-- dump date 20140619_123824 -- class Genbank::CDS -- table cds_note -- id note NP_964015.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. NP_964018.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA NP_964021.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 NP_964023.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit NP_964024.1 contains Mg+ and Co2+ transporter domain NP_964025.1 contains DHH phosphoesterase domain NP_964026.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk NP_964031.1 contains amino acid permease domain NP_964033.1 contains acyltransferase domain NP_964035.1 contains transcriptional regulator helix-turn-helix domain NP_964036.1 contains ThiF family domain NP_964039.1 contains probable haloacid dehalogenase-like hydrolase domain NP_964040.1 contains DUF194 domain NP_964042.1 contains transcriptional regulator helix-turn-helix domain NP_964043.1 contains elongation factor Tu GTP binding domain NP_964044.1 contains voltage gated chloride channel domain NP_964046.1 contains transcriptional regulator helix-turn-helix domain NP_964049.1 contains CorA-like Mg2+ transporter domain NP_964053.1 contains helicase conserved C-terminal domain NP_964057.1 contains DUF20 region NP_964058.1 contains pyridine nucleotide-disulphide oxidoreductase domain NP_964063.1 contains gram positive anchor domain NP_964065.1 contains amino acid permease domain NP_964066.1 contains transcriptional regulator helix-turn-helix domain, lysR family NP_964067.1 contains FAD binding domain NP_964069.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone NP_964075.1 contains acyltransferase domain NP_964076.1 contains glycosyl transferase family 8 domain NP_964077.1 contains glycosyl transferase family 8 domain NP_964078.1 contains glycosyl transferase family 8 domain NP_964085.1 contains metallo-beta-lactamase superfamily region NP_964087.1 contains DUF163 domain; SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA NP_964091.1 contains transcriptional regulator helix-turn-helix domain, araC family NP_964092.1 putative metalloprotease NP_964097.1 contains glycosyl transferase family 2 region NP_964098.1 contains glycosyl transferase family 8 region NP_964100.1 contains HNH site-specific endonuclease domain NP_964106.1 contains membrane protein TerC domain NP_964109.1 contains SIR2 domain; Modulates the activities of several enzymes which are inactive in their acetylated form NP_964112.1 contains zinc protease domain NP_964114.1 contains RNase H domain NP_964116.1 contains glycosyl transferase family 2 region NP_964117.1 contains alpha/beta hydrolase fold domain NP_964121.1 contains bacterial regulatory protein tetR domain NP_964124.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli NP_964125.1 contains chromosome segregation ATPase domain NP_964126.1 contains sodium/hydrogen exchanger family domain NP_964130.1 contains acetyl esterase domain NP_964131.1 contains glycosyl hydrolases family 31 domain NP_964132.1 contains bacterial regulatory gntR domain NP_964134.1 contains N-acetylglucosamine-6-phosphate deacetylase domain NP_964142.1 contains bacterial regulatory gntR domain NP_964143.1 contains protein tyrosine/serine phosphatase domain NP_964144.1 universal stress protein family region NP_964145.1 similar to phosphonates solute-binding protein NP_964153.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates NP_964155.1 contains DUF59 domain NP_964158.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources NP_964160.1 contains transcriptional regulator helix-turn-helix domain NP_964165.1 contains phosphoenolpyruvate carboxykinase domain NP_964166.1 contains K+ potassium transporter domain NP_964167.1 contains K+ potassium transporter domain NP_964169.1 contains TPR-repeat domain NP_964171.1 contains mannosyl-glycoprotein endo-beta-N-acetylglucosamidase domain NP_964172.1 contains glycosyl hydrolases family 25 domain NP_964174.1 contains pfkB family carbohydrate kinase domain NP_964175.1 contains potassium channel domain NP_964176.1 contains oxidoreductase family, NAD-binding Rossmann domain NP_964180.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate NP_964186.1 contains integral membrane protein DUF6 domain NP_964187.1 similar to uncharacterized enzymes related to aldose 1-epimerase NP_964188.1 similar to transcriptional regulator lytR NP_964189.1 contains DUF205 domain NP_964193.1 contains HD superfamily hydrolase domain NP_964196.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus NP_964197.1 contains Hsp20/alpha crystallin domain NP_964200.1 required for cellobiose uptake and metabolism NP_964201.1 contains bacterial regulatory gntR domain NP_964205.1 contains bacterial regulatory gntR domain NP_964211.1 contains bacterial regulatory ROK domain NP_964213.1 contains DUF159 domain NP_964214.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_964217.1 contains E1-E2 ATPase domain NP_964218.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content NP_964219.1 contains TatD-related DNase domain NP_964220.1 contains toprim domain NP_964221.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin NP_964223.1 contains phosphoribosyl transferase domain NP_964224.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis NP_964226.1 contains bacterial regulatory lacI domain NP_964227.1 contains alpha amylase catalytic domain NP_964232.1 contains bacterial extracellular solute-binding domain NP_964236.1 contains HD domain NP_964238.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling NP_964239.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer NP_964240.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active NP_964242.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine NP_964244.