-- dump date 20140619_123728 -- class Genbank::misc_feature -- table misc_feature_note -- id note 633699000001 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 633699000002 Replication initiation factor; Region: Rep_trans; pfam02486 633699000003 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 633699000004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699000005 Walker A motif; other site 633699000006 ATP binding site [chemical binding]; other site 633699000007 Walker B motif; other site 633699000008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 633699000009 arginine finger; other site 633699000010 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 633699000011 DnaA box-binding interface [nucleotide binding]; other site 633699000012 DNA polymerase III subunit beta; Validated; Region: PRK05643 633699000013 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 633699000014 putative DNA binding surface [nucleotide binding]; other site 633699000015 dimer interface [polypeptide binding]; other site 633699000016 beta-clamp/clamp loader binding surface; other site 633699000017 beta-clamp/translesion DNA polymerase binding surface; other site 633699000018 recombination protein F; Reviewed; Region: recF; PRK00064 633699000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 633699000020 Walker A/P-loop; other site 633699000021 ATP binding site [chemical binding]; other site 633699000022 Q-loop/lid; other site 633699000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699000024 ABC transporter signature motif; other site 633699000025 Walker B; other site 633699000026 D-loop; other site 633699000027 H-loop/switch region; other site 633699000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 633699000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633699000030 Mg2+ binding site [ion binding]; other site 633699000031 G-X-G motif; other site 633699000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 633699000033 anchoring element; other site 633699000034 dimer interface [polypeptide binding]; other site 633699000035 ATP binding site [chemical binding]; other site 633699000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 633699000037 active site 633699000038 putative metal-binding site [ion binding]; other site 633699000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 633699000040 DNA gyrase subunit A; Validated; Region: PRK05560 633699000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 633699000042 CAP-like domain; other site 633699000043 active site 633699000044 primary dimer interface [polypeptide binding]; other site 633699000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633699000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633699000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633699000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633699000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633699000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633699000051 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 633699000052 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 633699000053 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 633699000054 dimer interface [polypeptide binding]; other site 633699000055 ssDNA binding site [nucleotide binding]; other site 633699000056 tetramer (dimer of dimers) interface [polypeptide binding]; other site 633699000057 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 633699000058 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 633699000059 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 633699000060 Cl binding site [ion binding]; other site 633699000061 oligomer interface [polypeptide binding]; other site 633699000062 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 633699000063 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 633699000064 DHH family; Region: DHH; pfam01368 633699000065 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 633699000066 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 633699000067 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 633699000068 replicative DNA helicase; Region: DnaB; TIGR00665 633699000069 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 633699000070 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 633699000071 Walker A motif; other site 633699000072 ATP binding site [chemical binding]; other site 633699000073 Walker B motif; other site 633699000074 DNA binding loops [nucleotide binding] 633699000075 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 633699000076 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 633699000077 nucleotide binding site [chemical binding]; other site 633699000078 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 633699000079 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 633699000080 L-type amino acid transporter; Region: 2A0308; TIGR00911 633699000081 Transposase, Mutator family; Region: Transposase_mut; pfam00872 633699000082 MULE transposase domain; Region: MULE; pfam10551 633699000083 Bacterial surface layer protein; Region: SLAP; pfam03217 633699000084 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 633699000085 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 633699000086 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 633699000087 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 633699000088 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 633699000089 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 633699000090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699000091 NADH(P)-binding; Region: NAD_binding_10; pfam13460 633699000092 NAD(P) binding site [chemical binding]; other site 633699000093 active site 633699000094 Protein of unknown function (DUF975); Region: DUF975; pfam06161 633699000095 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 633699000096 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699000097 motif II; other site 633699000098 EDD domain protein, DegV family; Region: DegV; TIGR00762 633699000099 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 633699000100 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633699000101 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633699000102 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699000103 Walker A/P-loop; other site 633699000104 ATP binding site [chemical binding]; other site 633699000105 Q-loop/lid; other site 633699000106 ABC transporter signature motif; other site 633699000107 Walker B; other site 633699000108 D-loop; other site 633699000109 H-loop/switch region; other site 633699000110 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 633699000111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633699000112 non-specific DNA binding site [nucleotide binding]; other site 633699000113 salt bridge; other site 633699000114 sequence-specific DNA binding site [nucleotide binding]; other site 633699000115 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 633699000116 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 633699000117 G1 box; other site 633699000118 putative GEF interaction site [polypeptide binding]; other site 633699000119 GTP/Mg2+ binding site [chemical binding]; other site 633699000120 Switch I region; other site 633699000121 G2 box; other site 633699000122 G3 box; other site 633699000123 Switch II region; other site 633699000124 G4 box; other site 633699000125 G5 box; other site 633699000126 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 633699000127 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 633699000128 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 633699000129 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 633699000130 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 633699000131 Cl- selectivity filter; other site 633699000132 Cl- binding residues [ion binding]; other site 633699000133 pore gating glutamate residue; other site 633699000134 dimer interface [polypeptide binding]; other site 633699000135 H+/Cl- coupling transport residue; other site 633699000136 H+ Antiporter protein; Region: 2A0121; TIGR00900 633699000137 CsbD-like; Region: CsbD; cl17424 633699000138 Predicted membrane protein [Function unknown]; Region: COG2261 633699000139 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 633699000140 active site 633699000141 putative catalytic site [active] 633699000142 DNA binding site [nucleotide binding] 633699000143 putative phosphate binding site [ion binding]; other site 633699000144 metal binding site A [ion binding]; metal-binding site 633699000145 AP binding site [nucleotide binding]; other site 633699000146 metal binding site B [ion binding]; metal-binding site 633699000147 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 633699000148 PLD-like domain; Region: PLDc_2; pfam13091 633699000149 putative homodimer interface [polypeptide binding]; other site 633699000150 putative active site [active] 633699000151 catalytic site [active] 633699000152 DEAD-like helicases superfamily; Region: DEXDc; smart00487 633699000153 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699000154 ATP binding site [chemical binding]; other site 633699000155 putative Mg++ binding site [ion binding]; other site 633699000156 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699000157 nucleotide binding region [chemical binding]; other site 633699000158 ATP-binding site [chemical binding]; other site 633699000159 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 633699000160 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 633699000161 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 633699000162 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 633699000163 Domain of unknown function DUF20; Region: UPF0118; pfam01594 633699000164 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 633699000165 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 633699000166 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 633699000167 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 633699000168 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 633699000169 active site 633699000170 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 633699000171 active site 633699000172 catalytic triad [active] 633699000173 oxyanion hole [active] 633699000174 D-lactate dehydrogenase; Validated; Region: PRK08605 633699000175 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 633699000176 homodimer interface [polypeptide binding]; other site 633699000177 ligand binding site [chemical binding]; other site 633699000178 NAD binding site [chemical binding]; other site 633699000179 catalytic site [active] 633699000180 MucBP domain; Region: MucBP; pfam06458 633699000181 MucBP domain; Region: MucBP; pfam06458 633699000182 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 633699000183 Transcriptional regulator [Transcription]; Region: LysR; COG0583 633699000184 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 633699000185 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 633699000186 dimerization interface [polypeptide binding]; other site 633699000187 FMN-binding domain; Region: FMN_bind; pfam04205 633699000188 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 633699000189 L-aspartate oxidase; Provisional; Region: PRK06175 633699000190 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 633699000191 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 633699000192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699000193 S-adenosylmethionine binding site [chemical binding]; other site 633699000194 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 633699000195 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 633699000196 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 633699000197 active site 633699000198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699000199 putative substrate translocation pore; other site 633699000200 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 633699000201 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 633699000202 putative acyl-acceptor binding pocket; other site 633699000203 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 633699000204 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 633699000205 putative acyl-acceptor binding pocket; other site 633699000206 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633699000207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633699000208 active site 633699000209 phosphorylation site [posttranslational modification] 633699000210 intermolecular recognition site; other site 633699000211 dimerization interface [polypeptide binding]; other site 633699000212 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633699000213 DNA binding site [nucleotide binding] 633699000214 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 633699000215 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 633699000216 dimerization interface [polypeptide binding]; other site 633699000217 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633699000218 putative active site [active] 633699000219 heme pocket [chemical binding]; other site 633699000220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633699000221 dimer interface [polypeptide binding]; other site 633699000222 phosphorylation site [posttranslational modification] 633699000223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633699000224 ATP binding site [chemical binding]; other site 633699000225 Mg2+ binding site [ion binding]; other site 633699000226 G-X-G motif; other site 633699000227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 633699000228 YycH protein; Region: YycH; pfam07435 633699000229 YycH protein; Region: YycI; pfam09648 633699000230 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 633699000231 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 633699000232 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 633699000233 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 633699000234 protein binding site [polypeptide binding]; other site 633699000235 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 633699000236 Cobalt transport protein; Region: CbiQ; cl00463 633699000237 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 633699000238 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633699000239 Walker A/P-loop; other site 633699000240 ATP binding site [chemical binding]; other site 633699000241 Q-loop/lid; other site 633699000242 ABC transporter signature motif; other site 633699000243 Walker B; other site 633699000244 D-loop; other site 633699000245 H-loop/switch region; other site 633699000246 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633699000247 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 633699000248 Walker A/P-loop; other site 633699000249 ATP binding site [chemical binding]; other site 633699000250 Q-loop/lid; other site 633699000251 ABC transporter signature motif; other site 633699000252 Walker B; other site 633699000253 D-loop; other site 633699000254 H-loop/switch region; other site 633699000255 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 633699000256 Helix-turn-helix domain; Region: HTH_18; pfam12833 633699000257 heat shock protein HtpX; Provisional; Region: PRK04897 633699000258 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 633699000259 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 633699000260 transmembrane helices; other site 633699000261 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 633699000262 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 633699000263 DXD motif; other site 633699000264 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 633699000265 HD domain; Region: HD_3; cl17350 633699000266 HD domain; Region: HD_3; cl17350 633699000267 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 633699000268 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 633699000269 active site 633699000270 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 633699000271 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 633699000272 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 633699000273 Walker A/P-loop; other site 633699000274 ATP binding site [chemical binding]; other site 633699000275 Q-loop/lid; other site 633699000276 ABC transporter signature motif; other site 633699000277 Walker B; other site 633699000278 D-loop; other site 633699000279 H-loop/switch region; other site 633699000280 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633699000281 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 633699000282 substrate binding pocket [chemical binding]; other site 633699000283 membrane-bound complex binding site; other site 633699000284 hinge residues; other site 633699000285 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 633699000286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699000287 dimer interface [polypeptide binding]; other site 633699000288 conserved gate region; other site 633699000289 putative PBP binding loops; other site 633699000290 ABC-ATPase subunit interface; other site 633699000291 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 633699000292 active site 633699000293 DNA binding site [nucleotide binding] 633699000294 Uncharacterized conserved protein [Function unknown]; Region: COG3189 633699000295 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 633699000296 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 633699000297 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 633699000298 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 633699000299 DNA binding site [nucleotide binding] 633699000300 active site 633699000301 NAD-dependent deacetylase; Provisional; Region: PRK00481 633699000302 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 633699000303 NAD+ binding site [chemical binding]; other site 633699000304 substrate binding site [chemical binding]; other site 633699000305 putative Zn binding site [ion binding]; other site 633699000306 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 633699000307 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 633699000308 putative active site [active] 633699000309 catalytic site [active] 633699000310 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 633699000311 putative active site [active] 633699000312 catalytic site [active] 633699000313 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 633699000314 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 633699000315 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 633699000316 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 633699000317 RNA/DNA hybrid binding site [nucleotide binding]; other site 633699000318 active site 633699000319 Predicted secreted protein [Function unknown]; Region: COG4086 633699000320 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 633699000321 putative glycosyl transferase; Provisional; Region: PRK10073 633699000322 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 633699000323 active site 633699000324 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 633699000325 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 633699000326 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 633699000327 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 633699000328 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699000329 active site 633699000330 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 633699000331 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633699000332 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 633699000333 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 633699000334 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 633699000335 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 633699000336 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 633699000337 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 633699000338 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 633699000339 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 633699000340 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 633699000341 nucleotide binding site [chemical binding]; other site 633699000342 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 633699000343 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 633699000344 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 633699000345 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 633699000346 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 633699000347 ATP-grasp domain; Region: ATP-grasp_4; cl17255 633699000348 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 633699000349 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 633699000350 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 633699000351 YibE/F-like protein; Region: YibE_F; pfam07907 633699000352 YibE/F-like protein; Region: YibE_F; pfam07907 633699000353 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 633699000354 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 633699000355 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 633699000356 active site 633699000357 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 633699000358 catalytic site [active] 633699000359 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 633699000360 Interdomain contacts; other site 633699000361 Cytokine receptor motif; other site 633699000362 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 633699000363 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633699000364 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633699000365 DNA-binding site [nucleotide binding]; DNA binding site 633699000366 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 633699000367 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 633699000368 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 633699000369 dimer interface [polypeptide binding]; other site 633699000370 active site 633699000371 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 633699000372 putative active site [active] 633699000373 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 633699000374 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 633699000375 active site 633699000376 dimer interface [polypeptide binding]; other site 633699000377 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 633699000378 active site 633699000379 phosphorylation site [posttranslational modification] 633699000380 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 633699000381 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 633699000382 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 633699000383 active pocket/dimerization site; other site 633699000384 active site 633699000385 phosphorylation site [posttranslational modification] 633699000386 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 633699000387 Double zinc ribbon; Region: DZR; pfam12773 633699000388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 633699000389 Transposase; Region: HTH_Tnp_1; cl17663 633699000390 Helix-turn-helix domain; Region: HTH_28; pfam13518 633699000391 HTH-like domain; Region: HTH_21; pfam13276 633699000392 Integrase core domain; Region: rve; pfam00665 633699000393 Integrase core domain; Region: rve_2; pfam13333 633699000394 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 633699000395 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 633699000396 active site 633699000397 phosphorylation site [posttranslational modification] 633699000398 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633699000399 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633699000400 DNA-binding site [nucleotide binding]; DNA binding site 633699000401 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 633699000402 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 633699000403 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 633699000404 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 633699000405 Ligand Binding Site [chemical binding]; other site 633699000406 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 633699000407 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633699000408 membrane-bound complex binding site; other site 633699000409 hinge residues; other site 633699000410 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 633699000411 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 633699000412 Walker A/P-loop; other site 633699000413 ATP binding site [chemical binding]; other site 633699000414 Q-loop/lid; other site 633699000415 ABC transporter signature motif; other site 633699000416 Walker B; other site 633699000417 D-loop; other site 633699000418 H-loop/switch region; other site 633699000419 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 633699000420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699000421 dimer interface [polypeptide binding]; other site 633699000422 conserved gate region; other site 633699000423 ABC-ATPase subunit interface; other site 633699000424 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 633699000425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699000426 dimer interface [polypeptide binding]; other site 633699000427 conserved gate region; other site 633699000428 putative PBP binding loops; other site 633699000429 ABC-ATPase subunit interface; other site 633699000430 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 633699000431 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 633699000432 active site 633699000433 dimer interface [polypeptide binding]; other site 633699000434 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 633699000435 Ligand Binding Site [chemical binding]; other site 633699000436 Molecular Tunnel; other site 633699000437 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 633699000438 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 633699000439 ATP-grasp domain; Region: ATP-grasp_4; cl17255 633699000440 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 633699000441 ATP cone domain; Region: ATP-cone; pfam03477 633699000442 Class III ribonucleotide reductase; Region: RNR_III; cd01675 633699000443 effector binding site; other site 633699000444 active site 633699000445 Zn binding site [ion binding]; other site 633699000446 glycine loop; other site 633699000447 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 633699000448 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 633699000449 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 633699000450 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 633699000451 Uncharacterized conserved protein [Function unknown]; Region: COG2461 633699000452 Family of unknown function (DUF438); Region: DUF438; pfam04282 633699000453 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 633699000454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699000455 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633699000456 putative substrate translocation pore; other site 633699000457 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858 633699000458 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 633699000459 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 633699000460 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 633699000461 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 633699000462 putative active site [active] 633699000463 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 633699000464 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 633699000465 putative substrate binding site [chemical binding]; other site 633699000466 putative ATP binding site [chemical binding]; other site 633699000467 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 633699000468 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 633699000469 active site 633699000470 P-loop; other site 633699000471 phosphorylation site [posttranslational modification] 633699000472 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 633699000473 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 633699000474 active site 633699000475 phosphorylation site [posttranslational modification] 633699000476 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 633699000477 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 633699000478 active site 633699000479 Zn binding site [ion binding]; other site 633699000480 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 633699000481 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 633699000482 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 633699000483 active site 633699000484 metal-binding site [ion binding] 633699000485 nucleotide-binding site [chemical binding]; other site 633699000486 K+ potassium transporter; Region: K_trans; pfam02705 633699000487 K+ potassium transporter; Region: K_trans; pfam02705 633699000488 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 633699000489 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 633699000490 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 633699000491 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 633699000492 active site 633699000493 Bacterial SH3 domain; Region: SH3_5; pfam08460 633699000494 Bacterial SH3 domain; Region: SH3_5; pfam08460 633699000495 Bacterial SH3 domain; Region: SH3_5; pfam08460 633699000496 Bacterial SH3 domain; Region: SH3_5; pfam08460 633699000497 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 633699000498 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 633699000499 putative substrate binding site [chemical binding]; other site 633699000500 putative ATP binding site [chemical binding]; other site 633699000501 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 633699000502 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 633699000503 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 633699000504 TrkA-N domain; Region: TrkA_N; pfam02254 633699000505 TrkA-C domain; Region: TrkA_C; pfam02080 633699000506 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 633699000507 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 633699000508 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 633699000509 PAS domain; Region: PAS_10; pfam13596 633699000510 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699000511 catalytic core [active] 633699000512 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699000513 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 633699000514 GtrA-like protein; Region: GtrA; pfam04138 633699000515 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 633699000516 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 633699000517 Ligand binding site; other site 633699000518 Putative Catalytic site; other site 633699000519 DXD motif; other site 633699000520 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 633699000521 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 633699000522 Sugar transport protein; Region: Sugar_transport; pfam06800 633699000523 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 633699000524 active site 633699000525 catalytic residues [active] 633699000526 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 633699000527 membrane protein; Provisional; Region: PRK14411 633699000528 Sulfatase; Region: Sulfatase; cl17466 633699000529 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 633699000530 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 633699000531 active site 633699000532 HIGH motif; other site 633699000533 dimer interface [polypeptide binding]; other site 633699000534 KMSKS motif; other site 633699000535 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633699000536 RNA binding surface [nucleotide binding]; other site 633699000537 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 633699000538 trimer interface [polypeptide binding]; other site 633699000539 active site 633699000540 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 633699000541 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 633699000542 trimer interface [polypeptide binding]; other site 633699000543 active site 633699000544 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 633699000545 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 633699000546 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 633699000547 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 633699000548 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 633699000549 putative dimer interface [polypeptide binding]; other site 633699000550 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 633699000551 beta-galactosidase; Region: BGL; TIGR03356 633699000552 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 633699000553 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 633699000554 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633699000555 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633699000556 DNA-binding site [nucleotide binding]; DNA binding site 633699000557 UTRA domain; Region: UTRA; pfam07702 633699000558 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 633699000559 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 633699000560 beta-galactosidase; Region: BGL; TIGR03356 633699000561 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633699000562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633699000563 DNA-binding site [nucleotide binding]; DNA binding site 633699000564 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 633699000565 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 633699000566 methionine cluster; other site 633699000567 active site 633699000568 phosphorylation site [posttranslational modification] 633699000569 metal binding site [ion binding]; metal-binding site 633699000570 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 633699000571 active site 633699000572 P-loop; other site 633699000573 phosphorylation site [posttranslational modification] 633699000574 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 633699000575 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 633699000576 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 633699000577 beta-galactosidase; Region: BGL; TIGR03356 633699000578 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 633699000579 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 633699000580 nucleotide binding site [chemical binding]; other site 633699000581 CAAX protease self-immunity; Region: Abi; pfam02517 633699000582 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 633699000583 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 633699000584 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 633699000585 active site 633699000586 HIGH motif; other site 633699000587 dimer interface [polypeptide binding]; other site 633699000588 KMSKS motif; other site 633699000589 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 633699000590 catalytic motif [active] 633699000591 Zn binding site [ion binding]; other site 633699000592 Repair protein; Region: Repair_PSII; cl01535 633699000593 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 633699000594 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699000595 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 633699000596 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 633699000597 active site 633699000598 HIGH motif; other site 633699000599 KMSKS motif; other site 633699000600 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 633699000601 tRNA binding surface [nucleotide binding]; other site 633699000602 anticodon binding site; other site 633699000603 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 633699000604 dimer interface [polypeptide binding]; other site 633699000605 putative tRNA-binding site [nucleotide binding]; other site 633699000606 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 633699000607 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 633699000608 active site 633699000609 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 633699000610 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 633699000611 putative active site [active] 633699000612 putative metal binding site [ion binding]; other site 633699000613 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 633699000614 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 633699000615 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 633699000616 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 633699000617 pur operon repressor; Provisional; Region: PRK09213 633699000618 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 633699000619 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699000620 active site 633699000621 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 633699000622 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 633699000623 Substrate binding site; other site 633699000624 Mg++ binding site; other site 633699000625 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 633699000626 active site 633699000627 substrate binding site [chemical binding]; other site 633699000628 CoA binding site [chemical binding]; other site 633699000629 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 633699000630 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 633699000631 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699000632 active site 633699000633 Transcriptional regulators [Transcription]; Region: PurR; COG1609 633699000634 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 633699000635 DNA binding site [nucleotide binding] 633699000636 domain linker motif; other site 633699000637 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 633699000638 ligand binding site [chemical binding]; other site 633699000639 dimerization interface [polypeptide binding]; other site 633699000640 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 633699000641 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 633699000642 Ca binding site [ion binding]; other site 633699000643 active site 633699000644 catalytic site [active] 633699000645 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 633699000646 homodimer interface [polypeptide binding]; other site 633699000647 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 633699000648 active site 633699000649 homodimer interface [polypeptide binding]; other site 633699000650 catalytic site [active] 633699000651 maltose phosphorylase; Provisional; Region: PRK13807 633699000652 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 633699000653 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 633699000654 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 633699000655 beta-phosphoglucomutase; Region: bPGM; TIGR01990 633699000656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699000657 motif II; other site 633699000658 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 633699000659 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 633699000660 Walker A/P-loop; other site 633699000661 ATP binding site [chemical binding]; other site 633699000662 Q-loop/lid; other site 633699000663 ABC transporter signature motif; other site 633699000664 Walker B; other site 633699000665 D-loop; other site 633699000666 H-loop/switch region; other site 633699000667 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 633699000668 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 633699000669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699000670 dimer interface [polypeptide binding]; other site 633699000671 conserved gate region; other site 633699000672 putative PBP binding loops; other site 633699000673 ABC-ATPase subunit interface; other site 633699000674 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 633699000675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699000676 dimer interface [polypeptide binding]; other site 633699000677 conserved gate region; other site 633699000678 putative PBP binding loops; other site 633699000679 ABC-ATPase subunit interface; other site 633699000680 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 633699000681 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 633699000682 Ca binding site [ion binding]; other site 633699000683 active site 633699000684 catalytic site [active] 633699000685 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 633699000686 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633699000687 Zn2+ binding site [ion binding]; other site 633699000688 Mg2+ binding site [ion binding]; other site 633699000689 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 633699000690 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 633699000691 CTP synthetase; Validated; Region: pyrG; PRK05380 633699000692 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 633699000693 Catalytic site [active] 633699000694 active site 633699000695 UTP binding site [chemical binding]; other site 633699000696 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 633699000697 active site 633699000698 putative oxyanion hole; other site 633699000699 catalytic triad [active] 633699000700 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 633699000701 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 633699000702 hinge; other site 633699000703 active site 633699000704 xanthine permease; Region: pbuX; TIGR03173 633699000705 Sulfate transporter family; Region: Sulfate_transp; pfam00916 633699000706 xanthine phosphoribosyltransferase; Validated; Region: PRK09219 633699000707 GMP synthase; Reviewed; Region: guaA; PRK00074 633699000708 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 633699000709 AMP/PPi binding site [chemical binding]; other site 633699000710 candidate oxyanion hole; other site 633699000711 catalytic triad [active] 633699000712 potential glutamine specificity residues [chemical binding]; other site 633699000713 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 633699000714 ATP Binding subdomain [chemical binding]; other site 633699000715 Ligand Binding sites [chemical binding]; other site 633699000716 Dimerization subdomain; other site 633699000717 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 633699000718 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 633699000719 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 633699000720 DNA methylase; Region: N6_N4_Mtase; pfam01555 633699000721 DNA methylase; Region: N6_N4_Mtase; pfam01555 633699000722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 633699000723 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699000724 ATP binding site [chemical binding]; other site 633699000725 putative Mg++ binding site [ion binding]; other site 633699000726 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633699000727 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 633699000728 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 633699000729 substrate binding site [chemical binding]; other site 633699000730 Transposase; Region: DDE_Tnp_ISL3; pfam01610 633699000731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 633699000732 Homeodomain-like domain; Region: HTH_23; cl17451 633699000733 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 633699000734 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 633699000735 Predicted transcriptional regulators [Transcription]; Region: COG1733 633699000736 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 633699000737 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 633699000738 dimer interface [polypeptide binding]; other site 633699000739 FMN binding site [chemical binding]; other site 633699000740 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 633699000741 dimer interface [polypeptide binding]; other site 633699000742 FMN binding site [chemical binding]; other site 633699000743 NADPH bind site [chemical binding]; other site 633699000744 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 633699000745 Transposase; Region: HTH_Tnp_1; cl17663 633699000746 Helix-turn-helix domain; Region: HTH_28; pfam13518 633699000747 HTH-like domain; Region: HTH_21; pfam13276 633699000748 Integrase core domain; Region: rve; pfam00665 633699000749 Integrase core domain; Region: rve_2; pfam13333 633699000750 Peptidase family C69; Region: Peptidase_C69; pfam03577 633699000751 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 633699000752 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 633699000753 dimer interface [polypeptide binding]; other site 633699000754 active site 633699000755 glycine-pyridoxal phosphate binding site [chemical binding]; other site 633699000756 folate binding site [chemical binding]; other site 633699000757 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 633699000758 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 633699000759 zinc binding site [ion binding]; other site 633699000760 putative ligand binding site [chemical binding]; other site 633699000761 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 633699000762 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 633699000763 TM-ABC transporter signature motif; other site 633699000764 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 633699000765 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699000766 Walker A/P-loop; other site 633699000767 ATP binding site [chemical binding]; other site 633699000768 Q-loop/lid; other site 633699000769 ABC transporter signature motif; other site 633699000770 Walker B; other site 633699000771 D-loop; other site 633699000772 H-loop/switch region; other site 633699000773 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 633699000774 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 633699000775 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 633699000776 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 633699000777 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 633699000778 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 633699000779 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 633699000780 ATP binding site [chemical binding]; other site 633699000781 Mg++ binding site [ion binding]; other site 633699000782 motif III; other site 633699000783 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699000784 nucleotide binding region [chemical binding]; other site 633699000785 ATP-binding site [chemical binding]; other site 633699000786 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 633699000787 alanine racemase; Reviewed; Region: alr; PRK00053 633699000788 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 633699000789 active site 633699000790 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 633699000791 dimer interface [polypeptide binding]; other site 633699000792 substrate binding site [chemical binding]; other site 633699000793 catalytic residues [active] 633699000794 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 633699000795 FOG: CBS domain [General function prediction only]; Region: COG0517 633699000796 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 633699000797 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 633699000798 tetramer (dimer of dimers) interface [polypeptide binding]; other site 633699000799 NAD binding site [chemical binding]; other site 633699000800 dimer interface [polypeptide binding]; other site 633699000801 substrate binding site [chemical binding]; other site 633699000802 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 633699000803 putative active site [active] 633699000804 catalytic residue [active] 633699000805 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 633699000806 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 633699000807 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699000808 ATP binding site [chemical binding]; other site 633699000809 putative Mg++ binding site [ion binding]; other site 633699000810 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699000811 nucleotide binding region [chemical binding]; other site 633699000812 ATP-binding site [chemical binding]; other site 633699000813 TRCF domain; Region: TRCF; pfam03461 633699000814 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633699000815 RNA binding surface [nucleotide binding]; other site 633699000816 Septum formation initiator; Region: DivIC; pfam04977 633699000817 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 633699000818 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 633699000819 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 633699000820 RNA binding site [nucleotide binding]; other site 633699000821 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 633699000822 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 633699000823 Ligand Binding Site [chemical binding]; other site 633699000824 FtsH Extracellular; Region: FtsH_ext; pfam06480 633699000825 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 633699000826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699000827 Walker A motif; other site 633699000828 ATP binding site [chemical binding]; other site 633699000829 Walker B motif; other site 633699000830 arginine finger; other site 633699000831 Peptidase family M41; Region: Peptidase_M41; pfam01434 633699000832 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 633699000833 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 633699000834 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 633699000835 dimerization interface [polypeptide binding]; other site 633699000836 domain crossover interface; other site 633699000837 redox-dependent activation switch; other site 633699000838 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 633699000839 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 633699000840 FMN binding site [chemical binding]; other site 633699000841 active site 633699000842 catalytic residues [active] 633699000843 substrate binding site [chemical binding]; other site 633699000844 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 633699000845 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 633699000846 dimer interface [polypeptide binding]; other site 633699000847 putative anticodon binding site; other site 633699000848 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 633699000849 motif 1; other site 633699000850 active site 633699000851 motif 2; other site 633699000852 motif 3; other site 633699000853 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 633699000854 Clp amino terminal domain; Region: Clp_N; pfam02861 633699000855 Clp amino terminal domain; Region: Clp_N; pfam02861 633699000856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699000857 Walker A motif; other site 633699000858 ATP binding site [chemical binding]; other site 633699000859 Walker B motif; other site 633699000860 arginine finger; other site 633699000861 UvrB/uvrC motif; Region: UVR; pfam02151 633699000862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699000863 Walker A motif; other site 633699000864 ATP binding site [chemical binding]; other site 633699000865 Walker B motif; other site 633699000866 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 633699000867 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 633699000868 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 633699000869 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 633699000870 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 633699000871 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 633699000872 RPB1 interaction site [polypeptide binding]; other site 633699000873 RPB10 interaction site [polypeptide binding]; other site 633699000874 RPB11 interaction site [polypeptide binding]; other site 633699000875 RPB3 interaction site [polypeptide binding]; other site 633699000876 RPB12 interaction site [polypeptide binding]; other site 633699000877 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 633699000878 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 633699000879 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 633699000880 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 633699000881 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 633699000882 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 633699000883 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 633699000884 DNA binding site [nucleotide binding] 633699000885 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 633699000886 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 633699000887 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 633699000888 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 633699000889 S17 interaction site [polypeptide binding]; other site 633699000890 S8 interaction site; other site 633699000891 16S rRNA interaction site [nucleotide binding]; other site 633699000892 streptomycin interaction site [chemical binding]; other site 633699000893 23S rRNA interaction site [nucleotide binding]; other site 633699000894 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 633699000895 30S ribosomal protein S7; Validated; Region: PRK05302 633699000896 elongation factor G; Reviewed; Region: PRK12739 633699000897 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 633699000898 G1 box; other site 633699000899 putative GEF interaction site [polypeptide binding]; other site 633699000900 GTP/Mg2+ binding site [chemical binding]; other site 633699000901 Switch I region; other site 633699000902 G2 box; other site 633699000903 G3 box; other site 633699000904 Switch II region; other site 633699000905 G4 box; other site 633699000906 G5 box; other site 633699000907 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 633699000908 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 633699000909 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 633699000910 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 633699000911 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 633699000912 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 633699000913 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 633699000914 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 633699000915 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 633699000916 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 633699000917 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 633699000918 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 633699000919 putative translocon binding site; other site 633699000920 protein-rRNA interface [nucleotide binding]; other site 633699000921 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 633699000922 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 633699000923 G-X-X-G motif; other site 633699000924 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 633699000925 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 633699000926 23S rRNA interface [nucleotide binding]; other site 633699000927 5S rRNA interface [nucleotide binding]; other site 633699000928 putative antibiotic binding site [chemical binding]; other site 633699000929 L25 interface [polypeptide binding]; other site 633699000930 L27 interface [polypeptide binding]; other site 633699000931 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 633699000932 23S rRNA interface [nucleotide binding]; other site 633699000933 putative translocon interaction site; other site 633699000934 signal recognition particle (SRP54) interaction site; other site 633699000935 L23 interface [polypeptide binding]; other site 633699000936 trigger factor interaction site; other site 633699000937 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 633699000938 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 633699000939 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 633699000940 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 633699000941 RNA binding site [nucleotide binding]; other site 633699000942 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 633699000943 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 633699000944 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 633699000945 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 633699000946 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 633699000947 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 633699000948 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 633699000949 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 633699000950 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 633699000951 23S rRNA interface [nucleotide binding]; other site 633699000952 L21e interface [polypeptide binding]; other site 633699000953 5S rRNA interface [nucleotide binding]; other site 633699000954 L27 interface [polypeptide binding]; other site 633699000955 L5 interface [polypeptide binding]; other site 633699000956 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 633699000957 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 633699000958 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 633699000959 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 633699000960 23S rRNA binding site [nucleotide binding]; other site 633699000961 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 633699000962 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 633699000963 SecY translocase; Region: SecY; pfam00344 633699000964 adenylate kinase; Reviewed; Region: adk; PRK00279 633699000965 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 633699000966 AMP-binding site [chemical binding]; other site 633699000967 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 633699000968 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 633699000969 rRNA binding site [nucleotide binding]; other site 633699000970 predicted 30S ribosome binding site; other site 633699000971 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 633699000972 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 633699000973 30S ribosomal protein S13; Region: bact_S13; TIGR03631 633699000974 30S ribosomal protein S11; Validated; Region: PRK05309 633699000975 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 633699000976 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 633699000977 alphaNTD homodimer interface [polypeptide binding]; other site 633699000978 alphaNTD - beta interaction site [polypeptide binding]; other site 633699000979 alphaNTD - beta' interaction site [polypeptide binding]; other site 633699000980 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 633699000981 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 633699000982 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13640 633699000983 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633699000984 Walker A/P-loop; other site 633699000985 ATP binding site [chemical binding]; other site 633699000986 Q-loop/lid; other site 633699000987 ABC transporter signature motif; other site 633699000988 Walker B; other site 633699000989 D-loop; other site 633699000990 H-loop/switch region; other site 633699000991 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13641 633699000992 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633699000993 Walker A/P-loop; other site 633699000994 ATP binding site [chemical binding]; other site 633699000995 Q-loop/lid; other site 633699000996 ABC transporter signature motif; other site 633699000997 Walker B; other site 633699000998 D-loop; other site 633699000999 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 633699001000 H-loop/switch region; other site 633699001001 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 633699001002 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 633699001003 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 633699001004 dimerization interface 3.5A [polypeptide binding]; other site 633699001005 active site 633699001006 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 633699001007 23S rRNA interface [nucleotide binding]; other site 633699001008 L3 interface [polypeptide binding]; other site 633699001009 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 633699001010 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 633699001011 active site 633699001012 DNA binding site [nucleotide binding] 633699001013 Int/Topo IB signature motif; other site 633699001014 Plasmid replication protein; Region: Rep_2; pfam01719 633699001015 RNA helicase; Region: RNA_helicase; pfam00910 633699001016 AAA-like domain; Region: AAA_10; pfam12846 633699001017 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 633699001018 Divergent AAA domain; Region: AAA_4; pfam04326 633699001019 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 633699001020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699001021 NAD(P) binding site [chemical binding]; other site 633699001022 active site 633699001023 DJ-1 family protein; Region: not_thiJ; TIGR01383 633699001024 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 633699001025 conserved cys residue [active] 633699001026 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699001027 catalytic core [active] 633699001028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 633699001029 dimerization interface [polypeptide binding]; other site 633699001030 putative DNA binding site [nucleotide binding]; other site 633699001031 putative Zn2+ binding site [ion binding]; other site 633699001032 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 633699001033 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 633699001034 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699001035 catalytic core [active] 633699001036 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699001037 AAA domain; Region: AAA_33; pfam13671 633699001038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 633699001039 Transposase; Region: DEDD_Tnp_IS110; pfam01548 633699001040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 633699001041 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 633699001042 Transposase; Region: DEDD_Tnp_IS110; pfam01548 633699001043 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 633699001044 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 633699001045 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 633699001046 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 633699001047 trimer interface [polypeptide binding]; other site 633699001048 active site 633699001049 G bulge; other site 633699001050 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 633699001051 Transcriptional regulator [Transcription]; Region: LytR; COG1316 633699001052 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 633699001053 trimer interface [polypeptide binding]; other site 633699001054 active site 633699001055 DNA repair protein RadA; Provisional; Region: PRK11823 633699001056 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 633699001057 Walker A motif/ATP binding site; other site 633699001058 ATP binding site [chemical binding]; other site 633699001059 Walker B motif; other site 633699001060 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 633699001061 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 633699001062 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 633699001063 active site 633699001064 HIGH motif; other site 633699001065 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 633699001066 active site 633699001067 KMSKS motif; other site 633699001068 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 633699001069 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 633699001070 active site 633699001071 HIGH motif; other site 633699001072 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 633699001073 KMSKS motif; other site 633699001074 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 633699001075 tRNA binding surface [nucleotide binding]; other site 633699001076 anticodon binding site; other site 633699001077 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 633699001078 active site 633699001079 metal binding site [ion binding]; metal-binding site 633699001080 dimerization interface [polypeptide binding]; other site 633699001081 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 633699001082 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 633699001083 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 633699001084 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 633699001085 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 633699001086 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 633699001087 N- and C-terminal domain interface [polypeptide binding]; other site 633699001088 active site 633699001089 catalytic site [active] 633699001090 metal binding site [ion binding]; metal-binding site 633699001091 carbohydrate binding site [chemical binding]; other site 633699001092 ATP binding site [chemical binding]; other site 633699001093 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 633699001094 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 633699001095 TPP-binding site; other site 633699001096 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 633699001097 PYR/PP interface [polypeptide binding]; other site 633699001098 dimer interface [polypeptide binding]; other site 633699001099 TPP binding site [chemical binding]; other site 633699001100 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 633699001101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001102 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633699001103 putative substrate translocation pore; other site 633699001104 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 633699001105 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 633699001106 substrate binding pocket [chemical binding]; other site 633699001107 chain length determination region; other site 633699001108 substrate-Mg2+ binding site; other site 633699001109 catalytic residues [active] 633699001110 aspartate-rich region 1; other site 633699001111 active site lid residues [active] 633699001112 aspartate-rich region 2; other site 633699001113 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 633699001114 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 633699001115 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 633699001116 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 633699001117 putative homodimer interface [polypeptide binding]; other site 633699001118 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 633699001119 heterodimer interface [polypeptide binding]; other site 633699001120 homodimer interface [polypeptide binding]; other site 633699001121 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 633699001122 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 633699001123 23S rRNA interface [nucleotide binding]; other site 633699001124 L7/L12 interface [polypeptide binding]; other site 633699001125 putative thiostrepton binding site; other site 633699001126 L25 interface [polypeptide binding]; other site 633699001127 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 633699001128 mRNA/rRNA interface [nucleotide binding]; other site 633699001129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 633699001130 Probable transposase; Region: OrfB_IS605; pfam01385 633699001131 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 633699001132 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 633699001133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699001134 dimer interface [polypeptide binding]; other site 633699001135 conserved gate region; other site 633699001136 putative PBP binding loops; other site 633699001137 ABC-ATPase subunit interface; other site 633699001138 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633699001139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699001140 Walker A/P-loop; other site 633699001141 ATP binding site [chemical binding]; other site 633699001142 Q-loop/lid; other site 633699001143 ABC transporter signature motif; other site 633699001144 Walker B; other site 633699001145 D-loop; other site 633699001146 H-loop/switch region; other site 633699001147 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 633699001148 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633699001149 substrate binding pocket [chemical binding]; other site 633699001150 membrane-bound complex binding site; other site 633699001151 hinge residues; other site 633699001152 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 633699001153 23S rRNA interface [nucleotide binding]; other site 633699001154 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 633699001155 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 633699001156 core dimer interface [polypeptide binding]; other site 633699001157 peripheral dimer interface [polypeptide binding]; other site 633699001158 L10 interface [polypeptide binding]; other site 633699001159 L11 interface [polypeptide binding]; other site 633699001160 putative EF-Tu interaction site [polypeptide binding]; other site 633699001161 putative EF-G interaction site [polypeptide binding]; other site 633699001162 Ion transport protein; Region: Ion_trans; pfam00520 633699001163 Ion channel; Region: Ion_trans_2; pfam07885 633699001164 Methyltransferase domain; Region: Methyltransf_31; pfam13847 633699001165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699001166 S-adenosylmethionine binding site [chemical binding]; other site 633699001167 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 633699001168 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 633699001169 nucleoside/Zn binding site; other site 633699001170 dimer interface [polypeptide binding]; other site 633699001171 catalytic motif [active] 633699001172 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 633699001173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699001174 Walker A motif; other site 633699001175 ATP binding site [chemical binding]; other site 633699001176 Walker B motif; other site 633699001177 hypothetical protein; Validated; Region: PRK00153 633699001178 recombination protein RecR; Reviewed; Region: recR; PRK00076 633699001179 RecR protein; Region: RecR; pfam02132 633699001180 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 633699001181 putative active site [active] 633699001182 putative metal-binding site [ion binding]; other site 633699001183 tetramer interface [polypeptide binding]; other site 633699001184 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 633699001185 thymidylate kinase; Validated; Region: tmk; PRK00698 633699001186 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 633699001187 TMP-binding site; other site 633699001188 ATP-binding site [chemical binding]; other site 633699001189 Protein of unknown function (DUF970); Region: DUF970; cl17525 633699001190 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 633699001191 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 633699001192 Predicted methyltransferases [General function prediction only]; Region: COG0313 633699001193 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 633699001194 putative SAM binding site [chemical binding]; other site 633699001195 putative homodimer interface [polypeptide binding]; other site 633699001196 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 633699001197 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 633699001198 active site 633699001199 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 633699001200 active site 2 [active] 633699001201 active site 1 [active] 633699001202 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 633699001203 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 633699001204 Glycoprotease family; Region: Peptidase_M22; pfam00814 633699001205 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 633699001206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633699001207 Coenzyme A binding pocket [chemical binding]; other site 633699001208 UGMP family protein; Validated; Region: PRK09604 633699001209 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 633699001210 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 633699001211 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 633699001212 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 633699001213 active site 633699001214 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 633699001215 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 633699001216 GDP-binding site [chemical binding]; other site 633699001217 ACT binding site; other site 633699001218 IMP binding site; other site 633699001219 adenylosuccinate lyase; Provisional; Region: PRK07492 633699001220 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 633699001221 tetramer interface [polypeptide binding]; other site 633699001222 active site 633699001223 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 633699001224 active site 633699001225 Ap4A binding cleft/pocket [chemical binding]; other site 633699001226 P4 phosphate binding site; other site 633699001227 nudix motif; other site 633699001228 putative P2/P3 phosphate binding site [ion binding]; other site 633699001229 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 633699001230 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 633699001231 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 633699001232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699001233 Walker A/P-loop; other site 633699001234 ATP binding site [chemical binding]; other site 633699001235 Q-loop/lid; other site 633699001236 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633699001237 ABC transporter; Region: ABC_tran_2; pfam12848 633699001238 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633699001239 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 633699001240 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 633699001241 CoA binding domain; Region: CoA_binding; pfam02629 633699001242 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 633699001243 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 633699001244 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 633699001245 LytTr DNA-binding domain; Region: LytTR; smart00850 633699001246 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 633699001247 oligomerisation interface [polypeptide binding]; other site 633699001248 mobile loop; other site 633699001249 roof hairpin; other site 633699001250 chaperonin GroL; Region: GroEL; TIGR02348 633699001251 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 633699001252 ring oligomerisation interface [polypeptide binding]; other site 633699001253 ATP/Mg binding site [chemical binding]; other site 633699001254 stacking interactions; other site 633699001255 hinge regions; other site 633699001256 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633699001257 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 633699001258 Walker A/P-loop; other site 633699001259 ATP binding site [chemical binding]; other site 633699001260 Q-loop/lid; other site 633699001261 ABC transporter signature motif; other site 633699001262 Walker B; other site 633699001263 D-loop; other site 633699001264 H-loop/switch region; other site 633699001265 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 633699001266 MutS domain I; Region: MutS_I; pfam01624 633699001267 MutS domain II; Region: MutS_II; pfam05188 633699001268 MutS domain III; Region: MutS_III; pfam05192 633699001269 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 633699001270 Walker A/P-loop; other site 633699001271 ATP binding site [chemical binding]; other site 633699001272 Q-loop/lid; other site 633699001273 ABC transporter signature motif; other site 633699001274 Walker B; other site 633699001275 D-loop; other site 633699001276 H-loop/switch region; other site 633699001277 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 633699001278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633699001279 ATP binding site [chemical binding]; other site 633699001280 Mg2+ binding site [ion binding]; other site 633699001281 G-X-G motif; other site 633699001282 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 633699001283 ATP binding site [chemical binding]; other site 633699001284 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 633699001285 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 633699001286 RuvA N terminal domain; Region: RuvA_N; pfam01330 633699001287 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 633699001288 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 633699001289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699001290 Walker A motif; other site 633699001291 ATP binding site [chemical binding]; other site 633699001292 Walker B motif; other site 633699001293 arginine finger; other site 633699001294 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 633699001295 Preprotein translocase subunit; Region: YajC; cl00806 633699001296 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 633699001297 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 633699001298 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 633699001299 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 633699001300 active site 633699001301 DNA polymerase IV; Validated; Region: PRK02406 633699001302 DNA binding site [nucleotide binding] 633699001303 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 633699001304 DHH family; Region: DHH; pfam01368 633699001305 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 633699001306 DEAD-like helicases superfamily; Region: DEXDc; smart00487 633699001307 ATP binding site [chemical binding]; other site 633699001308 putative Mg++ binding site [ion binding]; other site 633699001309 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699001310 nucleotide binding region [chemical binding]; other site 633699001311 ATP-binding site [chemical binding]; other site 633699001312 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 633699001313 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 633699001314 motif 1; other site 633699001315 active site 633699001316 motif 2; other site 633699001317 motif 3; other site 633699001318 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 633699001319 DHHA1 domain; Region: DHHA1; pfam02272 633699001320 hypothetical protein; Provisional; Region: PRK05473 633699001321 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 633699001322 hypothetical protein; Provisional; Region: PRK13678 633699001323 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 633699001324 Colicin V production protein; Region: Colicin_V; pfam02674 633699001325 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 633699001326 MutS domain III; Region: MutS_III; pfam05192 633699001327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699001328 Walker A/P-loop; other site 633699001329 ATP binding site [chemical binding]; other site 633699001330 Q-loop/lid; other site 633699001331 ABC transporter signature motif; other site 633699001332 Walker B; other