566001434 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 405566001435 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 405566001436 nucleotide binding pocket [chemical binding]; other site 405566001437 K-X-D-G motif; other site 405566001438 catalytic site [active] 405566001439 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 405566001440 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 405566001441 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 405566001442 Dimer interface [polypeptide binding]; other site 405566001443 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 405566001444 putative dimer interface [polypeptide binding]; other site 405566001445 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 405566001446 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 405566001447 putative dimer interface [polypeptide binding]; other site 405566001448 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 405566001449 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 405566001450 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 405566001451 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 405566001452 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 405566001453 GatB domain; Region: GatB_Yqey; pfam02637 405566001454 putative lipid kinase; Reviewed; Region: PRK13337 405566001455 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 405566001456 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 405566001457 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 405566001458 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 405566001459 TRAM domain; Region: TRAM; cl01282 405566001460 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 405566001461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405566001462 S-adenosylmethionine binding site [chemical binding]; other site 405566001463 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 405566001464 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 405566001465 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 405566001466 transaminase; Reviewed; Region: PRK08068 405566001467 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405566001468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405566001469 homodimer interface [polypeptide binding]; other site 405566001470 catalytic residue [active] 405566001471 Predicted amidohydrolase [General function prediction only]; Region: COG0388 405566001472 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 405566001473 putative active site [active] 405566001474 catalytic triad [active] 405566001475 putative dimer interface [polypeptide binding]; other site 405566001476 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 405566001477 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 405566001478 Helix-turn-helix domain; Region: HTH_38; pfam13936 405566001479 Predicted transcriptional regulators [Transcription]; Region: COG1695 405566001480 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405566001481 putative Zn2+ binding site [ion binding]; other site 405566001482 putative DNA binding site [nucleotide binding]; other site 405566001483 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 405566001484 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 405566001485 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 405566001486 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 405566001487 Integrase core domain; Region: rve; pfam00665 405566001488 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566001489 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566001490 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405566001491 DNA-binding site [nucleotide binding]; DNA binding site 405566001492 RNA-binding motif; other site 405566001493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405566001494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405566001495 Coenzyme A binding pocket [chemical binding]; other site 405566001496 uracil transporter; Provisional; Region: PRK10720 405566001497 Sulfate transporter family; Region: Sulfate_transp; pfam00916 405566001498 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 405566001499 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405566001500 active site 405566001501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405566001502 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405566001503 putative substrate translocation pore; other site 405566001504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405566001505 drug efflux system protein MdtG; Provisional; Region: PRK09874 405566001506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405566001507 putative substrate translocation pore; other site 405566001508 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 405566001509 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 405566001510 oligomer interface [polypeptide binding]; other site 405566001511 active site 405566001512 metal binding site [ion binding]; metal-binding site 405566001513 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 405566001514 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405566001515 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405566001516 ABC transporter; Region: ABC_tran_2; pfam12848 405566001517 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405566001518 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 405566001519 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 405566001520 catalytic triad [active] 405566001521 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405566001522 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405566001523 substrate binding pocket [chemical binding]; other site 405566001524 membrane-bound complex binding site; other site 405566001525 hinge residues; other site 405566001526 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 405566001527 Transcriptional regulators [Transcription]; Region: MarR; COG1846 405566001528 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405566001529 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405566001530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405566001531 Walker A/P-loop; other site 405566001532 ATP binding site [chemical binding]; other site 405566001533 Q-loop/lid; other site 405566001534 ABC transporter signature motif; other site 405566001535 Walker B; other site 405566001536 D-loop; other site 405566001537 H-loop/switch region; other site 405566001538 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405566001539 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405566001540 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 405566001541 Walker A/P-loop; other site 405566001542 ATP binding site [chemical binding]; other site 405566001543 Q-loop/lid; other site 405566001544 ABC transporter signature motif; other site 405566001545 Walker B; other site 405566001546 D-loop; other site 405566001547 H-loop/switch region; other site 405566001548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405566001549 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 405566001550 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 405566001551 Sugar specificity; other site 405566001552 Pyrimidine base specificity; other site 405566001553 ATP-binding site [chemical binding]; other site 405566001554 fragment of insertion sequence ISLjo5 405566001555 Probable transposase; Region: OrfB_IS605; pfam01385 405566001556 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566001557 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405566001558 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405566001559 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405566001560 Walker A/P-loop; other site 405566001561 ATP binding site [chemical binding]; other site 405566001562 Q-loop/lid; other site 405566001563 ABC transporter signature motif; other site 405566001564 Walker B; other site 405566001565 D-loop; other site 405566001566 H-loop/switch region; other site 405566001567 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405566001568 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405566001569 substrate binding pocket [chemical binding]; other site 405566001570 membrane-bound complex binding site; other site 405566001571 hinge residues; other site 405566001572 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405566001573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566001574 dimer interface [polypeptide binding]; other site 405566001575 conserved gate region; other site 405566001576 putative PBP binding loops; other site 405566001577 ABC-ATPase subunit interface; other site 405566001578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566001579 dimer interface [polypeptide binding]; other site 405566001580 conserved gate region; other site 405566001581 putative PBP binding loops; other site 405566001582 ABC-ATPase subunit interface; other site 405566001583 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 405566001584 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 405566001585 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 405566001586 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 405566001587 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 405566001588 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 405566001589 nucleotide binding site/active site [active] 405566001590 HIT family signature motif; other site 405566001591 catalytic residue [active] 405566001592 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405566001593 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 405566001594 substrate binding site [chemical binding]; other site 405566001595 dimer interface [polypeptide binding]; other site 405566001596 ATP binding site [chemical binding]; other site 405566001597 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 405566001598 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405566001599 active site 405566001600 dimer interface [polypeptide binding]; other site 405566001601 K+ potassium transporter; Region: K_trans; pfam02705 405566001602 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 405566001603 active site 405566001604 tetramer interface [polypeptide binding]; other site 405566001605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405566001606 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405566001607 Probable transposase; Region: OrfB_IS605; pfam01385 405566001608 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566001609 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 405566001610 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 405566001611 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405566001612 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 405566001613 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405566001614 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566001615 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 405566001616 FeS assembly ATPase SufC; Region: sufC; TIGR01978 405566001617 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 405566001618 Walker A/P-loop; other site 405566001619 ATP binding site [chemical binding]; other site 405566001620 Q-loop/lid; other site 405566001621 ABC transporter signature motif; other site 405566001622 Walker B; other site 405566001623 D-loop; other site 405566001624 H-loop/switch region; other site 405566001625 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 405566001626 FeS assembly protein SufD; Region: sufD; TIGR01981 405566001627 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 405566001628 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 405566001629 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405566001630 catalytic residue [active] 405566001631 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 405566001632 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 405566001633 trimerization site [polypeptide binding]; other site 405566001634 active site 405566001635 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 405566001636 FeS assembly protein SufB; Region: sufB; TIGR01980 405566001637 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 405566001638 Enterocin A Immunity; Region: EntA_Immun; pfam08951 405566001639 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405566001640 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 405566001641 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405566001642 putative phosphoketolase; Provisional; Region: PRK05261 405566001643 XFP N-terminal domain; Region: XFP_N; pfam09364 405566001644 XFP C-terminal domain; Region: XFP_C; pfam09363 405566001645 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566001646 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566001647 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 405566001648 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 405566001649 active site 405566001650 nucleophile elbow; other site 405566001651 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 405566001652 HPr interaction site; other site 405566001653 glycerol kinase (GK) interaction site [polypeptide binding]; other site 405566001654 active site 405566001655 phosphorylation site [posttranslational modification] 405566001656 Domain of unknown function DUF21; Region: DUF21; pfam01595 405566001657 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405566001658 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405566001659 Transporter associated domain; Region: CorC_HlyC; smart01091 405566001660 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405566001661 active site 405566001662 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 405566001663 active site 405566001664 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 405566001665 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405566001666 DEAD/DEAH box helicase; Region: DEAD; pfam00270 405566001667 ATP binding site [chemical binding]; other site 405566001668 putative Mg++ binding site [ion binding]; other site 405566001669 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405566001670 nucleotide binding region [chemical binding]; other site 405566001671 ATP-binding site [chemical binding]; other site 405566001672 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 405566001673 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 405566001674 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 405566001675 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 405566001676 active site 405566001677 homodimer interface [polypeptide binding]; other site 405566001678 Predicted membrane protein [Function unknown]; Region: COG2246 405566001679 GtrA-like protein; Region: GtrA; pfam04138 405566001680 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 405566001681 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 405566001682 methionine aminopeptidase; Provisional; Region: PRK08671 405566001683 active site 405566001684 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 405566001685 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 405566001686 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 405566001687 active site 405566001688 tetramer interface; other site 405566001689 fragment of insertion sequence ISLjo5 405566001690 putative acyltransferase; Provisional; Region: PRK05790 405566001691 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405566001692 dimer interface [polypeptide binding]; other site 405566001693 active site 405566001694 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 405566001695 homodimer interface [polypeptide binding]; other site 405566001696 catalytic residues [active] 405566001697 NAD binding site [chemical binding]; other site 405566001698 substrate binding pocket [chemical binding]; other site 405566001699 flexible flap; other site 405566001700 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 405566001701 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 405566001702 dimer interface [polypeptide binding]; other site 405566001703 active site 405566001704 hydrolase; Region: PLN02811 405566001705 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566001706 MULE transposase domain; Region: MULE; pfam10551 405566001707 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405566001708 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 405566001709 acyl-activating enzyme (AAE) consensus motif; other site 405566001710 AMP binding site [chemical binding]; other site 405566001711 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 405566001712 Condensation domain; Region: Condensation; pfam00668 405566001713 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 405566001714 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 405566001715 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 405566001716 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 405566001717 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 405566001718 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 405566001719 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 405566001720 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566001721 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566001722 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 405566001723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405566001724 S-adenosylmethionine binding site [chemical binding]; other site 405566001725 recombination regulator RecX; Provisional; Region: recX; PRK14135 405566001726 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 405566001727 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405566001728 Transporter associated domain; Region: CorC_HlyC; pfam03471 405566001729 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 405566001730 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 405566001731 G1 box; other site 405566001732 putative GEF interaction site [polypeptide binding]; other site 405566001733 GTP/Mg2+ binding site [chemical binding]; other site 405566001734 Switch I region; other site 405566001735 G2 box; other site 405566001736 G3 box; other site 405566001737 Switch II region; other site 405566001738 G4 box; other site 405566001739 G5 box; other site 405566001740 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 405566001741 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 405566001742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405566001743 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 405566001744 Walker A motif; other site 405566001745 ATP binding site [chemical binding]; other site 405566001746 Walker B motif; other site 405566001747 arginine finger; other site 405566001748 UvrB/uvrC motif; Region: UVR; pfam02151 405566001749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405566001750 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 405566001751 Walker A motif; other site 405566001752 ATP binding site [chemical binding]; other site 405566001753 Walker B motif; other site 405566001754 arginine finger; other site 405566001755 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 405566001756 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 405566001757 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 405566001758 dimerization domain swap beta strand [polypeptide binding]; other site 405566001759 regulatory protein interface [polypeptide binding]; other site 405566001760 active site 405566001761 regulatory phosphorylation site [posttranslational modification]; other site 405566001762 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 405566001763 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 405566001764 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 405566001765 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 405566001766 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 405566001767 ArsC family; Region: ArsC; pfam03960 405566001768 putative catalytic residues [active] 405566001769 thiol/disulfide switch; other site 405566001770 adaptor protein; Provisional; Region: PRK02315 405566001771 Competence protein CoiA-like family; Region: CoiA; cl11541 405566001772 Thioredoxin; Region: Thioredoxin_5; pfam13743 405566001773 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 405566001774 putative active site [active] 405566001775 putative metal binding residues [ion binding]; other site 405566001776 signature motif; other site 405566001777 putative triphosphate binding site [ion binding]; other site 405566001778 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 405566001779 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 405566001780 synthetase active site [active] 405566001781 NTP binding site [chemical binding]; other site 405566001782 metal binding site [ion binding]; metal-binding site 405566001783 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 405566001784 ATP-NAD kinase; Region: NAD_kinase; pfam01513 405566001785 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 405566001786 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 405566001787 active site 405566001788 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405566001789 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 405566001790 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 405566001791 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 405566001792 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405566001793 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 405566001794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405566001795 motif II; other site 405566001796 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 405566001797 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405566001798 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405566001799 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 405566001800 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 405566001801 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 405566001802 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 405566001803 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405566001804 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 405566001805 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405566001806 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 405566001807 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 405566001808 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405566001809 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 405566001810 classical (c) SDRs; Region: SDR_c; cd05233 405566001811 NAD(P) binding site [chemical binding]; other site 405566001812 active site 405566001813 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 405566001814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405566001815 non-specific DNA binding site [nucleotide binding]; other site 405566001816 salt bridge; other site 405566001817 sequence-specific DNA binding site [nucleotide binding]; other site 405566001818 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 405566001819 recombinase A; Provisional; Region: recA; PRK09354 405566001820 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 405566001821 hexamer interface [polypeptide binding]; other site 405566001822 Walker A motif; other site 405566001823 ATP binding site [chemical binding]; other site 405566001824 Walker B motif; other site 405566001825 phosphodiesterase; Provisional; Region: PRK12704 405566001826 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405566001827 Zn2+ binding site [ion binding]; other site 405566001828 Mg2+ binding site [ion binding]; other site 405566001829 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 405566001830 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 405566001831 Mg++ binding site [ion binding]; other site 405566001832 putative catalytic motif [active] 405566001833 substrate binding site [chemical binding]; other site 405566001834 Uncharacterized conserved protein [Function unknown]; Region: COG1739 405566001835 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 405566001836 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 405566001837 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405566001838 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405566001839 ATP binding site [chemical binding]; other site 405566001840 putative Mg++ binding site [ion binding]; other site 405566001841 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405566001842 nucleotide binding region [chemical binding]; other site 405566001843 ATP-binding site [chemical binding]; other site 405566001844 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 405566001845 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405566001846 active site 405566001847 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 405566001848 30S subunit binding site; other site 405566001849 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 405566001850 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 405566001851 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405566001852 nucleotide binding region [chemical binding]; other site 405566001853 ATP-binding site [chemical binding]; other site 405566001854 peptide chain release factor 2; Provisional; Region: PRK05589 405566001855 This domain is found in peptide chain release factors; Region: PCRF; smart00937 405566001856 RF-1 domain; Region: RF-1; pfam00472 405566001857 HPr kinase/phosphorylase; Provisional; Region: PRK05428 405566001858 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 405566001859 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 405566001860 Hpr binding site; other site 405566001861 active site 405566001862 homohexamer subunit interaction site [polypeptide binding]; other site 405566001863 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 405566001864 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 405566001865 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 405566001866 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 405566001867 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405566001868 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405566001869 Probable transposase; Region: OrfB_IS605; pfam01385 405566001870 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566001871 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 405566001872 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 405566001873 N-terminal domain interface [polypeptide binding]; other site 405566001874 sulfate 1 binding site; other site 405566001875 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 405566001876 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 405566001877 active site 405566001878 substrate binding site [chemical binding]; other site 405566001879 metal binding site [ion binding]; metal-binding site 405566001880 excinuclease ABC subunit B; Provisional; Region: PRK05298 405566001881 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 405566001882 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405566001883 ATP-binding site [chemical binding]; other site 405566001884 ATP binding site [chemical binding]; other site 405566001885 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405566001886 nucleotide binding region [chemical binding]; other site 405566001887 ATP-binding site [chemical binding]; other site 405566001888 Ultra-violet resistance protein B; Region: UvrB; pfam12344 405566001889 UvrB/uvrC motif; Region: UVR; pfam02151 405566001890 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 405566001891 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 405566001892 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 405566001893 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 405566001894 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 405566001895 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 405566001896 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 405566001897 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 405566001898 putative substrate binding pocket [chemical binding]; other site 405566001899 dimer interface [polypeptide binding]; other site 405566001900 