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway NP_964246.1 contains sodium bile acid symporter domain NP_964252.1 contains phage integrase domain NP_964254.1 contains bacterial regulatory protein tetR domain NP_964256.1 contains transcriptional regulator helix-turn-helix domain NP_964257.1 contains NAD(P)H dehydrogenase (quinone) domain NP_964258.1 contains bacterial regulatory protein tetR domain NP_964265.1 contains acetyltransferase (GNAT) domain NP_964266.1 possible metallothionein NP_964267.1 contains zinc-binding dehydrogenase domain NP_964268.1 contains UPF0074 domain NP_964280.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate NP_964284.1 contains amino acid permease domain NP_964285.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome NP_964288.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids NP_964293.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation NP_964295.1 contains S4 domain NP_964297.1 contains S1 RNA binding domain NP_964298.1 contains single-strand binding domain NP_964302.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers NP_964303.1 contains UPF0034 domain NP_964304.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 NP_964352.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme NP_964353.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter NP_964354.1 contains type III leader peptidase domain NP_964355.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance NP_964356.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit NP_964357.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene NP_964358.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex NP_964359.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin NP_964360.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA NP_964361.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel NP_964362.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation NP_964363.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA NP_964364.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center NP_964365.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation NP_964366.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e NP_964367.1 one of the stabilizing components for the large ribosomal subunit NP_964368.1 primary binding protein; helps mediate assembly; involved in translation fidelity NP_964369.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase NP_964370.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel NP_964371.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 NP_964372.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif NP_964373.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit NP_964374.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance NP_964375.1 binds 5S rRNA along with protein L5 and L25 NP_964376.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance NP_964377.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 NP_964378.1 late assembly protein NP_964379.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase NP_964380.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP NP_964381.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 NP_964382.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif NP_964383.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA NP_964384.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 NP_964385.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme NP_964386.1 is a component of the macrolide binding site in the peptidyl transferase center NP_964387.1 with CbiNQ forms the ABC transporter for cobalt import; Lactobacillus has two adjacent copies of this gene NP_964388.1 with CbiNQ forms the ABC transporter for cobalt import; Lactobacillus has two adjacent copies of this gene NP_964390.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability NP_964391.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit NP_964392.1 forms a direct contact with the tRNA during translation NP_964395.1 contains phosphoglycerate mutase domain NP_964398.1 contains ThiJ/PfpI domain NP_964399.1 contains phosphoglycerate mutase domain NP_964400.1 contains bacterial regulatory arsR domain NP_964401.1 contains cation efflux domain NP_964406.1 contains gram positive anchor domain NP_964407.1 contains amino acid permease domain NP_964408.1 contains eubacterial secY domain NP_964412.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, especially gram positive pathogens, have paralogs that have been found to be nonessential but do function in secretion of a subset of exported proteins NP_964413.1 contains glycosyl transferases group 1 domain NP_964416.1 contains glycosyl transferase family 2 domain NP_964419.1 similar to transcriptional regulator lytR NP_964421.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents NP_964422.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation NP_964423.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA NP_964424.1 contains uncharacterized BCR domain NP_964425.1 contains SpoU rRNA methylase family domain NP_964429.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate NP_964430.1 contains permease domain NP_964431.1 contains polyprenyl synthetase domain NP_964432.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif NP_964433.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force NP_964435.1 binds directly to 23S ribosomal RNA NP_964436.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA NP_964440.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit NP_964441.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors NP_964442.1 contains ion transport domain NP_964444.1 contains SAM-dependent methyltransferase domain NP_964447.1 contains cytidine and deoxycytidylate deaminase domain NP_964449.1 contains DUF149 domain NP_964450.1 involved in a recombinational process of DNA repair, independent of the recBC complex NP_964452.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) NP_964454.1 contains ATPase involved in DNA replication domain NP_964455.1 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA NP_964456.1 contains tetrapyrrole (Corrin/Porphyrin) methylase domain NP_964459.1 contains glycoprotease domain NP_964460.1 contains acetyltransferase (GNAT) domain NP_964461.