site 633699001333 D-loop; other site 633699001334 H-loop/switch region; other site 633699001335 Smr domain; Region: Smr; pfam01713 633699001336 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 633699001337 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 633699001338 catalytic residues [active] 633699001339 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 633699001340 glutamate racemase; Provisional; Region: PRK00865 633699001341 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 633699001342 active site 633699001343 dimerization interface [polypeptide binding]; other site 633699001344 Integrase core domain; Region: rve; pfam00665 633699001345 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 633699001346 Helix-turn-helix domain; Region: HTH_28; pfam13518 633699001347 Helix-turn-helix domain; Region: HTH_28; pfam13518 633699001348 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 633699001349 propionate/acetate kinase; Provisional; Region: PRK12379 633699001350 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 633699001351 Mechanosensitive ion channel; Region: MS_channel; pfam00924 633699001352 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 633699001353 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 633699001354 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 633699001355 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 633699001356 active site 633699001357 catabolite control protein A; Region: ccpA; TIGR01481 633699001358 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 633699001359 DNA binding site [nucleotide binding] 633699001360 domain linker motif; other site 633699001361 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 633699001362 dimerization interface [polypeptide binding]; other site 633699001363 effector binding site; other site 633699001364 Transglycosylase; Region: Transgly; pfam00912 633699001365 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 633699001366 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 633699001367 dipeptidase PepV; Reviewed; Region: PRK07318 633699001368 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 633699001369 active site 633699001370 metal binding site [ion binding]; metal-binding site 633699001371 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 633699001372 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 633699001373 active site 633699001374 catalytic site [active] 633699001375 metal binding site [ion binding]; metal-binding site 633699001376 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 633699001377 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 633699001378 active site 633699001379 metal binding site [ion binding]; metal-binding site 633699001380 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 633699001381 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 633699001382 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 633699001383 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699001384 active site 633699001385 motif I; other site 633699001386 motif II; other site 633699001387 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699001388 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 633699001389 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 633699001390 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 633699001391 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 633699001392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 633699001393 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 633699001394 general stress protein 13; Validated; Region: PRK08059 633699001395 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 633699001396 RNA binding site [nucleotide binding]; other site 633699001397 S-adenosylmethionine synthetase; Validated; Region: PRK05250 633699001398 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 633699001399 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 633699001400 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 633699001401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001402 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633699001403 putative substrate translocation pore; other site 633699001404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001405 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 633699001406 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 633699001407 active site 633699001408 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 633699001409 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 633699001410 HIGH motif; other site 633699001411 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 633699001412 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 633699001413 active site 633699001414 KMSKS motif; other site 633699001415 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 633699001416 tRNA binding surface [nucleotide binding]; other site 633699001417 stage V sporulation protein B; Region: spore_V_B; TIGR02900 633699001418 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 633699001419 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 633699001420 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 633699001421 putative substrate binding site [chemical binding]; other site 633699001422 putative ATP binding site [chemical binding]; other site 633699001423 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 633699001424 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 633699001425 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 633699001426 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 633699001427 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 633699001428 active site 633699001429 HIGH motif; other site 633699001430 KMSK motif region; other site 633699001431 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 633699001432 tRNA binding surface [nucleotide binding]; other site 633699001433 anticodon binding site; other site 633699001434 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 633699001435 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 633699001436 intersubunit interface [polypeptide binding]; other site 633699001437 active site 633699001438 zinc binding site [ion binding]; other site 633699001439 Na+ binding site [ion binding]; other site 633699001440 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 633699001441 putative Zn2+ binding site [ion binding]; other site 633699001442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699001443 Walker A motif; other site 633699001444 ATP binding site [chemical binding]; other site 633699001445 Walker B motif; other site 633699001446 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 633699001447 active site 633699001448 active pocket/dimerization site; other site 633699001449 phosphorylation site [posttranslational modification] 633699001450 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 633699001451 MgtC family; Region: MgtC; pfam02308 633699001452 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 633699001453 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 633699001454 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 633699001455 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 633699001456 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 633699001457 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699001458 active site 633699001459 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 633699001460 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 633699001461 catalytic triad [active] 633699001462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699001463 NADH(P)-binding; Region: NAD_binding_10; pfam13460 633699001464 NAD(P) binding site [chemical binding]; other site 633699001465 active site 633699001466 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 633699001467 Probable transposase; Region: OrfB_IS605; pfam01385 633699001468 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 633699001469 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 633699001470 Sec23/Sec24 zinc finger; Region: zf-Sec23_Sec24; pfam04810 633699001471 Transposase IS200 like; Region: Y1_Tnp; pfam01797 633699001472 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 633699001473 GAF domain; Region: GAF_2; pfam13185 633699001474 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 633699001475 Cl- selectivity filter; other site 633699001476 Cl- binding residues [ion binding]; other site 633699001477 pore gating glutamate residue; other site 633699001478 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 633699001479 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 633699001480 dimer interface [polypeptide binding]; other site 633699001481 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 633699001482 Membrane transport protein; Region: Mem_trans; cl09117 633699001483 Membrane transport protein; Region: Mem_trans; cl09117 633699001484 CAAX protease self-immunity; Region: Abi; pfam02517 633699001485 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 633699001486 amphipathic channel; other site 633699001487 Asn-Pro-Ala signature motifs; other site 633699001488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633699001490 putative substrate translocation pore; other site 633699001491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001492 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 633699001493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633699001495 Coenzyme A binding pocket [chemical binding]; other site 633699001496 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 633699001497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699001498 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633699001499 active site 633699001500 motif I; other site 633699001501 motif II; other site 633699001502 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699001503 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 633699001504 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 633699001505 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699001506 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633699001507 active site 633699001508 motif I; other site 633699001509 motif II; other site 633699001510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699001511 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 633699001512 Helix-turn-helix domain; Region: HTH_18; pfam12833 633699001513 uracil transporter; Provisional; Region: PRK10720 633699001514 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 633699001515 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 633699001516 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 633699001517 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 633699001518 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 633699001519 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 633699001520 active site 633699001521 phosphorylation site [posttranslational modification] 633699001522 Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414 633699001523 active site 633699001524 P-loop; other site 633699001525 phosphorylation site [posttranslational modification] 633699001526 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 633699001527 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 633699001528 transcriptional antiterminator BglG; Provisional; Region: PRK09772 633699001529 CAT RNA binding domain; Region: CAT_RBD; smart01061 633699001530 PRD domain; Region: PRD; pfam00874 633699001531 PRD domain; Region: PRD; pfam00874 633699001532 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 633699001533 methionine cluster; other site 633699001534 active site 633699001535 phosphorylation site [posttranslational modification] 633699001536 metal binding site [ion binding]; metal-binding site 633699001537 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 633699001538 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 633699001539 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 633699001540 active site 633699001541 P-loop; other site 633699001542 phosphorylation site [posttranslational modification] 633699001543 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 633699001544 beta-galactosidase; Region: BGL; TIGR03356 633699001545 Transcriptional regulator [Transcription]; Region: LysR; COG0583 633699001546 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 633699001547 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 633699001548 dimerization interface [polypeptide binding]; other site 633699001549 hypothetical protein; Validated; Region: PRK07121 633699001550 Predicted oxidoreductase [General function prediction only]; Region: COG3573 633699001551 FMN-binding domain; Region: FMN_bind; pfam04205 633699001552 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 633699001553 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 633699001554 transmembrane helices; other site 633699001555 glutaminase A; Region: Gln_ase; TIGR03814 633699001556 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 633699001557 Transcriptional regulators [Transcription]; Region: PurR; COG1609 633699001558 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 633699001559 DNA binding site [nucleotide binding] 633699001560 domain linker motif; other site 633699001561 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 633699001562 dimerization interface [polypeptide binding]; other site 633699001563 ligand binding site [chemical binding]; other site 633699001564 sodium binding site [ion binding]; other site 633699001565 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 633699001566 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 633699001567 active site turn [active] 633699001568 phosphorylation site [posttranslational modification] 633699001569 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 633699001570 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 633699001571 HPr interaction site; other site 633699001572 glycerol kinase (GK) interaction site [polypeptide binding]; other site 633699001573 active site 633699001574 phosphorylation site [posttranslational modification] 633699001575 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 633699001576 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 633699001577 Ca binding site [ion binding]; other site 633699001578 active site 633699001579 catalytic site [active] 633699001580 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 633699001581 Melibiase; Region: Melibiase; pfam02065 633699001582 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 633699001583 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 633699001584 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 633699001585 active site 633699001586 Phospholipase B; Region: Phospholip_B; pfam04916 633699001587 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 633699001588 active site 633699001589 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 633699001590 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 633699001591 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 633699001592 active site 633699001593 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 633699001594 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 633699001595 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 633699001596 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 633699001597 cationic amino acid transport permease; Region: 2A0303; TIGR00906 633699001598 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 633699001599 drug efflux system protein MdtG; Provisional; Region: PRK09874 633699001600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001601 putative substrate translocation pore; other site 633699001602 Transcriptional regulators [Transcription]; Region: MarR; COG1846 633699001603 MarR family; Region: MarR_2; pfam12802 633699001604 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 633699001605 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 633699001606 oligomer interface [polypeptide binding]; other site 633699001607 active site 633699001608 metal binding site [ion binding]; metal-binding site 633699001609 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 633699001610 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633699001611 Walker A/P-loop; other site 633699001612 ATP binding site [chemical binding]; other site 633699001613 Q-loop/lid; other site 633699001614 ABC transporter signature motif; other site 633699001615 Walker B; other site 633699001616 D-loop; other site 633699001617 H-loop/switch region; other site 633699001618 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 633699001619 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 633699001620 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 633699001621 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 633699001622 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 633699001623 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 633699001624 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 633699001625 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 633699001626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001627 putative substrate translocation pore; other site 633699001628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001629 Peptidase family C69; Region: Peptidase_C69; cl17793 633699001630 benzoate transport; Region: 2A0115; TIGR00895 633699001631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001632 putative substrate translocation pore; other site 633699001633 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 633699001634 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 633699001635 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633699001636 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699001637 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 633699001638 Walker A/P-loop; other site 633699001639 ATP binding site [chemical binding]; other site 633699001640 Q-loop/lid; other site 633699001641 ABC transporter signature motif; other site 633699001642 Walker B; other site 633699001643 D-loop; other site 633699001644 H-loop/switch region; other site 633699001645 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633699001646 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633699001647 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 633699001648 Walker A/P-loop; other site 633699001649 ATP binding site [chemical binding]; other site 633699001650 Q-loop/lid; other site 633699001651 ABC transporter signature motif; other site 633699001652 Walker B; other site 633699001653 D-loop; other site 633699001654 H-loop/switch region; other site 633699001655 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 633699001656 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633699001657 substrate binding pocket [chemical binding]; other site 633699001658 membrane-bound complex binding site; other site 633699001659 hinge residues; other site 633699001660 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 633699001661 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 633699001662 Walker A/P-loop; other site 633699001663 ATP binding site [chemical binding]; other site 633699001664 Q-loop/lid; other site 633699001665 ABC transporter signature motif; other site 633699001666 Walker B; other site 633699001667 D-loop; other site 633699001668 H-loop/switch region; other site 633699001669 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633699001670 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 633699001671 substrate binding pocket [chemical binding]; other site 633699001672 membrane-bound complex binding site; other site 633699001673 hinge residues; other site 633699001674 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 633699001675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699001676 dimer interface [polypeptide binding]; other site 633699001677 conserved gate region; other site 633699001678 putative PBP binding loops; other site 633699001679 ABC-ATPase subunit interface; other site 633699001680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699001681 dimer interface [polypeptide binding]; other site 633699001682 conserved gate region; other site 633699001683 putative PBP binding loops; other site 633699001684 ABC-ATPase subunit interface; other site 633699001685 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 633699001686 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 633699001687 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 633699001688 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 633699001689 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 633699001690 Sugar specificity; other site 633699001691 Pyrimidine base specificity; other site 633699001692 ATP-binding site [chemical binding]; other site 633699001693 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 633699001694 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 633699001695 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699001696 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 633699001697 Soluble P-type ATPase [General function prediction only]; Region: COG4087 633699001698 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 633699001699 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 633699001700 active site 633699001701 nucleophile elbow; other site 633699001702 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 633699001703 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 633699001704 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633699001705 substrate binding pocket [chemical binding]; other site 633699001706 membrane-bound complex binding site; other site 633699001707 hinge residues; other site 633699001708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699001709 dimer interface [polypeptide binding]; other site 633699001710 conserved gate region; other site 633699001711 putative PBP binding loops; other site 633699001712 ABC-ATPase subunit interface; other site 633699001713 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 633699001714 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 633699001715 Walker A/P-loop; other site 633699001716 ATP binding site [chemical binding]; other site 633699001717 Q-loop/lid; other site 633699001718 ABC transporter signature motif; other site 633699001719 Walker B; other site 633699001720 D-loop; other site 633699001721 H-loop/switch region; other site 633699001722 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 633699001723 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633699001724 Coenzyme A binding pocket [chemical binding]; other site 633699001725 PBP superfamily domain; Region: PBP_like_2; cl17296 633699001726 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 633699001727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699001728 dimer interface [polypeptide binding]; other site 633699001729 conserved gate region; other site 633699001730 putative PBP binding loops; other site 633699001731 ABC-ATPase subunit interface; other site 633699001732 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 633699001733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699001734 dimer interface [polypeptide binding]; other site 633699001735 conserved gate region; other site 633699001736 putative PBP binding loops; other site 633699001737 ABC-ATPase subunit interface; other site 633699001738 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 633699001739 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 633699001740 Walker A/P-loop; other site 633699001741 ATP binding site [chemical binding]; other site 633699001742 Q-loop/lid; other site 633699001743 ABC transporter signature motif; other site 633699001744 Walker B; other site 633699001745 D-loop; other site 633699001746 H-loop/switch region; other site 633699001747 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14251 633699001748 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 633699001749 Walker A/P-loop; other site 633699001750 ATP binding site [chemical binding]; other site 633699001751 Q-loop/lid; other site 633699001752 ABC transporter signature motif; other site 633699001753 Walker B; other site 633699001754 D-loop; other site 633699001755 H-loop/switch region; other site 633699001756 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 633699001757 PhoU domain; Region: PhoU; pfam01895 633699001758 PhoU domain; Region: PhoU; pfam01895 633699001759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 633699001760 Coenzyme A binding pocket [chemical binding]; other site 633699001761 Predicted membrane protein [Function unknown]; Region: COG1288 633699001762 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 633699001763 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 633699001764 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 633699001765 dimerization interface [polypeptide binding]; other site 633699001766 DPS ferroxidase diiron center [ion binding]; other site 633699001767 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 633699001768 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 633699001769 substrate binding site [chemical binding]; other site 633699001770 dimer interface [polypeptide binding]; other site 633699001771 ATP binding site [chemical binding]; other site 633699001772 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 633699001773 tetramer (dimer of dimers) interface [polypeptide binding]; other site 633699001774 active site 633699001775 dimer interface [polypeptide binding]; other site 633699001776 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 633699001777 active site 633699001778 tetramer interface [polypeptide binding]; other site 633699001779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633699001780 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633699001781 DNA-binding site [nucleotide binding]; DNA binding site 633699001782 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 633699001783 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 633699001784 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 633699001785 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 633699001786 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 633699001787 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 633699001788 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633699001789 putative phosphoketolase; Provisional; Region: PRK05261 633699001790 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 633699001791 TPP-binding site; other site 633699001792 XFP C-terminal domain; Region: XFP_C; pfam09363 633699001793 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 633699001794 putative FMN binding site [chemical binding]; other site 633699001795 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 633699001796 Domain of unknown function DUF21; Region: DUF21; pfam01595 633699001797 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 633699001798 Transporter associated domain; Region: CorC_HlyC; smart01091 633699001799 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699001800 active site 633699001801 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 633699001802 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 633699001803 active site 633699001804 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 633699001805 DEAD-like helicases superfamily; Region: DEXDc; smart00487 633699001806 ATP binding site [chemical binding]; other site 633699001807 putative Mg++ binding site [ion binding]; other site 633699001808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699001809 nucleotide binding region [chemical binding]; other site 633699001810 ATP-binding site [chemical binding]; other site 633699001811 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 633699001812 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 633699001813 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 633699001814 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 633699001815 active site 633699001816 homodimer interface [polypeptide binding]; other site 633699001817 Predicted membrane protein [Function unknown]; Region: COG2246 633699001818 GtrA-like protein; Region: GtrA; pfam04138 633699001819 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 633699001820 methionine aminopeptidase; Provisional; Region: PRK08671 633699001821 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 633699001822 active site 633699001823 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 633699001824 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 633699001825 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 633699001826 active site 633699001827 tetramer interface; other site 633699001828 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 633699001829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699001830 Walker A/P-loop; other site 633699001831 ATP binding site [chemical binding]; other site 633699001832 Q-loop/lid; other site 633699001833 ABC transporter signature motif; other site 633699001834 Walker B; other site 633699001835 D-loop; other site 633699001836 H-loop/switch region; other site 633699001837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699001838 dimer interface [polypeptide binding]; other site 633699001839 conserved gate region; other site 633699001840 ABC-ATPase subunit interface; other site 633699001841 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 633699001842 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 633699001843 OsmC-like protein; Region: OsmC; pfam02566 633699001844 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 633699001845 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 633699001846 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 633699001847 synthetase active site [active] 633699001848 NTP binding site [chemical binding]; other site 633699001849 metal binding site [ion binding]; metal-binding site 633699001850 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 633699001851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633699001852 active site 633699001853 phosphorylation site [posttranslational modification] 633699001854 intermolecular recognition site; other site 633699001855 dimerization interface [polypeptide binding]; other site 633699001856 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633699001857 DNA binding site [nucleotide binding] 633699001858 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 633699001859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633699001860 dimer interface [polypeptide binding]; other site 633699001861 phosphorylation site [posttranslational modification] 633699001862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633699001863 ATP binding site [chemical binding]; other site 633699001864 Mg2+ binding site [ion binding]; other site 633699001865 G-X-G motif; other site 633699001866 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 633699001867 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 633699001868 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 633699001869 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 633699001870 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 633699001871 Zn binding site [ion binding]; other site 633699001872 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633699001873 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699001874 active site 633699001875 motif I; other site 633699001876 motif II; other site 633699001877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699001878 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 633699001879 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 633699001880 glutaminase active site [active] 633699001881 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 633699001882 dimer interface [polypeptide binding]; other site 633699001883 active site 633699001884 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 633699001885 dimer interface [polypeptide binding]; other site 633699001886 active site 633699001887 Fic/DOC family; Region: Fic; cl00960 633699001888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001889 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633699001890 putative substrate translocation pore; other site 633699001891 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 633699001892 DNA binding residues [nucleotide binding] 633699001893 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 633699001894 putative dimer interface [polypeptide binding]; other site 633699001895 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 633699001896 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 633699001897 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 633699001898 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 633699001899 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 633699001900 trimer interface [polypeptide binding]; other site 633699001901 active site 633699001902 G bulge; other site 633699001903 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 633699001904 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 633699001905 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 633699001906 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 633699001907 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 633699001908 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 633699001909 pyridoxal binding site [chemical binding]; other site 633699001910 dimer interface [polypeptide binding]; other site 633699001911 ATP binding site [chemical binding]; other site 633699001912 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 633699001913 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 633699001914 active site 1 [active] 633699001915 dimer interface [polypeptide binding]; other site 633699001916 hexamer interface [polypeptide binding]; other site 633699001917 active site 2 [active] 633699001918 Phycobilisome protein; Region: Phycobilisome; cl08227 633699001919 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 633699001920 Uncharacterized conserved protein [Function unknown]; Region: COG1284 633699001921 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 633699001922 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 633699001923 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 633699001924 ArsC family; Region: ArsC; pfam03960 633699001925 putative ArsC-like catalytic residues; other site 633699001926 putative TRX-like catalytic residues [active] 633699001927 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 633699001928 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 633699001929 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 633699001930 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 633699001931 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 633699001932 active site 633699001933 elongation factor P; Validated; Region: PRK00529 633699001934 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 633699001935 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 633699001936 RNA binding site [nucleotide binding]; other site 633699001937 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 633699001938 RNA binding site [nucleotide binding]; other site 633699001939 Asp23 family; Region: Asp23; pfam03780 633699001940 transcription antitermination factor NusB; Region: nusB; TIGR01951 633699001941 putative RNA binding site [nucleotide binding]; other site 633699001942 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 633699001943 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 633699001944 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 633699001945 homodimer interface [polypeptide binding]; other site 633699001946 NADP binding site [chemical binding]; other site 633699001947 substrate binding site [chemical binding]; other site 633699001948 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 633699001949 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 633699001950 generic binding surface II; other site 633699001951 generic binding surface I; other site 633699001952 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 633699001953 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 633699001954 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 633699001955 substrate binding pocket [chemical binding]; other site 633699001956 chain length determination region; other site 633699001957 substrate-Mg2+ binding site; other site 633699001958 catalytic residues [active] 633699001959 aspartate-rich region 1; other site 633699001960 active site lid residues [active] 633699001961 aspartate-rich region 2; other site 633699001962 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 633699001963 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633699001964 RNA binding surface [nucleotide binding]; other site 633699001965 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 633699001966 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 633699001967 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 633699001968 Walker A/P-loop; other site 633699001969 ATP binding site [chemical binding]; other site 633699001970 Q-loop/lid; other site 633699001971 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 633699001972 ABC transporter signature motif; other site 633699001973 Walker B; other site 633699001974 D-loop; other site 633699001975 H-loop/switch region; other site 633699001976 HTH-like domain; Region: HTH_21; pfam13276 633699001977 Integrase core domain; Region: rve; pfam00665 633699001978 Integrase core domain; Region: rve_2; pfam13333 633699001979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 633699001980 Transposase; Region: HTH_Tnp_1; cl17663 633699001981 Helix-turn-helix domain; Region: HTH_28; pfam13518 633699001982 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 633699001983 catalytic site [active] 633699001984 G-X2-G-X-G-K; other site 633699001985 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 633699001986 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 633699001987 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 633699001988 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699001989 ATP binding site [chemical binding]; other site 633699001990 putative Mg++ binding site [ion binding]; other site 633699001991 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699001992 nucleotide binding region [chemical binding]; other site 633699001993 ATP-binding site [chemical binding]; other site 633699001994 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 633699001995 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 633699001996 putative active site [active] 633699001997 substrate binding site [chemical binding]; other site 633699001998 putative cosubstrate binding site; other site 633699001999 catalytic site [active] 633699002000 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 633699002001 substrate binding site [chemical binding]; other site 633699002002 16S rRNA methyltransferase B; Provisional; Region: PRK14902 633699002003 NusB family; Region: NusB; pfam01029 633699002004 putative RNA binding site [nucleotide binding]; other site 633699002005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699002006 S-adenosylmethionine