-- dump date 20140619_123610 -- class Genbank::misc_feature -- table misc_feature_note -- id note 767462000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 767462000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 767462000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767462000004 Walker A motif; other site 767462000005 ATP binding site [chemical binding]; other site 767462000006 Walker B motif; other site 767462000007 arginine finger; other site 767462000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 767462000009 DnaA box-binding interface [nucleotide binding]; other site 767462000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 767462000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 767462000012 putative DNA binding surface [nucleotide binding]; other site 767462000013 dimer interface [polypeptide binding]; other site 767462000014 beta-clamp/clamp loader binding surface; other site 767462000015 beta-clamp/translesion DNA polymerase binding surface; other site 767462000016 S4 domain; Region: S4_2; pfam13275 767462000017 recombination protein F; Reviewed; Region: recF; PRK00064 767462000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 767462000019 Walker A/P-loop; other site 767462000020 ATP binding site [chemical binding]; other site 767462000021 Q-loop/lid; other site 767462000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462000023 ABC transporter signature motif; other site 767462000024 Walker B; other site 767462000025 D-loop; other site 767462000026 H-loop/switch region; other site 767462000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 767462000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767462000029 Mg2+ binding site [ion binding]; other site 767462000030 G-X-G motif; other site 767462000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 767462000032 anchoring element; other site 767462000033 dimer interface [polypeptide binding]; other site 767462000034 ATP binding site [chemical binding]; other site 767462000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 767462000036 active site 767462000037 putative metal-binding site [ion binding]; other site 767462000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 767462000039 DNA gyrase subunit A; Validated; Region: PRK05560 767462000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 767462000041 CAP-like domain; other site 767462000042 active site 767462000043 primary dimer interface [polypeptide binding]; other site 767462000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767462000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767462000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767462000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767462000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767462000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767462000050 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 767462000051 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 767462000052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 767462000053 dimer interface [polypeptide binding]; other site 767462000054 ssDNA binding site [nucleotide binding]; other site 767462000055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767462000056 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 767462000057 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767462000058 MULE transposase domain; Region: MULE; pfam10551 767462000059 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767462000060 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767462000061 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 767462000062 Walker A/P-loop; other site 767462000063 ATP binding site [chemical binding]; other site 767462000064 Q-loop/lid; other site 767462000065 ABC transporter signature motif; other site 767462000066 Walker B; other site 767462000067 D-loop; other site 767462000068 H-loop/switch region; other site 767462000069 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 767462000070 active site 767462000071 zinc binding site [ion binding]; other site 767462000072 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767462000073 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 767462000074 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 767462000075 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 767462000076 DHH family; Region: DHH; pfam01368 767462000077 DHHA1 domain; Region: DHHA1; pfam02272 767462000078 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 767462000079 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 767462000080 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 767462000081 replicative DNA helicase; Region: DnaB; TIGR00665 767462000082 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 767462000083 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 767462000084 Walker A motif; other site 767462000085 ATP binding site [chemical binding]; other site 767462000086 Walker B motif; other site 767462000087 DNA binding loops [nucleotide binding] 767462000088 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 767462000089 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767462000090 membrane-bound complex binding site; other site 767462000091 hinge residues; other site 767462000092 EDD domain protein, DegV family; Region: DegV; TIGR00762 767462000093 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767462000094 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 767462000095 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 767462000096 nucleotide binding site [chemical binding]; other site 767462000097 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767462000098 Integrase core domain; Region: rve; pfam00665 767462000099 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 767462000100 Predicted membrane protein [Function unknown]; Region: COG2261 767462000101 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 767462000102 MgtC family; Region: MgtC; pfam02308 767462000103 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 767462000104 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 767462000105 Replication initiation factor; Region: Rep_trans; pfam02486 767462000106 Helix-turn-helix domain; Region: HTH_17; pfam12728 767462000107 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767462000108 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 767462000109 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 767462000110 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767462000111 catalytic residue [active] 767462000112 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 767462000113 nucleotide binding site/active site [active] 767462000114 HIT family signature motif; other site 767462000115 catalytic residue [active] 767462000116 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 767462000117 metal binding site [ion binding]; metal-binding site 767462000118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462000119 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462000120 enolase; Provisional; Region: eno; PRK00077 767462000121 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 767462000122 dimer interface [polypeptide binding]; other site 767462000123 metal binding site [ion binding]; metal-binding site 767462000124 substrate binding pocket [chemical binding]; other site 767462000125 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 767462000126 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767462000127 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462000128 sequence-specific DNA binding site [nucleotide binding]; other site 767462000129 salt bridge; other site 767462000130 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 767462000131 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767462000132 Walker A/P-loop; other site 767462000133 ATP binding site [chemical binding]; other site 767462000134 Q-loop/lid; other site 767462000135 ABC transporter signature motif; other site 767462000136 Walker B; other site 767462000137 D-loop; other site 767462000138 H-loop/switch region; other site 767462000139 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 767462000140 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 767462000141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767462000142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767462000143 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 767462000144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767462000145 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 767462000146 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 767462000147 Predicted membrane protein [Function unknown]; Region: COG4905 767462000148 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 767462000149 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 767462000150 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 767462000151 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 767462000152 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 767462000153 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 767462000154 catalytic triad [active] 767462000155 oxyanion hole [active] 767462000156 active site 767462000157 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 767462000158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462000159 Walker A/P-loop; other site 767462000160 ATP binding site [chemical binding]; other site 767462000161 Q-loop/lid; other site 767462000162 ABC transporter signature motif; other site 767462000163 Walker B; other site 767462000164 D-loop; other site 767462000165 H-loop/switch region; other site 767462000166 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 767462000167 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 767462000168 TM-ABC transporter signature motif; other site 767462000169 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 767462000170 zinc binding site [ion binding]; other site 767462000171 putative ligand binding site [chemical binding]; other site 767462000172 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 767462000173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462000174 motif II; other site 767462000175 Bacterial surface layer protein; Region: SLAP; pfam03217 767462000176 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767462000177 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767462000178 active site 767462000179 catalytic tetrad [active] 767462000180 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 767462000181 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 767462000182 G1 box; other site 767462000183 putative GEF interaction site [polypeptide binding]; other site 767462000184 GTP/Mg2+ binding site [chemical binding]; other site 767462000185 Switch I region; other site 767462000186 G2 box; other site 767462000187 G3 box; other site 767462000188 Switch II region; other site 767462000189 G4 box; other site 767462000190 G5 box; other site 767462000191 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 767462000192 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 767462000193 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 767462000194 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462000195 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767462000196 active site 767462000197 motif I; other site 767462000198 motif II; other site 767462000199 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767462000200 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767462000201 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 767462000202 Walker A/P-loop; other site 767462000203 ATP binding site [chemical binding]; other site 767462000204 Q-loop/lid; other site 767462000205 ABC transporter signature motif; other site 767462000206 Walker B; other site 767462000207 D-loop; other site 767462000208 H-loop/switch region; other site 767462000209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462000210 non-specific DNA binding site [nucleotide binding]; other site 767462000211 salt bridge; other site 767462000212 sequence-specific DNA binding site [nucleotide binding]; other site 767462000213 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 767462000214 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 767462000215 homodimer interface [polypeptide binding]; other site 767462000216 ligand binding site [chemical binding]; other site 767462000217 NAD binding site [chemical binding]; other site 767462000218 catalytic site [active] 767462000219 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 767462000220 active site 767462000221 putative catalytic site [active] 767462000222 DNA binding site [nucleotide binding] 767462000223 putative phosphate binding site [ion binding]; other site 767462000224 metal binding site A [ion binding]; metal-binding site 767462000225 AP binding site [nucleotide binding]; other site 767462000226 metal binding site B [ion binding]; metal-binding site 767462000227 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 767462000228 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 767462000229 PLD-like domain; Region: PLDc_2; pfam13091 767462000230 putative homodimer interface [polypeptide binding]; other site 767462000231 putative active site [active] 767462000232 catalytic site [active] 767462000233 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 767462000234 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767462000235 ATP binding site [chemical binding]; other site 767462000236 putative Mg++ binding site [ion binding]; other site 767462000237 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767462000238 nucleotide binding region [chemical binding]; other site 767462000239 ATP-binding site [chemical binding]; other site 767462000240 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 767462000241 Beta-lactamase; Region: Beta-lactamase; pfam00144 767462000242 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767462000243 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 767462000244 active site 767462000245 catalytic residues [active] 767462000246 metal binding site [ion binding]; metal-binding site 767462000247 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767462000248 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767462000249 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 767462000250 dimerization interface [polypeptide binding]; other site 767462000251 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 767462000252 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 767462000253 putative acyl-acceptor binding pocket; other site 767462000254 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 767462000255 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 767462000256 Ligand binding site; other site 767462000257 metal-binding site 767462000258 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 767462000259 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 767462000260 Ligand binding site; other site 767462000261 metal-binding site 767462000262 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 767462000263 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 767462000264 active site 767462000265 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 767462000266 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 767462000267 putative acyl-acceptor binding pocket; other site 767462000268 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462000269 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462000270 Probable transposase; Region: OrfB_IS605; pfam01385 767462000271 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462000272 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462000273 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767462000274 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 767462000275 Integrase core domain; Region: rve; pfam00665 767462000276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462000277 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767462000278 Walker A/P-loop; other site 767462000279 ATP binding site [chemical binding]; other site 767462000280 Q-loop/lid; other site 767462000281 ABC transporter signature motif; other site 767462000282 Walker B; other site 767462000283 D-loop; other site 767462000284 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767462000285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767462000286 active site 767462000287 phosphorylation site [posttranslational modification] 767462000288 intermolecular recognition site; other site 767462000289 dimerization interface [polypeptide binding]; other site 767462000290 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767462000291 DNA binding site [nucleotide binding] 767462000292 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 767462000293 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767462000294 dimerization interface [polypeptide binding]; other site 767462000295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767462000296 putative active site [active] 767462000297 heme pocket [chemical binding]; other site 767462000298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767462000299 dimer interface [polypeptide binding]; other site 767462000300 phosphorylation site [posttranslational modification] 767462000301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767462000302 ATP binding site [chemical binding]; other site 767462000303 Mg2+ binding site [ion binding]; other site 767462000304 G-X-G motif; other site 767462000305 YycH protein; Region: YycH; pfam07435 767462000306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 767462000307 YycH protein; Region: YycI; pfam09648 767462000308 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 767462000309 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 767462000310 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 767462000311 protein binding site [polypeptide binding]; other site 767462000312 N-terminal sub-domain of the Rel homology domain (RHD); Region: RHD-n; cl08275 767462000313 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 767462000314 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767462000315 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462000316 Walker A/P-loop; other site 767462000317 ATP binding site [chemical binding]; other site 767462000318 Q-loop/lid; other site 767462000319 ABC transporter signature motif; other site 767462000320 Walker B; other site 767462000321 D-loop; other site 767462000322 H-loop/switch region; other site 767462000323 Bacterial surface layer protein; Region: SLAP; pfam03217 767462000324 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462000325 sequence-specific DNA binding site [nucleotide binding]; other site 767462000326 salt bridge; other site 767462000327 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 767462000328 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 767462000329 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767462000330 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767462000331 Walker A/P-loop; other site 767462000332 ATP binding site [chemical binding]; other site 767462000333 Q-loop/lid; other site 767462000334 ABC transporter signature motif; other site 767462000335 Walker B; other site 767462000336 D-loop; other site 767462000337 H-loop/switch region; other site 767462000338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462000339 Walker A/P-loop; other site 767462000340 ATP binding site [chemical binding]; other site 767462000341 ABC transporter; Region: ABC_tran; pfam00005 767462000342 Q-loop/lid; other site 767462000343 ABC transporter signature motif; other site 767462000344 Walker B; other site 767462000345 D-loop; other site 767462000346 H-loop/switch region; other site 767462000347 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 767462000348 Helix-turn-helix domain; Region: HTH_18; pfam12833 767462000349 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767462000350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767462000351 Transposase; Region: HTH_Tnp_1; cl17663 767462000352 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767462000353 Helix-turn-helix domain; Region: HTH_28; pfam13518 767462000354 Winged helix-turn helix; Region: HTH_29; pfam13551 767462000355 heat shock protein HtpX; Provisional; Region: PRK04897 767462000356 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 767462000357 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 767462000358 transmembrane helices; other site 767462000359 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 767462000360 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767462000361 Zn2+ binding site [ion binding]; other site 767462000362 Mg2+ binding site [ion binding]; other site 767462000363 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 767462000364 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 767462000365 active site 767462000366 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767462000367 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767462000368 Walker A/P-loop; other site 767462000369 ATP binding site [chemical binding]; other site 767462000370 Q-loop/lid; other site 767462000371 ABC transporter signature motif; other site 767462000372 Walker B; other site 767462000373 D-loop; other site 767462000374 H-loop/switch region; other site 767462000375 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767462000376 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767462000377 substrate binding pocket [chemical binding]; other site 767462000378 membrane-bound complex binding site; other site 767462000379 hinge residues; other site 767462000380 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 767462000381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462000382 dimer interface [polypeptide binding]; other site 767462000383 conserved gate region; other site 767462000384 putative PBP binding loops; other site 767462000385 ABC-ATPase subunit interface; other site 767462000386 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 767462000387 active site 767462000388 DNA binding site [nucleotide binding] 767462000389 Protein of unknown function, DUF488; Region: DUF488; cl01246 767462000390 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 767462000391 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 767462000392 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 767462000393 DNA binding site [nucleotide binding] 767462000394 active site 767462000395 NAD-dependent deacetylase; Provisional; Region: PRK00481 767462000396 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 767462000397 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 767462000398 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 767462000399 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 767462000400 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 767462000401 putative active site [active] 767462000402 catalytic site [active] 767462000403 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 767462000404 putative active site [active] 767462000405 catalytic site [active] 767462000406 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767462000407 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 767462000408 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 767462000409 RNA/DNA hybrid binding site [nucleotide binding]; other site 767462000410 active site 767462000411 Predicted secreted protein [Function unknown]; Region: COG4086 767462000412 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 767462000413 putative glycosyl transferase; Provisional; Region: PRK10073 767462000414 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767462000415 active site 767462000416 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 767462000417 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 767462000418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767462000419 NADH(P)-binding; Region: NAD_binding_10; pfam13460 767462000420 NAD(P) binding site [chemical binding]; other site 767462000421 active site 767462000422 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 767462000423 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 767462000424 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767462000425 active site 767462000426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767462000427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767462000428 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767462000429 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767462000430 substrate binding pocket [chemical binding]; other site 767462000431 membrane-bound complex binding site; other site 767462000432 hinge residues; other site 767462000433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462000434 dimer interface [polypeptide binding]; other site 767462000435 conserved gate region; other site 767462000436 putative PBP binding loops; other site 767462000437 ABC-ATPase subunit interface; other site 767462000438 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767462000439 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767462000440 Walker A/P-loop; other site 767462000441 ATP binding site [chemical binding]; other site 767462000442 Q-loop/lid; other site 767462000443 ABC transporter signature motif; other site 767462000444 Walker B; other site 767462000445 D-loop; other site 767462000446 H-loop/switch region; other site 767462000447 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 767462000448 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 767462000449 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 767462000450 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767462000451 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 767462000452 YibE/F-like protein; Region: YibE_F; pfam07907 767462000453 YibE/F-like protein; Region: YibE_F; pfam07907 767462000454 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 767462000455 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767462000456 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 767462000457 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 767462000458 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 767462000459 active site 767462000460 catalytic site [active] 767462000461 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 767462000462 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 767462000463 Interdomain contacts; other site 767462000464 Cytokine receptor motif; other site 767462000465 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 767462000466 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 767462000467 active site 767462000468 phosphorylation site [posttranslational modification] 767462000469 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 767462000470 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 767462000471 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767462000472 Ligand Binding Site [chemical binding]; other site 767462000473 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 767462000474 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767462000475 membrane-bound complex binding site; other site 767462000476 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 767462000477 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 767462000478 Walker A/P-loop; other site 767462000479 ATP binding site [chemical binding]; other site 767462000480 Q-loop/lid; other site 767462000481 ABC transporter signature motif; other site 767462000482 Walker B; other site 767462000483 D-loop; other site 767462000484 H-loop/switch region; other site 767462000485 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 767462000486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462000487 dimer interface [polypeptide binding]; other site 767462000488 conserved gate region; other site 767462000489 putative PBP binding loops; other site 767462000490 ABC-ATPase subunit interface; other site 767462000491 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 767462000492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462000493 dimer interface [polypeptide binding]; other site 767462000494 conserved gate region; other site 767462000495 putative PBP binding loops; other site 767462000496 ABC-ATPase subunit interface; other site 767462000497 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462000498 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462000499 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 767462000500 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 767462000501 active site 767462000502 metal binding site [ion binding]; metal-binding site 767462000503 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 767462000504 active site 767462000505 dimer interface [polypeptide binding]; other site 767462000506 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 767462000507 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 767462000508 Ligand Binding Site [chemical binding]; other site 767462000509 Molecular Tunnel; other site 767462000510 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 767462000511 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 767462000512 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767462000513 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 767462000514 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 767462000515 ATP cone domain; Region: ATP-cone; pfam03477 767462000516 Class III ribonucleotide reductase; Region: RNR_III; cd01675 767462000517 effector binding site; other site 767462000518 active site 767462000519 Zn binding site [ion binding]; other site 767462000520 glycine loop; other site 767462000521 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 767462000522 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 767462000523 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 767462000524 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 767462000525 Uncharacterized conserved protein [Function unknown]; Region: COG2461 767462000526 Family of unknown function (DUF438); Region: DUF438; pfam04282 767462000527 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 767462000528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767462000529 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767462000530 putative substrate translocation pore; other site 767462000531 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 767462000532 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 767462000533 active site 767462000534 Zn binding site [ion binding]; other site 767462000535 K+ potassium transporter; Region: K_trans; pfam02705 767462000536 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 767462000537 Bacterial surface layer protein; Region: SLAP; pfam03217 767462000538 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 767462000539 Bacterial surface layer protein; Region: SLAP; pfam03217 767462000540 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 767462000541 amidase catalytic site [active] 767462000542 Zn binding residues [ion binding]; other site 767462000543 substrate binding site [chemical binding]; other site 767462000544 Bacterial surface layer protein; Region: SLAP; pfam03217 767462000545 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 767462000546 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 767462000547 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 767462000548 TrkA-N domain; Region: TrkA_N; pfam02254 767462000549 TrkA-C domain; Region: TrkA_C; pfam02080 767462000550 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 767462000551 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 767462000552 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767462000553 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 767462000554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462000555 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462000556 Probable transposase; Region: OrfB_IS605; pfam01385 767462000557 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462000558 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462000559 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767462000560 catalytic core [active] 767462000561 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767462000562 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 767462000563 putative substrate binding pocket [chemical binding]; other site 767462000564 AC domain interface; other site 767462000565 catalytic triad [active] 767462000566 AB domain interface; other site 767462000567 interchain disulfide; other site 767462000568 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 767462000569 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 767462000570 membrane protein; Provisional; Region: PRK14411 767462000571 Sulfatase; Region: Sulfatase; cl17466 767462000572 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 767462000573 Interdomain contacts; other site 767462000574 Cytokine receptor motif; other site 767462000575 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 767462000576 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 767462000577 active site 767462000578 HIGH motif; other site 767462000579 dimer interface [polypeptide binding]; other site 767462000580 KMSKS motif; other site 767462000581 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767462000582 RNA binding surface [nucleotide binding]; other site 767462000583 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 767462000584 trimer interface [polypeptide binding]; other site 767462000585 active site 767462000586 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 767462000587 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 767462000588 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 767462000589 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 767462000590 active site 767462000591 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 767462000592 trimer interface [polypeptide binding]; other site 767462000593 active site 767462000594 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 767462000595 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 767462000596 putative dimer interface [polypeptide binding]; other site 767462000597 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 767462000598 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 767462000599 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 767462000600 CAAX protease self-immunity; Region: Abi; pfam02517 767462000601 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 767462000602 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 767462000603 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 767462000604 active site 767462000605 HIGH motif; other site 767462000606 dimer interface [polypeptide binding]; other site 767462000607 KMSKS motif; other site 767462000608 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 767462000609 catalytic motif [active] 767462000610 Zn binding site [ion binding]; other site 767462000611 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 767462000612 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 767462000613 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767462000614 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 767462000615 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767462000616 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 767462000617 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 767462000618 active site 767462000619 HIGH motif; other site 767462000620 KMSKS motif; other site 767462000621 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 767462000622 tRNA binding surface [nucleotide binding]; other site 767462000623 anticodon binding site; other site 767462000624 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 767462000625 dimer interface [polypeptide binding]; other site 767462000626 putative tRNA-binding site [nucleotide binding]; other site 767462000627 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 767462000628 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 767462000629 active site 767462000630 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 767462000631 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 767462000632 putative active site [active] 767462000633 putative metal binding site [ion binding]; other site 767462000634 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 767462000635 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 767462000636 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 767462000637 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 767462000638 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 767462000639 pur operon repressor; Provisional; Region: PRK09213 767462000640 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 767462000641 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767462000642 active site 767462000643 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 767462000644 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 767462000645 Substrate binding site; other site 767462000646 Mg++ binding site; other site 767462000647 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 767462000648 active site 767462000649 substrate binding site [chemical binding]; other site 767462000650 CoA binding site [chemical binding]; other site 767462000651 Bacterial surface layer protein; Region: SLAP; pfam03217 767462000652 Bacterial surface layer protein; Region: SLAP; pfam03217 767462000653 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462000654 Probable transposase; Region: OrfB_IS605; pfam01385 767462000655 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462000656 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767462000657 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462000658 Bacterial surface layer protein; Region: SLAP; pfam03217 767462000659 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 767462000660 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 767462000661 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767462000662 active site 767462000663 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 767462000664 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 767462000665 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 767462000666 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767462000667 Zn2+ binding site [ion binding]; other site 767462000668 Mg2+ binding site [ion binding]; other site 767462000669 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 767462000670 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 767462000671 CTP synthetase; Validated; Region: pyrG; PRK05380 767462000672 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 767462000673 active site 767462000674 UTP binding site [chemical binding]; other site 767462000675 Catalytic site [active] 767462000676 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 767462000677 active site 767462000678 putative oxyanion hole; other site 767462000679 catalytic triad [active] 767462000680 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 767462000681 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 767462000682 hinge; other site 767462000683 active site 767462000684 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 767462000685 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767462000686 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462000687 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 767462000688 motif II; other site 767462000689 Peptidase family C69; Region: Peptidase_C69; pfam03577 767462000690 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 767462000691 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 767462000692 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767462000693 xanthine permease; Region: pbuX; TIGR03173 767462000694 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767462000695 active site 767462000696 GMP synthase; Reviewed; Region: guaA; PRK00074 767462000697 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 767462000698 AMP/PPi binding site [chemical binding]; other site 767462000699 candidate oxyanion hole; other site 767462000700 catalytic triad [active] 767462000701 potential glutamine specificity residues [chemical binding]; other site 767462000702 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 767462000703 ATP Binding subdomain [chemical binding]; other site 767462000704 Ligand Binding sites [chemical binding]; other site 767462000705 Dimerization subdomain; other site 767462000706 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767462000707 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 767462000708 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 767462000709 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 767462000710 dimer interface [polypeptide binding]; other site 767462000711 active site 767462000712 glycine-pyridoxal phosphate binding site [chemical binding]; other site 767462000713 folate binding site [chemical binding]; other site 767462000714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462000715 non-specific DNA binding site [nucleotide binding]; other site 767462000716 salt bridge; other site 767462000717 sequence-specific DNA binding site [nucleotide binding]; other site 767462000718 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 767462000719 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767462000720 MULE transposase domain; Region: MULE; pfam10551 767462000721 Bacterial surface layer protein; Region: SLAP; pfam03217 767462000722 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462000723 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462000724 Probable transposase; Region: OrfB_IS605; pfam01385 767462000725 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462000726 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462000727 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767462000728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462000729 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 767462000730 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 767462000731 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767462000732 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767462000733 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 767462000734 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767462000735 ATP binding site [chemical binding]; other site 767462000736 Mg++ binding site [ion binding]; other site 767462000737 motif III; other site 767462000738 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767462000739 nucleotide binding region [chemical binding]; other site 767462000740 ATP-binding site [chemical binding]; other site 767462000741 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 767462000742 alanine racemase; Reviewed; Region: alr; PRK00053 767462000743 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 767462000744 active site 767462000745 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 767462000746 dimer interface [polypeptide binding]; other site 767462000747 substrate binding site [chemical binding]; other site 767462000748 catalytic residues [active] 767462000749 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767462000750 FOG: CBS domain [General function prediction only]; Region: COG0517 767462000751 