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity NP_964465.1 contains voltage gated chloride channel domain NP_964466.1 contains IMP dehydrogenase/GMP reductase domains NP_964467.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis NP_964468.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide NP_964469.1 contains predicted EndoIII-related endonuclease domain NP_964470.1 contains MutT-like domain NP_964475.1 contains predicted acyl-CoA transferases/carnitine dehydratase domain NP_964476.1 contains transcriptional regulator helix-turn-helix domain NP_964478.1 contains bacterial extracellular solute-binding domain NP_964480.1 modulates transcription in response to the NADH/NAD(+) redox state NP_964481.1 contains predicted Rossmann fold nucleotide-binding domain NP_964486.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring NP_964487.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth NP_964488.1 contains transcriptional regulator helix-turn-helix domain NP_964491.1 This protein performs the mismatch recognition step during the DNA repair process NP_964492.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex NP_964493.1 plays an essential role in ATP-dependent branch migration of the Holliday junction NP_964494.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration NP_964495.1 contains DUF219 domain NP_964496.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate NP_964498.1 contains DHH domain NP_964500.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_964502.1 contains predicted endonuclease involved in recombination domain; similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function NP_964509.1 contains Ham1 domain; hydrolyzes non-standard nucleotides such as xanthine and inosine NP_964510.1 contains gram positive anchor domain NP_964512.1 contains mechanosensitive ion channel domain NP_964514.1 contains methyl-accepting chemotaxis domain NP_964518.1 contains penicillin binding protein transpeptidase and transglycosylase domains NP_964519.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases NP_964520.1 contains glycerophosphoryl diester phosphodiesterase domain NP_964522.1 contains 5'-nucleotidase catalytic domain NP_964524.1 contains haloacid dehalogenase-like hydrolase domain NP_964527.1 contains pyridine nucleotide-disulphide oxidoreductase domain NP_964528.1 contains S1 RNA binding domain NP_964529.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase NP_964531.1 contains PAP2 superfamily domain NP_964532.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase NP_964536.1 contains UPF0031 domain NP_964538.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase NP_964542.1 contains glutamine amidotransferase class-I domain NP_964543.1 contains predicted nucleoside-diphosphate-sugar epimerase domain NP_964546.1 contains GAF domain NP_964550.1 contains permease domain NP_964551.1 contains CAAX amino terminal protease domain NP_964555.1 contains acetyltransferase (GNAT) domain NP_964556.1 ATPase involved in DNA replication initiation domain NP_964557.1 contains haloacid dehalogenase-like hydrolase domain NP_964559.1 contains haloacid dehalogenase-like hydrolase domain NP_964560.1 contains transcriptional regulator helix-turn-helix domain NP_964563.1 contains adenylylsulfate kinase and related kinase domain NP_964564.1 contains phosphoglycerate mutase domain NP_964566.1 contains PAP2 superfamily domain NP_964569.1 contains amino acid permease domain NP_964572.1 contains amino acid permease domain NP_964573.1 contains amino acid permease domain NP_964576.1 contains bacterial regulatory marR domain NP_964579.1 contains cellulase M domain NP_964581.1 contains uncharacterized ACR domain NP_964582.1 contains phosphatidylserine decarboxylase domain NP_964584.1 contains phosphatidylserine decarboxylase domain NP_964586.1 contains bacterial regulatory protein ROK domain NP_964587.1 contains bacterial regulatory protein ROK domain NP_964589.1 contains glycosyl hydrolases family 31 domain; catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides NP_964590.1 contains beta-galactosidase domain NP_964596.1 contains bacterial regulatory lacI domain NP_964601.1 contains bacterial regulatory protein marR domain NP_964615.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor NP_964632.1 contains CAAX amino terminal protease domain NP_964638.1 contains E1-E2 ATPase domain NP_964639.1 contains E1-E2 ATPase domain NP_964640.1 contains UPF0028 domain NP_964643.1 contains acetyltransferase (GNAT) domain NP_964647.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation NP_964648.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation NP_964650.1 contains short chain fatty acid transporter domain NP_964651.1 ferritin-like protein NP_964653.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway NP_964654.1 contains inosine-uridine nucleoside N-ribohydrolase domain NP_964655.1 contains bacterial regulatory gntR domain NP_964656.1 contains inosine-uridine preferring nucleoside domain NP_964657.1 contains bacterial regulatory deoR domain NP_964659.1 contains nitroreductase domain NP_964661.1 contains CBS domain NP_964662.1 contains CBS domain NP_964666.1 contains DEAD/DEAH box helicase domain NP_964673.1 contains arsenate reductase domain NP_964674.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence NP_964678.1 contains guanosine polyphosphate pyrophosphohydrolase/synthetase domain NP_964679.1 catalyzes the phosphorylation of NAD to NADP NP_964680.1 contains RNA pseudouridylate synthase domain NP_964681.1 in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever NP_964682.1 contains ATPase involved in DNA replication initiation domain NP_964685.1 contains DUF20 domain NP_964686.1 contains SpoU rRNA methylase domain NP_964689.1 contains predicted Zn-dependent peptidase domain NP_964690.1 contains peptidase family M16 domain NP_964691.1 contains short chain dehydrogenase domain NP_964694.