binding site [chemical binding]; other site 633699002007 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 633699002008 Protein phosphatase 2C; Region: PP2C; pfam00481 633699002009 active site 633699002010 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 633699002011 Catalytic domain of Protein Kinases; Region: PKc; cd00180 633699002012 active site 633699002013 ATP binding site [chemical binding]; other site 633699002014 substrate binding site [chemical binding]; other site 633699002015 activation loop (A-loop); other site 633699002016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 633699002017 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 633699002018 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 633699002019 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 633699002020 GTPase RsgA; Reviewed; Region: PRK00098 633699002021 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 633699002022 RNA binding site [nucleotide binding]; other site 633699002023 homodimer interface [polypeptide binding]; other site 633699002024 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 633699002025 GTPase/Zn-binding domain interface [polypeptide binding]; other site 633699002026 GTP/Mg2+ binding site [chemical binding]; other site 633699002027 G4 box; other site 633699002028 G5 box; other site 633699002029 G1 box; other site 633699002030 Switch I region; other site 633699002031 G2 box; other site 633699002032 G3 box; other site 633699002033 Switch II region; other site 633699002034 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 633699002035 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 633699002036 substrate binding site [chemical binding]; other site 633699002037 hexamer interface [polypeptide binding]; other site 633699002038 metal binding site [ion binding]; metal-binding site 633699002039 Thiamine pyrophosphokinase; Region: TPK; cd07995 633699002040 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 633699002041 active site 633699002042 dimerization interface [polypeptide binding]; other site 633699002043 thiamine binding site [chemical binding]; other site 633699002044 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 633699002045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 633699002046 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 633699002047 DAK2 domain; Region: Dak2; pfam02734 633699002048 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 633699002049 Y-family of DNA polymerases; Region: PolY; cl12025 633699002050 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 633699002051 ssDNA binding site; other site 633699002052 generic binding surface II; other site 633699002053 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699002054 ATP binding site [chemical binding]; other site 633699002055 putative Mg++ binding site [ion binding]; other site 633699002056 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699002057 nucleotide binding region [chemical binding]; other site 633699002058 ATP-binding site [chemical binding]; other site 633699002059 putative phosphate acyltransferase; Provisional; Region: PRK05331 633699002060 acyl carrier protein; Provisional; Region: acpP; PRK00982 633699002061 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 633699002062 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 633699002063 Walker A/P-loop; other site 633699002064 ATP binding site [chemical binding]; other site 633699002065 Q-loop/lid; other site 633699002066 ABC transporter signature motif; other site 633699002067 Walker B; other site 633699002068 D-loop; other site 633699002069 H-loop/switch region; other site 633699002070 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 633699002071 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 633699002072 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 633699002073 Walker A/P-loop; other site 633699002074 ATP binding site [chemical binding]; other site 633699002075 Q-loop/lid; other site 633699002076 ABC transporter signature motif; other site 633699002077 Walker B; other site 633699002078 D-loop; other site 633699002079 H-loop/switch region; other site 633699002080 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 633699002081 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 633699002082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699002083 dimer interface [polypeptide binding]; other site 633699002084 conserved gate region; other site 633699002085 putative PBP binding loops; other site 633699002086 ABC-ATPase subunit interface; other site 633699002087 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 633699002088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699002089 dimer interface [polypeptide binding]; other site 633699002090 conserved gate region; other site 633699002091 putative PBP binding loops; other site 633699002092 ABC-ATPase subunit interface; other site 633699002093 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 633699002094 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 633699002095 peptide binding site [polypeptide binding]; other site 633699002096 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 633699002097 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 633699002098 peptide binding site [polypeptide binding]; other site 633699002099 ribonuclease III; Reviewed; Region: rnc; PRK00102 633699002100 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 633699002101 dimerization interface [polypeptide binding]; other site 633699002102 active site 633699002103 metal binding site [ion binding]; metal-binding site 633699002104 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 633699002105 dsRNA binding site [nucleotide binding]; other site 633699002106 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 633699002107 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 633699002108 Walker A/P-loop; other site 633699002109 ATP binding site [chemical binding]; other site 633699002110 Q-loop/lid; other site 633699002111 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 633699002112 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 633699002113 ABC transporter signature motif; other site 633699002114 Walker B; other site 633699002115 D-loop; other site 633699002116 H-loop/switch region; other site 633699002117 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 633699002118 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 633699002119 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 633699002120 P loop; other site 633699002121 GTP binding site [chemical binding]; other site 633699002122 Peptidase family C69; Region: Peptidase_C69; pfam03577 633699002123 putative DNA-binding protein; Validated; Region: PRK00118 633699002124 signal recognition particle protein; Provisional; Region: PRK10867 633699002125 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 633699002126 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 633699002127 P loop; other site 633699002128 GTP binding site [chemical binding]; other site 633699002129 Signal peptide binding domain; Region: SRP_SPB; pfam02978 633699002130 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 633699002131 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 633699002132 RimM N-terminal domain; Region: RimM; pfam01782 633699002133 PRC-barrel domain; Region: PRC; pfam05239 633699002134 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 633699002135 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 633699002136 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 633699002137 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 633699002138 Catalytic site [active] 633699002139 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 633699002140 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 633699002141 active site 633699002142 Ap4A binding cleft/pocket [chemical binding]; other site 633699002143 P4 phosphate binding site; other site 633699002144 nudix motif; other site 633699002145 putative P2/P3 phosphate binding site [ion binding]; other site 633699002146 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 633699002147 active site 633699002148 Fe-S cluster binding site [ion binding]; other site 633699002149 LexA repressor; Validated; Region: PRK00215 633699002150 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 633699002151 putative DNA binding site [nucleotide binding]; other site 633699002152 putative Zn2+ binding site [ion binding]; other site 633699002153 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 633699002154 Catalytic site [active] 633699002155 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 633699002156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 633699002157 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633699002158 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 633699002159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699002160 Walker A/P-loop; other site 633699002161 ATP binding site [chemical binding]; other site 633699002162 Q-loop/lid; other site 633699002163 ABC transporter signature motif; other site 633699002164 Walker B; other site 633699002165 D-loop; other site 633699002166 H-loop/switch region; other site 633699002167 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633699002168 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633699002169 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 633699002170 Walker A/P-loop; other site 633699002171 ATP binding site [chemical binding]; other site 633699002172 Q-loop/lid; other site 633699002173 ABC transporter signature motif; other site 633699002174 Walker B; other site 633699002175 D-loop; other site 633699002176 H-loop/switch region; other site 633699002177 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 633699002178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699002179 S-adenosylmethionine binding site [chemical binding]; other site 633699002180 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 633699002181 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 633699002182 putative acyl-acceptor binding pocket; other site 633699002183 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 633699002184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699002185 S-adenosylmethionine binding site [chemical binding]; other site 633699002186 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 633699002187 GIY-YIG motif/motif A; other site 633699002188 putative active site [active] 633699002189 putative metal binding site [ion binding]; other site 633699002190 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 633699002191 rRNA interaction site [nucleotide binding]; other site 633699002192 S8 interaction site; other site 633699002193 putative laminin-1 binding site; other site 633699002194 elongation factor Ts; Provisional; Region: tsf; PRK09377 633699002195 UBA/TS-N domain; Region: UBA; pfam00627 633699002196 Elongation factor TS; Region: EF_TS; pfam00889 633699002197 Elongation factor TS; Region: EF_TS; pfam00889 633699002198 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 633699002199 putative nucleotide binding site [chemical binding]; other site 633699002200 uridine monophosphate binding site [chemical binding]; other site 633699002201 homohexameric interface [polypeptide binding]; other site 633699002202 ribosome recycling factor; Reviewed; Region: frr; PRK00083 633699002203 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 633699002204 hinge region; other site 633699002205 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 633699002206 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 633699002207 catalytic residue [active] 633699002208 putative FPP diphosphate binding site; other site 633699002209 putative FPP binding hydrophobic cleft; other site 633699002210 dimer interface [polypeptide binding]; other site 633699002211 putative IPP diphosphate binding site; other site 633699002212 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 633699002213 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 633699002214 RIP metalloprotease RseP; Region: TIGR00054 633699002215 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 633699002216 active site 633699002217 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 633699002218 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 633699002219 protein binding site [polypeptide binding]; other site 633699002220 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 633699002221 putative substrate binding region [chemical binding]; other site 633699002222 prolyl-tRNA synthetase; Provisional; Region: PRK09194 633699002223 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 633699002224 dimer interface [polypeptide binding]; other site 633699002225 motif 1; other site 633699002226 active site 633699002227 motif 2; other site 633699002228 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 633699002229 putative deacylase active site [active] 633699002230 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 633699002231 active site 633699002232 motif 3; other site 633699002233 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 633699002234 anticodon binding site; other site 633699002235 DNA polymerase III PolC; Validated; Region: polC; PRK00448 633699002236 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 633699002237 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 633699002238 generic binding surface II; other site 633699002239 generic binding surface I; other site 633699002240 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 633699002241 active site 633699002242 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 633699002243 active site 633699002244 catalytic site [active] 633699002245 substrate binding site [chemical binding]; other site 633699002246 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 633699002247 ribosome maturation protein RimP; Reviewed; Region: PRK00092 633699002248 Sm and related proteins; Region: Sm_like; cl00259 633699002249 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 633699002250 putative oligomer interface [polypeptide binding]; other site 633699002251 putative RNA binding site [nucleotide binding]; other site 633699002252 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 633699002253 NusA N-terminal domain; Region: NusA_N; pfam08529 633699002254 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 633699002255 RNA binding site [nucleotide binding]; other site 633699002256 homodimer interface [polypeptide binding]; other site 633699002257 NusA-like KH domain; Region: KH_5; pfam13184 633699002258 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 633699002259 G-X-X-G motif; other site 633699002260 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 633699002261 putative RNA binding cleft [nucleotide binding]; other site 633699002262 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 633699002263 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 633699002264 translation initiation factor IF-2; Validated; Region: infB; PRK05306 633699002265 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 633699002266 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 633699002267 G1 box; other site 633699002268 putative GEF interaction site [polypeptide binding]; other site 633699002269 GTP/Mg2+ binding site [chemical binding]; other site 633699002270 Switch I region; other site 633699002271 G2 box; other site 633699002272 G3 box; other site 633699002273 Switch II region; other site 633699002274 G4 box; other site 633699002275 G5 box; other site 633699002276 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 633699002277 Translation-initiation factor 2; Region: IF-2; pfam11987 633699002278 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 633699002279 ribosome-binding factor A; Provisional; Region: PRK13818 633699002280 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 633699002281 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 633699002282 RNA binding site [nucleotide binding]; other site 633699002283 active site 633699002284 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 633699002285 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 633699002286 active site 633699002287 Riboflavin kinase; Region: Flavokinase; smart00904 633699002288 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 633699002289 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633699002290 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633699002291 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 633699002292 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 633699002293 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 633699002294 GrpE; Region: GrpE; pfam01025 633699002295 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 633699002296 dimer interface [polypeptide binding]; other site 633699002297 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 633699002298 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 633699002299 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 633699002300 nucleotide binding site [chemical binding]; other site 633699002301 NEF interaction site [polypeptide binding]; other site 633699002302 SBD interface [polypeptide binding]; other site 633699002303 chaperone protein DnaJ; Provisional; Region: PRK14276 633699002304 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 633699002305 HSP70 interaction site [polypeptide binding]; other site 633699002306 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 633699002307 substrate binding site [polypeptide binding]; other site 633699002308 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 633699002309 Zn binding sites [ion binding]; other site 633699002310 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 633699002311 dimer interface [polypeptide binding]; other site 633699002312 GTP-binding protein LepA; Provisional; Region: PRK05433 633699002313 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 633699002314 G1 box; other site 633699002315 putative GEF interaction site [polypeptide binding]; other site 633699002316 GTP/Mg2+ binding site [chemical binding]; other site 633699002317 Switch I region; other site 633699002318 G2 box; other site 633699002319 G3 box; other site 633699002320 Switch II region; other site 633699002321 G4 box; other site 633699002322 G5 box; other site 633699002323 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 633699002324 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 633699002325 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 633699002326 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 633699002327 active site 633699002328 catalytic site [active] 633699002329 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 633699002330 DHH family; Region: DHH; pfam01368 633699002331 DHHA1 domain; Region: DHHA1; pfam02272 633699002332 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 633699002333 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699002334 active site 633699002335 inner membrane transporter YjeM; Provisional; Region: PRK15238 633699002336 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 633699002337 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 633699002338 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 633699002339 putative active site [active] 633699002340 catalytic site [active] 633699002341 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 633699002342 putative active site [active] 633699002343 catalytic site [active] 633699002344 thymidylate synthase; Region: thym_sym; TIGR03284 633699002345 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 633699002346 dimerization interface [polypeptide binding]; other site 633699002347 active site 633699002348 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 633699002349 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 633699002350 folate binding site [chemical binding]; other site 633699002351 NADP+ binding site [chemical binding]; other site 633699002352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699002353 MFS/sugar transport protein; Region: MFS_2; pfam13347 633699002354 putative substrate translocation pore; other site 633699002355 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 633699002356 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 633699002357 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699002358 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699002359 motif II; other site 633699002360 Transcriptional regulator [Transcription]; Region: LysR; COG0583 633699002361 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 633699002362 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 633699002363 dimerization interface [polypeptide binding]; other site 633699002364 integrase; Provisional; Region: int; PHA02601 633699002365 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 633699002366 Int/Topo IB signature motif; other site 633699002367 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 633699002368 Peptidase family M48; Region: Peptidase_M48; cl12018 633699002369 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633699002370 non-specific DNA binding site [nucleotide binding]; other site 633699002371 salt bridge; other site 633699002372 sequence-specific DNA binding site [nucleotide binding]; other site 633699002373 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633699002374 non-specific DNA binding site [nucleotide binding]; other site 633699002375 salt bridge; other site 633699002376 sequence-specific DNA binding site [nucleotide binding]; other site 633699002377 Helix-turn-helix domain; Region: HTH_17; pfam12728 633699002378 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 633699002379 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 633699002380 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 633699002381 putative Mg++ binding site [ion binding]; other site 633699002382 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699002383 nucleotide binding region [chemical binding]; other site 633699002384 ATP-binding site [chemical binding]; other site 633699002385 AAA domain; Region: AAA_24; pfam13479 633699002386 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 633699002387 polymerase nucleotide-binding site; other site 633699002388 DNA-binding residues [nucleotide binding]; DNA binding site 633699002389 nucleotide binding site [chemical binding]; other site 633699002390 primase nucleotide-binding site [nucleotide binding]; other site 633699002391 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 633699002392 Virulence-associated protein E; Region: VirE; pfam05272 633699002393 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 633699002394 VRR-NUC domain; Region: VRR_NUC; pfam08774 633699002395 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 633699002396 Terminase small subunit; Region: Terminase_2; pfam03592 633699002397 Phage terminase large subunit; Region: Terminase_3; pfam04466 633699002398 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 633699002399 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 633699002400 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 633699002401 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 633699002402 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 633699002403 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 633699002404 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 633699002405 Phage major tail protein 2; Region: Phage_tail_2; cl11463 633699002406 Phage protein; Region: DUF3647; pfam12363 633699002407 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 633699002408 membrane protein P6; Region: PHA01399 633699002409 membrane protein P6; Region: PHA01399 633699002410 membrane protein P6; Region: PHA01399 633699002411 Phage tail protein; Region: Sipho_tail; cl17486 633699002412 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 633699002413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 633699002414 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 633699002415 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 633699002416 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 633699002417 active site 633699002418 Bacterial SH3 domain; Region: SH3_5; pfam08460 633699002419 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 633699002420 active site 633699002421 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 633699002422 enolase; Provisional; Region: eno; PRK00077 633699002423 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 633699002424 dimer interface [polypeptide binding]; other site 633699002425 metal binding site [ion binding]; metal-binding site 633699002426 substrate binding pocket [chemical binding]; other site 633699002427 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 633699002428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699002429 Walker A/P-loop; other site 633699002430 ATP binding site [chemical binding]; other site 633699002431 Q-loop/lid; other site 633699002432 ABC transporter signature motif; other site 633699002433 Walker B; other site 633699002434 D-loop; other site 633699002435 H-loop/switch region; other site 633699002436 ABC transporter; Region: ABC_tran_2; pfam12848 633699002437 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633699002438 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 633699002439 active site 633699002440 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 633699002441 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633699002442 non-specific DNA binding site [nucleotide binding]; other site 633699002443 salt bridge; other site 633699002444 sequence-specific DNA binding site [nucleotide binding]; other site 633699002445 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 633699002446 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 633699002447 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 633699002448 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 633699002449 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 633699002450 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 633699002451 Walker A/P-loop; other site 633699002452 ATP binding site [chemical binding]; other site 633699002453 Q-loop/lid; other site 633699002454 ABC transporter signature motif; other site 633699002455 Walker B; other site 633699002456 D-loop; other site 633699002457 H-loop/switch region; other site 633699002458 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 633699002459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699002460 dimer interface [polypeptide binding]; other site 633699002461 conserved gate region; other site 633699002462 ABC-ATPase subunit interface; other site 633699002463 fumarate hydratase; Reviewed; Region: fumC; PRK00485 633699002464 Class II fumarases; Region: Fumarase_classII; cd01362 633699002465 active site 633699002466 tetramer interface [polypeptide binding]; other site 633699002467 L-aspartate oxidase; Provisional; Region: PRK06175 633699002468 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 633699002469 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 633699002470 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 633699002471 tetramer (dimer of dimers) interface [polypeptide binding]; other site 633699002472 NAD binding site [chemical binding]; other site 633699002473 dimer interface [polypeptide binding]; other site 633699002474 substrate binding site [chemical binding]; other site 633699002475 Uncharacterized conserved protein [Function unknown]; Region: COG2966 633699002476 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 633699002477 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 633699002478 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 633699002479 active site 633699002480 homodimer interface [polypeptide binding]; other site 633699002481 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 633699002482 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699002483 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699002484 motif II; other site 633699002485 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 633699002486 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 633699002487 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 633699002488 putative deacylase active site [active] 633699002489 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 633699002490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699002491 S-adenosylmethionine binding site [chemical binding]; other site 633699002492 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 633699002493 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633699002494 Zn2+ binding site [ion binding]; other site 633699002495 Mg2+ binding site [ion binding]; other site 633699002496 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 633699002497 synthetase active site [active] 633699002498 NTP binding site [chemical binding]; other site 633699002499 metal binding site [ion binding]; metal-binding site 633699002500 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 633699002501 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 633699002502 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 633699002503 putative active site [active] 633699002504 dimerization interface [polypeptide binding]; other site 633699002505 putative tRNAtyr binding site [nucleotide binding]; other site 633699002506 histidyl-tRNA synthetase; Region: hisS; TIGR00442 633699002507 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 633699002508 dimer interface [polypeptide binding]; other site 633699002509 motif 1; other site 633699002510 active site 633699002511 motif 2; other site 633699002512 motif 3; other site 633699002513 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 633699002514 anticodon binding site; other site 633699002515 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 633699002516 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 633699002517 dimer interface [polypeptide binding]; other site 633699002518 anticodon binding site; other site 633699002519 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 633699002520 homodimer interface [polypeptide binding]; other site 633699002521 motif 1; other site 633699002522 active site 633699002523 motif 2; other site 633699002524 GAD domain; Region: GAD; pfam02938 633699002525 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 633699002526 active site 633699002527 motif 3; other site 633699002528 aromatic amino acid aminotransferase; Validated; Region: PRK07309 633699002529 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 633699002530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633699002531 homodimer interface [polypeptide binding]; other site 633699002532 catalytic residue [active] 633699002533 methionine sulfoxide reductase B; Provisional; Region: PRK00222 633699002534 SelR domain; Region: SelR; pfam01641 633699002535 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 633699002536 active site 633699002537 catalytic triad [active] 633699002538 oxyanion hole [active] 633699002539 methionine sulfoxide reductase A; Provisional; Region: PRK14054 633699002540 Uncharacterized conserved protein [Function unknown]; Region: COG1284 633699002541 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 633699002542 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 633699002543 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 633699002544 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 633699002545 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 633699002546 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 633699002547 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 633699002548 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 633699002549 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 633699002550 Yqey-like protein; Region: YqeY; pfam09424 633699002551 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 633699002552 PhoH-like protein; Region: PhoH; pfam02562 633699002553 probable rRNA maturation factor YbeY; Region: TIGR00043 633699002554 GTPase Era; Reviewed; Region: era; PRK00089 633699002555 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 633699002556 G1 box; other site 633699002557 GTP/Mg2+ binding site [chemical binding]; other site 633699002558 Switch I region; other site 633699002559 G2 box; other site 633699002560 Switch II region; other site 633699002561 G3 box; other site 633699002562 G4 box; other site 633699002563 G5 box; other site 633699002564 Recombination protein O N terminal; Region: RecO_N; pfam11967 633699002565 DNA repair protein RecO; Region: reco; TIGR00613 633699002566 Recombination protein O C terminal; Region: RecO_C; pfam02565 633699002567 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 633699002568 motif 1; other site 633699002569 dimer interface [polypeptide binding]; other site 633699002570 active site 633699002571 motif 2; other site 633699002572 motif 3; other site 633699002573 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 633699002574 DALR anticodon binding domain; Region: DALR_1; pfam05746 633699002575 DNA primase; Validated; Region: dnaG; PRK05667 633699002576 CHC2 zinc finger; Region: zf-CHC2; cl17510 633699002577 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 633699002578 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 633699002579 active site 633699002580 metal binding site [ion binding]; metal-binding site 633699002581 interdomain interaction site; other site 633699002582 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 633699002583 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 633699002584 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 633699002585 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 633699002586 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 633699002587 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 633699002588 DNA binding residues [nucleotide binding] 633699002589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699002590 dimer interface [polypeptide binding]; other site 633699002591 conserved gate region; other site 633699002592 putative PBP binding loops; other site 633699002593 ABC-ATPase subunit interface; other site 633699002594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699002595 dimer interface [polypeptide binding]; other site 633699002596 conserved gate region; other site 633699002597 putative PBP binding loops; other site 633699002598 ABC-ATPase subunit interface; other site 633699002599 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 633699002600 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 633699002601 Walker A/P-loop; other site 633699002602 ATP binding site [chemical binding]; other site 633699002603 Q-loop/lid; other site 633699002604 ABC transporter signature motif; other site 633699002605 Walker B; other site 633699002606 D-loop; other site 633699002607 H-loop/switch region; other site 633699002608 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 633699002609 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633699002610 substrate binding pocket [chemical binding]; other site 633699002611 membrane-bound complex binding site; other site 633699002612 hinge residues; other site 633699002613 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 633699002614 Family of unknown function (DUF633); Region: DUF633; pfam04816 633699002615 Uncharacterized conserved protein [Function unknown]; Region: COG0327 633699002616 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 633699002617 peptidase T; Region: peptidase-T; TIGR01882 633699002618 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 633699002619 metal binding site [ion binding]; metal-binding site 633699002620 dimer interface [polypeptide binding]; other site 633699002621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633699002622 DNA-binding site [nucleotide binding]; DNA binding site 633699002623 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 633699002624 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 633699002625 Walker A/P-loop; other site 633699002626 ATP binding site [chemical binding]; other site 633699002627 ABC transporter signature motif; other site 633699002628 Walker B; other site 633699002629 D-loop; other site 633699002630 H-loop/switch region; other site 633699002631 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 633699002632 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 633699002633 Catalytic site [active] 633699002634 Chitin synthase III catalytic subunit; Region: Chs3p; pfam12271 633699002635 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 633699002636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699002637 S-adenosylmethionine binding site [chemical binding]; other site 633699002638 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 633699002639 hypothetical protein; Provisional; Region: PRK00967 633699002640 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 633699002641 sugar phosphate phosphatase; Provisional; Region: PRK10513 633699002642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699002643 active site 633699002644 motif I; other site 633699002645 motif II; other site 633699002646 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 633699002647 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 633699002648 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699002649 active site 633699002650 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 633699002651 active site 633699002652 dimer interface [polypeptide binding]; other site 633699002653 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 633699002654 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 633699002655 heterodimer interface [polypeptide binding]; other site 633699002656 active site 633699002657 FMN binding site [chemical binding]; other site 633699002658 homodimer interface [polypeptide binding]; other site 633699002659 substrate binding site [chemical binding]; other site 633699002660 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 633699002661 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699002662 active site 633699002663 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 633699002664 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 633699002665 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 633699002666 dihydroorotase; Validated; Region: pyrC; PRK09357 633699002667 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 633699002668 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 633699002669 active site 633699002670 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 633699002671 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 633699002672 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 633699002673 catalytic site [active] 633699002674 subunit interface [polypeptide binding]; other site 633699002675 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 633699002676 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 633699002677 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 633699002678 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 633699002679 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 633699002680 ATP-grasp domain; Region: ATP-grasp_4; cl17255 