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 767462000752 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 767462000753 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 767462000754 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767462000755 NAD binding site [chemical binding]; other site 767462000756 dimer interface [polypeptide binding]; other site 767462000757 substrate binding site [chemical binding]; other site 767462000758 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 767462000759 putative active site [active] 767462000760 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 767462000761 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 767462000762 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767462000763 ATP binding site [chemical binding]; other site 767462000764 putative Mg++ binding site [ion binding]; other site 767462000765 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767462000766 nucleotide binding region [chemical binding]; other site 767462000767 ATP-binding site [chemical binding]; other site 767462000768 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 767462000769 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767462000770 RNA binding surface [nucleotide binding]; other site 767462000771 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 767462000772 Septum formation initiator; Region: DivIC; pfam04977 767462000773 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 767462000774 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 767462000775 RNA binding site [nucleotide binding]; other site 767462000776 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 767462000777 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 767462000778 Ligand Binding Site [chemical binding]; other site 767462000779 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 767462000780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767462000781 Walker A motif; other site 767462000782 ATP binding site [chemical binding]; other site 767462000783 Walker B motif; other site 767462000784 arginine finger; other site 767462000785 Peptidase family M41; Region: Peptidase_M41; pfam01434 767462000786 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 767462000787 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 767462000788 dimerization interface [polypeptide binding]; other site 767462000789 domain crossover interface; other site 767462000790 redox-dependent activation switch; other site 767462000791 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 767462000792 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 767462000793 FMN binding site [chemical binding]; other site 767462000794 active site 767462000795 catalytic residues [active] 767462000796 substrate binding site [chemical binding]; other site 767462000797 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 767462000798 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 767462000799 dimer interface [polypeptide binding]; other site 767462000800 putative anticodon binding site; other site 767462000801 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 767462000802 motif 1; other site 767462000803 active site 767462000804 motif 2; other site 767462000805 motif 3; other site 767462000806 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 767462000807 GAF domain; Region: GAF_2; pfam13185 767462000808 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 767462000809 Clp amino terminal domain; Region: Clp_N; pfam02861 767462000810 Clp amino terminal domain; Region: Clp_N; pfam02861 767462000811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767462000812 Walker A motif; other site 767462000813 ATP binding site [chemical binding]; other site 767462000814 Walker B motif; other site 767462000815 arginine finger; other site 767462000816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767462000817 Walker A motif; other site 767462000818 ATP binding site [chemical binding]; other site 767462000819 Walker B motif; other site 767462000820 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 767462000821 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 767462000822 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 767462000823 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 767462000824 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 767462000825 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 767462000826 RPB1 interaction site [polypeptide binding]; other site 767462000827 RPB10 interaction site [polypeptide binding]; other site 767462000828 RPB11 interaction site [polypeptide binding]; other site 767462000829 RPB3 interaction site [polypeptide binding]; other site 767462000830 RPB12 interaction site [polypeptide binding]; other site 767462000831 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 767462000832 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 767462000833 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 767462000834 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 767462000835 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 767462000836 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 767462000837 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 767462000838 G-loop; other site 767462000839 DNA binding site [nucleotide binding] 767462000840 putative transposase OrfB; Reviewed; Region: PHA02517 767462000841 HTH-like domain; Region: HTH_21; pfam13276 767462000842 Integrase core domain; Region: rve; pfam00665 767462000843 Integrase core domain; Region: rve_2; pfam13333 767462000844 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 767462000845 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 767462000846 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 767462000847 S17 interaction site [polypeptide binding]; other site 767462000848 S8 interaction site; other site 767462000849 16S rRNA interaction site [nucleotide binding]; other site 767462000850 streptomycin interaction site [chemical binding]; other site 767462000851 23S rRNA interaction site [nucleotide binding]; other site 767462000852 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 767462000853 30S ribosomal protein S7; Validated; Region: PRK05302 767462000854 elongation factor G; Reviewed; Region: PRK12739 767462000855 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 767462000856 G1 box; other site 767462000857 putative GEF interaction site [polypeptide binding]; other site 767462000858 GTP/Mg2+ binding site [chemical binding]; other site 767462000859 Switch I region; other site 767462000860 G2 box; other site 767462000861 G3 box; other site 767462000862 Switch II region; other site 767462000863 G4 box; other site 767462000864 G5 box; other site 767462000865 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 767462000866 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 767462000867 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 767462000868 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767462000869 HTH-like domain; Region: HTH_21; pfam13276 767462000870 Integrase core domain; Region: rve; pfam00665 767462000871 Integrase core domain; Region: rve_2; pfam13333 767462000872 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 767462000873 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 767462000874 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 767462000875 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 767462000876 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 767462000877 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 767462000878 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 767462000879 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 767462000880 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 767462000881 protein-rRNA interface [nucleotide binding]; other site 767462000882 putative translocon binding site; other site 767462000883 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 767462000884 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 767462000885 G-X-X-G motif; other site 767462000886 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 767462000887 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 767462000888 23S rRNA interface [nucleotide binding]; other site 767462000889 5S rRNA interface [nucleotide binding]; other site 767462000890 putative antibiotic binding site [chemical binding]; other site 767462000891 L25 interface [polypeptide binding]; other site 767462000892 L27 interface [polypeptide binding]; other site 767462000893 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 767462000894 23S rRNA interface [nucleotide binding]; other site 767462000895 putative translocon interaction site; other site 767462000896 signal recognition particle (SRP54) interaction site; other site 767462000897 L23 interface [polypeptide binding]; other site 767462000898 trigger factor interaction site; other site 767462000899 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 767462000900 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 767462000901 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 767462000902 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 767462000903 RNA binding site [nucleotide binding]; other site 767462000904 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 767462000905 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 767462000906 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 767462000907 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 767462000908 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 767462000909 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 767462000910 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 767462000911 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 767462000912 23S rRNA interface [nucleotide binding]; other site 767462000913 L21e interface [polypeptide binding]; other site 767462000914 5S rRNA interface [nucleotide binding]; other site 767462000915 L27 interface [polypeptide binding]; other site 767462000916 L5 interface [polypeptide binding]; other site 767462000917 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 767462000918 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 767462000919 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 767462000920 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 767462000921 23S rRNA binding site [nucleotide binding]; other site 767462000922 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 767462000923 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 767462000924 SecY translocase; Region: SecY; pfam00344 767462000925 adenylate kinase; Reviewed; Region: adk; PRK00279 767462000926 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 767462000927 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 767462000928 AMP-binding site [chemical binding]; other site 767462000929 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 767462000930 rRNA binding site [nucleotide binding]; other site 767462000931 predicted 30S ribosome binding site; other site 767462000932 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 767462000933 30S ribosomal protein S13; Region: bact_S13; TIGR03631 767462000934 30S ribosomal protein S11; Validated; Region: PRK05309 767462000935 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 767462000936 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 767462000937 alphaNTD homodimer interface [polypeptide binding]; other site 767462000938 alphaNTD - beta interaction site [polypeptide binding]; other site 767462000939 alphaNTD - beta' interaction site [polypeptide binding]; other site 767462000940 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 767462000941 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 767462000942 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13640 767462000943 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767462000944 Walker A/P-loop; other site 767462000945 ATP binding site [chemical binding]; other site 767462000946 Q-loop/lid; other site 767462000947 ABC transporter signature motif; other site 767462000948 Walker B; other site 767462000949 D-loop; other site 767462000950 H-loop/switch region; other site 767462000951 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13641 767462000952 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767462000953 Walker A/P-loop; other site 767462000954 ATP binding site [chemical binding]; other site 767462000955 Q-loop/lid; other site 767462000956 ABC transporter signature motif; other site 767462000957 Walker B; other site 767462000958 D-loop; other site 767462000959 H-loop/switch region; other site 767462000960 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 767462000961 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 767462000962 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 767462000963 dimerization interface 3.5A [polypeptide binding]; other site 767462000964 active site 767462000965 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 767462000966 23S rRNA interface [nucleotide binding]; other site 767462000967 L3 interface [polypeptide binding]; other site 767462000968 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 767462000969 Protein of unknown function (DUF805); Region: DUF805; pfam05656 767462000970 DJ-1 family protein; Region: not_thiJ; TIGR01383 767462000971 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 767462000972 conserved cys residue [active] 767462000973 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 767462000974 hypothetical protein; Provisional; Region: PRK10621 767462000975 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 767462000976 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767462000977 catalytic core [active] 767462000978 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 767462000979 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 767462000980 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767462000981 catalytic core [active] 767462000982 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767462000983 AAA domain; Region: AAA_33; pfam13671 767462000984 magnesium-transporting ATPase; Provisional; Region: PRK15122 767462000985 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 767462000986 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767462000987 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 767462000988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462000989 motif II; other site 767462000990 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 767462000991 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 767462000992 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 767462000993 trimer interface [polypeptide binding]; other site 767462000994 active site 767462000995 G bulge; other site 767462000996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767462000997 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767462000998 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462000999 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462001000 Probable transposase; Region: OrfB_IS605; pfam01385 767462001001 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462001002 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462001003 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 767462001004 trimer interface [polypeptide binding]; other site 767462001005 active site 767462001006 DNA repair protein RadA; Provisional; Region: PRK11823 767462001007 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 767462001008 Walker A motif/ATP binding site; other site 767462001009 ATP binding site [chemical binding]; other site 767462001010 Walker B motif; other site 767462001011 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 767462001012 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 767462001013 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 767462001014 active site 767462001015 HIGH motif; other site 767462001016 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 767462001017 active site 767462001018 KMSKS motif; other site 767462001019 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 767462001020 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 767462001021 active site 767462001022 HIGH motif; other site 767462001023 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 767462001024 KMSKS motif; other site 767462001025 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 767462001026 tRNA binding surface [nucleotide binding]; other site 767462001027 anticodon binding site; other site 767462001028 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 767462001029 active site 767462001030 metal binding site [ion binding]; metal-binding site 767462001031 dimerization interface [polypeptide binding]; other site 767462001032 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 767462001033 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 767462001034 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 767462001035 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767462001036 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 767462001037 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 767462001038 N- and C-terminal domain interface [polypeptide binding]; other site 767462001039 active site 767462001040 catalytic site [active] 767462001041 metal binding site [ion binding]; metal-binding site 767462001042 carbohydrate binding site [chemical binding]; other site 767462001043 ATP binding site [chemical binding]; other site 767462001044 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 767462001045 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 767462001046 TPP-binding site; other site 767462001047 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 767462001048 PYR/PP interface [polypeptide binding]; other site 767462001049 dimer interface [polypeptide binding]; other site 767462001050 TPP binding site [chemical binding]; other site 767462001051 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767462001052 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 767462001053 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 767462001054 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 767462001055 putative homodimer interface [polypeptide binding]; other site 767462001056 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 767462001057 heterodimer interface [polypeptide binding]; other site 767462001058 homodimer interface [polypeptide binding]; other site 767462001059 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 767462001060 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 767462001061 23S rRNA interface [nucleotide binding]; other site 767462001062 L7/L12 interface [polypeptide binding]; other site 767462001063 putative thiostrepton binding site; other site 767462001064 L25 interface [polypeptide binding]; other site 767462001065 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 767462001066 mRNA/rRNA interface [nucleotide binding]; other site 767462001067 PBP superfamily domain; Region: PBP_like_2; cl17296 767462001068 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 767462001069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462001070 dimer interface [polypeptide binding]; other site 767462001071 conserved gate region; other site 767462001072 putative PBP binding loops; other site 767462001073 ABC-ATPase subunit interface; other site 767462001074 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 767462001075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462001076 dimer interface [polypeptide binding]; other site 767462001077 conserved gate region; other site 767462001078 putative PBP binding loops; other site 767462001079 ABC-ATPase subunit interface; other site 767462001080 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 767462001081 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 767462001082 Walker A/P-loop; other site 767462001083 ATP binding site [chemical binding]; other site 767462001084 Q-loop/lid; other site 767462001085 ABC transporter signature motif; other site 767462001086 Walker B; other site 767462001087 D-loop; other site 767462001088 H-loop/switch region; other site 767462001089 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14251 767462001090 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 767462001091 Walker A/P-loop; other site 767462001092 ATP binding site [chemical binding]; other site 767462001093 Q-loop/lid; other site 767462001094 ABC transporter signature motif; other site 767462001095 Walker B; other site 767462001096 D-loop; other site 767462001097 H-loop/switch region; other site 767462001098 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 767462001099 PhoU domain; Region: PhoU; pfam01895 767462001100 PhoU domain; Region: PhoU; pfam01895 767462001101 Membrane transport protein; Region: Mem_trans; cl09117 767462001102 Membrane transport protein; Region: Mem_trans; cl09117 767462001103 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 767462001104 23S rRNA interface [nucleotide binding]; other site 767462001105 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 767462001106 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 767462001107 L11 interface [polypeptide binding]; other site 767462001108 putative EF-Tu interaction site [polypeptide binding]; other site 767462001109 putative EF-G interaction site [polypeptide binding]; other site 767462001110 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 767462001111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767462001112 S-adenosylmethionine binding site [chemical binding]; other site 767462001113 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 767462001114 nucleoside/Zn binding site; other site 767462001115 dimer interface [polypeptide binding]; other site 767462001116 catalytic motif [active] 767462001117 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 767462001118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767462001119 Walker A motif; other site 767462001120 ATP binding site [chemical binding]; other site 767462001121 Walker B motif; other site 767462001122 hypothetical protein; Validated; Region: PRK00153 767462001123 recombination protein RecR; Reviewed; Region: recR; PRK00076 767462001124 RecR protein; Region: RecR; pfam02132 767462001125 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 767462001126 putative active site [active] 767462001127 putative metal-binding site [ion binding]; other site 767462001128 tetramer interface [polypeptide binding]; other site 767462001129 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 767462001130 thymidylate kinase; Validated; Region: tmk; PRK00698 767462001131 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 767462001132 TMP-binding site; other site 767462001133 ATP-binding site [chemical binding]; other site 767462001134 Protein of unknown function (DUF970); Region: DUF970; cl17525 767462001135 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 767462001136 DNA polymerase III subunit delta'; Validated; Region: PRK08485 767462001137 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 767462001138 Predicted methyltransferases [General function prediction only]; Region: COG0313 767462001139 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 767462001140 putative SAM binding site [chemical binding]; other site 767462001141 putative homodimer interface [polypeptide binding]; other site 767462001142 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 767462001143 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 767462001144 active site 767462001145 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 767462001146 active site 2 [active] 767462001147 active site 1 [active] 767462001148 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 767462001149 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 767462001150 Glycoprotease family; Region: Peptidase_M22; pfam00814 767462001151 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 767462001152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767462001153 Coenzyme A binding pocket [chemical binding]; other site 767462001154 UGMP family protein; Validated; Region: PRK09604 767462001155 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 767462001156 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 767462001157 intersubunit interface [polypeptide binding]; other site 767462001158 active site 767462001159 catalytic residue [active] 767462001160 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 767462001161 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767462001162 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 767462001163 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767462001164 DNA-binding site [nucleotide binding]; DNA binding site 767462001165 UTRA domain; Region: UTRA; pfam07702 767462001166 Toxin ToxN, type III toxin-antitoxin system; Region: ToxN_toxin; pfam13958 767462001167 T-complex protein 11; Region: Tcp11; pfam05794 767462001168 CoA-transferase family III; Region: CoA_transf_3; pfam02515 767462001169 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 767462001170 PYR/PP interface [polypeptide binding]; other site 767462001171 dimer interface [polypeptide binding]; other site 767462001172 TPP binding site [chemical binding]; other site 767462001173 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 767462001174 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 767462001175 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 767462001176 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767462001177 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767462001178 ABC transporter; Region: ABC_tran_2; pfam12848 767462001179 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767462001180 ABC transporter; Region: ABC_tran_2; pfam12848 767462001181 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 767462001182 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 767462001183 CoA binding domain; Region: CoA_binding; pfam02629 767462001184 LytTr DNA-binding domain; Region: LytTR; smart00850 767462001185 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767462001186 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767462001187 DNA binding site [nucleotide binding] 767462001188 domain linker motif; other site 767462001189 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 767462001190 dimerization interface [polypeptide binding]; other site 767462001191 ligand binding site [chemical binding]; other site 767462001192 sodium binding site [ion binding]; other site 767462001193 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 767462001194 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 767462001195 substrate binding [chemical binding]; other site 767462001196 active site 767462001197 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 767462001198 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 767462001199 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767462001200 active site turn [active] 767462001201 phosphorylation site [posttranslational modification] 767462001202 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767462001203 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 767462001204 HPr interaction site; other site 767462001205 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767462001206 active site 767462001207 phosphorylation site [posttranslational modification] 767462001208 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 767462001209 oligomerisation interface [polypeptide binding]; other site 767462001210 mobile loop; other site 767462001211 roof hairpin; other site 767462001212 chaperonin GroL; Region: GroEL; TIGR02348 767462001213 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 767462001214 ring oligomerisation interface [polypeptide binding]; other site 767462001215 ATP/Mg binding site [chemical binding]; other site 767462001216 stacking interactions; other site 767462001217 hinge regions; other site 767462001218 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 767462001219 MutS domain I; Region: MutS_I; pfam01624 767462001220 MutS domain II; Region: MutS_II; pfam05188 767462001221 MutS domain III; Region: MutS_III; pfam05192 767462001222 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 767462001223 Walker A/P-loop; other site 767462001224 ATP binding site [chemical binding]; other site 767462001225 Q-loop/lid; other site 767462001226 ABC transporter signature motif; other site 767462001227 Walker B; other site 767462001228 D-loop; other site 767462001229 H-loop/switch region; other site 767462001230 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 767462001231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767462001232 ATP binding site [chemical binding]; other site 767462001233 Mg2+ binding site [ion binding]; other site 767462001234 G-X-G motif; other site 767462001235 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 767462001236 ATP binding site [chemical binding]; other site 767462001237 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 767462001238 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 767462001239 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 767462001240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767462001241 Walker A motif; other site 767462001242 ATP binding site [chemical binding]; other site 767462001243 Walker B motif; other site 767462001244 arginine finger; other site 767462001245 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 767462001246 Preprotein translocase subunit; Region: YajC; pfam02699 767462001247 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 767462001248 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 767462001249 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 767462001250 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 767462001251 DHH family; Region: DHH; pfam01368 767462001252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767462001253 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767462001254 ATP binding site [chemical binding]; other site 767462001255 putative Mg++ binding site [ion binding]; other site 767462001256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767462001257 nucleotide binding region [chemical binding]; other site 767462001258 ATP-binding site [chemical binding]; other site 767462001259 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 767462001260 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 767462001261 motif 1; other site 767462001262 active site 767462001263 motif 2; other site 767462001264 motif 3; other site 767462001265 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 767462001266 DHHA1 domain; Region: DHHA1; pfam02272 767462001267 hypothetical protein; Provisional; Region: PRK05473 767462001268 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 767462001269 hypothetical protein; Provisional; Region: PRK13678 767462001270 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 767462001271 MutS domain III; Region: MutS_III; pfam05192 767462001272 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 767462001273 Walker A/P-loop; other site 767462001274 ATP binding site [chemical binding]; other site 767462001275 Q-loop/lid; other site 767462001276 ABC transporter signature motif; other site 767462001277 Walker B; other site 767462001278 D-loop; other site 767462001279 H-loop/switch region; other site 767462001280 Smr domain; Region: Smr; pfam01713 767462001281 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 767462001282 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 767462001283 catalytic residues [active] 767462001284 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 767462001285 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 767462001286 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 767462001287 glutamate racemase; Provisional; Region: PRK00865 767462001288 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 767462001289 active site 767462001290 dimerization interface [polypeptide binding]; other site 767462001291 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 767462001292 Mechanosensitive ion channel; Region: MS_channel; pfam00924 767462001293 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 767462001294 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 767462001295 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 767462001296 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 767462001297 active site 767462001298 catabolite control protein A; Region: ccpA; TIGR01481 767462001299 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767462001300 DNA binding site [nucleotide binding] 767462001301 domain linker motif; other site 767462001302 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 767462001303 dimerization interface [polypeptide binding]; other site 767462001304 effector binding site; other site 767462001305 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 767462001306 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 767462001307 active site 767462001308 catalytic site [active] 767462001309 metal binding site [ion binding]; metal-binding site 767462001310 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 767462001311 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 767462001312 active site 767462001313 metal binding site [ion binding]; metal-binding site 767462001314 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 767462001315 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 767462001316 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 767462001317 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462001318 active site 767462001319 motif I; other site 767462001320 motif II; other site 767462001321 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462001322 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 767462001323 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 767462001324 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 767462001325 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 767462001326 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767462001327 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767462001328 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 767462001329 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767462001330 putative ADP-binding pocket [chemical binding]; other site 767462001331 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767462001332 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 767462001333 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 767462001334 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 767462001335 Sulfatase; Region: Sulfatase; pfam00884 767462001336 Preprotein translocase SecG subunit; Region: SecG; cl09123 767462001337 ribonuclease R; Region: RNase_R; TIGR02063 767462001338 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 767462001339 RNB domain; Region: RNB; pfam00773 767462001340 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 767462001341 RNA binding site [nucleotide binding]; other site 767462001342 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 767462001343 SmpB-tmRNA interface; other site 767462001344 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 767462001345 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 767462001346 intersubunit interface [polypeptide binding]; other site 767462001347 S-adenosylmethionine synthetase; Validated; Region: PRK05250 767462001348 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 767462001349 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 767462001350 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 767462001351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767462001352 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767462001353 putative substrate translocation pore; other site 767462001354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767462001355 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 767462001356 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 767462001357 substrate binding pocket [chemical binding]; other site 767462001358 chain length determination region; other site 767462001359 substrate-Mg2+ binding site; other site 767462001360 catalytic residues [active] 767462001361 aspartate-rich region 1; other site 767462001362 active site lid residues [active] 767462001363 aspartate-rich region 2; other site 767462001364 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 767462001365 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 767462001366 active site 767462001367 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 767462001368 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 767462001369 HIGH motif; other site 767462001370 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 767462001371 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 767462001372 active site 767462001373 KMSKS motif; other site 767462001374 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 767462001375 tRNA binding surface [nucleotide binding]; other site 767462001376 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 767462001377 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 767462001378 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 767462001379 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 767462001380 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 767462001381 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 767462001382 Bacterial surface layer protein; Region: SLAP; pfam03217 767462001383 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 767462001384 MucBP domain; Region: MucBP; pfam06458 767462001385 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 767462001386 catalytic residues [active] 767462001387 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767462001388 dimerization interface [polypeptide binding]; other site 767462001389 putative DNA binding site [nucleotide binding]; other site 767462001390 putative Zn2+ binding site [ion binding]; other site 767462001391 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 767462001392 active site residue [active] 767462001393 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 767462001394 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767462001395 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767462001396 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 767462001397 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 767462001398 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 767462001399 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767462001400 DNA-binding site [nucleotide binding]; DNA binding site 767462001401 UTRA domain; Region: UTRA; pfam07702 767462001402 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 767462001403 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 767462001404 Ca binding site [ion binding]; other site 767462001405 active site 767462001406 catalytic site [active] 767462001407 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 767462001408 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 767462001409 HPr interaction site; other site 767462001410 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767462001411 active site 767462001412 phosphorylation site [posttranslational modification] 767462001413 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 767462001414 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767462001415 active site turn [active] 767462001416 phosphorylation site [posttranslational modification] 767462001417 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767462001418 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 767462001419 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 767462001420 TPP-binding site [chemical binding]; other site 767462001421 Competence-damaged protein; Region: CinA; pfam02464 767462001422 DNA polymerase IV; Reviewed; Region: PRK03103 767462001423 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 767462001424 active site 767462001425 DNA binding site [nucleotide binding] 767462001426 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 767462001427 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462001428 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462001429 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 767462001430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767462001431 Coenzyme A binding pocket [chemical binding]; other site 767462001432 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 767462001433 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767462001434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462001435 motif II; other site 767462001436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767462001437 putative substrate translocation pore; other site 767462001438 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 767462001439 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 767462001440 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 767462001441 sugar phosphate phosphatase; Provisional; Region: PRK10513 767462001442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462001443 active site 767462001444 motif I; other site 767462001445 motif II; other site 767462001446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462001447 Enterocin A Immunity; Region: EntA_Immun; pfam08951 767462001448 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 767462001449 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 767462001450 PspC domain; Region: PspC; pfam04024 767462001451 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 767462001452 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 767462001453 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 767462001454 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 767462001455 putative substrate binding site [chemical binding]; other site 767462001456 putative ATP binding site [chemical binding]; other site 767462001457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 767462001458 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 767462001459 Predicted transcriptional regulators [Transcription]; Region: COG1695 767462001460 Transcriptional regulator PadR-like family; Region: PadR; cl17335 767462001461 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 767462001462 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 767462001463 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 767462001464 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 767462001465 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 767462001466 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 767462001467 active site 767462001468 HIGH motif; other site 767462001469 KMSK motif region; other site 767462001470 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 767462001471 tRNA binding surface [nucleotide binding]; other site 767462001472 anticodon binding site; other site 767462001473 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 767462001474 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 767462001475 intersubunit interface [polypeptide binding]; other site 767462001476 active site 767462001477 zinc binding site [ion binding]; other site 767462001478 Na+ binding site [ion binding]; other site 767462001479 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 767462001480 nudix motif; other site 767462001481 