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs NP_964695.1 contains HD domain; protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP NP_964696.1 contains glycosyl transferase domain NP_964697.1 contains UPF0029 domain NP_964700.1 contains sigma 54 modulation domain NP_964701.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, there are paralogous proteins that have been found to be nonessential but do function in secretion of a subset of exported proteins NP_964704.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system NP_964705.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein NP_964706.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate NP_964714.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism NP_964715.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism NP_964718.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion NP_964721.1 contains uncharacterized BCR domain NP_964722.1 contains UPF0052 region NP_964723.1 contains DUF199 region NP_964724.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates NP_964728.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway NP_964729.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate NP_964730.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis NP_964733.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation NP_964734.1 contains acetyltransferase (GNAT) domain NP_964735.1 contains transcriptional regulator helix-turn-helix domain, AraR family NP_964737.1 contains haloacid dehalogenase-like hydrolase domain NP_964738.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine NP_964739.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta NP_964740.1 contains uncharacterized P-loop hydrolase UPF0079 domain NP_964741.1 contains exonuclease domain NP_964742.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis NP_964747.1 contains DUF147 domain NP_964749.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate NP_964750.1 contains predicted hydrolases of the HAD superfamily domain NP_964751.1 contains CrcB-like domain NP_964752.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling NP_964755.1 contains alpha/beta hydrolase fold domain NP_964756.1 contains lipoprotein domain NP_964759.1 contains DUF28 domain NP_964760.1 contains bacterial type II secretion system protein domain NP_964761.1 contains general secretion pathway protein F domain NP_964766.1 contains type I restriction-modification system methyltransferase domain NP_964770.1 contains aminotransferase class I and II domain NP_964775.1 contains alkaline phosphatase superfamily domain NP_964776.1 contains alkaline phosphatase superfamily domain NP_964777.1 contains alkaline phosphatase superfamily domain NP_964779.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family NP_964780.1 contains permease domain NP_964782.1 contains penicillin binding protein domain NP_964783.1 contains Mur ligase family, catalytic domain NP_964784.1 catalyzes the formation of thymidine 5'-phosphate from thymidine NP_964785.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 NP_964786.1 contains SAM-dependent methyltransferase domain NP_964787.1 contains yrdC domain NP_964788.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate NP_964789.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 NP_964790.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 NP_964791.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. NP_964792.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex NP_964793.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit NP_964794.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit NP_964795.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit NP_964796.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane NP_964799.1 contains DUF37 domain NP_964801.1 contains cellcycle protein domain NP_964802.1 contains universal stress protein domain NP_964804.1 ATPase family associated contains various cellular activities domain NP_964806.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination NP_964807.1 contains chromosome segregation ATPase domain; acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation NP_964809.1 Required for the synthesis of the thiazole moiety NP_964811.1 contains glycerophosphoryl diester phosphodiesterase domain NP_964813.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain NP_964814.1 similar to folylpolyglutamate synthase NP_964815.1 contains haloacid dehalogenase-like hydrolase domain NP_964817.1 functions in MreBCD complex in some organisms NP_964818.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall NP_964821.1 MraZ; UPF0040; crystal structure shows similarity to AbrB NP_964825.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan NP_964826.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation NP_964827.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis NP_964830.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function NP_964831.1 contains uncharacterized BCR domain NP_964832.1 contains YGGT family domain NP_964833.1 contains S4 domain NP_964834.1 possible cell-division initiation protein (divIVA) NP_964835.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme NP_964842.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs NP_964843.1 contains phosphoglycerate mutase family domain NP_964844.1 contains TPR-repeat domain NP_964845.1 contains ATP-dependent exoDNAse alpha chain domain NP_964846.1 contains diacylglycerol kinase catalytic domain NP_964847.1 contains UPF0036 domain NP_964849.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) NP_964852.1 contains cellcycle protein domain NP_964854.1 contains N6-adenine-specific methylase domain NP_964855.