633699002681 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 633699002682 IMP binding site; other site 633699002683 dimer interface [polypeptide binding]; other site 633699002684 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 633699002685 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699002686 active site 633699002687 Isochorismatase family; Region: Isochorismatase; pfam00857 633699002688 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 633699002689 catalytic triad [active] 633699002690 conserved cis-peptide bond; other site 633699002691 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 633699002692 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 633699002693 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 633699002694 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 633699002695 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 633699002696 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 633699002697 active site 633699002698 Zn binding site [ion binding]; other site 633699002699 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 633699002700 FMN binding site [chemical binding]; other site 633699002701 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 633699002702 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 633699002703 dimer interface [polypeptide binding]; other site 633699002704 glycerate kinase; Region: TIGR00045 633699002705 HTH-like domain; Region: HTH_21; pfam13276 633699002706 Integrase core domain; Region: rve; pfam00665 633699002707 Integrase core domain; Region: rve_2; pfam13333 633699002708 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 633699002709 Transposase; Region: HTH_Tnp_1; cl17663 633699002710 Helix-turn-helix domain; Region: HTH_28; pfam13518 633699002711 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 633699002712 HflK protein; Region: hflK; TIGR01933 633699002713 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633699002714 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633699002715 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 633699002716 Walker A/P-loop; other site 633699002717 ATP binding site [chemical binding]; other site 633699002718 Q-loop/lid; other site 633699002719 ABC transporter signature motif; other site 633699002720 Walker B; other site 633699002721 D-loop; other site 633699002722 H-loop/switch region; other site 633699002723 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633699002724 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633699002725 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 633699002726 Walker A/P-loop; other site 633699002727 ATP binding site [chemical binding]; other site 633699002728 Q-loop/lid; other site 633699002729 ABC transporter signature motif; other site 633699002730 Walker B; other site 633699002731 D-loop; other site 633699002732 H-loop/switch region; other site 633699002733 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 633699002734 FMN binding site [chemical binding]; other site 633699002735 dimer interface [polypeptide binding]; other site 633699002736 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633699002737 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633699002738 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 633699002739 Walker A/P-loop; other site 633699002740 ATP binding site [chemical binding]; other site 633699002741 Q-loop/lid; other site 633699002742 ABC transporter signature motif; other site 633699002743 Walker B; other site 633699002744 D-loop; other site 633699002745 H-loop/switch region; other site 633699002746 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 633699002747 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 633699002748 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 633699002749 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633699002750 Coenzyme A binding pocket [chemical binding]; other site 633699002751 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 633699002752 nucleotide binding site/active site [active] 633699002753 HIT family signature motif; other site 633699002754 catalytic residue [active] 633699002755 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 633699002756 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535 633699002757 metal binding site [ion binding]; metal-binding site 633699002758 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 633699002759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 633699002760 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 633699002761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633699002762 Coenzyme A binding pocket [chemical binding]; other site 633699002763 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 633699002764 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 633699002765 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 633699002766 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 633699002767 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699002768 catalytic core [active] 633699002769 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 633699002770 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 633699002771 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 633699002772 homodimer interface [polypeptide binding]; other site 633699002773 NADP binding site [chemical binding]; other site 633699002774 substrate binding site [chemical binding]; other site 633699002775 D-ribose pyranase; Provisional; Region: PRK11797 633699002776 Sugar transport protein; Region: Sugar_transport; pfam06800 633699002777 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 633699002778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699002779 H+ Antiporter protein; Region: 2A0121; TIGR00900 633699002780 putative substrate translocation pore; other site 633699002781 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 633699002782 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633699002783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699002784 Walker A/P-loop; other site 633699002785 ATP binding site [chemical binding]; other site 633699002786 Q-loop/lid; other site 633699002787 ABC transporter signature motif; other site 633699002788 Walker B; other site 633699002789 D-loop; other site 633699002790 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 633699002791 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633699002792 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 633699002793 Walker A/P-loop; other site 633699002794 ATP binding site [chemical binding]; other site 633699002795 Q-loop/lid; other site 633699002796 ABC transporter signature motif; other site 633699002797 Walker B; other site 633699002798 D-loop; other site 633699002799 H-loop/switch region; other site 633699002800 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 633699002801 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 633699002802 homotetramer interface [polypeptide binding]; other site 633699002803 FMN binding site [chemical binding]; other site 633699002804 homodimer contacts [polypeptide binding]; other site 633699002805 putative active site [active] 633699002806 putative substrate binding site [chemical binding]; other site 633699002807 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 633699002808 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 633699002809 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 633699002810 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 633699002811 diphosphomevalonate decarboxylase; Region: PLN02407 633699002812 mevalonate kinase; Region: mevalon_kin; TIGR00549 633699002813 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 633699002814 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 633699002815 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 633699002816 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 633699002817 Part of AAA domain; Region: AAA_19; pfam13245 633699002818 Family description; Region: UvrD_C_2; pfam13538 633699002819 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 633699002820 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 633699002821 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 633699002822 active site 633699002823 catalytic site [active] 633699002824 substrate binding site [chemical binding]; other site 633699002825 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699002826 ATP binding site [chemical binding]; other site 633699002827 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 633699002828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 633699002829 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 633699002830 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 633699002831 putative dimer interface [polypeptide binding]; other site 633699002832 putative anticodon binding site; other site 633699002833 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 633699002834 homodimer interface [polypeptide binding]; other site 633699002835 motif 1; other site 633699002836 motif 2; other site 633699002837 active site 633699002838 motif 3; other site 633699002839 Helix-turn-helix domain; Region: HTH_36; pfam13730 633699002840 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 633699002841 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 633699002842 endonuclease III; Region: ENDO3c; smart00478 633699002843 minor groove reading motif; other site 633699002844 helix-hairpin-helix signature motif; other site 633699002845 substrate binding pocket [chemical binding]; other site 633699002846 active site 633699002847 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 633699002848 Transposase; Region: HTH_Tnp_1; cl17663 633699002849 Helix-turn-helix domain; Region: HTH_28; pfam13518 633699002850 HTH-like domain; Region: HTH_21; pfam13276 633699002851 Integrase core domain; Region: rve; pfam00665 633699002852 Integrase core domain; Region: rve_2; pfam13333 633699002853 Transglycosylase; Region: Transgly; pfam00912 633699002854 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 633699002855 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 633699002856 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 633699002857 hypothetical protein; Provisional; Region: PRK13660 633699002858 DivIVA protein; Region: DivIVA; pfam05103 633699002859 DivIVA domain; Region: DivI1A_domain; TIGR03544 633699002860 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 633699002861 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 633699002862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 633699002863 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 633699002864 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 633699002865 active site 633699002866 metal binding site [ion binding]; metal-binding site 633699002867 Acyltransferase family; Region: Acyl_transf_3; pfam01757 633699002868 EDD domain protein, DegV family; Region: DegV; TIGR00762 633699002869 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 633699002870 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 633699002871 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 633699002872 Potassium binding sites [ion binding]; other site 633699002873 Cesium cation binding sites [ion binding]; other site 633699002874 lipoprotein signal peptidase; Provisional; Region: PRK14797 633699002875 lipoprotein signal peptidase; Provisional; Region: PRK14787 633699002876 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 633699002877 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633699002878 RNA binding surface [nucleotide binding]; other site 633699002879 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 633699002880 active site 633699002881 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 633699002882 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 633699002883 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 633699002884 conserved cys residue [active] 633699002885 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 633699002886 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 633699002887 ATP-grasp domain; Region: ATP-grasp_4; cl17255 633699002888 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 633699002889 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 633699002890 ATP-grasp domain; Region: ATP-grasp_4; cl17255 633699002891 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 633699002892 IMP binding site; other site 633699002893 dimer interface [polypeptide binding]; other site 633699002894 interdomain contacts; other site 633699002895 partial ornithine binding site; other site 633699002896 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 633699002897 Domain of unknown function (DUF814); Region: DUF814; pfam05670 633699002898 MarR family; Region: MarR_2; pfam12802 633699002899 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 633699002900 EDD domain protein, DegV family; Region: DegV; TIGR00762 633699002901 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 633699002902 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 633699002903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 633699002904 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 633699002905 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 633699002906 active site 633699002907 DNA binding site [nucleotide binding] 633699002908 Int/Topo IB signature motif; other site 633699002909 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 633699002910 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 633699002911 active site 633699002912 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 633699002913 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699002914 ATP binding site [chemical binding]; other site 633699002915 putative Mg++ binding site [ion binding]; other site 633699002916 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699002917 nucleotide binding region [chemical binding]; other site 633699002918 ATP-binding site [chemical binding]; other site 633699002919 RQC domain; Region: RQC; pfam09382 633699002920 HRDC domain; Region: HRDC; pfam00570 633699002921 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 633699002922 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 633699002923 DHHA2 domain; Region: DHHA2; pfam02833 633699002924 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 633699002925 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 633699002926 CAP-like domain; other site 633699002927 active site 633699002928 primary dimer interface [polypeptide binding]; other site 633699002929 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633699002930 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633699002931 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 633699002932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633699002933 Mg2+ binding site [ion binding]; other site 633699002934 G-X-G motif; other site 633699002935 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 633699002936 anchoring element; other site 633699002937 dimer interface [polypeptide binding]; other site 633699002938 ATP binding site [chemical binding]; other site 633699002939 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 633699002940 active site 633699002941 putative metal-binding site [ion binding]; other site 633699002942 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 633699002943 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 633699002944 maltose O-acetyltransferase; Provisional; Region: PRK10092 633699002945 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 633699002946 active site 633699002947 substrate binding site [chemical binding]; other site 633699002948 trimer interface [polypeptide binding]; other site 633699002949 CoA binding site [chemical binding]; other site 633699002950 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 633699002951 active site 633699002952 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 633699002953 catalytic tetrad [active] 633699002954 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 633699002955 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 633699002956 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 633699002957 recombination factor protein RarA; Reviewed; Region: PRK13342 633699002958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699002959 Walker A motif; other site 633699002960 ATP binding site [chemical binding]; other site 633699002961 Walker B motif; other site 633699002962 arginine finger; other site 633699002963 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 633699002964 TIGR02687 family protein; Region: TIGR02687 633699002965 PglZ domain; Region: PglZ; pfam08665 633699002966 hypothetical protein; Provisional; Region: PRK06194 633699002967 classical (c) SDRs; Region: SDR_c; cd05233 633699002968 NAD(P) binding site [chemical binding]; other site 633699002969 active site 633699002970 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 633699002971 dimer interface [polypeptide binding]; other site 633699002972 FMN binding site [chemical binding]; other site 633699002973 Transcriptional regulator [Transcription]; Region: LysR; COG0583 633699002974 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 633699002975 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 633699002976 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 633699002977 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 633699002978 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 633699002979 recombination factor protein RarA; Reviewed; Region: PRK13342 633699002980 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 633699002981 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 633699002982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633699002983 Coenzyme A binding pocket [chemical binding]; other site 633699002984 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 633699002985 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 633699002986 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 633699002987 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699002988 ATP binding site [chemical binding]; other site 633699002989 putative Mg++ binding site [ion binding]; other site 633699002990 Uncharacterized conserved protein [Function unknown]; Region: COG1479 633699002991 Protein of unknown function DUF262; Region: DUF262; pfam03235 633699002992 Protein of unknown function DUF262; Region: DUF262; pfam03235 633699002993 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 633699002994 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 633699002995 Interdomain contacts; other site 633699002996 Cytokine receptor motif; other site 633699002997 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699002998 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 633699002999 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 633699003000 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 633699003001 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 633699003002 Cupin domain; Region: Cupin_2; cl17218 633699003003 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 633699003004 dimer interface [polypeptide binding]; other site 633699003005 catalytic triad [active] 633699003006 peroxidatic and resolving cysteines [active] 633699003007 Uncharacterized conserved protein [Function unknown]; Region: COG1359 633699003008 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 633699003009 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 633699003010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699003011 Walker A/P-loop; other site 633699003012 ATP binding site [chemical binding]; other site 633699003013 Q-loop/lid; other site 633699003014 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 633699003015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699003016 ABC transporter signature motif; other site 633699003017 Walker B; other site 633699003018 D-loop; other site 633699003019 H-loop/switch region; other site 633699003020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699003021 AAA domain; Region: AAA_21; pfam13304 633699003022 Walker A/P-loop; other site 633699003023 ATP binding site [chemical binding]; other site 633699003024 Q-loop/lid; other site 633699003025 ABC transporter signature motif; other site 633699003026 Walker B; other site 633699003027 D-loop; other site 633699003028 H-loop/switch region; other site 633699003029 NTP-binding motif containing protein; Region: PHA00729 633699003030 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 633699003031 Walker A motif; other site 633699003032 ATP binding site [chemical binding]; other site 633699003033 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 633699003034 active site 633699003035 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 633699003036 active site 633699003037 Methyltransferase domain; Region: Methyltransf_23; pfam13489 633699003038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699003039 S-adenosylmethionine binding site [chemical binding]; other site 633699003040 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 633699003041 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 633699003042 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 633699003043 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 633699003044 aromatic amino acid aminotransferase; Validated; Region: PRK07309 633699003045 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 633699003046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633699003047 homodimer interface [polypeptide binding]; other site 633699003048 catalytic residue [active] 633699003049 dihydrodipicolinate reductase; Provisional; Region: PRK00048 633699003050 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 633699003051 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 633699003052 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 633699003053 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 633699003054 dimer interface [polypeptide binding]; other site 633699003055 active site 633699003056 catalytic residue [active] 633699003057 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 633699003058 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 633699003059 metal binding site [ion binding]; metal-binding site 633699003060 putative dimer interface [polypeptide binding]; other site 633699003061 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 633699003062 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 633699003063 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 633699003064 putative trimer interface [polypeptide binding]; other site 633699003065 putative CoA binding site [chemical binding]; other site 633699003066 diaminopimelate decarboxylase; Region: lysA; TIGR01048 633699003067 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 633699003068 active site 633699003069 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 633699003070 substrate binding site [chemical binding]; other site 633699003071 catalytic residues [active] 633699003072 dimer interface [polypeptide binding]; other site 633699003073 aspartate kinase; Reviewed; Region: PRK09034 633699003074 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 633699003075 putative catalytic residues [active] 633699003076 putative nucleotide binding site [chemical binding]; other site 633699003077 putative aspartate binding site [chemical binding]; other site 633699003078 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 633699003079 allosteric regulatory residue; other site 633699003080 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 633699003081 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 633699003082 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 633699003083 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 633699003084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 633699003085 Transposase; Region: DDE_Tnp_ISL3; pfam01610 633699003086 Transposase; Region: DDE_Tnp_ISL3; pfam01610 633699003087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 633699003088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 633699003089 Transposase; Region: DEDD_Tnp_IS110; pfam01548 633699003090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 633699003091 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 633699003092 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 633699003093 MucBP domain; Region: MucBP; pfam06458 633699003094 MucBP domain; Region: MucBP; pfam06458 633699003095 MucBP domain; Region: MucBP; pfam06458 633699003096 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 633699003097 Transposase; Region: DDE_Tnp_ISL3; pfam01610 633699003098 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 633699003099 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 633699003100 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 633699003101 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 633699003102 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 633699003103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633699003104 dimer interface [polypeptide binding]; other site 633699003105 phosphorylation site [posttranslational modification] 633699003106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633699003107 Mg2+ binding site [ion binding]; other site 633699003108 G-X-G motif; other site 633699003109 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 633699003110 Response regulator receiver domain; Region: Response_reg; pfam00072 633699003111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633699003112 active site 633699003113 phosphorylation site [posttranslational modification] 633699003114 intermolecular recognition site; other site 633699003115 dimerization interface [polypeptide binding]; other site 633699003116 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633699003117 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 633699003118 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 633699003119 nudix motif; other site 633699003120 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 633699003121 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699003122 motif II; other site 633699003123 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 633699003124 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 633699003125 active site 633699003126 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 633699003127 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 633699003128 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 633699003129 acetolactate synthase; Reviewed; Region: PRK08617 633699003130 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 633699003131 PYR/PP interface [polypeptide binding]; other site 633699003132 dimer interface [polypeptide binding]; other site 633699003133 TPP binding site [chemical binding]; other site 633699003134 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 633699003135 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 633699003136 TPP-binding site [chemical binding]; other site 633699003137 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 633699003138 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 633699003139 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633699003140 ABC transporter; Region: ABC_tran_2; pfam12848 633699003141 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633699003142 Predicted membrane protein [Function unknown]; Region: COG2855 633699003143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 633699003144 Probable transposase; Region: OrfB_IS605; pfam01385 633699003145 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 633699003146 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 633699003147 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 633699003148 dimerization interface [polypeptide binding]; other site 633699003149 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 633699003150 active site 633699003151 catalytic residues [active] 633699003152 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 633699003153 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699003154 Walker A motif; other site 633699003155 ATP binding site [chemical binding]; other site 633699003156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699003157 Walker B motif; other site 633699003158 arginine finger; other site 633699003159 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 633699003160 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 633699003161 active site 633699003162 HslU subunit interaction site [polypeptide binding]; other site 633699003163 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 633699003164 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 633699003165 active site 633699003166 Int/Topo IB signature motif; other site 633699003167 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 633699003168 Glucose inhibited division protein A; Region: GIDA; pfam01134 633699003169 DNA topoisomerase I; Validated; Region: PRK05582 633699003170 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 633699003171 active site 633699003172 interdomain interaction site; other site 633699003173 putative metal-binding site [ion binding]; other site 633699003174 nucleotide binding site [chemical binding]; other site 633699003175 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 633699003176 domain I; other site 633699003177 DNA binding groove [nucleotide binding] 633699003178 phosphate binding site [ion binding]; other site 633699003179 domain II; other site 633699003180 domain III; other site 633699003181 nucleotide binding site [chemical binding]; other site 633699003182 catalytic site [active] 633699003183 domain IV; other site 633699003184 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 633699003185 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 633699003186 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 633699003187 DNA protecting protein DprA; Region: dprA; TIGR00732 633699003188 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 633699003189 RNA/DNA hybrid binding site [nucleotide binding]; other site 633699003190 active site 633699003191 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 633699003192 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 633699003193 GTP/Mg2+ binding site [chemical binding]; other site 633699003194 G4 box; other site 633699003195 G5 box; other site 633699003196 G1 box; other site 633699003197 Switch I region; other site 633699003198 G2 box; other site 633699003199 G3 box; other site 633699003200 Switch II region; other site 633699003201 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 633699003202 C-terminal peptidase (prc); Region: prc; TIGR00225 633699003203 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 633699003204 protein binding site [polypeptide binding]; other site 633699003205 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 633699003206 Catalytic dyad [active] 633699003207 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 633699003208 hypothetical protein; Provisional; Region: PRK13672 633699003209 EDD domain protein, DegV family; Region: DegV; TIGR00762 633699003210 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 633699003211 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 633699003212 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 633699003213 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 633699003214 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 633699003215 active site 633699003216 NTP binding site [chemical binding]; other site 633699003217 metal binding triad [ion binding]; metal-binding site 633699003218 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 633699003219 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 633699003220 Uncharacterized conserved protein [Function unknown]; Region: COG1284 633699003221 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 633699003222 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 633699003223 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 633699003224 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 633699003225 UbiA prenyltransferase family; Region: UbiA; pfam01040 633699003226 Predicted oxidoreductase [General function prediction only]; Region: COG3573 633699003227 hypothetical protein; Validated; Region: PRK07121 633699003228 Predicted oxidoreductase [General function prediction only]; Region: COG3573 633699003229 Transcriptional regulator [Transcription]; Region: LysR; COG0583 633699003230 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 633699003231 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 633699003232 dimerization interface [polypeptide binding]; other site 633699003233 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 633699003234 Transposase; Region: DDE_Tnp_ISL3; pfam01610 633699003235 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 633699003236 T5orf172 domain; Region: T5orf172; cl17462 633699003237 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 633699003238 DEAD-like helicases superfamily; Region: DEXDc; smart00487 633699003239 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699003240 ATP binding site [chemical binding]; other site 633699003241 putative Mg++ binding site [ion binding]; other site 633699003242 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 633699003243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 633699003244 binding surface 633699003245 TPR motif; other site 633699003246 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 633699003247 binding surface 633699003248 TPR motif; other site 633699003249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 633699003250 binding surface 633699003251 TPR motif; other site 633699003252 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 633699003253 IHF dimer interface [polypeptide binding]; other site 633699003254 IHF - DNA interface [nucleotide binding]; other site 633699003255 GTP-binding protein Der; Reviewed; Region: PRK00093 633699003256 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 633699003257 G1 box; other site 633699003258 GTP/Mg2+ binding site [chemical binding]; other site 633699003259 Switch I region; other site 633699003260 G2 box; other site 633699003261 Switch II region; other site 633699003262 G3 box; other site 633699003263 G4 box; other site 633699003264 G5 box; other site 633699003265 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 633699003266 G1 box; other site 633699003267 GTP/Mg2+ binding site [chemical binding]; other site 633699003268 Switch I region; other site 633699003269 G2 box; other site 633699003270 G3 box; other site 633699003271 Switch II region; other site 633699003272 G4 box; other site 633699003273 G5 box; other site 633699003274 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 633699003275 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 633699003276 RNA binding site [nucleotide binding]; other site 633699003277 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 633699003278 RNA binding site [nucleotide binding]; other site 633699003279 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 633699003280 RNA binding site [nucleotide binding]; other site 633699003281 cytidylate kinase; Provisional; Region: cmk; PRK00023 633699003282 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 633699003283 CMP-binding site; other site 633699003284 The sites determining sugar specificity; other site 633699003285 Predicted membrane protein [Function unknown]; Region: COG3601 633699003286 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 633699003287 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 633699003288 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 633699003289 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633699003290 RNA binding surface [nucleotide binding]; other site 633699003291 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 633699003292 active site 633699003293 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 633699003294 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 633699003295 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 633699003296 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 633699003297 active site 633699003298 Int/Topo IB signature motif; other site 633699003299 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 633699003300 S1 domain; Region: S1_2; pfam13509 633699003301 pyruvate kinase; Provisional; Region: PRK06354 633699003302 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 633699003303 domain interfaces; other site 633699003304 active site 633699003305 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 633699003306 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 633699003307 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 633699003308 active site 633699003309 ADP/pyrophosphate binding site [chemical binding]; other site 633699003310 dimerization interface [polypeptide binding]; other site 633699003311 allosteric effector site; other site 633699003312 fructose-1,6-bisphosphate binding site; other site 633699003313 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 633699003314 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 633699003315 active site 633699003316 PHP Thumb interface [polypeptide binding]; other site 633699003317 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 633699003318 generic binding surface II; other site 633699003319 generic binding surface I; other site 633699003320 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 633699003321 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 633699003322 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 633699003323 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 633699003324 active site 633699003325 metal binding site [ion binding]; metal-binding site 633699003326 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 633699003327 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 633699003328 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 633699003329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699003330 NAD(P) binding site [chemical binding]; other site 633699003331 active site 633699003332 ribonuclease Z; Region: RNase_Z; TIGR02651 633699003333 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 633699003334 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 633699003335 catalytic triad [active] 633699003336 catalytic triad [active] 633699003337 oxyanion hole [active] 633699003338 GTPase CgtA; Reviewed; Region: obgE; PRK12297 633699003339 GTP1/OBG; Region: GTP1_OBG; pfam01018 633699003340 Obg GTPase; Region: Obg; cd01898 633699003341 G1 box; other site 633699003342 GTP/Mg2+ binding site [chemical binding]; other site 633699003343 Switch I region; other site 633699003344 G2 box; other site 633699003345 G3 box; other site 633699003346 Switch II region; other site 633699003347 G4 box; other site 633699003348 G5 box; other site 633699003349 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 633699003350 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 633699003351 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 633699003352 GIY-YIG motif/motif A; other site 633699003353 active site 633699003354 catalytic site [active] 633699003355 putative DNA binding site [nucleotide binding]; other site 633699003356 metal binding site [ion binding]; metal-binding site 633699003357 UvrB/uvrC motif; Region: UVR; pfam02151 633699003358 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 633699003359 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 633699003360 DNA binding site [nucleotide binding] 633699003361 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 633699003362 active site 633699003363 dimerization interface [polypeptide binding]; other site 633699003364 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 633699003365 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 633699003366 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 633699003367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699003368 NADH(P)-binding; Region: NAD_binding_10; pfam13460 633699003369 NAD(P) binding site [chemical binding]; other site 633699003370 active site 633699003371 amino acid transporter; Region: 2A0306; TIGR00909 633699003372 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 633699003373 Rib/alpha-like repeat; Region: Rib; pfam08428 633699003374 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 633699003375 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 633699003376 putative active site [active] 633699003377 nucleotide binding site [chemical binding]; other site 633699003378 nudix motif; other site 633699003379 putative metal binding site [ion binding]; other site 633699003380 Bacterial SH3 domain; Region: SH3_5; pfam08460 633699003381 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 633699003382 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 633699003383 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 633699003384 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 633699003385 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 633699003386 Int/Topo IB signature motif; other site 633699003387 Peptidase family M48; Region: Peptidase_M48; cl12018 633699003388 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 633699003389 putative active site [active] 633699003390 putative NTP binding site [chemical binding]; other site 633699003391 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 633699003392 putative nucleic acid binding site [nucleotide binding]; other site 633699003393 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 633699003394 Integrase core domain; Region: rve; pfam00665 633699003395 Domain of unknown function (DUF1919); Region: DUF1919; cl01628 633699003396 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 633699003397 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 633699003398 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 633699003399 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 633699003400 UDP-galactopyranose mutase; Region: GLF; pfam03275 633699003401 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 633699003402 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 633699003403 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 633699003404 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 633699003405 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 633699003406 active site 633699003407 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 633699003408 active site 633699003409 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 633699003410 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 633699003411 putative ADP-binding pocket [chemical binding]; other site 633699003412 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 633699003413 Bacterial sugar transferase; Region: Bac_transf; pfam02397 633699003414 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 633699003415 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 633699003416 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 633699003417 Chain length determinant protein; Region: Wzz; cl15801 633699003418 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 633699003419 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 633699003420 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 633699003421 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 633699003422 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 633699003423 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 633699003424 Low molecular weight phosphatase family; Region: LMWPc; cd00115 633699003425 active site 633699003426 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 633699003427 G1 box; other site 633699003428 GTP/Mg2+ binding site [chemical binding]; other site 633699003429 Switch I region; other site 633699003430 G2 box; other site 633699003431 G3 box; other site 633699003432 Switch II region; other site 633699003433 G4 box; other site 633699003434 G5 box; other site 633699003435 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 633699003436 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 633699003437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699003438 Walker A motif; other site 633699003439 ATP binding site [chemical binding]; other site 633699003440 Walker B motif; other site 633699003441 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 633699003442 trigger factor; Provisional; Region: tig; PRK01490 633699003443 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 633699003444 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 633699003445 elongation factor Tu; Reviewed; Region: PRK00049 633699003446 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 633699003447 G1 box; other site 633699003448 GEF interaction site [polypeptide binding]; other site 633699003449 GTP/Mg2+ binding site [chemical binding]; other site 633699003450 Switch I region; other site 633699003451 G2 box; other site 633699003452 G3 box; other site 633699003453 Switch II region; other site 633699003454 G4 box; other site 633699003455 G5 box; other site 633699003456 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 633699003457 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 633699003458 Antibiotic Binding Site [chemical binding]; other site 633699003459 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 633699003460 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 633699003461 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 633699003462 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 633699003463 16S/18S rRNA binding site [nucleotide binding]; other site 633699003464 S13e-L30e interaction site [polypeptide binding]; other site 633699003465 25S rRNA binding site [nucleotide binding]; other site 633699003466 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 633699003467 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 633699003468 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 633699003469 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 633699003470 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 633699003471 Competence protein; Region: Competence; pfam03772 633699003472 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 633699003473 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 633699003474 SLBB domain; Region: SLBB; pfam10531 633699003475 comEA protein; Region: comE; TIGR01259 633699003476 Helix-hairpin-helix motif; Region: HHH; pfam00633 633699003477 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 633699003478 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 633699003479 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 633699003480 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 633699003481 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 633699003482 active site 633699003483 (T/H)XGH motif; other site 633699003484 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 633699003485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699003486 S-adenosylmethionine binding site [chemical binding]; other site 633699003487 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 633699003488 cell division protein FtsW; Region: ftsW; TIGR02614 633699003489 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 633699003490 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 633699003491 putative GEF interaction site [polypeptide binding]; other site 633699003492 G1 box; other site 633699003493 GTP/Mg2+ binding site [chemical binding]; other site 633699003494 Switch I region; other site 633699003495 G2 box; other site 633699003496 G3 box; other site 633699003497 Switch II region; other site 633699003498 G4 box; other site 633699003499 G5 box; other site 633699003500 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 633699003501 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 633699003502 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 633699003503 active site 633699003504 catalytic residues [active] 633699003505 metal binding site [ion binding]; metal-binding site 633699003506 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 633699003507 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 633699003508 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 633699003509 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 633699003510 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 633699003511 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 633699003512 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 633699003513 AAA domain; Region: AAA_30; pfam13604 633699003514 Family description; Region: UvrD_C_2; pfam13538 633699003515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 633699003516 binding surface 633699003517 TPR motif; other site 633699003518 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 633699003519 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699003520 catalytic core [active] 633699003521 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 633699003522 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 633699003523 Putative amino acid metabolism; Region: DUF1831; pfam08866 633699003524 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 633699003525 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 633699003526 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 633699003527 catalytic residue [active] 633699003528 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 633699003529 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 633699003530 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 633699003531 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 633699003532 dimer interface [polypeptide binding]; other site 633699003533 ADP-ribose binding site [chemical binding]; other site 633699003534 active site 633699003535 nudix motif; other site 633699003536 metal binding site [ion binding]; metal-binding site 633699003537 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 633699003538 DNA-binding site [nucleotide binding]; DNA binding site 633699003539 RNA-binding motif; other site 633699003540 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 633699003541 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 633699003542 active site 633699003543 HIGH motif; other site 633699003544 nucleotide binding site [chemical binding]; other site 633699003545 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 633699003546 active site 633699003547 KMSKS motif; other site 633699003548 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 633699003549 tRNA binding surface [nucleotide binding]; other site 633699003550 anticodon binding site; other site 633699003551 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 633699003552 DivIVA protein; Region: DivIVA; pfam05103 633699003553 DivIVA domain; Region: DivI1A_domain; TIGR03544 633699003554 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 633699003555 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 633699003556 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633699003557 RNA binding surface [nucleotide binding]; other site 633699003558 YGGT family; Region: YGGT; pfam02325 633699003559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 633699003560 cell division protein FtsZ; Validated; Region: PRK09330 633699003561 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 633699003562 nucleotide binding site [chemical binding]; other site 633699003563 SulA interaction site; other site 633699003564 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 633699003565 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 633699003566 nucleotide binding site [chemical binding]; other site 633699003567 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 633699003568 Cell division protein FtsA; Region: FtsA; pfam14450 633699003569 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 633699003570 Cell division protein FtsQ; Region: FtsQ; pfam03799 633699003571 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 633699003572 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 633699003573 active site 633699003574 homodimer interface [polypeptide binding]; other site 633699003575 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 633699003576 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 633699003577 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 633699003578 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 633699003579 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 633699003580 Mg++ binding site [ion binding]; other site 633699003581 putative catalytic motif [active] 633699003582 putative substrate binding site [chemical binding]; other site 633699003583 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 633699003584 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 633699003585 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 633699003586 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 633699003587 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 633699003588 cell division protein FtsL; Region: ftsL_broad; TIGR02209 633699003589 MraW methylase family; Region: Methyltransf_5; pfam01795 633699003590 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 633699003591 cell division protein MraZ; Reviewed; Region: PRK00326 633699003592 MraZ protein; Region: MraZ; pfam02381 633699003593 MraZ protein; Region: MraZ; pfam02381 633699003594 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 633699003595 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 633699003596 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 633699003597 rod shape-determining protein MreC; Provisional; Region: PRK13922 633699003598 rod shape-determining protein MreC; Region: MreC; pfam04085 633699003599 rod shape-determining protein MreB; Provisional; Region: PRK13927 633699003600 MreB and similar proteins; Region: MreB_like; cd10225 633699003601 nucleotide binding site [chemical binding]; other site 633699003602 Mg binding site [ion binding]; other site 633699003603 putative protofilament interaction site [polypeptide binding]; other site 633699003604 RodZ interaction site [polypeptide binding]; other site 633699003605 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 633699003606 MPN+ (JAMM) motif; other site 633699003607 Zinc-binding site [ion binding]; other site 633699003608 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 633699003609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699003610 motif II; other site 633699003611 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 633699003612 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 633699003613 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 633699003614 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 633699003615 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 633699003616 active site 633699003617 HIGH motif; other site 633699003618 nucleotide binding site [chemical binding]; other site 633699003619 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 633699003620 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 633699003621 active site 633699003622 KMSKS motif; other site 633699003623 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 633699003624 tRNA binding surface [nucleotide binding]; other site 633699003625 anticodon binding site; other site 633699003626 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 633699003627 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 633699003628 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 633699003629 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699003630 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 633699003631 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699003632 motif II; other site 633699003633 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 633699003634 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 633699003635 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 633699003636 active site 633699003637 catalytic site [active] 633699003638 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 633699003639 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633699003640 RNA binding surface [nucleotide binding]; other site 633699003641 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 633699003642 active site 633699003643 uracil binding [chemical binding]; other site 633699003644 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 633699003645 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 633699003646 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 633699003647 Ligand Binding Site [chemical binding]; other site 633699003648 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 633699003649 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 633699003650 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 633699003651 catalytic residue [active] 633699003652 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 633699003653 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 633699003654 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 633699003655 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 633699003656 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633699003657 RNA binding surface [nucleotide binding]; other site 633699003658 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 633699003659 recombination factor protein RarA; Reviewed; Region: PRK13342 633699003660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699003661 Walker A motif; other site 633699003662 ATP binding site [chemical binding]; other site 633699003663 Walker B motif; other site 633699003664 arginine finger; other site 633699003665 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 633699003666 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 633699003667 Ligand Binding Site [chemical binding]; other site 633699003668 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 633699003669 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 633699003670 hypothetical protein; Provisional; Region: PRK14379 633699003671 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 633699003672 rod shape-determining protein MreB; Provisional; Region: PRK13930 633699003673 MreB and similar proteins; Region: MreB_like; cd10225 633699003674 nucleotide binding site [chemical binding]; other site 633699003675 Mg binding site [ion binding]; other site 633699003676 putative protofilament interaction site [polypeptide binding]; other site 633699003677 RodZ interaction site [polypeptide binding]; other site 633699003678 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 633699003679 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 633699003680 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 633699003681 gamma subunit interface [polypeptide binding]; other site 633699003682 epsilon subunit interface [polypeptide binding]; other site 633699003683 LBP interface [polypeptide binding]; other site 633699003684 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 633699003685 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 633699003686 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 633699003687 alpha subunit interaction interface [polypeptide binding]; other site 633699003688 Walker A motif; other site 633699003689 ATP binding site [chemical binding]; other site 633699003690 Walker B motif; other site 633699003691 inhibitor binding site; inhibition site 633699003692 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 633699003693 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 633699003694 core domain interface [polypeptide binding]; other site 633699003695 delta subunit interface [polypeptide binding]; other site 633699003696 epsilon subunit interface [polypeptide binding]; other site 633699003697 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 633699003698 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 633699003699 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 633699003700 beta subunit interaction interface [polypeptide binding]; other site 633699003701 Walker A motif; other site 633699003702 ATP binding site [chemical binding]; other site 633699003703 Walker B motif; other site 633699003704 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 633699003705 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 633699003706 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 633699003707 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 633699003708 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 633699003709 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 633699003710 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 633699003711 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699003712 active site 633699003713 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 633699003714 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 633699003715 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 633699003716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699003717 S-adenosylmethionine binding site [chemical binding]; other site 633699003718 peptide chain release factor 1; Validated; Region: prfA; PRK00591 633699003719 This domain is found in peptide chain release factors; Region: PCRF; smart00937 633699003720 RF-1 domain; Region: RF-1; pfam00472 633699003721 thymidine kinase; Provisional; Region: PRK04296 633699003722 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 633699003723 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 633699003724 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 633699003725 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 633699003726 Beta-lactamase; Region: Beta-lactamase; pfam00144 633699003727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699003728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 633699003729 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 633699003730 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 633699003731 active site 633699003732 dimer interface [polypeptide binding]; other site 633699003733 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 633699003734 dimer interface [polypeptide binding]; other site 633699003735 active site 633699003736 VanZ like family; Region: VanZ; cl01971 633699003737 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 633699003738 Sulfatase; Region: Sulfatase; pfam00884 633699003739 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 633699003740 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 633699003741 dimerization interface [polypeptide binding]; other site 633699003742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633699003743 dimer interface [polypeptide binding]; other site 633699003744 phosphorylation site [posttranslational modification] 633699003745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633699003746 ATP binding site [chemical binding]; other site 633699003747 Mg2+ binding site [ion binding]; other site 633699003748 G-X-G motif; other site 633699003749 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633699003750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633699003751 active site 633699003752 phosphorylation site [posttranslational modification] 633699003753 intermolecular recognition site; other site 633699003754 dimerization interface [polypeptide binding]; other site 633699003755 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633699003756 DNA binding site [nucleotide binding] 633699003757 SdpI/YhfL protein family; Region: SdpI; pfam13630 633699003758 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 633699003759 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 633699003760 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 633699003761 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 633699003762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633699003763 homodimer interface [polypeptide binding]; other site 633699003764 catalytic residue [active] 633699003765 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 633699003766 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 633699003767 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 633699003768 active site 633699003769 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 633699003770 propionate/acetate kinase; Provisional; Region: PRK12379 633699003771 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 633699003772 Methyltransferase domain; Region: Methyltransf_26; pfam13659 633699003773 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 633699003774 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 633699003775 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 633699003776 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 633699003777 Type II/IV secretion system protein; Region: T2SE; pfam00437 633699003778 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 633699003779 Walker A motif; other site 633699003780 ATP binding site [chemical binding]; other site 633699003781 Walker B motif; other site 633699003782 hypothetical protein; Validated; Region: PRK00110 633699003783 Predicted integral membrane protein [Function unknown]; Region: COG5652 633699003784 Flavoprotein; Region: Flavoprotein; pfam02441 633699003785 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 633699003786 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 633699003787 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 633699003788 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 633699003789 intersubunit interface [polypeptide binding]; other site 633699003790 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 633699003791 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 633699003792 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 633699003793 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 633699003794 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 633699003795 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 633699003796 camphor resistance protein CrcB; Provisional; Region: PRK14220 633699003797 CrcB-like protein; Region: CRCB; pfam02537 633699003798 sugar phosphate phosphatase; Provisional; Region: PRK10513 633699003799 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699003800 active site 633699003801 motif I; other site 633699003802 motif II; other site 633699003803 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 633699003804 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 633699003805 active site 633699003806 substrate binding site [chemical binding]; other site 633699003807 metal binding site [ion binding]; metal-binding site 633699003808 YbbR-like protein; Region: YbbR; pfam07949 633699003809 YbbR-like protein; Region: YbbR; pfam07949 633699003810 YbbR-like protein; Region: YbbR; pfam07949 633699003811 Uncharacterized conserved protein [Function unknown]; Region: COG1624 633699003812 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 633699003813 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 633699003814 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 633699003815 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 633699003816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699003817 dimer interface [polypeptide binding]; other site 633699003818 ABC-ATPase subunit interface; other site 633699003819 putative PBP binding loops; other site 633699003820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699003821 dimer interface [polypeptide binding]; other site 633699003822 conserved gate region; other site 633699003823 putative PBP binding loops; other site 633699003824 ABC-ATPase subunit interface; other site 633699003825 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 633699003826 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 633699003827 Walker A/P-loop; other site 633699003828 ATP binding site [chemical binding]; other site 633699003829 Q-loop/lid; other site 633699003830 ABC transporter signature motif; other site 633699003831 Walker B; other site 633699003832 D-loop; other site 633699003833 H-loop/switch region; other site 633699003834 TOBE domain; Region: TOBE_2; pfam08402 633699003835 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 633699003836 FAD binding domain; Region: FAD_binding_4; pfam01565 633699003837 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 633699003838 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 633699003839 active site 633699003840 catalytic site [active] 633699003841 substrate binding site [chemical binding]; other site 633699003842 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 633699003843 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 633699003844 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 633699003845 ligand binding site [chemical binding]; other site 633699003846 active site 633699003847 UGI interface [polypeptide binding]; other site 633699003848 catalytic site [active] 633699003849 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699003850 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633699003851 active site 633699003852 motif I; other site 633699003853 motif II; other site 633699003854 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 633699003855 Tubby C 2; Region: Tub_2; cl02043 633699003856 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633699003857 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 633699003858 Coenzyme A binding pocket [chemical binding]; other site 633699003859 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 633699003860 SmpB-tmRNA interface; other site 633699003861 ribonuclease R; Region: RNase_R; TIGR02063 633699003862 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 633699003863 RNB domain; Region: RNB; pfam00773 633699003864 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 633699003865 RNA binding site [nucleotide binding]; other site 633699003866 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 633699003867 enolase; Provisional; Region: eno; PRK00077 633699003868 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 633699003869 dimer interface [polypeptide binding]; other site 633699003870 metal binding site [ion binding]; metal-binding site 633699003871 substrate binding pocket [chemical binding]; other site 633699003872 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 633699003873 triosephosphate isomerase; Provisional; Region: PRK14567 633699003874 substrate binding site [chemical binding]; other site 633699003875 dimer interface [polypeptide binding]; other site 633699003876 catalytic triad [active] 633699003877 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 633699003878 Phosphoglycerate kinase; Region: PGK; pfam00162 633699003879 substrate binding site [chemical binding]; other site 633699003880 hinge regions; other site 633699003881 ADP binding site [chemical binding]; other site 633699003882 catalytic site [active] 633699003883 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 633699003884 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 633699003885 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 633699003886 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 633699003887 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 633699003888 Amino acid permease; Region: AA_permease_2; pfam13520 633699003889 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 633699003890 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 633699003891 oligomer interface [polypeptide binding]; other site 633699003892 active site residues [active] 633699003893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 633699003894 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 633699003895 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 633699003896 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 633699003897 phosphate binding site [ion binding]; other site 633699003898 putative substrate binding pocket [chemical binding]; other site 633699003899 dimer interface [polypeptide binding]; other site 633699003900 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 633699003901 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 633699003902 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 633699003903 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 633699003904 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 633699003905 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 633699003906 excinuclease ABC subunit B; Provisional; Region: PRK05298 633699003907 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 633699003908 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699003909 ATP-binding site [chemical binding]; other site 633699003910 ATP binding site [chemical binding]; other site 633699003911 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699003912 nucleotide binding region [chemical binding]; other site 633699003913 ATP-binding site [chemical binding]; other site 633699003914 Ultra-violet resistance protein B; Region: UvrB; pfam12344 633699003915 UvrB/uvrC motif; Region: UVR; pfam02151 633699003916 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 633699003917 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 633699003918 active site 633699003919 substrate binding site [chemical binding]; other site 633699003920 metal binding site [ion binding]; metal-binding site 633699003921 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 633699003922 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 633699003923 catalytic residues [active] 633699003924 catalytic residues [active] 633699003925 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 633699003926 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 633699003927 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 633699003928 galactokinase; Provisional; Region: PRK05322 633699003929 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 633699003930 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 633699003931 Transcriptional regulators [Transcription]; Region: PurR; COG1609 633699003932 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 633699003933 DNA binding site [nucleotide binding] 633699003934 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 633699003935 putative ligand binding site [chemical binding]; other site 633699003936 putative dimerization interface [polypeptide binding]; other site 633699003937 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 633699003938 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 633699003939 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 633699003940 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 633699003941 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 633699003942 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 633699003943 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 633699003944 HPr kinase/phosphorylase; Provisional; Region: PRK05428 633699003945 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 633699003946 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 633699003947 Hpr binding site; other site 633699003948 active site 633699003949 homohexamer subunit interaction site [polypeptide binding]; other site 633699003950 peptide chain release factor 2; Provisional; Region: PRK05589 633699003951 This domain is found in peptide chain release factors; Region: PCRF; smart00937 633699003952 RF-1 domain; Region: RF-1; pfam00472 633699003953 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 633699003954 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 633699003955 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699003956 nucleotide binding region [chemical binding]; other site 633699003957 ATP-binding site [chemical binding]; other site 633699003958 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 633699003959 30S subunit binding site; other site 633699003960 comF family protein; Region: comF; TIGR00201 633699003961 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699003962 active site 633699003963 DEAD-like helicases superfamily; Region: DEXDc; smart00487 633699003964 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699003965 ATP binding site [chemical binding]; other site 633699003966 putative Mg++ binding site [ion binding]; other site 633699003967 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699003968 nucleotide binding region [chemical binding]; other site 633699003969 ATP-binding site [chemical binding]; other site 633699003970 Uncharacterized conserved protein [Function unknown]; Region: COG1739 633699003971 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 633699003972 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 633699003973 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 633699003974 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 633699003975 Mg++ binding site [ion binding]; other site 633699003976 putative catalytic motif [active] 633699003977 substrate binding site [chemical binding]; other site 633699003978 phosphodiesterase; Provisional; Region: PRK12704 633699003979 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633699003980 Zn2+ binding site [ion binding]; other site 633699003981 Mg2+ binding site [ion binding]; other site 633699003982 recombinase A; Provisional; Region: recA; PRK09354 633699003983 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 633699003984 hexamer interface [polypeptide binding]; other site 633699003985 Walker A motif; other site 633699003986 ATP binding site [chemical binding]; other site 633699003987 Walker B motif; other site 633699003988 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 633699003989 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 633699003990 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633699003991 non-specific DNA binding site [nucleotide binding]; other site 633699003992 salt bridge; other site 633699003993 sequence-specific DNA binding site [nucleotide binding]; other site 633699003994 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 633699003995 classical (c) SDRs; Region: SDR_c; cd05233 633699003996 NAD(P) binding site [chemical binding]; other site 633699003997 active site 633699003998 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 633699003999 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 633699004000 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 633699004001 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 633699004002 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 633699004003 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 633699004004 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 633699004005 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 633699004006 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 633699004007 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 633699004008 Domain of unknown function DUF20; Region: UPF0118; pfam01594 633699004009 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 633699004010 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 633699004011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699004012 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 633699004013 Walker A motif; other site 633699004014 ATP binding site [chemical binding]; other site 633699004015 Walker B motif; other site 633699004016 arginine finger; other site 633699004017 Uncharacterized conserved protein [Function unknown]; Region: COG3410 633699004018 myosin-cross-reactive antigen; Provisional; Region: PRK13977 633699004019 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 633699004020 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 633699004021 active site 633699004022 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 633699004023 ATP-NAD kinase; Region: NAD_kinase; pfam01513 633699004024 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 633699004025 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 633699004026 synthetase active site [active] 633699004027 NTP binding site [chemical binding]; other site 633699004028 metal binding site [ion binding]; metal-binding site 633699004029 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 633699004030 putative active site [active] 633699004031 putative metal binding residues [ion binding]; other site 633699004032 signature motif; other site 633699004033 putative triphosphate binding site [ion binding]; other site 633699004034 Thioredoxin; Region: Thioredoxin_5; pfam13743 633699004035 Competence protein CoiA-like family; Region: CoiA; cl11541 633699004036 adaptor protein; Provisional; Region: PRK02315 633699004037 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 633699004038 ArsC family; Region: ArsC; pfam03960 633699004039 putative catalytic residues [active] 633699004040 thiol/disulfide switch; other site 633699004041 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 633699004042 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 633699004043 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 633699004044 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 633699004045 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 633699004046 dimerization domain swap beta strand [polypeptide binding]; other site 633699004047 regulatory protein interface [polypeptide binding]; other site 633699004048 active site 633699004049 regulatory phosphorylation site [posttranslational modification]; other site 633699004050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699004051 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 633699004052 Walker A motif; other site 633699004053 ATP binding site [chemical binding]; other site 633699004054 Walker B motif; other site 633699004055 arginine finger; other site 633699004056 UvrB/uvrC motif; Region: UVR; pfam02151 633699004057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699004058 Walker A motif; other site 633699004059 ATP binding site [chemical binding]; other site 633699004060 Walker B motif; other site 633699004061 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 633699004062 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 633699004063 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 633699004064 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 633699004065 G1 box; other site 633699004066 putative GEF interaction site [polypeptide binding]; other site 633699004067 GTP/Mg2+ binding site [chemical binding]; other site 633699004068 Switch I region; other site 633699004069 G2 box; other site 633699004070 G3 box; other site 633699004071 Switch II region; other site 633699004072 G4 box; other site 633699004073 G5 box; other site 633699004074 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 633699004075 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 633699004076 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 633699004077 Transporter associated domain; Region: CorC_HlyC; pfam03471 633699004078 hypothetical protein; Provisional; Region: PRK13662 633699004079 recombination regulator RecX; Provisional; Region: recX; PRK14135 633699004080 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 633699004081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699004082 S-adenosylmethionine binding site [chemical binding]; other site 633699004083 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 633699004084 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 633699004085 dimer interface [polypeptide binding]; other site 633699004086 active site 633699004087 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 633699004088 homodimer interface [polypeptide binding]; other site 633699004089 catalytic residues [active] 633699004090 NAD binding site [chemical binding]; other site 633699004091 substrate binding pocket [chemical binding]; other site 633699004092 flexible flap; other site 633699004093 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 633699004094 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 633699004095 dimer interface [polypeptide binding]; other site 633699004096 active site 633699004097 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 633699004098 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 633699004099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699004100 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633699004101 active site 633699004102 motif I; other site 633699004103 motif II; other site 633699004104 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 633699004105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699004106 putative substrate translocation pore; other site 633699004107 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633699004108 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 633699004109 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 633699004110 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 633699004111 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 633699004112 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 633699004113 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 633699004114 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 633699004115 active site residue [active] 633699004116 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 633699004117 Rhomboid family; Region: Rhomboid; pfam01694 633699004118 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 633699004119 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 633699004120 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 633699004121 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 633699004122 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 633699004123 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 633699004124 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 633699004125 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 633699004126 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 633699004127 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 633699004128 YceG-like family; Region: YceG; pfam02618 633699004129 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 633699004130 dimerization interface [polypeptide binding]; other site 633699004131 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 633699004132 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 633699004133 putative tRNA-binding site [nucleotide binding]; other site 633699004134 B3/4 domain; Region: B3_4; pfam03483 633699004135 tRNA synthetase B5 domain; Region: B5; smart00874 633699004136 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 633699004137 dimer interface [polypeptide binding]; other site 633699004138 motif 1; other site 633699004139 motif 3; other site 633699004140 motif 2; other site 633699004141 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 633699004142 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 633699004143 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 633699004144 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 633699004145 dimer interface [polypeptide binding]; other site 633699004146 motif 1; other site 633699004147 active site 633699004148 motif 2; other site 633699004149 motif 3; other site 633699004150 Predicted transcriptional regulators [Transcription]; Region: COG1733 633699004151 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 633699004152 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 633699004153 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 633699004154 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 633699004155 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 633699004156 OxaA-like protein precursor; Provisional; Region: PRK02463 633699004157 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 633699004158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 633699004159 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 633699004160 dimerization interface [polypeptide binding]; other site 633699004161 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633699004162 dimer interface [polypeptide binding]; other site 633699004163 phosphorylation site [posttranslational modification] 633699004164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633699004165 ATP binding site [chemical binding]; other site 633699004166 Mg2+ binding site [ion binding]; other site 633699004167 G-X-G motif; other site 633699004168 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633699004169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633699004170 active site 633699004171 phosphorylation site [posttranslational modification] 633699004172 intermolecular recognition site; other site 633699004173 dimerization interface [polypeptide binding]; other site 633699004174 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633699004175 DNA binding site [nucleotide binding] 633699004176 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 633699004177 hypothetical protein; Provisional; Region: PRK13670 633699004178 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 633699004179 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 633699004180 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633699004181 Zn2+ binding site [ion binding]; other site 633699004182 Mg2+ binding site [ion binding]; other site 633699004183 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 633699004184 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 633699004185 active site 633699004186 (T/H)XGH motif; other site 633699004187 GTPase YqeH; Provisional; Region: PRK13796 633699004188 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 633699004189 GTP/Mg2+ binding site [chemical binding]; other site 633699004190 G4 box; other site 633699004191 G5 box; other site 633699004192 G1 box; other site 633699004193 Switch I region; other site 633699004194 G2 box; other site 633699004195 G3 box; other site 633699004196 Switch II region; other site 633699004197 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 633699004198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699004199 active site 633699004200 motif I; other site 633699004201 motif II; other site 633699004202 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 633699004203 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 633699004204 23S rRNA binding site [nucleotide binding]; other site 633699004205 L21 binding site [polypeptide binding]; other site 633699004206 L13 binding site [polypeptide binding]; other site 633699004207 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 633699004208 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 633699004209 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 633699004210 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 633699004211 CAAX protease self-immunity; Region: Abi; pfam02517 633699004212 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 633699004213 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 633699004214 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 633699004215 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 633699004216 active site 633699004217 dimer interface [polypeptide binding]; other site 633699004218 motif 1; other site 633699004219 motif 2; other site 633699004220 motif 3; other site 633699004221 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 633699004222 anticodon binding site; other site 633699004223 primosomal protein DnaI; Reviewed; Region: PRK08939 633699004224 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 633699004225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699004226 Walker A motif; other site 633699004227 ATP binding site [chemical binding]; other site 633699004228 Walker B motif; other site 633699004229 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 633699004230 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 633699004231 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 633699004232 ATP cone domain; Region: ATP-cone; pfam03477 633699004233 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 633699004234 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 633699004235 CoA-binding site [chemical binding]; other site 633699004236 ATP-binding [chemical binding]; other site 633699004237 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 633699004238 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 633699004239 DNA binding site [nucleotide binding] 633699004240 catalytic residue [active] 633699004241 H2TH interface [polypeptide binding]; other site 633699004242 putative catalytic residues [active] 633699004243 turnover-facilitating residue; other site 633699004244 intercalation triad [nucleotide binding]; other site 633699004245 8OG recognition residue [nucleotide binding]; other site 633699004246 putative reading head residues; other site 633699004247 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 633699004248 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 633699004249 DNA polymerase I; Provisional; Region: PRK05755 633699004250 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 633699004251 active site 633699004252 metal binding site 1 [ion binding]; metal-binding site 633699004253 putative 5' ssDNA interaction site; other site 633699004254 metal binding site 3; metal-binding site 633699004255 metal binding site 2 [ion binding]; metal-binding site 633699004256 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 633699004257 putative DNA binding site [nucleotide binding]; other site 633699004258 putative metal binding site [ion binding]; other site 633699004259 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 633699004260 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 633699004261 active site 633699004262 DNA binding site [nucleotide binding] 633699004263 catalytic site [active] 633699004264 Class I aldolases; Region: Aldolase_Class_I; cl17187 633699004265 Class I aldolases; Region: Aldolase_Class_I; cl17187 633699004266 Class I aldolases; Region: Aldolase_Class_I; cl17187 633699004267 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633699004268 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633699004269 DNA-binding site [nucleotide binding]; DNA binding site 633699004270 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 633699004271 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 633699004272 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 633699004273 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 633699004274 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 633699004275 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 633699004276 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 633699004277 putative tRNA-binding site [nucleotide binding]; other site 633699004278 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 633699004279 catalytic residues [active] 633699004280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699004281 S-adenosylmethionine binding site [chemical binding]; other site 633699004282 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 633699004283 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 633699004284 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 633699004285 Walker A/P-loop; other site 633699004286 ATP binding site [chemical binding]; other site 633699004287 Q-loop/lid; other site 633699004288 ABC transporter signature motif; other site 633699004289 Walker B; other site 633699004290 D-loop; other site 633699004291 H-loop/switch region; other site 633699004292 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 633699004293 HIT family signature motif; other site 633699004294 catalytic residue [active] 633699004295 YtxH-like protein; Region: YtxH; cl02079 633699004296 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 633699004297 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 633699004298 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 633699004299 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 633699004300 generic binding surface II; other site 633699004301 generic binding surface I; other site 633699004302 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633699004303 Zn2+ binding site [ion binding]; other site 633699004304 Mg2+ binding site [ion binding]; other site 633699004305 P-loop containing region of AAA domain; Region: AAA_29; cl17516 633699004306 AAA domain; Region: AAA_23; pfam13476 633699004307 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 633699004308 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 633699004309 active site 633699004310 metal binding site [ion binding]; metal-binding site 633699004311 DNA binding site [nucleotide binding] 633699004312 hypothetical protein; Provisional; Region: PRK13676 633699004313 Transglycosylase; Region: Transgly; pfam00912 633699004314 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 633699004315 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 633699004316 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 633699004317 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 633699004318 active site 633699004319 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 633699004320 active site 633699004321 ATP binding site [chemical binding]; other site 633699004322 Phosphotransferase enzyme family; Region: APH; pfam01636 633699004323 antibiotic binding site [chemical binding]; other site 633699004324 Beta-lactamase; Region: Beta-lactamase; pfam00144 633699004325 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 633699004326 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 633699004327 ligand binding site [chemical binding]; other site 633699004328 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 633699004329 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 633699004330 ligand binding site [chemical binding]; other site 633699004331 flexible hinge region; other site 633699004332 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 633699004333 non-specific DNA interactions [nucleotide binding]; other site 633699004334 DNA binding site [nucleotide binding] 633699004335 sequence specific DNA binding site [nucleotide binding]; other site 633699004336 putative cAMP binding site [chemical binding]; other site 633699004337 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 633699004338 metal-binding site [ion binding] 633699004339 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 633699004340 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699004341 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 633699004342 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 633699004343 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 633699004344 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 633699004345 MucBP domain; Region: MucBP; pfam06458 633699004346 MucBP domain; Region: MucBP; pfam06458 633699004347 MucBP domain; Region: MucBP; pfam06458 633699004348 MucBP domain; Region: MucBP; pfam06458 633699004349 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 633699004350 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 633699004351 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 633699004352 Helix-turn-helix domain; Region: HTH_38; pfam13936 633699004353 Integrase core domain; Region: rve; pfam00665 633699004354 Recombinase; Region: Recombinase; pfam07508 633699004355 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 633699004356 Isochorismatase family; Region: Isochorismatase; pfam00857 633699004357 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 633699004358 catalytic triad [active] 633699004359 conserved cis-peptide bond; other site 633699004360 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 633699004361 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 633699004362 active site 633699004363 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 633699004364 nudix motif; other site 633699004365 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 633699004366 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 633699004367 TRAM domain; Region: TRAM; pfam01938 633699004368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699004369 S-adenosylmethionine binding site [chemical binding]; other site 633699004370 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 633699004371 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 633699004372 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633699004373 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 633699004374 Walker A/P-loop; other site 633699004375 ATP binding site [chemical binding]; other site 633699004376 Q-loop/lid; other site 633699004377 ABC transporter signature motif; other site 633699004378 Walker B; other site 633699004379 D-loop; other site 633699004380 H-loop/switch region; other site 633699004381 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 633699004382 Uncharacterized conserved protein [Function unknown]; Region: COG1912 633699004383 hypothetical protein; Provisional; Region: PRK13661 633699004384 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 633699004385 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633699004386 Walker A/P-loop; other site 633699004387 ATP binding site [chemical binding]; other site 633699004388 Q-loop/lid; other site 633699004389 ABC transporter signature motif; other site 633699004390 Walker B; other site 633699004391 D-loop; other site 633699004392 H-loop/switch region; other site 633699004393 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 633699004394 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 633699004395 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633699004396 Walker A/P-loop; other site 633699004397 ATP binding site [chemical binding]; other site 633699004398 Q-loop/lid; other site 633699004399 ABC transporter signature motif; other site 633699004400 Walker B; other site 633699004401 D-loop; other site 633699004402 H-loop/switch region; other site 633699004403 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 633699004404 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 633699004405 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 633699004406 glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728 633699004407 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699004408 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633699004409 active site 633699004410 motif I; other site 633699004411 motif II; other site 633699004412 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699004413 putative lipid kinase; Reviewed; Region: PRK13337 633699004414 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 633699004415 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 633699004416 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 633699004417 GatB domain; Region: GatB_Yqey; smart00845 633699004418 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 633699004419 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 633699004420 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 633699004421 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 633699004422 putative dimer interface [polypeptide binding]; other site 633699004423 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 633699004424 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 633699004425 putative dimer interface [polypeptide binding]; other site 633699004426 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 633699004427 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 633699004428 nucleotide binding pocket [chemical binding]; other site 633699004429 K-X-D-G motif; other site 633699004430 catalytic site [active] 633699004431 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 633699004432 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 633699004433 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 633699004434 Dimer interface [polypeptide binding]; other site 633699004435 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 633699004436 Part of AAA domain; Region: AAA_19; pfam13245 633699004437 Family description; Region: UvrD_C_2; pfam13538 633699004438 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 633699004439 Predicted membrane protein [Function unknown]; Region: COG4684 633699004440 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 633699004441 hypothetical protein; Provisional; Region: PRK04351 633699004442 SprT homologues; Region: SprT; cl01182 633699004443 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 633699004444 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 633699004445 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 633699004446 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 633699004447 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 633699004448 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 633699004449 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 633699004450 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 633699004451 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699004452 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 633699004453 Soluble P-type ATPase [General function prediction only]; Region: COG4087 633699004454 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 633699004455 stage V sporulation protein K; Region: spore_V_K; TIGR02881 633699004456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699004457 Walker A motif; other site 633699004458 ATP binding site [chemical binding]; other site 633699004459 Walker B motif; other site 633699004460 arginine finger; other site 633699004461 NAD synthetase; Reviewed; Region: nadE; PRK00768 633699004462 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 633699004463 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 633699004464 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 633699004465 active site 633699004466 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 633699004467 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 633699004468 active site 633699004469 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 633699004470 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 633699004471 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 633699004472 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 633699004473 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 633699004474 active site 633699004475 nucleotide binding site [chemical binding]; other site 633699004476 HIGH motif; other site 633699004477 KMSKS motif; other site 633699004478 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633699004479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633699004480 DNA-binding site [nucleotide binding]; DNA binding site 633699004481 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 633699004482 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 633699004483 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 633699004484 active site residue [active] 633699004485 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 633699004486 tetramer (dimer of dimers) interface [polypeptide binding]; other site 633699004487 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 633699004488 NAD binding site [chemical binding]; other site 633699004489 dimer interface [polypeptide binding]; other site 633699004490 substrate binding site [chemical binding]; other site 633699004491 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 633699004492 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 633699004493 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 633699004494 putative active site [active] 633699004495 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 633699004496 tetramer (dimer of dimers) interface [polypeptide binding]; other site 633699004497 active site 633699004498 dimer interface [polypeptide binding]; other site 633699004499 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 633699004500 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 633699004501 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 633699004502 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 633699004503 Predicted membrane protein [Function unknown]; Region: COG4905 633699004504 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 633699004505 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 633699004506 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633699004507 Coenzyme A binding pocket [chemical binding]; other site 633699004508 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 633699004509 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 633699004510 active site 633699004511 catalytic tetrad [active] 633699004512 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 633699004513 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 633699004514 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 633699004515 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 633699004516 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 633699004517 NAD binding site [chemical binding]; other site 633699004518 homodimer interface [polypeptide binding]; other site 633699004519 active site 633699004520 substrate binding site [chemical binding]; other site 633699004521 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 633699004522 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699004523 ATP binding site [chemical binding]; other site 633699004524 putative Mg++ binding site [ion binding]; other site 633699004525 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699004526 nucleotide binding region [chemical binding]; other site 633699004527 ATP-binding site [chemical binding]; other site 633699004528 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 633699004529 AAA ATPase domain; Region: AAA_16; pfam13191 633699004530 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 633699004531 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 633699004532 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 633699004533 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 633699004534 putative catalytic cysteine [active] 633699004535 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 633699004536 putative active site [active] 633699004537 metal binding site [ion binding]; metal-binding site 633699004538 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 633699004539 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 633699004540 Sulfatase; Region: Sulfatase; pfam00884 633699004541 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 633699004542 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 633699004543 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 633699004544 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 633699004545 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 633699004546 putative ADP-binding pocket [chemical binding]; other site 633699004547 seryl-tRNA synthetase; Provisional; Region: PRK05431 633699004548 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 633699004549 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 633699004550 dimer interface [polypeptide binding]; other site 633699004551 active site 633699004552 motif 1; other site 633699004553 motif 2; other site 633699004554 motif 3; other site 633699004555 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 633699004556 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 633699004557 Uncharacterized conserved protein [Function unknown]; Region: COG0398 633699004558 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 633699004559 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 633699004560 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 633699004561 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633699004562 salt bridge; other site 633699004563 non-specific DNA binding site [nucleotide binding]; other site 633699004564 sequence-specific DNA binding site [nucleotide binding]; other site 633699004565 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 633699004566 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 633699004567 NAD(P) binding site [chemical binding]; other site 633699004568 catalytic residues [active] 633699004569 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 633699004570 Double zinc ribbon; Region: DZR; pfam12773 633699004571 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 633699004572 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699004573 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633699004574 active site 633699004575 motif I; other site 633699004576 motif II; other site 633699004577 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 633699004578 MMPL family; Region: MMPL; pfam03176 633699004579 Predicted membrane protein [Function unknown]; Region: COG1511 633699004580 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 633699004581 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 633699004582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633699004583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 633699004584 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 633699004585 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 633699004586 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 633699004587 nucleotide binding site [chemical binding]; other site 633699004588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633699004589 Coenzyme A binding pocket [chemical binding]; other site 633699004590 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 633699004591 Transcriptional regulators [Transcription]; Region: MarR; COG1846 633699004592 MarR family; Region: MarR; pfam01047 633699004593 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 633699004594 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 633699004595 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 633699004596 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 633699004597 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 633699004598 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 633699004599 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 633699004600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699004601 dimer interface [polypeptide binding]; other site 633699004602 conserved gate region; other site 633699004603 putative PBP binding loops; other site 633699004604 ABC-ATPase subunit interface; other site 633699004605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699004606 dimer interface [polypeptide binding]; other site 633699004607 conserved gate region; other site 633699004608 putative PBP binding loops; other site 633699004609 ABC-ATPase subunit interface; other site 633699004610 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 633699004611 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 633699004612 Walker A/P-loop; other site 633699004613 ATP binding site [chemical binding]; other site 633699004614 Q-loop/lid; other site 633699004615 ABC transporter signature motif; other site 633699004616 Walker B; other site 633699004617 D-loop; other site 633699004618 H-loop/switch region; other site 633699004619 TOBE domain; Region: TOBE_2; pfam08402 633699004620 Peptidase family C69; Region: Peptidase_C69; pfam03577 633699004621 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 633699004622 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 633699004623 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 633699004624 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 633699004625 active site 633699004626 catalytic tetrad [active] 633699004627 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 633699004628 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 633699004629 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 633699004630 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 633699004631 active site 633699004632 catalytic site [active] 633699004633 substrate binding site [chemical binding]; other site 633699004634 BRCA1 C Terminus (BRCT) domain; Region: BRCT; pfam00533 633699004635 Dimer interface [polypeptide binding]; other site 633699004636 BRCT sequence motif; other site 633699004637 Predicted membrane protein [Function unknown]; Region: COG2323 633699004638 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 633699004639 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 633699004640 peptidase T; Region: peptidase-T; TIGR01882 633699004641 metal binding site [ion binding]; metal-binding site 633699004642 dimer interface [polypeptide binding]; other site 633699004643 PAS domain; Region: PAS_10; pfam13596 633699004644 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 633699004645 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 633699004646 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 633699004647 PAS domain; Region: PAS_10; pfam13596 633699004648 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 633699004649 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 633699004650 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 633699004651 substrate binding site [chemical binding]; other site 633699004652 THF binding site; other site 633699004653 zinc-binding site [ion binding]; other site 633699004654 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 633699004655 S-ribosylhomocysteinase; Provisional; Region: PRK02260 633699004656 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 633699004657 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 633699004658 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 633699004659 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 633699004660 active pocket/dimerization site; other site 633699004661 active site 633699004662 phosphorylation site [posttranslational modification] 633699004663 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 633699004664 active site 633699004665 phosphorylation site [posttranslational modification] 633699004666 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 633699004667 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 633699004668 peptide binding