phosphate binding site [ion binding]; other site 405566001901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 405566001902 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 405566001903 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 405566001904 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 405566001905 oligomer interface [polypeptide binding]; other site 405566001906 active site residues [active] 405566001907 SH3-like domain; Region: SH3_8; pfam13457 405566001908 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 405566001909 Predicted transcriptional regulator [Transcription]; Region: COG3388 405566001910 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 405566001911 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 405566001912 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 405566001913 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 405566001914 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 405566001915 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 405566001916 Phosphoglycerate kinase; Region: PGK; pfam00162 405566001917 substrate binding site [chemical binding]; other site 405566001918 hinge regions; other site 405566001919 ADP binding site [chemical binding]; other site 405566001920 catalytic site [active] 405566001921 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 405566001922 triosephosphate isomerase; Provisional; Region: PRK14567 405566001923 substrate binding site [chemical binding]; other site 405566001924 dimer interface [polypeptide binding]; other site 405566001925 catalytic triad [active] 405566001926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405566001927 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405566001928 active site 405566001929 motif I; other site 405566001930 motif II; other site 405566001931 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405566001932 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 405566001933 ligand binding site [chemical binding]; other site 405566001934 active site 405566001935 UGI interface [polypeptide binding]; other site 405566001936 catalytic site [active] 405566001937 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 405566001938 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 405566001939 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 405566001940 active site 405566001941 catalytic site [active] 405566001942 substrate binding site [chemical binding]; other site 405566001943 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 405566001944 FAD binding domain; Region: FAD_binding_4; pfam01565 405566001945 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 405566001946 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 405566001947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405566001948 Walker A/P-loop; other site 405566001949 ATP binding site [chemical binding]; other site 405566001950 Q-loop/lid; other site 405566001951 ABC transporter signature motif; other site 405566001952 Walker B; other site 405566001953 D-loop; other site 405566001954 H-loop/switch region; other site 405566001955 TOBE domain; Region: TOBE_2; pfam08402 405566001956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566001957 dimer interface [polypeptide binding]; other site 405566001958 conserved gate region; other site 405566001959 putative PBP binding loops; other site 405566001960 ABC-ATPase subunit interface; other site 405566001961 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 405566001962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566001963 dimer interface [polypeptide binding]; other site 405566001964 conserved gate region; other site 405566001965 putative PBP binding loops; other site 405566001966 ABC-ATPase subunit interface; other site 405566001967 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 405566001968 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 405566001969 Uncharacterized conserved protein [Function unknown]; Region: COG1624 405566001970 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 405566001971 YbbR-like protein; Region: YbbR; pfam07949 405566001972 YbbR-like protein; Region: YbbR; pfam07949 405566001973 YbbR-like protein; Region: YbbR; pfam07949 405566001974 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 405566001975 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 405566001976 active site 405566001977 substrate binding site [chemical binding]; other site 405566001978 metal binding site [ion binding]; metal-binding site 405566001979 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 405566001980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405566001981 active site 405566001982 motif I; other site 405566001983 motif II; other site 405566001984 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 405566001985 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405566001986 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405566001987 active site 405566001988 motif I; other site 405566001989 motif II; other site 405566001990 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405566001991 clostripain; Region: clostrip; TIGR02806 405566001992 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 405566001993 Low molecular weight phosphatase family; Region: LMWPc; cd00115 405566001994 active site 405566001995 glycerate kinase; Region: TIGR00045 405566001996 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 405566001997 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 405566001998 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405566001999 active site turn [active] 405566002000 phosphorylation site [posttranslational modification] 405566002001 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405566002002 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 405566002003 HPr interaction site; other site 405566002004 glycerol kinase (GK) interaction site [polypeptide binding]; other site 405566002005 active site 405566002006 phosphorylation site [posttranslational modification] 405566002007 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405566002008 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 405566002009 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405566002010 Probable transposase; Region: OrfB_IS605; pfam01385 405566002011 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566002012 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405566002013 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 405566002014 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 405566002015 Predicted integral membrane protein [Function unknown]; Region: COG5652 405566002016 hypothetical protein; Validated; Region: PRK00110 405566002017 Type II/IV secretion system protein; Region: T2SE; pfam00437 405566002018 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 405566002019 Walker A motif; other site 405566002020 ATP binding site [chemical binding]; other site 405566002021 Walker B motif; other site 405566002022 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 405566002023 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 405566002024 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 405566002025 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 405566002026 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 405566002027 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 405566002028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405566002029 S-adenosylmethionine binding site [chemical binding]; other site 405566002030 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 405566002031 propionate/acetate kinase; Provisional; Region: PRK12379 405566002032 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 405566002033 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405566002034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405566002035 homodimer interface [polypeptide binding]; other site 405566002036 catalytic residue [active] 405566002037 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 405566002038 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 405566002039 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405566002040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405566002041 active site 405566002042 phosphorylation site [posttranslational modification] 405566002043 intermolecular recognition site; other site 405566002044 dimerization interface [polypeptide binding]; other site 405566002045 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405566002046 DNA binding site [nucleotide binding] 405566002047 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405566002048 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405566002049 dimerization interface [polypeptide binding]; other site 405566002050 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405566002051 dimer interface [polypeptide binding]; other site 405566002052 phosphorylation site [posttranslational modification] 405566002053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405566002054 ATP binding site [chemical binding]; other site 405566002055 Mg2+ binding site [ion binding]; other site 405566002056 G-X-G motif; other site 405566002057 Probable transposase; Region: OrfB_IS605; pfam01385 405566002058 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566002059 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405566002060 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 405566002061 VanZ like family; Region: VanZ; pfam04892 405566002062 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 405566002063 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 405566002064 active site 405566002065 dimer interface [polypeptide binding]; other site 405566002066 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 405566002067 dimer interface [polypeptide binding]; other site 405566002068 active site 405566002069 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 405566002070 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566002071 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 405566002072 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566002073 MULE transposase domain; Region: MULE; pfam10551 405566002074 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405566002075 Beta-lactamase; Region: Beta-lactamase; pfam00144 405566002076 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 405566002077 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405566002078 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 405566002079 thymidine kinase; Provisional; Region: PRK04296 405566002080 peptide chain release factor 1; Validated; Region: prfA; PRK00591 405566002081 This domain is found in peptide chain release factors; Region: PCRF; smart00937 405566002082 RF-1 domain; Region: RF-1; pfam00472 405566002083 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 405566002084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405566002085 S-adenosylmethionine binding site [chemical binding]; other site 405566002086 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 405566002087 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 405566002088 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 405566002089 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405566002090 active site 405566002091 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 405566002092 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 405566002093 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 405566002094 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 405566002095 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 405566002096 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 405566002097 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 405566002098 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 405566002099 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 405566002100 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 405566002101 beta subunit interaction interface [polypeptide binding]; other site 405566002102 Walker A motif; other site 405566002103 ATP binding site [chemical binding]; other site 405566002104 Walker B motif; other site 405566002105 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 405566002106 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 405566002107 core domain interface [polypeptide binding]; other site 405566002108 delta subunit interface [polypeptide binding]; other site 405566002109 epsilon subunit interface [polypeptide binding]; other site 405566002110 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 405566002111 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 405566002112 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 405566002113 alpha subunit interaction interface [polypeptide binding]; other site 405566002114 Walker A motif; other site 405566002115 ATP binding site [chemical binding]; other site 405566002116 Walker B motif; other site 405566002117 inhibitor binding site; inhibition site 405566002118 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 405566002119 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 405566002120 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 405566002121 gamma subunit interface [polypeptide binding]; other site 405566002122 epsilon subunit interface [polypeptide binding]; other site 405566002123 LBP interface [polypeptide binding]; other site 405566002124 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 405566002125 rod shape-determining protein MreB; Provisional; Region: PRK13930 405566002126 MreB and similar proteins; Region: MreB_like; cd10225 405566002127 nucleotide binding site [chemical binding]; other site 405566002128 Mg binding site [ion binding]; other site 405566002129 putative protofilament interaction site [polypeptide binding]; other site 405566002130 RodZ interaction site [polypeptide binding]; other site 405566002131 hypothetical protein; Provisional; Region: PRK14379 405566002132 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 405566002133 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 405566002134 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 405566002135 Ligand Binding Site [chemical binding]; other site 405566002136 recombination factor protein RarA; Reviewed; Region: PRK13342 405566002137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405566002138 Walker A motif; other site 405566002139 ATP binding site [chemical binding]; other site 405566002140 Walker B motif; other site 405566002141 arginine finger; other site 405566002142 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 405566002143 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 405566002144 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 405566002145 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 405566002146 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405566002147 RNA binding surface [nucleotide binding]; other site 405566002148 septation ring formation regulator EzrA; Provisional; Region: PRK04778 405566002149 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 405566002150 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 405566002151 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405566002152 catalytic residue [active] 405566002153 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 405566002154 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 405566002155 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 405566002156 Ligand Binding Site [chemical binding]; other site 405566002157 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405566002158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405566002159 non-specific DNA binding site [nucleotide binding]; other site 405566002160 salt bridge; other site 405566002161 sequence-specific DNA binding site [nucleotide binding]; other site 405566002162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405566002163 non-specific DNA binding site [nucleotide binding]; other site 405566002164 salt bridge; other site 405566002165 sequence-specific DNA binding site [nucleotide binding]; other site 405566002166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405566002167 non-specific DNA binding site [nucleotide binding]; other site 405566002168 salt bridge; other site 405566002169 sequence-specific DNA binding site [nucleotide binding]; other site 405566002170 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566002171 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 405566002172 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405566002173 RNA binding surface [nucleotide binding]; other site 405566002174 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 405566002175 active site 405566002176 uracil binding [chemical binding]; other site 405566002177 fragment of insertion sequence IS1201 405566002178 Predicted membrane protein [Function unknown]; Region: COG2246 405566002179 GtrA-like protein; Region: GtrA; pfam04138 405566002180 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 405566002181 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 405566002182 Ligand binding site; other site 405566002183 Putative Catalytic site; other site 405566002184 DXD motif; other site 405566002185 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405566002186 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405566002187 Probable transposase; Region: OrfB_IS605; pfam01385 405566002188 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566002189 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405566002190 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405566002191 Probable transposase; Region: OrfB_IS605; pfam01385 405566002192 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566002193 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 405566002194 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 405566002195 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 405566002196 active site 405566002197 HIGH motif; other site 405566002198 nucleotide binding site [chemical binding]; other site 405566002199 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 405566002200 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 405566002201 active site 405566002202 KMSKS motif; other site 405566002203 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 405566002204 tRNA binding surface [nucleotide binding]; other site 405566002205 anticodon binding site; other site 405566002206 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 405566002207 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 405566002208 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405566002209 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405566002210 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 405566002211 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405566002212 motif II; other site 405566002213 DNA repair protein radc; Region: radc; TIGR00608 405566002214 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 405566002215 MPN+ (JAMM) motif; other site 405566002216 Zinc-binding site [ion binding]; other site 405566002217 rod shape-determining protein MreB; Provisional; Region: PRK13927 405566002218 MreB and similar proteins; Region: MreB_like; cd10225 405566002219 nucleotide binding site [chemical binding]; other site 405566002220 Mg binding site [ion binding]; other site 405566002221 putative protofilament interaction site [polypeptide binding]; other site 405566002222 RodZ interaction site [polypeptide binding]; other site 405566002223 rod shape-determining protein MreC; Provisional; Region: PRK13922 405566002224 rod shape-determining protein MreC; Region: MreC; pfam04085 405566002225 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 405566002226 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566002227 MULE transposase domain; Region: MULE; pfam10551 405566002228 cell division protein MraZ; Reviewed; Region: PRK00326 405566002229 MraZ protein; Region: MraZ; pfam02381 405566002230 MraZ protein; Region: MraZ; pfam02381 405566002231 MraW methylase family; Region: Methyltransf_5; pfam01795 405566002232 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 405566002233 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 405566002234 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 405566002235 Mg++ binding site [ion binding]; other site 405566002236 putative catalytic motif [active] 405566002237 putative substrate binding site [chemical binding]; other site 405566002238 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 405566002239 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405566002240 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405566002241 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 405566002242 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 405566002243 active site 405566002244 homodimer interface [polypeptide binding]; other site 405566002245 Cell division protein FtsQ; Region: FtsQ; pfam03799 405566002246 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 405566002247 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405566002248 nucleotide binding site [chemical binding]; other site 405566002249 Cell division protein FtsA; Region: FtsA; cl17206 405566002250 Cell division protein FtsA; Region: FtsA; pfam14450 405566002251 cell division protein FtsZ; Validated; Region: PRK09330 405566002252 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 405566002253 nucleotide binding site [chemical binding]; other site 405566002254 SulA interaction site; other site 405566002255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 405566002256 YGGT family; Region: YGGT; pfam02325 405566002257 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 405566002258 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405566002259 RNA binding surface [nucleotide binding]; other site 405566002260 DivIVA protein; Region: DivIVA; pfam05103 405566002261 DivIVA domain; Region: DivI1A_domain; TIGR03544 405566002262 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 405566002263 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 405566002264 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 405566002265 active site 405566002266 HIGH motif; other site 405566002267 nucleotide binding site [chemical binding]; other site 405566002268 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 405566002269 active site 405566002270 KMSKS motif; other site 405566002271 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 405566002272 tRNA binding surface [nucleotide binding]; other site 405566002273 anticodon binding site; other site 405566002274 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 405566002275 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405566002276 DNA-binding site [nucleotide binding]; DNA binding site 405566002277 RNA-binding motif; other site 405566002278 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 405566002279 dimer interface [polypeptide binding]; other site 405566002280 ADP-ribose binding site [chemical binding]; other site 405566002281 active site 405566002282 nudix motif; other site 405566002283 metal binding site [ion binding]; metal-binding site 405566002284 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 405566002285 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 405566002286 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 405566002287 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 405566002288 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405566002289 catalytic residue [active] 405566002290 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 405566002291 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 405566002292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566002293 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566002294 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405566002295 catalytic core [active] 405566002296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405566002297 binding surface 405566002298 TPR motif; other site 405566002299 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 405566002300 AAA domain; Region: AAA_30; pfam13604 405566002301 Family description; Region: UvrD_C_2; pfam13538 405566002302 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 405566002303 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 405566002304 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405566002305 hypothetical protein; Provisional; Region: PRK13667 405566002306 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 405566002307 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 405566002308 active site 405566002309 catalytic residues [active] 405566002310 metal binding site [ion binding]; metal-binding site 405566002311 cell division protein FtsW; Region: ftsW; TIGR02614 405566002312 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 405566002313 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 405566002314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405566002315 S-adenosylmethionine binding site [chemical binding]; other site 405566002316 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 405566002317 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 405566002318 active site 405566002319 (T/H)XGH motif; other site 405566002320 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 405566002321 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405566002322 SLBB domain; Region: SLBB; pfam10531 405566002323 comEA protein; Region: comE; TIGR01259 405566002324 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 405566002325 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 405566002326 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 405566002327 Competence protein; Region: Competence; pfam03772 405566002328 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 405566002329 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405566002330 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 405566002331 DNA polymerase III, delta subunit; Region: holA; TIGR01128 405566002332 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 405566002333 16S/18S rRNA binding site [nucleotide binding]; other site 405566002334 S13e-L30e interaction site [polypeptide binding]; other site 405566002335 25S rRNA binding site [nucleotide binding]; other site 405566002336 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 405566002337 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405566002338 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405566002339 elongation factor Tu; Reviewed; Region: PRK00049 405566002340 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 405566002341 G1 box; other site 405566002342 GEF interaction site [polypeptide binding]; other site 405566002343 GTP/Mg2+ binding site [chemical binding]; other site 405566002344 Switch I region; other site 405566002345 G2 box; other site 405566002346 G3 box; other site 405566002347 Switch II region; other site 405566002348 G4 box; other site 405566002349 G5 box; other site 405566002350 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 405566002351 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 405566002352 Antibiotic Binding Site [chemical binding]; other site 405566002353 trigger factor; Provisional; Region: tig; PRK01490 405566002354 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 405566002355 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 405566002356 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 405566002357 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 405566002358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405566002359 Walker A motif; other site 405566002360 ATP binding site [chemical binding]; other site 405566002361 Walker B motif; other site 405566002362 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 405566002363 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 405566002364 G1 box; other site 405566002365 GTP/Mg2+ binding site [chemical binding]; other site 405566002366 Switch I region; other site 405566002367 G2 box; other site 405566002368 G3 box; other site 405566002369 