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA NP_964856.1 contains PDZ domain NP_964857.1 contains transcriptional regulator helix-turn-helix domain NP_964859.1 contains metallo-beta-lactamase domain NP_964861.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase NP_964862.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence NP_964863.1 contains metallo-beta-lactamase superfamily and uncharacterized protein family UPF0036 domains NP_964865.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu NP_964866.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer NP_964867.1 binds and unfolds substrates as part of the ClpXP protease NP_964868.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential NP_964869.1 contains low molecular weight phosphotyrosine protein phosphatase domain NP_964871.1 contains 2-hydroxychromene-2-carboxylate isomerase family domain NP_964874.1 contains protein-disulfide isomerase domain NP_964877.1 similar to transcriptional regulator lytR NP_964883.1 contains glycosyl transferases group 1 domain NP_964884.1 contains glycosyl transferases group 1 domain NP_964885.1 contains glycosyl transferases group 1 domain NP_964886.1 contains glycosyl transferases group 2 domain NP_964890.1 contains polysaccharide biosynthesis protein domain NP_964903.1 contains bacterial regulatory proteins, merR family domain NP_964909.1 contains transcriptional regulator helix-turn-helix domain NP_964910.1 contains SMC domain N terminal domain NP_964911.1 contains UvrD/REP helicase domain NP_964915.1 contains NUDIX domain NP_964920.1 contains amino acid permease domain NP_964921.1 contains predicted nucleoside-diphosphate-sugar epimerase domain NP_964922.1 contains phage integrase, N-terminal SAM-like domain NP_964924.1 contains inosine-uridine preferring nucleoside hydrolase domain NP_964925.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision NP_964926.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication NP_964927.1 contains DUF33 family domain NP_964929.1 contains short chain dehydrogenase domain NP_964931.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not NP_964932.1 contains 5'-nucleotidase, catalytic and C-terminal domains NP_964935.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis NP_964940.1 contains uncharacterized ACR, COG1354 domain NP_964941.1 contains uncharacterized ACR domain NP_964943.1 contains LysM domain NP_964945.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP NP_964946.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins NP_964947.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains NP_964949.1 contains TPR Domain NP_964954.1 contains ion transport protein domain NP_964955.1 contains DUF161 family domain NP_964956.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity NP_964958.1 contains DUF194 family domain NP_964961.1 contains GTPase domain NP_964962.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids NP_964964.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity NP_964965.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine NP_964967.1 heat shock protein involved in degradation of misfolded proteins NP_964968.1 heat shock protein involved in degradation of misfolded proteins NP_964971.1 contains predicted membrane-bound metal-dependent hydrolase domain NP_964974.1 contains transcriptional regulator helix-turn-helix domain NP_964976.1 contains zinc-binding dehydrogenase domain NP_964980.1 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase NP_964984.1 contains gram positive anchor domain NP_964986.1 contains haloacid dehalogenase-like domain NP_964987.1 contains MutT-like domain NP_964991.1 contains zinc-binding dehydrogenase domain NP_964995.1 contains UPF0051 domain NP_964998.1 contains UPF0051 domain NP_964999.1 contains DUF59 domain NP_965001.1 contains SAM-dependent methyltransferase domain NP_965008.1 contains DUF174 domain NP_965012.1 contains bacterial regulatory proteins, marR family domain NP_965016.1 contains ATPase family associated with various cellular activities domain NP_965019.1 contains UPF0005 domain NP_965025.1 contains DUF205 domain NP_965026.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling NP_965027.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling NP_965028.1 contains transcriptional regulator helix-turn-helix domain NP_965029.1 catalyzes the hydrolysis of pyrophosphate to phosphate NP_965031.1 contains cyclophilin type peptidyl-prolyl cis-trans isomerase domain NP_965033.1 contains phage integrase domain; site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS NP_965034.1 contains transcriptional regulator helix-turn-helix domain NP_965036.1 contains DUF194 domain NP_965037.1 contains bacterial regulatory marR domain NP_965039.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity NP_965040.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers NP_965042.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis NP_965043.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate NP_965045.1 contains DUF194 domain NP_965047.1 contains predicted phosphohydrolase domain NP_965048.1 contains UPF0020 domain NP_965051.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC NP_965054.1 similar to DNA replication protein DnaD NP_965055.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_965057.1 contains exonuclease domain NP_965058.1 contains UvrD/REP helicase domain NP_965063.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate NP_965067.1 contains aminoglycoside 3-N-acetyltransferase domain NP_965069.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source NP_965070.