site [polypeptide binding]; other site 633699004669 EamA-like transporter family; Region: EamA; pfam00892 633699004670 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 633699004671 EamA-like transporter family; Region: EamA; pfam00892 633699004672 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 633699004673 beta-galactosidase; Region: BGL; TIGR03356 633699004674 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 633699004675 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 633699004676 HPr interaction site; other site 633699004677 glycerol kinase (GK) interaction site [polypeptide binding]; other site 633699004678 active site 633699004679 phosphorylation site [posttranslational modification] 633699004680 CAT RNA binding domain; Region: CAT_RBD; smart01061 633699004681 PRD domain; Region: PRD; pfam00874 633699004682 elongation factor P; Validated; Region: PRK00529 633699004683 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 633699004684 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 633699004685 RNA binding site [nucleotide binding]; other site 633699004686 Elongation factor P, C-terminal; Region: Elong-fact-P_C; pfam09285 633699004687 RNA binding site [nucleotide binding]; other site 633699004688 pantothenate kinase; Provisional; Region: PRK05439 633699004689 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 633699004690 ATP-binding site [chemical binding]; other site 633699004691 CoA-binding site [chemical binding]; other site 633699004692 Mg2+-binding site [ion binding]; other site 633699004693 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 633699004694 active site 633699004695 catalytic triad [active] 633699004696 oxyanion hole [active] 633699004697 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 633699004698 putative active site [active] 633699004699 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 633699004700 Part of AAA domain; Region: AAA_19; pfam13245 633699004701 Family description; Region: UvrD_C_2; pfam13538 633699004702 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 633699004703 active site 633699004704 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 633699004705 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 633699004706 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699004707 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 633699004708 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699004709 motif II; other site 633699004710 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 633699004711 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 633699004712 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 633699004713 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 633699004714 putative active site [active] 633699004715 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 633699004716 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 633699004717 putative active site cavity [active] 633699004718 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 633699004719 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl17885 633699004720 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 633699004721 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 633699004722 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 633699004723 active site turn [active] 633699004724 phosphorylation site [posttranslational modification] 633699004725 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 633699004726 glycerol kinase (GK) interaction site [polypeptide binding]; other site 633699004727 HPr interaction site; other site 633699004728 active site 633699004729 phosphorylation site [posttranslational modification] 633699004730 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699004731 catalytic core [active] 633699004732 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633699004733 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 633699004734 Walker A/P-loop; other site 633699004735 ATP binding site [chemical binding]; other site 633699004736 Q-loop/lid; other site 633699004737 ABC transporter signature motif; other site 633699004738 Walker B; other site 633699004739 D-loop; other site 633699004740 H-loop/switch region; other site 633699004741 Amino acid permease; Region: AA_permease_2; pfam13520 633699004742 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 633699004743 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 633699004744 HflX GTPase family; Region: HflX; cd01878 633699004745 G1 box; other site 633699004746 GTP/Mg2+ binding site [chemical binding]; other site 633699004747 Switch I region; other site 633699004748 G2 box; other site 633699004749 G3 box; other site 633699004750 Switch II region; other site 633699004751 G4 box; other site 633699004752 G5 box; other site 633699004753 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 633699004754 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 633699004755 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 633699004756 NlpC/P60 family; Region: NLPC_P60; pfam00877 633699004757 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 633699004758 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 633699004759 catalytic site [active] 633699004760 G-X2-G-X-G-K; other site 633699004761 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 633699004762 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 633699004763 dimer interface [polypeptide binding]; other site 633699004764 putative radical transfer pathway; other site 633699004765 diiron center [ion binding]; other site 633699004766 tyrosyl radical; other site 633699004767 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 633699004768 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 633699004769 Uncharacterized conserved protein [Function unknown]; Region: COG2966 633699004770 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 633699004771 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 633699004772 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633699004773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699004774 Walker A/P-loop; other site 633699004775 ATP binding site [chemical binding]; other site 633699004776 Q-loop/lid; other site 633699004777 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633699004778 ABC transporter signature motif; other site 633699004779 Walker B; other site 633699004780 D-loop; other site 633699004781 ABC transporter; Region: ABC_tran_2; pfam12848 633699004782 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633699004783 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 633699004784 oligoendopeptidase F; Region: pepF; TIGR00181 633699004785 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 633699004786 active site 633699004787 Zn binding site [ion binding]; other site 633699004788 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 633699004789 L-lactate permease; Region: Lactate_perm; cl00701 633699004790 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 633699004791 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 633699004792 ABC-ATPase subunit interface; other site 633699004793 dimer interface [polypeptide binding]; other site 633699004794 putative PBP binding regions; other site 633699004795 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 633699004796 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 633699004797 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 633699004798 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 633699004799 intersubunit interface [polypeptide binding]; other site 633699004800 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 633699004801 dimerization interface [polypeptide binding]; other site 633699004802 putative DNA binding site [nucleotide binding]; other site 633699004803 putative Zn2+ binding site [ion binding]; other site 633699004804 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 633699004805 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699004806 active site 633699004807 motif I; other site 633699004808 motif II; other site 633699004809 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699004810 MucBP domain; Region: MucBP; pfam06458 633699004811 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 633699004812 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 633699004813 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 633699004814 active site 633699004815 phosphorylation site [posttranslational modification] 633699004816 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 633699004817 active site 633699004818 P-loop; other site 633699004819 phosphorylation site [posttranslational modification] 633699004820 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 633699004821 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 633699004822 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 633699004823 putative substrate binding site [chemical binding]; other site 633699004824 putative ATP binding site [chemical binding]; other site 633699004825 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 633699004826 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 633699004827 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 633699004828 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 633699004829 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 633699004830 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 633699004831 trimer interface [polypeptide binding]; other site 633699004832 active site 633699004833 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 633699004834 catalytic site [active] 633699004835 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 633699004836 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 633699004837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699004838 Walker A/P-loop; other site 633699004839 ATP binding site [chemical binding]; other site 633699004840 Q-loop/lid; other site 633699004841 ABC transporter signature motif; other site 633699004842 Walker B; other site 633699004843 D-loop; other site 633699004844 H-loop/switch region; other site 633699004845 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 633699004846 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 633699004847 aspartate racemase; Region: asp_race; TIGR00035 633699004848 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 633699004849 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 633699004850 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 633699004851 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 633699004852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 633699004853 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633699004854 dimer interface [polypeptide binding]; other site 633699004855 phosphorylation site [posttranslational modification] 633699004856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633699004857 ATP binding site [chemical binding]; other site 633699004858 Mg2+ binding site [ion binding]; other site 633699004859 G-X-G motif; other site 633699004860 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633699004861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633699004862 active site 633699004863 phosphorylation site [posttranslational modification] 633699004864 intermolecular recognition site; other site 633699004865 dimerization interface [polypeptide binding]; other site 633699004866 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633699004867 DNA binding site [nucleotide binding] 633699004868 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633699004869 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633699004870 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 633699004871 Walker A/P-loop; other site 633699004872 ATP binding site [chemical binding]; other site 633699004873 Q-loop/lid; other site 633699004874 ABC transporter signature motif; other site 633699004875 Walker B; other site 633699004876 D-loop; other site 633699004877 H-loop/switch region; other site 633699004878 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633699004879 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633699004880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699004881 Walker A/P-loop; other site 633699004882 ATP binding site [chemical binding]; other site 633699004883 Q-loop/lid; other site 633699004884 ABC transporter signature motif; other site 633699004885 Walker B; other site 633699004886 D-loop; other site 633699004887 H-loop/switch region; other site 633699004888 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 633699004889 GTP-binding protein YchF; Reviewed; Region: PRK09601 633699004890 YchF GTPase; Region: YchF; cd01900 633699004891 G1 box; other site 633699004892 GTP/Mg2+ binding site [chemical binding]; other site 633699004893 Switch I region; other site 633699004894 G2 box; other site 633699004895 Switch II region; other site 633699004896 G3 box; other site 633699004897 G4 box; other site 633699004898 G5 box; other site 633699004899 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 633699004900 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 633699004901 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 633699004902 ParB-like nuclease domain; Region: ParB; smart00470 633699004903 KorB domain; Region: KorB; pfam08535 633699004904 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 633699004905 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 633699004906 P-loop; other site 633699004907 Magnesium ion binding site [ion binding]; other site 633699004908 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 633699004909 Magnesium ion binding site [ion binding]; other site 633699004910 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 633699004911 ParB-like nuclease domain; Region: ParB; smart00470 633699004912 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 633699004913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699004914 S-adenosylmethionine binding site [chemical binding]; other site 633699004915 Colicin V production protein; Region: Colicin_V; pfam02674 633699004916 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 633699004917 ApbE family; Region: ApbE; pfam02424 633699004918 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 633699004919 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 633699004920 Uncharacterized conserved protein [Function unknown]; Region: COG3589 633699004921 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 633699004922 Predicted flavoprotein [General function prediction only]; Region: COG0431 633699004923 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 633699004924 Predicted flavoprotein [General function prediction only]; Region: COG0431 633699004925 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 633699004926 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633699004927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 633699004928 WHG domain; Region: WHG; pfam13305 633699004929 Peptidase family C69; Region: Peptidase_C69; pfam03577 633699004930 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 633699004931 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 633699004932 CAT RNA binding domain; Region: CAT_RBD; cl03904 633699004933 CAT RNA binding domain; Region: CAT_RBD; smart01061 633699004934 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633699004935 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 633699004936 Walker A/P-loop; other site 633699004937 ATP binding site [chemical binding]; other site 633699004938 Q-loop/lid; other site 633699004939 ABC transporter signature motif; other site 633699004940 Walker B; other site 633699004941 D-loop; other site 633699004942 H-loop/switch region; other site 633699004943 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 633699004944 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 633699004945 FtsX-like permease family; Region: FtsX; pfam02687 633699004946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633699004947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 633699004948 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699004949 catalytic core [active] 633699004950 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699004951 catalytic core [active] 633699004952 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 633699004953 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 633699004954 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 633699004955 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 633699004956 catalytic site [active] 633699004957 hypothetical protein; Validated; Region: PRK02101 633699004958 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 633699004959 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 633699004960 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 633699004961 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 633699004962 putative active site [active] 633699004963 catalytic site [active] 633699004964 putative metal binding site [ion binding]; other site 633699004965 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 633699004966 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 633699004967 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 633699004968 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 633699004969 putative active site [active] 633699004970 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 633699004971 nucleotide binding site/active site [active] 633699004972 HIT family signature motif; other site 633699004973 catalytic residue [active] 633699004974 Class I aldolases; Region: Aldolase_Class_I; cl17187 633699004975 drug efflux system protein MdtG; Provisional; Region: PRK09874 633699004976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699004977 putative substrate translocation pore; other site 633699004978 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 633699004979 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 633699004980 catalytic triad [active] 633699004981 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633699004982 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633699004983 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 633699004984 Walker A/P-loop; other site 633699004985 ATP binding site [chemical binding]; other site 633699004986 Q-loop/lid; other site 633699004987 ABC transporter signature motif; other site 633699004988 Walker B; other site 633699004989 D-loop; other site 633699004990 H-loop/switch region; other site 633699004991 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 633699004992 putative ADP-ribose binding site [chemical binding]; other site 633699004993 putative active site [active] 633699004994 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 633699004995 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 633699004996 active site turn [active] 633699004997 phosphorylation site [posttranslational modification] 633699004998 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 633699004999 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 633699005000 HPr interaction site; other site 633699005001 glycerol kinase (GK) interaction site [polypeptide binding]; other site 633699005002 active site 633699005003 phosphorylation site [posttranslational modification] 633699005004 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 633699005005 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 633699005006 substrate binding [chemical binding]; other site 633699005007 active site 633699005008 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 633699005009 Transcriptional regulators [Transcription]; Region: PurR; COG1609 633699005010 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 633699005011 DNA binding site [nucleotide binding] 633699005012 domain linker motif; other site 633699005013 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 633699005014 dimerization interface [polypeptide binding]; other site 633699005015 ligand binding site [chemical binding]; other site 633699005016 sodium binding site [ion binding]; other site 633699005017 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 633699005018 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 633699005019 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 633699005020 substrate binding site [chemical binding]; other site 633699005021 dimer interface [polypeptide binding]; other site 633699005022 ATP binding site [chemical binding]; other site 633699005023 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 633699005024 catalytic triad [active] 633699005025 amino acid transporter; Region: 2A0306; TIGR00909 633699005026 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 633699005027 EamA-like transporter family; Region: EamA; pfam00892 633699005028 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 633699005029 EamA-like transporter family; Region: EamA; pfam00892 633699005030 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 633699005031 dimer interface [polypeptide binding]; other site 633699005032 active site 633699005033 Amino acid permease; Region: AA_permease; pfam00324 633699005034 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 633699005035 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 633699005036 catalytic triad [active] 633699005037 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 633699005038 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 633699005039 Domain of unknown function (DUF956); Region: DUF956; pfam06115 633699005040 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 633699005041 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 633699005042 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 633699005043 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 633699005044 active pocket/dimerization site; other site 633699005045 active site 633699005046 phosphorylation site [posttranslational modification] 633699005047 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 633699005048 active site 633699005049 phosphorylation site [posttranslational modification] 633699005050 amino acid transporter; Region: 2A0306; TIGR00909 633699005051 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 633699005052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699005053 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 633699005054 Walker A motif; other site 633699005055 ATP binding site [chemical binding]; other site 633699005056 Walker B motif; other site 633699005057 arginine finger; other site 633699005058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699005059 Walker A motif; other site 633699005060 ATP binding site [chemical binding]; other site 633699005061 Walker B motif; other site 633699005062 arginine finger; other site 633699005063 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 633699005064 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 633699005065 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 633699005066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699005067 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633699005068 putative substrate translocation pore; other site 633699005069 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 633699005070 Beta-lactamase; Region: Beta-lactamase; pfam00144 633699005071 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 633699005072 DltD N-terminal region; Region: DltD_N; pfam04915 633699005073 DltD central region; Region: DltD_M; pfam04918 633699005074 DltD C-terminal region; Region: DltD_C; pfam04914 633699005075 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 633699005076 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 633699005077 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 633699005078 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 633699005079 acyl-activating enzyme (AAE) consensus motif; other site 633699005080 AMP binding site [chemical binding]; other site 633699005081 FOG: CBS domain [General function prediction only]; Region: COG0517 633699005082 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 633699005083 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 633699005084 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699005085 Soluble P-type ATPase [General function prediction only]; Region: COG4087 633699005086 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 633699005087 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 633699005088 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633699005089 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633699005090 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 633699005091 Walker A/P-loop; other site 633699005092 ATP binding site [chemical binding]; other site 633699005093 Q-loop/lid; other site 633699005094 ABC transporter signature motif; other site 633699005095 Walker B; other site 633699005096 D-loop; other site 633699005097 H-loop/switch region; other site 633699005098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633699005099 non-specific DNA binding site [nucleotide binding]; other site 633699005100 salt bridge; other site 633699005101 sequence-specific DNA binding site [nucleotide binding]; other site 633699005102 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 633699005103 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 633699005104 putative substrate binding pocket [chemical binding]; other site 633699005105 AC domain interface; other site 633699005106 catalytic triad [active] 633699005107 AB domain interface; other site 633699005108 interchain disulfide; other site 633699005109 Predicted membrane protein [Function unknown]; Region: COG3817 633699005110 Protein of unknown function (DUF979); Region: DUF979; pfam06166 633699005111 Protein of unknown function (DUF969); Region: DUF969; pfam06149 633699005112 Protein of unknown function (DUF805); Region: DUF805; pfam05656 633699005113 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 633699005114 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 633699005115 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 633699005116 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 633699005117 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 633699005118 CAAX protease self-immunity; Region: Abi; pfam02517 633699005119 Uncharacterized conserved protein [Function unknown]; Region: COG1434 633699005120 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 633699005121 putative active site [active] 633699005122 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633699005123 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 633699005124 Walker A/P-loop; other site 633699005125 ATP binding site [chemical binding]; other site 633699005126 Q-loop/lid; other site 633699005127 ABC transporter signature motif; other site 633699005128 Walker B; other site 633699005129 D-loop; other site 633699005130 H-loop/switch region; other site 633699005131 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 633699005132 FtsX-like permease family; Region: FtsX; pfam02687 633699005133 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 633699005134 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 633699005135 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 633699005136 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 633699005137 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633699005138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699005139 Walker A/P-loop; other site 633699005140 ATP binding site [chemical binding]; other site 633699005141 Q-loop/lid; other site 633699005142 ABC transporter signature motif; other site 633699005143 Walker B; other site 633699005144 D-loop; other site 633699005145 H-loop/switch region; other site 633699005146 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 633699005147 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633699005148 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 633699005149 Walker A/P-loop; other site 633699005150 ATP binding site [chemical binding]; other site 633699005151 Q-loop/lid; other site 633699005152 ABC transporter signature motif; other site 633699005153 Walker B; other site 633699005154 D-loop; other site 633699005155 H-loop/switch region; other site 633699005156 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 633699005157 UbiA prenyltransferase family; Region: UbiA; pfam01040 633699005158 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 633699005159 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633699005160 substrate binding pocket [chemical binding]; other site 633699005161 membrane-bound complex binding site; other site 633699005162 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 633699005163 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 633699005164 ligand binding site [chemical binding]; other site 633699005165 Beta-lactamase; Region: Beta-lactamase; pfam00144 633699005166 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 633699005167 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 633699005168 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 633699005169 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 633699005170 Uncharacterized conserved protein [Function unknown]; Region: COG3589 633699005171 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 633699005172 Putative esterase; Region: Esterase; pfam00756 633699005173 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 633699005174 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 633699005175 active site 633699005176 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 633699005177 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 633699005178 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 633699005179 putative active site [active] 633699005180 hypothetical protein; Provisional; Region: PRK10621 633699005181 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 633699005182 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 633699005183 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 633699005184 active site 633699005185 catalytic tetrad [active] 633699005186 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 633699005187 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 633699005188 active site 633699005189 trimer interface [polypeptide binding]; other site 633699005190 allosteric site; other site 633699005191 active site lid [active] 633699005192 hexamer (dimer of trimers) interface [polypeptide binding]; other site 633699005193 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 633699005194 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 633699005195 Substrate-binding site [chemical binding]; other site 633699005196 Substrate specificity [chemical binding]; other site 633699005197 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 633699005198 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 633699005199 Substrate-binding site [chemical binding]; other site 633699005200 Substrate specificity [chemical binding]; other site 633699005201 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 633699005202 teramer interface [polypeptide binding]; other site 633699005203 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 633699005204 active site 633699005205 FMN binding site [chemical binding]; other site 633699005206 catalytic residues [active] 633699005207 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 633699005208 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 633699005209 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 633699005210 DNA binding residues [nucleotide binding] 633699005211 dimer interface [polypeptide binding]; other site 633699005212 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 633699005213 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 633699005214 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 633699005215 metal binding site [ion binding]; metal-binding site 633699005216 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 633699005217 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 633699005218 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 633699005219 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633699005220 non-specific DNA binding site [nucleotide binding]; other site 633699005221 salt bridge; other site 633699005222 sequence-specific DNA binding site [nucleotide binding]; other site 633699005223 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 633699005224 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 633699005225 active site 633699005226 catalytic residues [active] 633699005227 metal binding site [ion binding]; metal-binding site 633699005228 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 633699005229 Penicillinase repressor; Region: Pencillinase_R; pfam03965 633699005230 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 633699005231 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 633699005232 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 633699005233 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699005234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699005235 motif II; other site 633699005236 Amino acid permease; Region: AA_permease_2; pfam13520 633699005237 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 633699005238 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 633699005239 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 633699005240 catalytic residue [active] 633699005241 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 633699005242 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 633699005243 Aluminium resistance protein; Region: Alum_res; pfam06838 633699005244 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 633699005245 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633699005246 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 633699005247 Coenzyme A binding pocket [chemical binding]; other site 633699005248 cation transport protein; Region: 2A0119; TIGR00898 633699005249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699005250 MutS domain III; Region: MutS_III; pfam05192 633699005251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633699005252 Walker A/P-loop; other site 633699005253 ATP binding site [chemical binding]; other site 633699005254 Q-loop/lid; other site 633699005255 ABC transporter signature motif; other site 633699005256 Walker B; other site 633699005257 D-loop; other site 633699005258 H-loop/switch region; other site 633699005259 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 633699005260 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 633699005261 Cl- selectivity filter; other site 633699005262 Cl- binding residues [ion binding]; other site 633699005263 pore gating glutamate residue; other site 633699005264 dimer interface [polypeptide binding]; other site 633699005265 H+/Cl- coupling transport residue; other site 633699005266 TrkA-C domain; Region: TrkA_C; pfam02080 633699005267 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 633699005268 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 633699005269 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 633699005270 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 633699005271 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 633699005272 PYR/PP interface [polypeptide binding]; other site 633699005273 dimer interface [polypeptide binding]; other site 633699005274 tetramer interface [polypeptide binding]; other site 633699005275 TPP binding site [chemical binding]; other site 633699005276 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 633699005277 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 633699005278 TPP-binding site [chemical binding]; other site 633699005279 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 633699005280 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 633699005281 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 633699005282 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 633699005283 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 633699005284 trmE is a tRNA modification GTPase; Region: trmE; cd04164 633699005285 G1 box; other site 633699005286 GTP/Mg2+ binding site [chemical binding]; other site 633699005287 Switch I region; other site 633699005288 G2 box; other site 633699005289 Switch II region; other site 633699005290 G3 box; other site 633699005291 G4 box; other site 633699005292 G5 box; other site 633699005293 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 633699005294 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 633699005295 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 633699005296 ribonuclease P; Reviewed; Region: rnpA; PRK00499 633699005297 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 633699005298 chain length determinant protein EpsF; Region: EpsF; TIGR03017 633699005299 Initiator Replication protein; Region: Rep_3; pfam01051 633699005300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633699005301 non-specific DNA binding site [nucleotide binding]; other site 633699005302 salt bridge; other site 633699005303 sequence-specific DNA binding site [nucleotide binding]; other site 633699005304 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 633699005305 active site 633699005306 DNA binding site [nucleotide binding] 633699005307 Int/Topo IB signature motif; other site 633699005308 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 633699005309 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 633699005310 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 633699005311 Domain of unknown function (DUF955); Region: DUF955; cl01076 633699005312 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 633699005313 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 633699005316 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 633699005317 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 633699005318 dimer interface [polypeptide binding]; other site 633699005319 ssDNA binding site [nucleotide binding]; other site 633699005320 tetramer (dimer of dimers) interface [polypeptide binding]; other site 633699005321 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 633699005322 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 633699005323 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633699005324 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 633699005325 Walker A/P-loop; other site 633699005326 ATP binding site [chemical binding]; other site 633699005327 Q-loop/lid; other site 633699005328 ABC transporter signature motif; other site 633699005329 Walker B; other site 633699005330 D-loop; other site 633699005331 H-loop/switch region; other site 633699005332 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633699005333 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 633699005334 Walker A/P-loop; other site 633699005335 ATP binding site [chemical binding]; other site 633699005336 Q-loop/lid; other site 633699005337 ABC transporter signature motif; other site 633699005338 Walker B; other site 633699005339 D-loop; other site 633699005340 H-loop/switch region; other site 633699005341 YcaO-like family; Region: YcaO; pfam02624 633699005342 ThiF family; Region: ThiF; pfam00899 633699005343 ATP binding site [chemical binding]; other site