Switch II region; other site 405566002370 G4 box; other site 405566002371 G5 box; other site 405566002372 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 405566002373 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566002374 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 405566002375 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 405566002376 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 405566002377 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 405566002378 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 405566002379 aspartate kinase; Reviewed; Region: PRK09034 405566002380 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 405566002381 putative catalytic residues [active] 405566002382 putative nucleotide binding site [chemical binding]; other site 405566002383 putative aspartate binding site [chemical binding]; other site 405566002384 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 405566002385 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 405566002386 diaminopimelate decarboxylase; Region: lysA; TIGR01048 405566002387 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 405566002388 active site 405566002389 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405566002390 substrate binding site [chemical binding]; other site 405566002391 catalytic residues [active] 405566002392 dimer interface [polypeptide binding]; other site 405566002393 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 405566002394 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 405566002395 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 405566002396 active site 405566002397 trimer interface [polypeptide binding]; other site 405566002398 substrate binding site [chemical binding]; other site 405566002399 CoA binding site [chemical binding]; other site 405566002400 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405566002401 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 405566002402 metal binding site [ion binding]; metal-binding site 405566002403 putative dimer interface [polypeptide binding]; other site 405566002404 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 405566002405 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 405566002406 dimer interface [polypeptide binding]; other site 405566002407 active site 405566002408 catalytic residue [active] 405566002409 dihydrodipicolinate reductase; Provisional; Region: PRK00048 405566002410 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 405566002411 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 405566002412 aromatic amino acid aminotransferase; Validated; Region: PRK07309 405566002413 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405566002414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405566002415 homodimer interface [polypeptide binding]; other site 405566002416 catalytic residue [active] 405566002417 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 405566002418 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 405566002419 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405566002420 Beta-lactamase; Region: Beta-lactamase; pfam00144 405566002421 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 405566002422 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 405566002423 nudix motif; other site 405566002424 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 405566002425 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 405566002426 active site 405566002427 dimerization interface [polypeptide binding]; other site 405566002428 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405566002429 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405566002430 DNA-binding site [nucleotide binding]; DNA binding site 405566002431 UTRA domain; Region: UTRA; pfam07702 405566002432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566002433 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566002434 Isochorismatase family; Region: Isochorismatase; pfam00857 405566002435 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 405566002436 catalytic triad [active] 405566002437 conserved cis-peptide bond; other site 405566002438 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 405566002439 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 405566002440 active site 405566002441 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 405566002442 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 405566002443 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566002444 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 405566002445 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566002446 MULE transposase domain; Region: MULE; pfam10551 405566002447 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 405566002448 nudix motif; other site 405566002449 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 405566002450 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405566002451 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405566002452 DNA-binding site [nucleotide binding]; DNA binding site 405566002453 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 405566002454 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 405566002455 Probable transposase; Region: OrfB_IS605; pfam01385 405566002456 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566002457 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405566002458 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 405566002459 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 405566002460 beta-galactosidase; Region: BGL; TIGR03356 405566002461 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 405566002462 FMN binding site [chemical binding]; other site 405566002463 dimer interface [polypeptide binding]; other site 405566002464 enolase; Provisional; Region: eno; PRK00077 405566002465 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 405566002466 dimer interface [polypeptide binding]; other site 405566002467 metal binding site [ion binding]; metal-binding site 405566002468 substrate binding pocket [chemical binding]; other site 405566002469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 405566002470 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566002471 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 405566002472 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 405566002473 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405566002474 active site 405566002475 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566002476 MULE transposase domain; Region: MULE; pfam10551 405566002477 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 405566002478 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 405566002479 thymidylate synthase; Region: thym_sym; TIGR03284 405566002480 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 405566002481 dimerization interface [polypeptide binding]; other site 405566002482 active site 405566002483 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 405566002484 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 405566002485 folate binding site [chemical binding]; other site 405566002486 NADP+ binding site [chemical binding]; other site 405566002487 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 405566002488 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405566002489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405566002490 motif I; other site 405566002491 motif II; other site 405566002492 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 405566002493 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 405566002494 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 405566002495 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 405566002496 Walker A/P-loop; other site 405566002497 ATP binding site [chemical binding]; other site 405566002498 Q-loop/lid; other site 405566002499 ABC transporter signature motif; other site 405566002500 Walker B; other site 405566002501 D-loop; other site 405566002502 H-loop/switch region; other site 405566002503 NIL domain; Region: NIL; pfam09383 405566002504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566002505 dimer interface [polypeptide binding]; other site 405566002506 conserved gate region; other site 405566002507 ABC-ATPase subunit interface; other site 405566002508 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566002509 MULE transposase domain; Region: MULE; pfam10551 405566002510 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566002511 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 405566002512 fumarate hydratase; Reviewed; Region: fumC; PRK00485 405566002513 Class II fumarases; Region: Fumarase_classII; cd01362 405566002514 active site 405566002515 tetramer interface [polypeptide binding]; other site 405566002516 L-aspartate oxidase; Provisional; Region: PRK06175 405566002517 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 405566002518 Predicted oxidoreductase [General function prediction only]; Region: COG3573 405566002519 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 405566002520 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 405566002521 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 405566002522 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405566002523 NAD binding site [chemical binding]; other site 405566002524 dimer interface [polypeptide binding]; other site 405566002525 substrate binding site [chemical binding]; other site 405566002526 MucBP domain; Region: MucBP; pfam06458 405566002527 Transposase; Region: DEDD_Tnp_IS110; pfam01548 405566002528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 405566002529 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 405566002530 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566002531 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566002532 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 405566002533 trimer interface [polypeptide binding]; other site 405566002534 active site 405566002535 G bulge; other site 405566002536 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 405566002537 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 405566002538 transmembrane helices; other site 405566002539 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405566002540 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 405566002541 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 405566002542 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 405566002543 active site 405566002544 nucleotide binding site [chemical binding]; other site 405566002545 HIGH motif; other site 405566002546 KMSKS motif; other site 405566002547 citrate lyase subunit gamma; Provisional; Region: PRK13253 405566002548 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 405566002549 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 405566002550 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 405566002551 Protein of unknown function (DUF441); Region: DUF441; pfam04284 405566002552 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 405566002553 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405566002554 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405566002555 Walker A/P-loop; other site 405566002556 ATP binding site [chemical binding]; other site 405566002557 Q-loop/lid; other site 405566002558 ABC transporter signature motif; other site 405566002559 Walker B; other site 405566002560 D-loop; other site 405566002561 H-loop/switch region; other site 405566002562 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 405566002563 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405566002564 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405566002565 Walker A/P-loop; other site 405566002566 ATP binding site [chemical binding]; other site 405566002567 Q-loop/lid; other site 405566002568 ABC transporter signature motif; other site 405566002569 Walker B; other site 405566002570 D-loop; other site 405566002571 H-loop/switch region; other site 405566002572 hypothetical protein; Provisional; Region: PRK13661 405566002573 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 405566002574 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 405566002575 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 405566002576 Uncharacterized conserved protein [Function unknown]; Region: COG2966 405566002577 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 405566002578 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 405566002579 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 405566002580 substrate binding site [chemical binding]; other site 405566002581 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 405566002582 putative deacylase active site [active] 405566002583 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 405566002584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405566002585 S-adenosylmethionine binding site [chemical binding]; other site 405566002586 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 405566002587 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405566002588 Zn2+ binding site [ion binding]; other site 405566002589 Mg2+ binding site [ion binding]; other site 405566002590 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 405566002591 synthetase active site [active] 405566002592 NTP binding site [chemical binding]; other site 405566002593 metal binding site [ion binding]; metal-binding site 405566002594 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 405566002595 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 405566002596 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 405566002597 putative active site [active] 405566002598 dimerization interface [polypeptide binding]; other site 405566002599 putative tRNAtyr binding site [nucleotide binding]; other site 405566002600 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 405566002601 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 405566002602 dimer interface [polypeptide binding]; other site 405566002603 motif 1; other site 405566002604 active site 405566002605 motif 2; other site 405566002606 motif 3; other site 405566002607 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 405566002608 anticodon binding site; other site 405566002609 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 405566002610 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 405566002611 dimer interface [polypeptide binding]; other site 405566002612 anticodon binding site; other site 405566002613 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 405566002614 homodimer interface [polypeptide binding]; other site 405566002615 motif 1; other site 405566002616 active site 405566002617 motif 2; other site 405566002618 GAD domain; Region: GAD; pfam02938 405566002619 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 405566002620 active site 405566002621 motif 3; other site 405566002622 aromatic amino acid aminotransferase; Validated; Region: PRK07309 405566002623 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405566002624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405566002625 homodimer interface [polypeptide binding]; other site 405566002626 catalytic residue [active] 405566002627 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 405566002628 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 405566002629 Flavoprotein; Region: Flavoprotein; pfam02441 405566002630 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 405566002631 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405566002632 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405566002633 active site 405566002634 catalytic tetrad [active] 405566002635 amino acid transporter; Region: 2A0306; TIGR00909 405566002636 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 405566002637 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405566002638 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405566002639 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566002640 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 405566002641 Mrr N-terminal domain; Region: Mrr_N; pfam14338 405566002642 Restriction endonuclease; Region: Mrr_cat; pfam04471 405566002643 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 405566002644 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566002645 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 405566002646 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566002647 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 405566002648 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 405566002649 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 405566002650 GIY-YIG motif/motif A; other site 405566002651 active site 405566002652 catalytic site [active] 405566002653 putative DNA binding site [nucleotide binding]; other site 405566002654 metal binding site [ion binding]; metal-binding site 405566002655 UvrB/uvrC motif; Region: UVR; pfam02151 405566002656 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 405566002657 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 405566002658 DNA binding site [nucleotide binding] 405566002659 GTPase CgtA; Reviewed; Region: obgE; PRK12297 405566002660 GTP1/OBG; Region: GTP1_OBG; pfam01018 405566002661 Obg GTPase; Region: Obg; cd01898 405566002662 G1 box; other site 405566002663 GTP/Mg2+ binding site [chemical binding]; other site 405566002664 Switch I region; other site 405566002665 G2 box; other site 405566002666 G3 box; other site 405566002667 Switch II region; other site 405566002668 G4 box; other site 405566002669 G5 box; other site 405566002670 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 405566002671 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 405566002672 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 405566002673 catalytic triad [active] 405566002674 catalytic triad [active] 405566002675 oxyanion hole [active] 405566002676 ribonuclease Z; Region: RNase_Z; TIGR02651 405566002677 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 405566002678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405566002679 NAD(P) binding site [chemical binding]; other site 405566002680 active site 405566002681 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 405566002682 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405566002683 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 405566002684 active site 405566002685 metal binding site [ion binding]; metal-binding site 405566002686 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405566002687 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 405566002688 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 405566002689 active site 405566002690 PHP Thumb interface [polypeptide binding]; other site 405566002691 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 405566002692 generic binding surface I; other site 405566002693 generic binding surface II; other site 405566002694 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 405566002695 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 405566002696 active site 405566002697 ADP/pyrophosphate binding site [chemical binding]; other site 405566002698 dimerization interface [polypeptide binding]; other site 405566002699 allosteric effector site; other site 405566002700 fructose-1,6-bisphosphate binding site; other site 405566002701 pyruvate kinase; Provisional; Region: PRK06354 405566002702 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 405566002703 domain interfaces; other site 405566002704 active site 405566002705 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 405566002706 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 405566002707 S1 domain; Region: S1_2; pfam13509 405566002708 MarR family; Region: MarR_2; pfam12802 405566002709 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 405566002710 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 405566002711 active site 405566002712 Int/Topo IB signature motif; other site 405566002713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405566002714 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 405566002715 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 405566002716 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 405566002717 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405566002718 RNA binding surface [nucleotide binding]; other site 405566002719 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 405566002720 active site 405566002721 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 405566002722 Predicted membrane protein [Function unknown]; Region: COG3601 405566002723 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 405566002724 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566002725 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 405566002726 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405566002727 cytidylate kinase; Provisional; Region: cmk; PRK00023 405566002728 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 405566002729 CMP-binding site; other site 405566002730 The sites determining sugar specificity; other site 405566002731 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 405566002732 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 405566002733 RNA binding site [nucleotide binding]; other site 405566002734 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 405566002735 RNA binding site [nucleotide binding]; other site 405566002736 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 405566002737 RNA binding site [nucleotide binding]; other site 405566002738 GTP-binding protein Der; Reviewed; Region: PRK00093 405566002739 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 405566002740 G1 box; other site 405566002741 GTP/Mg2+ binding site [chemical binding]; other site 405566002742 Switch I region; other site 405566002743 G2 box; other site 405566002744 Switch II region; other site 405566002745 G3 box; other site 405566002746 G4 box; other site 405566002747 G5 box; other site 405566002748 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 405566002749 G1 box; other site 405566002750 GTP/Mg2+ binding site [chemical binding]; other site 405566002751 Switch I region; other site 405566002752 G2 box; other site 405566002753 G3 box; other site 405566002754 Switch II region; other site 405566002755 G4 box; other site 405566002756 G5 box; other site 405566002757 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 405566002758 IHF dimer interface [polypeptide binding]; other site 405566002759 IHF - DNA interface [nucleotide binding]; other site 405566002760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 405566002761 binding surface 405566002762 TPR motif; other site 405566002763 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 405566002764 binding surface 405566002765 TPR motif; other site 405566002766 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405566002767 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405566002768 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405566002769 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405566002770 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 405566002771 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 405566002772 active site 405566002773 NTP binding site [chemical binding]; other site 405566002774 metal binding triad [ion binding]; metal-binding site 405566002775 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 405566002776 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 405566002777 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 405566002778 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 405566002779 EDD domain protein, DegV family; Region: DegV; TIGR00762 405566002780 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405566002781 hypothetical protein; Provisional; Region: PRK13672 405566002782 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405566002783 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 405566002784 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 405566002785 GTP/Mg2+ binding site [chemical binding]; other site 405566002786 G4 box; other site 405566002787 G5 box; other site 405566002788 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 405566002789 G1 box; other site 405566002790 G1 box; other site 405566002791 GTP/Mg2+ binding site [chemical binding]; other site 405566002792 Switch I region; other site 405566002793 G2 box; other site 405566002794 G2 box; other site 405566002795 Switch I region; other site 405566002796 G3 box; other site 405566002797 G3 box; other site 405566002798 Switch II region; other site 405566002799 Switch II region; other site 405566002800 G4 box; other site 405566002801 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 405566002802 RNA/DNA hybrid binding site [nucleotide binding]; other site 405566002803 active site 405566002804 DNA protecting protein DprA; Region: dprA; TIGR00732 405566002805 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 405566002806 DNA topoisomerase I; Validated; Region: PRK05582 405566002807 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 405566002808 active site 405566002809 interdomain interaction site; other site 405566002810 putative metal-binding site [ion binding]; other site 405566002811 nucleotide binding site [chemical binding]; other site 405566002812 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 405566002813 domain I; other site 405566002814 DNA binding groove [nucleotide binding] 405566002815 phosphate binding site [ion binding]; other site 405566002816 domain II; other site 405566002817 domain III; other site 405566002818 nucleotide binding site [chemical binding]; other site 405566002819 catalytic site [active] 405566002820 domain IV; other site 405566002821 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405566002822 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405566002823 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 405566002824 Glucose inhibited division protein A; Region: GIDA; pfam01134 405566002825 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405566002826 active site 405566002827 DNA binding site [nucleotide binding] 405566002828 Int/Topo IB signature motif; other site 405566002829 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 405566002830 active site 405566002831 HslU subunit interaction site [polypeptide binding]; other site 405566002832 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 405566002833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405566002834 Walker A motif; other site 405566002835 ATP binding site [chemical binding]; other site 405566002836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 405566002837 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 405566002838 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 405566002839 active site 405566002840 catalytic residues [active] 405566002841 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 405566002842 Integrase core domain; Region: rve; pfam00665 405566002843 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405566002844 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 405566002845 camphor resistance protein CrcB; Provisional; Region: PRK14220 405566002846 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566002847 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 405566002848 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405566002849 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 405566002850 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 405566002851 Walker A/P-loop; other site 405566002852 ATP binding site [chemical binding]; other site 405566002853 Q-loop/lid; other site 405566002854 ABC transporter signature motif; other site 405566002855 Walker B; other site 405566002856 D-loop; other site 405566002857 H-loop/switch region; other site 405566002858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566002859 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566002860 Transposase; Region: DEDD_Tnp_IS110; pfam01548 405566002861 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 405566002862 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405566002863 