WbqC-like protein family; Region: WbqC; pfam08889 767462001482 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 767462001483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462001484 Walker A/P-loop; other site 767462001485 ATP binding site [chemical binding]; other site 767462001486 Q-loop/lid; other site 767462001487 ABC transporter signature motif; other site 767462001488 Walker B; other site 767462001489 D-loop; other site 767462001490 H-loop/switch region; other site 767462001491 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 767462001492 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 767462001493 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767462001494 MULE transposase domain; Region: MULE; pfam10551 767462001495 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767462001496 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767462001497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462001498 Walker A/P-loop; other site 767462001499 ATP binding site [chemical binding]; other site 767462001500 Q-loop/lid; other site 767462001501 ABC transporter signature motif; other site 767462001502 Walker B; other site 767462001503 D-loop; other site 767462001504 H-loop/switch region; other site 767462001505 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767462001506 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 767462001507 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767462001508 Walker A/P-loop; other site 767462001509 ATP binding site [chemical binding]; other site 767462001510 Q-loop/lid; other site 767462001511 ABC transporter signature motif; other site 767462001512 Walker B; other site 767462001513 D-loop; other site 767462001514 H-loop/switch region; other site 767462001515 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462001516 salt bridge; other site 767462001517 non-specific DNA binding site [nucleotide binding]; other site 767462001518 sequence-specific DNA binding site [nucleotide binding]; other site 767462001519 PemK-like protein; Region: PemK; pfam02452 767462001520 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462001521 Probable transposase; Region: OrfB_IS605; pfam01385 767462001522 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462001523 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 767462001524 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 767462001525 EDD domain protein, DegV family; Region: DegV; TIGR00762 767462001526 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767462001527 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 767462001528 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 767462001529 amphipathic channel; other site 767462001530 Asn-Pro-Ala signature motifs; other site 767462001531 MgtC family; Region: MgtC; pfam02308 767462001532 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767462001533 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767462001534 active site 767462001535 Transglycosylase; Region: Transgly; pfam00912 767462001536 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 767462001537 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767462001538 hypothetical protein; Provisional; Region: PRK13676 767462001539 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 767462001540 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 767462001541 active site 767462001542 metal binding site [ion binding]; metal-binding site 767462001543 DNA binding site [nucleotide binding] 767462001544 P-loop containing region of AAA domain; Region: AAA_29; cl17516 767462001545 AAA domain; Region: AAA_23; pfam13476 767462001546 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 767462001547 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 767462001548 generic binding surface I; other site 767462001549 generic binding surface II; other site 767462001550 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767462001551 Zn2+ binding site [ion binding]; other site 767462001552 Mg2+ binding site [ion binding]; other site 767462001553 Uncharacterized conserved protein [Function unknown]; Region: COG2461 767462001554 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 767462001555 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462001556 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 767462001557 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 767462001558 YtxH-like protein; Region: YtxH; cl02079 767462001559 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 767462001560 HIT family signature motif; other site 767462001561 catalytic residue [active] 767462001562 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462001563 non-specific DNA binding site [nucleotide binding]; other site 767462001564 salt bridge; other site 767462001565 sequence-specific DNA binding site [nucleotide binding]; other site 767462001566 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767462001567 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767462001568 Walker A/P-loop; other site 767462001569 ATP binding site [chemical binding]; other site 767462001570 Q-loop/lid; other site 767462001571 ABC transporter signature motif; other site 767462001572 Walker B; other site 767462001573 D-loop; other site 767462001574 H-loop/switch region; other site 767462001575 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 767462001576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767462001577 S-adenosylmethionine binding site [chemical binding]; other site 767462001578 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 767462001579 catalytic residues [active] 767462001580 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 767462001581 putative tRNA-binding site [nucleotide binding]; other site 767462001582 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 767462001583 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767462001584 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767462001585 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767462001586 amino-acid N-acetyltransferase; Region: PLN02825 767462001587 RelB antitoxin; Region: RelB; cl01171 767462001588 HflC protein; Region: hflC; TIGR01932 767462001589 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 767462001590 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 767462001591 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 767462001592 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 767462001593 Potassium binding sites [ion binding]; other site 767462001594 Cesium cation binding sites [ion binding]; other site 767462001595 AIR carboxylase; Region: AIRC; pfam00731 767462001596 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 767462001597 ATP-grasp domain; Region: ATP-grasp; pfam02222 767462001598 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 767462001599 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 767462001600 ATP binding site [chemical binding]; other site 767462001601 active site 767462001602 substrate binding site [chemical binding]; other site 767462001603 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 767462001604 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 767462001605 putative active site [active] 767462001606 catalytic triad [active] 767462001607 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 767462001608 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 767462001609 dimerization interface [polypeptide binding]; other site 767462001610 ATP binding site [chemical binding]; other site 767462001611 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 767462001612 dimerization interface [polypeptide binding]; other site 767462001613 ATP binding site [chemical binding]; other site 767462001614 amidophosphoribosyltransferase; Provisional; Region: PRK07272 767462001615 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 767462001616 active site 767462001617 tetramer interface [polypeptide binding]; other site 767462001618 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767462001619 active site 767462001620 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 767462001621 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 767462001622 dimerization interface [polypeptide binding]; other site 767462001623 putative ATP binding site [chemical binding]; other site 767462001624 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 767462001625 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 767462001626 active site 767462001627 substrate binding site [chemical binding]; other site 767462001628 cosubstrate binding site; other site 767462001629 catalytic site [active] 767462001630 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 767462001631 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 767462001632 purine monophosphate binding site [chemical binding]; other site 767462001633 dimer interface [polypeptide binding]; other site 767462001634 putative catalytic residues [active] 767462001635 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 767462001636 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 767462001637 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 767462001638 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 767462001639 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 767462001640 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 767462001641 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 767462001642 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767462001643 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 767462001644 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 767462001645 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 767462001646 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 767462001647 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 767462001648 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 767462001649 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 767462001650 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 767462001651 DNA polymerase I; Provisional; Region: PRK05755 767462001652 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 767462001653 active site 767462001654 metal binding site 1 [ion binding]; metal-binding site 767462001655 putative 5' ssDNA interaction site; other site 767462001656 metal binding site 3; metal-binding site 767462001657 metal binding site 2 [ion binding]; metal-binding site 767462001658 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 767462001659 putative DNA binding site [nucleotide binding]; other site 767462001660 putative metal binding site [ion binding]; other site 767462001661 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 767462001662 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 767462001663 active site 767462001664 DNA binding site [nucleotide binding] 767462001665 catalytic site [active] 767462001666 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 767462001667 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 767462001668 DNA binding site [nucleotide binding] 767462001669 catalytic residue [active] 767462001670 H2TH interface [polypeptide binding]; other site 767462001671 putative catalytic residues [active] 767462001672 turnover-facilitating residue; other site 767462001673 intercalation triad [nucleotide binding]; other site 767462001674 8OG recognition residue [nucleotide binding]; other site 767462001675 putative reading head residues; other site 767462001676 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 767462001677 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 767462001678 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 767462001679 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 767462001680 CoA-binding site [chemical binding]; other site 767462001681 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 767462001682 ATP cone domain; Region: ATP-cone; pfam03477 767462001683 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 767462001684 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 767462001685 primosomal protein DnaI; Reviewed; Region: PRK08939 767462001686 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 767462001687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767462001688 Walker A motif; other site 767462001689 ATP binding site [chemical binding]; other site 767462001690 Walker B motif; other site 767462001691 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 767462001692 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 767462001693 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 767462001694 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 767462001695 active site 767462001696 dimer interface [polypeptide binding]; other site 767462001697 motif 1; other site 767462001698 motif 2; other site 767462001699 motif 3; other site 767462001700 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 767462001701 anticodon binding site; other site 767462001702 Domain of unknown function (DUF389); Region: DUF389; pfam04087 767462001703 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 767462001704 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 767462001705 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 767462001706 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 767462001707 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 767462001708 23S rRNA binding site [nucleotide binding]; other site 767462001709 L21 binding site [polypeptide binding]; other site 767462001710 L13 binding site [polypeptide binding]; other site 767462001711 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 767462001712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462001713 active site 767462001714 motif I; other site 767462001715 motif II; other site 767462001716 GTPase YqeH; Provisional; Region: PRK13796 767462001717 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 767462001718 GTP/Mg2+ binding site [chemical binding]; other site 767462001719 G4 box; other site 767462001720 G5 box; other site 767462001721 G1 box; other site 767462001722 Switch I region; other site 767462001723 G2 box; other site 767462001724 G3 box; other site 767462001725 Switch II region; other site 767462001726 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 767462001727 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 767462001728 active site 767462001729 (T/H)XGH motif; other site 767462001730 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767462001731 Zn2+ binding site [ion binding]; other site 767462001732 Mg2+ binding site [ion binding]; other site 767462001733 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 767462001734 hypothetical protein; Provisional; Region: PRK13670 767462001735 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 767462001736 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 767462001737 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767462001738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767462001739 active site 767462001740 phosphorylation site [posttranslational modification] 767462001741 intermolecular recognition site; other site 767462001742 dimerization interface [polypeptide binding]; other site 767462001743 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767462001744 DNA binding site [nucleotide binding] 767462001745 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767462001746 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767462001747 dimerization interface [polypeptide binding]; other site 767462001748 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767462001749 dimer interface [polypeptide binding]; other site 767462001750 phosphorylation site [posttranslational modification] 767462001751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767462001752 ATP binding site [chemical binding]; other site 767462001753 Mg2+ binding site [ion binding]; other site 767462001754 G-X-G motif; other site 767462001755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462001756 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462001757 Bacterial surface layer protein; Region: SLAP; pfam03217 767462001758 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767462001759 DNA binding site [nucleotide binding] 767462001760 active site 767462001761 Int/Topo IB signature motif; other site 767462001762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462001763 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462001764 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 767462001765 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 767462001766 putative deacylase active site [active] 767462001767 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 767462001768 Acylphosphatase; Region: Acylphosphatase; pfam00708 767462001769 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 767462001770 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 767462001771 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 767462001772 Predicted transcriptional regulators [Transcription]; Region: COG1733 767462001773 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 767462001774 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 767462001775 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 767462001776 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 767462001777 dimer interface [polypeptide binding]; other site 767462001778 motif 1; other site 767462001779 active site 767462001780 motif 2; other site 767462001781 motif 3; other site 767462001782 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 767462001783 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 767462001784 putative tRNA-binding site [nucleotide binding]; other site 767462001785 B3/4 domain; Region: B3_4; pfam03483 767462001786 tRNA synthetase B5 domain; Region: B5; smart00874 767462001787 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 767462001788 dimer interface [polypeptide binding]; other site 767462001789 motif 1; other site 767462001790 motif 3; other site 767462001791 motif 2; other site 767462001792 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 767462001793 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 767462001794 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 767462001795 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 767462001796 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 767462001797 NAD(P) binding site [chemical binding]; other site 767462001798 LDH/MDH dimer interface [polypeptide binding]; other site 767462001799 substrate binding site [chemical binding]; other site 767462001800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462001801 non-specific DNA binding site [nucleotide binding]; other site 767462001802 salt bridge; other site 767462001803 sequence-specific DNA binding site [nucleotide binding]; other site 767462001804 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 767462001805 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 767462001806 nucleotide binding site [chemical binding]; other site 767462001807 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 767462001808 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 767462001809 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 767462001810 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767462001811 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 767462001812 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 767462001813 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 767462001814 Rhomboid family; Region: Rhomboid; pfam01694 767462001815 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 767462001816 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 767462001817 active site residue [active] 767462001818 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 767462001819 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 767462001820 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 767462001821 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 767462001822 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 767462001823 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767462001824 Helix-turn-helix domain; Region: HTH_28; pfam13518 767462001825 putative transposase OrfB; Reviewed; Region: PHA02517 767462001826 HTH-like domain; Region: HTH_21; pfam13276 767462001827 Integrase core domain; Region: rve; pfam00665 767462001828 Integrase core domain; Region: rve_2; pfam13333 767462001829 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 767462001830 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 767462001831 NAD binding site [chemical binding]; other site 767462001832 homodimer interface [polypeptide binding]; other site 767462001833 active site 767462001834 substrate binding site [chemical binding]; other site 767462001835 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 767462001836 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 767462001837 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 767462001838 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 767462001839 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767462001840 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767462001841 DNA binding site [nucleotide binding] 767462001842 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 767462001843 putative dimerization interface [polypeptide binding]; other site 767462001844 putative ligand binding site [chemical binding]; other site 767462001845 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462001846 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462001847 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 767462001848 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 767462001849 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 767462001850 HPr interaction site; other site 767462001851 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767462001852 active site 767462001853 phosphorylation site [posttranslational modification] 767462001854 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 767462001855 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 767462001856 putative ligand binding site [chemical binding]; other site 767462001857 putative NAD binding site [chemical binding]; other site 767462001858 catalytic site [active] 767462001859 benzoate transport; Region: 2A0115; TIGR00895 767462001860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767462001861 putative substrate translocation pore; other site 767462001862 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 767462001863 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 767462001864 active site 767462001865 metal binding site [ion binding]; metal-binding site 767462001866 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 767462001867 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 767462001868 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767462001869 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767462001870 peptide binding site [polypeptide binding]; other site 767462001871 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767462001872 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 767462001873 Amidohydrolase; Region: Amidohydro_4; pfam13147 767462001874 active site 767462001875 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 767462001876 galactokinase; Provisional; Region: PRK05322 767462001877 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 767462001878 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 767462001879 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 767462001880 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 767462001881 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 767462001882 active site 767462001883 catalytic residues [active] 767462001884 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767462001885 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 767462001886 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767462001887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767462001888 dimer interface [polypeptide binding]; other site 767462001889 phosphorylation site [posttranslational modification] 767462001890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767462001891 ATP binding site [chemical binding]; other site 767462001892 Mg2+ binding site [ion binding]; other site 767462001893 G-X-G motif; other site 767462001894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767462001895 putative substrate translocation pore; other site 767462001896 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767462001897 OsmC-like protein; Region: OsmC; pfam02566 767462001898 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 767462001899 active site 767462001900 catalytic tetrad [active] 767462001901 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462001902 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462001903 inner membrane transporter YjeM; Provisional; Region: PRK15238 767462001904 S-ribosylhomocysteinase; Provisional; Region: PRK02260 767462001905 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 767462001906 substrate binding site [chemical binding]; other site 767462001907 THF binding site; other site 767462001908 zinc-binding site [ion binding]; other site 767462001909 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767462001910 MULE transposase domain; Region: MULE; pfam10551 767462001911 Helix-turn-helix domain; Region: HTH_17; pfam12728 767462001912 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767462001913 MULE transposase domain; Region: MULE; pfam10551 767462001914 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462001915 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 767462001916 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767462001917 ATP binding site [chemical binding]; other site 767462001918 putative Mg++ binding site [ion binding]; other site 767462001919 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767462001920 nucleotide binding region [chemical binding]; other site 767462001921 ATP-binding site [chemical binding]; other site 767462001922 HsdM N-terminal domain; Region: HsdM_N; pfam12161 767462001923 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 767462001924 Methyltransferase domain; Region: Methyltransf_26; pfam13659 767462001925 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767462001926 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 767462001927 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 767462001928 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 767462001929 putative active site [active] 767462001930 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 767462001931 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 767462001932 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 767462001933 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 767462001934 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 767462001935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462001936 dimer interface [polypeptide binding]; other site 767462001937 conserved gate region; other site 767462001938 putative PBP binding loops; other site 767462001939 ABC-ATPase subunit interface; other site 767462001940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462001941 dimer interface [polypeptide binding]; other site 767462001942 conserved gate region; other site 767462001943 putative PBP binding loops; other site 767462001944 ABC-ATPase subunit interface; other site 767462001945 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767462001946 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767462001947 Walker A/P-loop; other site 767462001948 ATP binding site [chemical binding]; other site 767462001949 Q-loop/lid; other site 767462001950 ABC transporter signature motif; other site 767462001951 Walker B; other site 767462001952 D-loop; other site 767462001953 H-loop/switch region; other site 767462001954 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 767462001955 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767462001956 substrate binding pocket [chemical binding]; other site 767462001957 membrane-bound complex binding site; other site 767462001958 hinge residues; other site 767462001959 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 767462001960 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 767462001961 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 767462001962 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767462001963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767462001964 putative substrate translocation pore; other site 767462001965 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462001966 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462001967 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 767462001968 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 767462001969 Cl- selectivity filter; other site 767462001970 Cl- binding residues [ion binding]; other site 767462001971 pore gating glutamate residue; other site 767462001972 dimer interface [polypeptide binding]; other site 767462001973 H+/Cl- coupling transport residue; other site 767462001974 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 767462001975 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 767462001976 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767462001977 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 767462001978 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462001979 motif II; other site 767462001980 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 767462001981 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 767462001982 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 767462001983 TM-ABC transporter signature motif; other site 767462001984 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 767462001985 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 767462001986 TM-ABC transporter signature motif; other site 767462001987 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 767462001988 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 767462001989 Walker A/P-loop; other site 767462001990 ATP binding site [chemical binding]; other site 767462001991 Q-loop/lid; other site 767462001992 ABC transporter signature motif; other site 767462001993 Walker B; other site 767462001994 D-loop; other site 767462001995 H-loop/switch region; other site 767462001996 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 767462001997 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 767462001998 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 767462001999 ligand binding site [chemical binding]; other site 767462002000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462002001 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462002002 Probable transposase; Region: OrfB_IS605; pfam01385 767462002003 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462002004 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462002005 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 767462002006 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 767462002007 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 767462002008 active site 2 [active] 767462002009 active site 1 [active] 767462002010 H+ Antiporter protein; Region: 2A0121; TIGR00900 767462002011 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 767462002012 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 767462002013 PemK-like protein; Region: PemK; cl00995 767462002014 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767462002015 active site 767462002016 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 767462002017 active site 767462002018 dimer interface [polypeptide binding]; other site 767462002019 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 767462002020 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 767462002021 heterodimer interface [polypeptide binding]; other site 767462002022 active site 767462002023 FMN binding site [chemical binding]; other site 767462002024 homodimer interface [polypeptide binding]; other site 767462002025 substrate binding site [chemical binding]; other site 767462002026 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 767462002027 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 767462002028 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 767462002029 dihydroorotase; Validated; Region: pyrC; PRK09357 767462002030 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767462002031 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 767462002032 active site 767462002033 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 767462002034 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 767462002035 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 767462002036 catalytic site [active] 767462002037 subunit interface [polypeptide binding]; other site 767462002038 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 767462002039 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767462002040 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 767462002041 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 767462002042 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767462002043 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767462002044 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 767462002045 IMP binding site; other site 767462002046 dimer interface [polypeptide binding]; other site 767462002047 partial ornithine binding site; other site 767462002048 Domain of unknown function (DUF955); Region: DUF955; cl01076 767462002049 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 767462002050 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 767462002051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767462002052 Coenzyme A binding pocket [chemical binding]; other site 767462002053 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 767462002054 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 767462002055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767462002056 putative substrate translocation pore; other site 767462002057 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767462002058 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 767462002059 active site 767462002060 Zn binding site [ion binding]; other site 767462002061 hypothetical protein; Provisional; Region: PRK06762 767462002062 AAA domain; Region: AAA_33; pfam13671 767462002063 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 767462002064 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 767462002065 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 767462002066 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 767462002067 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 767462002068 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 767462002069 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 767462002070 ArsC family; Region: ArsC; pfam03960 767462002071 putative ArsC-like catalytic residues; other site 767462002072 putative TRX-like catalytic residues [active] 767462002073 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 767462002074 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 767462002075 substrate binding pocket [chemical binding]; other site 767462002076 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 767462002077 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 767462002078 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 767462002079 active site 767462002080 Bacterial surface layer protein; Region: SLAP; pfam03217 767462002081 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 767462002082 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 767462002083 active site 1 [active] 767462002084 dimer interface [polypeptide binding]; other site 767462002085 hexamer interface [polypeptide binding]; other site 767462002086 active site 2 [active] 767462002087 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 767462002088 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 767462002089 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 767462002090 homodimer interface [polypeptide binding]; other site 767462002091 substrate-cofactor binding pocket; other site 767462002092 catalytic residue [active] 767462002093 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 767462002094 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 767462002095 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 767462002096 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 767462002097 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 767462002098 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 767462002099 active site 767462002100 elongation factor P; Validated; Region: PRK00529 767462002101 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 767462002102 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 767462002103 RNA binding site [nucleotide binding]; other site 767462002104 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 767462002105 RNA binding site [nucleotide binding]; other site 767462002106 transcription antitermination factor NusB; Region: nusB; TIGR01951 767462002107 putative RNA binding site [nucleotide binding]; other site 767462002108 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 767462002109 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 767462002110 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 767462002111 homodimer interface [polypeptide binding]; other site 767462002112 NADP binding site [chemical binding]; other site 767462002113 substrate binding site [chemical binding]; other site 767462002114 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 767462002115 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 767462002116 generic binding surface II; other site 767462002117 generic binding surface I; other site 767462002118 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 767462002119 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 767462002120 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 767462002121 substrate binding pocket [chemical binding]; other site 767462002122 chain length determination region; other site 767462002123 substrate-Mg2+ binding site; other site 767462002124 catalytic residues [active] 767462002125 aspartate-rich region 1; other site 767462002126 active site lid residues [active] 767462002127 aspartate-rich region 2; other site 767462002128 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 767462002129 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 767462002130 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 767462002131 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 767462002132 Walker A/P-loop; other site 767462002133 ATP binding site [chemical binding]; other site 767462002134 Q-loop/lid; other site 767462002135 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 767462002136 ABC transporter signature motif; other site 767462002137 Walker B; other site 767462002138 D-loop; other site 767462002139 H-loop/switch region; other site 767462002140 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 767462002141 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 767462002142 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 767462002143 catalytic site [active] 767462002144 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 767462002145 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 767462002146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767462002147 ATP binding site [chemical binding]; other site 767462002148 putative Mg++ binding site [ion binding]; other site 767462002149 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767462002150 nucleotide binding region [chemical binding]; other site 767462002151 ATP-binding site [chemical binding]; other site 767462002152 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 767462002153 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 767462002154 putative active site [active] 767462002155 substrate binding site [chemical binding]; other site 767462002156 putative cosubstrate binding site; other site 767462002157 catalytic site [active] 767462002158 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 767462002159 substrate binding site [chemical binding]; other site 767462002160 16S rRNA methyltransferase B; Provisional; Region: PRK14902 767462002161 NusB family; Region: NusB; pfam01029 767462002162 putative RNA binding site [nucleotide binding]; other site 767462002163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767462002164 S-adenosylmethionine binding site [chemical binding]; other site 767462002165 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 767462002166 Protein phosphatase 2C; Region: PP2C; pfam00481 767462002167 active site 767462002168 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 767462002169 Catalytic domain of Protein Kinases; Region: PKc; cd00180 767462002170 active site 767462002171 ATP binding site [chemical binding]; other site 767462002172 substrate binding site [chemical binding]; other site 767462002173 activation loop (A-loop); other site 767462002174 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 767462002175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 767462002176 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 767462002177 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 767462002178 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 767462002179 GTPase RsgA; Reviewed; Region: PRK00098 767462002180 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 767462002181 RNA binding site [nucleotide binding]; other site 767462002182 homodimer interface [polypeptide binding]; other site 767462002183 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 767462002184 GTPase/Zn-binding domain interface [polypeptide binding]; other site 767462002185 GTP/Mg2+ binding site [chemical binding]; other site 767462002186 G4 box; other site 767462002187 G5 box; other site 767462002188 G1 box; other site 767462002189 Switch I region; other site 767462002190 G2 box; other site 767462002191 G3 box; other site 767462002192 Switch II region; other site 767462002193 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 767462002194 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 767462002195 substrate binding site [chemical binding]; other site 767462002196 hexamer interface [polypeptide binding]; other site 767462002197 metal binding site [ion binding]; metal-binding site 767462002198 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 767462002199 Thiamine pyrophosphokinase; Region: TPK; cd07995 767462002200 active site 767462002201 dimerization interface [polypeptide binding]; other site 767462002202 thiamine binding site [chemical binding]; other site 767462002203 SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins...; Region: SOCS; cl02533 767462002204 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 767462002205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 767462002206 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 767462002207 DAK2 domain; Region: Dak2; pfam02734 767462002208 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 767462002209 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 767462002210 generic binding surface II; other site 767462002211 ssDNA binding site; other site 767462002212 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767462002213 ATP binding site [chemical binding]; other