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate NP_965072.1 contains phosphorylase domain NP_965073.1 contains phosphorylase domain NP_965074.1 contains MutT-like domain NP_965076.1 contains phosphoribulokinase / uridine kinase domain NP_965079.1 contains predicted hydrolase or acyltransferase domain NP_965080.1 contains MutT-like domain NP_965081.1 contains acetyltransferase (GNAT) domain NP_965082.1 contains acetyltransferase (GNAT) domain NP_965083.1 contains alpha/beta hydrolase domain NP_965090.1 contains HIT family hydrolase domain NP_965091.1 contains acetyltransferase (GNAT) domain NP_965094.1 contains acetyltransferase domain NP_965099.1 contains nitroreductase domain NP_965101.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis NP_965105.1 contains SPFH domain / Band 7 domain NP_965109.1 contains NADH:flavin oxidoreductase / NADH oxidase domain NP_965111.1 contains nitroreductase domain NP_965115.1 contains bacterial regulatory lacI domain NP_965117.1 contains transcriptional antiterminator bglG domain NP_965120.1 contains bacterial regulatory lacI domain NP_965126.1 contains glycosyl transferase group 1 domain NP_965129.1 contains isochorismatase domain NP_965130.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity NP_965131.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity NP_965132.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers NP_965133.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis NP_965134.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis NP_965135.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity NP_965136.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits NP_965137.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase NP_965138.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate NP_965140.1 contains haloacid dehalogenase-like hydrolase domain NP_965141.1 contains DUF218 domain NP_965142.1 contains DUF74 domain NP_965143.1 contains NOL1/NOP2/sun domain NP_965152.1 contains transcriptional regulator helix-turn-helix domain NP_965157.1 contains bacterial regulatory gntR domain NP_965158.1 catalyzes the release of the N-terminal amino acid from a tripeptide NP_965159.1 contains DUF34 domain NP_965171.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium NP_965173.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA NP_965174.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA NP_965176.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome NP_965177.1 contains UPF0054 domain NP_965180.1 contains DUF186 domain; a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA NP_965182.1 contains DUF59 domain NP_965185.1 contains DUF161 domain NP_965189.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress NP_965191.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes NP_965192.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG NP_965193.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine NP_965196.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype NP_965200.1 contains cation-transporting ATPase domain NP_965203.1 Converts (S)-lactate and NAD(+) to pyruvate and NADH NP_965205.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle NP_965211.1 contains transcriptional regulator helix-turn-helix domain NP_965216.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis NP_965217.1 contains PAP2 superfamily domain NP_965268.1 contains transcriptional regulator helix-turn-helix domain NP_965273.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived NP_965276.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis NP_965277.1 contains recJ exonuclease domain NP_965279.1 binds to the ribosome on the universally-conserved alpha-sarcin loop NP_965280.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion NP_965281.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria NP_965282.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor NP_965283.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons NP_965287.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs NP_965288.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock NP_965289.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex NP_965290.1 contains ribosomal protein L7Ae/L30e/S12e/Gadd4 domain NP_965292.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination NP_965293.1 contains DUF150 domain; in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins NP_965295.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) NP_965298.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate NP_965299.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs NP_965300.1 Catalyzes the phosphorylation of UMP to UDP NP_965301.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu NP_965302.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit NP_965303.1 contains SAM-dependent methyltransferase domain NP_965304.1 contains acyltransferase domain NP_965305.1 contains cyclopropane-fatty-acyl-phospholipid domain NP_965310.1 Represses a number of genes involved in the response to DNA damage NP_965311.1 contains uracil-DNA glycosylase domain NP_965312.1 contains MutT-like domain NP_965314.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site NP_965315.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA NP_965316.1 Essential for efficient processing of 16S rRNA NP_965317.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity NP_965319.1 contains uncharacterized BCR domain NP_965323.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity NP_965330.1 carries the fatty acid chain in fatty acid biosynthesis NP_965331.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY NP_965332.1 catalyzes branch migration in Holliday junction intermediates NP_965333.1 contains DAK2 domain NP_965334.1 contains uncharacterized BCR domain NP_965335.1 required for 70S ribosome assembly NP_965336.1 contains predicted nucleotide-binding domain NP_965338.1 contains predicted GTPase domain NP_965339.1 contains protein kinase domain NP_965340.1 contains protein phosphatase 2C domain NP_965345.1 Essential for recycling GMP and indirectly, cGMP NP_965349.1 farnesyl-diphosphate synthase NP_965350.1 catalyzes the bidirectional exonucleolytic cleavage of DNA NP_965351.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides NP_965352.