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405566002864 Presynaptic Site I dimer interface [polypeptide binding]; other site 405566002865 catalytic residues [active] 405566002866 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405566002867 Synaptic Flat tetramer interface [polypeptide binding]; other site 405566002868 Synaptic Site I dimer interface [polypeptide binding]; other site 405566002869 DNA binding site [nucleotide binding] 405566002870 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 405566002871 DNA-binding interface [nucleotide binding]; DNA binding site 405566002872 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566002873 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 405566002874 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 405566002875 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 405566002876 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405566002877 catalytic residue [active] 405566002878 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 405566002879 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 405566002880 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 405566002881 Aluminium resistance protein; Region: Alum_res; pfam06838 405566002882 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 405566002883 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405566002884 ATP binding site [chemical binding]; other site 405566002885 putative Mg++ binding site [ion binding]; other site 405566002886 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405566002887 nucleotide binding region [chemical binding]; other site 405566002888 ATP-binding site [chemical binding]; other site 405566002889 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 405566002890 HRDC domain; Region: HRDC; pfam00570 405566002891 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566002892 MULE transposase domain; Region: MULE; pfam10551 405566002893 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 405566002894 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 405566002895 active site 405566002896 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405566002897 maltose O-acetyltransferase; Provisional; Region: PRK10092 405566002898 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 405566002899 active site 405566002900 substrate binding site [chemical binding]; other site 405566002901 trimer interface [polypeptide binding]; other site 405566002902 CoA binding site [chemical binding]; other site 405566002903 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405566002904 Beta-lactamase; Region: Beta-lactamase; pfam00144 405566002905 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 405566002906 pyridoxal binding site [chemical binding]; other site 405566002907 dimer interface [polypeptide binding]; other site 405566002908 ATP binding site [chemical binding]; other site 405566002909 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 405566002910 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 405566002911 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405566002912 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 405566002913 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 405566002914 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 405566002915 peptidase T; Region: peptidase-T; TIGR01882 405566002916 metal binding site [ion binding]; metal-binding site 405566002917 dimer interface [polypeptide binding]; other site 405566002918 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405566002919 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405566002920 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 405566002921 Walker A/P-loop; other site 405566002922 ATP binding site [chemical binding]; other site 405566002923 Q-loop/lid; other site 405566002924 ABC transporter signature motif; other site 405566002925 Walker B; other site 405566002926 D-loop; other site 405566002927 H-loop/switch region; other site 405566002928 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405566002929 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405566002930 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 405566002931 Walker A/P-loop; other site 405566002932 ATP binding site [chemical binding]; other site 405566002933 Q-loop/lid; other site 405566002934 ABC transporter signature motif; other site 405566002935 Walker B; other site 405566002936 D-loop; other site 405566002937 H-loop/switch region; other site 405566002938 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 405566002939 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 405566002940 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 405566002941 Fic/DOC family; Region: Fic; cl00960 405566002942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405566002943 H+ Antiporter protein; Region: 2A0121; TIGR00900 405566002944 putative substrate translocation pore; other site 405566002945 Probable transposase; Region: OrfB_IS605; pfam01385 405566002946 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566002947 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405566002948 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 405566002949 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405566002950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405566002951 Coenzyme A binding pocket [chemical binding]; other site 405566002952 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 405566002953 active site 405566002954 catalytic motif [active] 405566002955 Zn binding site [ion binding]; other site 405566002956 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 405566002957 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 405566002958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 405566002959 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 405566002960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405566002961 Walker A/P-loop; other site 405566002962 ATP binding site [chemical binding]; other site 405566002963 Q-loop/lid; other site 405566002964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405566002965 ABC transporter signature motif; other site 405566002966 Walker B; other site 405566002967 D-loop; other site 405566002968 H-loop/switch region; other site 405566002969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405566002970 AAA domain; Region: AAA_21; pfam13304 405566002971 Walker A/P-loop; other site 405566002972 ATP binding site [chemical binding]; other site 405566002973 Q-loop/lid; other site 405566002974 ABC transporter signature motif; other site 405566002975 Walker B; other site 405566002976 D-loop; other site 405566002977 H-loop/switch region; other site 405566002978 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 405566002979 active site 405566002980 dimerization interface [polypeptide binding]; other site 405566002981 LytTr DNA-binding domain; Region: LytTR; smart00850 405566002982 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 405566002983 MutS domain III; Region: MutS_III; pfam05192 405566002984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405566002985 Walker A/P-loop; other site 405566002986 ATP binding site [chemical binding]; other site 405566002987 Q-loop/lid; other site 405566002988 ABC transporter signature motif; other site 405566002989 Walker B; other site 405566002990 D-loop; other site 405566002991 H-loop/switch region; other site 405566002992 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405566002993 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405566002994 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405566002995 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405566002996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405566002997 Walker A/P-loop; other site 405566002998 ATP binding site [chemical binding]; other site 405566002999 Q-loop/lid; other site 405566003000 ABC transporter signature motif; other site 405566003001 Walker B; other site 405566003002 D-loop; other site 405566003003 H-loop/switch region; other site 405566003004 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 405566003005 Walker A/P-loop; other site 405566003006 ATP binding site [chemical binding]; other site 405566003007 ABC transporter; Region: ABC_tran; pfam00005 405566003008 Q-loop/lid; other site 405566003009 ABC transporter signature motif; other site 405566003010 Walker B; other site 405566003011 D-loop; other site 405566003012 H-loop/switch region; other site 405566003013 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 405566003014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405566003015 Walker A/P-loop; other site 405566003016 ATP binding site [chemical binding]; other site 405566003017 Q-loop/lid; other site 405566003018 ABC transporter signature motif; other site 405566003019 Walker B; other site 405566003020 D-loop; other site 405566003021 H-loop/switch region; other site 405566003022 SH3-like domain; Region: SH3_8; pfam13457 405566003023 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 405566003024 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405566003025 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405566003026 Probable transposase; Region: OrfB_IS605; pfam01385 405566003027 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566003028 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 405566003029 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 405566003030 Mrr N-terminal domain; Region: Mrr_N; pfam14338 405566003031 Restriction endonuclease; Region: Mrr_cat; pfam04471 405566003032 HsdM N-terminal domain; Region: HsdM_N; pfam12161 405566003033 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 405566003034 Methyltransferase domain; Region: Methyltransf_26; pfam13659 405566003035 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 405566003036 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 405566003037 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 405566003038 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 405566003039 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 405566003040 Int/Topo IB signature motif; other site 405566003041 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 405566003042 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 405566003043 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 405566003044 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 405566003045 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405566003046 ATP binding site [chemical binding]; other site 405566003047 putative Mg++ binding site [ion binding]; other site 405566003048 fragment of insertion sequence ISL2 405566003049 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405566003050 M20 Peptidase Aminoacylase 1-like protein 2, amidohydrolase family; Region: M20_Acy1L2_like_2; cd09849 405566003051 metal binding site [ion binding]; metal-binding site 405566003052 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 405566003053 fragment of transposon Tn3692 405566003054 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 405566003055 HTH-like domain; Region: HTH_21; pfam13276 405566003056 Integrase core domain; Region: rve; pfam00665 405566003057 Integrase core domain; Region: rve_2; pfam13333 405566003058 Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565 405566003059 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 405566003060 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 405566003061 active site 405566003062 Zn binding site [ion binding]; other site 405566003063 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 405566003064 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 405566003065 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405566003066 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 405566003067 metal binding site [ion binding]; metal-binding site 405566003068 dimer interface [polypeptide binding]; other site 405566003069 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 405566003070 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 405566003071 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 405566003072 AAA ATPase domain; Region: AAA_16; pfam13191 405566003073 Uncharacterized conserved protein [Function unknown]; Region: COG3410 405566003074 Probable transposase; Region: OrfB_IS605; pfam01385 405566003075 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566003076 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405566003077 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 405566003078 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405566003079 active site 405566003080 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 405566003081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405566003082 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405566003083 Probable transposase; Region: OrfB_IS605; pfam01385 405566003084 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566003085 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 405566003086 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 405566003087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405566003088 HTH-like domain; Region: HTH_21; pfam13276 405566003089 Integrase core domain; Region: rve; pfam00665 405566003090 Integrase core domain; Region: rve_2; pfam13333 405566003091 dipeptidase PepV; Reviewed; Region: PRK07318 405566003092 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 405566003093 active site 405566003094 metal binding site [ion binding]; metal-binding site 405566003095 Beta-lactamase; Region: Beta-lactamase; pfam00144 405566003096 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405566003097 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 405566003098 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 405566003099 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405566003100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405566003101 Coenzyme A binding pocket [chemical binding]; other site 405566003102 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 405566003103 LytTr DNA-binding domain; Region: LytTR; smart00850 405566003104 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 405566003105 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566003106 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 405566003107 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405566003108 endonuclease III; Region: ENDO3c; smart00478 405566003109 minor groove reading motif; other site 405566003110 helix-hairpin-helix signature motif; other site 405566003111 substrate binding pocket [chemical binding]; other site 405566003112 active site 405566003113 Dihydroneopterin aldolase; Region: FolB; pfam02152 405566003114 active site 405566003115 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 405566003116 catalytic center binding site [active] 405566003117 ATP binding site [chemical binding]; other site 405566003118 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 405566003119 GTP cyclohydrolase I; Provisional; Region: PLN03044 405566003120 active site 405566003121 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 405566003122 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405566003123 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405566003124 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 405566003125 dihydropteroate synthase; Region: DHPS; TIGR01496 405566003126 substrate binding pocket [chemical binding]; other site 405566003127 dimer interface [polypeptide binding]; other site 405566003128 inhibitor binding site; inhibition site 405566003129 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 405566003130 nudix motif; other site 405566003131 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 405566003132 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405566003133 DNA binding residues [nucleotide binding] 405566003134 putative dimer interface [polypeptide binding]; other site 405566003135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566003136 dimer interface [polypeptide binding]; other site 405566003137 conserved gate region; other site 405566003138 putative PBP binding loops; other site 405566003139 ABC-ATPase subunit interface; other site 405566003140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566003141 dimer interface [polypeptide binding]; other site 405566003142 conserved gate region; other site 405566003143 putative PBP binding loops; other site 405566003144 ABC-ATPase subunit interface; other site 405566003145 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405566003146 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405566003147 Walker A/P-loop; other site 405566003148 ATP binding site [chemical binding]; other site 405566003149 Q-loop/lid; other site 405566003150 ABC transporter signature motif; other site 405566003151 Walker B; other site 405566003152 D-loop; other site 405566003153 H-loop/switch region; other site 405566003154 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 405566003155 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405566003156 substrate binding pocket [chemical binding]; other site 405566003157 membrane-bound complex binding site; other site 405566003158 hinge residues; other site 405566003159 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 405566003160 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405566003161 active site 405566003162 DNA binding site [nucleotide binding] 405566003163 Int/Topo IB signature motif; other site 405566003164 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 405566003165 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405566003166 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405566003167 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405566003168 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 405566003169 dimer interface [polypeptide binding]; other site 405566003170 FMN binding site [chemical binding]; other site 405566003171 NADPH bind site [chemical binding]; other site 405566003172 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 405566003173 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 405566003174 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 405566003175 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 405566003176 dimerization interface [polypeptide binding]; other site 405566003177 DPS ferroxidase diiron center [ion binding]; other site 405566003178 ion pore; other site 405566003179 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 405566003180 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 405566003181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405566003182 Mg2+ binding site [ion binding]; other site 405566003183 G-X-G motif; other site 405566003184 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 405566003185 anchoring element; other site 405566003186 dimer interface [polypeptide binding]; other site 405566003187 ATP binding site [chemical binding]; other site 405566003188 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 405566003189 active site 405566003190 putative metal-binding site [ion binding]; other site 405566003191 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 405566003192 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 405566003193 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 405566003194 CAP-like domain; other site 405566003195 active site 405566003196 primary dimer interface [polypeptide binding]; other site 405566003197 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405566003198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405566003199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405566003200 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405566003201 dimerization interface [polypeptide binding]; other site 405566003202 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 405566003203 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 405566003204 DHHA2 domain; Region: DHHA2; pfam02833 405566003205 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 405566003206 active site 405566003207 GDA1/CD39 (nucleoside phosphatase) family; Region: GDA1_CD39; cl17763 405566003208 fragment of insertion sequence ISLhe1 405566003209 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 405566003210 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566003211 MULE transposase domain; Region: MULE; pfam10551 405566003212 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566003213 MULE transposase domain; Region: MULE; pfam10551 405566003214 topology modulation protein; Reviewed; Region: PRK08118 405566003215 AAA domain; Region: AAA_17; pfam13207 405566003216 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 405566003217 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405566003218 active site 405566003219 DNA binding site [nucleotide binding] 405566003220 Int/Topo IB signature motif; other site 405566003221 EDD domain protein, DegV family; Region: DegV; TIGR00762 405566003222 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405566003223 Transcriptional regulators [Transcription]; Region: MarR; COG1846 405566003224 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 405566003225 Domain of unknown function (DUF814); Region: DUF814; pfam05670 405566003226 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 405566003227 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405566003228 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405566003229 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 405566003230 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405566003231 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 405566003232 IMP binding site; other site 405566003233 dimer interface [polypeptide binding]; other site 405566003234 interdomain contacts; other site 405566003235 partial ornithine binding site; other site 405566003236 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 405566003237 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 405566003238 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 405566003239 conserved cys residue [active] 405566003240 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 405566003241 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405566003242 RNA binding surface [nucleotide binding]; other site 405566003243 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 405566003244 active site 405566003245 lipoprotein signal peptidase; Provisional; Region: PRK14797 405566003246 lipoprotein signal peptidase; Provisional; Region: PRK14787 405566003247 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 405566003248 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 405566003249 Potassium binding sites [ion binding]; other site 405566003250 Cesium cation binding sites [ion binding]; other site 405566003251 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 405566003252 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 405566003253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 405566003254 DivIVA protein; Region: DivIVA; pfam05103 405566003255 DivIVA domain; Region: DivI1A_domain; TIGR03544 405566003256 hypothetical protein; Provisional; Region: PRK13660 405566003257 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 405566003258 Transglycosylase; Region: Transgly; pfam00912 405566003259 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405566003260 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 405566003261 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405566003262 endonuclease III; Region: ENDO3c; smart00478 405566003263 minor groove reading motif; other site 405566003264 helix-hairpin-helix signature motif; other site 405566003265 substrate binding pocket [chemical binding]; other site 405566003266 active site 405566003267 Helix-turn-helix domain; Region: HTH_36; pfam13730 405566003268 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405566003269 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 405566003270 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 405566003271 putative dimer interface [polypeptide binding]; other site 405566003272 putative anticodon binding site; other site 405566003273 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 405566003274 homodimer interface [polypeptide binding]; other site 405566003275 motif 1; other site 405566003276 motif 2; other site 405566003277 active site 405566003278 motif 3; other site 405566003279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 405566003280 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 405566003281 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 405566003282 active site 405566003283 catalytic site [active] 405566003284 substrate binding site [chemical binding]; other site 405566003285 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 405566003286 ATP binding site [chemical binding]; other site 405566003287 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 405566003288 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 405566003289 Part of AAA domain; Region: AAA_19; pfam13245 405566003290 Family description; Region: UvrD_C_2; pfam13538 405566003291 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 405566003292 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 405566003293 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 405566003294 mevalonate kinase; Region: mevalon_kin; TIGR00549 405566003295 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 405566003296 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 405566003297 diphosphomevalonate decarboxylase; Region: PLN02407 405566003298 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 405566003299 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 405566003300 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 405566003301 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 405566003302 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 405566003303 homotetramer interface [polypeptide binding]; other site 405566003304 FMN binding site [chemical binding]; other site 405566003305 homodimer contacts [polypeptide binding]; other site 405566003306 putative active site [active] 405566003307 putative substrate binding site [chemical binding]; other site 405566003308 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 405566003309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405566003310 S-adenosylmethionine binding site [chemical binding]; other site 405566003311 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 405566003312 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405566003313 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405566003314 Catalytic site [active] 405566003315 recombination factor protein RarA; Reviewed; Region: PRK13342 405566003316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405566003317 Walker A motif; other site 405566003318 ATP binding site [chemical binding]; other site 405566003319 Walker B motif; other site 405566003320 arginine finger; other site 405566003321 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 405566003322 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 405566003323 Helix-turn-helix domain; Region: HTH_38; pfam13936 405566003324 Integrase core domain; Region: rve; pfam00665 405566003325 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 405566003326 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405566003327 Walker A/P-loop; other site 405566003328 ATP binding site [chemical binding]; other site 405566003329 Q-loop/lid; other site 405566003330 ABC transporter signature motif; other site 405566003331 Walker B; other site 405566003332 D-loop; other site 405566003333 H-loop/switch region; other site 405566003334 Predicted transcriptional regulators [Transcription]; Region: COG1725 405566003335 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405566003336 DNA-binding site [nucleotide binding]; DNA binding site 405566003337 peptidase T; Region: peptidase-T; TIGR01882 405566003338 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 405566003339 metal binding site [ion binding]; metal-binding site 405566003340 dimer interface [polypeptide binding]; other site 405566003341 Uncharacterized conserved protein [Function unknown]; Region: COG0327 405566003342 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 405566003343 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 405566003344 Family of unknown function (DUF633); Region: DUF633; pfam04816 405566003345 Peptidase family M23; Region: Peptidase_M23; pfam01551 405566003346 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 405566003347 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 405566003348 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405566003349 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 405566003350 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405566003351 DNA binding residues [nucleotide binding] 405566003352 DNA primase; Validated; Region: dnaG; PRK05667 405566003353 CHC2 zinc finger; Region: zf-CHC2; cl17510 405566003354 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 405566003355 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 405566003356 active site 405566003357 metal binding site [ion binding]; metal-binding site 405566003358 interdomain interaction site; other site 405566003359 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 405566003360 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 405566003361 DALR anticodon binding domain; Region: DALR_1; pfam05746 405566003362 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 405566003363 motif 1; other site 405566003364 dimer interface [polypeptide binding]; other site 405566003365 active site 405566003366 motif 2; other site 405566003367 motif 3; other site 405566003368 Recombination protein O N terminal; Region: RecO_N; pfam11967 405566003369 DNA repair protein RecO; Region: reco; TIGR00613 405566003370 Recombination protein O C terminal; Region: RecO_C; pfam02565 405566003371 GTPase Era; Reviewed; Region: era; PRK00089 405566003372 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 405566003373 G1 box; other site 405566003374 GTP/Mg2+ binding site [chemical binding]; other site 405566003375 Switch I region; other site 405566003376 G2 box; other site 405566003377 Switch II region; other site 405566003378 G3 box; other site 405566003379 G4 box; other site 405566003380 G5 box; other site 405566003381 metal-binding heat shock protein; Provisional; Region: PRK00016 405566003382 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 405566003383 PhoH-like protein; Region: PhoH; pfam02562 405566003384 Yqey-like protein; Region: YqeY; pfam09424 405566003385 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 405566003386 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 405566003387 Peptidase family M23; Region: Peptidase_M23; pfam01551 405566003388 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405566003389 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405566003390 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405566003391 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405566003392 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 405566003393 Helix-turn-helix domain; Region: HTH_38; pfam13936 405566003394 Integrase core domain; Region: rve; pfam00665 405566003395 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405566003396 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405566003397 dimerization interface [polypeptide binding]; other site 405566003398 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 405566003399 Sterol carrier protein domain; Region: SCP2_2; pfam13530 405566003400 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 405566003401 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405566003402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405566003403 Probable transposase; Region: OrfB_IS605; pfam01385 405566003404 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566003405 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 405566003406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405566003407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405566003408 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405566003409 dimerization interface [polypeptide binding]; other site 405566003410 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 405566003411 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 405566003412 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405566003413 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405566003414 motif II; other site 405566003415 Bacterial surface layer protein; Region: SLAP; pfam03217 405566003416 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 405566003417 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 405566003418 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405566003419 putative active site [active] 405566003420 catalytic site [active] 405566003421 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405566003422 putative active site [active] 405566003423 catalytic site [active] 405566003424 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 405566003425 conserved cys residue [active] 405566003426 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 405566003427 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 405566003428 dimer interface [polypeptide binding]; other site 405566003429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405566003430 catalytic residue [active] 405566003431 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405566003432 active site 405566003433 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 405566003434 DHH family; Region: DHH; pfam01368 405566003435 DHHA1 domain; Region: DHHA1; pfam02272 405566003436 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 405566003437 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 405566003438 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 405566003439 active site 405566003440 catalytic site [active] 405566003441 GTP-binding protein LepA; Provisional; Region: PRK05433 405566003442 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 405566003443 G1 box; other site 405566003444 putative GEF interaction site [polypeptide binding]; other site 405566003445 GTP/Mg2+ binding site [chemical binding]; other site 405566003446 Switch I region; other site 405566003447 G2 box; other site 405566003448 G3 box; other site 405566003449 Switch II region; other site 405566003450 G4 box; other site 405566003451 G5 box; other site 405566003452 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 405566003453 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 405566003454 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 405566003455 chaperone protein DnaJ; Provisional; Region: PRK14276 405566003456 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 405566003457 HSP70 interaction site [polypeptide binding]; other site 405566003458 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 405566003459 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 405566003460 dimer interface [polypeptide binding]; other site 405566003461 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 405566003462 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 405566003463 nucleotide binding site [chemical binding]; other site 405566003464 NEF interaction site [polypeptide binding]; other site 405566003465 SBD interface [polypeptide binding]; other site 405566003466 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 405566003467 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 405566003468 active site 405566003469 Riboflavin kinase; Region: Flavokinase; smart00904 405566003470 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 405566003471 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 405566003472 RNA binding site [nucleotide binding]; other site 405566003473 active site 405566003474 ribosome-binding factor A; Provisional; Region: PRK13818 405566003475 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 405566003476 translation initiation factor IF-2; Region: IF-2; TIGR00487 405566003477 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 405566003478 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 405566003479 G1 box; other site 405566003480 putative GEF interaction site [polypeptide binding]; other site 405566003481 GTP/Mg2+ binding site [chemical binding]; other site 405566003482 Switch I region; other site 405566003483 G2 box; other site 405566003484 G3 box; other site 405566003485 Switch II region; other site 405566003486 G4 box; other site 405566003487 G5 box; other site 405566003488 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 405566003489 Translation-initiation factor 2; Region: IF-2; pfam11987 405566003490 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 405566003491 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 405566003492 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 405566003493 putative RNA binding cleft [nucleotide binding]; other site 405566003494 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 405566003495 NusA N-terminal domain; Region: NusA_N; pfam08529 405566003496 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 405566003497 RNA binding site [nucleotide binding]; other site 405566003498 homodimer interface [polypeptide binding]; other site 405566003499 NusA-like KH domain; Region: KH_5; pfam13184 405566003500 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 405566003501 G-X-X-G motif; other site 405566003502 ribosome maturation protein RimP; Reviewed; Region: PRK00092 405566003503 Sm and related proteins; Region: Sm_like; cl00259 405566003504 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 405566003505 putative oligomer interface [polypeptide binding]; other site 405566003506 putative RNA binding site [nucleotide binding]; other site 405566003507 DNA polymerase III PolC; Validated; Region: polC; PRK00448 405566003508 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 405566003509 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 405566003510 generic binding surface II; other site 405566003511 generic binding surface I; other site 405566003512 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 405566003513 active site 405566003514 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 405566003515 active site 405566003516 catalytic site [active] 405566003517 substrate binding site [chemical binding]; other site 405566003518 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 405566003519 prolyl-tRNA synthetase; Provisional; Region: PRK09194 405566003520 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 405566003521 dimer interface [polypeptide binding]; other site 405566003522 motif 1; other site 405566003523 active site 405566003524 motif 2; other site 405566003525 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 405566003526 putative deacylase active site [active] 405566003527 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 405566003528 active site 405566003529 motif 3; other site 405566003530 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 405566003531 anticodon binding site; other site 405566003532 RIP metalloprotease RseP; Region: TIGR00054 405566003533 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 405566003534 active site 405566003535 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 405566003536 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 405566003537 protein binding site [polypeptide binding]; other site 405566003538 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 405566003539 putative substrate binding region [chemical binding]; other site 405566003540 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 405566003541 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 405566003542 catalytic residue [active] 405566003543 putative FPP diphosphate binding site; other site 405566003544 putative FPP binding hydrophobic cleft; other site 405566003545 dimer interface [polypeptide binding]; other site 405566003546 putative IPP diphosphate binding site; other site 405566003547 ribosome recycling factor; Reviewed; Region: frr; PRK00083 405566003548 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 405566003549 hinge region; other site 405566003550 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 405566003551 putative nucleotide binding site [chemical binding]; other site 405566003552 uridine monophosphate binding site [chemical binding]; other site 405566003553 homohexameric interface [polypeptide binding]; other site 405566003554 elongation factor Ts; Provisional; Region: tsf; PRK09377 405566003555 UBA/TS-N domain; Region: UBA; pfam00627 405566003556 Elongation factor TS; Region: EF_TS; pfam00889 405566003557 Elongation factor TS; Region: EF_TS; pfam00889 405566003558 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 405566003559 rRNA interaction site [nucleotide binding]; other site 405566003560 S8 interaction site; other site 405566003561 putative laminin-1 binding site; other site 405566003562 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 405566003563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405566003564 S-adenosylmethionine binding site [chemical binding]; other site 405566003565 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 405566003566 GIY-YIG motif/motif A; other site 405566003567 putative active site [active] 405566003568 putative metal binding site [ion binding]; other site 405566003569 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 405566003570 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 405566003571 putative acyl-acceptor binding pocket; other site 405566003572 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 405566003573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405566003574 S-adenosylmethionine binding site [chemical binding]; other site 405566003575 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 405566003576 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 405566003577 active site 405566003578 Zn binding site [ion binding]; other site 405566003579 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566003580 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566003581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 405566003582 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 405566003583 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405566003584 putative DNA binding site [nucleotide binding]; other site 405566003585 LexA repressor; Validated; Region: PRK00215 405566003586 putative Zn2+ binding site [ion binding]; other site 405566003587 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 405566003588 Catalytic site [active] 405566003589 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 405566003590 active site 405566003591 catalytic triad [active] 405566003592 oxyanion hole [active] 405566003593 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 405566003594 active site 405566003595 Fe-S cluster binding site [ion binding]; other site 405566003596 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 405566003597 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 405566003598 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 405566003599 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 405566003600 RimM N-terminal domain; Region: RimM; pfam01782 405566003601 PRC-barrel domain; Region: PRC; pfam05239 405566003602 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 405566003603 signal recognition particle protein; Provisional; Region: PRK10867 405566003604 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 405566003605 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 405566003606 P loop; other site 405566003607 GTP binding site [chemical binding]; other site 405566003608 Signal peptide binding domain; Region: SRP_SPB; pfam02978 405566003609 putative DNA-binding protein; Validated; Region: PRK00118 405566003610 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 405566003611 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 405566003612 Integrase core domain; Region: rve; pfam00665 405566003613 amino acid transporter; Region: 2A0306; TIGR00909 405566003614 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 405566003615 Peptidase family C69; Region: Peptidase_C69; pfam03577 405566003616 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 405566003617 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 405566003618 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 405566003619 P loop; other site 405566003620 GTP binding site [chemical binding]; other site 405566003621 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 405566003622 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 405566003623 Walker A/P-loop; other site 405566003624 ATP binding site [chemical binding]; other site 405566003625 Q-loop/lid; other site 405566003626 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 405566003627 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 405566003628 ABC transporter signature motif; other site 405566003629 Walker B; other site 405566003630 D-loop; other site 405566003631 H-loop/switch region; other site 405566003632 ribonuclease III; Reviewed; Region: rnc; PRK00102 405566003633 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 405566003634 dimerization interface [polypeptide binding]; other site 405566003635 active site 405566003636 metal binding site [ion binding]; metal-binding site 405566003637 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 405566003638 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 405566003639 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 405566003640 peptide binding site [polypeptide binding]; other site 405566003641 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405566003642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566003643 dimer interface [polypeptide binding]; other site 405566003644 conserved gate region; other site 405566003645 putative PBP binding loops; other site 405566003646 ABC-ATPase subunit interface; other site 405566003647 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405566003648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566003649 dimer interface [polypeptide binding]; other site 405566003650 conserved gate region; other site 405566003651 putative PBP binding loops; other site 405566003652 ABC-ATPase subunit interface; other site 405566003653 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405566003654 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 405566003655 Walker A/P-loop; other site 405566003656 ATP binding site [chemical binding]; other site 405566003657 Q-loop/lid; other site 405566003658 ABC transporter signature motif; other site 405566003659 Walker B; other site 405566003660 D-loop; other site 405566003661 H-loop/switch region; other site 405566003662 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405566003663 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405566003664 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405566003665 Walker A/P-loop; other site 405566003666 ATP binding site [chemical binding]; other site 405566003667 Q-loop/lid; other site 405566003668 ABC transporter signature motif; other site 405566003669 Walker B; other site 405566003670 D-loop; other site 405566003671 H-loop/switch region; other site 405566003672 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405566003673 acyl carrier protein; Provisional; Region: acpP; PRK00982 405566003674 putative phosphate acyltransferase; Provisional; Region: PRK05331 405566003675 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 405566003676 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 405566003677 ssDNA binding site; other site 405566003678 generic binding surface II; other site 405566003679 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405566003680 ATP binding site [chemical binding]; other site 405566003681 putative Mg++ binding site [ion binding]; other site 405566003682 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405566003683 nucleotide binding region [chemical binding]; other site 405566003684 ATP-binding site [chemical binding]; other site 405566003685 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 405566003686 DAK2 domain; Region: Dak2; pfam02734 405566003687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 405566003688 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 405566003689 SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins...; Region: SOCS; cl02533 405566003690 Thiamine pyrophosphokinase; Region: TPK; cd07995 405566003691 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 405566003692 active site 405566003693 dimerization interface [polypeptide binding]; other site 405566003694 thiamine binding site [chemical binding]; other site 405566003695 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 405566003696 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 405566003697 substrate binding site [chemical binding]; other site 405566003698 hexamer interface [polypeptide binding]; other site 405566003699 metal binding site [ion binding]; metal-binding site 405566003700 GTPase RsgA; Reviewed; Region: PRK00098 405566003701 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 405566003702 RNA binding site [nucleotide binding]; other site 405566003703 homodimer interface [polypeptide binding]; other site 405566003704 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 405566003705 GTPase/Zn-binding domain interface [polypeptide binding]; other site 405566003706 GTP/Mg2+ binding site [chemical binding]; other site 405566003707 G4 box; other site 405566003708 G5 box; other site 405566003709 G1 box; other site 405566003710 Switch I region; other site 405566003711 G2 box; other site 405566003712 G3 box; other site 405566003713 Switch II region; other site 405566003714 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 405566003715 Catalytic domain of Protein Kinases; Region: PKc; cd00180 405566003716 active site 405566003717 ATP binding site [chemical binding]; other site 405566003718 substrate binding site [chemical binding]; other site 405566003719 activation loop (A-loop); other site 405566003720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 405566003721 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 405566003722 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 405566003723 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 405566003724 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 405566003725 Protein phosphatase 2C; Region: PP2C; pfam00481 405566003726 active site 405566003727 16S rRNA methyltransferase B; Provisional; Region: PRK14902 405566003728 NusB family; Region: NusB; pfam01029 405566003729 putative RNA binding site [nucleotide binding]; other site 405566003730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405566003731 S-adenosylmethionine binding site [chemical binding]; other site 405566003732 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 405566003733 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 405566003734 putative active site [active] 405566003735 substrate binding site [chemical binding]; other site 405566003736 putative cosubstrate binding site; other site 405566003737 catalytic site [active] 405566003738 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 405566003739 substrate binding site [chemical binding]; other site 405566003740 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 405566003741 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405566003742 ATP binding site [chemical binding]; other site 405566003743 putative Mg++ binding site [ion binding]; other site 405566003744 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405566003745 nucleotide binding region [chemical binding]; other site 405566003746 ATP-binding site [chemical binding]; other site 405566003747 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 405566003748 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 405566003749 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 405566003750 catalytic site [active] 405566003751 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 405566003752 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 405566003753 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 405566003754 Walker A/P-loop; other site 405566003755 ATP binding site [chemical binding]; other site 405566003756 Q-loop/lid; other site 405566003757 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 405566003758 ABC transporter signature motif; other site 405566003759 Walker B; other site 405566003760 D-loop; other site 405566003761 H-loop/switch region; other site 405566003762 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 405566003763 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 405566003764 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 405566003765 generic binding surface II; other site 405566003766 generic binding surface I; other site 405566003767 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 405566003768 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 405566003769 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 405566003770 homodimer interface [polypeptide binding]; other site 405566003771 NADP binding site [chemical binding]; other site 405566003772 substrate binding site [chemical binding]; other site 405566003773 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 405566003774 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 405566003775 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 405566003776 homodimer interface [polypeptide binding]; other site 405566003777 NADP binding site [chemical binding]; other site 405566003778 substrate binding site [chemical binding]; other site 405566003779 transcription antitermination factor NusB; Region: nusB; TIGR01951 405566003780 putative RNA binding site [nucleotide binding]; other site 405566003781 Asp23 family; Region: Asp23; pfam03780 405566003782 elongation factor P; Validated; Region: PRK00529 405566003783 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 405566003784 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 405566003785 RNA binding site [nucleotide binding]; other site 405566003786 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 405566003787 RNA binding site [nucleotide binding]; other site 405566003788 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 405566003789 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 405566003790 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 405566003791 active site 405566003792 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 405566003793 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 405566003794 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 405566003795 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 405566003796 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 405566003797 homodimer interface [polypeptide binding]; other site 405566003798 substrate-cofactor binding pocket; other site 405566003799 catalytic residue [active] 405566003800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405566003801 Probable transposase; Region: OrfB_IS605; pfam01385 405566003802 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566003803 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 405566003804 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 405566003805 DNA binding residues [nucleotide binding] 405566003806 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 405566003807 catalytic residues [active] 405566003808 catalytic nucleophile [active] 405566003809 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 405566003810 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566003811 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566003812 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 405566003813 active site 1 [active] 405566003814 dimer interface [polypeptide binding]; other site 405566003815 hexamer interface [polypeptide binding]; other site 405566003816 active site 2 [active] 405566003817 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 405566003818 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 405566003819 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 405566003820 active site 405566003821 Bacterial surface layer protein; Region: SLAP; pfam03217 405566003822 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 405566003823 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 405566003824 substrate binding pocket [chemical binding]; other site 405566003825 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 405566003826 ArsC family; Region: ArsC; pfam03960 405566003827 putative ArsC-like catalytic residues; other site 405566003828 putative TRX-like catalytic residues [active] 405566003829 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 405566003830 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 405566003831 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 405566003832 methionine sulfoxide reductase B; Provisional; Region: PRK00222 405566003833 Sugar transport protein; Region: Sugar_transport; pfam06800 405566003834 EamA-like transporter family; Region: EamA; cl17759 405566003835 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 405566003836 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405566003837 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 405566003838 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 405566003839 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405566003840 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405566003841 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 405566003842 IMP binding site; other site 405566003843 dimer interface [polypeptide binding]; other site 405566003844 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 405566003845 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 405566003846 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 405566003847 catalytic site [active] 405566003848 subunit interface [polypeptide binding]; other site 405566003849 dihydroorotase; Validated; Region: pyrC; PRK09357 405566003850 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405566003851 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 405566003852 active site 405566003853 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 405566003854 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 405566003855 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 405566003856 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 405566003857 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405566003858 active site 405566003859 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 405566003860 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 405566003861 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 405566003862 heterodimer interface [polypeptide binding]; other site 405566003863 active site 405566003864 FMN binding site [chemical binding]; other site 405566003865 homodimer interface [polypeptide binding]; other site 405566003866 substrate binding site [chemical binding]; other site 405566003867 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 405566003868 active site 405566003869 dimer interface [polypeptide binding]; other site 405566003870 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405566003871 active site 405566003872 fragment of insertion sequence IS1201 405566003873 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566003874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405566003875 putative substrate translocation pore; other site 405566003876 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 405566003877 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 405566003878 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 405566003879 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 405566003880 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 405566003881 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405566003882 NlpC/P60 family; Region: NLPC_P60; cl17555 405566003883 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 405566003884 putative active site [active] 405566003885 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 405566003886 HsdM N-terminal domain; Region: HsdM_N; pfam12161 405566003887 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 405566003888 Methyltransferase domain; Region: Methyltransf_26; pfam13659 405566003889 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 405566003890 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405566003891 ATP binding site [chemical binding]; other site 405566003892 putative Mg++ binding site [ion binding]; other site 405566003893 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 405566003894 Double zinc ribbon; Region: DZR; pfam12773 405566003895 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566003896 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566003897 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 405566003898 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405566003899 active site 405566003900 catalytic tetrad [active] 405566003901 OsmC-like protein; Region: OsmC; pfam02566 405566003902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405566003903 putative substrate translocation pore; other site 405566003904 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405566003905 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 405566003906 active site 405566003907 catalytic residues [active] 405566003908 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 405566003909 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 405566003910 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 405566003911 galactokinase; Provisional; Region: PRK05322 405566003912 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 405566003913 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 405566003914 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405566003915 active site 405566003916 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405566003917 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405566003918 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405566003919 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 405566003920 active site 405566003921 metal binding site [ion binding]; metal-binding site 405566003922 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405566003923 benzoate transport; Region: 2A0115; TIGR00895 405566003924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405566003925 putative substrate translocation pore; other site 405566003926 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 405566003927 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 405566003928 ligand binding site [chemical binding]; other site 405566003929 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 405566003930 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405566003931 Walker A/P-loop; other site 405566003932 ATP binding site [chemical binding]; other site 405566003933 Q-loop/lid; other site 405566003934 ABC transporter signature motif; other site 405566003935 Walker B; other site 405566003936 D-loop; other site 405566003937 H-loop/switch region; other site 405566003938 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405566003939 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405566003940 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 405566003941 TM-ABC transporter signature motif; other site 405566003942 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405566003943 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 405566003944 TM-ABC transporter signature motif; other site 405566003945 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 405566003946 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 405566003947 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 405566003948 putative active site [active] 405566003949 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 405566003950 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405566003951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566003952 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566003953 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 405566003954 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 405566003955 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 405566003956 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 405566003957 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 405566003958 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 405566003959 active site 405566003960 substrate binding site [chemical binding]; other site 405566003961 cosubstrate binding site; other site 405566003962 catalytic site [active] 405566003963 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 405566003964 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 405566003965 purine monophosphate binding site [chemical binding]; other site 405566003966 dimer interface [polypeptide binding]; other site 405566003967 putative catalytic residues [active] 405566003968 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 405566003969 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 405566003970 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 405566003971 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 405566003972 dimerization interface [polypeptide binding]; other site 405566003973 putative ATP binding site [chemical binding]; other site 405566003974 amidophosphoribosyltransferase; Provisional; Region: PRK07272 405566003975 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 405566003976 active site 405566003977 tetramer interface [polypeptide binding]; other site 405566003978 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405566003979 active site 405566003980 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 405566003981 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 405566003982 dimerization interface [polypeptide binding]; other site 405566003983 ATP binding site [chemical binding]; other site 405566003984 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 405566003985 dimerization interface [polypeptide binding]; other site 405566003986 ATP binding site [chemical binding]; other site 405566003987 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 405566003988 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 405566003989 putative active site [active] 405566003990 catalytic triad [active] 405566003991 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 405566003992 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 405566003993 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 405566003994 ATP binding site [chemical binding]; other site 405566003995 active site 405566003996 substrate binding site [chemical binding]; other site 405566003997 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 405566003998 ATP-grasp domain; Region: ATP-grasp; pfam02222 405566003999 AIR carboxylase; Region: AIRC; pfam00731 405566004000 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 405566004001 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 405566004002 Potassium binding sites [ion binding]; other site 405566004003 Cesium cation binding sites [ion binding]; other site 405566004004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405566004005 putative substrate translocation pore; other site 405566004006 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405566004007 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 405566004008 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 405566004009 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 405566004010 shikimate binding site; other site 405566004011 NAD(P) binding site [chemical binding]; other site 405566004012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405566004013 HTH-like domain; Region: HTH_21; pfam13276 405566004014 Integrase core domain; Region: rve; pfam00665 405566004015 Integrase core domain; Region: rve_2; pfam13333 405566004016 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 405566004017 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 405566004018 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 405566004019 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 405566004020 HPr interaction site; other site 405566004021 glycerol kinase (GK) interaction site [polypeptide binding]; other site 405566004022 active site 405566004023 phosphorylation site [posttranslational modification] 405566004024 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405566004025 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405566004026 DNA binding site [nucleotide binding] 405566004027 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 405566004028 putative dimerization interface [polypeptide binding]; other site 405566004029 putative ligand binding site [chemical binding]; other site 405566004030 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566004031 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 405566004032 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 405566004033 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 405566004034 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 405566004035 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 405566004036 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 405566004037 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 405566004038 NAD binding site [chemical binding]; other site 405566004039 homodimer interface [polypeptide binding]; other site 405566004040 active site 405566004041 substrate binding site [chemical binding]; other site 405566004042 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 405566004043 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 405566004044 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 405566004045 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 405566004046 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 405566004047 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405566004048 active site residue [active] 405566004049 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 405566004050 Rhomboid family; Region: Rhomboid; pfam01694 405566004051 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 405566004052 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 405566004053 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 405566004054 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405566004055 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405566004056 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405566004057 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 405566004058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405566004059 non-specific DNA binding site [nucleotide binding]; other site 405566004060 salt bridge; other site 405566004061 sequence-specific DNA binding site [nucleotide binding]; other site 405566004062 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 405566004063 NAD(P) binding site [chemical binding]; other site 405566004064 LDH/MDH dimer interface [polypeptide binding]; other site 405566004065 substrate binding site [chemical binding]; other site 405566004066 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 405566004067 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 405566004068 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 405566004069 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 405566004070 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 405566004071 putative tRNA-binding site [nucleotide binding]; other site 405566004072 B3/4 domain; Region: B3_4; pfam03483 405566004073 tRNA synthetase B5 domain; Region: B5; smart00874 405566004074 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 405566004075 dimer interface [polypeptide binding]; other site 405566004076 motif 1; other site 405566004077 motif 3; other site 405566004078 motif 2; other site 405566004079 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 405566004080 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 405566004081 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 405566004082 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 405566004083 dimer interface [polypeptide binding]; other site 405566004084 motif 1; other site 405566004085 active site 405566004086 motif 2; other site 405566004087 motif 3; other site 405566004088 Predicted transcriptional regulators [Transcription]; Region: COG1733 405566004089 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405566004090 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 405566004091 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 405566004092 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 405566004093 Acylphosphatase; Region: Acylphosphatase; pfam00708 405566004094 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 405566004095 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 405566004096 putative deacylase active site [active] 405566004097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405566004098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405566004099 dimerization interface [polypeptide binding]; other site 405566004100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405566004101 dimer interface [polypeptide binding]; other site 405566004102 phosphorylation site [posttranslational modification] 405566004103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405566004104 ATP binding site [chemical binding]; other site 405566004105 Mg2+ binding site [ion binding]; other site 405566004106 G-X-G motif; other site 405566004107 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405566004108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405566004109 active site 405566004110 phosphorylation site [posttranslational modification] 405566004111 intermolecular recognition site; other site 405566004112 dimerization interface [polypeptide binding]; other site 405566004113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405566004114 DNA binding site [nucleotide binding] 405566004115 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 405566004116 hypothetical protein; Provisional; Region: PRK13670 405566004117 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 405566004118 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 405566004119 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405566004120 Zn2+ binding site [ion binding]; other site 405566004121 Mg2+ binding site [ion binding]; other site 405566004122 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 405566004123 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 405566004124 active site 405566004125 (T/H)XGH motif; other site 405566004126 GTPase YqeH; Provisional; Region: PRK13796 405566004127 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 405566004128 GTP/Mg2+ binding site [chemical binding]; other site 405566004129 G4 box; other site 405566004130 G5 box; other site 405566004131 G1 box; other site 405566004132 Switch I region; other site 405566004133 G2 box; other site 405566004134 G3 box; other site 405566004135 Switch II region; other site 405566004136 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 405566004137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405566004138 active site 405566004139 motif I; other site 405566004140 motif II; other site 405566004141 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 405566004142 23S rRNA binding site [nucleotide binding]; other site 405566004143 L21 binding site [polypeptide binding]; other site 405566004144 L13 binding site [polypeptide binding]; other site 405566004145 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 405566004146 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 405566004147 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 405566004148 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 405566004149 Domain of unknown function (DUF389); Region: DUF389; pfam04087 405566004150 Family description; Region: ACT_7; pfam13840 405566004151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405566004152 Probable transposase; Region: OrfB_IS605; pfam01385 405566004153 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566004154 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 405566004155 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 405566004156 DNA binding residues [nucleotide binding] 405566004157 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 405566004158 catalytic residues [active] 405566004159 catalytic nucleophile [active] 405566004160 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 405566004161 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 405566004162 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405566004163 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 405566004164 active site 405566004165 dimer interface [polypeptide binding]; other site 405566004166 motif 1; other site 405566004167 motif 2; other site 405566004168 motif 3; other site 405566004169 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 405566004170 anticodon binding site; other site 405566004171 primosomal protein DnaI; Reviewed; Region: PRK08939 405566004172 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 405566004173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405566004174 Walker A motif; other site 405566004175 ATP binding site [chemical binding]; other site 405566004176 Walker B motif; other site 405566004177 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 405566004178 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405566004179 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 405566004180 ATP cone domain; Region: ATP-cone; pfam03477 405566004181 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 405566004182 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 405566004183 CoA-binding site [chemical binding]; other site 405566004184 ATP-binding [chemical binding]; other site 405566004185 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 405566004186 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 405566004187 DNA binding site [nucleotide binding] 405566004188 catalytic residue [active] 405566004189 H2TH interface [polypeptide binding]; other site 405566004190 putative catalytic residues [active] 405566004191 turnover-facilitating residue; other site 405566004192 intercalation triad [nucleotide binding]; other site 405566004193 8OG recognition residue [nucleotide binding]; other site 405566004194 putative reading head residues; other site 405566004195 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 405566004196 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 405566004197 DNA polymerase I; Provisional; Region: PRK05755 405566004198 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 405566004199 active site 405566004200 metal binding site 1 [ion binding]; metal-binding site 405566004201 putative 5' ssDNA interaction site; other site 405566004202 metal binding site 3; metal-binding site 405566004203 metal binding site 2 [ion binding]; metal-binding site 405566004204 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 405566004205 putative DNA binding site [nucleotide binding]; other site 405566004206 putative metal binding site [ion binding]; other site 405566004207 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 405566004208 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 405566004209 active site 405566004210 DNA binding site [nucleotide binding] 405566004211 catalytic site [active] 405566004212 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 405566004213 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 405566004214 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 405566004215 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 405566004216 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 405566004217 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 405566004218 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 405566004219 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 405566004220 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 405566004221 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405566004222 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 405566004223 HflC protein; Region: hflC; TIGR01932 405566004224 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 405566004225 RelB antitoxin; Region: RelB; cl01171 405566004226 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 405566004227 Zn binding site [ion binding]; other site 405566004228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566004229 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566004230 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 405566004231 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405566004232 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405566004233 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405566004234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 405566004235 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405566004236 HTH-like domain; Region: HTH_21; pfam13276 405566004237 Integrase core domain; Region: rve; pfam00665 405566004238 Integrase core domain; Region: rve_2; pfam13333 405566004239 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566004240 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566004241 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 405566004242 putative tRNA-binding site [nucleotide binding]; other site 405566004243 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405566004244 catalytic residues [active] 405566004245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405566004246 S-adenosylmethionine binding site [chemical binding]; other site 405566004247 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 405566004248 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405566004249 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405566004250 Walker A/P-loop; other site 405566004251 ATP binding site [chemical binding]; other site 405566004252 Q-loop/lid; other site 405566004253 ABC transporter signature motif; other site 405566004254 Walker B; other site 405566004255 D-loop; other site 405566004256 H-loop/switch region; other site 405566004257 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405566004258 non-specific DNA binding site [nucleotide binding]; other site 405566004259 salt bridge; other site 405566004260 sequence-specific DNA binding site [nucleotide binding]; other site 405566004261 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 405566004262 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 405566004263 HIT family signature motif; other site 405566004264 catalytic residue [active] 405566004265 YtxH-like protein; Region: YtxH; cl02079 405566004266 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 405566004267 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 405566004268 PAS domain; Region: PAS_10; pfam13596 405566004269 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 405566004270 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 405566004271 generic binding surface I; other site 405566004272 generic binding surface II; other site 405566004273 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405566004274 Zn2+ binding site [ion binding]; other site 405566004275 Mg2+ binding site [ion binding]; other site 405566004276 P-loop containing region of AAA domain; Region: AAA_29; cl17516 405566004277 AAA domain; Region: AAA_23; pfam13476 405566004278 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 405566004279 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 405566004280 active site 405566004281 metal binding site [ion binding]; metal-binding site 405566004282 DNA binding site [nucleotide binding] 405566004283 hypothetical protein; Provisional; Region: PRK13676 405566004284 Transglycosylase; Region: Transgly; pfam00912 405566004285 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405566004286 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405566004287 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 405566004288 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 405566004289 active site 405566004290 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 405566004291 amphipathic channel; other site 405566004292 Asn-Pro-Ala signature motifs; other site 405566004293 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 405566004294 EDD domain protein, DegV family; Region: DegV; TIGR00762 405566004295 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405566004296 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 405566004297 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566004298 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405566004299 fragment of insertion sequence ISLhe60 405566004300 PemK-like protein; Region: PemK; pfam02452 405566004301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405566004302 salt bridge; other site 405566004303 non-specific DNA binding site [nucleotide binding]; other site 405566004304 sequence-specific DNA binding site [nucleotide binding]; other site 405566004305 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405566004306 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 405566004307 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405566004308 Walker A/P-loop; other site 405566004309 ATP binding site [chemical binding]; other site 405566004310 Q-loop/lid; other site 405566004311 ABC transporter signature motif; other site 405566004312 Walker B; other site 405566004313 D-loop; other site 405566004314 H-loop/switch region; other site 405566004315 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405566004316 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405566004317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405566004318 Walker A/P-loop; other site 405566004319 ATP binding site [chemical binding]; other site 405566004320 Q-loop/lid; other site 405566004321 ABC transporter signature motif; other site 405566004322 Walker B; other site 405566004323 D-loop; other site 405566004324 H-loop/switch region; other site 405566004325 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566004326 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 405566004327 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566004328 MULE transposase domain; Region: MULE; pfam10551 405566004329 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 405566004330 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 405566004331 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566004332 MULE transposase domain; Region: MULE; pfam10551 405566004333 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 405566004334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405566004335 Walker A/P-loop; other site 405566004336 ATP binding site [chemical binding]; other site 405566004337 Q-loop/lid; other site 405566004338 ABC transporter signature motif; other site 405566004339 Walker B; other site 405566004340 D-loop; other site 405566004341 H-loop/switch region; other site 405566004342 WbqC-like protein family; Region: WbqC; pfam08889 405566004343 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405566004344 nudix motif; other site 405566004345 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 405566004346 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 405566004347 intersubunit interface [polypeptide binding]; other site 405566004348 active site 405566004349 zinc binding site [ion binding]; other site 405566004350 Na+ binding site [ion binding]; other site 405566004351 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 405566004352 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 405566004353 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 405566004354 active site 405566004355 HIGH motif; other site 405566004356 KMSK motif region; other site 405566004357 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 405566004358 tRNA binding surface [nucleotide binding]; other site 405566004359 anticodon binding site; other site 405566004360 Predicted transcriptional regulators [Transcription]; Region: COG1695 405566004361 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 405566004362 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 405566004363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 405566004364 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405566004365 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 405566004366 putative substrate binding site [chemical binding]; other site 405566004367 putative ATP binding site [chemical binding]; other site 405566004368 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405566004369 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405566004370 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 405566004371 PspC domain; Region: PspC; pfam04024 405566004372 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 405566004373 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 405566004374 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405566004375 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405566004376 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405566004377 dimerization interface [polypeptide binding]; other site 405566004378 putative DNA binding site [nucleotide binding]; other site 405566004379 putative Zn2+ binding site [ion binding]; other site 405566004380 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405566004381 active site residue [active] 405566004382 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405566004383 catalytic residues [active] 405566004384 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 405566004385 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405566004386 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 405566004387 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 405566004388 HIGH motif; other site 405566004389 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 405566004390 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 405566004391 active site 405566004392 KMSKS motif; other site 405566004393 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 405566004394 tRNA binding surface [nucleotide binding]; other site 405566004395 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 405566004396 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405566004397 active site 405566004398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405566004399 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405566004400 putative substrate translocation pore; other site 405566004401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405566004402 S-adenosylmethionine synthetase; Validated; Region: PRK05250 405566004403 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 405566004404 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 405566004405 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 405566004406 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 405566004407 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 405566004408 intersubunit interface [polypeptide binding]; other site 405566004409 seryl-tRNA synthetase; Provisional; Region: PRK05431 405566004410 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 405566004411 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 405566004412 dimer interface [polypeptide binding]; other site 405566004413 active site 405566004414 motif 1; other site 405566004415 motif 2; other site 405566004416 motif 3; other site 405566004417 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405566004418 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405566004419 Uncharacterized conserved protein [Function unknown]; Region: COG0398 405566004420 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405566004421 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 405566004422 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 405566004423 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 405566004424 NAD(P) binding site [chemical binding]; other site 405566004425 catalytic residues [active] 405566004426 Double zinc ribbon; Region: DZR; pfam12773 405566004427 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 405566004428 MMPL family; Region: MMPL; pfam03176 405566004429 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 405566004430 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 405566004431 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 405566004432 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 405566004433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405566004434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405566004435 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 405566004436 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 405566004437 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 405566004438 Cl binding site [ion binding]; other site 405566004439 oligomer interface [polypeptide binding]; other site 405566004440 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 405566004441 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 405566004442 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 405566004443 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 405566004444 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405566004445 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 405566004446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566004447 dimer interface [polypeptide binding]; other site 405566004448 conserved gate region; other site 405566004449 ABC-ATPase subunit interface; other site 405566004450 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 405566004451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566004452 dimer interface [polypeptide binding]; other site 405566004453 conserved gate region; other site 405566004454 putative PBP binding loops; other site 405566004455 ABC-ATPase subunit interface; other site 405566004456 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 405566004457 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 405566004458 Walker A/P-loop; other site 405566004459 ATP binding site [chemical binding]; other site 405566004460 Q-loop/lid; other site 405566004461 ABC transporter signature motif; other site 405566004462 Walker B; other site 405566004463 D-loop; other site 405566004464 H-loop/switch region; other site 405566004465 TOBE domain; Region: TOBE_2; pfam08402 405566004466 Peptidase family C69; Region: Peptidase_C69; pfam03577 405566004467 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 405566004468 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 405566004469 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 405566004470 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 405566004471 active site 405566004472 catalytic site [active] 405566004473 substrate binding site [chemical binding]; other site 405566004474 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 405566004475 Probable transposase; Region: OrfB_IS605; pfam01385 405566004476 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566004477 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405566004478 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 405566004479 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 405566004480 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 405566004481 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405566004482 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405566004483 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 405566004484 Walker A/P-loop; other site 405566004485 ATP binding site [chemical binding]; other site 405566004486 Q-loop/lid; other site 405566004487 ABC transporter signature motif; other site 405566004488 Walker B; other site 405566004489 D-loop; other site 405566004490 H-loop/switch region; other site 405566004491 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 405566004492 adenosine deaminase; Provisional; Region: PRK09358 405566004493 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 405566004494 active site 405566004495 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 405566004496 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 405566004497 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 405566004498 elongation factor P; Validated; Region: PRK00529 405566004499 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 405566004500 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 405566004501 RNA binding site [nucleotide binding]; other site 405566004502 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 405566004503 RNA binding site [nucleotide binding]; other site 405566004504 pantothenate kinase; Provisional; Region: PRK05439 405566004505 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 405566004506 ATP-binding site [chemical binding]; other site 405566004507 CoA-binding site [chemical binding]; other site 405566004508 Mg2+-binding site [ion binding]; other site 405566004509 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 405566004510 active site 405566004511 catalytic triad [active] 405566004512 oxyanion hole [active] 405566004513 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 405566004514 Part of AAA domain; Region: AAA_19; pfam13245 405566004515 Family description; Region: UvrD_C_2; pfam13538 405566004516 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 405566004517 active site 405566004518 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405566004519 catalytic core [active] 405566004520 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405566004521 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405566004522 Walker A/P-loop; other site 405566004523 ATP binding site [chemical binding]; other site 405566004524 Q-loop/lid; other site 405566004525 ABC transporter signature motif; other site 405566004526 Walker B; other site 405566004527 D-loop; other site 405566004528 H-loop/switch region; other site 405566004529 Predicted membrane protein [Function unknown]; Region: COG4640 405566004530 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 405566004531 active site 405566004532 homodimer interface [polypeptide binding]; other site 405566004533 fragment of insertion sequence ISLhe65 405566004534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405566004535 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405566004536 Coenzyme A binding pocket [chemical binding]; other site 405566004537 Beta-lactamase; Region: Beta-lactamase; pfam00144 405566004538 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405566004539 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 405566004540 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 405566004541 active site 405566004542 tetramer interface; other site 405566004543 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 405566004544 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 405566004545 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405566004546 catalytic residue [active] 405566004547 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 405566004548 Amino acid permease; Region: AA_permease_2; pfam13520 405566004549 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566004550 MULE transposase domain; Region: MULE; pfam10551 405566004551 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 405566004552 Helix-turn-helix domain; Region: HTH_38; pfam13936 405566004553 Integrase core domain; Region: rve; pfam00665 405566004554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566004555 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566004556 Core-2/I-Branching enzyme; Region: Branch; pfam02485 405566004557 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 405566004558 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405566004559 UDP-galactopyranose mutase; Region: GLF; pfam03275 405566004560 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 405566004561 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 405566004562 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 405566004563 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 405566004564 active site 405566004565 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 405566004566 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 405566004567 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405566004568 putative ADP-binding pocket [chemical binding]; other site 405566004569 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 405566004570 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 405566004571 putative ADP-binding pocket [chemical binding]; other site 405566004572 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 405566004573 Bacterial sugar transferase; Region: Bac_transf; pfam02397 405566004574 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 405566004575 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405566004576 active site 405566004577 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 405566004578 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405566004579 Chain length determinant protein; Region: Wzz; cl15801 405566004580 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 405566004581 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 405566004582 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 405566004583 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 405566004584 HflX GTPase family; Region: HflX; cd01878 405566004585 G1 box; other site 405566004586 GTP/Mg2+ binding site [chemical binding]; other site 405566004587 Switch I region; other site 405566004588 G2 box; other site 405566004589 G3 box; other site 405566004590 Switch II region; other site 405566004591 G4 box; other site 405566004592 G5 box; other site 405566004593 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566004594 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405566004595 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 405566004596 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 405566004597 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761 405566004598 DNA binding residues [nucleotide binding] 405566004599 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 405566004600 catalytic residues [active] 405566004601 catalytic nucleophile [active] 405566004602 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405566004603 NlpC/P60 family; Region: NLPC_P60; pfam00877 405566004604 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 405566004605 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 405566004606 active site 405566004607 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 405566004608 Probable transposase; Region: OrfB_IS605; pfam01385 405566004609 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566004610 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405566004611 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 405566004612 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 405566004613 putative active site [active] 405566004614 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 405566004615 Uncharacterized conserved protein [Function unknown]; Region: COG2966 405566004616 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 405566004617 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405566004618 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405566004619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405566004620 Walker A/P-loop; other site 405566004621 ATP binding site [chemical binding]; other site 405566004622 Q-loop/lid; other site 405566004623 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405566004624 ABC transporter signature motif; other site 405566004625 Walker B; other site 405566004626 D-loop; other site 405566004627 ABC transporter; Region: ABC_tran_2; pfam12848 405566004628 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405566004629 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 405566004630 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 405566004631 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 405566004632 active site 405566004633 Zn binding site [ion binding]; other site 405566004634 Fic family protein [Function unknown]; Region: COG3177 405566004635 Fic/DOC family; Region: Fic; pfam02661 405566004636 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 405566004637 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405566004638 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 405566004639 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 405566004640 dimer interface [polypeptide binding]; other site 405566004641 putative PBP binding regions; other site 405566004642 ABC-ATPase subunit interface; other site 405566004643 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405566004644 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 405566004645 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 405566004646 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 405566004647 intersubunit interface [polypeptide binding]; other site 405566004648 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405566004649 dimerization interface [polypeptide binding]; other site 405566004650 putative DNA binding site [nucleotide binding]; other site 405566004651 putative Zn2+ binding site [ion binding]; other site 405566004652 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 405566004653 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405566004654 active site 405566004655 phosphorylation site [posttranslational modification] 405566004656 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 405566004657 active site 405566004658 P-loop; other site 405566004659 phosphorylation site [posttranslational modification] 405566004660 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 405566004661 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 405566004662 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 405566004663 putative substrate binding site [chemical binding]; other site 405566004664 putative ATP binding site [chemical binding]; other site 405566004665 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405566004666 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 405566004667 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405566004668 RelB antitoxin; Region: RelB; cl01171 405566004669 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405566004670 salt bridge; other site 405566004671 non-specific DNA binding site [nucleotide binding]; other site 405566004672 sequence-specific DNA binding site [nucleotide binding]; other site 405566004673 Enterocin A Immunity; Region: EntA_Immun; pfam08951 405566004674 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 405566004675 aspartate racemase; Region: asp_race; TIGR00035 405566004676 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 405566004677 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405566004678 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405566004679 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405566004680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405566004681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405566004682 dimer interface [polypeptide binding]; other site 405566004683 phosphorylation site [posttranslational modification] 405566004684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405566004685 ATP binding site [chemical binding]; other site 405566004686 Mg2+ binding site [ion binding]; other site 405566004687 G-X-G motif; other site 405566004688 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405566004689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405566004690 active site 405566004691 phosphorylation site [posttranslational modification] 405566004692 intermolecular recognition site; other site 405566004693 dimerization interface [polypeptide binding]; other site 405566004694 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405566004695 DNA binding site [nucleotide binding] 405566004696 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405566004697 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405566004698 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 405566004699 Walker A/P-loop; other site 405566004700 ATP binding site [chemical binding]; other site 405566004701 Q-loop/lid; other site 405566004702 ABC transporter signature motif; other site 405566004703 Walker B; other site 405566004704 D-loop; other site 405566004705 H-loop/switch region; other site 405566004706 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405566004707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405566004708 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405566004709 Walker A/P-loop; other site 405566004710 ATP binding site [chemical binding]; other site 405566004711 Q-loop/lid; other site 405566004712 ABC transporter signature motif; other site 405566004713 Walker B; other site 405566004714 D-loop; other site 405566004715 H-loop/switch region; other site 405566004716 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566004717 MULE transposase domain; Region: MULE; pfam10551 405566004718 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405566004719 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405566004720 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566004721 MULE transposase domain; Region: MULE; pfam10551 405566004722 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 405566004723 GTP-binding protein YchF; Reviewed; Region: PRK09601 405566004724 YchF GTPase; Region: YchF; cd01900 405566004725 G1 box; other site 405566004726 GTP/Mg2+ binding site [chemical binding]; other site 405566004727 Switch I region; other site 405566004728 G2 box; other site 405566004729 Switch II region; other site 405566004730 G3 box; other site 405566004731 G4 box; other site 405566004732 G5 box; other site 405566004733 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 405566004734 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 405566004735 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 405566004736 ParB-like nuclease domain; Region: ParB; smart00470 405566004737 Helix-turn-helix; Region: HTH_3; pfam01381 405566004738 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 405566004739 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 405566004740 P-loop; other site 405566004741 Magnesium ion binding site [ion binding]; other site 405566004742 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 405566004743 Magnesium ion binding site [ion binding]; other site 405566004744 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 405566004745 ParB-like nuclease domain; Region: ParBc; pfam02195 405566004746 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 405566004747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405566004748 S-adenosylmethionine binding site [chemical binding]; other site 405566004749 Colicin V production protein; Region: Colicin_V; pfam02674 405566004750 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 405566004751 ApbE family; Region: ApbE; pfam02424 405566004752 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 405566004753 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 405566004754 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405566004755 WHG domain; Region: WHG; pfam13305 405566004756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405566004757 Probable transposase; Region: OrfB_IS605; pfam01385 405566004758 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566004759 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 405566004760 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 405566004761 DNA binding residues [nucleotide binding] 405566004762 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 405566004763 catalytic residues [active] 405566004764 catalytic nucleophile [active] 405566004765 Peptidase family C69; Region: Peptidase_C69; pfam03577 405566004766 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405566004767 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405566004768 Walker A/P-loop; other site 405566004769 ATP binding site [chemical binding]; other site 405566004770 Q-loop/lid; other site 405566004771 ABC transporter signature motif; other site 405566004772 Walker B; other site 405566004773 D-loop; other site 405566004774 H-loop/switch