site 767462002214 putative Mg++ binding site [ion binding]; other site 767462002215 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767462002216 nucleotide binding region [chemical binding]; other site 767462002217 ATP-binding site [chemical binding]; other site 767462002218 putative phosphate acyltransferase; Provisional; Region: PRK05331 767462002219 acyl carrier protein; Provisional; Region: acpP; PRK00982 767462002220 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 767462002221 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 767462002222 Walker A/P-loop; other site 767462002223 ATP binding site [chemical binding]; other site 767462002224 Q-loop/lid; other site 767462002225 ABC transporter signature motif; other site 767462002226 Walker B; other site 767462002227 D-loop; other site 767462002228 H-loop/switch region; other site 767462002229 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 767462002230 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 767462002231 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 767462002232 Walker A/P-loop; other site 767462002233 ATP binding site [chemical binding]; other site 767462002234 Q-loop/lid; other site 767462002235 ABC transporter signature motif; other site 767462002236 Walker B; other site 767462002237 D-loop; other site 767462002238 H-loop/switch region; other site 767462002239 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 767462002240 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 767462002241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462002242 dimer interface [polypeptide binding]; other site 767462002243 conserved gate region; other site 767462002244 putative PBP binding loops; other site 767462002245 ABC-ATPase subunit interface; other site 767462002246 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 767462002247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462002248 dimer interface [polypeptide binding]; other site 767462002249 conserved gate region; other site 767462002250 putative PBP binding loops; other site 767462002251 ABC-ATPase subunit interface; other site 767462002252 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 767462002253 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 767462002254 peptide binding site [polypeptide binding]; other site 767462002255 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 767462002256 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 767462002257 peptide binding site [polypeptide binding]; other site 767462002258 ribonuclease III; Reviewed; Region: rnc; PRK00102 767462002259 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 767462002260 dimerization interface [polypeptide binding]; other site 767462002261 active site 767462002262 metal binding site [ion binding]; metal-binding site 767462002263 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 767462002264 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 767462002265 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 767462002266 Walker A/P-loop; other site 767462002267 ATP binding site [chemical binding]; other site 767462002268 Q-loop/lid; other site 767462002269 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 767462002270 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 767462002271 ABC transporter signature motif; other site 767462002272 Walker B; other site 767462002273 D-loop; other site 767462002274 H-loop/switch region; other site 767462002275 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 767462002276 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 767462002277 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 767462002278 P loop; other site 767462002279 GTP binding site [chemical binding]; other site 767462002280 Peptidase family C69; Region: Peptidase_C69; pfam03577 767462002281 amino acid transporter; Region: 2A0306; TIGR00909 767462002282 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 767462002283 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767462002284 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 767462002285 DNA-binding interface [nucleotide binding]; DNA binding site 767462002286 Integrase core domain; Region: rve; pfam00665 767462002287 putative DNA-binding protein; Validated; Region: PRK00118 767462002288 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 767462002289 signal recognition particle protein; Provisional; Region: PRK10867 767462002290 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 767462002291 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 767462002292 P loop; other site 767462002293 GTP binding site [chemical binding]; other site 767462002294 Signal peptide binding domain; Region: SRP_SPB; pfam02978 767462002295 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 767462002296 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 767462002297 RimM N-terminal domain; Region: RimM; pfam01782 767462002298 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 767462002299 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 767462002300 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 767462002301 active site 767462002302 Fe-S cluster binding site [ion binding]; other site 767462002303 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 767462002304 active site 767462002305 catalytic triad [active] 767462002306 oxyanion hole [active] 767462002307 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767462002308 putative DNA binding site [nucleotide binding]; other site 767462002309 LexA repressor; Validated; Region: PRK00215 767462002310 putative Zn2+ binding site [ion binding]; other site 767462002311 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 767462002312 Catalytic site [active] 767462002313 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 767462002314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 767462002315 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767462002316 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 767462002317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462002318 Walker A/P-loop; other site 767462002319 ATP binding site [chemical binding]; other site 767462002320 Q-loop/lid; other site 767462002321 ABC transporter signature motif; other site 767462002322 Walker B; other site 767462002323 D-loop; other site 767462002324 H-loop/switch region; other site 767462002325 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767462002326 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767462002327 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 767462002328 Walker A/P-loop; other site 767462002329 ATP binding site [chemical binding]; other site 767462002330 Q-loop/lid; other site 767462002331 ABC transporter signature motif; other site 767462002332 Walker B; other site 767462002333 D-loop; other site 767462002334 H-loop/switch region; other site 767462002335 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 767462002336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767462002337 S-adenosylmethionine binding site [chemical binding]; other site 767462002338 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 767462002339 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 767462002340 putative acyl-acceptor binding pocket; other site 767462002341 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 767462002342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767462002343 S-adenosylmethionine binding site [chemical binding]; other site 767462002344 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 767462002345 GIY-YIG motif/motif A; other site 767462002346 putative active site [active] 767462002347 putative metal binding site [ion binding]; other site 767462002348 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 767462002349 rRNA interaction site [nucleotide binding]; other site 767462002350 S8 interaction site; other site 767462002351 putative laminin-1 binding site; other site 767462002352 elongation factor Ts; Provisional; Region: tsf; PRK09377 767462002353 UBA/TS-N domain; Region: UBA; pfam00627 767462002354 Elongation factor TS; Region: EF_TS; pfam00889 767462002355 Elongation factor TS; Region: EF_TS; pfam00889 767462002356 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 767462002357 putative nucleotide binding site [chemical binding]; other site 767462002358 uridine monophosphate binding site [chemical binding]; other site 767462002359 homohexameric interface [polypeptide binding]; other site 767462002360 ribosome recycling factor; Reviewed; Region: frr; PRK00083 767462002361 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 767462002362 hinge region; other site 767462002363 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 767462002364 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 767462002365 RIP metalloprotease RseP; Region: TIGR00054 767462002366 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 767462002367 active site 767462002368 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 767462002369 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 767462002370 protein binding site [polypeptide binding]; other site 767462002371 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 767462002372 putative substrate binding region [chemical binding]; other site 767462002373 prolyl-tRNA synthetase; Provisional; Region: PRK09194 767462002374 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 767462002375 dimer interface [polypeptide binding]; other site 767462002376 motif 1; other site 767462002377 active site 767462002378 motif 2; other site 767462002379 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 767462002380 putative deacylase active site [active] 767462002381 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 767462002382 active site 767462002383 motif 3; other site 767462002384 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 767462002385 anticodon binding site; other site 767462002386 DNA polymerase III PolC; Validated; Region: polC; PRK00448 767462002387 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 767462002388 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 767462002389 generic binding surface II; other site 767462002390 generic binding surface I; other site 767462002391 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 767462002392 active site 767462002393 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 767462002394 active site 767462002395 catalytic site [active] 767462002396 substrate binding site [chemical binding]; other site 767462002397 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 767462002398 ribosome maturation protein RimP; Reviewed; Region: PRK00092 767462002399 Sm and related proteins; Region: Sm_like; cl00259 767462002400 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 767462002401 putative oligomer interface [polypeptide binding]; other site 767462002402 putative RNA binding site [nucleotide binding]; other site 767462002403 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 767462002404 NusA N-terminal domain; Region: NusA_N; pfam08529 767462002405 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 767462002406 RNA binding site [nucleotide binding]; other site 767462002407 homodimer interface [polypeptide binding]; other site 767462002408 NusA-like KH domain; Region: KH_5; pfam13184 767462002409 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 767462002410 G-X-X-G motif; other site 767462002411 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 767462002412 putative RNA binding cleft [nucleotide binding]; other site 767462002413 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 767462002414 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 767462002415 translation initiation factor IF-2; Region: IF-2; TIGR00487 767462002416 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 767462002417 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 767462002418 G1 box; other site 767462002419 putative GEF interaction site [polypeptide binding]; other site 767462002420 GTP/Mg2+ binding site [chemical binding]; other site 767462002421 Switch I region; other site 767462002422 G2 box; other site 767462002423 G3 box; other site 767462002424 Switch II region; other site 767462002425 G4 box; other site 767462002426 G5 box; other site 767462002427 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 767462002428 Translation-initiation factor 2; Region: IF-2; pfam11987 767462002429 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 767462002430 ribosome-binding factor A; Provisional; Region: PRK13818 767462002431 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 767462002432 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 767462002433 RNA binding site [nucleotide binding]; other site 767462002434 active site 767462002435 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 767462002436 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 767462002437 active site 767462002438 Riboflavin kinase; Region: Flavokinase; smart00904 767462002439 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 767462002440 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 767462002441 GrpE; Region: GrpE; pfam01025 767462002442 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 767462002443 dimer interface [polypeptide binding]; other site 767462002444 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 767462002445 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 767462002446 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 767462002447 nucleotide binding site [chemical binding]; other site 767462002448 NEF interaction site [polypeptide binding]; other site 767462002449 SBD interface [polypeptide binding]; other site 767462002450 chaperone protein DnaJ; Provisional; Region: PRK14276 767462002451 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 767462002452 HSP70 interaction site [polypeptide binding]; other site 767462002453 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 767462002454 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 767462002455 dimer interface [polypeptide binding]; other site 767462002456 Probable transposase; Region: OrfB_IS605; pfam01385 767462002457 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462002458 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767462002459 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462002460 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767462002461 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 767462002462 GTP-binding protein LepA; Provisional; Region: PRK05433 767462002463 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 767462002464 G1 box; other site 767462002465 putative GEF interaction site [polypeptide binding]; other site 767462002466 GTP/Mg2+ binding site [chemical binding]; other site 767462002467 Switch I region; other site 767462002468 G2 box; other site 767462002469 G3 box; other site 767462002470 Switch II region; other site 767462002471 G4 box; other site 767462002472 G5 box; other site 767462002473 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 767462002474 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 767462002475 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 767462002476 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 767462002477 active site 767462002478 catalytic site [active] 767462002479 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 767462002480 DHH family; Region: DHH; pfam01368 767462002481 DHHA1 domain; Region: DHHA1; pfam02272 767462002482 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 767462002483 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767462002484 active site 767462002485 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 767462002486 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 767462002487 dimer interface [polypeptide binding]; other site 767462002488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767462002489 catalytic residue [active] 767462002490 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 767462002491 conserved cys residue [active] 767462002492 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 767462002493 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 767462002494 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 767462002495 putative active site [active] 767462002496 catalytic site [active] 767462002497 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 767462002498 putative active site [active] 767462002499 catalytic site [active] 767462002500 Bacterial surface layer protein; Region: SLAP; pfam03217 767462002501 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 767462002502 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 767462002503 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767462002504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462002505 motif II; other site 767462002506 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767462002507 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767462002508 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767462002509 dimerization interface [polypeptide binding]; other site 767462002510 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 767462002511 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 767462002512 Sterol carrier protein domain; Region: SCP2_2; pfam13530 767462002513 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767462002514 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767462002515 dimerization interface [polypeptide binding]; other site 767462002516 PQQ-like domain; Region: PQQ_2; pfam13360 767462002517 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 767462002518 Trp docking motif [polypeptide binding]; other site 767462002519 active site 767462002520 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767462002521 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 767462002522 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767462002523 Walker A/P-loop; other site 767462002524 ATP binding site [chemical binding]; other site 767462002525 Q-loop/lid; other site 767462002526 ABC transporter signature motif; other site 767462002527 Walker B; other site 767462002528 D-loop; other site 767462002529 H-loop/switch region; other site 767462002530 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767462002531 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 767462002532 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 767462002533 nucleotide binding site [chemical binding]; other site 767462002534 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 767462002535 allosteric regulatory residue; other site 767462002536 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 767462002537 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 767462002538 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 767462002539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767462002540 catalytic residue [active] 767462002541 potential frameshift: common BLAST hit: gi|336053983|ref|YP_004562270.1| homoserine dehydrogenase 767462002542 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 767462002543 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 767462002544 homoserine kinase; Provisional; Region: PRK01212 767462002545 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767462002546 MuDR family transposase; Region: DBD_Tnp_Mut; pfam03108 767462002547 Uncharacterized conserved protein [Function unknown]; Region: COG1284 767462002548 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 767462002549 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 767462002550 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 767462002551 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 767462002552 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 767462002553 Yqey-like protein; Region: YqeY; pfam09424 767462002554 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 767462002555 PhoH-like protein; Region: PhoH; pfam02562 767462002556 metal-binding heat shock protein; Provisional; Region: PRK00016 767462002557 GTPase Era; Reviewed; Region: era; PRK00089 767462002558 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 767462002559 G1 box; other site 767462002560 GTP/Mg2+ binding site [chemical binding]; other site 767462002561 Switch I region; other site 767462002562 G2 box; other site 767462002563 Switch II region; other site 767462002564 G3 box; other site 767462002565 G4 box; other site 767462002566 G5 box; other site 767462002567 DNA repair protein RecO; Region: reco; TIGR00613 767462002568 Recombination protein O N terminal; Region: RecO_N; pfam11967 767462002569 Recombination protein O C terminal; Region: RecO_C; pfam02565 767462002570 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 767462002571 motif 1; other site 767462002572 dimer interface [polypeptide binding]; other site 767462002573 active site 767462002574 motif 2; other site 767462002575 motif 3; other site 767462002576 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 767462002577 DALR anticodon binding domain; Region: DALR_1; pfam05746 767462002578 DNA primase; Validated; Region: dnaG; PRK05667 767462002579 CHC2 zinc finger; Region: zf-CHC2; cl17510 767462002580 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 767462002581 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 767462002582 active site 767462002583 metal binding site [ion binding]; metal-binding site 767462002584 interdomain interaction site; other site 767462002585 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 767462002586 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 767462002587 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 767462002588 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767462002589 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 767462002590 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767462002591 DNA binding residues [nucleotide binding] 767462002592 Peptidase family M23; Region: Peptidase_M23; pfam01551 767462002593 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 767462002594 putative active site [active] 767462002595 nucleotide binding site [chemical binding]; other site 767462002596 nudix motif; other site 767462002597 putative metal binding site [ion binding]; other site 767462002598 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 767462002599 Family of unknown function (DUF633); Region: DUF633; pfam04816 767462002600 Uncharacterized conserved protein [Function unknown]; Region: COG0327 767462002601 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 767462002602 peptidase T; Region: peptidase-T; TIGR01882 767462002603 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 767462002604 metal binding site [ion binding]; metal-binding site 767462002605 dimer interface [polypeptide binding]; other site 767462002606 Predicted transcriptional regulators [Transcription]; Region: COG1725 767462002607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767462002608 DNA-binding site [nucleotide binding]; DNA binding site 767462002609 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 767462002610 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767462002611 Walker A/P-loop; other site 767462002612 ATP binding site [chemical binding]; other site 767462002613 Q-loop/lid; other site 767462002614 ABC transporter signature motif; other site 767462002615 Walker B; other site 767462002616 D-loop; other site 767462002617 H-loop/switch region; other site 767462002618 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 767462002619 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 767462002620 Catalytic site [active] 767462002621 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 767462002622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767462002623 S-adenosylmethionine binding site [chemical binding]; other site 767462002624 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 767462002625 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 767462002626 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 767462002627 homotetramer interface [polypeptide binding]; other site 767462002628 FMN binding site [chemical binding]; other site 767462002629 homodimer contacts [polypeptide binding]; other site 767462002630 putative active site [active] 767462002631 putative substrate binding site [chemical binding]; other site 767462002632 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 767462002633 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767462002634 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 767462002635 diphosphomevalonate decarboxylase; Region: PLN02407 767462002636 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 767462002637 mevalonate kinase; Region: mevalon_kin; TIGR00549 767462002638 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767462002639 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 767462002640 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 767462002641 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 767462002642 Part of AAA domain; Region: AAA_19; pfam13245 767462002643 Family description; Region: UvrD_C_2; pfam13538 767462002644 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 767462002645 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 767462002646 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 767462002647 active site 767462002648 catalytic site [active] 767462002649 substrate binding site [chemical binding]; other site 767462002650 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767462002651 ATP binding site [chemical binding]; other site 767462002652 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 767462002653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 767462002654 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 767462002655 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 767462002656 putative dimer interface [polypeptide binding]; other site 767462002657 putative anticodon binding site; other site 767462002658 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 767462002659 homodimer interface [polypeptide binding]; other site 767462002660 motif 1; other site 767462002661 motif 2; other site 767462002662 active site 767462002663 motif 3; other site 767462002664 Helix-turn-helix domain; Region: HTH_36; pfam13730 767462002665 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 767462002666 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 767462002667 endonuclease III; Region: ENDO3c; smart00478 767462002668 minor groove reading motif; other site 767462002669 helix-hairpin-helix signature motif; other site 767462002670 substrate binding pocket [chemical binding]; other site 767462002671 active site 767462002672 Transglycosylase; Region: Transgly; pfam00912 767462002673 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 767462002674 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 767462002675 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 767462002676 hypothetical protein; Provisional; Region: PRK13660 767462002677 DivIVA protein; Region: DivIVA; pfam05103 767462002678 DivIVA domain; Region: DivI1A_domain; TIGR03544 767462002679 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 767462002680 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 767462002681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 767462002682 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767462002683 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 767462002684 active site 767462002685 metal binding site [ion binding]; metal-binding site 767462002686 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 767462002687 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 767462002688 Potassium binding sites [ion binding]; other site 767462002689 Cesium cation binding sites [ion binding]; other site 767462002690 lipoprotein signal peptidase; Provisional; Region: PRK14797 767462002691 lipoprotein signal peptidase; Provisional; Region: PRK14787 767462002692 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 767462002693 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767462002694 RNA binding surface [nucleotide binding]; other site 767462002695 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767462002696 active site 767462002697 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 767462002698 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 767462002699 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 767462002700 catalytic site [active] 767462002701 subunit interface [polypeptide binding]; other site 767462002702 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 767462002703 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767462002704 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767462002705 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 767462002706 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767462002707 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 767462002708 IMP binding site; other site 767462002709 dimer interface [polypeptide binding]; other site 767462002710 interdomain contacts; other site 767462002711 partial ornithine binding site; other site 767462002712 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 767462002713 Domain of unknown function (DUF814); Region: DUF814; pfam05670 767462002714 EDD domain protein, DegV family; Region: DegV; TIGR00762 767462002715 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767462002716 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 767462002717 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767462002718 active site 767462002719 DNA binding site [nucleotide binding] 767462002720 Int/Topo IB signature motif; other site 767462002721 topology modulation protein; Reviewed; Region: PRK08118 767462002722 AAA domain; Region: AAA_17; pfam13207 767462002723 Bacterial surface layer protein; Region: SLAP; pfam03217 767462002724 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 767462002725 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767462002726 MULE transposase domain; Region: MULE; pfam10551 767462002727 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 767462002728 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767462002729 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462002730 non-specific DNA binding site [nucleotide binding]; other site 767462002731 salt bridge; other site 767462002732 sequence-specific DNA binding site [nucleotide binding]; other site 767462002733 GDA1/CD39 (nucleoside phosphatase) family; Region: GDA1_CD39; cl17763 767462002734 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 767462002735 active site 767462002736 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 767462002737 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 767462002738 DHHA2 domain; Region: DHHA2; pfam02833 767462002739 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767462002740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767462002741 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767462002742 dimerization interface [polypeptide binding]; other site 767462002743 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 767462002744 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 767462002745 CAP-like domain; other site 767462002746 active site 767462002747 primary dimer interface [polypeptide binding]; other site 767462002748 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767462002749 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 767462002750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767462002751 Mg2+ binding site [ion binding]; other site 767462002752 G-X-G motif; other site 767462002753 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 767462002754 anchoring element; other site 767462002755 dimer interface [polypeptide binding]; other site 767462002756 ATP binding site [chemical binding]; other site 767462002757 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 767462002758 active site 767462002759 putative metal-binding site [ion binding]; other site 767462002760 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 767462002761 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 767462002762 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 767462002763 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 767462002764 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 767462002765 dimerization interface [polypeptide binding]; other site 767462002766 DPS ferroxidase diiron center [ion binding]; other site 767462002767 ion pore; other site 767462002768 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 767462002769 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767462002770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767462002771 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767462002772 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 767462002773 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 767462002774 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 767462002775 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 767462002776 dimer interface [polypeptide binding]; other site 767462002777 FMN binding site [chemical binding]; other site 767462002778 NADPH bind site [chemical binding]; other site 767462002779 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 767462002780 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767462002781 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 767462002782 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767462002783 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767462002784 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767462002785 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 767462002786 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767462002787 active site 767462002788 DNA binding site [nucleotide binding] 767462002789 Int/Topo IB signature motif; other site 767462002790 putative transposase OrfB; Reviewed; Region: PHA02517 767462002791 HTH-like domain; Region: HTH_21; pfam13276 767462002792 Integrase core domain; Region: rve; pfam00665 767462002793 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 767462002794 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767462002795 substrate binding pocket [chemical binding]; other site 767462002796 membrane-bound complex binding site; other site 767462002797 hinge residues; other site 767462002798 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767462002799 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767462002800 Walker A/P-loop; other site 767462002801 ATP binding site [chemical binding]; other site 767462002802 Q-loop/lid; other site 767462002803 ABC transporter signature motif; other site 767462002804 Walker B; other site 767462002805 D-loop; other site 767462002806 H-loop/switch region; other site 767462002807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462002808 dimer interface [polypeptide binding]; other site 767462002809 conserved gate region; other site 767462002810 putative PBP binding loops; other site 767462002811 ABC-ATPase subunit interface; other site 767462002812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462002813 dimer interface [polypeptide binding]; other site 767462002814 conserved gate region; other site 767462002815 putative PBP binding loops; other site 767462002816 ABC-ATPase subunit interface; other site 767462002817 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 767462002818 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 767462002819 DNA binding residues [nucleotide binding] 767462002820 putative dimer interface [polypeptide binding]; other site 767462002821 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 767462002822 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 767462002823 maltose O-acetyltransferase; Provisional; Region: PRK10092 767462002824 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 767462002825 active site 767462002826 substrate binding site [chemical binding]; other site 767462002827 trimer interface [polypeptide binding]; other site 767462002828 CoA binding site [chemical binding]; other site 767462002829 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 767462002830 Amidohydrolase; Region: Amidohydro_2; pfam04909 767462002831 Abi-like protein; Region: Abi_2; pfam07751 767462002832 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 767462002833 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 767462002834 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 767462002835 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 767462002836 FMN binding site [chemical binding]; other site 767462002837 substrate binding site [chemical binding]; other site 767462002838 putative catalytic residue [active] 767462002839 recombination factor protein RarA; Reviewed; Region: PRK13342 767462002840 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767462002841 Walker A motif; other site 767462002842 ATP binding site [chemical binding]; other site 767462002843 Walker B motif; other site 767462002844 arginine finger; other site 767462002845 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 767462002846 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 767462002847 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 767462002848 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462002849 sequence-specific DNA binding site [nucleotide binding]; other site 767462002850 salt bridge; other site 767462002851 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 767462002852 endonuclease III; Region: ENDO3c; smart00478 767462002853 minor groove reading motif; other site 767462002854 helix-hairpin-helix signature motif; other site 767462002855 substrate binding pocket [chemical binding]; other site 767462002856 active site 767462002857 LytTr DNA-binding domain; Region: LytTR; smart00850 767462002858 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 767462002859 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 767462002860 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767462002861 Coenzyme A binding pocket [chemical binding]; other site 767462002862 Predicted transcriptional regulators [Transcription]; Region: COG1733 767462002863 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 767462002864 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 767462002865 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 767462002866 Beta-lactamase; Region: Beta-lactamase; pfam00144 767462002867 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767462002868 dipeptidase PepV; Reviewed; Region: PRK07318 767462002869 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 767462002870 active site 767462002871 metal binding site [ion binding]; metal-binding site 767462002872 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767462002873 HTH-like domain; Region: HTH_21; pfam13276 767462002874 Integrase core domain; Region: rve; pfam00665 767462002875 Integrase core domain; Region: rve_2; pfam13333 767462002876 Flavoprotein; Region: Flavoprotein; pfam02441 767462002877 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 767462002878 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767462002879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767462002880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767462002881 dimerization interface [polypeptide binding]; other site 767462002882 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 767462002883 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767462002884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767462002885 homodimer interface [polypeptide binding]; other site 767462002886 catalytic residue [active] 767462002887 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 767462002888 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 767462002889 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767462002890 active site 767462002891 Predicted membrane protein [Function unknown]; Region: COG1288 767462002892 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 767462002893 Bacterial surface layer protein; Region: SLAP; pfam03217 767462002894 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 767462002895 AAA ATPase domain; Region: AAA_16; pfam13191 767462002896 Uncharacterized conserved protein [Function unknown]; Region: COG3410 767462002897 S-methylmethionine transporter; Provisional; Region: PRK11387 767462002898 S-methylmethionine transporter; Provisional; Region: PRK11387 767462002899 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 767462002900 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 767462002901 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 767462002902 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 767462002903 active site 767462002904 Zn binding site [ion binding]; other site 767462002905 Acetokinase family; Region: Acetate_kinase; cl17229 767462002906 Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565 767462002907 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 767462002908 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 767462002909 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 767462002910 putative active site [active] 767462002911 catalytic triad [active] 767462002912 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 767462002913 PA/protease or protease-like domain interface [polypeptide binding]; other site 767462002914 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 767462002915 catalytic residues [active] 767462002916 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 767462002917 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 767462002918 TolA protein; Region: tolA_full; TIGR02794 767462002919 Bacterial surface layer protein; Region: SLAP; pfam03217 767462002920 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 767462002921 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 767462002922 Protein of unknown function DUF262; Region: DUF262; pfam03235 767462002923 Uncharacterized conserved protein [Function unknown]; Region: COG1479 767462002924 Uncharacterized conserved protein [Function unknown]; Region: COG3472 767462002925 putative transposase OrfB; Reviewed; Region: PHA02517 767462002926 HTH-like domain; Region: HTH_21; pfam13276 767462002927 Integrase core domain; Region: rve; pfam00665 767462002928 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767462002929 Helix-turn-helix domain; Region: HTH_28; pfam13518 767462002930 Transposase; Region: HTH_Tnp_1; cl17663 767462002931 Helix-turn-helix domain; Region: HTH_28; pfam13518 767462002932 Winged helix-turn helix; Region: HTH_29; pfam13551 767462002933 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 767462002934 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 767462002935 putative active site [active] 767462002936 putative metal binding site [ion binding]; other site 767462002937 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 767462002938 Bacterial surface layer protein; Region: SLAP; pfam03217 767462002939 potential frameshift: common BLAST hit: gi|258508148|ref|YP_003170899.1| transposase IS4 family protein 767462002940 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767462002941 DDE superfamily endonuclease; Region: DDE_5; cl17874 767462002942 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 767462002943 TIGR02687 family protein; Region: TIGR02687 767462002944 PglZ domain; Region: PglZ; pfam08665 767462002945 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 767462002946 putative active site [active] 767462002947 putative NTP binding site [chemical binding]; other site 767462002948 putative nucleic acid binding site [nucleotide binding]; other site 767462002949 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 767462002950 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 767462002951 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 767462002952 Uncharacterized conserved protein [Function unknown]; Region: COG1479 767462002953 Protein of unknown function DUF262; Region: DUF262; pfam03235 767462002954 Protein of unknown function DUF262; Region: DUF262; pfam03235 767462002955 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 767462002956 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 767462002957 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 767462002958 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 767462002959 ligand binding site [chemical binding]; other site 767462002960 flexible hinge region; other site 767462002961 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 767462002962 putative switch regulator; other site 767462002963 non-specific DNA interactions [nucleotide binding]; other site 767462002964 DNA binding site [nucleotide binding] 767462002965 sequence specific DNA binding site [nucleotide binding]; other site 767462002966 putative cAMP binding site [chemical binding]; other site 767462002967 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 767462002968 dinuclear metal binding motif [ion binding]; other site 767462002969 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 767462002970 metal-binding site [ion binding] 767462002971 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 767462002972 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767462002973 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 767462002974 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 767462002975 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767462002976 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767462002977 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 767462002978 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 767462002979 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 767462002980 M20 Peptidase Aminoacylase 1-like protein 2, amidohydrolase family; Region: M20_Acy1L2_like_2; cd09849 767462002981 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 767462002982 metal binding site [ion binding]; metal-binding site 767462002983 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 767462002984 dimer interface [polypeptide binding]; other site 767462002985 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 767462002986 metal binding site [ion binding]; metal-binding site 767462002987 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 767462002988 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 767462002989 RNAP_Rpb7_N_like: This conserved domain represents the N-terminal ribonucleoprotein (RNP) domain of the Rpb7 subunit of eukaryotic RNA polymerase (RNAP) II and its homologs, Rpa43 of eukaryotic RNAP I, Rpc25 of eukaryotic RNAP III, and RpoE (subunit E)...; Region: RNAP_Rpb7_N_like; cl04309 767462002990 SH3-like domain; Region: SH3_8; pfam13457 767462002991 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 767462002992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462002993 Walker A/P-loop; other site 767462002994 ATP binding site [chemical binding]; other site 767462002995 Q-loop/lid; other site 767462002996 ABC transporter signature motif; other site 767462002997 Walker B; other site 767462002998 D-loop; other site 767462002999 H-loop/switch region; other site 767462003000 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 767462003001 Walker A/P-loop; other site 767462003002 ATP binding site [chemical binding]; other site 767462003003 ABC transporter; Region: ABC_tran; pfam00005 767462003004 Q-loop/lid; other site 767462003005 ABC transporter signature motif; other site 767462003006 Walker B; other site 767462003007 D-loop; other site 767462003008 H-loop/switch region; other site 767462003009 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767462003010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462003011 Walker A/P-loop; other site 767462003012 ATP binding site [chemical binding]; other site 767462003013 Q-loop/lid; other site 767462003014 ABC transporter signature motif; other site 767462003015 Walker B; other site 767462003016 D-loop; other site 767462003017 H-loop/switch region; other site 767462003018 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767462003019 MULE transposase domain; Region: MULE; pfam10551 767462003020 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767462003021 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767462003022 Walker A/P-loop; other site 767462003023 ATP binding site [chemical binding]; other site 767462003024 Q-loop/lid; other site 767462003025 ABC transporter signature motif; other site 767462003026 Walker B; other site 767462003027 D-loop; other site 767462003028 H-loop/switch region; other site 767462003029 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 767462003030 LytTr DNA-binding domain; Region: LytTR; smart00850 767462003031 Probable transposase; Region: OrfB_IS605; pfam01385 767462003032 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462003033 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767462003034 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462003035 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 767462003036 putative active site [active] 767462003037 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 767462003038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462003039 Walker A/P-loop; other site 767462003040 ATP binding site [chemical binding]; other site 767462003041 Q-loop/lid; other site 767462003042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462003043 ABC transporter signature motif; other site 767462003044 Walker B; other site 767462003045 D-loop; other site 767462003046 H-loop/switch region; other site 767462003047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462003048 AAA domain; Region: AAA_21; pfam13304 767462003049 Walker A/P-loop; other site 767462003050 ATP binding site [chemical binding]; other site 767462003051 Q-loop/lid; other site 767462003052 ABC transporter signature motif; other site 767462003053 Walker B; other site 767462003054 D-loop; other site 767462003055 H-loop/switch region; other site 767462003056 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 767462003057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767462003058 Coenzyme A binding pocket [chemical binding]; other site 767462003059 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 767462003060 EVE domain; Region: EVE; cl00728 767462003061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462003062 dimer interface [polypeptide binding]; other site 767462003063 conserved gate region; other site 767462003064 ABC-ATPase subunit interface; other site 767462003065 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767462003066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462003067 Walker A/P-loop; other site 767462003068 ATP binding site [chemical binding]; other site 767462003069 Q-loop/lid; other site 767462003070 ABC transporter signature motif; other site 767462003071 Walker B; other site 767462003072 D-loop; other site 767462003073 H-loop/switch region; other site 767462003074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462003075 dimer interface [polypeptide binding]; other site 767462003076 conserved gate region; other site 767462003077 putative PBP binding loops; other site 767462003078 ABC-ATPase subunit interface; other site 767462003079 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 767462003080 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 767462003081 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 767462003082 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 767462003083 NAD(P) binding site [chemical binding]; other site 767462003084 Predicted membrane protein [Function unknown]; Region: COG2364 767462003085 Predicted membrane protein [Function unknown]; Region: COG2364 767462003086 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 767462003087 BioY family; Region: BioY; pfam02632 767462003088 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 767462003089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 767462003090 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 767462003091 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 767462003092 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 767462003093 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767462003094 active site 767462003095 DNA binding site [nucleotide binding] 767462003096 Int/Topo IB signature motif; other site 767462003097 Integrase core domain; Region: rve; pfam00665 767462003098 Integrase core domain; Region: rve_2; pfam13333 767462003099 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767462003100 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 767462003101 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767462003102 MULE transposase domain; Region: MULE; pfam10551 767462003103 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 767462003104 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767462003105 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767462003106 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535 767462003107 metal binding site [ion binding]; metal-binding site 767462003108 hypothetical protein; Provisional; Region: PRK06762 767462003109 AAA domain; Region: AAA_33; pfam13671 767462003110 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767462003111 catalytic core [active] 767462003112 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 767462003113 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 767462003114 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 767462003115 nudix motif; other site 767462003116 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 767462003117 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 767462003118 active site 767462003119 catalytic motif [active] 767462003120 Zn binding site [ion binding]; other site 767462003121 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 767462003122 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767462003123 Coenzyme A binding pocket [chemical binding]; other site 767462003124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462003125 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462003126 Probable transposase; Region: OrfB_IS605; pfam01385 767462003127 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462003128 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462003129 H+ Antiporter protein; Region: 2A0121; TIGR00900 767462003130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767462003131 putative substrate translocation pore; other site 767462003132 Fic/DOC family; Region: Fic; cl00960 767462003133 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 767462003134 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 767462003135 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 767462003136 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767462003137 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767462003138 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 767462003139 Walker A/P-loop; other site 767462003140 ATP binding site [chemical binding]; other site 767462003141 Q-loop/lid; other site 767462003142 ABC transporter signature motif; other site 767462003143 Walker B; other site 767462003144 D-loop; other site 767462003145 H-loop/switch region; other site 767462003146 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767462003147 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767462003148 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 767462003149 Walker A/P-loop; other site 767462003150 ATP binding site [chemical binding]; other site 767462003151 Q-loop/lid; other site 767462003152 ABC transporter signature motif; other site 767462003153 Walker B; other site 767462003154 D-loop; other site 767462003155 H-loop/switch region; other site 767462003156 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 767462003157 peptidase T; Region: peptidase-T; TIGR01882 767462003158 metal binding site [ion binding]; metal-binding site 767462003159 dimer interface [polypeptide binding]; other site 767462003160 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 767462003161 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 767462003162 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 767462003163 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 767462003164 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 767462003165 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 767462003166 pyridoxal binding site [chemical binding]; other site 767462003167 dimer interface [polypeptide binding]; other site 767462003168 ATP binding site [chemical binding]; other site 767462003169 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767462003170 Beta-lactamase; Region: Beta-lactamase; pfam00144 767462003171 maltose O-acetyltransferase; Provisional; Region: PRK10092 767462003172 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 767462003173 active site 767462003174 substrate binding site [chemical binding]; other site 767462003175 trimer interface [polypeptide binding]; other site 767462003176 CoA binding site [chemical binding]; other site 767462003177 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 767462003178 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 767462003179 active site 767462003180 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 767462003181 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 767462003182 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767462003183 ATP binding site [chemical binding]; other site 767462003184 putative Mg++ binding site [ion binding]; other site 767462003185 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767462003186 nucleotide binding region [chemical binding]; other site 767462003187 ATP-binding site [chemical binding]; other site 767462003188 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 767462003189 HRDC domain; Region: HRDC; pfam00570 767462003190 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767462003191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767462003192 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767462003193 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 767462003194 Aluminium resistance protein; Region: Alum_res; pfam06838 767462003195 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 767462003196 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 767462003197 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767462003198 catalytic residue [active] 767462003199 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 767462003200 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767462003201 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 767462003202 Amino acid permease; Region: AA_permease_2; pfam13520 767462003203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462003204 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462003205 Probable transposase; Region: OrfB_IS605; pfam01385 767462003206 camphor resistance protein CrcB; Provisional; Region: PRK14220 767462003207 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 767462003208 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 767462003209 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767462003210 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 767462003211 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767462003212 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 767462003213 Integrase core domain; Region: rve; pfam00665 767462003214 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 767462003215 active site 767462003216 catalytic residues [active] 767462003217 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 767462003218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767462003219 Walker A motif; other site 767462003220 ATP binding site [chemical binding]; other site 767462003221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 767462003222 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 767462003223 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 767462003224 active site 767462003225 HslU subunit interaction site [polypeptide binding]; other site 767462003226 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 767462003227 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767462003228 active site 767462003229 DNA binding site [nucleotide binding] 767462003230 Int/Topo IB signature motif; other site 767462003231 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 767462003232 Glucose inhibited division protein A; Region: GIDA; pfam01134 767462003233 DNA topoisomerase I; Validated; Region: PRK05582 767462003234 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 767462003235 active site 767462003236 interdomain interaction site; other site 767462003237 putative metal-binding site [ion binding]; other site 767462003238 nucleotide binding site [chemical binding]; other site 767462003239 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 767462003240 domain I; other site 767462003241 DNA binding groove [nucleotide binding] 767462003242 phosphate binding site [ion binding]; other site 767462003243 domain II; other site 767462003244 domain III; other site 767462003245 nucleotide binding site [chemical binding]; other site 767462003246 catalytic site [active] 767462003247 domain IV; other site 767462003248 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 767462003249 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 767462003250 DNA protecting protein DprA; Region: dprA; TIGR00732 767462003251 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 767462003252 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 767462003253 RNA/DNA hybrid binding site [nucleotide binding]; other site 767462003254 active site 767462003255 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 767462003256 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 767462003257 GTP/Mg2+ binding site [chemical binding]; other site 767462003258 G4 box; other site 767462003259 G5 box; other site 767462003260 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 767462003261 G1 box; other site 767462003262 G1 box; other site 767462003263 GTP/Mg2+ binding site [chemical binding]; other site 767462003264 Switch I region; other site 767462003265 G2 box; other site 767462003266 G2 box; other site 767462003267 Switch I region; other site 767462003268 G3 box; other site 767462003269 G3 box; other site 767462003270 Switch II region; other site 767462003271 Switch II region; other site 767462003272 G4 box; other site 767462003273 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 767462003274 hypothetical protein; Provisional; Region: PRK13672 767462003275 EDD domain protein, DegV family; Region: DegV; TIGR00762 767462003276 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767462003277 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 767462003278 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 767462003279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462003280 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462003281 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767462003282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767462003283 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767462003284 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 767462003285 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 767462003286 active site 767462003287 NTP binding site [chemical binding]; other site 767462003288 metal binding triad [ion binding]; metal-binding site 767462003289 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 767462003290 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 767462003291 Uncharacterized conserved protein [Function unknown]; Region: COG1284 767462003292 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 767462003293 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 767462003294 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 767462003295 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 767462003296 binding surface 767462003297 TPR motif; other site 767462003298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 767462003299 binding surface 767462003300 TPR motif; other site 767462003301 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 767462003302 IHF dimer interface [polypeptide binding]; other site 767462003303 IHF - DNA interface [nucleotide binding]; other site 767462003304 GTP-binding protein Der; Reviewed; Region: PRK00093 767462003305 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 767462003306 G1 box; other site 767462003307 GTP/Mg2+ binding site [chemical binding]; other site 767462003308 Switch I region; other site 767462003309 G2 box; other site 767462003310 Switch II region; other site 767462003311 G3 box; other site 767462003312 G4 box; other site 767462003313 G5 box; other site 767462003314 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 767462003315 G1 box; other site 767462003316 GTP/Mg2+ binding site [chemical binding]; other site 767462003317 Switch I region; other site 767462003318 G2 box; other site 767462003319 G3 box; other site 767462003320 Switch II region; other site 767462003321 G4 box; other site 767462003322 G5 box; other site 767462003323 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 767462003324 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 767462003325 RNA binding site [nucleotide binding]; other site 767462003326 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 767462003327 RNA binding site [nucleotide binding]; other site 767462003328 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 767462003329 RNA binding site [nucleotide binding]; other site 767462003330 cytidylate kinase; Provisional; Region: cmk; PRK00023 767462003331 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 767462003332 CMP-binding site; other site 767462003333 The sites determining sugar specificity; other site 767462003334 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767462003335 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 767462003336 Predicted membrane protein [Function unknown]; Region: COG3601 767462003337 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767462003338 RNA binding surface [nucleotide binding]; other site 767462003339 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 767462003340 pseudouridine synthase; Region: TIGR00093 767462003341 active site 767462003342 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 767462003343 ScpA/B protein; Region: ScpA_ScpB; cl00598 767462003344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 767462003345 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 767462003346 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 767462003347 active site 767462003348 Int/Topo IB signature motif; other site 767462003349 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 767462003350 S1 domain; Region: S1_2; pfam13509 767462003351 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 767462003352 RNA binding site [nucleotide binding]; other site 767462003353 MarR family; Region: MarR_2; pfam12802 767462003354 pyruvate kinase; Provisional; Region: PRK06354 767462003355 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 767462003356 domain interfaces; other site 767462003357 active site 767462003358 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 767462003359 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 767462003360 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 767462003361 active site 767462003362 ADP/pyrophosphate binding site [chemical binding]; other site 767462003363 dimerization interface [polypeptide binding]; other site 767462003364 allosteric effector site; other site 767462003365 fructose-1,6-bisphosphate binding site; other site 767462003366 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 767462003367 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 767462003368 active site 767462003369 PHP Thumb interface [polypeptide binding]; other site 767462003370 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 767462003371 generic binding surface I; other site 767462003372 generic binding surface II; other site 767462003373 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 767462003374 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 767462003375 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 767462003376 active site 767462003377 metal binding site [ion binding]; metal-binding site 767462003378 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 767462003379 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 767462003380 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 767462003381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767462003382 NAD(P) binding site [chemical binding]; other site 767462003383 active site 767462003384 ribonuclease Z; Region: RNase_Z; TIGR02651 767462003385 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 767462003386 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 767462003387 catalytic triad [active] 767462003388 catalytic triad [active] 767462003389 oxyanion hole [active] 767462003390 GTPase CgtA; Reviewed; Region: obgE; PRK12297 767462003391 GTP1/OBG; Region: GTP1_OBG; pfam01018 767462003392 Obg GTPase; Region: Obg; cd01898 767462003393 G1 box; other site 767462003394 GTP/Mg2+ binding site [chemical binding]; other site 767462003395 Switch I region; other site 767462003396 G2 box; other site 767462003397 G3 box; other site 767462003398 Switch II region; other site 767462003399 G4 box; other site 767462003400 G5 box; other site 767462003401 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 767462003402 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 767462003403 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 767462003404 GIY-YIG motif/motif A; other site 767462003405 active site 767462003406 catalytic site [active] 767462003407 putative DNA binding site [nucleotide binding]; other site 767462003408 metal binding site [ion binding]; metal-binding site 767462003409 UvrB/uvrC motif; Region: UVR; pfam02151 767462003410 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 767462003411 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 767462003412 DNA binding site [nucleotide binding] 767462003413 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767462003414 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 767462003415 Integrase core domain; Region: rve; pfam00665 767462003416 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 767462003417 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 767462003418 amino acid transporter; Region: 2A0306; TIGR00909 767462003419 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 767462003420 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 767462003421 Flavoprotein; Region: Flavoprotein; pfam02441 767462003422 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 767462003423 aromatic amino acid aminotransferase; Validated; Region: PRK07309 767462003424 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767462003425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767462003426 homodimer interface [polypeptide binding]; other site 767462003427 catalytic residue [active] 767462003428 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 767462003429 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 767462003430 dimer interface [polypeptide binding]; other site 767462003431 anticodon binding site; other site 767462003432 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 767462003433 homodimer interface [polypeptide binding]; other site 767462003434 motif 1; other site 767462003435 active site 767462003436 motif 2; other site 767462003437 GAD domain; Region: GAD; pfam02938 767462003438 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 767462003439 active site 767462003440 motif 3; other site 767462003441 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 767462003442 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 767462003443 dimer interface [polypeptide binding]; other site 767462003444 motif 1; other site 767462003445 active site 767462003446 motif 2; other site 767462003447 motif 3; other site 767462003448 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 767462003449 anticodon binding site; other site 767462003450 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 767462003451 putative active site [active] 767462003452 dimerization interface [polypeptide binding]; other site 767462003453 putative tRNAtyr binding site [nucleotide binding]; other site 767462003454 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 767462003455 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767462003456 Zn2+ binding site [ion binding]; other site 767462003457 Mg2+ binding site [ion binding]; other site 767462003458 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 767462003459 synthetase active site [active] 767462003460 NTP binding site [chemical binding]; other site 767462003461 metal binding site [ion binding]; metal-binding site 767462003462 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 767462003463 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 767462003464 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 767462003465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767462003466 S-adenosylmethionine binding site [chemical binding]; other site 767462003467 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 767462003468 putative deacylase active site [active] 767462003469 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767462003470 MULE transposase domain; Region: MULE; pfam10551 767462003471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767462003472 HTH-like domain; Region: HTH_21; pfam13276 767462003473 Integrase core domain; Region: rve; pfam00665 767462003474 Integrase core domain; Region: rve_2; pfam13333 767462003475 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 767462003476 substrate binding site [chemical binding]; other site 767462003477 Uncharacterized conserved protein [Function unknown]; Region: COG2966 767462003478 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 767462003479 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 767462003480 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 767462003481 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 767462003482 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 767462003483 hypothetical protein; Provisional; Region: PRK13661 767462003484 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767462003485 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767462003486 Walker A/P-loop; other site 767462003487 ATP binding site [chemical binding]; other site 767462003488 Q-loop/lid; other site 767462003489 ABC transporter signature motif; other site 767462003490 Walker B; other site 767462003491 D-loop; other site 767462003492 H-loop/switch region; other site 767462003493 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 767462003494 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767462003495 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767462003496 Walker A/P-loop; other site 767462003497 ATP binding site [chemical binding]; other site 767462003498 Q-loop/lid; other site 767462003499 ABC transporter signature motif; other site 767462003500 Walker B; other site 767462003501 D-loop; other site 767462003502 H-loop/switch region; other site 767462003503 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 767462003504 Protein of unknown function (DUF441); Region: DUF441; pfam04284 767462003505 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 767462003506 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 767462003507 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 767462003508 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 767462003509 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 767462003510 citrate lyase subunit gamma; Provisional; Region: PRK13253 767462003511 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 767462003512 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767462003513 active site 767462003514 nucleotide binding site [chemical binding]; other site 767462003515 HIGH motif; other site 767462003516 KMSKS motif; other site 767462003517 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 767462003518 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 767462003519 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 767462003520 transmembrane helices; other site 767462003521 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 767462003522 trimer interface [polypeptide binding]; other site 767462003523 active site 767462003524 G bulge; other site 767462003525 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 767462003526 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 767462003527 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767462003528 NAD binding site [chemical binding]; other site 767462003529 dimer interface [polypeptide binding]; other site 767462003530 substrate binding site [chemical binding]; other site 767462003531 L-aspartate oxidase; Provisional; Region: PRK06175 767462003532 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 767462003533 Predicted oxidoreductase [General function prediction only]; Region: COG3573 767462003534 fumarate hydratase; Reviewed; Region: fumC; PRK00485 767462003535 Class II fumarases; Region: Fumarase_classII; cd01362 767462003536 active site 767462003537 tetramer interface [polypeptide binding]; other site 767462003538 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 767462003539 AAA domain; Region: AAA_14; pfam13173 767462003540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462003541 dimer interface [polypeptide binding]; other site 767462003542 conserved gate region; other site 767462003543 ABC-ATPase subunit interface; other site 767462003544 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 767462003545 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 767462003546 Walker A/P-loop; other site 767462003547 ATP binding site [chemical binding]; other site 767462003548 Q-loop/lid; other site 767462003549 ABC transporter signature motif; other site 767462003550 Walker B; other site 767462003551 D-loop; other site 767462003552 H-loop/switch region; other site 767462003553 NIL domain; Region: NIL; pfam09383 767462003554 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 767462003555 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 767462003556 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 767462003557 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767462003558 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462003559 motif I; other site 767462003560 motif II; other site 767462003561 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 767462003562 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 767462003563 folate binding site [chemical binding]; other site 767462003564 NADP+ binding site [chemical binding]; other site 767462003565 thymidylate synthase; Region: thym_sym; TIGR03284 767462003566 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 767462003567 dimerization interface [polypeptide binding]; other site 767462003568 active site 767462003569 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 767462003570 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 767462003571 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 767462003572 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 767462003573 active site 767462003574 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 767462003575 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 767462003576 active site 767462003577 EDD domain protein, DegV family; Region: DegV; TIGR00762 767462003578 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767462003579 enolase; Provisional; Region: eno; PRK00077 767462003580 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 767462003581 dimer interface [polypeptide binding]; other site 767462003582 metal binding site [ion binding]; metal-binding site 767462003583 substrate binding pocket [chemical binding]; other site 767462003584 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767462003585 MULE transposase domain; Region: MULE; pfam10551 767462003586 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 767462003587 FMN binding site [chemical binding]; other site 767462003588 dimer interface [polypeptide binding]; other site 767462003589 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 767462003590 beta-galactosidase; Region: BGL; TIGR03356 767462003591 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 767462003592 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 767462003593 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767462003594 DNA-binding site [nucleotide binding]; DNA binding site 767462003595 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 767462003596 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 767462003597 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 767462003598 nudix motif; other site 767462003599 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 767462003600 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 767462003601 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 767462003602 active site 767462003603 Isochorismatase family; Region: Isochorismatase; pfam00857 767462003604 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 767462003605 catalytic triad [active] 767462003606 conserved cis-peptide bond; other site 767462003607 FAD binding domain; Region: FAD_binding_4; pfam01565 767462003608 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 767462003609 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 767462003610 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767462003611 DNA-binding site [nucleotide binding]; DNA binding site 767462003612 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 767462003613 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 767462003614 beta-galactosidase; Region: BGL; TIGR03356 767462003615 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 767462003616 active site 767462003617 dimerization interface [polypeptide binding]; other site 767462003618 FMN-binding domain; Region: FMN_bind; cl01081 767462003619 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 767462003620 nucleophilic elbow; other site 767462003621 catalytic triad; other site 767462003622 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 767462003623 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 767462003624 nudix motif; other site 767462003625 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767462003626 Beta-lactamase; Region: Beta-lactamase; pfam00144 767462003627 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 767462003628 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 767462003629 aromatic amino acid aminotransferase; Validated; Region: PRK07309 767462003630 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767462003631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767462003632 homodimer interface [polypeptide binding]; other site 767462003633 catalytic residue [active] 767462003634 dihydrodipicolinate reductase; Provisional; Region: PRK00048 767462003635 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 767462003636 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 767462003637 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 767462003638 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 767462003639 dimer interface [polypeptide binding]; other site 767462003640 active site 767462003641 catalytic residue [active] 767462003642 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 767462003643 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 767462003644 metal binding site [ion binding]; metal-binding site 767462003645 putative dimer interface [polypeptide binding]; other site 767462003646 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 767462003647 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 767462003648 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 767462003649 active site 767462003650 trimer interface [polypeptide binding]; other site 767462003651 substrate binding site [chemical binding]; other site 767462003652 CoA binding site [chemical binding]; other site 767462003653 diaminopimelate decarboxylase; Region: lysA; TIGR01048 767462003654 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 767462003655 active site 767462003656 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 767462003657 substrate binding site [chemical binding]; other site 767462003658 catalytic residues [active] 767462003659 dimer interface [polypeptide binding]; other site 767462003660 aspartate kinase; Reviewed; Region: PRK09034 767462003661 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 767462003662 putative catalytic residues [active] 767462003663 putative nucleotide binding site [chemical binding]; other site 767462003664 putative aspartate binding site [chemical binding]; other site 767462003665 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 767462003666 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 767462003667 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 767462003668 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 767462003669 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 767462003670 inner membrane transporter YjeM; Provisional; Region: PRK15238 767462003671 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 767462003672 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 767462003673 G1 box; other site 767462003674 GTP/Mg2+ binding site [chemical binding]; other site 767462003675 Switch I region; other site 767462003676 G2 box; other site 767462003677 G3 box; other site 767462003678 Switch II region; other site 767462003679 G4 box; other site 767462003680 G5 box; other site 767462003681 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 767462003682 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 767462003683 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 767462003684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767462003685 Walker A motif; other site 767462003686 ATP binding site [chemical binding]; other site 767462003687 Walker B motif; other site 767462003688 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 767462003689 trigger factor; Provisional; Region: tig; PRK01490 767462003690 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 767462003691 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 767462003692 elongation factor Tu; Reviewed; Region: PRK00049 767462003693 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 767462003694 G1 box; other site 767462003695 GEF interaction site [polypeptide binding]; other site 767462003696 GTP/Mg2+ binding site [chemical binding]; other site 767462003697 Switch I region; other site 767462003698 G2 box; other site 767462003699 G3 box; other site 767462003700 Switch II region; other site 767462003701 G4 box; other site 767462003702 G5 box; other site 767462003703 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 767462003704 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 767462003705 Antibiotic Binding Site [chemical binding]; other site 767462003706 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 767462003707 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767462003708 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 767462003709 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 767462003710 16S/18S rRNA binding site [nucleotide binding]; other site 767462003711 S13e-L30e interaction site [polypeptide binding]; other site 767462003712 25S rRNA binding site [nucleotide binding]; other site 767462003713 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 767462003714 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 767462003715 DNA polymerase III, delta subunit; Region: holA; TIGR01128 767462003716 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 767462003717 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 767462003718 Competence protein; Region: Competence; pfam03772 767462003719 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 767462003720 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767462003721 SLBB domain; Region: SLBB; pfam10531 767462003722 comEA protein; Region: comE; TIGR01259 767462003723 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 767462003724 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 767462003725 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 767462003726 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 767462003727 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 767462003728 active site 767462003729 (T/H)XGH motif; other site 767462003730 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 767462003731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767462003732 S-adenosylmethionine binding site [chemical binding]; other site 767462003733 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 767462003734 cell division protein FtsW; Region: ftsW; TIGR02614 767462003735 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 767462003736 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 767462003737 G1 box; other site 767462003738 putative GEF interaction site [polypeptide binding]; other site 767462003739 GTP/Mg2+ binding site [chemical binding]; other site 767462003740 Switch I region; other site 767462003741 G2 box; other site 767462003742 G3 box; other site 767462003743 Switch II region; other site 767462003744 G4 box; other site 767462003745 G5 box; other site 767462003746 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 767462003747 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 767462003748 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 767462003749 active site 767462003750 catalytic residues [active] 767462003751 metal binding site [ion binding]; metal-binding site 767462003752 hypothetical protein; Provisional; Region: PRK13667 767462003753 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 767462003754 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 767462003755 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 767462003756 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 767462003757 AAA domain; Region: AAA_30; pfam13604 767462003758 Family description; Region: UvrD_C_2; pfam13538 767462003759 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767462003760 binding surface 767462003761 TPR motif; other site 767462003762 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767462003763 catalytic core [active] 767462003764 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 767462003765 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 767462003766 Putative amino acid metabolism; Region: DUF1831; pfam08866 767462003767 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 767462003768 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 767462003769 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767462003770 catalytic residue [active] 767462003771 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 767462003772 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 767462003773 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 767462003774 dimer interface [polypeptide binding]; other site 767462003775 ADP-ribose binding site [chemical binding]; other site 767462003776 active site 767462003777 nudix motif; other site 767462003778 metal binding site [ion binding]; metal-binding site 767462003779 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 767462003780 DNA-binding site [nucleotide binding]; DNA binding site 767462003781 RNA-binding motif; other site 767462003782 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 767462003783 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767462003784 active site 767462003785 HIGH motif; other site 767462003786 nucleotide binding site [chemical binding]; other site 767462003787 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 767462003788 active site 767462003789 KMSKS motif; other site 767462003790 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 767462003791 tRNA binding surface [nucleotide binding]; other site 767462003792 anticodon binding site; other site 767462003793 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 767462003794 DivIVA protein; Region: DivIVA; pfam05103 767462003795 DivIVA domain; Region: DivI1A_domain; TIGR03544 767462003796 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 767462003797 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 767462003798 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767462003799 RNA binding surface [nucleotide binding]; other site 767462003800 YGGT family; Region: YGGT; pfam02325 767462003801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 767462003802 cell division protein FtsZ; Validated; Region: PRK09330 767462003803 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 767462003804 nucleotide binding site [chemical binding]; other site 767462003805 SulA interaction site; other site 767462003806 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 767462003807 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 767462003808 nucleotide binding site [chemical binding]; other site 767462003809 Cell division protein FtsA; Region: FtsA; cl17206 767462003810 Cell division protein FtsA; Region: FtsA; pfam14450 767462003811 Cell division protein FtsQ; Region: FtsQ; pfam03799 767462003812 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 767462003813 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 767462003814 active site 767462003815 homodimer interface [polypeptide binding]; other site 767462003816 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 767462003817 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767462003818 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767462003819 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 767462003820 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 767462003821 Mg++ binding site [ion binding]; other site 767462003822 putative catalytic motif [active] 767462003823 putative substrate binding site [chemical binding]; other site 767462003824 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 767462003825 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 767462003826 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767462003827 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 767462003828 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 767462003829 Cell division protein FtsL; Region: FtsL; cl11433 767462003830 MraW methylase family; Region: Methyltransf_5; pfam01795 767462003831 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 767462003832 cell division protein MraZ; Reviewed; Region: PRK00326 767462003833 MraZ protein; Region: MraZ; pfam02381 767462003834 MraZ protein; Region: MraZ; pfam02381 767462003835 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 767462003836 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 767462003837 rod shape-determining protein MreC; Provisional; Region: PRK13922 767462003838 rod shape-determining protein MreC; Region: MreC; pfam04085 767462003839 rod shape-determining protein MreB; Provisional; Region: PRK13927 767462003840 MreB and similar proteins; Region: MreB_like; cd10225 767462003841 nucleotide binding site [chemical binding]; other site 767462003842 Mg binding site [ion binding]; other site 767462003843 putative protofilament interaction site [polypeptide binding]; other site 767462003844 RodZ interaction site [polypeptide binding]; other site 767462003845 DNA repair protein radc; Region: radc; TIGR00608 767462003846 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 767462003847 MPN+ (JAMM) motif; other site 767462003848 Zinc-binding site [ion binding]; other site 767462003849 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 767462003850 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462003851 motif II; other site 767462003852 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 767462003853 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767462003854 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767462003855 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 767462003856 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767462003857 active site 767462003858 HIGH motif; other site 767462003859 nucleotide binding site [chemical binding]; other site 767462003860 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 767462003861 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 767462003862 active site 767462003863 KMSKS motif; other site 767462003864 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 767462003865 tRNA binding surface [nucleotide binding]; other site 767462003866 anticodon binding site; other site 767462003867 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 767462003868 Toxin ToxN, type III toxin-antitoxin system; Region: ToxN_toxin; pfam13958 767462003869 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 767462003870 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 767462003871 Ligand binding site; other site 767462003872 Putative Catalytic site; other site 767462003873 DXD motif; other site 767462003874 Predicted membrane protein [Function unknown]; Region: COG2246 767462003875 GtrA-like protein; Region: GtrA; pfam04138 767462003876 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 767462003877 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 767462003878 active site 767462003879 catalytic site [active] 767462003880 metal binding site [ion binding]; metal-binding site 767462003881 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767462003882 MULE transposase domain; Region: MULE; pfam10551 767462003883 FMN-binding domain; Region: FMN_bind; pfam04205 767462003884 L-aspartate oxidase; Provisional; Region: PRK06175 767462003885 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767462003886 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767462003887 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767462003888 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767462003889 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462003890 non-specific DNA binding site [nucleotide binding]; other site 767462003891 salt bridge; other site 767462003892 sequence-specific DNA binding site [nucleotide binding]; other site 767462003893 potential frameshift: common BLAST hit: gi|295692650|ref|YP_003601260.1| regulatory protein munl 767462003894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462003895 non-specific DNA binding site [nucleotide binding]; other site 767462003896 salt bridge; other site 767462003897 sequence-specific DNA binding site [nucleotide binding]; other site 767462003898 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767462003899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462003900 non-specific DNA binding site [nucleotide binding]; other site 767462003901 salt bridge; other site 767462003902 sequence-specific DNA binding site [nucleotide binding]; other site 767462003903 Protein of unknown function (DUF3232); Region: DUF3232; pfam11554 767462003904 Bacterial surface layer protein; Region: SLAP; pfam03217 767462003905 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767462003906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462003907 non-specific DNA binding site [nucleotide binding]; other site 767462003908 salt bridge; other site 767462003909 sequence-specific DNA binding site [nucleotide binding]; other site 767462003910 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 767462003911 potential frameshift: common BLAST hit: gi|295692652|ref|YP_003601262.1| transcriptional regulator 767462003912 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 767462003913 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767462003914 RNA binding surface [nucleotide binding]; other site 767462003915 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 767462003916 active site 767462003917 uracil binding [chemical binding]; other site 767462003918 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767462003919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462003920 non-specific DNA binding site [nucleotide binding]; other site 767462003921 salt bridge; other site 767462003922 sequence-specific DNA binding site [nucleotide binding]; other site 767462003923 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 767462003924 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 767462003925 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 767462003926 Ligand Binding Site [chemical binding]; other site 767462003927 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 767462003928 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 767462003929 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767462003930 catalytic residue [active] 767462003931 septation ring formation regulator EzrA; Provisional; Region: PRK04778 767462003932 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 767462003933 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 767462003934 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767462003935 RNA binding surface [nucleotide binding]; other site 767462003936 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 767462003937 recombination factor protein RarA; Reviewed; Region: PRK13342 767462003938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767462003939 Walker A motif; other site 767462003940 ATP binding site [chemical binding]; other site 767462003941 Walker B motif; other site 767462003942 arginine finger; other site 767462003943 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 767462003944 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767462003945 Ligand Binding Site [chemical binding]; other site 767462003946 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 767462003947 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 767462003948 hypothetical protein; Provisional; Region: PRK14379 767462003949 rod shape-determining protein MreB; Provisional; Region: PRK13930 767462003950 MreB and similar proteins; Region: MreB_like; cd10225 767462003951 nucleotide binding site [chemical binding]; other site 767462003952 Mg binding site [ion binding]; other site 767462003953 putative protofilament interaction site [polypeptide binding]; other site 767462003954 RodZ interaction site [polypeptide binding]; other site 767462003955 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 767462003956 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 767462003957 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 767462003958 gamma subunit interface [polypeptide binding]; other site 767462003959 epsilon subunit interface [polypeptide binding]; other site 767462003960 LBP interface [polypeptide binding]; other site 767462003961 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 767462003962 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 767462003963 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 767462003964 alpha subunit interaction interface [polypeptide binding]; other site 767462003965 Walker A motif; other site 767462003966 ATP binding site [chemical binding]; other site 767462003967 Walker B motif; other site 767462003968 inhibitor binding site; inhibition site 767462003969 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 767462003970 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 767462003971 core domain interface [polypeptide binding]; other site 767462003972 delta subunit interface [polypeptide binding]; other site 767462003973 epsilon subunit interface [polypeptide binding]; other site 767462003974 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 767462003975 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 767462003976 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 767462003977 beta subunit interaction interface [polypeptide binding]; other site 767462003978 Walker A motif; other site 767462003979 ATP binding site [chemical binding]; other site 767462003980 Walker B motif; other site 767462003981 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 767462003982 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 767462003983 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 767462003984 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 767462003985 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 767462003986 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 767462003987 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 767462003988 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767462003989 active site 767462003990 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 767462003991 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 767462003992 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 767462003993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767462003994 S-adenosylmethionine binding site [chemical binding]; other site 767462003995 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 767462003996 peptide chain release factor 1; Validated; Region: prfA; PRK00591 767462003997 This domain is found in peptide chain release factors; Region: PCRF; smart00937 767462003998 RF-1 domain; Region: RF-1; pfam00472 767462003999 thymidine kinase; Provisional; Region: PRK04296 767462004000 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767462004001 Beta-lactamase; Region: Beta-lactamase; pfam00144 767462004002 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767462004003 MULE transposase domain; Region: MULE; pfam10551 767462004004 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462004005 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462004006 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767462004007 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767462004008 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767462004009 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 767462004010 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 767462004011 active site 767462004012 dimer interface [polypeptide binding]; other site 767462004013 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 767462004014 dimer interface [polypeptide binding]; other site 767462004015 active site 767462004016 VanZ like family; Region: VanZ; pfam04892 767462004017 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 767462004018 Sulfatase; Region: Sulfatase; pfam00884 767462004019 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767462004020 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 767462004021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767462004022 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767462004023 dimerization interface [polypeptide binding]; other site 767462004024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767462004025 dimer interface [polypeptide binding]; other site 767462004026 phosphorylation site [posttranslational modification] 767462004027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767462004028 ATP binding site [chemical binding]; other site 767462004029 Mg2+ binding site [ion binding]; other site 767462004030 G-X-G motif; other site 767462004031 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767462004032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767462004033 active site 767462004034 phosphorylation site [posttranslational modification] 767462004035 intermolecular recognition site; other site 767462004036 dimerization interface [polypeptide binding]; other site 767462004037 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767462004038 DNA binding site [nucleotide binding] 767462004039 SdpI/YhfL protein family; Region: SdpI; pfam13630 767462004040 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 767462004041 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 767462004042 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 767462004043 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767462004044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767462004045 homodimer interface [polypeptide binding]; other site 767462004046 catalytic residue [active] 767462004047 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 767462004048 propionate/acetate kinase; Provisional; Region: PRK12379 767462004049 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 767462004050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767462004051 S-adenosylmethionine binding site [chemical binding]; other site 767462004052 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 767462004053 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 767462004054 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 767462004055 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 767462004056 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 767462004057 Type II/IV secretion system protein; Region: T2SE; pfam00437 767462004058 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 767462004059 Walker A motif; other site 767462004060 ATP binding site [chemical binding]; other site 767462004061 Walker B motif; other site 767462004062 hypothetical protein; Validated; Region: PRK00110 767462004063 Predicted integral membrane protein [Function unknown]; Region: COG5652 767462004064 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 767462004065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462004066 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462004067 Probable transposase; Region: OrfB_IS605; pfam01385 767462004068 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462004069 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462004070 Amino acid permease; Region: AA_permease_2; pfam13520 767462004071 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 767462004072 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 767462004073 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 767462004074 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 767462004075 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767462004076 active site turn [active] 767462004077 phosphorylation site [posttranslational modification] 767462004078 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767462004079 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 767462004080 HPr interaction site; other site 767462004081 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767462004082 active site 767462004083 phosphorylation site [posttranslational modification] 767462004084 transcriptional antiterminator BglG; Provisional; Region: PRK09772 767462004085 CAT RNA binding domain; Region: CAT_RBD; smart01061 767462004086 PRD domain; Region: PRD; pfam00874 767462004087 PRD domain; Region: PRD; pfam00874 767462004088 glycerate kinase; Region: TIGR00045 767462004089 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 767462004090 Low molecular weight phosphatase family; Region: LMWPc; cd00115 767462004091 active site 767462004092 clostripain; Region: clostrip; TIGR02806 767462004093 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 767462004094 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462004095 active site 767462004096 motif I; other site 767462004097 motif II; other site 767462004098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462004099 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 767462004100 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462004101 active site 767462004102 motif I; other site 767462004103 motif II; other site 767462004104 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 767462004105 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 767462004106 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 767462004107 active site 767462004108 substrate binding site [chemical binding]; other site 767462004109 metal binding site [ion binding]; metal-binding site 767462004110 YbbR-like protein; Region: YbbR; pfam07949 767462004111 YbbR-like protein; Region: YbbR; pfam07949 767462004112 YbbR-like protein; Region: YbbR; pfam07949 767462004113 Uncharacterized conserved protein [Function unknown]; Region: COG1624 767462004114 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 767462004115 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 767462004116 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 767462004117 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 767462004118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462004119 dimer interface [polypeptide binding]; other site 767462004120 conserved gate region; other site 767462004121 putative PBP binding loops; other site 767462004122 ABC-ATPase subunit interface; other site 767462004123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462004124 dimer interface [polypeptide binding]; other site 767462004125 conserved gate region; other site 767462004126 putative PBP binding loops; other site 767462004127 ABC-ATPase subunit interface; other site 767462004128 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 767462004129 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 767462004130 Walker A/P-loop; other site 767462004131 ATP binding site [chemical binding]; other site 767462004132 Q-loop/lid; other site 767462004133 ABC transporter signature motif; other site 767462004134 Walker B; other site 767462004135 D-loop; other site 767462004136 H-loop/switch region; other site 767462004137 TOBE domain; Region: TOBE_2; pfam08402 767462004138 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 767462004139 FAD binding domain; Region: FAD_binding_4; pfam01565 767462004140 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 767462004141 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 767462004142 active site 767462004143 catalytic site [active] 767462004144 substrate binding site [chemical binding]; other site 767462004145 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 767462004146 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 767462004147 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 767462004148 ligand binding site [chemical binding]; other site 767462004149 active site 767462004150 UGI interface [polypeptide binding]; other site 767462004151 catalytic site [active] 767462004152 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462004153 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767462004154 active site 767462004155 motif I; other site 767462004156 motif II; other site 767462004157 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767462004158 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 767462004159 triosephosphate isomerase; Provisional; Region: PRK14567 767462004160 substrate binding site [chemical binding]; other site 767462004161 dimer interface [polypeptide binding]; other site 767462004162 catalytic triad [active] 767462004163 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 767462004164 Phosphoglycerate kinase; Region: PGK; pfam00162 767462004165 substrate binding site [chemical binding]; other site 767462004166 hinge regions; other site 767462004167 ADP binding site [chemical binding]; other site 767462004168 catalytic site [active] 767462004169 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 767462004170 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 767462004171 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 767462004172 Predicted transcriptional regulator [Transcription]; Region: COG3388 767462004173 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 767462004174 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 767462004175 inner membrane transporter YjeM; Provisional; Region: PRK15238 767462004176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 767462004177 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767462004178 active site 767462004179 motif I; other site 767462004180 motif II; other site 767462004181 SH3-like domain; Region: SH3_8; pfam13457 767462004182 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 767462004183 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767462004184 MULE transposase domain; Region: MULE; pfam10551 767462004185 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 767462004186 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 767462004187 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 767462004188 oligomer interface [polypeptide binding]; other site 767462004189 active site residues [active] 767462004190 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767462004191 HTH-like domain; Region: HTH_21; pfam13276 767462004192 Integrase core domain; Region: rve; pfam00665 767462004193 Integrase core domain; Region: rve_2; pfam13333 767462004194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 767462004195 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 767462004196 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 767462004197 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 767462004198 putative substrate binding pocket [chemical binding]; other site 767462004199 dimer interface [polypeptide binding]; other site 767462004200 phosphate binding site [ion binding]; other site 767462004201 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 767462004202 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 767462004203 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 767462004204 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 767462004205 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 767462004206 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 767462004207 excinuclease ABC subunit B; Provisional; Region: PRK05298 767462004208 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 767462004209 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767462004210 ATP-binding site [chemical binding]; other site 767462004211 ATP binding site [chemical binding]; other site 767462004212 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767462004213 nucleotide binding region [chemical binding]; other site 767462004214 ATP-binding site [chemical binding]; other site 767462004215 Ultra-violet resistance protein B; Region: UvrB; pfam12344 767462004216 UvrB/uvrC motif; Region: UVR; pfam02151 767462004217 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 767462004218 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 767462004219 active site 767462004220 substrate binding site [chemical binding]; other site 767462004221 metal binding site [ion binding]; metal-binding site 767462004222 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 767462004223 sulfate 1 binding site; other site 767462004224 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 767462004225 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 767462004226 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 767462004227 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 767462004228 HPr kinase/phosphorylase; Provisional; Region: PRK05428 767462004229 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 767462004230 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 767462004231 Hpr binding site; other site 767462004232 active site 767462004233 homohexamer subunit interaction site [polypeptide binding]; other site 767462004234 peptide chain release factor 2; Provisional; Region: PRK05589 767462004235 This domain is found in peptide chain release factors; Region: PCRF; smart00937 767462004236 RF-1 domain; Region: RF-1; pfam00472 767462004237 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 767462004238 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 767462004239 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767462004240 nucleotide binding region [chemical binding]; other site 767462004241 ATP-binding site [chemical binding]; other site 767462004242 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 767462004243 30S subunit binding site; other site 767462004244 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 767462004245 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767462004246 active site 767462004247 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767462004248 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767462004249 ATP binding site [chemical binding]; other site 767462004250 putative Mg++ binding site [ion binding]; other site 767462004251 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767462004252 nucleotide binding region [chemical binding]; other site 767462004253 ATP-binding site [chemical binding]; other site 767462004254 Uncharacterized conserved protein [Function unknown]; Region: COG1739 767462004255 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 767462004256 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 767462004257 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 767462004258 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 767462004259 Mg++ binding site [ion binding]; other site 767462004260 putative catalytic motif [active] 767462004261 substrate binding site [chemical binding]; other site 767462004262 phosphodiesterase; Provisional; Region: PRK12704 767462004263 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767462004264 Zn2+ binding site [ion binding]; other site 767462004265 Mg2+ binding site [ion binding]; other site 767462004266 recombinase A; Provisional; Region: recA; PRK09354 767462004267 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 767462004268 hexamer interface [polypeptide binding]; other site 767462004269 Walker A motif; other site 767462004270 ATP binding site [chemical binding]; other site 767462004271 Walker B motif; other site 767462004272 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 767462004273 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 767462004274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462004275 non-specific DNA binding site [nucleotide binding]; other site 767462004276 salt bridge; other site 767462004277 sequence-specific DNA binding site [nucleotide binding]; other site 767462004278 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 767462004279 classical (c) SDRs; Region: SDR_c; cd05233 767462004280 NAD(P) binding site [chemical binding]; other site 767462004281 active site 767462004282 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 767462004283 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 767462004284 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 767462004285 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 767462004286 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 767462004287 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 767462004288 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 767462004289 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 767462004290 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 767462004291 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 767462004292 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 767462004293 Domain of unknown function DUF20; Region: UPF0118; pfam01594 767462004294 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 767462004295 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 767462004296 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 767462004297 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767462004298 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 767462004299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462004300 motif II; other site 767462004301 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 767462004302 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 767462004303 myosin-cross-reactive antigen; Provisional; Region: PRK13977 767462004304 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767462004305 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767462004306 active site 767462004307 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 767462004308 ATP-NAD kinase; Region: NAD_kinase; pfam01513 767462004309 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 767462004310 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 767462004311 synthetase active site [active] 767462004312 NTP binding site [chemical binding]; other site 767462004313 metal binding site [ion binding]; metal-binding site 767462004314 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 767462004315 putative active site [active] 767462004316 putative metal binding residues [ion binding]; other site 767462004317 signature motif; other site 767462004318 putative triphosphate binding site [ion binding]; other site 767462004319 Thioredoxin; Region: Thioredoxin_5; pfam13743 767462004320 Competence protein CoiA-like family; Region: CoiA; cl11541 767462004321 adaptor protein; Provisional; Region: PRK02315 767462004322 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 767462004323 ArsC family; Region: ArsC; pfam03960 767462004324 putative catalytic residues [active] 767462004325 thiol/disulfide switch; other site 767462004326 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 767462004327 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 767462004328 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 767462004329 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 767462004330 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 767462004331 dimerization domain swap beta strand [polypeptide binding]; other site 767462004332 regulatory protein interface [polypeptide binding]; other site 767462004333 active site 767462004334 regulatory phosphorylation site [posttranslational modification]; other site 767462004335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767462004336 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767462004337 Walker A motif; other site 767462004338 ATP binding site [chemical binding]; other site 767462004339 Walker B motif; other site 767462004340 arginine finger; other site 767462004341 UvrB/uvrC motif; Region: UVR; pfam02151 767462004342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767462004343 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767462004344 Walker A motif; other site 767462004345 ATP binding site [chemical binding]; other site 767462004346 Walker B motif; other site 767462004347 arginine finger; other site 767462004348 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 767462004349 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 767462004350 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 767462004351 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 767462004352 G1 box; other site 767462004353 putative GEF interaction site [polypeptide binding]; other site 767462004354 GTP/Mg2+ binding site [chemical binding]; other site 767462004355 Switch I region; other site 767462004356 G2 box; other site 767462004357 G3 box; other site 767462004358 Switch II region; other site 767462004359 G4 box; other site 767462004360 G5 box; other site 767462004361 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 767462004362 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 767462004363 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 767462004364 Transporter associated domain; Region: CorC_HlyC; pfam03471 767462004365 Flavoprotein; Region: Flavoprotein; cl08021 767462004366 recombination regulator RecX; Provisional; Region: recX; PRK14135 767462004367 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 767462004368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767462004369 S-adenosylmethionine binding site [chemical binding]; other site 767462004370 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 767462004371 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767462004372 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 767462004373 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767462004374 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 767462004375 hydrolase; Region: PLN02811 767462004376 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 767462004377 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 767462004378 dimer interface [polypeptide binding]; other site 767462004379 active site 767462004380 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 767462004381 homodimer interface [polypeptide binding]; other site 767462004382 catalytic residues [active] 767462004383 NAD binding site [chemical binding]; other site 767462004384 substrate binding pocket [chemical binding]; other site 767462004385 flexible flap; other site 767462004386 putative acyltransferase; Provisional; Region: PRK05790 767462004387 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 767462004388 dimer interface [polypeptide binding]; other site 767462004389 active site 767462004390 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 767462004391 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 767462004392 active site 767462004393 tetramer interface; other site 767462004394 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 767462004395 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 767462004396 active site 767462004397 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 767462004398 Predicted membrane protein [Function unknown]; Region: COG2246 767462004399 GtrA-like protein; Region: GtrA; pfam04138 767462004400 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 767462004401 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 767462004402 active site 767462004403 homodimer interface [polypeptide binding]; other site 767462004404 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 767462004405 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 767462004406 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767462004407 DEAD/DEAH box helicase; Region: DEAD; pfam00270 767462004408 ATP binding site [chemical binding]; other site 767462004409 putative Mg++ binding site [ion binding]; other site 767462004410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767462004411 nucleotide binding region [chemical binding]; other site 767462004412 ATP-binding site [chemical binding]; other site 767462004413 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 767462004414 active site 767462004415 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 767462004416 amino acid transporter; Region: 2A0306; TIGR00909 767462004417 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767462004418 active site 767462004419 Domain of unknown function DUF21; Region: DUF21; pfam01595 767462004420 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 767462004421 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 767462004422 Transporter associated domain; Region: CorC_HlyC; smart01091 767462004423 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 767462004424 HPr interaction site; other site 767462004425 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767462004426 active site 767462004427 phosphorylation site [posttranslational modification] 767462004428 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 767462004429 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 767462004430 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 767462004431 putative active site [active] 767462004432 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 767462004433 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767462004434 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767462004435 active site turn [active] 767462004436 phosphorylation site [posttranslational modification] 767462004437 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 767462004438 active site turn [active] 767462004439 phosphorylation site [posttranslational modification] 767462004440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462004441 active site 767462004442 motif I; other site 767462004443 motif II; other site 767462004444 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 767462004445 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 767462004446 active site 767462004447 nucleophile elbow; other site 767462004448 putative phosphoketolase; Provisional; Region: PRK05261 767462004449 XFP N-terminal domain; Region: XFP_N; pfam09364 767462004450 XFP C-terminal domain; Region: XFP_C; pfam09363 767462004451 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 767462004452 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 767462004453 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 767462004454 Enterocin A Immunity; Region: EntA_Immun; pfam08951 767462004455 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 767462004456 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 767462004457 FeS assembly protein SufB; Region: sufB; TIGR01980 767462004458 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 767462004459 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 767462004460 trimerization site [polypeptide binding]; other site 767462004461 active site 767462004462 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 767462004463 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 767462004464 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767462004465 catalytic residue [active] 767462004466 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 767462004467 FeS assembly protein SufD; Region: sufD; TIGR01981 767462004468 FeS assembly ATPase SufC; Region: sufC; TIGR01978 767462004469 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 767462004470 Walker A/P-loop; other site 767462004471 ATP binding site [chemical binding]; other site 767462004472 Q-loop/lid; other site 767462004473 ABC transporter signature motif; other site 767462004474 Walker B; other site 767462004475 D-loop; other site 767462004476 H-loop/switch region; other site 767462004477 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767462004478 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 767462004479 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767462004480 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 767462004481 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767462004482 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 767462004483 Helix-turn-helix domain; Region: HTH_19; pfam12844 767462004484 non-specific DNA binding site [nucleotide binding]; other site 767462004485 salt bridge; other site 767462004486 sequence-specific DNA binding site [nucleotide binding]; other site 767462004487 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767462004488 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 767462004489 DNA-binding site [nucleotide binding]; DNA binding site 767462004490 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 767462004491 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 767462004492 active site 767462004493 tetramer interface [polypeptide binding]; other site 767462004494 K+ potassium transporter; Region: K_trans; pfam02705 767462004495 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 767462004496 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767462004497 active site 767462004498 dimer interface [polypeptide binding]; other site 767462004499 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 767462004500 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 767462004501 substrate binding site [chemical binding]; other site 767462004502 dimer interface [polypeptide binding]; other site 767462004503 ATP binding site [chemical binding]; other site 767462004504 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 767462004505 nucleotide binding site/active site [active] 767462004506 HIT family signature motif; other site 767462004507 catalytic residue [active] 767462004508 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 767462004509 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 767462004510 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 767462004511 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 767462004512 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 767462004513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462004514 dimer interface [polypeptide binding]; other site 767462004515 conserved gate region; other site 767462004516 putative PBP binding loops; other site 767462004517 ABC-ATPase subunit interface; other site 767462004518 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 767462004519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462004520 dimer interface [polypeptide binding]; other site 767462004521 conserved gate region; other site 767462004522 putative PBP binding loops; other site 767462004523 ABC-ATPase subunit interface; other site 767462004524 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767462004525 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767462004526 substrate binding pocket [chemical binding]; other site 767462004527 membrane-bound complex binding site; other site 767462004528 hinge residues; other site 767462004529 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767462004530 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767462004531 Walker A/P-loop; other site 767462004532 ATP binding site [chemical binding]; other site 767462004533 Q-loop/lid; other site 767462004534 ABC transporter signature motif; other site 767462004535 Walker B; other site 767462004536 D-loop; other site 767462004537 H-loop/switch region; other site 767462004538 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767462004539 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 767462004540 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767462004541 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767462004542 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 767462004543 Walker A/P-loop; other site 767462004544 ATP binding site [chemical binding]; other site 767462004545 Q-loop/lid; other site 767462004546 ABC transporter signature motif; other site 767462004547 Walker B; other site 767462004548 D-loop; other site 767462004549 H-loop/switch region; other site 767462004550 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767462004551 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767462004552 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462004553 Walker A/P-loop; other site 767462004554 ATP binding site [chemical binding]; other site 767462004555 Q-loop/lid; other site 767462004556 ABC transporter signature motif; other site 767462004557 Walker B; other site 767462004558 D-loop; other site 767462004559 H-loop/switch region; other site 767462004560 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 767462004561 Transcriptional regulators [Transcription]; Region: MarR; COG1846 767462004562 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767462004563 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767462004564 substrate binding pocket [chemical binding]; other site 767462004565 membrane-bound complex binding site; other site 767462004566 hinge residues; other site 767462004567 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 767462004568 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 767462004569 catalytic triad [active] 767462004570 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 767462004571 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767462004572 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767462004573 ABC transporter; Region: ABC_tran_2; pfam12848 767462004574 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767462004575 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 767462004576 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 767462004577 oligomer interface [polypeptide binding]; other site 767462004578 active site 767462004579 metal binding site [ion binding]; metal-binding site 767462004580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767462004581 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767462004582 putative substrate translocation pore; other site 767462004583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767462004584 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 767462004585 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767462004586 active site 767462004587 uracil-xanthine permease; Region: ncs2; TIGR00801 767462004588 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767462004589 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767462004590 active site 767462004591 catalytic tetrad [active] 767462004592 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 767462004593 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 767462004594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767462004595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 767462004596 Coenzyme A binding pocket [chemical binding]; other site 767462004597 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767462004598 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767462004599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767462004600 putative substrate translocation pore; other site 767462004601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767462004602 Coenzyme A binding pocket [chemical binding]; other site 767462004603 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767462004604 MULE transposase domain; Region: MULE; pfam10551 767462004605 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 767462004606 DNA-binding site [nucleotide binding]; DNA binding site 767462004607 RNA-binding motif; other site 767462004608 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462004609 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462004610 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767462004611 Helix-turn-helix domain; Region: HTH_38; pfam13936 767462004612 Integrase core domain; Region: rve; pfam00665 767462004613 TRAM domain; Region: TRAM; cl01282 767462004614 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 767462004615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767462004616 S-adenosylmethionine binding site [chemical binding]; other site 767462004617 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 767462004618 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 767462004619 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 767462004620 putative lipid kinase; Reviewed; Region: PRK13337 767462004621 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 767462004622 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 767462004623 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 767462004624 GatB domain; Region: GatB_Yqey; pfam02637 767462004625 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 767462004626 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 767462004627 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 767462004628 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 767462004629 putative dimer interface [polypeptide binding]; other site 767462004630 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 767462004631 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 767462004632 putative dimer interface [polypeptide binding]; other site 767462004633 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 767462004634 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 767462004635 nucleotide binding pocket [chemical binding]; other site 767462004636 K-X-D-G motif; other site 767462004637 catalytic site [active] 767462004638 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 767462004639 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 767462004640 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 767462004641 Dimer interface [polypeptide binding]; other site 767462004642 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 767462004643 Part of AAA domain; Region: AAA_19; pfam13245 767462004644 Family description; Region: UvrD_C_2; pfam13538 767462004645 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 767462004646 SprT homologues; Region: SprT; cl01182 767462004647 hypothetical protein; Provisional; Region: PRK04351 767462004648 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 767462004649 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 767462004650 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 767462004651 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 767462004652 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 767462004653 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 767462004654 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 767462004655 homodimer interface [polypeptide binding]; other site 767462004656 NAD binding pocket [chemical binding]; other site 767462004657 ATP binding pocket [chemical binding]; other site 767462004658 Mg binding site [ion binding]; other site 767462004659 active-site loop [active] 767462004660 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 767462004661 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 767462004662 active site 767462004663 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767462004664 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 767462004665 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 767462004666 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 767462004667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462004668 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462004669 Probable transposase; Region: OrfB_IS605; pfam01385 767462004670 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462004671 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462004672 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767462004673 active site 767462004674 nucleotide binding site [chemical binding]; other site 767462004675 HIGH motif; other site 767462004676 KMSKS motif; other site 767462004677 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 767462004678 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767462004679 DNA-binding site [nucleotide binding]; DNA binding site 767462004680 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 767462004681 Bacterial surface layer protein; Region: SLAP; pfam03217 767462004682 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767462004683 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 767462004684 Integrase core domain; Region: rve; pfam00665 767462004685 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 767462004686 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 767462004687 active site 767462004688 catalytic site [active] 767462004689 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767462004690 catalytic core [active] 767462004691 Uncharacterized conserved protein [Function unknown]; Region: COG1359 767462004692 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767462004693 catalytic core [active] 767462004694 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 767462004695 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 767462004696 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767462004697 active site 767462004698 metal binding site [ion binding]; metal-binding site 767462004699 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 767462004700 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 767462004701 active site 767462004702 dimer interface [polypeptide binding]; other site 767462004703 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 767462004704 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767462004705 DNA-binding site [nucleotide binding]; DNA binding site 767462004706 UTRA domain; Region: UTRA; pfam07702 767462004707 TIGR02452 family protein; Region: TIGR02452 767462004708 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 767462004709 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 767462004710 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767462004711 ATP binding site [chemical binding]; other site 767462004712 putative Mg++ binding site [ion binding]; other site 767462004713 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767462004714 nucleotide binding region [chemical binding]; other site 767462004715 ATP-binding site [chemical binding]; other site 767462004716 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 767462004717 AAA ATPase domain; Region: AAA_16; pfam13191 767462004718 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 767462004719 active site 767462004720 metal-binding site [ion binding] 767462004721 nucleotide-binding site [chemical binding]; other site 767462004722 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 767462004723 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462004724 Probable transposase; Region: OrfB_IS605; pfam01385 767462004725 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462004726 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 767462004727 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 767462004728 DNA binding residues [nucleotide binding] 767462004729 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 767462004730 catalytic residues [active] 767462004731 catalytic nucleophile [active] 767462004732 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 767462004733 active site 767462004734 Ap4A binding cleft/pocket [chemical binding]; other site 767462004735 P4 phosphate binding site; other site 767462004736 nudix motif; other site 767462004737 putative P2/P3 phosphate binding site [ion binding]; other site 767462004738 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 767462004739 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 767462004740 propionate/acetate kinase; Provisional; Region: PRK12379 767462004741 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 767462004742 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 767462004743 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 767462004744 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 767462004745 glutaminase active site [active] 767462004746 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 767462004747 dimer interface [polypeptide binding]; other site 767462004748 active site 767462004749 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 767462004750 dimer interface [polypeptide binding]; other site 767462004751 active site 767462004752 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 767462004753 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 767462004754 putative catalytic cysteine [active] 767462004755 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 767462004756 putative active site [active] 767462004757 metal binding site [ion binding]; metal-binding site 767462004758 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 767462004759 putative trimer interface [polypeptide binding]; other site 767462004760 putative CoA binding site [chemical binding]; other site 767462004761 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767462004762 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767462004763 dimerization interface [polypeptide binding]; other site 767462004764 Domain of unknown function (DUF956); Region: DUF956; pfam06115 767462004765 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 767462004766 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 767462004767 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 767462004768 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 767462004769 active pocket/dimerization site; other site 767462004770 active site 767462004771 phosphorylation site [posttranslational modification] 767462004772 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 767462004773 active site 767462004774 phosphorylation site [posttranslational modification] 767462004775 Melibiase; Region: Melibiase; pfam02065 767462004776 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 767462004777 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 767462004778 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 767462004779 substrate binding [chemical binding]; other site 767462004780 active site 767462004781 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 767462004782 seryl-tRNA synthetase; Provisional; Region: PRK05431 767462004783 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 767462004784 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 767462004785 dimer interface [polypeptide binding]; other site 767462004786 active site 767462004787 motif 1; other site 767462004788 motif 2; other site 767462004789 motif 3; other site 767462004790 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 767462004791 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 767462004792 Uncharacterized conserved protein [Function unknown]; Region: COG0398 767462004793 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 767462004794 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 767462004795 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 767462004796 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 767462004797 NAD(P) binding site [chemical binding]; other site 767462004798 catalytic residues [active] 767462004799 Double zinc ribbon; Region: DZR; pfam12773 767462004800 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 767462004801 MMPL family; Region: MMPL; pfam03176 767462004802 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 767462004803 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 767462004804 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 767462004805 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 767462004806 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 767462004807 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767462004808 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767462004809 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 767462004810 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 767462004811 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 767462004812 oligomer interface [polypeptide binding]; other site 767462004813 Cl binding site [ion binding]; other site 767462004814 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 767462004815 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 767462004816 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 767462004817 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 767462004818 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 767462004819 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 767462004820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462004821 dimer interface [polypeptide binding]; other site 767462004822 conserved gate region; other site 767462004823 ABC-ATPase subunit interface; other site 767462004824 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 767462004825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462004826 dimer interface [polypeptide binding]; other site 767462004827 conserved gate region; other site 767462004828 putative PBP binding loops; other site 767462004829 ABC-ATPase subunit interface; other site 767462004830 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 767462004831 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 767462004832 Walker A/P-loop; other site 767462004833 ATP binding site [chemical binding]; other site 767462004834 Q-loop/lid; other site 767462004835 ABC transporter signature motif; other site 767462004836 Walker B; other site 767462004837 D-loop; other site 767462004838 H-loop/switch region; other site 767462004839 TOBE domain; Region: TOBE_2; pfam08402 767462004840 Peptidase family C69; Region: Peptidase_C69; pfam03577 767462004841 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 767462004842 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 767462004843 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 767462004844 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 767462004845 active site 767462004846 catalytic site [active] 767462004847 substrate binding site [chemical binding]; other site 767462004848 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 767462004849 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 767462004850 Resolvase, N terminal domain; Region: Resolvase; pfam00239 767462004851 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 767462004852 Integrase core domain; Region: rve; pfam00665 767462004853 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 767462004854 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 767462004855 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 767462004856 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 767462004857 Presynaptic Site I dimer interface [polypeptide binding]; other site 767462004858 catalytic residues [active] 767462004859 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 767462004860 Synaptic Flat tetramer interface [polypeptide binding]; other site 767462004861 Synaptic Site I dimer interface [polypeptide binding]; other site 767462004862 DNA binding site [nucleotide binding] 767462004863 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462004864 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462004865 (R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184 767462004866 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 767462004867 putative homodimer interface [polypeptide binding]; other site 767462004868 putative ligand binding site [chemical binding]; other site 767462004869 putative NAD binding site [chemical binding]; other site 767462004870 catalytic site [active] 767462004871 putative transposase OrfB; Reviewed; Region: PHA02517 767462004872 HTH-like domain; Region: HTH_21; pfam13276 767462004873 Integrase core domain; Region: rve; pfam00665 767462004874 Integrase core domain; Region: rve_3; pfam13683 767462004875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767462004876 Transposase; Region: HTH_Tnp_1; pfam01527 767462004877 RelB antitoxin; Region: RelB; cl01171 767462004878 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 767462004879 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 767462004880 Probable transposase; Region: OrfB_IS605; pfam01385 767462004881 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462004882 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767462004883 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 767462004884 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462004885 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462004886 Probable transposase; Region: OrfB_IS605; pfam01385 767462004887 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462004888 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462004889 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767462004890 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767462004891 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 767462004892 Walker A/P-loop; other site 767462004893 ATP binding site [chemical binding]; other site 767462004894 Q-loop/lid; other site 767462004895 ABC transporter signature motif; other site 767462004896 Walker B; other site 767462004897 D-loop; other site 767462004898 H-loop/switch region; other site 767462004899 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 767462004900 adenosine deaminase; Provisional; Region: PRK09358 767462004901 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 767462004902 active site 767462004903 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 767462004904 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 767462004905 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 767462004906 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 767462004907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767462004908 Coenzyme A binding pocket [chemical binding]; other site 767462004909 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767462004910 MarR family; Region: MarR; pfam01047 767462004911 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 767462004912 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 767462004913 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 767462004914 elongation factor P; Validated; Region: PRK00529 767462004915 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 767462004916 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 767462004917 RNA binding site [nucleotide binding]; other site 767462004918 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 767462004919 RNA binding site [nucleotide binding]; other site 767462004920 pantothenate kinase; Provisional; Region: PRK05439 767462004921 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 767462004922 ATP-binding site [chemical binding]; other site 767462004923 CoA-binding site [chemical binding]; other site 767462004924 Mg2+-binding site [ion binding]; other site 767462004925 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 767462004926 active site 767462004927 catalytic triad [active] 767462004928 oxyanion hole [active] 767462004929 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462004930 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462004931 Probable transposase; Region: OrfB_IS605; pfam01385 767462004932 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462004933 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462004934 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 767462004935 Part of AAA domain; Region: AAA_19; pfam13245 767462004936 Family description; Region: UvrD_C_2; pfam13538 767462004937 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 767462004938 active site 767462004939 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767462004940 catalytic core [active] 767462004941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462004942 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462004943 Probable transposase; Region: OrfB_IS605; pfam01385 767462004944 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462004945 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462004946 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 767462004947 aspartate racemase; Region: asp_race; TIGR00035 767462004948 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 767462004949 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 767462004950 TrkA-C domain; Region: TrkA_C; pfam02080 767462004951 Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293 767462004952 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 767462004953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767462004954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767462004955 homodimer interface [polypeptide binding]; other site 767462004956 catalytic residue [active] 767462004957 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767462004958 Integrase core domain; Region: rve; pfam00665 767462004959 Asp23 family; Region: Asp23; pfam03780 767462004960 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 767462004961 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462004962 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462004963 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767462004964 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767462004965 Walker A/P-loop; other site 767462004966 ATP binding site [chemical binding]; other site 767462004967 Q-loop/lid; other site 767462004968 ABC transporter signature motif; other site 767462004969 Walker B; other site 767462004970 D-loop; other site 767462004971 H-loop/switch region; other site 767462004972 Predicted membrane protein [Function unknown]; Region: COG4640 767462004973 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 767462004974 active site 767462004975 homodimer interface [polypeptide binding]; other site 767462004976 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 767462004977 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 767462004978 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 767462004979 putative active site [active] 767462004980 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 767462004981 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 767462004982 NAD binding site [chemical binding]; other site 767462004983 sugar binding site [chemical binding]; other site 767462004984 divalent metal binding site [ion binding]; other site 767462004985 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 767462004986 dimer interface [polypeptide binding]; other site 767462004987 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767462004988 Helix-turn-helix domain; Region: HTH_38; pfam13936 767462004989 Integrase core domain; Region: rve; pfam00665 767462004990 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767462004991 Coenzyme A binding pocket [chemical binding]; other site 767462004992 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767462004993 Beta-lactamase; Region: Beta-lactamase; pfam00144 767462004994 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 767462004995 Probable transposase; Region: OrfB_IS605; pfam01385 767462004996 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462004997 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767462004998 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 767462004999 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 767462005000 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 767462005001 active site 767462005002 tetramer interface; other site 767462005003 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 767462005004 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 767462005005 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767462005006 catalytic residue [active] 767462005007 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 767462005008 Amino acid permease; Region: AA_permease_2; pfam13520 767462005009 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767462005010 MULE transposase domain; Region: MULE; pfam10551 767462005011 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 767462005012 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767462005013 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 767462005014 Integrase core domain; Region: rve; pfam00665 767462005015 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 767462005016 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 767462005017 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767462005018 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 767462005019 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767462005020 active site 767462005021 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 767462005022 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 767462005023 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767462005024 putative ADP-binding pocket [chemical binding]; other site 767462005025 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 767462005026 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 767462005027 putative ADP-binding pocket [chemical binding]; other site 767462005028 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 767462005029 Bacterial sugar transferase; Region: Bac_transf; pfam02397 767462005030 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 767462005031 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767462005032 active site 767462005033 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 767462005034 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 767462005035 Nucleotide binding site [chemical binding]; other site 767462005036 DTAP/Switch II; other site 767462005037 Switch I; other site 767462005038 Chain length determinant protein; Region: Wzz; cl15801 767462005039 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 767462005040 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 767462005041 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 767462005042 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 767462005043 HflX GTPase family; Region: HflX; cd01878 767462005044 G1 box; other site 767462005045 GTP/Mg2+ binding site [chemical binding]; other site 767462005046 Switch I region; other site 767462005047 G2 box; other site 767462005048 G3 box; other site 767462005049 Switch II region; other site 767462005050 G4 box; other site 767462005051 G5 box; other site 767462005052 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 767462005053 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767462005054 NlpC/P60 family; Region: NLPC_P60; pfam00877 767462005055 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767462005056 NlpC/P60 family; Region: NLPC_P60; pfam00877 767462005057 Archaeal ATPase; Region: Arch_ATPase; pfam01637 767462005058 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767462005059 NlpC/P60 family; Region: NLPC_P60; pfam00877 767462005060 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 767462005061 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 767462005062 catalytic site [active] 767462005063 G-X2-G-X-G-K; other site 767462005064 MFS/sugar transport protein; Region: MFS_2; pfam13347 767462005065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462005066 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462005067 Probable transposase; Region: OrfB_IS605; pfam01385 767462005068 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462005069 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462005070 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 767462005071 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 767462005072 Probable transposase; Region: OrfB_IS605; pfam01385 767462005073 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462005074 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767462005075 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 767462005076 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 767462005077 Uncharacterized conserved protein [Function unknown]; Region: COG2966 767462005078 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 767462005079 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 767462005080 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767462005081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462005082 Walker A/P-loop; other site 767462005083 ATP binding site [chemical binding]; other site 767462005084 Q-loop/lid; other site 767462005085 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767462005086 ABC transporter signature motif; other site 767462005087 Walker B; other site 767462005088 D-loop; other site 767462005089 ABC transporter; Region: ABC_tran_2; pfam12848 767462005090 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767462005091 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 767462005092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 767462005093 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 767462005094 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 767462005095 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 767462005096 active site 767462005097 Zn binding site [ion binding]; other site 767462005098 Enterocin A Immunity; Region: EntA_Immun; pfam08951 767462005099 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462005100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462005101 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 767462005102 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 767462005103 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 767462005104 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 767462005105 dimer interface [polypeptide binding]; other site 767462005106 putative PBP binding regions; other site 767462005107 ABC-ATPase subunit interface; other site 767462005108 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767462005109 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 767462005110 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 767462005111 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 767462005112 intersubunit interface [polypeptide binding]; other site 767462005113 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767462005114 dimerization interface [polypeptide binding]; other site 767462005115 putative DNA binding site [nucleotide binding]; other site 767462005116 putative Zn2+ binding site [ion binding]; other site 767462005117 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462005118 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462005119 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 767462005120 AAA ATPase domain; Region: AAA_16; pfam13191 767462005121 AAA domain; Region: AAA_14; pfam13173 767462005122 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 767462005123 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 767462005124 aspartate racemase; Region: asp_race; TIGR00035 767462005125 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 767462005126 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767462005127 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767462005128 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767462005129 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767462005130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767462005131 dimer interface [polypeptide binding]; other site 767462005132 phosphorylation site [posttranslational modification] 767462005133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767462005134 ATP binding site [chemical binding]; other site 767462005135 Mg2+ binding site [ion binding]; other site 767462005136 G-X-G motif; other site 767462005137 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767462005138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767462005139 active site 767462005140 phosphorylation site [posttranslational modification] 767462005141 intermolecular recognition site; other site 767462005142 dimerization interface [polypeptide binding]; other site 767462005143 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767462005144 DNA binding site [nucleotide binding] 767462005145 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767462005146 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767462005147 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 767462005148 Walker A/P-loop; other site 767462005149 ATP binding site [chemical binding]; other site 767462005150 Q-loop/lid; other site 767462005151 ABC transporter signature motif; other site 767462005152 Walker B; other site 767462005153 D-loop; other site 767462005154 H-loop/switch region; other site 767462005155 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767462005156 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767462005157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462005158 Walker A/P-loop; other site 767462005159 ATP binding site [chemical binding]; other site 767462005160 Q-loop/lid; other site 767462005161 ABC transporter signature motif; other site 767462005162 Walker B; other site 767462005163 D-loop; other site 767462005164 H-loop/switch region; other site 767462005165 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 767462005166 GTP-binding protein YchF; Reviewed; Region: PRK09601 767462005167 YchF GTPase; Region: YchF; cd01900 767462005168 G1 box; other site 767462005169 GTP/Mg2+ binding site [chemical binding]; other site 767462005170 Switch I region; other site 767462005171 G2 box; other site 767462005172 Switch II region; other site 767462005173 G3 box; other site 767462005174 G4 box; other site 767462005175 G5 box; other site 767462005176 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 767462005177 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 767462005178 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 767462005179 ParB-like nuclease domain; Region: ParB; smart00470 767462005180 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 767462005181 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767462005182 P-loop; other site 767462005183 Magnesium ion binding site [ion binding]; other site 767462005184 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767462005185 Magnesium ion binding site [ion binding]; other site 767462005186 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 767462005187 ParB-like nuclease domain; Region: ParB; smart00470 767462005188 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 767462005189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767462005190 S-adenosylmethionine binding site [chemical binding]; other site 767462005191 Colicin V production protein; Region: Colicin_V; pfam02674 767462005192 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 767462005193 ApbE family; Region: ApbE; pfam02424 767462005194 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 767462005195 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 767462005196 Predicted flavoprotein [General function prediction only]; Region: COG0431 767462005197 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767462005198 Predicted flavoprotein [General function prediction only]; Region: COG0431 767462005199 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767462005200 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767462005201 WHG domain; Region: WHG; pfam13305 767462005202 Peptidase family C69; Region: Peptidase_C69; pfam03577 767462005203 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767462005204 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767462005205 Walker A/P-loop; other site 767462005206 ATP binding site [chemical binding]; other site 767462005207 Q-loop/lid; other site 767462005208 ABC transporter signature motif; other site 767462005209 Walker B; other site 767462005210 D-loop; other site 767462005211 H-loop/switch region; other site 767462005212 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767462005213 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 767462005214 FtsX-like permease family; Region: FtsX; pfam02687 767462005215 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767462005216 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767462005217 catalytic core [active] 767462005218 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 767462005219 hypothetical protein; Validated; Region: PRK02101 767462005220 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462005221 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462005222 Probable transposase; Region: OrfB_IS605; pfam01385 767462005223 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462005224 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462005225 Enterocin A Immunity; Region: EntA_Immun; pfam08951 767462005226 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767462005227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767462005228 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767462005229 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 767462005230 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 767462005231 putative substrate binding site [chemical binding]; other site 767462005232 putative ATP binding site [chemical binding]; other site 767462005233 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 767462005234 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 767462005235 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 767462005236 RelB antitoxin; Region: RelB; cl01171 767462005237 RelB antitoxin; Region: RelB; cl01171 767462005238 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 767462005239 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 767462005240 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 767462005241 trimer interface [polypeptide binding]; other site 767462005242 active site 767462005243 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 767462005244 catalytic site [active] 767462005245 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462005246 salt bridge; other site 767462005247 non-specific DNA binding site [nucleotide binding]; other site 767462005248 sequence-specific DNA binding site [nucleotide binding]; other site 767462005249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462005250 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462005251 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 767462005252 AAA ATPase domain; Region: AAA_16; pfam13191 767462005253 AAA domain; Region: AAA_14; pfam13173 767462005254 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 767462005255 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 767462005256 aspartate racemase; Region: asp_race; TIGR00035 767462005257 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 767462005258 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767462005259 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767462005260 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767462005261 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767462005262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767462005263 dimer interface [polypeptide binding]; other site 767462005264 phosphorylation site [posttranslational modification] 767462005265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767462005266 ATP binding site [chemical binding]; other site 767462005267 Mg2+ binding site [ion binding]; other site 767462005268 G-X-G motif; other site 767462005269 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767462005270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767462005271 active site 767462005272 phosphorylation site [posttranslational modification] 767462005273 intermolecular recognition site; other site 767462005274 dimerization interface [polypeptide binding]; other site 767462005275 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767462005276 DNA binding site [nucleotide binding] 767462005277 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767462005278 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767462005279 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 767462005280 Walker A/P-loop; other site 767462005281 ATP binding site [chemical binding]; other site 767462005282 Q-loop/lid; other site 767462005283 ABC transporter signature motif; other site 767462005284 Walker B; other site 767462005285 D-loop; other site 767462005286 H-loop/switch region; other site 767462005287 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767462005288 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767462005289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462005290 Walker A/P-loop; other site 767462005291 ATP binding site [chemical binding]; other site 767462005292 Q-loop/lid; other site 767462005293 ABC transporter signature motif; other site 767462005294 Walker B; other site 767462005295 D-loop; other site 767462005296 H-loop/switch region; other site 767462005297 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 767462005298 GTP-binding protein YchF; Reviewed; Region: PRK09601 767462005299 YchF GTPase; Region: YchF; cd01900 767462005300 G1 box; other site 767462005301 GTP/Mg2+ binding site [chemical binding]; other site 767462005302 Switch I region; other site 767462005303 G2 box; other site 767462005304 Switch II region; other site 767462005305 G3 box; other site 767462005306 G4 box; other site 767462005307 G5 box; other site 767462005308 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 767462005309 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 767462005310 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 767462005311 ParB-like nuclease domain; Region: ParB; smart00470 767462005312 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 767462005313 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767462005314 P-loop; other site 767462005315 Magnesium ion binding site [ion binding]; other site 767462005316 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767462005317 Magnesium ion binding site [ion binding]; other site 767462005318 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 767462005319 ParB-like nuclease domain; Region: ParB; smart00470 767462005320 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 767462005321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767462005322 S-adenosylmethionine binding site [chemical binding]; other site 767462005323 Colicin V production protein; Region: Colicin_V; pfam02674 767462005324 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 767462005325 ApbE family; Region: ApbE; pfam02424 767462005326 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 767462005327 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 767462005328 Predicted flavoprotein [General function prediction only]; Region: COG0431 767462005329 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767462005330 Predicted flavoprotein [General function prediction only]; Region: COG0431 767462005331 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767462005332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767462005333 WHG domain; Region: WHG; pfam13305 767462005334 Peptidase family C69; Region: Peptidase_C69; pfam03577 767462005335 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767462005336 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767462005337 Walker A/P-loop; other site 767462005338 ATP binding site [chemical binding]; other site 767462005339 Q-loop/lid; other site 767462005340 ABC transporter signature motif; other site 767462005341 Walker B; other site 767462005342 D-loop; other site 767462005343 H-loop/switch region; other site 767462005344 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767462005345 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 767462005346 FtsX-like permease family; Region: FtsX; pfam02687 767462005347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767462005348 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767462005349 catalytic core [active] 767462005350 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 767462005351 hypothetical protein; Validated; Region: PRK02101 767462005352 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462005353 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462005354 Probable transposase; Region: OrfB_IS605; pfam01385 767462005355 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462005356 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462005357 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 767462005358 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 767462005359 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 767462005360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767462005361 putative substrate translocation pore; other site 767462005362 POT family; Region: PTR2; cl17359 767462005363 Peptidase family M1; Region: Peptidase_M1; pfam01433 767462005364 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 767462005365 Zn binding site [ion binding]; other site 767462005366 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 767462005367 drug efflux system protein MdtG; Provisional; Region: PRK09874 767462005368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767462005369 putative substrate translocation pore; other site 767462005370 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 767462005371 H+ Antiporter protein; Region: 2A0121; TIGR00900 767462005372 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767462005373 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462005374 non-specific DNA binding site [nucleotide binding]; other site 767462005375 salt bridge; other site 767462005376 sequence-specific DNA binding site [nucleotide binding]; other site 767462005377 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 767462005378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462005379 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462005380 Probable transposase; Region: OrfB_IS605; pfam01385 767462005381 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462005382 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462005383 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 767462005384 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767462005385 MULE transposase domain; Region: MULE; pfam10551 767462005386 Enterocin A Immunity; Region: EntA_Immun; pfam08951 767462005387 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 767462005388 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 767462005389 Class I ribonucleotide reductase; Region: RNR_I; cd01679 767462005390 active site 767462005391 dimer interface [polypeptide binding]; other site 767462005392 catalytic residues [active] 767462005393 effector binding site; other site 767462005394 R2 peptide binding site; other site 767462005395 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 767462005396 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 767462005397 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 767462005398 dimer interface [polypeptide binding]; other site 767462005399 putative radical transfer pathway; other site 767462005400 diiron center [ion binding]; other site 767462005401 tyrosyl radical; other site 767462005402 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 767462005403 S-ribosylhomocysteinase; Provisional; Region: PRK02260 767462005404 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 767462005405 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 767462005406 THF binding site; other site 767462005407 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 767462005408 substrate binding site [chemical binding]; other site 767462005409 THF binding site; other site 767462005410 zinc-binding site [ion binding]; other site 767462005411 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 767462005412 FAD binding site [chemical binding]; other site 767462005413 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462005414 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462005415 Probable transposase; Region: OrfB_IS605; pfam01385 767462005416 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462005417 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462005418 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767462005419 Helix-turn-helix domain; Region: HTH_38; pfam13936 767462005420 Integrase core domain; Region: rve; pfam00665 767462005421 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 767462005422 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767462005423 active site 767462005424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462005425 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462005426 BioY family; Region: BioY; pfam02632 767462005427 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 767462005428 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767462005429 putative DNA binding site [nucleotide binding]; other site 767462005430 putative Zn2+ binding site [ion binding]; other site 767462005431 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 767462005432 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 767462005433 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 767462005434 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 767462005435 NAD binding site [chemical binding]; other site 767462005436 homotetramer interface [polypeptide binding]; other site 767462005437 homodimer interface [polypeptide binding]; other site 767462005438 substrate binding site [chemical binding]; other site 767462005439 active site 767462005440 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 767462005441 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 767462005442 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 767462005443 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 767462005444 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767462005445 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767462005446 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 767462005447 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 767462005448 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 767462005449 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 767462005450 carboxyltransferase (CT) interaction site; other site 767462005451 biotinylation site [posttranslational modification]; other site 767462005452 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 767462005453 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 767462005454 dimer interface [polypeptide binding]; other site 767462005455 active site 767462005456 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 767462005457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767462005458 NAD(P) binding site [chemical binding]; other site 767462005459 active site 767462005460 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 767462005461 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 767462005462 acyl carrier protein; Provisional; Region: acpP; PRK00982 767462005463 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 767462005464 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 767462005465 dimer interface [polypeptide binding]; other site 767462005466 active site 767462005467 CoA binding pocket [chemical binding]; other site 767462005468 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767462005469 MarR family; Region: MarR_2; pfam12802 767462005470 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 767462005471 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 767462005472 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767462005473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767462005474 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767462005475 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 767462005476 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 767462005477 Presynaptic Site I dimer interface [polypeptide binding]; other site 767462005478 catalytic residues [active] 767462005479 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 767462005480 Synaptic Flat tetramer interface [polypeptide binding]; other site 767462005481 Synaptic Site I dimer interface [polypeptide binding]; other site 767462005482 DNA binding site [nucleotide binding] 767462005483 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462005484 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462005485 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 767462005486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462005487 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462005488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462005489 Walker A/P-loop; other site 767462005490 ATP binding site [chemical binding]; other site 767462005491 Q-loop/lid; other site 767462005492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462005493 ABC transporter signature motif; other site 767462005494 Walker B; other site 767462005495 D-loop; other site 767462005496 H-loop/switch region; other site 767462005497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462005498 AAA domain; Region: AAA_21; pfam13304 767462005499 Walker A/P-loop; other site 767462005500 ATP binding site [chemical binding]; other site 767462005501 Q-loop/lid; other site 767462005502 ABC transporter signature motif; other site 767462005503 Walker B; other site 767462005504 D-loop; other site 767462005505 H-loop/switch region; other site 767462005506 Integrase core domain; Region: rve; pfam00665 767462005507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767462005508 Helix-turn-helix domain; Region: HTH_28; pfam13518 767462005509 Helix-turn-helix domain; Region: HTH_28; pfam13518 767462005510 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 767462005511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767462005512 putative substrate translocation pore; other site 767462005513 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767462005514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767462005515 benzoate transport; Region: 2A0115; TIGR00895 767462005516 putative substrate translocation pore; other site 767462005517 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 767462005518 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 767462005519 dimerization interface [polypeptide binding]; other site 767462005520 active site 767462005521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462005522 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462005523 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767462005524 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462005525 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767462005526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767462005527 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767462005528 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 767462005529 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767462005530 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767462005531 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767462005532 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 767462005533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462005534 dimer interface [polypeptide binding]; other site 767462005535 conserved gate region; other site 767462005536 putative PBP binding loops; other site 767462005537 ABC-ATPase subunit interface; other site 767462005538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767462005539 dimer interface [polypeptide binding]; other site 767462005540 conserved gate region; other site 767462005541 ABC-ATPase subunit interface; other site 767462005542 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 767462005543 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 767462005544 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 767462005545 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 767462005546 Walker A/P-loop; other site 767462005547 ATP binding site [chemical binding]; other site 767462005548 Q-loop/lid; other site 767462005549 ABC transporter signature motif; other site 767462005550 Walker B; other site 767462005551 D-loop; other site 767462005552 H-loop/switch region; other site 767462005553 TOBE domain; Region: TOBE_2; pfam08402 767462005554 beta-phosphoglucomutase; Region: bPGM; TIGR01990 767462005555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767462005556 motif II; other site 767462005557 maltose phosphorylase; Provisional; Region: PRK13807 767462005558 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 767462005559 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 767462005560 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 767462005561 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 767462005562 homodimer interface [polypeptide binding]; other site 767462005563 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 767462005564 active site 767462005565 homodimer interface [polypeptide binding]; other site 767462005566 catalytic site [active] 767462005567 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 767462005568 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 767462005569 Ca binding site [ion binding]; other site 767462005570 active site 767462005571 catalytic site [active] 767462005572 Acetokinase family; Region: Acetate_kinase; cl17229 767462005573 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 767462005574 Probable transposase; Region: OrfB_IS605; pfam01385 767462005575 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462005576 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767462005577 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 767462005578 Acetokinase family; Region: Acetate_kinase; cl17229 767462005579 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767462005580 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767462005581 DNA binding site [nucleotide binding] 767462005582 domain linker motif; other site 767462005583 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 767462005584 ligand binding site [chemical binding]; other site 767462005585 dimerization interface [polypeptide binding]; other site 767462005586 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 767462005587 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 767462005588 glycerol kinase; Provisional; Region: glpK; PRK00047 767462005589 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 767462005590 N- and C-terminal domain interface [polypeptide binding]; other site 767462005591 active site 767462005592 MgATP binding site [chemical binding]; other site 767462005593 catalytic site [active] 767462005594 metal binding site [ion binding]; metal-binding site 767462005595 glycerol binding site [chemical binding]; other site 767462005596 homotetramer interface [polypeptide binding]; other site 767462005597 homodimer interface [polypeptide binding]; other site 767462005598 FBP binding site [chemical binding]; other site 767462005599 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 767462005600 dimer interface [polypeptide binding]; other site 767462005601 substrate binding site [chemical binding]; other site 767462005602 ATP binding site [chemical binding]; other site 767462005603 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 767462005604 catalytic triad [active] 767462005605 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767462005606 NlpC/P60 family; Region: NLPC_P60; pfam00877 767462005607 EamA-like transporter family; Region: EamA; pfam00892 767462005608 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 767462005609 EamA-like transporter family; Region: EamA; pfam00892 767462005610 Uncharacterized conserved protein [Function unknown]; Region: COG1434 767462005611 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 767462005612 putative active site [active] 767462005613 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767462005614 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767462005615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767462005616 Walker A/P-loop; other site 767462005617 ATP binding site [chemical binding]; other site 767462005618 adenylosuccinate lyase; Provisional; Region: PRK07492 767462005619 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 767462005620 tetramer interface [polypeptide binding]; other site 767462005621 active site 767462005622 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 767462005623 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 767462005624 IMP binding site; other site 767462005625 GDP-binding site [chemical binding]; other site 767462005626 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 767462005627 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 767462005628 active site 767462005629 Uncharacterized conserved protein [Function unknown]; Region: COG3589 767462005630 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 767462005631 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 767462005632 dimer interface [polypeptide binding]; other site 767462005633 active site 767462005634 putative transport protein YifK; Provisional; Region: PRK10746 767462005635 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 767462005636 cAMP-dependent protein kinase catalytic subunit; Provisional; Region: PTZ00426 767462005637 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 767462005638 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 767462005639 Catalytic site [active] 767462005640 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 767462005641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767462005642 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767462005643 Walker A motif; other site 767462005644 ATP binding site [chemical binding]; other site 767462005645 Walker B motif; other site 767462005646 arginine finger; other site 767462005647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767462005648 Walker A motif; other site 767462005649 ATP binding site [chemical binding]; other site 767462005650 Walker B motif; other site 767462005651 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 767462005652 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767462005653 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 767462005654 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767462005655 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767462005656 Walker A/P-loop; other site 767462005657 ATP binding site [chemical binding]; other site 767462005658 Q-loop/lid; other site 767462005659 ABC transporter signature motif; other site 767462005660 Walker B; other site 767462005661 D-loop; other site 767462005662 H-loop/switch region; other site 767462005663 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 767462005664 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 767462005665 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 767462005666 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 767462005667 active site 767462005668 Protein of unknown function (DUF975); Region: DUF975; cl10504 767462005669 CAAX protease self-immunity; Region: Abi; pfam02517 767462005670 Beta-lactamase; Region: Beta-lactamase; pfam00144 767462005671 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767462005672 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 767462005673 DltD N-terminal region; Region: DltD_N; pfam04915 767462005674 DltD central region; Region: DltD_M; pfam04918 767462005675 DltD C-terminal region; Region: DltD_C; pfam04914 767462005676 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 767462005677 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 767462005678 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 767462005679 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 767462005680 acyl-activating enzyme (AAE) consensus motif; other site 767462005681 AMP binding site [chemical binding]; other site 767462005682 Uncharacterized conserved protein [Function unknown]; Region: COG3391 767462005683 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 767462005684 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462005685 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462005686 Probable transposase; Region: OrfB_IS605; pfam01385 767462005687 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462005688 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462005689 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 767462005690 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 767462005691 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767462005692 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767462005693 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 767462005694 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 767462005695 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 767462005696 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 767462005697 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767462005698 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767462005699 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 767462005700 Walker A/P-loop; other site 767462005701 ATP binding site [chemical binding]; other site 767462005702 Q-loop/lid; other site 767462005703 ABC transporter signature motif; other site 767462005704 Walker B; other site 767462005705 D-loop; other site 767462005706 H-loop/switch region; other site 767462005707 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 767462005708 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 767462005709 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462005710 salt bridge; other site 767462005711 non-specific DNA binding site [nucleotide binding]; other site 767462005712 sequence-specific DNA binding site [nucleotide binding]; other site 767462005713 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 767462005714 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462005715 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462005716 Probable transposase; Region: OrfB_IS605; pfam01385 767462005717 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462005718 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462005719 CAAX protease self-immunity; Region: Abi; pfam02517 767462005720 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 767462005721 putative active site [active] 767462005722 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767462005723 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767462005724 Walker A/P-loop; other site 767462005725 ATP binding site [chemical binding]; other site 767462005726 Q-loop/lid; other site 767462005727 ABC transporter signature motif; other site 767462005728 Walker B; other site 767462005729 D-loop; other site 767462005730 H-loop/switch region; other site 767462005731 FtsX-like permease family; Region: FtsX; pfam02687 767462005732 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 767462005733 Predicted membrane protein [Function unknown]; Region: COG4684 767462005734 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767462005735 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767462005736 active site 767462005737 catalytic tetrad [active] 767462005738 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 767462005739 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 767462005740 active site 767462005741 trimer interface [polypeptide binding]; other site 767462005742 allosteric site; other site 767462005743 active site lid [active] 767462005744 hexamer (dimer of trimers) interface [polypeptide binding]; other site 767462005745 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 767462005746 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 767462005747 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 767462005748 putative active site [active] 767462005749 Uncharacterized conserved protein [Function unknown]; Region: COG3589 767462005750 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 767462005751 Beta-lactamase; Region: Beta-lactamase; cl17358 767462005752 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767462005753 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 767462005754 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 767462005755 putative active site [active] 767462005756 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 767462005757 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767462005758 active site turn [active] 767462005759 phosphorylation site [posttranslational modification] 767462005760 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767462005761 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 767462005762 HPr interaction site; other site 767462005763 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767462005764 active site 767462005765 phosphorylation site [posttranslational modification] 767462005766 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 767462005767 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 767462005768 Substrate-binding site [chemical binding]; other site 767462005769 Substrate specificity [chemical binding]; other site 767462005770 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 767462005771 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 767462005772 Substrate-binding site [chemical binding]; other site 767462005773 Substrate specificity [chemical binding]; other site 767462005774 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 767462005775 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767462005776 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767462005777 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767462005778 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 767462005779 AAA domain; Region: AAA_14; pfam13173 767462005780 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 767462005781 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767462005782 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767462005783 Probable transposase; Region: OrfB_IS605; pfam01385 767462005784 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767462005785 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 767462005786 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 767462005787 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 767462005788 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 767462005789 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 767462005790 Penicillinase repressor; Region: Pencillinase_R; pfam03965 767462005791 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 767462005792 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 767462005793 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 767462005794 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767462005795 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767462005796 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 767462005797 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 767462005798 Cl- selectivity filter; other site 767462005799 Cl- binding residues [ion binding]; other site 767462005800 pore gating glutamate residue; other site 767462005801 dimer interface [polypeptide binding]; other site 767462005802 H+/Cl- coupling transport residue; other site 767462005803 TrkA-C domain; Region: TrkA_C; pfam02080 767462005804 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 767462005805 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 767462005806 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 767462005807 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 767462005808 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 767462005809 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 767462005810 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 767462005811 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 767462005812 trmE is a tRNA modification GTPase; Region: trmE; cd04164 767462005813 G1 box; other site 767462005814 GTP/Mg2+ binding site [chemical binding]; other site 767462005815 Switch I region; other site 767462005816 G2 box; other site 767462005817 Switch II region; other site 767462005818 G3 box; other site 767462005819 G4 box; other site 767462005820 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 767462005821 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 767462005822 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 767462005823 ribonuclease P; Reviewed; Region: rnpA; PRK00499 767462005824 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 767462005825 Predicted membrane protein [Function unknown]; Region: COG2261 767462005826 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 767462005827 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 767462005828 catalytic residues [active] 767462005829 catalytic nucleophile [active] 767462005830 Presynaptic Site I dimer interface [polypeptide binding]; other site 767462005831 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 767462005832 Synaptic Flat tetramer interface [polypeptide binding]; other site 767462005833 Synaptic Site I dimer interface [polypeptide binding]; other site 767462005834 DNA binding site [nucleotide binding] 767462005835 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 767462005836 DNA-binding interface [nucleotide binding]; DNA binding site 767462005837 DNA polymerase IV; Reviewed; Region: PRK03103 767462005838 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 767462005839 active site 767462005840 DNA binding site [nucleotide binding] 767462005841 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 767462005842 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 767462005843 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 767462005844 putative ligand binding site [chemical binding]; other site 767462005845 putative NAD binding site [chemical binding]; other site 767462005846 catalytic site [active] 767462005847 Domain of unknown function (DUF955); Region: DUF955; cl01076 767462005848 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 767462005849 phosphate binding site [ion binding]; other site 767462005850 domain II; other site 767462005851 domain III; other site 767462005852 nucleotide binding site [chemical binding]; other site 767462005853 DNA binding groove [nucleotide binding] 767462005854 catalytic site [active] 767462005855 domain IV; other site 767462005856 MobA/MobL family; Region: MobA_MobL; pfam03389 767462005857 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 767462005858 Fic family protein [Function unknown]; Region: COG3177 767462005859 Fic/DOC family; Region: Fic; pfam02661 767462005860 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 767462005861 plasmid segregation protein ParM; Provisional; Region: PRK13917 767462005862 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 767462005863 Mg binding site [ion binding]; other site 767462005864 nucleotide binding site [chemical binding]; other site 767462005865 putative protofilament interface [polypeptide binding]; other site 767462005866 H+ Antiporter protein; Region: 2A0121; TIGR00900 767462005867 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 767462005868 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 767462005869 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 767462005870 BstXI restriction endonuclease; Region: RE_BstXI; pfam09552 767462005871 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462005872 non-specific DNA binding site [nucleotide binding]; other site 767462005873 salt bridge; other site 767462005874 sequence-specific DNA binding site [nucleotide binding]; other site 767462005875 DNA methylase; Region: N6_N4_Mtase; cl17433 767462005876 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 767462005877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767462005878 non-specific DNA binding site [nucleotide binding]; other site 767462005879 salt bridge; other site 767462005880 sequence-specific DNA binding site [nucleotide binding]; other site 767462005881 DNA methylase; Region: N6_N4_Mtase; pfam01555 767462005882 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970