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate NP_965353.1 contains NusB domain NP_965354.1 contains uncharacterized BCR domain NP_965355.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA NP_965357.1 involved in the peptidyltransferase reaction during translation NP_965359.1 contains arsenate reductase ArsG and related proteins, glutaredoxin family domain NP_965360.1 contains DUF161 domain NP_965364.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown NP_965366.1 contains pyridoxal/pyridoxine/pyridoxamine kinase domain NP_965370.1 contains transcriptional regulator helix-turn-helix domain NP_965371.1 contains transcriptional regulator helix-turn-helix domain, AraC family NP_965373.1 contains bacterial regulatory ROK domain NP_965379.1 contains bacterial regulatory merR domain NP_965383.1 contains fic protein domain NP_965385.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source NP_965387.1 contains haloacid dehalogenase-like hydrolase domain NP_965389.1 catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue NP_965395.1 possible glycine betaine/carnitine/choline NP_965396.1 possible glycine betaine/carnitine/choline NP_965398.1 contains tRNA-processing ribonuclease BN domain NP_965400.1 contains flavodoxin domain NP_965404.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein NP_965405.1 contains CBS domain NP_965409.1 contains recX domain; binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities NP_965410.1 contains TRAM domain NP_965414.1 contains alpha/beta hydrolases domain NP_965416.1 contains predicted hydrolases of the HAD superfamily domain NP_965419.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity NP_965421.1 contains rhodanese-like domain NP_965423.1 contains rhomboid family domain NP_965424.1 contains 5-formyltetrahydrofolate cyclo-ligase domain NP_965425.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif NP_965429.1 contains DUF175 domain NP_965430.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily NP_965431.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily NP_965432.1 contains DUF24 domain NP_965433.1 contains SpoU rRNA methylase domain NP_965439.1 contains uncharacterized ACR domain NP_965440.1 contains DUF143 domain NP_965441.1 contains HD domain NP_965443.1 contains GTPase of unknown function domain; in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis NP_965444.1 contains HAD superfamily domain NP_965445.1 contains adenosine/AMP deaminase domain; catalyzes the formation of inosine from adenosine NP_965446.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit NP_965448.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits NP_965452.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) NP_965453.1 Primosomal protein that may act to load helicase DnaC during DNA replication NP_965454.1 similar to DnaB NP_965455.1 contains DUF193 domain NP_965456.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis NP_965457.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases NP_965464.1 contains periplasmic sugar-binding domain NP_965467.1 contains periplasmic sugar-binding domain NP_965469.1 contains bacterial regulatory gntR domain NP_965470.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis NP_965474.1 contains putative methyltransferase domain; tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine NP_965480.1 cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein NP_965482.1 contains ATPase involved in DNA repair domain NP_965483.1 contains DNA repair exonuclease domain NP_965486.1 contains RNA pseudouridylate synthase domain NP_965487.1 contains gram positive anchor domain and similarity to IgA proteases NP_965495.1 contains aminoglycoside phosphotransferase domain NP_965496.1 contains penicillin binding protein domain NP_965500.1 contains bacterial regulatory crp domain NP_965502.1 contains heavy-metal-associated domain NP_965505.1 contains TRAM domain NP_965509.1 contains DUF62 domain NP_965513.1 contains UPF0005 domain NP_965514.1 contains glycosyl transferase family 8 domain NP_965515.1 contains glycosyl transferase family 8 domain NP_965518.1 contains gram positive anchor domain NP_965519.1 contains predicted HAD hydrolase domain NP_965520.1 contains diacylglycerol kinase catalytic domain; similar to YegS from E. coli NP_965521.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_965522.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_965527.1 contains mannosyl-glycoprotein endo-beta-N-acetylglucosamidase domain NP_965532.1 contains polysaccharide biosynthesis transport domain NP_965533.1 contains putative glycosyl/glycerophosphate transferase domain involved in teichoic acid biosynthesis NP_965534.1 contains transcriptional regulator helix-turn-helix domain NP_965537.1 contains AAA+ class ATPase domain NP_965538.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers NP_965539.1 contains nicotinic acid phosphoribosyltransferase domain; catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate NP_965540.1 contains glycosyl transferase group 2 domain NP_965541.1 contains glycosyl transferase group 1 domain NP_965544.1 contains bacterial regulatory gntR domain NP_965546.1 contains rhodanese-related sulfurtransferase domain NP_965554.1 contains acetyltransferase (GNAT) domain NP_965555.1 contains phage integrase domain NP_965558.1 contains FtsK/SpoIIIE domain NP_965561.1 contains transcriptional regulator helix-turn-helix domain NP_965566.1 contains DEAD/DEAH box helicase domain NP_965573.1 contains amino acid permease domain NP_965574.1 contains alkaline phosphatase superfamily domain NP_965576.1 contains glycosyl transferases group 1 domain NP_965577.1 contains glycosyl transferases group 1 domain NP_965579.