region; other site 405566004775 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405566004776 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405566004777 FtsX-like permease family; Region: FtsX; pfam02687 405566004778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405566004779 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405566004780 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405566004781 catalytic core [active] 405566004782 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 405566004783 hypothetical protein; Validated; Region: PRK02101 405566004784 Peptidase family M1; Region: Peptidase_M1; pfam01433 405566004785 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 405566004786 Zn binding site [ion binding]; other site 405566004787 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 405566004788 drug efflux system protein MdtG; Provisional; Region: PRK09874 405566004789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405566004790 putative substrate translocation pore; other site 405566004791 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405566004792 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405566004793 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 405566004794 Walker A/P-loop; other site 405566004795 ATP binding site [chemical binding]; other site 405566004796 Q-loop/lid; other site 405566004797 ABC transporter signature motif; other site 405566004798 Walker B; other site 405566004799 D-loop; other site 405566004800 H-loop/switch region; other site 405566004801 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 405566004802 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566004803 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 405566004804 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 405566004805 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 405566004806 Class I ribonucleotide reductase; Region: RNR_I; cd01679 405566004807 active site 405566004808 dimer interface [polypeptide binding]; other site 405566004809 catalytic residues [active] 405566004810 effector binding site; other site 405566004811 R2 peptide binding site; other site 405566004812 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 405566004813 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 405566004814 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 405566004815 dimer interface [polypeptide binding]; other site 405566004816 putative radical transfer pathway; other site 405566004817 diiron center [ion binding]; other site 405566004818 tyrosyl radical; other site 405566004819 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566004820 MULE transposase domain; Region: MULE; pfam10551 405566004821 serine O-acetyltransferase; Region: cysE; TIGR01172 405566004822 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 405566004823 trimer interface [polypeptide binding]; other site 405566004824 active site 405566004825 substrate binding site [chemical binding]; other site 405566004826 CoA binding site [chemical binding]; other site 405566004827 cystathionine beta-lyase; Provisional; Region: PRK07671 405566004828 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405566004829 homodimer interface [polypeptide binding]; other site 405566004830 substrate-cofactor binding pocket; other site 405566004831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405566004832 catalytic residue [active] 405566004833 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 405566004834 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 405566004835 dimer interface [polypeptide binding]; other site 405566004836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405566004837 catalytic residue [active] 405566004838 fragment of insertion sequence ISLhe15 405566004839 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 405566004840 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566004841 MULE transposase domain; Region: MULE; pfam10551 405566004842 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405566004843 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405566004844 non-specific DNA binding site [nucleotide binding]; other site 405566004845 salt bridge; other site 405566004846 sequence-specific DNA binding site [nucleotide binding]; other site 405566004847 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 405566004848 H+ Antiporter protein; Region: 2A0121; TIGR00900 405566004849 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405566004850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405566004851 non-specific DNA binding site [nucleotide binding]; other site 405566004852 salt bridge; other site 405566004853 sequence-specific DNA binding site [nucleotide binding]; other site 405566004854 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 405566004855 S-ribosylhomocysteinase; Provisional; Region: PRK02260 405566004856 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 405566004857 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 405566004858 THF binding site; other site 405566004859 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 405566004860 substrate binding site [chemical binding]; other site 405566004861 THF binding site; other site 405566004862 zinc-binding site [ion binding]; other site 405566004863 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 405566004864 FAD binding site [chemical binding]; other site 405566004865 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 405566004866 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405566004867 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405566004868 active site 405566004869 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 405566004870 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566004871 BioY family; Region: BioY; pfam02632 405566004872 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 405566004873 HTH domain; Region: HTH_11; pfam08279 405566004874 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 405566004875 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 405566004876 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 405566004877 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 405566004878 NAD binding site [chemical binding]; other site 405566004879 homotetramer interface [polypeptide binding]; other site 405566004880 homodimer interface [polypeptide binding]; other site 405566004881 substrate binding site [chemical binding]; other site 405566004882 active site 405566004883 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 405566004884 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 405566004885 FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764 405566004886 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 405566004887 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 405566004888 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405566004889 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405566004890 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 405566004891 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 405566004892 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 405566004893 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 405566004894 carboxyltransferase (CT) interaction site; other site 405566004895 biotinylation site [posttranslational modification]; other site 405566004896 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 405566004897 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 405566004898 dimer interface [polypeptide binding]; other site 405566004899 active site 405566004900 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 405566004901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405566004902 NAD(P) binding site [chemical binding]; other site 405566004903 active site 405566004904 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 405566004905 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 405566004906 acyl carrier protein; Provisional; Region: acpP; PRK00982 405566004907 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 405566004908 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 405566004909 dimer interface [polypeptide binding]; other site 405566004910 active site 405566004911 CoA binding pocket [chemical binding]; other site 405566004912 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 405566004913 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 405566004914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405566004915 Probable transposase; Region: OrfB_IS605; pfam01385 405566004916 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566004917 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 405566004918 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 405566004919 DNA binding residues [nucleotide binding] 405566004920 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 405566004921 catalytic residues [active] 405566004922 catalytic nucleophile [active] 405566004923 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 405566004924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566004925 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566004926 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 405566004927 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405566004928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405566004929 motif II; other site 405566004930 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 405566004931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405566004932 Coenzyme A binding pocket [chemical binding]; other site 405566004933 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566004934 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566004935 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 405566004936 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 405566004937 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 405566004938 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 405566004939 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 405566004940 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405566004941 Walker A/P-loop; other site 405566004942 ATP binding site [chemical binding]; other site 405566004943 Q-loop/lid; other site 405566004944 ABC transporter signature motif; other site 405566004945 Walker B; other site 405566004946 D-loop; other site 405566004947 H-loop/switch region; other site 405566004948 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405566004949 Walker A/P-loop; other site 405566004950 ATP binding site [chemical binding]; other site 405566004951 Q-loop/lid; other site 405566004952 ABC transporter signature motif; other site 405566004953 Walker B; other site 405566004954 D-loop; other site 405566004955 H-loop/switch region; other site 405566004956 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 405566004957 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 405566004958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405566004959 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405566004960 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 405566004961 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405566004962 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405566004963 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405566004964 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405566004965 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405566004966 Walker A/P-loop; other site 405566004967 ATP binding site [chemical binding]; other site 405566004968 Q-loop/lid; other site 405566004969 ABC transporter signature motif; other site 405566004970 Walker B; other site 405566004971 D-loop; other site 405566004972 H-loop/switch region; other site 405566004973 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405566004974 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405566004975 Walker A/P-loop; other site 405566004976 ATP binding site [chemical binding]; other site 405566004977 Q-loop/lid; other site 405566004978 ABC transporter signature motif; other site 405566004979 Walker B; other site 405566004980 D-loop; other site 405566004981 H-loop/switch region; other site 405566004982 Cobalt transport protein; Region: CbiQ; cl00463 405566004983 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 405566004984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405566004985 putative substrate translocation pore; other site 405566004986 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 405566004987 Helix-turn-helix domain; Region: HTH_38; pfam13936 405566004988 Integrase core domain; Region: rve; pfam00665 405566004989 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 405566004990 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 405566004991 active site 405566004992 zinc binding site [ion binding]; other site 405566004993 Mrr N-terminal domain; Region: Mrr_N; pfam14338 405566004994 Restriction endonuclease; Region: Mrr_cat; pfam04471 405566004995 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 405566004996 TRAM domain; Region: TRAM; pfam01938 405566004997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405566004998 S-adenosylmethionine binding site [chemical binding]; other site 405566004999 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 405566005000 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 405566005001 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 405566005002 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 405566005003 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 405566005004 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405566005005 substrate binding site [chemical binding]; other site 405566005006 ATP binding site [chemical binding]; other site 405566005007 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 405566005008 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566005009 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 405566005010 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 405566005011 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405566005012 fragment of insertion sequence ISLhe30 405566005013 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 405566005014 Integrase core domain; Region: rve; pfam00665 405566005015 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 405566005016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566005017 dimer interface [polypeptide binding]; other site 405566005018 conserved gate region; other site 405566005019 putative PBP binding loops; other site 405566005020 ABC-ATPase subunit interface; other site 405566005021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405566005022 dimer interface [polypeptide binding]; other site 405566005023 conserved gate region; other site 405566005024 ABC-ATPase subunit interface; other site 405566005025 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 405566005026 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 405566005027 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 405566005028 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 405566005029 Walker A/P-loop; other site 405566005030 ATP binding site [chemical binding]; other site 405566005031 Q-loop/lid; other site 405566005032 ABC transporter signature motif; other site 405566005033 Walker B; other site 405566005034 D-loop; other site 405566005035 H-loop/switch region; other site 405566005036 TOBE domain; Region: TOBE_2; pfam08402 405566005037 beta-phosphoglucomutase; Region: bPGM; TIGR01990 405566005038 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405566005039 motif II; other site 405566005040 maltose phosphorylase; Provisional; Region: PRK13807 405566005041 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 405566005042 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 405566005043 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 405566005044 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 405566005045 homodimer interface [polypeptide binding]; other site 405566005046 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 405566005047 active site 405566005048 homodimer interface [polypeptide binding]; other site 405566005049 catalytic site [active] 405566005050 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 405566005051 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 405566005052 Ca binding site [ion binding]; other site 405566005053 active site 405566005054 catalytic site [active] 405566005055 Acetokinase family; Region: Acetate_kinase; cl17229 405566005056 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 405566005057 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 405566005058 fragment of insertion sequence ISLhe15 405566005059 Fic/DOC family; Region: Fic; cl00960 405566005060 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566005061 MULE transposase domain; Region: MULE; pfam10551 405566005062 Fic family protein [Function unknown]; Region: COG3177 405566005063 Fic/DOC family; Region: Fic; pfam02661 405566005064 multiple promoter invertase; Provisional; Region: mpi; PRK13413 405566005065 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405566005066 catalytic residues [active] 405566005067 catalytic nucleophile [active] 405566005068 Presynaptic Site I dimer interface [polypeptide binding]; other site 405566005069 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405566005070 Synaptic Flat tetramer interface [polypeptide binding]; other site 405566005071 Synaptic Site I dimer interface [polypeptide binding]; other site 405566005072 DNA binding site [nucleotide binding] 405566005073 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 405566005074 dimer interface [polypeptide binding]; other site 405566005075 substrate binding site [chemical binding]; other site 405566005076 ATP binding site [chemical binding]; other site 405566005077 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 405566005078 catalytic triad [active] 405566005079 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405566005080 Helix-turn-helix domain; Region: HTH_28; pfam13518 405566005081 HTH-like domain; Region: HTH_21; pfam13276 405566005082 Integrase core domain; Region: rve; pfam00665 405566005083 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405566005084 NlpC/P60 family; Region: NLPC_P60; pfam00877 405566005085 EamA-like transporter family; Region: EamA; pfam00892 405566005086 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405566005087 EamA-like transporter family; Region: EamA; pfam00892 405566005088 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405566005089 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 405566005090 adenylosuccinate lyase; Provisional; Region: PRK07492 405566005091 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 405566005092 tetramer interface [polypeptide binding]; other site 405566005093 active site 405566005094 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 405566005095 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 405566005096 GDP-binding site [chemical binding]; other site 405566005097 ACT binding site; other site 405566005098 IMP binding site; other site 405566005099 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 405566005100 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 405566005101 active site 405566005102 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 405566005103 Uncharacterized conserved protein [Function unknown]; Region: COG3589 405566005104 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 405566005105 dimer interface [polypeptide binding]; other site 405566005106 active site 405566005107 Transposase, Mutator family; Region: Transposase_mut; pfam00872 405566005108 MULE transposase domain; Region: MULE; pfam10551 405566005109 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 405566005110 putative transport protein YifK; Provisional; Region: PRK10746 405566005111 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 405566005112 cAMP-dependent protein kinase catalytic subunit; Provisional; Region: PTZ00426 405566005113 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405566005114 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405566005115 Catalytic site [active] 405566005116 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405566005117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405566005118 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 405566005119 Walker A motif; other site 405566005120 ATP binding site [chemical binding]; other site 405566005121 Walker B motif; other site 405566005122 arginine finger; other site 405566005123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405566005124 Walker A motif; other site 405566005125 ATP binding site [chemical binding]; other site 405566005126 Walker B motif; other site 405566005127 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 405566005128 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 405566005129 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 405566005130 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405566005131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405566005132 Probable transposase; Region: OrfB_IS605; pfam01385 405566005133 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405566005134 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 405566005135 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 405566005136 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405566005137 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 405566005138 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 405566005139 active site 405566005140 Protein of unknown function (DUF975); Region: DUF975; cl10504 405566005141 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405566005142 Beta-lactamase; Region: Beta-lactamase; pfam00144 405566005143 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 405566005144 DltD N-terminal region; Region: DltD_N; pfam04915 405566005145 DltD central region; Region: DltD_M; pfam04918 405566005146 DltD C-terminal region; Region: DltD_C; pfam04914 405566005147 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 405566005148 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 405566005149 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 405566005150 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 405566005151 acyl-activating enzyme (AAE) consensus motif; other site 405566005152 AMP binding site [chemical binding]; other site 405566005153 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 405566005154 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405566005155 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405566005156 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405566005157 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405566005158 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 405566005159 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405566005160 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405566005161 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 405566005162 Walker A/P-loop; other site 405566005163 ATP binding site [chemical binding]; other site 405566005164 Q-loop/lid; other site 405566005165 ABC transporter signature motif; other site 405566005166 Walker B; other site 405566005167 D-loop; other site 405566005168 H-loop/switch region; other site 405566005169 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 405566005170 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 405566005171 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405566005172 non-specific DNA binding site [nucleotide binding]; other site 405566005173 salt bridge; other site 405566005174 sequence-specific DNA binding site [nucleotide binding]; other site 405566005175 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 405566005176 CAAX protease self-immunity; Region: Abi; pfam02517 405566005177 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405566005178 putative active site [active] 405566005179 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405566005180 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405566005181 active site 405566005182 catalytic tetrad [active] 405566005183 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 405566005184 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 405566005185 active site 405566005186 trimer interface [polypeptide binding]; other site 405566005187 allosteric site; other site 405566005188 active site lid [active] 405566005189 hexamer (dimer of trimers) interface [polypeptide binding]; other site 405566005190 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 405566005191 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 405566005192 Substrate-binding site [chemical binding]; other site 405566005193 Substrate specificity [chemical binding]; other site 405566005194 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 405566005195 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 405566005196 Substrate-binding site [chemical binding]; other site 405566005197 Substrate specificity [chemical binding]; other site 405566005198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 405566005199 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405566005200 active site 405566005201 motif I; other site 405566005202 motif II; other site 405566005203 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405566005204 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405566005205 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405566005206 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 405566005207 DNA binding residues [nucleotide binding] 405566005208 dimer interface [polypeptide binding]; other site 405566005209 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405566005210 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 405566005211 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 405566005212 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405566005213 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 405566005214 Penicillinase repressor; Region: Pencillinase_R; pfam03965 405566005215 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 405566005216 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 405566005217 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 405566005218 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405566005219 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405566005220 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 405566005221 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 405566005222 Cl- selectivity filter; other site 405566005223 Cl- binding residues [ion binding]; other site 405566005224 pore gating glutamate residue; other site 405566005225 dimer interface [polypeptide binding]; other site 405566005226 H+/Cl- coupling transport residue; other site 405566005227 TrkA-C domain; Region: TrkA_C; pfam02080 405566005228 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405566005229 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 405566005230 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 405566005231 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 405566005232 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 405566005233 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 405566005234 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 405566005235 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 405566005236 trmE is a tRNA modification GTPase; Region: trmE; cd04164 405566005237 G1 box; other site 405566005238 GTP/Mg2+ binding site [chemical binding]; other site 405566005239 Switch I region; other site 405566005240 G2 box; other site 405566005241 Switch II region; other site 405566005242 G3 box; other site 405566005243 G4 box; other site 405566005244 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 405566005245 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 405566005246 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 405566005247 ribonuclease P; Reviewed; Region: rnpA; PRK00499 405566005248 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399