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_965580.1 contains acetyltransferase (GNAT) domain NP_965581.1 contains uncharacterized ACR domain NP_965582.1 contains acetyl esterase domain NP_965583.1 contains transcriptional regulator helix-turn-helix domain NP_965586.1 contains uncharacterized ACR domain NP_965587.1 contains haloacid dehalogenase-like hydrolase domain NP_965589.1 contains bacterial regulatory protein tetR domain NP_965591.1 contains bacterial regulatory protein ROK domain NP_965592.1 contains acetyltransferase (GNAT) domain NP_965594.1 contains bacterial regulatory protein marR domain NP_965596.1 contains bacterial extracellular solute-binding domain NP_965597.1 contains predicted metal-dependent hydrolase 3 domain NP_965605.1 contains permease domain NP_965606.1 contains exonuclease domain NP_965610.1 catalyzes the release of the N-terminal amino acid from a tripeptide NP_965612.1 contains permease domain NP_965614.1 contains gram positive anchor domain NP_965615.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock NP_965618.1 contains transcriptional regulator helix-turn-helix domain NP_965622.1 contains sodium/dicarboxylate symporter domain NP_965623.1 contains methionine synthase, vitamin-B12 independent domain NP_965624.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 NP_965630.1 drug/metabolite transporter superfamily NP_965632.1 contains transcriptional antiterminator bglG domain NP_965634.1 contains gram positive anchor domain NP_965635.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA NP_965636.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis NP_965637.1 contains lipase/acylhydrolase with GDSL-like motif domain NP_965639.1 contains superfamily I DNA and RNA helicase domain NP_965643.1 contains transcriptional regulator helix-turn-helix domain NP_965644.1 possible N-acetylmannosamine-6-phosphate epimerase; Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate NP_965646.1 ExoA NP_965652.1 contains amino acid permease domain NP_965656.1 contains GTPase domain NP_965657.1 contains uncharacterized ACR domain NP_965658.1 contains NLP/P60 family domain NP_965663.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF NP_965664.1 contains ribonucleotide reductase, small chain domain; B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE NP_965666.1 contains PemK-like protein domain NP_965669.1 contains permease domain NP_965673.1 similar to transcriptional regulator lytR NP_965676.1 possibly for Mn/Zn NP_965677.1 possibly for Mn/Zn NP_965678.1 possibly for Mn/Zn NP_965679.1 contains transcriptional regulator helix-turn-helix domain, arsR family NP_965680.1 contains predicted hydrolases of the HAD superfamily domain NP_965685.1 contains bacterial regulatory protein deoR domain NP_965690.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate NP_965696.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 NP_965701.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA NP_965703.1 contains thiamine biosynthesis lipoprotein domain apbE NP_965706.1 contains predicted flavoprotein domain NP_965707.1 contains predicted flavoprotein domain NP_965708.1 contains bacterial regulatory protein tetR domain NP_965713.1 contains transcriptional antiterminator bglG domain NP_965716.1 contains bacterial regulatory protein tetR domain NP_965717.1 contains phosphoglycerate mutase domain NP_965718.1 contains phosphoglycerate mutase domain NP_965719.1 contains alpha/beta hydrolase fold domain NP_965725.1 contains glycerophosphoryl diester phosphodiester domain NP_965727.1 contains transcriptional regulator helix-turn-helix domain, rpiR family NP_965729.1 contains 3-dehydroquinate dehydratase domain NP_965731.1 contains permease domain NP_965732.1 contains permease domain NP_965733.1 contains glutamine amidotransferase class-I domain NP_965735.1 contains appr-1'-p processing enzyme domain NP_965742.1 contains amino acid permease domain NP_965743.1 contains DUF6 domain NP_965744.1 catalyzes the formation of asparagine from aspartate and ammonia NP_965745.1 contains amino acid permease domain NP_965746.1 contains glutamine amidotransferase class-I domain NP_965747.1 contains amino acid permease domain NP_965748.1 contains amino acid permease domain NP_965759.1 contains penicillin binding protein domain NP_965761.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid NP_965763.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid NP_965770.1 contains CBS domain NP_965775.1 contains transcriptional regulator helix-turn-helix domain NP_965777.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline NP_965785.1 contains CAAX amino terminal protease domain NP_965793.1 contains 1,4-dihydroxy-2-naphthoate octaprenyltransferase domain NP_965794.1 contains putative phosphate/phosphonate-binding protein domain NP_965795.1 similar to CD4+ T cell-stimulating antigen precursor NP_965796.1 contains transcriptional regulator helix-turn-helix domain, rpiR family domain NP_965798.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway NP_965800.1 contains DUF81 domain NP_965801.1 contains aldo/keto reductase domain NP_965806.1 contains uracil-xanthine permease domain NP_965807.1 contains bacterial regulatory merR domain NP_965808.1 contains uracil-xanthine permease domain NP_965809.1 contains uracil-xanthine permease domain NP_965810.1 contains transcriptional regulator helix-turn-helix domain NP_965811.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) NP_965818.1 contains gram positive anchor domain NP_965820.1 cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein NP_965823.1 contains cystathionine beta-lyase/cystathionine gamma-synthase domain NP_965824.1 contains acetyltransferase (GNAT) domain NP_965828.1 contains DNA mutS mismatch repair domain NP_965829.1 similar to chloride channel protein EriC NP_965830.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate NP_965832.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs NP_965833.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE NP_965835.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates