-- dump date 20140619_123851 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1033837000001 Initiator Replication protein; Region: Rep_3; pfam01051 1033837000002 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1033837000003 Phosphotransferase enzyme family; Region: APH; pfam01636 1033837000004 active site 1033837000005 ATP binding site [chemical binding]; other site 1033837000006 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1033837000007 substrate binding site [chemical binding]; other site 1033837000008 FMN-binding domain; Region: FMN_bind; cl01081 1033837000009 hypothetical protein; Validated; Region: PRK07121 1033837000010 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1033837000011 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1033837000012 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1033837000013 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033837000014 DNA-binding site [nucleotide binding]; DNA binding site 1033837000015 FCD domain; Region: FCD; pfam07729 1033837000016 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 1033837000017 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1033837000018 putative NAD(P) binding site [chemical binding]; other site 1033837000019 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1033837000020 peptidase T; Region: peptidase-T; TIGR01882 1033837000021 metal binding site [ion binding]; metal-binding site 1033837000022 dimer interface [polypeptide binding]; other site 1033837000023 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1033837000024 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1033837000025 peptide binding site [polypeptide binding]; other site 1033837000026 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 1033837000027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1033837000028 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1033837000029 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1033837000030 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 1033837000031 RNA/DNA hybrid binding site [nucleotide binding]; other site 1033837000032 active site 1033837000033 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1033837000034 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1033837000035 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1033837000036 MULE transposase domain; Region: MULE; pfam10551 1033837000037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1033837000038 Fic family protein [Function unknown]; Region: COG3177 1033837000039 Fic/DOC family; Region: Fic; pfam02661 1033837000040 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1033837000041 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1033837000042 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1033837000043 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1033837000044 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1033837000045 PemK-like protein; Region: PemK; pfam02452 1033837000046 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1033837000047 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1033837000048 DNA-binding interface [nucleotide binding]; DNA binding site 1033837000049 Integrase core domain; Region: rve; pfam00665 1033837000050 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1033837000051 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1033837000052 MULE transposase domain; Region: MULE; pfam10551 1033837000053 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1033837000054 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1033837000055 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1033837000056 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1033837000057 DNA binding residues [nucleotide binding] 1033837000058 methyl coenzyme M reductase system, component A2; Region: met_CoM_red_A2; TIGR03269 1033837000059 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1033837000060 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1033837000061 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1033837000062 NlpC/P60 family; Region: NLPC_P60; pfam00877 1033837000063 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 1033837000064 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1033837000065 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1033837000066 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1033837000067 SecY translocase; Region: SecY; pfam00344 1033837000068 nucleotide binding region [chemical binding]; other site 1033837000069 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1033837000070 ATP-binding site [chemical binding]; other site 1033837000071 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1033837000072 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1033837000073 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1033837000074 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1033837000075 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 1033837000076 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 1033837000077 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 1033837000078 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 1033837000079 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 1033837000080 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 1033837000081 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 1033837000082 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033837000083 active site 1033837000084 DNA binding site [nucleotide binding] 1033837000085 Int/Topo IB signature motif; other site 1033837000086 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 1033837000087 DNA polymerase III subunit beta; Validated; Region: PRK05643 1033837000088 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1033837000089 putative DNA binding surface [nucleotide binding]; other site 1033837000090 dimer interface [polypeptide binding]; other site 1033837000091 beta-clamp/clamp loader binding surface; other site 1033837000092 beta-clamp/translesion DNA polymerase binding surface; other site 1033837000093 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033837000094 active site 1033837000095 DNA binding site [nucleotide binding] 1033837000096 Int/Topo IB signature motif; other site 1033837000097 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033837000098 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 1033837000099 catalytic triad [active] 1033837000100 putative active site [active] 1033837000101 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 1033837000102 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837000103 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837000104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033837000105 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1033837000106 non-specific DNA binding site [nucleotide binding]; other site 1033837000107 salt bridge; other site 1033837000108 sequence-specific DNA binding site [nucleotide binding]; other site 1033837000109 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1033837000110 Transglycosylase; Region: Transgly; pfam00912 1033837000111 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1033837000112 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1033837000113 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1033837000114 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1033837000115 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1033837000116 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033837000117 active site 1033837000118 DNA binding site [nucleotide binding] 1033837000119 Int/Topo IB signature motif; other site 1033837000120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1033837000121 Probable transposase; Region: OrfB_IS605; pfam01385 1033837000122 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1033837000123 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1033837000124 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1033837000125 DNA binding residues [nucleotide binding] 1033837000126 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1033837000127 catalytic residues [active] 1033837000128 catalytic nucleophile [active] 1033837000129 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1033837000130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1033837000131 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1033837000132 Probable transposase; Region: OrfB_IS605; pfam01385 1033837000133 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1033837000134 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1033837000135 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 1033837000136 AAA-like domain; Region: AAA_10; pfam12846 1033837000137 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837000138 Walker A/P-loop; other site 1033837000139 ATP binding site [chemical binding]; other site 1033837000140 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1033837000141 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1033837000142 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1033837000143 Fic/DOC family; Region: Fic; cl00960 1033837000144 Class I aldolases; Region: Aldolase_Class_I; cl17187 1033837000145 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1033837000146 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1033837000147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1033837000148 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1033837000149 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1033837000150 active site 1033837000151 catalytic site [active] 1033837000152 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1033837000153 nucleotide binding site [chemical binding]; other site 1033837000154 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1033837000155 Mg binding site [ion binding]; other site 1033837000156 nucleotide binding site [chemical binding]; other site 1033837000157 putative protofilament interface [polypeptide binding]; other site 1033837000158 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1033837000159 Walker B motif; other site 1033837000160 Neuralized; Region: Neuralized; cl02685 1033837000161 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1033837000162 Walker A motif; other site 1033837000163 ATP binding site [chemical binding]; other site 1033837000164 Walker B motif; other site 1033837000165 Initiator Replication protein; Region: Rep_3; pfam01051 1033837000166 Predicted secreted protein [Function unknown]; Region: COG4086 1033837000167 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1033837000168 NlpC/P60 family; Region: NLPC_P60; cl17555 1033837000169 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1033837000170 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1033837000171 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1033837000172 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1033837000173 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1033837000174 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1033837000175 Catalytic site [active] 1033837000176 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1033837000177 IHF dimer interface [polypeptide binding]; other site 1033837000178 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 1033837000179 IHF - DNA interface [nucleotide binding]; other site 1033837000180 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1033837000181 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1033837000182 Fic/DOC family; Region: Fic; cl00960 1033837000183 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1033837000184 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1033837000185 dimer interface [polypeptide binding]; other site 1033837000186 ssDNA binding site [nucleotide binding]; other site 1033837000187 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1033837000188 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1033837000189 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1033837000190 Probable transposase; Region: OrfB_IS605; pfam01385 1033837000191 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1033837000192 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1033837000193 IHF dimer interface [polypeptide binding]; other site 1033837000194 IHF - DNA interface [nucleotide binding]; other site 1033837000195 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1033837000196 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1033837000197 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1033837000198 putative translocon binding site; other site 1033837000199 protein-rRNA interface [nucleotide binding]; other site 1033837000200 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1033837000201 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1033837000202 G-X-X-G motif; other site 1033837000203 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1033837000204 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1033837000205 23S rRNA interface [nucleotide binding]; other site 1033837000206 5S rRNA interface [nucleotide binding]; other site 1033837000207 putative antibiotic binding site [chemical binding]; other site 1033837000208 L25 interface [polypeptide binding]; other site 1033837000209 L27 interface [polypeptide binding]; other site 1033837000210 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1033837000211 23S rRNA interface [nucleotide binding]; other site 1033837000212 putative translocon interaction site; other site 1033837000213 signal recognition particle (SRP54) interaction site; other site 1033837000214 L23 interface [polypeptide binding]; other site 1033837000215 trigger factor interaction site; other site 1033837000216 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1033837000217 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1033837000218 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1033837000219 RNA binding site [nucleotide binding]; other site 1033837000220 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1033837000221 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1033837000222 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1033837000223 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1033837000224 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1033837000225 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1033837000226 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1033837000227 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1033837000228 23S rRNA interface [nucleotide binding]; other site 1033837000229 L21e interface [polypeptide binding]; other site 1033837000230 5S rRNA interface [nucleotide binding]; other site 1033837000231 L27 interface [polypeptide binding]; other site 1033837000232 L5 interface [polypeptide binding]; other site 1033837000233 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 1033837000234 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1033837000235 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1033837000236 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1033837000237 23S rRNA binding site [nucleotide binding]; other site 1033837000238 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1033837000239 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1033837000240 SecY translocase; Region: SecY; pfam00344 1033837000241 adenylate kinase; Reviewed; Region: adk; PRK00279 1033837000242 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1033837000243 AMP-binding site [chemical binding]; other site 1033837000244 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1033837000245 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1033837000246 rRNA binding site [nucleotide binding]; other site 1033837000247 predicted 30S ribosome binding site; other site 1033837000248 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1033837000249 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1033837000250 30S ribosomal protein S11; Validated; Region: PRK05309 1033837000251 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1033837000252 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1033837000253 alphaNTD homodimer interface [polypeptide binding]; other site 1033837000254 alphaNTD - beta interaction site [polypeptide binding]; other site 1033837000255 alphaNTD - beta' interaction site [polypeptide binding]; other site 1033837000256 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1033837000257 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1033837000258 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13640 1033837000259 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1033837000260 Walker A/P-loop; other site 1033837000261 ATP binding site [chemical binding]; other site 1033837000262 Q-loop/lid; other site 1033837000263 ABC transporter signature motif; other site 1033837000264 Walker B; other site 1033837000265 D-loop; other site 1033837000266 H-loop/switch region; other site 1033837000267 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13641 1033837000268 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1033837000269 Walker A/P-loop; other site 1033837000270 ATP binding site [chemical binding]; other site 1033837000271 Q-loop/lid; other site 1033837000272 ABC transporter signature motif; other site 1033837000273 Walker B; other site 1033837000274 D-loop; other site 1033837000275 H-loop/switch region; other site 1033837000276 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1033837000277 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1033837000278 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1033837000279 dimerization interface 3.5A [polypeptide binding]; other site 1033837000280 active site 1033837000281 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1033837000282 23S rRNA interface [nucleotide binding]; other site 1033837000283 L3 interface [polypeptide binding]; other site 1033837000284 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1033837000285 LytTr DNA-binding domain; Region: LytTR; smart00850 1033837000286 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1033837000287 DJ-1 family protein; Region: not_thiJ; TIGR01383 1033837000288 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1033837000289 conserved cys residue [active] 1033837000290 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1033837000291 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1033837000292 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1033837000293 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1033837000294 catalytic core [active] 1033837000295 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1033837000296 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1033837000297 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1033837000298 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1033837000299 catalytic core [active] 1033837000300 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1033837000301 AAA domain; Region: AAA_33; pfam13671 1033837000302 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1033837000303 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1033837000304 Probable transposase; Region: OrfB_IS605; pfam01385 1033837000305 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1033837000306 magnesium-transporting ATPase; Provisional; Region: PRK15122 1033837000307 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1033837000308 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1033837000309 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1033837000310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837000311 motif II; other site 1033837000312 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1033837000313 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1033837000314 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1033837000315 trimer interface [polypeptide binding]; other site 1033837000316 active site 1033837000317 G bulge; other site 1033837000318 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1033837000319 trimer interface [polypeptide binding]; other site 1033837000320 active site 1033837000321 DNA repair protein RadA; Provisional; Region: PRK11823 1033837000322 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1033837000323 Walker A motif/ATP binding site; other site 1033837000324 ATP binding site [chemical binding]; other site 1033837000325 Walker B motif; other site 1033837000326 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1033837000327 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1033837000328 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1033837000329 active site 1033837000330 HIGH motif; other site 1033837000331 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1033837000332 active site 1033837000333 KMSKS motif; other site 1033837000334 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1033837000335 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1033837000336 active site 1033837000337 HIGH motif; other site 1033837000338 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1033837000339 KMSKS motif; other site 1033837000340 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1033837000341 tRNA binding surface [nucleotide binding]; other site 1033837000342 anticodon binding site; other site 1033837000343 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1033837000344 active site 1033837000345 metal binding site [ion binding]; metal-binding site 1033837000346 dimerization interface [polypeptide binding]; other site 1033837000347 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1033837000348 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1033837000349 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1033837000350 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1033837000351 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1033837000352 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1033837000353 N- and C-terminal domain interface [polypeptide binding]; other site 1033837000354 active site 1033837000355 catalytic site [active] 1033837000356 metal binding site [ion binding]; metal-binding site 1033837000357 carbohydrate binding site [chemical binding]; other site 1033837000358 ATP binding site [chemical binding]; other site 1033837000359 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1033837000360 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033837000361 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 1033837000362 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1033837000363 TPP-binding site; other site 1033837000364 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1033837000365 PYR/PP interface [polypeptide binding]; other site 1033837000366 dimer interface [polypeptide binding]; other site 1033837000367 TPP binding site [chemical binding]; other site 1033837000368 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1033837000369 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1033837000370 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1033837000371 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1033837000372 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1033837000373 putative homodimer interface [polypeptide binding]; other site 1033837000374 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1033837000375 heterodimer interface [polypeptide binding]; other site 1033837000376 homodimer interface [polypeptide binding]; other site 1033837000377 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1033837000378 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1033837000379 23S rRNA interface [nucleotide binding]; other site 1033837000380 L7/L12 interface [polypeptide binding]; other site 1033837000381 putative thiostrepton binding site; other site 1033837000382 L25 interface [polypeptide binding]; other site 1033837000383 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1033837000384 mRNA/rRNA interface [nucleotide binding]; other site 1033837000385 PBP superfamily domain; Region: PBP_like_2; cl17296 1033837000386 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1033837000387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837000388 dimer interface [polypeptide binding]; other site 1033837000389 conserved gate region; other site 1033837000390 putative PBP binding loops; other site 1033837000391 ABC-ATPase subunit interface; other site 1033837000392 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1033837000393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837000394 dimer interface [polypeptide binding]; other site 1033837000395 conserved gate region; other site 1033837000396 putative PBP binding loops; other site 1033837000397 ABC-ATPase subunit interface; other site 1033837000398 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 1033837000399 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1033837000400 Walker A/P-loop; other site 1033837000401 ATP binding site [chemical binding]; other site 1033837000402 Q-loop/lid; other site 1033837000403 ABC transporter signature motif; other site 1033837000404 Walker B; other site 1033837000405 D-loop; other site 1033837000406 H-loop/switch region; other site 1033837000407 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14251 1033837000408 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1033837000409 Walker A/P-loop; other site 1033837000410 ATP binding site [chemical binding]; other site 1033837000411 Q-loop/lid; other site 1033837000412 ABC transporter signature motif; other site 1033837000413 Walker B; other site 1033837000414 D-loop; other site 1033837000415 H-loop/switch region; other site 1033837000416 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1033837000417 PhoU domain; Region: PhoU; pfam01895 1033837000418 PhoU domain; Region: PhoU; pfam01895 1033837000419 Membrane transport protein; Region: Mem_trans; cl09117 1033837000420 Membrane transport protein; Region: Mem_trans; cl09117 1033837000421 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1033837000422 23S rRNA interface [nucleotide binding]; other site 1033837000423 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1033837000424 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1033837000425 core dimer interface [polypeptide binding]; other site 1033837000426 peripheral dimer interface [polypeptide binding]; other site 1033837000427 L10 interface [polypeptide binding]; other site 1033837000428 L11 interface [polypeptide binding]; other site 1033837000429 putative EF-Tu interaction site [polypeptide binding]; other site 1033837000430 putative EF-G interaction site [polypeptide binding]; other site 1033837000431 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1033837000432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033837000433 S-adenosylmethionine binding site [chemical binding]; other site 1033837000434 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1033837000435 nucleoside/Zn binding site; other site 1033837000436 dimer interface [polypeptide binding]; other site 1033837000437 catalytic motif [active] 1033837000438 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1033837000439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033837000440 Walker A motif; other site 1033837000441 ATP binding site [chemical binding]; other site 1033837000442 Walker B motif; other site 1033837000443 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1033837000444 hypothetical protein; Validated; Region: PRK00153 1033837000445 recombination protein RecR; Reviewed; Region: recR; PRK00076 1033837000446 RecR protein; Region: RecR; pfam02132 1033837000447 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1033837000448 putative active site [active] 1033837000449 putative metal-binding site [ion binding]; other site 1033837000450 tetramer interface [polypeptide binding]; other site 1033837000451 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1033837000452 thymidylate kinase; Validated; Region: tmk; PRK00698 1033837000453 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1033837000454 TMP-binding site; other site 1033837000455 ATP-binding site [chemical binding]; other site 1033837000456 Protein of unknown function (DUF970); Region: DUF970; cl17525 1033837000457 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 1033837000458 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1033837000459 Predicted methyltransferases [General function prediction only]; Region: COG0313 1033837000460 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1033837000461 putative SAM binding site [chemical binding]; other site 1033837000462 putative homodimer interface [polypeptide binding]; other site 1033837000463 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 1033837000464 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1033837000465 active site 1033837000466 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1033837000467 active site 2 [active] 1033837000468 active site 1 [active] 1033837000469 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1033837000470 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1033837000471 Glycoprotease family; Region: Peptidase_M22; pfam00814 1033837000472 UGMP family protein; Validated; Region: PRK09604 1033837000473 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1033837000474 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837000475 putative CoA-transferase; Provisional; Region: PRK11430 1033837000476 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1033837000477 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1033837000478 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1033837000479 PYR/PP interface [polypeptide binding]; other site 1033837000480 dimer interface [polypeptide binding]; other site 1033837000481 TPP binding site [chemical binding]; other site 1033837000482 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1033837000483 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1033837000484 TPP-binding site; other site 1033837000485 dimer interface [polypeptide binding]; other site 1033837000486 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1033837000487 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033837000488 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033837000489 ABC transporter; Region: ABC_tran_2; pfam12848 1033837000490 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033837000491 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1033837000492 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1033837000493 CoA binding domain; Region: CoA_binding; pfam02629 1033837000494 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1033837000495 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033837000496 DNA binding site [nucleotide binding] 1033837000497 domain linker motif; other site 1033837000498 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1033837000499 dimerization interface [polypeptide binding]; other site 1033837000500 ligand binding site [chemical binding]; other site 1033837000501 sodium binding site [ion binding]; other site 1033837000502 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1033837000503 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1033837000504 substrate binding [chemical binding]; other site 1033837000505 active site 1033837000506 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1033837000507 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1033837000508 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1033837000509 active site turn [active] 1033837000510 phosphorylation site [posttranslational modification] 1033837000511 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1033837000512 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1033837000513 HPr interaction site; other site 1033837000514 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1033837000515 active site 1033837000516 phosphorylation site [posttranslational modification] 1033837000517 Fic/DOC family; Region: Fic; cl00960 1033837000518 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1033837000519 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1033837000520 oligomerisation interface [polypeptide binding]; other site 1033837000521 mobile loop; other site 1033837000522 roof hairpin; other site 1033837000523 chaperonin GroL; Region: GroEL; TIGR02348 1033837000524 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1033837000525 ring oligomerisation interface [polypeptide binding]; other site 1033837000526 ATP/Mg binding site [chemical binding]; other site 1033837000527 stacking interactions; other site 1033837000528 hinge regions; other site 1033837000529 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1033837000530 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1033837000531 Response regulator receiver domain; Region: Response_reg; pfam00072 1033837000532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033837000533 active site 1033837000534 phosphorylation site [posttranslational modification] 1033837000535 intermolecular recognition site; other site 1033837000536 dimerization interface [polypeptide binding]; other site 1033837000537 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1033837000538 DNA binding residues [nucleotide binding] 1033837000539 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1033837000540 Histidine kinase; Region: HisKA_3; pfam07730 1033837000541 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1033837000542 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1033837000543 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1033837000544 ligand binding site [chemical binding]; other site 1033837000545 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1033837000546 active pocket/dimerization site; other site 1033837000547 active site 1033837000548 phosphorylation site [posttranslational modification] 1033837000549 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 1033837000550 active site 1033837000551 phosphorylation site [posttranslational modification] 1033837000552 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 1033837000553 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1033837000554 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1033837000555 MutS domain I; Region: MutS_I; pfam01624 1033837000556 MutS domain II; Region: MutS_II; pfam05188 1033837000557 MutS domain III; Region: MutS_III; pfam05192 1033837000558 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1033837000559 Walker A/P-loop; other site 1033837000560 ATP binding site [chemical binding]; other site 1033837000561 Q-loop/lid; other site 1033837000562 ABC transporter signature motif; other site 1033837000563 Walker B; other site 1033837000564 D-loop; other site 1033837000565 H-loop/switch region; other site 1033837000566 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1033837000567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033837000568 ATP binding site [chemical binding]; other site 1033837000569 Mg2+ binding site [ion binding]; other site 1033837000570 G-X-G motif; other site 1033837000571 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1033837000572 ATP binding site [chemical binding]; other site 1033837000573 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1033837000574 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1033837000575 RuvA N terminal domain; Region: RuvA_N; pfam01330 1033837000576 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1033837000577 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1033837000578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033837000579 Walker A motif; other site 1033837000580 ATP binding site [chemical binding]; other site 1033837000581 Walker B motif; other site 1033837000582 arginine finger; other site 1033837000583 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1033837000584 Preprotein translocase subunit; Region: YajC; pfam02699 1033837000585 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1033837000586 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1033837000587 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1033837000588 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1033837000589 active site 1033837000590 DNA polymerase IV; Validated; Region: PRK02406 1033837000591 DNA binding site [nucleotide binding] 1033837000592 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1033837000593 DHH family; Region: DHH; pfam01368 1033837000594 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1033837000595 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1033837000596 ATP binding site [chemical binding]; other site 1033837000597 putative Mg++ binding site [ion binding]; other site 1033837000598 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033837000599 nucleotide binding region [chemical binding]; other site 1033837000600 ATP-binding site [chemical binding]; other site 1033837000601 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1033837000602 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1033837000603 motif 1; other site 1033837000604 active site 1033837000605 motif 2; other site 1033837000606 motif 3; other site 1033837000607 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1033837000608 DHHA1 domain; Region: DHHA1; pfam02272 1033837000609 hypothetical protein; Provisional; Region: PRK05473 1033837000610 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1033837000611 hypothetical protein; Provisional; Region: PRK13678 1033837000612 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1033837000613 MutS domain III; Region: MutS_III; pfam05192 1033837000614 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1033837000615 Walker A/P-loop; other site 1033837000616 ATP binding site [chemical binding]; other site 1033837000617 Q-loop/lid; other site 1033837000618 ABC transporter signature motif; other site 1033837000619 Walker B; other site 1033837000620 D-loop; other site 1033837000621 H-loop/switch region; other site 1033837000622 Smr domain; Region: Smr; pfam01713 1033837000623 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1033837000624 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1033837000625 catalytic residues [active] 1033837000626 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1033837000627 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1033837000628 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1033837000629 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1033837000630 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1033837000631 active site 1033837000632 dimerization interface [polypeptide binding]; other site 1033837000633 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1033837000634 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1033837000635 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1033837000636 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1033837000637 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1033837000638 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1033837000639 active site 1033837000640 catabolite control protein A; Region: ccpA; TIGR01481 1033837000641 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033837000642 DNA binding site [nucleotide binding] 1033837000643 domain linker motif; other site 1033837000644 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1033837000645 dimerization interface [polypeptide binding]; other site 1033837000646 effector binding site; other site 1033837000647 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1033837000648 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 1033837000649 active site 1033837000650 catalytic site [active] 1033837000651 metal binding site [ion binding]; metal-binding site 1033837000652 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1033837000653 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1033837000654 active site 1033837000655 metal binding site [ion binding]; metal-binding site 1033837000656 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1033837000657 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 1033837000658 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1033837000659 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837000660 active site 1033837000661 motif I; other site 1033837000662 motif II; other site 1033837000663 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837000664 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 1033837000665 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1033837000666 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1033837000667 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1033837000668 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1033837000669 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1033837000670 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1033837000671 putative ADP-binding pocket [chemical binding]; other site 1033837000672 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1033837000673 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1033837000674 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1033837000675 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1033837000676 Sulfatase; Region: Sulfatase; pfam00884 1033837000677 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1033837000678 ribonuclease R; Region: RNase_R; TIGR02063 1033837000679 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1033837000680 RNB domain; Region: RNB; pfam00773 1033837000681 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1033837000682 RNA binding site [nucleotide binding]; other site 1033837000683 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1033837000684 SmpB-tmRNA interface; other site 1033837000685 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1033837000686 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1033837000687 intersubunit interface [polypeptide binding]; other site 1033837000688 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1033837000689 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1033837000690 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1033837000691 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1033837000692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033837000693 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1033837000694 putative substrate translocation pore; other site 1033837000695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033837000696 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1033837000697 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1033837000698 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1033837000699 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1033837000700 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1033837000701 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1033837000702 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033837000703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837000704 Walker A/P-loop; other site 1033837000705 ATP binding site [chemical binding]; other site 1033837000706 Q-loop/lid; other site 1033837000707 ABC transporter signature motif; other site 1033837000708 Walker B; other site 1033837000709 D-loop; other site 1033837000710 H-loop/switch region; other site 1033837000711 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1033837000712 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033837000713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837000714 Walker A/P-loop; other site 1033837000715 ATP binding site [chemical binding]; other site 1033837000716 Q-loop/lid; other site 1033837000717 ABC transporter signature motif; other site 1033837000718 Walker B; other site 1033837000719 D-loop; other site 1033837000720 H-loop/switch region; other site 1033837000721 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837000722 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1033837000723 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1033837000724 substrate binding pocket [chemical binding]; other site 1033837000725 chain length determination region; other site 1033837000726 substrate-Mg2+ binding site; other site 1033837000727 catalytic residues [active] 1033837000728 aspartate-rich region 1; other site 1033837000729 active site lid residues [active] 1033837000730 aspartate-rich region 2; other site 1033837000731 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1033837000732 UbiA prenyltransferase family; Region: UbiA; pfam01040 1033837000733 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1033837000734 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1033837000735 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1033837000736 active site 1033837000737 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1033837000738 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1033837000739 HIGH motif; other site 1033837000740 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1033837000741 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1033837000742 active site 1033837000743 KMSKS motif; other site 1033837000744 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1033837000745 tRNA binding surface [nucleotide binding]; other site 1033837000746 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1033837000747 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1033837000748 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 1033837000749 AAA ATPase domain; Region: AAA_16; pfam13191 1033837000750 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 1033837000751 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 1033837000752 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837000753 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1033837000754 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1033837000755 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1033837000756 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1033837000757 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1033837000758 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1033837000759 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1033837000760 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 1033837000761 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 1033837000762 PspC domain; Region: PspC; pfam04024 1033837000763 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1033837000764 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033837000765 DNA binding site [nucleotide binding] 1033837000766 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1033837000767 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1033837000768 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1033837000769 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1033837000770 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 1033837000771 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1033837000772 Melibiase; Region: Melibiase; pfam02065 1033837000773 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1033837000774 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1033837000775 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1033837000776 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1033837000777 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1033837000778 putative substrate binding site [chemical binding]; other site 1033837000779 putative ATP binding site [chemical binding]; other site 1033837000780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1033837000781 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1033837000782 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1033837000783 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1033837000784 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1033837000785 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1033837000786 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1033837000787 active site 1033837000788 HIGH motif; other site 1033837000789 KMSK motif region; other site 1033837000790 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1033837000791 tRNA binding surface [nucleotide binding]; other site 1033837000792 anticodon binding site; other site 1033837000793 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1033837000794 intersubunit interface [polypeptide binding]; other site 1033837000795 active site 1033837000796 zinc binding site [ion binding]; other site 1033837000797 Na+ binding site [ion binding]; other site 1033837000798 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1033837000799 nudix motif; other site 1033837000800 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1033837000801 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1033837000802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033837000803 active site 1033837000804 phosphorylation site [posttranslational modification] 1033837000805 intermolecular recognition site; other site 1033837000806 dimerization interface [polypeptide binding]; other site 1033837000807 LytTr DNA-binding domain; Region: LytTR; pfam04397 1033837000808 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1033837000809 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1033837000810 ligand binding site [chemical binding]; other site 1033837000811 flexible hinge region; other site 1033837000812 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1033837000813 putative switch regulator; other site 1033837000814 non-specific DNA interactions [nucleotide binding]; other site 1033837000815 DNA binding site [nucleotide binding] 1033837000816 sequence specific DNA binding site [nucleotide binding]; other site 1033837000817 putative cAMP binding site [chemical binding]; other site 1033837000818 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1033837000819 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1033837000820 metal binding site [ion binding]; metal-binding site 1033837000821 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1033837000822 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 1033837000823 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1033837000824 IHF - DNA interface [nucleotide binding]; other site 1033837000825 IHF dimer interface [polypeptide binding]; other site 1033837000826 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 1033837000827 AAA ATPase domain; Region: AAA_16; pfam13191 1033837000828 AAA domain; Region: AAA_22; pfam13401 1033837000829 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1033837000830 active site 1033837000831 substrate binding site [chemical binding]; other site 1033837000832 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1033837000833 FMN binding site [chemical binding]; other site 1033837000834 putative catalytic residues [active] 1033837000835 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1033837000836 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1033837000837 active site 1033837000838 Transglycosylase; Region: Transgly; pfam00912 1033837000839 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1033837000840 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1033837000841 hypothetical protein; Provisional; Region: PRK13676 1033837000842 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1033837000843 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1033837000844 active site 1033837000845 metal binding site [ion binding]; metal-binding site 1033837000846 DNA binding site [nucleotide binding] 1033837000847 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1033837000848 AAA domain; Region: AAA_23; pfam13476 1033837000849 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1033837000850 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1033837000851 generic binding surface I; other site 1033837000852 generic binding surface II; other site 1033837000853 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1033837000854 Zn2+ binding site [ion binding]; other site 1033837000855 Mg2+ binding site [ion binding]; other site 1033837000856 PAS domain; Region: PAS_10; pfam13596 1033837000857 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1033837000858 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1033837000859 Probable transposase; Region: OrfB_IS605; pfam01385 1033837000860 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1033837000861 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1033837000862 RelB antitoxin; Region: RelB; cl01171 1033837000863 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1033837000864 SurA N-terminal domain; Region: SurA_N_3; cl07813 1033837000865 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1033837000866 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1033837000867 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1033837000868 HIT family signature motif; other site 1033837000869 catalytic residue [active] 1033837000870 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1033837000871 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1033837000872 Walker A/P-loop; other site 1033837000873 ATP binding site [chemical binding]; other site 1033837000874 Q-loop/lid; other site 1033837000875 ABC transporter signature motif; other site 1033837000876 Walker B; other site 1033837000877 D-loop; other site 1033837000878 H-loop/switch region; other site 1033837000879 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1033837000880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033837000881 S-adenosylmethionine binding site [chemical binding]; other site 1033837000882 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1033837000883 catalytic residues [active] 1033837000884 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1033837000885 putative tRNA-binding site [nucleotide binding]; other site 1033837000886 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1033837000887 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1033837000888 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1033837000889 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1033837000890 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1033837000891 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761 1033837000892 DNA binding residues [nucleotide binding] 1033837000893 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1033837000894 catalytic residues [active] 1033837000895 catalytic nucleophile [active] 1033837000896 RelB antitoxin; Region: RelB; cl01171 1033837000897 HflC protein; Region: hflC; TIGR01932 1033837000898 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1033837000899 DNA polymerase I; Provisional; Region: PRK05755 1033837000900 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1033837000901 active site 1033837000902 metal binding site 1 [ion binding]; metal-binding site 1033837000903 putative 5' ssDNA interaction site; other site 1033837000904 metal binding site 3; metal-binding site 1033837000905 metal binding site 2 [ion binding]; metal-binding site 1033837000906 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1033837000907 putative DNA binding site [nucleotide binding]; other site 1033837000908 putative metal binding site [ion binding]; other site 1033837000909 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1033837000910 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1033837000911 active site 1033837000912 DNA binding site [nucleotide binding] 1033837000913 catalytic site [active] 1033837000914 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1033837000915 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1033837000916 DNA binding site [nucleotide binding] 1033837000917 catalytic residue [active] 1033837000918 H2TH interface [polypeptide binding]; other site 1033837000919 putative catalytic residues [active] 1033837000920 turnover-facilitating residue; other site 1033837000921 intercalation triad [nucleotide binding]; other site 1033837000922 8OG recognition residue [nucleotide binding]; other site 1033837000923 putative reading head residues; other site 1033837000924 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1033837000925 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1033837000926 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1033837000927 dephospho-CoA kinase; Region: TIGR00152 1033837000928 CoA-binding site [chemical binding]; other site 1033837000929 ATP-binding [chemical binding]; other site 1033837000930 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1033837000931 ATP cone domain; Region: ATP-cone; pfam03477 1033837000932 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1033837000933 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1033837000934 primosomal protein DnaI; Reviewed; Region: PRK08939 1033837000935 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1033837000936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033837000937 Walker A motif; other site 1033837000938 ATP binding site [chemical binding]; other site 1033837000939 Walker B motif; other site 1033837000940 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1033837000941 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1033837000942 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1033837000943 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1033837000944 active site 1033837000945 dimer interface [polypeptide binding]; other site 1033837000946 motif 1; other site 1033837000947 motif 2; other site 1033837000948 motif 3; other site 1033837000949 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1033837000950 anticodon binding site; other site 1033837000951 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1033837000952 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1033837000953 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1033837000954 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1033837000955 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1033837000956 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1033837000957 23S rRNA binding site [nucleotide binding]; other site 1033837000958 L21 binding site [polypeptide binding]; other site 1033837000959 L13 binding site [polypeptide binding]; other site 1033837000960 adenosine deaminase; Provisional; Region: PRK09358 1033837000961 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1033837000962 active site 1033837000963 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 1033837000964 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837000965 active site 1033837000966 motif I; other site 1033837000967 motif II; other site 1033837000968 GTPase YqeH; Provisional; Region: PRK13796 1033837000969 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1033837000970 GTP/Mg2+ binding site [chemical binding]; other site 1033837000971 G4 box; other site 1033837000972 G5 box; other site 1033837000973 G1 box; other site 1033837000974 Switch I region; other site 1033837000975 G2 box; other site 1033837000976 G3 box; other site 1033837000977 Switch II region; other site 1033837000978 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1033837000979 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1033837000980 active site 1033837000981 (T/H)XGH motif; other site 1033837000982 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1033837000983 Zn2+ binding site [ion binding]; other site 1033837000984 Mg2+ binding site [ion binding]; other site 1033837000985 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1033837000986 hypothetical protein; Provisional; Region: PRK13670 1033837000987 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1033837000988 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1033837000989 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1033837000990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033837000991 active site 1033837000992 phosphorylation site [posttranslational modification] 1033837000993 intermolecular recognition site; other site 1033837000994 dimerization interface [polypeptide binding]; other site 1033837000995 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033837000996 DNA binding site [nucleotide binding] 1033837000997 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1033837000998 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1033837000999 dimerization interface [polypeptide binding]; other site 1033837001000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033837001001 dimer interface [polypeptide binding]; other site 1033837001002 phosphorylation site [posttranslational modification] 1033837001003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033837001004 ATP binding site [chemical binding]; other site 1033837001005 Mg2+ binding site [ion binding]; other site 1033837001006 G-X-G motif; other site 1033837001007 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1033837001008 putative deacylase active site [active] 1033837001009 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1033837001010 Acylphosphatase; Region: Acylphosphatase; pfam00708 1033837001011 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1033837001012 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1033837001013 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1033837001014 Predicted transcriptional regulators [Transcription]; Region: COG1733 1033837001015 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1033837001016 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1033837001017 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1033837001018 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1033837001019 dimer interface [polypeptide binding]; other site 1033837001020 motif 1; other site 1033837001021 active site 1033837001022 motif 2; other site 1033837001023 motif 3; other site 1033837001024 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1033837001025 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1033837001026 putative tRNA-binding site [nucleotide binding]; other site 1033837001027 B3/4 domain; Region: B3_4; pfam03483 1033837001028 tRNA synthetase B5 domain; Region: B5; smart00874 1033837001029 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1033837001030 dimer interface [polypeptide binding]; other site 1033837001031 motif 1; other site 1033837001032 motif 3; other site 1033837001033 motif 2; other site 1033837001034 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1033837001035 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1033837001036 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1033837001037 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1033837001038 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1033837001039 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1033837001040 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1033837001041 NAD binding site [chemical binding]; other site 1033837001042 dimer interface [polypeptide binding]; other site 1033837001043 substrate binding site [chemical binding]; other site 1033837001044 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1033837001045 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1033837001046 nucleotide binding site [chemical binding]; other site 1033837001047 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1033837001048 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1033837001049 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1033837001050 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1033837001051 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1033837001052 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1033837001053 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1033837001054 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1033837001055 Rhomboid family; Region: Rhomboid; pfam01694 1033837001056 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1033837001057 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1033837001058 active site residue [active] 1033837001059 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1033837001060 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1033837001061 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1033837001062 Aluminium resistance protein; Region: Alum_res; pfam06838 1033837001063 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1033837001064 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1033837001065 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1033837001066 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1033837001067 Helix-turn-helix domain; Region: HTH_28; pfam13518 1033837001068 putative transposase OrfB; Reviewed; Region: PHA02517 1033837001069 HTH-like domain; Region: HTH_21; pfam13276 1033837001070 Integrase core domain; Region: rve; pfam00665 1033837001071 Integrase core domain; Region: rve_2; pfam13333 1033837001072 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1033837001073 propionate/acetate kinase; Provisional; Region: PRK12379 1033837001074 RelB antitoxin; Region: RelB; cl01171 1033837001075 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1033837001076 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1033837001077 Probable transposase; Region: OrfB_IS605; pfam01385 1033837001078 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1033837001079 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1033837001080 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1033837001081 NAD binding site [chemical binding]; other site 1033837001082 homodimer interface [polypeptide binding]; other site 1033837001083 active site 1033837001084 substrate binding site [chemical binding]; other site 1033837001085 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1033837001086 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1033837001087 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1033837001088 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1033837001089 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1033837001090 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033837001091 DNA binding site [nucleotide binding] 1033837001092 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1033837001093 putative dimerization interface [polypeptide binding]; other site 1033837001094 putative ligand binding site [chemical binding]; other site 1033837001095 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1033837001096 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1033837001097 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1033837001098 HPr interaction site; other site 1033837001099 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1033837001100 active site 1033837001101 phosphorylation site [posttranslational modification] 1033837001102 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1033837001103 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1033837001104 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1033837001105 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1033837001106 galactokinase; Provisional; Region: PRK05322 1033837001107 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1033837001108 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1033837001109 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1033837001110 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1033837001111 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1033837001112 active site 1033837001113 catalytic residues [active] 1033837001114 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1033837001115 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1033837001116 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033837001117 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1033837001118 Melibiase; Region: Melibiase; pfam02065 1033837001119 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1033837001120 synthetase active site [active] 1033837001121 NTP binding site [chemical binding]; other site 1033837001122 metal binding site [ion binding]; metal-binding site 1033837001123 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1033837001124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033837001125 active site 1033837001126 phosphorylation site [posttranslational modification] 1033837001127 intermolecular recognition site; other site 1033837001128 dimerization interface [polypeptide binding]; other site 1033837001129 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033837001130 DNA binding site [nucleotide binding] 1033837001131 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1033837001132 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033837001133 dimer interface [polypeptide binding]; other site 1033837001134 phosphorylation site [posttranslational modification] 1033837001135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033837001136 ATP binding site [chemical binding]; other site 1033837001137 Mg2+ binding site [ion binding]; other site 1033837001138 G-X-G motif; other site 1033837001139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033837001140 putative substrate translocation pore; other site 1033837001141 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1033837001142 OsmC-like protein; Region: OsmC; pfam02566 1033837001143 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1033837001144 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1033837001145 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1033837001146 Double zinc ribbon; Region: DZR; pfam12773 1033837001147 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1033837001148 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1033837001149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1033837001150 SH3-like domain; Region: SH3_8; pfam13457 1033837001151 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1033837001152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1033837001153 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1033837001154 Probable transposase; Region: OrfB_IS605; pfam01385 1033837001155 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1033837001156 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 1033837001157 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1033837001158 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1033837001159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837001160 Q-loop/lid; other site 1033837001161 ABC transporter signature motif; other site 1033837001162 Walker B; other site 1033837001163 D-loop; other site 1033837001164 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1033837001165 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033837001166 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033837001167 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1033837001168 ATP binding site [chemical binding]; other site 1033837001169 substrate interface [chemical binding]; other site 1033837001170 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1033837001171 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033837001172 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1033837001173 Walker A/P-loop; other site 1033837001174 ATP binding site [chemical binding]; other site 1033837001175 Q-loop/lid; other site 1033837001176 ABC transporter signature motif; other site 1033837001177 Walker B; other site 1033837001178 D-loop; other site 1033837001179 H-loop/switch region; other site 1033837001180 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1033837001181 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1033837001182 Integrase core domain; Region: rve; pfam00665 1033837001183 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1033837001184 MULE transposase domain; Region: MULE; pfam10551 1033837001185 RelB antitoxin; Region: RelB; cl01171 1033837001186 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033837001187 active site 1033837001188 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1033837001189 active site 1033837001190 dimer interface [polypeptide binding]; other site 1033837001191 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1033837001192 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1033837001193 heterodimer interface [polypeptide binding]; other site 1033837001194 active site 1033837001195 FMN binding site [chemical binding]; other site 1033837001196 homodimer interface [polypeptide binding]; other site 1033837001197 substrate binding site [chemical binding]; other site 1033837001198 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1033837001199 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033837001200 active site 1033837001201 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1033837001202 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1033837001203 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1033837001204 dihydroorotase; Validated; Region: pyrC; PRK09357 1033837001205 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1033837001206 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1033837001207 active site 1033837001208 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1033837001209 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1033837001210 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1033837001211 catalytic site [active] 1033837001212 subunit interface [polypeptide binding]; other site 1033837001213 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1033837001214 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1033837001215 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1033837001216 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1033837001217 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1033837001218 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1033837001219 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1033837001220 IMP binding site; other site 1033837001221 dimer interface [polypeptide binding]; other site 1033837001222 partial ornithine binding site; other site 1033837001223 Domain of unknown function (DUF955); Region: DUF955; cl01076 1033837001224 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 1033837001225 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1033837001226 SelR domain; Region: SelR; pfam01641 1033837001227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033837001228 Coenzyme A binding pocket [chemical binding]; other site 1033837001229 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1033837001230 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 1033837001231 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 1033837001232 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1033837001233 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 1033837001234 active site 1033837001235 Zn binding site [ion binding]; other site 1033837001236 hypothetical protein; Provisional; Region: PRK06762 1033837001237 AAA domain; Region: AAA_33; pfam13671 1033837001238 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1033837001239 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1033837001240 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1033837001241 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1033837001242 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 1033837001243 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1033837001244 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033837001245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837001246 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1033837001247 Walker A/P-loop; other site 1033837001248 ATP binding site [chemical binding]; other site 1033837001249 Q-loop/lid; other site 1033837001250 ABC transporter signature motif; other site 1033837001251 Walker B; other site 1033837001252 D-loop; other site 1033837001253 H-loop/switch region; other site 1033837001254 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033837001255 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1033837001256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837001257 Walker A/P-loop; other site 1033837001258 ATP binding site [chemical binding]; other site 1033837001259 Q-loop/lid; other site 1033837001260 ABC transporter signature motif; other site 1033837001261 Walker B; other site 1033837001262 TIGR02452 family protein; Region: TIGR02452 1033837001263 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 1033837001264 Short C-terminal domain; Region: SHOCT; pfam09851 1033837001265 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1033837001266 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1033837001267 substrate binding pocket [chemical binding]; other site 1033837001268 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 1033837001269 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1033837001270 active site 1033837001271 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837001272 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1033837001273 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1033837001274 TAP-like protein; Region: Abhydrolase_4; pfam08386 1033837001275 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1033837001276 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 1033837001277 active site 1 [active] 1033837001278 dimer interface [polypeptide binding]; other site 1033837001279 hexamer interface [polypeptide binding]; other site 1033837001280 active site 2 [active] 1033837001281 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1033837001282 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1033837001283 homodimer interface [polypeptide binding]; other site 1033837001284 substrate-cofactor binding pocket; other site 1033837001285 catalytic residue [active] 1033837001286 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 1033837001287 PLD-like domain; Region: PLDc_2; pfam13091 1033837001288 homodimer interface [polypeptide binding]; other site 1033837001289 putative active site [active] 1033837001290 catalytic site [active] 1033837001291 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1033837001292 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1033837001293 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1033837001294 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1033837001295 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1033837001296 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1033837001297 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1033837001298 active site 1033837001299 elongation factor P; Validated; Region: PRK00529 1033837001300 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1033837001301 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1033837001302 RNA binding site [nucleotide binding]; other site 1033837001303 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1033837001304 RNA binding site [nucleotide binding]; other site 1033837001305 Asp23 family; Region: Asp23; pfam03780 1033837001306 transcription antitermination factor NusB; Region: nusB; TIGR01951 1033837001307 putative RNA binding site [nucleotide binding]; other site 1033837001308 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1033837001309 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1033837001310 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1033837001311 homodimer interface [polypeptide binding]; other site 1033837001312 NADP binding site [chemical binding]; other site 1033837001313 substrate binding site [chemical binding]; other site 1033837001314 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1033837001315 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1033837001316 generic binding surface II; other site 1033837001317 generic binding surface I; other site 1033837001318 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1033837001319 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1033837001320 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1033837001321 substrate binding pocket [chemical binding]; other site 1033837001322 chain length determination region; other site 1033837001323 substrate-Mg2+ binding site; other site 1033837001324 catalytic residues [active] 1033837001325 aspartate-rich region 1; other site 1033837001326 active site lid residues [active] 1033837001327 aspartate-rich region 2; other site 1033837001328 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1033837001329 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1033837001330 RNA binding surface [nucleotide binding]; other site 1033837001331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033837001332 S-adenosylmethionine binding site [chemical binding]; other site 1033837001333 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1033837001334 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1033837001335 Walker A/P-loop; other site 1033837001336 ATP binding site [chemical binding]; other site 1033837001337 Q-loop/lid; other site 1033837001338 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1033837001339 ABC transporter signature motif; other site 1033837001340 Walker B; other site 1033837001341 D-loop; other site 1033837001342 H-loop/switch region; other site 1033837001343 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1033837001344 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1033837001345 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1033837001346 catalytic site [active] 1033837001347 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1033837001348 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1033837001349 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033837001350 ATP binding site [chemical binding]; other site 1033837001351 putative Mg++ binding site [ion binding]; other site 1033837001352 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033837001353 nucleotide binding region [chemical binding]; other site 1033837001354 ATP-binding site [chemical binding]; other site 1033837001355 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1033837001356 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1033837001357 putative active site [active] 1033837001358 substrate binding site [chemical binding]; other site 1033837001359 putative cosubstrate binding site; other site 1033837001360 catalytic site [active] 1033837001361 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1033837001362 substrate binding site [chemical binding]; other site 1033837001363 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1033837001364 NusB family; Region: NusB; pfam01029 1033837001365 putative RNA binding site [nucleotide binding]; other site 1033837001366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033837001367 S-adenosylmethionine binding site [chemical binding]; other site 1033837001368 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1033837001369 Protein phosphatase 2C; Region: PP2C; pfam00481 1033837001370 active site 1033837001371 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1033837001372 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1033837001373 active site 1033837001374 ATP binding site [chemical binding]; other site 1033837001375 substrate binding site [chemical binding]; other site 1033837001376 activation loop (A-loop); other site 1033837001377 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1033837001378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1033837001379 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1033837001380 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1033837001381 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1033837001382 GTPase RsgA; Reviewed; Region: PRK00098 1033837001383 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1033837001384 RNA binding site [nucleotide binding]; other site 1033837001385 homodimer interface [polypeptide binding]; other site 1033837001386 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1033837001387 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1033837001388 GTP/Mg2+ binding site [chemical binding]; other site 1033837001389 G4 box; other site 1033837001390 G1 box; other site 1033837001391 Switch I region; other site 1033837001392 G2 box; other site 1033837001393 G3 box; other site 1033837001394 Switch II region; other site 1033837001395 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1033837001396 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1033837001397 substrate binding site [chemical binding]; other site 1033837001398 hexamer interface [polypeptide binding]; other site 1033837001399 metal binding site [ion binding]; metal-binding site 1033837001400 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1033837001401 Thiamine pyrophosphokinase; Region: TPK; cd07995 1033837001402 active site 1033837001403 dimerization interface [polypeptide binding]; other site 1033837001404 thiamine binding site [chemical binding]; other site 1033837001405 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1033837001406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1033837001407 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1033837001408 DAK2 domain; Region: Dak2; pfam02734 1033837001409 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1033837001410 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1033837001411 ssDNA binding site; other site 1033837001412 generic binding surface II; other site 1033837001413 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033837001414 ATP binding site [chemical binding]; other site 1033837001415 putative Mg++ binding site [ion binding]; other site 1033837001416 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033837001417 nucleotide binding region [chemical binding]; other site 1033837001418 ATP-binding site [chemical binding]; other site 1033837001419 putative phosphate acyltransferase; Provisional; Region: PRK05331 1033837001420 acyl carrier protein; Provisional; Region: acpP; PRK00982 1033837001421 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1033837001422 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033837001423 Walker A/P-loop; other site 1033837001424 ATP binding site [chemical binding]; other site 1033837001425 Q-loop/lid; other site 1033837001426 ABC transporter signature motif; other site 1033837001427 Walker B; other site 1033837001428 D-loop; other site 1033837001429 H-loop/switch region; other site 1033837001430 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1033837001431 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033837001432 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1033837001433 Walker A/P-loop; other site 1033837001434 ATP binding site [chemical binding]; other site 1033837001435 Q-loop/lid; other site 1033837001436 ABC transporter signature motif; other site 1033837001437 Walker B; other site 1033837001438 D-loop; other site 1033837001439 H-loop/switch region; other site 1033837001440 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1033837001441 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1033837001442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837001443 dimer interface [polypeptide binding]; other site 1033837001444 conserved gate region; other site 1033837001445 putative PBP binding loops; other site 1033837001446 ABC-ATPase subunit interface; other site 1033837001447 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1033837001448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837001449 dimer interface [polypeptide binding]; other site 1033837001450 conserved gate region; other site 1033837001451 putative PBP binding loops; other site 1033837001452 ABC-ATPase subunit interface; other site 1033837001453 ribonuclease III; Reviewed; Region: rnc; PRK00102 1033837001454 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1033837001455 dimerization interface [polypeptide binding]; other site 1033837001456 active site 1033837001457 metal binding site [ion binding]; metal-binding site 1033837001458 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1033837001459 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1033837001460 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1033837001461 Walker A/P-loop; other site 1033837001462 ATP binding site [chemical binding]; other site 1033837001463 Q-loop/lid; other site 1033837001464 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1033837001465 Nucleoporin complex subunit 54; Region: Nup54; pfam13874 1033837001466 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1033837001467 ABC transporter signature motif; other site 1033837001468 Walker B; other site 1033837001469 D-loop; other site 1033837001470 H-loop/switch region; other site 1033837001471 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1033837001472 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1033837001473 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1033837001474 P loop; other site 1033837001475 GTP binding site [chemical binding]; other site 1033837001476 Peptidase family C69; Region: Peptidase_C69; pfam03577 1033837001477 amino acid transporter; Region: 2A0306; TIGR00909 1033837001478 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1033837001479 putative DNA-binding protein; Validated; Region: PRK00118 1033837001480 signal recognition particle protein; Provisional; Region: PRK10867 1033837001481 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1033837001482 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1033837001483 P loop; other site 1033837001484 GTP binding site [chemical binding]; other site 1033837001485 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1033837001486 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1033837001487 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1033837001488 RimM N-terminal domain; Region: RimM; pfam01782 1033837001489 PRC-barrel domain; Region: PRC; pfam05239 1033837001490 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1033837001491 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1033837001492 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1033837001493 active site 1033837001494 Fe-S cluster binding site [ion binding]; other site 1033837001495 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1033837001496 active site 1033837001497 catalytic triad [active] 1033837001498 oxyanion hole [active] 1033837001499 LexA repressor; Validated; Region: PRK00215 1033837001500 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1033837001501 putative DNA binding site [nucleotide binding]; other site 1033837001502 putative Zn2+ binding site [ion binding]; other site 1033837001503 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1033837001504 Catalytic site [active] 1033837001505 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1033837001506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1033837001507 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1033837001508 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1033837001509 active site 1033837001510 Zn binding site [ion binding]; other site 1033837001511 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1033837001512 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1033837001513 putative acyl-acceptor binding pocket; other site 1033837001514 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1033837001515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033837001516 S-adenosylmethionine binding site [chemical binding]; other site 1033837001517 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1033837001518 GIY-YIG motif/motif A; other site 1033837001519 putative active site [active] 1033837001520 putative metal binding site [ion binding]; other site 1033837001521 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1033837001522 rRNA interaction site [nucleotide binding]; other site 1033837001523 S8 interaction site; other site 1033837001524 putative laminin-1 binding site; other site 1033837001525 elongation factor Ts; Provisional; Region: tsf; PRK09377 1033837001526 UBA/TS-N domain; Region: UBA; pfam00627 1033837001527 Elongation factor TS; Region: EF_TS; pfam00889 1033837001528 Elongation factor TS; Region: EF_TS; pfam00889 1033837001529 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1033837001530 putative nucleotide binding site [chemical binding]; other site 1033837001531 uridine monophosphate binding site [chemical binding]; other site 1033837001532 homohexameric interface [polypeptide binding]; other site 1033837001533 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1033837001534 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1033837001535 hinge region; other site 1033837001536 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 1033837001537 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1033837001538 catalytic residue [active] 1033837001539 putative FPP diphosphate binding site; other site 1033837001540 putative FPP binding hydrophobic cleft; other site 1033837001541 dimer interface [polypeptide binding]; other site 1033837001542 putative IPP diphosphate binding site; other site 1033837001543 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1033837001544 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1033837001545 RIP metalloprotease RseP; Region: TIGR00054 1033837001546 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1033837001547 active site 1033837001548 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1033837001549 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1033837001550 protein binding site [polypeptide binding]; other site 1033837001551 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1033837001552 putative substrate binding region [chemical binding]; other site 1033837001553 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1033837001554 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1033837001555 dimer interface [polypeptide binding]; other site 1033837001556 motif 1; other site 1033837001557 active site 1033837001558 motif 2; other site 1033837001559 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1033837001560 putative deacylase active site [active] 1033837001561 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1033837001562 active site 1033837001563 motif 3; other site 1033837001564 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1033837001565 anticodon binding site; other site 1033837001566 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1033837001567 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1033837001568 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1033837001569 generic binding surface II; other site 1033837001570 generic binding surface I; other site 1033837001571 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1033837001572 active site 1033837001573 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1033837001574 active site 1033837001575 catalytic site [active] 1033837001576 substrate binding site [chemical binding]; other site 1033837001577 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1033837001578 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1033837001579 Sm and related proteins; Region: Sm_like; cl00259 1033837001580 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1033837001581 putative oligomer interface [polypeptide binding]; other site 1033837001582 putative RNA binding site [nucleotide binding]; other site 1033837001583 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1033837001584 NusA N-terminal domain; Region: NusA_N; pfam08529 1033837001585 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1033837001586 RNA binding site [nucleotide binding]; other site 1033837001587 homodimer interface [polypeptide binding]; other site 1033837001588 NusA-like KH domain; Region: KH_5; pfam13184 1033837001589 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1033837001590 G-X-X-G motif; other site 1033837001591 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1033837001592 putative RNA binding cleft [nucleotide binding]; other site 1033837001593 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1033837001594 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1033837001595 translation initiation factor IF-2; Validated; Region: infB; PRK05306 1033837001596 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1033837001597 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1033837001598 G1 box; other site 1033837001599 putative GEF interaction site [polypeptide binding]; other site 1033837001600 GTP/Mg2+ binding site [chemical binding]; other site 1033837001601 Switch I region; other site 1033837001602 G2 box; other site 1033837001603 G3 box; other site 1033837001604 Switch II region; other site 1033837001605 G4 box; other site 1033837001606 G5 box; other site 1033837001607 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1033837001608 Translation-initiation factor 2; Region: IF-2; pfam11987 1033837001609 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1033837001610 Ribosome-binding factor A; Region: RBFA; cl00542 1033837001611 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 1033837001612 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1033837001613 RNA binding site [nucleotide binding]; other site 1033837001614 active site 1033837001615 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1033837001616 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1033837001617 active site 1033837001618 Riboflavin kinase; Region: Flavokinase; smart00904 1033837001619 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1033837001620 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1033837001621 GrpE; Region: GrpE; pfam01025 1033837001622 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1033837001623 dimer interface [polypeptide binding]; other site 1033837001624 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1033837001625 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1033837001626 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1033837001627 nucleotide binding site [chemical binding]; other site 1033837001628 NEF interaction site [polypeptide binding]; other site 1033837001629 SBD interface [polypeptide binding]; other site 1033837001630 chaperone protein DnaJ; Provisional; Region: PRK14276 1033837001631 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1033837001632 HSP70 interaction site [polypeptide binding]; other site 1033837001633 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1033837001634 substrate binding site [polypeptide binding]; other site 1033837001635 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1033837001636 Zn binding sites [ion binding]; other site 1033837001637 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1033837001638 dimer interface [polypeptide binding]; other site 1033837001639 GTP-binding protein LepA; Provisional; Region: PRK05433 1033837001640 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1033837001641 G1 box; other site 1033837001642 putative GEF interaction site [polypeptide binding]; other site 1033837001643 GTP/Mg2+ binding site [chemical binding]; other site 1033837001644 Switch I region; other site 1033837001645 G2 box; other site 1033837001646 G3 box; other site 1033837001647 Switch II region; other site 1033837001648 G4 box; other site 1033837001649 G5 box; other site 1033837001650 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1033837001651 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1033837001652 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1033837001653 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1033837001654 active site 1033837001655 catalytic site [active] 1033837001656 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1033837001657 DHH family; Region: DHH; pfam01368 1033837001658 DHHA1 domain; Region: DHHA1; pfam02272 1033837001659 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 1033837001660 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033837001661 active site 1033837001662 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1033837001663 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1033837001664 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1033837001665 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1033837001666 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1033837001667 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1033837001668 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1033837001669 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1033837001670 dimer interface [polypeptide binding]; other site 1033837001671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033837001672 catalytic residue [active] 1033837001673 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1033837001674 conserved cys residue [active] 1033837001675 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1033837001676 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 1033837001677 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1033837001678 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837001679 motif II; other site 1033837001680 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1033837001681 arginine deiminase; Provisional; Region: PRK01388 1033837001682 ornithine carbamoyltransferase; Validated; Region: PRK02102 1033837001683 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1033837001684 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1033837001685 carbamate kinase; Reviewed; Region: PRK12686 1033837001686 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1033837001687 putative substrate binding site [chemical binding]; other site 1033837001688 nucleotide binding site [chemical binding]; other site 1033837001689 nucleotide binding site [chemical binding]; other site 1033837001690 homodimer interface [polypeptide binding]; other site 1033837001691 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 1033837001692 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1033837001693 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1033837001694 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1033837001695 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1033837001696 dimerization interface [polypeptide binding]; other site 1033837001697 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1033837001698 aspartate kinase; Reviewed; Region: PRK09034 1033837001699 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1033837001700 putative catalytic residues [active] 1033837001701 putative nucleotide binding site [chemical binding]; other site 1033837001702 putative aspartate binding site [chemical binding]; other site 1033837001703 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1033837001704 allosteric regulatory residue; other site 1033837001705 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1033837001706 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1033837001707 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1033837001708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033837001709 catalytic residue [active] 1033837001710 homoserine dehydrogenase; Provisional; Region: PRK06349 1033837001711 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1033837001712 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1033837001713 homoserine kinase; Provisional; Region: PRK01212 1033837001714 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1033837001715 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1033837001716 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1033837001717 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1033837001718 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1033837001719 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1033837001720 Peptidase family M23; Region: Peptidase_M23; pfam01551 1033837001721 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 1033837001722 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1033837001723 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1033837001724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1033837001725 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1033837001726 Yqey-like protein; Region: YqeY; pfam09424 1033837001727 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1033837001728 PhoH-like protein; Region: PhoH; pfam02562 1033837001729 metal-binding heat shock protein; Provisional; Region: PRK00016 1033837001730 GTPase Era; Reviewed; Region: era; PRK00089 1033837001731 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1033837001732 G1 box; other site 1033837001733 GTP/Mg2+ binding site [chemical binding]; other site 1033837001734 Switch I region; other site 1033837001735 G2 box; other site 1033837001736 Switch II region; other site 1033837001737 G3 box; other site 1033837001738 G4 box; other site 1033837001739 G5 box; other site 1033837001740 KH domain; Region: KH_2; pfam07650 1033837001741 Recombination protein O N terminal; Region: RecO_N; pfam11967 1033837001742 DNA repair protein RecO; Region: reco; TIGR00613 1033837001743 Recombination protein O C terminal; Region: RecO_C; pfam02565 1033837001744 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 1033837001745 motif 1; other site 1033837001746 dimer interface [polypeptide binding]; other site 1033837001747 active site 1033837001748 motif 2; other site 1033837001749 motif 3; other site 1033837001750 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1033837001751 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1033837001752 DNA primase; Validated; Region: dnaG; PRK05667 1033837001753 CHC2 zinc finger; Region: zf-CHC2; cl17510 1033837001754 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1033837001755 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1033837001756 active site 1033837001757 metal binding site [ion binding]; metal-binding site 1033837001758 interdomain interaction site; other site 1033837001759 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1033837001760 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1033837001761 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1033837001762 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1033837001763 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1033837001764 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1033837001765 DNA binding residues [nucleotide binding] 1033837001766 Peptidase family M23; Region: Peptidase_M23; pfam01551 1033837001767 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1033837001768 putative active site [active] 1033837001769 nucleotide binding site [chemical binding]; other site 1033837001770 nudix motif; other site 1033837001771 putative metal binding site [ion binding]; other site 1033837001772 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1033837001773 Family of unknown function (DUF633); Region: DUF633; pfam04816 1033837001774 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1033837001775 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1033837001776 Predicted transcriptional regulators [Transcription]; Region: COG1725 1033837001777 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033837001778 DNA-binding site [nucleotide binding]; DNA binding site 1033837001779 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1033837001780 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1033837001781 Walker A/P-loop; other site 1033837001782 ATP binding site [chemical binding]; other site 1033837001783 Q-loop/lid; other site 1033837001784 ABC transporter signature motif; other site 1033837001785 Walker B; other site 1033837001786 D-loop; other site 1033837001787 H-loop/switch region; other site 1033837001788 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1033837001789 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1033837001790 Catalytic site [active] 1033837001791 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1033837001792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033837001793 S-adenosylmethionine binding site [chemical binding]; other site 1033837001794 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1033837001795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837001796 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1033837001797 active site 1033837001798 motif I; other site 1033837001799 motif II; other site 1033837001800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837001801 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1033837001802 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1033837001803 homotetramer interface [polypeptide binding]; other site 1033837001804 FMN binding site [chemical binding]; other site 1033837001805 homodimer contacts [polypeptide binding]; other site 1033837001806 putative active site [active] 1033837001807 putative substrate binding site [chemical binding]; other site 1033837001808 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1033837001809 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1033837001810 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1033837001811 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1033837001812 diphosphomevalonate decarboxylase; Region: PLN02407 1033837001813 mevalonate kinase; Region: mevalon_kin; TIGR00549 1033837001814 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1033837001815 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1033837001816 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1033837001817 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1033837001818 Part of AAA domain; Region: AAA_19; pfam13245 1033837001819 Family description; Region: UvrD_C_2; pfam13538 1033837001820 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1033837001821 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1033837001822 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1033837001823 active site 1033837001824 catalytic site [active] 1033837001825 substrate binding site [chemical binding]; other site 1033837001826 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033837001827 ATP binding site [chemical binding]; other site 1033837001828 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1033837001829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1033837001830 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1033837001831 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1033837001832 putative dimer interface [polypeptide binding]; other site 1033837001833 putative anticodon binding site; other site 1033837001834 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1033837001835 homodimer interface [polypeptide binding]; other site 1033837001836 motif 1; other site 1033837001837 motif 2; other site 1033837001838 active site 1033837001839 motif 3; other site 1033837001840 Helix-turn-helix domain; Region: HTH_36; pfam13730 1033837001841 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1033837001842 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1033837001843 endonuclease III; Region: ENDO3c; smart00478 1033837001844 minor groove reading motif; other site 1033837001845 helix-hairpin-helix signature motif; other site 1033837001846 substrate binding pocket [chemical binding]; other site 1033837001847 active site 1033837001848 Transglycosylase; Region: Transgly; pfam00912 1033837001849 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1033837001850 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1033837001851 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1033837001852 hypothetical protein; Provisional; Region: PRK13660 1033837001853 DivIVA protein; Region: DivIVA; pfam05103 1033837001854 DivIVA domain; Region: DivI1A_domain; TIGR03544 1033837001855 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1033837001856 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1033837001857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1033837001858 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1033837001859 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1033837001860 active site 1033837001861 metal binding site [ion binding]; metal-binding site 1033837001862 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1033837001863 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1033837001864 Potassium binding sites [ion binding]; other site 1033837001865 Cesium cation binding sites [ion binding]; other site 1033837001866 lipoprotein signal peptidase; Provisional; Region: PRK14797 1033837001867 lipoprotein signal peptidase; Provisional; Region: PRK14787 1033837001868 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1033837001869 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1033837001870 RNA binding surface [nucleotide binding]; other site 1033837001871 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1033837001872 active site 1033837001873 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1033837001874 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1033837001875 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1033837001876 catalytic site [active] 1033837001877 subunit interface [polypeptide binding]; other site 1033837001878 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1033837001879 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1033837001880 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1033837001881 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1033837001882 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1033837001883 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1033837001884 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1033837001885 IMP binding site; other site 1033837001886 dimer interface [polypeptide binding]; other site 1033837001887 interdomain contacts; other site 1033837001888 partial ornithine binding site; other site 1033837001889 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1033837001890 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1033837001891 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1033837001892 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1033837001893 EDD domain protein, DegV family; Region: DegV; TIGR00762 1033837001894 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1033837001895 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1033837001896 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033837001897 active site 1033837001898 DNA binding site [nucleotide binding] 1033837001899 Int/Topo IB signature motif; other site 1033837001900 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 1033837001901 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1033837001902 active site 1033837001903 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837001904 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837001905 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 1033837001906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837001907 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1033837001908 active site 1033837001909 motif I; other site 1033837001910 motif II; other site 1033837001911 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1033837001912 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033837001913 non-specific DNA binding site [nucleotide binding]; other site 1033837001914 salt bridge; other site 1033837001915 sequence-specific DNA binding site [nucleotide binding]; other site 1033837001916 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1033837001917 active site 1033837001918 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1033837001919 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1033837001920 DHHA2 domain; Region: DHHA2; pfam02833 1033837001921 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1033837001922 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033837001923 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1033837001924 dimerization interface [polypeptide binding]; other site 1033837001925 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1033837001926 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1033837001927 CAP-like domain; other site 1033837001928 active site 1033837001929 primary dimer interface [polypeptide binding]; other site 1033837001930 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1033837001931 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1033837001932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033837001933 Mg2+ binding site [ion binding]; other site 1033837001934 G-X-G motif; other site 1033837001935 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1033837001936 anchoring element; other site 1033837001937 dimer interface [polypeptide binding]; other site 1033837001938 ATP binding site [chemical binding]; other site 1033837001939 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1033837001940 active site 1033837001941 putative metal-binding site [ion binding]; other site 1033837001942 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1033837001943 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1033837001944 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1033837001945 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1033837001946 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033837001947 ATP binding site [chemical binding]; other site 1033837001948 putative Mg++ binding site [ion binding]; other site 1033837001949 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1033837001950 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033837001951 nucleotide binding region [chemical binding]; other site 1033837001952 ATP-binding site [chemical binding]; other site 1033837001953 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1033837001954 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1033837001955 endonuclease III; Region: ENDO3c; smart00478 1033837001956 minor groove reading motif; other site 1033837001957 helix-hairpin-helix signature motif; other site 1033837001958 substrate binding pocket [chemical binding]; other site 1033837001959 active site 1033837001960 LytTr DNA-binding domain; Region: LytTR; smart00850 1033837001961 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1033837001962 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1033837001963 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1033837001964 dimerization interface [polypeptide binding]; other site 1033837001965 DPS ferroxidase diiron center [ion binding]; other site 1033837001966 ion pore; other site 1033837001967 topology modulation protein; Reviewed; Region: PRK08118 1033837001968 AAA domain; Region: AAA_17; pfam13207 1033837001969 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1033837001970 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1033837001971 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 1033837001972 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1033837001973 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1033837001974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837001975 Walker A/P-loop; other site 1033837001976 ATP binding site [chemical binding]; other site 1033837001977 Q-loop/lid; other site 1033837001978 ABC transporter signature motif; other site 1033837001979 Walker B; other site 1033837001980 D-loop; other site 1033837001981 H-loop/switch region; other site 1033837001982 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1033837001983 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1033837001984 active site 1033837001985 metal binding site [ion binding]; metal-binding site 1033837001986 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1033837001987 TraX protein; Region: TraX; cl05434 1033837001988 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1033837001989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033837001990 S-adenosylmethionine binding site [chemical binding]; other site 1033837001991 TRAM domain; Region: TRAM; cl01282 1033837001992 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033837001993 active site 1033837001994 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1033837001995 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837001996 active site 1033837001997 motif I; other site 1033837001998 motif II; other site 1033837001999 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837002000 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1033837002001 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033837002002 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1033837002003 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1033837002004 AAA ATPase domain; Region: AAA_16; pfam13191 1033837002005 Walker A motif; other site 1033837002006 ATP binding site [chemical binding]; other site 1033837002007 Walker B motif; other site 1033837002008 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1033837002009 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1033837002010 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1033837002011 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 1033837002012 putative active site [active] 1033837002013 catalytic triad [active] 1033837002014 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1033837002015 PA/protease or protease-like domain interface [polypeptide binding]; other site 1033837002016 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1033837002017 catalytic residues [active] 1033837002018 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 1033837002019 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1033837002020 TolA protein; Region: tolA_full; TIGR02794 1033837002021 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837002022 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1033837002023 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1033837002024 Protein of unknown function DUF262; Region: DUF262; pfam03235 1033837002025 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1033837002026 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1033837002027 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1033837002028 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1033837002029 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033837002030 ATP binding site [chemical binding]; other site 1033837002031 putative Mg++ binding site [ion binding]; other site 1033837002032 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1033837002033 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1033837002034 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1033837002035 Restriction endonuclease; Region: Mrr_cat; pfam04471 1033837002036 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1033837002037 Transposase IS200 like; Region: Y1_Tnp; cl00848 1033837002038 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1033837002039 active site turn [active] 1033837002040 phosphorylation site [posttranslational modification] 1033837002041 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 1033837002042 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1033837002043 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1033837002044 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1033837002045 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1033837002046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033837002047 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1033837002048 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1033837002049 Probable transposase; Region: OrfB_IS605; pfam01385 1033837002050 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1033837002051 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1033837002052 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1033837002053 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1033837002054 DNA binding residues [nucleotide binding] 1033837002055 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1033837002056 catalytic residues [active] 1033837002057 catalytic nucleophile [active] 1033837002058 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1033837002059 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1033837002060 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 1033837002061 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1033837002062 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1033837002063 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1033837002064 CAAX protease self-immunity; Region: Abi; pfam02517 1033837002065 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 1033837002066 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1033837002067 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033837002068 ABC transporter; Region: ABC_tran_2; pfam12848 1033837002069 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033837002070 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1033837002071 MutS domain III; Region: MutS_III; pfam05192 1033837002072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837002073 Walker A/P-loop; other site 1033837002074 ATP binding site [chemical binding]; other site 1033837002075 Q-loop/lid; other site 1033837002076 ABC transporter signature motif; other site 1033837002077 Walker B; other site 1033837002078 D-loop; other site 1033837002079 H-loop/switch region; other site 1033837002080 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1033837002081 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1033837002082 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1033837002083 recombination factor protein RarA; Reviewed; Region: PRK13342 1033837002084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033837002085 Walker A motif; other site 1033837002086 ATP binding site [chemical binding]; other site 1033837002087 Walker B motif; other site 1033837002088 arginine finger; other site 1033837002089 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1033837002090 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1033837002091 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1033837002092 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1033837002093 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1033837002094 ligand binding site [chemical binding]; other site 1033837002095 flexible hinge region; other site 1033837002096 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1033837002097 putative switch regulator; other site 1033837002098 non-specific DNA interactions [nucleotide binding]; other site 1033837002099 DNA binding site [nucleotide binding] 1033837002100 sequence specific DNA binding site [nucleotide binding]; other site 1033837002101 putative cAMP binding site [chemical binding]; other site 1033837002102 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1033837002103 dinuclear metal binding motif [ion binding]; other site 1033837002104 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1033837002105 metal-binding site [ion binding] 1033837002106 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1033837002107 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1033837002108 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1033837002109 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1033837002110 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1033837002111 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1033837002112 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1033837002113 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1033837002114 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1033837002115 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1033837002116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033837002117 homodimer interface [polypeptide binding]; other site 1033837002118 catalytic residue [active] 1033837002119 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 1033837002120 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1033837002121 Cupin domain; Region: Cupin_2; cl17218 1033837002122 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1033837002123 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1033837002124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033837002125 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1033837002126 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1033837002127 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1033837002128 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1033837002129 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033837002130 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1033837002131 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1033837002132 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1033837002133 putative Zn2+ binding site [ion binding]; other site 1033837002134 putative DNA binding site [nucleotide binding]; other site 1033837002135 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1033837002136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1033837002137 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033837002138 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1033837002139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033837002140 putative substrate translocation pore; other site 1033837002141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033837002142 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1033837002143 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 1033837002144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1033837002145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033837002146 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1033837002147 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033837002148 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1033837002149 Walker A/P-loop; other site 1033837002150 ATP binding site [chemical binding]; other site 1033837002151 Q-loop/lid; other site 1033837002152 ABC transporter signature motif; other site 1033837002153 Walker B; other site 1033837002154 D-loop; other site 1033837002155 H-loop/switch region; other site 1033837002156 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1033837002157 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033837002158 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1033837002159 Walker A/P-loop; other site 1033837002160 ATP binding site [chemical binding]; other site 1033837002161 Q-loop/lid; other site 1033837002162 ABC transporter signature motif; other site 1033837002163 Walker B; other site 1033837002164 D-loop; other site 1033837002165 H-loop/switch region; other site 1033837002166 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1033837002167 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1033837002168 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1033837002169 Walker A/P-loop; other site 1033837002170 ATP binding site [chemical binding]; other site 1033837002171 Q-loop/lid; other site 1033837002172 ABC transporter signature motif; other site 1033837002173 Walker B; other site 1033837002174 D-loop; other site 1033837002175 H-loop/switch region; other site 1033837002176 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1033837002177 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1033837002178 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1033837002179 dimer interface [polypeptide binding]; other site 1033837002180 catalytic triad [active] 1033837002181 peroxidatic and resolving cysteines [active] 1033837002182 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1033837002183 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1033837002184 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1033837002185 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1033837002186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1033837002187 Helix-turn-helix domain; Region: HTH_28; pfam13518 1033837002188 putative transposase OrfB; Reviewed; Region: PHA02517 1033837002189 HTH-like domain; Region: HTH_21; pfam13276 1033837002190 Integrase core domain; Region: rve; pfam00665 1033837002191 Integrase core domain; Region: rve_2; pfam13333 1033837002192 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1033837002193 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1033837002194 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1033837002195 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1033837002196 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1033837002197 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1033837002198 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1033837002199 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1033837002200 pyridoxal binding site [chemical binding]; other site 1033837002201 dimer interface [polypeptide binding]; other site 1033837002202 ATP binding site [chemical binding]; other site 1033837002203 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1033837002204 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1033837002205 active site 1033837002206 substrate binding site [chemical binding]; other site 1033837002207 trimer interface [polypeptide binding]; other site 1033837002208 CoA binding site [chemical binding]; other site 1033837002209 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1033837002210 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1033837002211 active site 1033837002212 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1033837002213 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1033837002214 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1033837002215 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1033837002216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033837002217 ATP binding site [chemical binding]; other site 1033837002218 putative Mg++ binding site [ion binding]; other site 1033837002219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033837002220 nucleotide binding region [chemical binding]; other site 1033837002221 ATP-binding site [chemical binding]; other site 1033837002222 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1033837002223 HRDC domain; Region: HRDC; pfam00570 1033837002224 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1033837002225 TrkA-N domain; Region: TrkA_N; pfam02254 1033837002226 TrkA-C domain; Region: TrkA_C; pfam02080 1033837002227 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1033837002228 Aluminium resistance protein; Region: Alum_res; pfam06838 1033837002229 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 1033837002230 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1033837002231 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1033837002232 catalytic residue [active] 1033837002233 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1033837002234 Amino acid permease; Region: AA_permease_2; pfam13520 1033837002235 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1033837002236 CrcB-like protein; Region: CRCB; cl09114 1033837002237 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1033837002238 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033837002239 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1033837002240 active site 1033837002241 catalytic residues [active] 1033837002242 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1033837002243 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033837002244 Walker A motif; other site 1033837002245 ATP binding site [chemical binding]; other site 1033837002246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1033837002247 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1033837002248 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1033837002249 active site 1033837002250 HslU subunit interaction site [polypeptide binding]; other site 1033837002251 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033837002252 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1033837002253 active site 1033837002254 DNA binding site [nucleotide binding] 1033837002255 Int/Topo IB signature motif; other site 1033837002256 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1033837002257 Glucose inhibited division protein A; Region: GIDA; pfam01134 1033837002258 DNA topoisomerase I; Validated; Region: PRK05582 1033837002259 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1033837002260 active site 1033837002261 interdomain interaction site; other site 1033837002262 putative metal-binding site [ion binding]; other site 1033837002263 nucleotide binding site [chemical binding]; other site 1033837002264 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1033837002265 domain I; other site 1033837002266 DNA binding groove [nucleotide binding] 1033837002267 phosphate binding site [ion binding]; other site 1033837002268 domain II; other site 1033837002269 domain III; other site 1033837002270 nucleotide binding site [chemical binding]; other site 1033837002271 catalytic site [active] 1033837002272 domain IV; other site 1033837002273 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1033837002274 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1033837002275 DNA protecting protein DprA; Region: dprA; TIGR00732 1033837002276 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1033837002277 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1033837002278 RNA/DNA hybrid binding site [nucleotide binding]; other site 1033837002279 active site 1033837002280 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 1033837002281 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1033837002282 GTP/Mg2+ binding site [chemical binding]; other site 1033837002283 G4 box; other site 1033837002284 G5 box; other site 1033837002285 G1 box; other site 1033837002286 Switch I region; other site 1033837002287 G2 box; other site 1033837002288 G3 box; other site 1033837002289 Switch II region; other site 1033837002290 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1033837002291 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1033837002292 hypothetical protein; Provisional; Region: PRK13672 1033837002293 EDD domain protein, DegV family; Region: DegV; TIGR00762 1033837002294 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1033837002295 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1033837002296 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1033837002297 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1033837002298 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1033837002299 active site 1033837002300 NTP binding site [chemical binding]; other site 1033837002301 metal binding triad [ion binding]; metal-binding site 1033837002302 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1033837002303 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1033837002304 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1033837002305 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1033837002306 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1033837002307 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1033837002308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1033837002309 binding surface 1033837002310 TPR motif; other site 1033837002311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1033837002312 binding surface 1033837002313 TPR motif; other site 1033837002314 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1033837002315 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1033837002316 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1033837002317 IHF dimer interface [polypeptide binding]; other site 1033837002318 IHF - DNA interface [nucleotide binding]; other site 1033837002319 GTP-binding protein Der; Reviewed; Region: PRK00093 1033837002320 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1033837002321 G1 box; other site 1033837002322 GTP/Mg2+ binding site [chemical binding]; other site 1033837002323 Switch I region; other site 1033837002324 G2 box; other site 1033837002325 Switch II region; other site 1033837002326 G3 box; other site 1033837002327 G4 box; other site 1033837002328 G5 box; other site 1033837002329 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1033837002330 G1 box; other site 1033837002331 GTP/Mg2+ binding site [chemical binding]; other site 1033837002332 Switch I region; other site 1033837002333 G2 box; other site 1033837002334 G3 box; other site 1033837002335 Switch II region; other site 1033837002336 G4 box; other site 1033837002337 G5 box; other site 1033837002338 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1033837002339 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1033837002340 RNA binding site [nucleotide binding]; other site 1033837002341 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1033837002342 RNA binding site [nucleotide binding]; other site 1033837002343 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1033837002344 RNA binding site [nucleotide binding]; other site 1033837002345 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1033837002346 RNA binding site [nucleotide binding]; other site 1033837002347 cytidylate kinase; Provisional; Region: cmk; PRK00023 1033837002348 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1033837002349 CMP-binding site; other site 1033837002350 The sites determining sugar specificity; other site 1033837002351 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1033837002352 Predicted membrane protein [Function unknown]; Region: COG3601 1033837002353 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1033837002354 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1033837002355 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1033837002356 RNA binding surface [nucleotide binding]; other site 1033837002357 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1033837002358 active site 1033837002359 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1033837002360 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1033837002361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1033837002362 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033837002363 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1033837002364 active site 1033837002365 DNA binding site [nucleotide binding] 1033837002366 Int/Topo IB signature motif; other site 1033837002367 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1033837002368 S1 domain; Region: S1_2; pfam13509 1033837002369 pyruvate kinase; Provisional; Region: PRK06354 1033837002370 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1033837002371 domain interfaces; other site 1033837002372 active site 1033837002373 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1033837002374 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1033837002375 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1033837002376 active site 1033837002377 ADP/pyrophosphate binding site [chemical binding]; other site 1033837002378 dimerization interface [polypeptide binding]; other site 1033837002379 allosteric effector site; other site 1033837002380 fructose-1,6-bisphosphate binding site; other site 1033837002381 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1033837002382 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1033837002383 active site 1033837002384 PHP Thumb interface [polypeptide binding]; other site 1033837002385 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1033837002386 generic binding surface I; other site 1033837002387 generic binding surface II; other site 1033837002388 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1033837002389 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1033837002390 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1033837002391 active site 1033837002392 metal binding site [ion binding]; metal-binding site 1033837002393 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1033837002394 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1033837002395 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1033837002396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1033837002397 NAD(P) binding site [chemical binding]; other site 1033837002398 active site 1033837002399 ribonuclease Z; Region: RNase_Z; TIGR02651 1033837002400 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1033837002401 GTP1/OBG; Region: GTP1_OBG; pfam01018 1033837002402 Obg GTPase; Region: Obg; cd01898 1033837002403 G1 box; other site 1033837002404 GTP/Mg2+ binding site [chemical binding]; other site 1033837002405 Switch I region; other site 1033837002406 G2 box; other site 1033837002407 G3 box; other site 1033837002408 Switch II region; other site 1033837002409 G4 box; other site 1033837002410 G5 box; other site 1033837002411 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1033837002412 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1033837002413 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1033837002414 GIY-YIG motif/motif A; other site 1033837002415 active site 1033837002416 catalytic site [active] 1033837002417 putative DNA binding site [nucleotide binding]; other site 1033837002418 metal binding site [ion binding]; metal-binding site 1033837002419 UvrB/uvrC motif; Region: UVR; pfam02151 1033837002420 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1033837002421 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1033837002422 DNA binding site [nucleotide binding] 1033837002423 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1033837002424 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1033837002425 amino acid transporter; Region: 2A0306; TIGR00909 1033837002426 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1033837002427 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1033837002428 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1033837002429 NAD binding site [chemical binding]; other site 1033837002430 sugar phosphate phosphatase; Provisional; Region: PRK10513 1033837002431 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837002432 active site 1033837002433 motif I; other site 1033837002434 motif II; other site 1033837002435 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837002436 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1033837002437 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1033837002438 active site 1033837002439 catalytic tetrad [active] 1033837002440 Flavoprotein; Region: Flavoprotein; pfam02441 1033837002441 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1033837002442 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1033837002443 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1033837002444 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1033837002445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033837002446 homodimer interface [polypeptide binding]; other site 1033837002447 catalytic residue [active] 1033837002448 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1033837002449 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1033837002450 dimer interface [polypeptide binding]; other site 1033837002451 anticodon binding site; other site 1033837002452 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1033837002453 homodimer interface [polypeptide binding]; other site 1033837002454 motif 1; other site 1033837002455 active site 1033837002456 motif 2; other site 1033837002457 GAD domain; Region: GAD; pfam02938 1033837002458 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1033837002459 active site 1033837002460 motif 3; other site 1033837002461 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1033837002462 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1033837002463 dimer interface [polypeptide binding]; other site 1033837002464 motif 1; other site 1033837002465 active site 1033837002466 motif 2; other site 1033837002467 motif 3; other site 1033837002468 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1033837002469 anticodon binding site; other site 1033837002470 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1033837002471 putative active site [active] 1033837002472 dimerization interface [polypeptide binding]; other site 1033837002473 putative tRNAtyr binding site [nucleotide binding]; other site 1033837002474 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1033837002475 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1033837002476 Zn2+ binding site [ion binding]; other site 1033837002477 Mg2+ binding site [ion binding]; other site 1033837002478 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1033837002479 synthetase active site [active] 1033837002480 NTP binding site [chemical binding]; other site 1033837002481 metal binding site [ion binding]; metal-binding site 1033837002482 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1033837002483 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1033837002484 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1033837002485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033837002486 S-adenosylmethionine binding site [chemical binding]; other site 1033837002487 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1033837002488 putative deacylase active site [active] 1033837002489 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 1033837002490 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1033837002491 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1033837002492 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1033837002493 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1033837002494 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1033837002495 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 1033837002496 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1033837002497 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1033837002498 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1033837002499 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1033837002500 citrate lyase subunit gamma; Provisional; Region: PRK13253 1033837002501 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1033837002502 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1033837002503 active site 1033837002504 nucleotide binding site [chemical binding]; other site 1033837002505 HIGH motif; other site 1033837002506 KMSKS motif; other site 1033837002507 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1033837002508 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1033837002509 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1033837002510 transmembrane helices; other site 1033837002511 hypothetical protein; Validated; Region: PRK06201 1033837002512 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1033837002513 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1033837002514 trimer interface [polypeptide binding]; other site 1033837002515 active site 1033837002516 G bulge; other site 1033837002517 MucBP domain; Region: MucBP; pfam06458 1033837002518 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1033837002519 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1033837002520 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1033837002521 NAD binding site [chemical binding]; other site 1033837002522 dimer interface [polypeptide binding]; other site 1033837002523 substrate binding site [chemical binding]; other site 1033837002524 L-aspartate oxidase; Provisional; Region: PRK06175 1033837002525 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1033837002526 L-aspartate oxidase; Provisional; Region: PRK06175 1033837002527 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1033837002528 Class II fumarases; Region: Fumarase_classII; cd01362 1033837002529 active site 1033837002530 tetramer interface [polypeptide binding]; other site 1033837002531 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1033837002532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033837002533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033837002534 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1033837002535 putative substrate translocation pore; other site 1033837002536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837002537 dimer interface [polypeptide binding]; other site 1033837002538 conserved gate region; other site 1033837002539 ABC-ATPase subunit interface; other site 1033837002540 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1033837002541 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1033837002542 Walker A/P-loop; other site 1033837002543 ATP binding site [chemical binding]; other site 1033837002544 Q-loop/lid; other site 1033837002545 ABC transporter signature motif; other site 1033837002546 Walker B; other site 1033837002547 D-loop; other site 1033837002548 H-loop/switch region; other site 1033837002549 NIL domain; Region: NIL; pfam09383 1033837002550 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1033837002551 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1033837002552 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1033837002553 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1033837002554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837002555 motif I; other site 1033837002556 motif II; other site 1033837002557 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1033837002558 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1033837002559 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1033837002560 folate binding site [chemical binding]; other site 1033837002561 NADP+ binding site [chemical binding]; other site 1033837002562 thymidylate synthase; Region: thym_sym; TIGR03284 1033837002563 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1033837002564 dimerization interface [polypeptide binding]; other site 1033837002565 active site 1033837002566 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1033837002567 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1033837002568 active site 1033837002569 EDD domain protein, DegV family; Region: DegV; TIGR00762 1033837002570 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1033837002571 enolase; Provisional; Region: eno; PRK00077 1033837002572 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1033837002573 dimer interface [polypeptide binding]; other site 1033837002574 metal binding site [ion binding]; metal-binding site 1033837002575 substrate binding pocket [chemical binding]; other site 1033837002576 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1033837002577 FMN binding site [chemical binding]; other site 1033837002578 dimer interface [polypeptide binding]; other site 1033837002579 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1033837002580 beta-galactosidase; Region: BGL; TIGR03356 1033837002581 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1033837002582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033837002583 DNA-binding site [nucleotide binding]; DNA binding site 1033837002584 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1033837002585 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1033837002586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1033837002587 Integrase core domain; Region: rve; pfam00665 1033837002588 Integrase core domain; Region: rve_2; pfam13333 1033837002589 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1033837002590 nudix motif; other site 1033837002591 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1033837002592 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1033837002593 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1033837002594 active site 1033837002595 Isochorismatase family; Region: Isochorismatase; pfam00857 1033837002596 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1033837002597 catalytic triad [active] 1033837002598 conserved cis-peptide bond; other site 1033837002599 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1033837002600 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1033837002601 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 1033837002602 catalytic Zn binding site [ion binding]; other site 1033837002603 NAD binding site [chemical binding]; other site 1033837002604 structural Zn binding site [ion binding]; other site 1033837002605 Cupin domain; Region: Cupin_2; cl17218 1033837002606 Helix-turn-helix domain; Region: HTH_18; pfam12833 1033837002607 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033837002608 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1033837002609 active site 1033837002610 dimerization interface [polypeptide binding]; other site 1033837002611 FMN-binding domain; Region: FMN_bind; cl01081 1033837002612 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 1033837002613 nucleophilic elbow; other site 1033837002614 catalytic triad; other site 1033837002615 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 1033837002616 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1033837002617 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1033837002618 nudix motif; other site 1033837002619 Beta-lactamase; Region: Beta-lactamase; pfam00144 1033837002620 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1033837002621 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1033837002622 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1033837002623 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1033837002624 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1033837002625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1033837002626 homodimer interface [polypeptide binding]; other site 1033837002627 catalytic residue [active] 1033837002628 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1033837002629 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1033837002630 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1033837002631 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1033837002632 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1033837002633 dimer interface [polypeptide binding]; other site 1033837002634 active site 1033837002635 catalytic residue [active] 1033837002636 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1033837002637 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1033837002638 metal binding site [ion binding]; metal-binding site 1033837002639 putative dimer interface [polypeptide binding]; other site 1033837002640 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1033837002641 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1033837002642 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1033837002643 putative trimer interface [polypeptide binding]; other site 1033837002644 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1033837002645 putative CoA binding site [chemical binding]; other site 1033837002646 putative trimer interface [polypeptide binding]; other site 1033837002647 putative CoA binding site [chemical binding]; other site 1033837002648 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1033837002649 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1033837002650 active site 1033837002651 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1033837002652 substrate binding site [chemical binding]; other site 1033837002653 catalytic residues [active] 1033837002654 dimer interface [polypeptide binding]; other site 1033837002655 aspartate kinase; Reviewed; Region: PRK09034 1033837002656 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1033837002657 putative catalytic residues [active] 1033837002658 putative nucleotide binding site [chemical binding]; other site 1033837002659 putative aspartate binding site [chemical binding]; other site 1033837002660 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1033837002661 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1033837002662 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1033837002663 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1033837002664 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1033837002665 inner membrane transporter YjeM; Provisional; Region: PRK15238 1033837002666 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1033837002667 G1 box; other site 1033837002668 GTP/Mg2+ binding site [chemical binding]; other site 1033837002669 Switch I region; other site 1033837002670 G2 box; other site 1033837002671 G3 box; other site 1033837002672 Switch II region; other site 1033837002673 G4 box; other site 1033837002674 G5 box; other site 1033837002675 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1033837002676 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1033837002677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033837002678 Walker A motif; other site 1033837002679 ATP binding site [chemical binding]; other site 1033837002680 Walker B motif; other site 1033837002681 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1033837002682 trigger factor; Provisional; Region: tig; PRK01490 1033837002683 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1033837002684 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1033837002685 elongation factor Tu; Reviewed; Region: PRK00049 1033837002686 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1033837002687 G1 box; other site 1033837002688 GEF interaction site [polypeptide binding]; other site 1033837002689 GTP/Mg2+ binding site [chemical binding]; other site 1033837002690 Switch I region; other site 1033837002691 G2 box; other site 1033837002692 G3 box; other site 1033837002693 Switch II region; other site 1033837002694 G4 box; other site 1033837002695 G5 box; other site 1033837002696 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1033837002697 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1033837002698 Antibiotic Binding Site [chemical binding]; other site 1033837002699 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1033837002700 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1033837002701 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1033837002702 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1033837002703 16S/18S rRNA binding site [nucleotide binding]; other site 1033837002704 S13e-L30e interaction site [polypeptide binding]; other site 1033837002705 25S rRNA binding site [nucleotide binding]; other site 1033837002706 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1033837002707 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1033837002708 DNA polymerase III, delta subunit; Region: holA; TIGR01128 1033837002709 SLBB domain; Region: SLBB; pfam10531 1033837002710 comEA protein; Region: comE; TIGR01259 1033837002711 Helix-hairpin-helix motif; Region: HHH; pfam00633 1033837002712 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1033837002713 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1033837002714 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1033837002715 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1033837002716 active site 1033837002717 (T/H)XGH motif; other site 1033837002718 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1033837002719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033837002720 S-adenosylmethionine binding site [chemical binding]; other site 1033837002721 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 1033837002722 cell division protein FtsW; Region: ftsW; TIGR02614 1033837002723 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1033837002724 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1033837002725 G1 box; other site 1033837002726 putative GEF interaction site [polypeptide binding]; other site 1033837002727 GTP/Mg2+ binding site [chemical binding]; other site 1033837002728 Switch I region; other site 1033837002729 G2 box; other site 1033837002730 G3 box; other site 1033837002731 Switch II region; other site 1033837002732 G4 box; other site 1033837002733 G5 box; other site 1033837002734 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1033837002735 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1033837002736 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1033837002737 active site 1033837002738 catalytic residues [active] 1033837002739 metal binding site [ion binding]; metal-binding site 1033837002740 hypothetical protein; Provisional; Region: PRK13667 1033837002741 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1033837002742 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1033837002743 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1033837002744 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1033837002745 AAA domain; Region: AAA_30; pfam13604 1033837002746 Family description; Region: UvrD_C_2; pfam13538 1033837002747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1033837002748 binding surface 1033837002749 TPR motif; other site 1033837002750 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1033837002751 catalytic core [active] 1033837002752 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1033837002753 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1033837002754 Putative amino acid metabolism; Region: DUF1831; pfam08866 1033837002755 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1033837002756 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1033837002757 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1033837002758 catalytic residue [active] 1033837002759 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1033837002760 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1033837002761 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1033837002762 dimer interface [polypeptide binding]; other site 1033837002763 ADP-ribose binding site [chemical binding]; other site 1033837002764 active site 1033837002765 nudix motif; other site 1033837002766 metal binding site [ion binding]; metal-binding site 1033837002767 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1033837002768 DNA-binding site [nucleotide binding]; DNA binding site 1033837002769 RNA-binding motif; other site 1033837002770 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1033837002771 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1033837002772 active site 1033837002773 HIGH motif; other site 1033837002774 nucleotide binding site [chemical binding]; other site 1033837002775 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1033837002776 active site 1033837002777 KMSKS motif; other site 1033837002778 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1033837002779 tRNA binding surface [nucleotide binding]; other site 1033837002780 anticodon binding site; other site 1033837002781 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1033837002782 DivIVA protein; Region: DivIVA; pfam05103 1033837002783 DivIVA domain; Region: DivI1A_domain; TIGR03544 1033837002784 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1033837002785 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1033837002786 RNA binding surface [nucleotide binding]; other site 1033837002787 YGGT family; Region: YGGT; cl00508 1033837002788 Protein of unknown function (DUF552); Region: DUF552; cl00775 1033837002789 cell division protein FtsZ; Validated; Region: PRK09330 1033837002790 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1033837002791 nucleotide binding site [chemical binding]; other site 1033837002792 SulA interaction site; other site 1033837002793 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1033837002794 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1033837002795 nucleotide binding site [chemical binding]; other site 1033837002796 Cell division protein FtsA; Region: FtsA; cl17206 1033837002797 Cell division protein FtsA; Region: FtsA; pfam14450 1033837002798 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1033837002799 Cell division protein FtsQ; Region: FtsQ; pfam03799 1033837002800 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1033837002801 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1033837002802 active site 1033837002803 homodimer interface [polypeptide binding]; other site 1033837002804 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1033837002805 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1033837002806 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1033837002807 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1033837002808 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1033837002809 Mg++ binding site [ion binding]; other site 1033837002810 putative catalytic motif [active] 1033837002811 putative substrate binding site [chemical binding]; other site 1033837002812 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1033837002813 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1033837002814 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1033837002815 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1033837002816 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1033837002817 Cell division protein FtsL; Region: FtsL; cl11433 1033837002818 MraW methylase family; Region: Methyltransf_5; pfam01795 1033837002819 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1033837002820 cell division protein MraZ; Reviewed; Region: PRK00326 1033837002821 MraZ protein; Region: MraZ; pfam02381 1033837002822 MraZ protein; Region: MraZ; pfam02381 1033837002823 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 1033837002824 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 1033837002825 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1033837002826 rod shape-determining protein MreC; Provisional; Region: PRK13922 1033837002827 rod shape-determining protein MreC; Region: MreC; pfam04085 1033837002828 rod shape-determining protein MreB; Provisional; Region: PRK13927 1033837002829 MreB and similar proteins; Region: MreB_like; cd10225 1033837002830 nucleotide binding site [chemical binding]; other site 1033837002831 Mg binding site [ion binding]; other site 1033837002832 putative protofilament interaction site [polypeptide binding]; other site 1033837002833 RodZ interaction site [polypeptide binding]; other site 1033837002834 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1033837002835 MPN+ (JAMM) motif; other site 1033837002836 Zinc-binding site [ion binding]; other site 1033837002837 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1033837002838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837002839 motif II; other site 1033837002840 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1033837002841 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1033837002842 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1033837002843 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1033837002844 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1033837002845 active site 1033837002846 HIGH motif; other site 1033837002847 nucleotide binding site [chemical binding]; other site 1033837002848 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1033837002849 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1033837002850 active site 1033837002851 KMSKS motif; other site 1033837002852 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1033837002853 tRNA binding surface [nucleotide binding]; other site 1033837002854 anticodon binding site; other site 1033837002855 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1033837002856 Toxin ToxN, type III toxin-antitoxin system; Region: ToxN_toxin; pfam13958 1033837002857 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cl00559 1033837002858 tetramer interfaces [polypeptide binding]; other site 1033837002859 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1033837002860 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1033837002861 Ligand binding site; other site 1033837002862 Putative Catalytic site; other site 1033837002863 DXD motif; other site 1033837002864 Predicted membrane protein [Function unknown]; Region: COG2246 1033837002865 GtrA-like protein; Region: GtrA; pfam04138 1033837002866 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1033837002867 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 1033837002868 active site 1033837002869 catalytic site [active] 1033837002870 metal binding site [ion binding]; metal-binding site 1033837002871 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1033837002872 MULE transposase domain; Region: MULE; pfam10551 1033837002873 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 1033837002874 FMN-binding domain; Region: FMN_bind; pfam04205 1033837002875 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1033837002876 L-aspartate oxidase; Provisional; Region: PRK06175 1033837002877 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1033837002878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1033837002879 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1033837002880 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1033837002881 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837002882 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1033837002883 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033837002884 non-specific DNA binding site [nucleotide binding]; other site 1033837002885 salt bridge; other site 1033837002886 sequence-specific DNA binding site [nucleotide binding]; other site 1033837002887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1033837002888 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1033837002889 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1033837002890 RNA binding surface [nucleotide binding]; other site 1033837002891 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1033837002892 active site 1033837002893 uracil binding [chemical binding]; other site 1033837002894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033837002895 sequence-specific DNA binding site [nucleotide binding]; other site 1033837002896 salt bridge; other site 1033837002897 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1033837002898 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1033837002899 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1033837002900 Ligand Binding Site [chemical binding]; other site 1033837002901 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1033837002902 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1033837002903 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1033837002904 catalytic residue [active] 1033837002905 septation ring formation regulator EzrA; Provisional; Region: PRK04778 1033837002906 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1033837002907 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1033837002908 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1033837002909 RNA binding surface [nucleotide binding]; other site 1033837002910 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1033837002911 recombination factor protein RarA; Reviewed; Region: PRK13342 1033837002912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033837002913 Walker A motif; other site 1033837002914 ATP binding site [chemical binding]; other site 1033837002915 Walker B motif; other site 1033837002916 arginine finger; other site 1033837002917 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1033837002918 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1033837002919 Ligand Binding Site [chemical binding]; other site 1033837002920 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 1033837002921 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1033837002922 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1033837002923 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1033837002924 Probable transposase; Region: OrfB_IS605; pfam01385 1033837002925 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1033837002926 Rib/alpha-like repeat; Region: Rib; cl07159 1033837002927 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1033837002928 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1033837002929 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1033837002930 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1033837002931 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1033837002932 Double zinc ribbon; Region: DZR; pfam12773 1033837002933 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1033837002934 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1033837002935 rod shape-determining protein MreB; Provisional; Region: PRK13930 1033837002936 MreB and similar proteins; Region: MreB_like; cd10225 1033837002937 nucleotide binding site [chemical binding]; other site 1033837002938 Mg binding site [ion binding]; other site 1033837002939 putative protofilament interaction site [polypeptide binding]; other site 1033837002940 RodZ interaction site [polypeptide binding]; other site 1033837002941 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1033837002942 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1033837002943 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1033837002944 gamma subunit interface [polypeptide binding]; other site 1033837002945 epsilon subunit interface [polypeptide binding]; other site 1033837002946 LBP interface [polypeptide binding]; other site 1033837002947 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1033837002948 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1033837002949 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1033837002950 alpha subunit interaction interface [polypeptide binding]; other site 1033837002951 Walker A motif; other site 1033837002952 ATP binding site [chemical binding]; other site 1033837002953 Walker B motif; other site 1033837002954 inhibitor binding site; inhibition site 1033837002955 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1033837002956 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1033837002957 core domain interface [polypeptide binding]; other site 1033837002958 delta subunit interface [polypeptide binding]; other site 1033837002959 epsilon subunit interface [polypeptide binding]; other site 1033837002960 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1033837002961 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1033837002962 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1033837002963 beta subunit interaction interface [polypeptide binding]; other site 1033837002964 Walker A motif; other site 1033837002965 ATP binding site [chemical binding]; other site 1033837002966 Walker B motif; other site 1033837002967 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1033837002968 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1033837002969 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1033837002970 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1033837002971 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1033837002972 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1033837002973 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1033837002974 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1033837002975 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033837002976 active site 1033837002977 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1033837002978 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1033837002979 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1033837002980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033837002981 S-adenosylmethionine binding site [chemical binding]; other site 1033837002982 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1033837002983 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1033837002984 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1033837002985 RF-1 domain; Region: RF-1; pfam00472 1033837002986 thymidine kinase; Provisional; Region: PRK04296 1033837002987 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1033837002988 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1033837002989 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1033837002990 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1033837002991 Beta-lactamase; Region: Beta-lactamase; pfam00144 1033837002992 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1033837002993 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1033837002994 active site 1033837002995 dimer interface [polypeptide binding]; other site 1033837002996 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1033837002997 dimer interface [polypeptide binding]; other site 1033837002998 active site 1033837002999 VanZ like family; Region: VanZ; pfam04892 1033837003000 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1033837003001 Sulfatase; Region: Sulfatase; pfam00884 1033837003002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1033837003003 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1033837003004 dimerization interface [polypeptide binding]; other site 1033837003005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033837003006 dimer interface [polypeptide binding]; other site 1033837003007 phosphorylation site [posttranslational modification] 1033837003008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033837003009 ATP binding site [chemical binding]; other site 1033837003010 Mg2+ binding site [ion binding]; other site 1033837003011 G-X-G motif; other site 1033837003012 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1033837003013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033837003014 active site 1033837003015 phosphorylation site [posttranslational modification] 1033837003016 intermolecular recognition site; other site 1033837003017 dimerization interface [polypeptide binding]; other site 1033837003018 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033837003019 DNA binding site [nucleotide binding] 1033837003020 SdpI/YhfL protein family; Region: SdpI; pfam13630 1033837003021 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1033837003022 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1033837003023 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1033837003024 propionate/acetate kinase; Provisional; Region: PRK12379 1033837003025 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1033837003026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033837003027 S-adenosylmethionine binding site [chemical binding]; other site 1033837003028 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1033837003029 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1033837003030 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1033837003031 Type II/IV secretion system protein; Region: T2SE; pfam00437 1033837003032 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1033837003033 Walker A motif; other site 1033837003034 ATP binding site [chemical binding]; other site 1033837003035 Walker B motif; other site 1033837003036 hypothetical protein; Validated; Region: PRK00110 1033837003037 Predicted integral membrane protein [Function unknown]; Region: COG5652 1033837003038 Amino acid permease; Region: AA_permease_2; pfam13520 1033837003039 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1033837003040 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1033837003041 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1033837003042 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1033837003043 active site turn [active] 1033837003044 phosphorylation site [posttranslational modification] 1033837003045 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1033837003046 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1033837003047 HPr interaction site; other site 1033837003048 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1033837003049 active site 1033837003050 phosphorylation site [posttranslational modification] 1033837003051 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1033837003052 CAT RNA binding domain; Region: CAT_RBD; smart01061 1033837003053 PRD domain; Region: PRD; pfam00874 1033837003054 PRD domain; Region: PRD; pfam00874 1033837003055 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1033837003056 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1033837003057 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1033837003058 active site 1033837003059 clostripain; Region: clostrip; TIGR02806 1033837003060 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1033837003061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837003062 active site 1033837003063 motif I; other site 1033837003064 motif II; other site 1033837003065 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1033837003066 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1033837003067 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837003068 active site 1033837003069 motif I; other site 1033837003070 motif II; other site 1033837003071 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1033837003072 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1033837003073 active site 1033837003074 substrate binding site [chemical binding]; other site 1033837003075 metal binding site [ion binding]; metal-binding site 1033837003076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1033837003077 YbbR-like protein; Region: YbbR; pfam07949 1033837003078 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1033837003079 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1033837003080 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1033837003081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837003082 dimer interface [polypeptide binding]; other site 1033837003083 conserved gate region; other site 1033837003084 putative PBP binding loops; other site 1033837003085 ABC-ATPase subunit interface; other site 1033837003086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837003087 dimer interface [polypeptide binding]; other site 1033837003088 conserved gate region; other site 1033837003089 putative PBP binding loops; other site 1033837003090 ABC-ATPase subunit interface; other site 1033837003091 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1033837003092 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1033837003093 Walker A/P-loop; other site 1033837003094 ATP binding site [chemical binding]; other site 1033837003095 Q-loop/lid; other site 1033837003096 ABC transporter signature motif; other site 1033837003097 Walker B; other site 1033837003098 D-loop; other site 1033837003099 H-loop/switch region; other site 1033837003100 TOBE domain; Region: TOBE_2; pfam08402 1033837003101 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1033837003102 FAD binding domain; Region: FAD_binding_4; pfam01565 1033837003103 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1033837003104 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1033837003105 active site 1033837003106 catalytic site [active] 1033837003107 substrate binding site [chemical binding]; other site 1033837003108 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1033837003109 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1033837003110 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1033837003111 ligand binding site [chemical binding]; other site 1033837003112 active site 1033837003113 UGI interface [polypeptide binding]; other site 1033837003114 catalytic site [active] 1033837003115 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1033837003116 triosephosphate isomerase; Provisional; Region: PRK14567 1033837003117 substrate binding site [chemical binding]; other site 1033837003118 dimer interface [polypeptide binding]; other site 1033837003119 catalytic triad [active] 1033837003120 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1033837003121 Phosphoglycerate kinase; Region: PGK; pfam00162 1033837003122 substrate binding site [chemical binding]; other site 1033837003123 hinge regions; other site 1033837003124 ADP binding site [chemical binding]; other site 1033837003125 catalytic site [active] 1033837003126 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1033837003127 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1033837003128 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1033837003129 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1033837003130 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1033837003131 SH3-like domain; Region: SH3_8; pfam13457 1033837003132 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1033837003133 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1033837003134 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1033837003135 oligomer interface [polypeptide binding]; other site 1033837003136 active site residues [active] 1033837003137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1033837003138 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1033837003139 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1033837003140 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1033837003141 putative substrate binding pocket [chemical binding]; other site 1033837003142 dimer interface [polypeptide binding]; other site 1033837003143 phosphate binding site [ion binding]; other site 1033837003144 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1033837003145 AAA domain; Region: AAA_18; pfam13238 1033837003146 excinuclease ABC subunit B; Provisional; Region: PRK05298 1033837003147 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 1033837003148 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033837003149 ATP-binding site [chemical binding]; other site 1033837003150 ATP binding site [chemical binding]; other site 1033837003151 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033837003152 nucleotide binding region [chemical binding]; other site 1033837003153 ATP-binding site [chemical binding]; other site 1033837003154 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1033837003155 UvrB/uvrC motif; Region: UVR; pfam02151 1033837003156 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1033837003157 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1033837003158 active site 1033837003159 substrate binding site [chemical binding]; other site 1033837003160 metal binding site [ion binding]; metal-binding site 1033837003161 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1033837003162 active site 1033837003163 homodimer interface [polypeptide binding]; other site 1033837003164 catalytic site [active] 1033837003165 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1033837003166 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1033837003167 active site pocket [active] 1033837003168 glycogen synthase; Provisional; Region: glgA; PRK00654 1033837003169 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1033837003170 ADP-binding pocket [chemical binding]; other site 1033837003171 homodimer interface [polypeptide binding]; other site 1033837003172 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1033837003173 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1033837003174 active site 1033837003175 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1033837003176 dimer interface [polypeptide binding]; other site 1033837003177 N-terminal domain interface [polypeptide binding]; other site 1033837003178 sulfate 1 binding site; other site 1033837003179 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1033837003180 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1033837003181 ligand binding site; other site 1033837003182 oligomer interface; other site 1033837003183 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1033837003184 dimer interface [polypeptide binding]; other site 1033837003185 N-terminal domain interface [polypeptide binding]; other site 1033837003186 sulfate 1 binding site; other site 1033837003187 glycogen branching enzyme; Provisional; Region: PRK12313 1033837003188 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1033837003189 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1033837003190 active site 1033837003191 catalytic site [active] 1033837003192 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1033837003193 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1033837003194 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1033837003195 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1033837003196 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1033837003197 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033837003198 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1033837003199 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1033837003200 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1033837003201 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1033837003202 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1033837003203 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1033837003204 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1033837003205 Hpr binding site; other site 1033837003206 active site 1033837003207 homohexamer subunit interaction site [polypeptide binding]; other site 1033837003208 peptide chain release factor 2; Provisional; Region: PRK05589 1033837003209 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1033837003210 RF-1 domain; Region: RF-1; pfam00472 1033837003211 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 1033837003212 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1033837003213 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033837003214 nucleotide binding region [chemical binding]; other site 1033837003215 ATP-binding site [chemical binding]; other site 1033837003216 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1033837003217 30S subunit binding site; other site 1033837003218 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1033837003219 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033837003220 active site 1033837003221 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1033837003222 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033837003223 ATP binding site [chemical binding]; other site 1033837003224 putative Mg++ binding site [ion binding]; other site 1033837003225 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033837003226 nucleotide binding region [chemical binding]; other site 1033837003227 ATP-binding site [chemical binding]; other site 1033837003228 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1033837003229 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1033837003230 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1033837003231 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1033837003232 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1033837003233 Mg++ binding site [ion binding]; other site 1033837003234 putative catalytic motif [active] 1033837003235 substrate binding site [chemical binding]; other site 1033837003236 phosphodiesterase; Provisional; Region: PRK12704 1033837003237 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1033837003238 Zn2+ binding site [ion binding]; other site 1033837003239 Mg2+ binding site [ion binding]; other site 1033837003240 recombinase A; Provisional; Region: recA; PRK09354 1033837003241 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1033837003242 hexamer interface [polypeptide binding]; other site 1033837003243 Walker A motif; other site 1033837003244 ATP binding site [chemical binding]; other site 1033837003245 Walker B motif; other site 1033837003246 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1033837003247 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1033837003248 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033837003249 non-specific DNA binding site [nucleotide binding]; other site 1033837003250 salt bridge; other site 1033837003251 sequence-specific DNA binding site [nucleotide binding]; other site 1033837003252 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1033837003253 classical (c) SDRs; Region: SDR_c; cd05233 1033837003254 NAD(P) binding site [chemical binding]; other site 1033837003255 active site 1033837003256 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1033837003257 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1033837003258 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1033837003259 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1033837003260 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1033837003261 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1033837003262 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1033837003263 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1033837003264 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1033837003265 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 1033837003266 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1033837003267 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1033837003268 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1033837003269 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 1033837003270 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1033837003271 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1033837003272 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1033837003273 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1033837003274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837003275 motif II; other site 1033837003276 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1033837003277 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1033837003278 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1033837003279 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1033837003280 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1033837003281 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1033837003282 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1033837003283 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1033837003284 synthetase active site [active] 1033837003285 NTP binding site [chemical binding]; other site 1033837003286 metal binding site [ion binding]; metal-binding site 1033837003287 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1033837003288 putative active site [active] 1033837003289 putative metal binding residues [ion binding]; other site 1033837003290 signature motif; other site 1033837003291 putative triphosphate binding site [ion binding]; other site 1033837003292 Thioredoxin; Region: Thioredoxin_5; pfam13743 1033837003293 Competence protein CoiA-like family; Region: CoiA; cl11541 1033837003294 adaptor protein; Provisional; Region: PRK02315 1033837003295 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1033837003296 ArsC family; Region: ArsC; pfam03960 1033837003297 putative catalytic residues [active] 1033837003298 thiol/disulfide switch; other site 1033837003299 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1033837003300 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1033837003301 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1033837003302 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1033837003303 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1033837003304 dimerization domain swap beta strand [polypeptide binding]; other site 1033837003305 regulatory protein interface [polypeptide binding]; other site 1033837003306 active site 1033837003307 regulatory phosphorylation site [posttranslational modification]; other site 1033837003308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033837003309 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1033837003310 Walker A motif; other site 1033837003311 ATP binding site [chemical binding]; other site 1033837003312 Walker B motif; other site 1033837003313 arginine finger; other site 1033837003314 UvrB/uvrC motif; Region: UVR; pfam02151 1033837003315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033837003316 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1033837003317 Walker A motif; other site 1033837003318 ATP binding site [chemical binding]; other site 1033837003319 Walker B motif; other site 1033837003320 arginine finger; other site 1033837003321 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1033837003322 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 1033837003323 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1033837003324 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1033837003325 G1 box; other site 1033837003326 putative GEF interaction site [polypeptide binding]; other site 1033837003327 GTP/Mg2+ binding site [chemical binding]; other site 1033837003328 Switch I region; other site 1033837003329 G2 box; other site 1033837003330 G3 box; other site 1033837003331 Switch II region; other site 1033837003332 G4 box; other site 1033837003333 G5 box; other site 1033837003334 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1033837003335 FOG: CBS domain [General function prediction only]; Region: COG0517 1033837003336 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1033837003337 Transporter associated domain; Region: CorC_HlyC; smart01091 1033837003338 recombination regulator RecX; Provisional; Region: recX; PRK14135 1033837003339 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1033837003340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033837003341 S-adenosylmethionine binding site [chemical binding]; other site 1033837003342 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1033837003343 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1033837003344 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1033837003345 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1033837003346 dimer interface [polypeptide binding]; other site 1033837003347 active site 1033837003348 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1033837003349 homodimer interface [polypeptide binding]; other site 1033837003350 catalytic residues [active] 1033837003351 NAD binding site [chemical binding]; other site 1033837003352 substrate binding pocket [chemical binding]; other site 1033837003353 flexible flap; other site 1033837003354 putative acyltransferase; Provisional; Region: PRK05790 1033837003355 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1033837003356 dimer interface [polypeptide binding]; other site 1033837003357 active site 1033837003358 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1033837003359 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1033837003360 active site 1033837003361 tetramer interface; other site 1033837003362 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1033837003363 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1033837003364 methionine aminopeptidase; Provisional; Region: PRK08671 1033837003365 active site 1033837003366 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1033837003367 Predicted membrane protein [Function unknown]; Region: COG2246 1033837003368 GtrA-like protein; Region: GtrA; pfam04138 1033837003369 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1033837003370 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1033837003371 active site 1033837003372 homodimer interface [polypeptide binding]; other site 1033837003373 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1033837003374 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1033837003375 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1033837003376 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1033837003377 ATP binding site [chemical binding]; other site 1033837003378 putative Mg++ binding site [ion binding]; other site 1033837003379 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033837003380 nucleotide binding region [chemical binding]; other site 1033837003381 ATP-binding site [chemical binding]; other site 1033837003382 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1033837003383 active site 1033837003384 Amino acid permease; Region: AA_permease_2; pfam13520 1033837003385 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033837003386 active site 1033837003387 Domain of unknown function DUF21; Region: DUF21; pfam01595 1033837003388 FOG: CBS domain [General function prediction only]; Region: COG0517 1033837003389 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1033837003390 Transporter associated domain; Region: CorC_HlyC; smart01091 1033837003391 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1033837003392 putative FMN binding site [chemical binding]; other site 1033837003393 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1033837003394 HPr interaction site; other site 1033837003395 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1033837003396 active site 1033837003397 phosphorylation site [posttranslational modification] 1033837003398 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1033837003399 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1033837003400 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1033837003401 putative active site [active] 1033837003402 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1033837003403 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1033837003404 active site 1033837003405 nucleophile elbow; other site 1033837003406 putative phosphoketolase; Provisional; Region: PRK05261 1033837003407 XFP N-terminal domain; Region: XFP_N; pfam09364 1033837003408 XFP C-terminal domain; Region: XFP_C; pfam09363 1033837003409 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1033837003410 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1033837003411 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1033837003412 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1033837003413 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1033837003414 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1033837003415 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1033837003416 Fic family protein [Function unknown]; Region: COG3177 1033837003417 Fic/DOC family; Region: Fic; pfam02661 1033837003418 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033837003419 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1033837003420 DNA-binding site [nucleotide binding]; DNA binding site 1033837003421 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1033837003422 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1033837003423 active site 1033837003424 tetramer interface [polypeptide binding]; other site 1033837003425 K+ potassium transporter; Region: K_trans; pfam02705 1033837003426 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1033837003427 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1033837003428 active site 1033837003429 dimer interface [polypeptide binding]; other site 1033837003430 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1033837003431 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1033837003432 substrate binding site [chemical binding]; other site 1033837003433 dimer interface [polypeptide binding]; other site 1033837003434 ATP binding site [chemical binding]; other site 1033837003435 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1033837003436 nucleotide binding site/active site [active] 1033837003437 HIT family signature motif; other site 1033837003438 catalytic residue [active] 1033837003439 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1033837003440 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1033837003441 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837003442 Walker A/P-loop; other site 1033837003443 ATP binding site [chemical binding]; other site 1033837003444 Q-loop/lid; other site 1033837003445 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1033837003446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837003447 ABC transporter signature motif; other site 1033837003448 Walker B; other site 1033837003449 D-loop; other site 1033837003450 H-loop/switch region; other site 1033837003451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837003452 AAA domain; Region: AAA_21; pfam13304 1033837003453 Walker A/P-loop; other site 1033837003454 ATP binding site [chemical binding]; other site 1033837003455 Q-loop/lid; other site 1033837003456 ABC transporter signature motif; other site 1033837003457 Walker B; other site 1033837003458 D-loop; other site 1033837003459 H-loop/switch region; other site 1033837003460 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 1033837003461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837003462 dimer interface [polypeptide binding]; other site 1033837003463 conserved gate region; other site 1033837003464 putative PBP binding loops; other site 1033837003465 ABC-ATPase subunit interface; other site 1033837003466 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1033837003467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837003468 dimer interface [polypeptide binding]; other site 1033837003469 conserved gate region; other site 1033837003470 putative PBP binding loops; other site 1033837003471 ABC-ATPase subunit interface; other site 1033837003472 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1033837003473 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033837003474 substrate binding pocket [chemical binding]; other site 1033837003475 membrane-bound complex binding site; other site 1033837003476 hinge residues; other site 1033837003477 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1033837003478 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1033837003479 Walker A/P-loop; other site 1033837003480 ATP binding site [chemical binding]; other site 1033837003481 Q-loop/lid; other site 1033837003482 ABC transporter signature motif; other site 1033837003483 Walker B; other site 1033837003484 D-loop; other site 1033837003485 H-loop/switch region; other site 1033837003486 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1033837003487 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1033837003488 Sugar specificity; other site 1033837003489 Pyrimidine base specificity; other site 1033837003490 ATP-binding site [chemical binding]; other site 1033837003491 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1033837003492 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1033837003493 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033837003494 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1033837003495 Walker A/P-loop; other site 1033837003496 ATP binding site [chemical binding]; other site 1033837003497 Q-loop/lid; other site 1033837003498 ABC transporter signature motif; other site 1033837003499 Walker B; other site 1033837003500 D-loop; other site 1033837003501 H-loop/switch region; other site 1033837003502 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033837003503 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837003504 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1033837003505 Walker A/P-loop; other site 1033837003506 ATP binding site [chemical binding]; other site 1033837003507 Q-loop/lid; other site 1033837003508 ABC transporter signature motif; other site 1033837003509 Walker B; other site 1033837003510 D-loop; other site 1033837003511 H-loop/switch region; other site 1033837003512 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1033837003513 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1033837003514 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1033837003515 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1033837003516 catalytic triad [active] 1033837003517 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1033837003518 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1033837003519 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033837003520 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033837003521 ABC transporter; Region: ABC_tran_2; pfam12848 1033837003522 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033837003523 drug efflux system protein MdtG; Provisional; Region: PRK09874 1033837003524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033837003525 putative substrate translocation pore; other site 1033837003526 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1033837003527 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033837003528 active site 1033837003529 uracil transporter; Provisional; Region: PRK10720 1033837003530 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1033837003531 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1033837003532 Probable transposase; Region: OrfB_IS605; pfam01385 1033837003533 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1033837003534 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 1033837003535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033837003536 non-specific DNA binding site [nucleotide binding]; other site 1033837003537 salt bridge; other site 1033837003538 sequence-specific DNA binding site [nucleotide binding]; other site 1033837003539 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1033837003540 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837003541 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1033837003542 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033837003543 Coenzyme A binding pocket [chemical binding]; other site 1033837003544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1033837003545 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1033837003546 PemK-like protein; Region: PemK; cl00995 1033837003547 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1033837003548 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1033837003549 H+ Antiporter protein; Region: 2A0121; TIGR00900 1033837003550 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1033837003551 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1033837003552 dimer interface [polypeptide binding]; other site 1033837003553 active site 1033837003554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1033837003555 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1033837003556 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1033837003557 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1033837003558 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1033837003559 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1033837003560 nucleotide binding region [chemical binding]; other site 1033837003561 ATP-binding site [chemical binding]; other site 1033837003562 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1033837003563 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1033837003564 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1033837003565 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033837003566 non-specific DNA binding site [nucleotide binding]; other site 1033837003567 salt bridge; other site 1033837003568 sequence-specific DNA binding site [nucleotide binding]; other site 1033837003569 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1033837003570 active site 1033837003571 DNA binding site [nucleotide binding] 1033837003572 Int/Topo IB signature motif; other site 1033837003573 PemK-like protein; Region: PemK; pfam02452 1033837003574 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1033837003575 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033837003576 non-specific DNA binding site [nucleotide binding]; other site 1033837003577 salt bridge; other site 1033837003578 sequence-specific DNA binding site [nucleotide binding]; other site 1033837003579 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 1033837003580 DNA polymerase III subunit beta; Validated; Region: PRK05643 1033837003581 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1033837003582 putative DNA binding surface [nucleotide binding]; other site 1033837003583 dimer interface [polypeptide binding]; other site 1033837003584 beta-clamp/clamp loader binding surface; other site 1033837003585 beta-clamp/translesion DNA polymerase binding surface; other site 1033837003586 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1033837003587 Helix-turn-helix domain; Region: HTH_38; pfam13936 1033837003588 Integrase core domain; Region: rve; pfam00665 1033837003589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033837003590 non-specific DNA binding site [nucleotide binding]; other site 1033837003591 salt bridge; other site 1033837003592 sequence-specific DNA binding site [nucleotide binding]; other site 1033837003593 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1033837003594 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1033837003595 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1033837003596 active site 1033837003597 substrate binding site [chemical binding]; other site 1033837003598 ATP binding site [chemical binding]; other site 1033837003599 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1033837003600 activation loop (A-loop); other site 1033837003601 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1033837003602 active site 1033837003603 zinc binding site [ion binding]; other site 1033837003604 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033837003605 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837003606 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1033837003607 Walker A/P-loop; other site 1033837003608 ATP binding site [chemical binding]; other site 1033837003609 Q-loop/lid; other site 1033837003610 ABC transporter signature motif; other site 1033837003611 Walker B; other site 1033837003612 D-loop; other site 1033837003613 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1033837003614 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033837003615 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1033837003616 Walker A/P-loop; other site 1033837003617 ATP binding site [chemical binding]; other site 1033837003618 Q-loop/lid; other site 1033837003619 ABC transporter signature motif; other site 1033837003620 Walker B; other site 1033837003621 D-loop; other site 1033837003622 H-loop/switch region; other site 1033837003623 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1033837003624 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1033837003625 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1033837003626 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1033837003627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837003628 Walker A/P-loop; other site 1033837003629 ATP binding site [chemical binding]; other site 1033837003630 Q-loop/lid; other site 1033837003631 ABC transporter signature motif; other site 1033837003632 Walker B; other site 1033837003633 D-loop; other site 1033837003634 H-loop/switch region; other site 1033837003635 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1033837003636 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1033837003637 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1033837003638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1033837003639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033837003640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033837003641 putative substrate translocation pore; other site 1033837003642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033837003643 Coenzyme A binding pocket [chemical binding]; other site 1033837003644 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 1033837003645 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1033837003646 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1033837003647 DNA methylase; Region: N6_N4_Mtase; pfam01555 1033837003648 DNA methylase; Region: N6_N4_Mtase; pfam01555 1033837003649 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1033837003650 non-specific DNA binding site [nucleotide binding]; other site 1033837003651 salt bridge; other site 1033837003652 sequence-specific DNA binding site [nucleotide binding]; other site 1033837003653 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1033837003654 DNA-binding site [nucleotide binding]; DNA binding site 1033837003655 RNA-binding motif; other site 1033837003656 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1033837003657 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1033837003658 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1033837003659 Helix-turn-helix domain; Region: HTH_38; pfam13936 1033837003660 Integrase core domain; Region: rve; pfam00665 1033837003661 TRAM domain; Region: TRAM; cl01282 1033837003662 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1033837003663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033837003664 S-adenosylmethionine binding site [chemical binding]; other site 1033837003665 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1033837003666 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1033837003667 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1033837003668 putative lipid kinase; Reviewed; Region: PRK13337 1033837003669 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1033837003670 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1033837003671 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1033837003672 GatB domain; Region: GatB_Yqey; smart00845 1033837003673 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1033837003674 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1033837003675 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1033837003676 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1033837003677 putative dimer interface [polypeptide binding]; other site 1033837003678 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 1033837003679 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1033837003680 putative dimer interface [polypeptide binding]; other site 1033837003681 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1033837003682 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1033837003683 nucleotide binding pocket [chemical binding]; other site 1033837003684 K-X-D-G motif; other site 1033837003685 catalytic site [active] 1033837003686 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1033837003687 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1033837003688 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1033837003689 Dimer interface [polypeptide binding]; other site 1033837003690 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1033837003691 Part of AAA domain; Region: AAA_19; pfam13245 1033837003692 Family description; Region: UvrD_C_2; pfam13538 1033837003693 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1033837003694 SprT homologues; Region: SprT; cl01182 1033837003695 hypothetical protein; Provisional; Region: PRK04351 1033837003696 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1033837003697 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1033837003698 Polysaccharide biosynthesis protein; Region: Polysacc_synt; pfam01943 1033837003699 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1033837003700 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1033837003701 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1033837003702 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1033837003703 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1033837003704 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1033837003705 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1033837003706 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1033837003707 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1033837003708 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1033837003709 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1033837003710 homodimer interface [polypeptide binding]; other site 1033837003711 NAD binding pocket [chemical binding]; other site 1033837003712 ATP binding pocket [chemical binding]; other site 1033837003713 Mg binding site [ion binding]; other site 1033837003714 active-site loop [active] 1033837003715 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1033837003716 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1033837003717 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1033837003718 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1033837003719 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1033837003720 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1033837003721 active site 1033837003722 nucleotide binding site [chemical binding]; other site 1033837003723 HIGH motif; other site 1033837003724 KMSKS motif; other site 1033837003725 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1033837003726 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033837003727 DNA-binding site [nucleotide binding]; DNA binding site 1033837003728 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1033837003729 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837003730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837003731 Walker A/P-loop; other site 1033837003732 ATP binding site [chemical binding]; other site 1033837003733 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 1033837003734 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1033837003735 substrate binding [chemical binding]; other site 1033837003736 active site 1033837003737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837003738 dimer interface [polypeptide binding]; other site 1033837003739 conserved gate region; other site 1033837003740 putative PBP binding loops; other site 1033837003741 ABC-ATPase subunit interface; other site 1033837003742 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1033837003743 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033837003744 DNA binding site [nucleotide binding] 1033837003745 domain linker motif; other site 1033837003746 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1033837003747 dimerization interface [polypeptide binding]; other site 1033837003748 ligand binding site [chemical binding]; other site 1033837003749 sodium binding site [ion binding]; other site 1033837003750 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1033837003751 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1033837003752 active site 1033837003753 catalytic site [active] 1033837003754 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1033837003755 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1033837003756 catalytic core [active] 1033837003757 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1033837003758 catalytic core [active] 1033837003759 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 1033837003760 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 1033837003761 AAA ATPase domain; Region: AAA_16; pfam13191 1033837003762 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 1033837003763 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1033837003764 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1033837003765 active site 1033837003766 metal binding site [ion binding]; metal-binding site 1033837003767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1033837003768 Zeta toxin; Region: Zeta_toxin; pfam06414 1033837003769 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1033837003770 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1033837003771 active site 1033837003772 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1033837003773 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1033837003774 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1033837003775 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1033837003776 peptide binding site [polypeptide binding]; other site 1033837003777 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1033837003778 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1033837003779 active site 1033837003780 metal binding site [ion binding]; metal-binding site 1033837003781 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1033837003782 benzoate transport; Region: 2A0115; TIGR00895 1033837003783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033837003784 putative substrate translocation pore; other site 1033837003785 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1033837003786 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1033837003787 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1033837003788 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1033837003789 putative active site [active] 1033837003790 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1033837003791 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1033837003792 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1033837003793 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1033837003794 DNA-binding site [nucleotide binding]; DNA binding site 1033837003795 FCD domain; Region: FCD; pfam07729 1033837003796 DNA polymerase IV; Reviewed; Region: PRK03103 1033837003797 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1033837003798 active site 1033837003799 DNA binding site [nucleotide binding] 1033837003800 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1033837003801 Fic/DOC family; Region: Fic; pfam02661 1033837003802 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1033837003803 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033837003804 ATP binding site [chemical binding]; other site 1033837003805 putative Mg++ binding site [ion binding]; other site 1033837003806 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033837003807 nucleotide binding region [chemical binding]; other site 1033837003808 ATP-binding site [chemical binding]; other site 1033837003809 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 1033837003810 AAA ATPase domain; Region: AAA_16; pfam13191 1033837003811 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1033837003812 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1033837003813 active site 1033837003814 metal-binding site [ion binding] 1033837003815 nucleotide-binding site [chemical binding]; other site 1033837003816 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 1033837003817 active site 1033837003818 Ap4A binding cleft/pocket [chemical binding]; other site 1033837003819 P4 phosphate binding site; other site 1033837003820 nudix motif; other site 1033837003821 putative P2/P3 phosphate binding site [ion binding]; other site 1033837003822 Acetokinase family; Region: Acetate_kinase; cl17229 1033837003823 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1033837003824 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1033837003825 glutaminase active site [active] 1033837003826 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1033837003827 dimer interface [polypeptide binding]; other site 1033837003828 active site 1033837003829 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1033837003830 dimer interface [polypeptide binding]; other site 1033837003831 active site 1033837003832 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1033837003833 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1033837003834 putative catalytic cysteine [active] 1033837003835 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1033837003836 putative active site [active] 1033837003837 metal binding site [ion binding]; metal-binding site 1033837003838 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1033837003839 Domain of unknown function (DUF956); Region: DUF956; pfam06115 1033837003840 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1033837003841 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1033837003842 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1033837003843 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1033837003844 active pocket/dimerization site; other site 1033837003845 active site 1033837003846 phosphorylation site [posttranslational modification] 1033837003847 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1033837003848 active site 1033837003849 phosphorylation site [posttranslational modification] 1033837003850 seryl-tRNA synthetase; Provisional; Region: PRK05431 1033837003851 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1033837003852 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1033837003853 dimer interface [polypeptide binding]; other site 1033837003854 active site 1033837003855 motif 1; other site 1033837003856 motif 2; other site 1033837003857 motif 3; other site 1033837003858 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1033837003859 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1033837003860 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1033837003861 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1033837003862 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1033837003863 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1033837003864 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1033837003865 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1033837003866 NAD(P) binding site [chemical binding]; other site 1033837003867 catalytic residues [active] 1033837003868 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1033837003869 Double zinc ribbon; Region: DZR; pfam12773 1033837003870 MMPL family; Region: MMPL; pfam03176 1033837003871 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1033837003872 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1033837003873 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1033837003874 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1033837003875 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033837003876 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1033837003877 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1033837003878 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1033837003879 Cl binding site [ion binding]; other site 1033837003880 oligomer interface [polypeptide binding]; other site 1033837003881 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1033837003882 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1033837003883 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1033837003884 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1033837003885 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1033837003886 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1033837003887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837003888 dimer interface [polypeptide binding]; other site 1033837003889 conserved gate region; other site 1033837003890 ABC-ATPase subunit interface; other site 1033837003891 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1033837003892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837003893 dimer interface [polypeptide binding]; other site 1033837003894 conserved gate region; other site 1033837003895 putative PBP binding loops; other site 1033837003896 ABC-ATPase subunit interface; other site 1033837003897 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1033837003898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837003899 Walker A/P-loop; other site 1033837003900 ATP binding site [chemical binding]; other site 1033837003901 Q-loop/lid; other site 1033837003902 ABC transporter signature motif; other site 1033837003903 Walker B; other site 1033837003904 D-loop; other site 1033837003905 H-loop/switch region; other site 1033837003906 TOBE domain; Region: TOBE_2; pfam08402 1033837003907 Peptidase family C69; Region: Peptidase_C69; pfam03577 1033837003908 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1033837003909 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1033837003910 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 1033837003911 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1033837003912 active site 1033837003913 catalytic site [active] 1033837003914 substrate binding site [chemical binding]; other site 1033837003915 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 1033837003916 Predicted membrane protein [Function unknown]; Region: COG2323 1033837003917 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 1033837003918 Glucan-binding protein C; Region: GbpC; pfam08363 1033837003919 MucBP domain; Region: MucBP; pfam06458 1033837003920 PAS domain; Region: PAS_10; pfam13596 1033837003921 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1033837003922 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033837003923 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1033837003924 Walker A/P-loop; other site 1033837003925 ATP binding site [chemical binding]; other site 1033837003926 Q-loop/lid; other site 1033837003927 ABC transporter signature motif; other site 1033837003928 Walker B; other site 1033837003929 D-loop; other site 1033837003930 H-loop/switch region; other site 1033837003931 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1033837003932 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1033837003933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033837003934 active site 1033837003935 phosphorylation site [posttranslational modification] 1033837003936 intermolecular recognition site; other site 1033837003937 dimerization interface [polypeptide binding]; other site 1033837003938 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033837003939 DNA binding site [nucleotide binding] 1033837003940 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1033837003941 HAMP domain; Region: HAMP; pfam00672 1033837003942 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033837003943 dimer interface [polypeptide binding]; other site 1033837003944 phosphorylation site [posttranslational modification] 1033837003945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033837003946 ATP binding site [chemical binding]; other site 1033837003947 Mg2+ binding site [ion binding]; other site 1033837003948 G-X-G motif; other site 1033837003949 Predicted membrane protein [Function unknown]; Region: COG3212 1033837003950 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1033837003951 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1033837003952 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1033837003953 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1033837003954 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1033837003955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033837003956 Coenzyme A binding pocket [chemical binding]; other site 1033837003957 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1033837003958 MarR family; Region: MarR; pfam01047 1033837003959 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1033837003960 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1033837003961 peptide binding site [polypeptide binding]; other site 1033837003962 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1033837003963 Predicted membrane protein [Function unknown]; Region: COG3212 1033837003964 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1033837003965 elongation factor P; Validated; Region: PRK00529 1033837003966 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1033837003967 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1033837003968 RNA binding site [nucleotide binding]; other site 1033837003969 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1033837003970 RNA binding site [nucleotide binding]; other site 1033837003971 pantothenate kinase; Provisional; Region: PRK05439 1033837003972 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1033837003973 ATP-binding site [chemical binding]; other site 1033837003974 CoA-binding site [chemical binding]; other site 1033837003975 Mg2+-binding site [ion binding]; other site 1033837003976 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1033837003977 active site 1033837003978 catalytic triad [active] 1033837003979 oxyanion hole [active] 1033837003980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033837003981 Coenzyme A binding pocket [chemical binding]; other site 1033837003982 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1033837003983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837003984 Walker A/P-loop; other site 1033837003985 ATP binding site [chemical binding]; other site 1033837003986 Q-loop/lid; other site 1033837003987 ABC transporter signature motif; other site 1033837003988 Walker B; other site 1033837003989 D-loop; other site 1033837003990 H-loop/switch region; other site 1033837003991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837003992 dimer interface [polypeptide binding]; other site 1033837003993 conserved gate region; other site 1033837003994 putative PBP binding loops; other site 1033837003995 ABC-ATPase subunit interface; other site 1033837003996 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1033837003997 Part of AAA domain; Region: AAA_19; pfam13245 1033837003998 Family description; Region: UvrD_C_2; pfam13538 1033837003999 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 1033837004000 active site 1033837004001 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1033837004002 catalytic core [active] 1033837004003 FtsX-like permease family; Region: FtsX; pfam02687 1033837004004 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1033837004005 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1033837004006 Walker A/P-loop; other site 1033837004007 ATP binding site [chemical binding]; other site 1033837004008 Q-loop/lid; other site 1033837004009 ABC transporter signature motif; other site 1033837004010 Walker B; other site 1033837004011 D-loop; other site 1033837004012 H-loop/switch region; other site 1033837004013 Predicted membrane protein [Function unknown]; Region: COG4640 1033837004014 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 1033837004015 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1033837004016 active pocket/dimerization site; other site 1033837004017 active site 1033837004018 phosphorylation site [posttranslational modification] 1033837004019 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1033837004020 active site 1033837004021 homodimer interface [polypeptide binding]; other site 1033837004022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1033837004023 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1033837004024 Coenzyme A binding pocket [chemical binding]; other site 1033837004025 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1033837004026 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1033837004027 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1033837004028 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1033837004029 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1033837004030 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1033837004031 DNA binding residues [nucleotide binding] 1033837004032 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1033837004033 catalytic residues [active] 1033837004034 catalytic nucleophile [active] 1033837004035 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1033837004036 Probable transposase; Region: OrfB_IS605; pfam01385 1033837004037 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1033837004038 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1033837004039 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1033837004040 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1033837004041 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1033837004042 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1033837004043 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1033837004044 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1033837004045 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1033837004046 MULE transposase domain; Region: MULE; pfam10551 1033837004047 Helix-turn-helix domain; Region: HTH_18; pfam12833 1033837004048 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033837004049 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1033837004050 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033837004051 substrate binding pocket [chemical binding]; other site 1033837004052 membrane-bound complex binding site; other site 1033837004053 hinge residues; other site 1033837004054 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1033837004055 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1033837004056 Walker A/P-loop; other site 1033837004057 ATP binding site [chemical binding]; other site 1033837004058 Q-loop/lid; other site 1033837004059 ABC transporter signature motif; other site 1033837004060 Walker B; other site 1033837004061 D-loop; other site 1033837004062 H-loop/switch region; other site 1033837004063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837004064 dimer interface [polypeptide binding]; other site 1033837004065 conserved gate region; other site 1033837004066 putative PBP binding loops; other site 1033837004067 ABC-ATPase subunit interface; other site 1033837004068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837004069 dimer interface [polypeptide binding]; other site 1033837004070 conserved gate region; other site 1033837004071 putative PBP binding loops; other site 1033837004072 ABC-ATPase subunit interface; other site 1033837004073 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1033837004074 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1033837004075 DNA binding residues [nucleotide binding] 1033837004076 putative dimer interface [polypeptide binding]; other site 1033837004077 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 1033837004078 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1033837004079 maltose O-acetyltransferase; Provisional; Region: PRK10092 1033837004080 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1033837004081 putative trimer interface [polypeptide binding]; other site 1033837004082 putative CoA binding site [chemical binding]; other site 1033837004083 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1033837004084 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1033837004085 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761 1033837004086 DNA binding residues [nucleotide binding] 1033837004087 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1033837004088 catalytic residues [active] 1033837004089 catalytic nucleophile [active] 1033837004090 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1033837004091 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1033837004092 MULE transposase domain; Region: MULE; pfam10551 1033837004093 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1033837004094 active site 1033837004095 KMSKS motif; other site 1033837004096 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1033837004097 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1033837004098 putative ADP-binding pocket [chemical binding]; other site 1033837004099 LicD family; Region: LicD; cl01378 1033837004100 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1033837004101 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1033837004102 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1033837004103 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1033837004104 active site 1033837004105 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1033837004106 trimer interface [polypeptide binding]; other site 1033837004107 active site 1033837004108 substrate binding site [chemical binding]; other site 1033837004109 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1033837004110 CoA binding site [chemical binding]; other site 1033837004111 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1033837004112 putative CoA binding site [chemical binding]; other site 1033837004113 putative trimer interface [polypeptide binding]; other site 1033837004114 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1033837004115 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1033837004116 active site 1033837004117 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101 1033837004118 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 1033837004119 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1033837004120 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1033837004121 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1033837004122 active site 1033837004123 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1033837004124 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1033837004125 Chain length determinant protein; Region: Wzz; cl15801 1033837004126 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1033837004127 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1033837004128 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1033837004129 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1033837004130 HflX GTPase family; Region: HflX; cd01878 1033837004131 G1 box; other site 1033837004132 GTP/Mg2+ binding site [chemical binding]; other site 1033837004133 Switch I region; other site 1033837004134 G2 box; other site 1033837004135 G3 box; other site 1033837004136 Switch II region; other site 1033837004137 G4 box; other site 1033837004138 G5 box; other site 1033837004139 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1033837004140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1033837004141 Probable transposase; Region: OrfB_IS605; pfam01385 1033837004142 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1033837004143 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1033837004144 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1033837004145 DNA binding residues [nucleotide binding] 1033837004146 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1033837004147 catalytic residues [active] 1033837004148 catalytic nucleophile [active] 1033837004149 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1033837004150 NlpC/P60 family; Region: NLPC_P60; pfam00877 1033837004151 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1033837004152 NlpC/P60 family; Region: NLPC_P60; pfam00877 1033837004153 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1033837004154 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1033837004155 catalytic site [active] 1033837004156 G-X2-G-X-G-K; other site 1033837004157 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 1033837004158 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1033837004159 dimer interface [polypeptide binding]; other site 1033837004160 putative radical transfer pathway; other site 1033837004161 diiron center [ion binding]; other site 1033837004162 tyrosyl radical; other site 1033837004163 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1033837004164 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1033837004165 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1033837004166 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1033837004167 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033837004168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837004169 Walker A/P-loop; other site 1033837004170 ATP binding site [chemical binding]; other site 1033837004171 Q-loop/lid; other site 1033837004172 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033837004173 ABC transporter signature motif; other site 1033837004174 Walker B; other site 1033837004175 D-loop; other site 1033837004176 ABC transporter; Region: ABC_tran_2; pfam12848 1033837004177 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1033837004178 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1033837004179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1033837004180 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1033837004181 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1033837004182 oligoendopeptidase F; Region: pepF; TIGR00181 1033837004183 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1033837004184 active site 1033837004185 Zn binding site [ion binding]; other site 1033837004186 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1033837004187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033837004188 non-specific DNA binding site [nucleotide binding]; other site 1033837004189 salt bridge; other site 1033837004190 sequence-specific DNA binding site [nucleotide binding]; other site 1033837004191 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1033837004192 substrate binding site [chemical binding]; other site 1033837004193 THF binding site; other site 1033837004194 zinc-binding site [ion binding]; other site 1033837004195 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1033837004196 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1033837004197 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1033837004198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1033837004199 Probable transposase; Region: OrfB_IS605; pfam01385 1033837004200 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1033837004201 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1033837004202 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1033837004203 DNA binding residues [nucleotide binding] 1033837004204 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1033837004205 catalytic residues [active] 1033837004206 catalytic nucleophile [active] 1033837004207 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1033837004208 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1033837004209 dimer interface [polypeptide binding]; other site 1033837004210 putative PBP binding regions; other site 1033837004211 ABC-ATPase subunit interface; other site 1033837004212 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1033837004213 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1033837004214 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1033837004215 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1033837004216 intersubunit interface [polypeptide binding]; other site 1033837004217 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1033837004218 dimerization interface [polypeptide binding]; other site 1033837004219 putative DNA binding site [nucleotide binding]; other site 1033837004220 putative Zn2+ binding site [ion binding]; other site 1033837004221 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1033837004222 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1033837004223 active site 1033837004224 phosphorylation site [posttranslational modification] 1033837004225 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1033837004226 active site 1033837004227 P-loop; other site 1033837004228 phosphorylation site [posttranslational modification] 1033837004229 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1033837004230 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1033837004231 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1033837004232 putative substrate binding site [chemical binding]; other site 1033837004233 putative ATP binding site [chemical binding]; other site 1033837004234 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1033837004235 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1033837004236 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1033837004237 Fic family protein [Function unknown]; Region: COG3177 1033837004238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033837004239 salt bridge; other site 1033837004240 non-specific DNA binding site [nucleotide binding]; other site 1033837004241 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1033837004242 sequence-specific DNA binding site [nucleotide binding]; other site 1033837004243 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 1033837004244 AAA domain; Region: AAA_14; pfam13173 1033837004245 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 1033837004246 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1033837004247 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1033837004248 AAA domain; Region: AAA_14; pfam13173 1033837004249 alpha-glucosidase; Provisional; Region: PRK10426 1033837004250 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1033837004251 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 1033837004252 trimer interface [polypeptide binding]; other site 1033837004253 active site 1033837004254 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 1033837004255 catalytic site [active] 1033837004256 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1033837004257 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1033837004258 aspartate racemase; Region: asp_race; TIGR00035 1033837004259 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1033837004260 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1033837004261 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1033837004262 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1033837004263 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1033837004264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1033837004265 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033837004266 dimer interface [polypeptide binding]; other site 1033837004267 phosphorylation site [posttranslational modification] 1033837004268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033837004269 ATP binding site [chemical binding]; other site 1033837004270 Mg2+ binding site [ion binding]; other site 1033837004271 G-X-G motif; other site 1033837004272 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1033837004273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033837004274 active site 1033837004275 phosphorylation site [posttranslational modification] 1033837004276 intermolecular recognition site; other site 1033837004277 dimerization interface [polypeptide binding]; other site 1033837004278 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033837004279 DNA binding site [nucleotide binding] 1033837004280 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1033837004281 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033837004282 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1033837004283 Walker A/P-loop; other site 1033837004284 ATP binding site [chemical binding]; other site 1033837004285 Q-loop/lid; other site 1033837004286 ABC transporter signature motif; other site 1033837004287 Walker B; other site 1033837004288 D-loop; other site 1033837004289 H-loop/switch region; other site 1033837004290 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1033837004291 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033837004292 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837004293 Walker A/P-loop; other site 1033837004294 ATP binding site [chemical binding]; other site 1033837004295 Q-loop/lid; other site 1033837004296 ABC transporter signature motif; other site 1033837004297 Walker B; other site 1033837004298 D-loop; other site 1033837004299 H-loop/switch region; other site 1033837004300 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 1033837004301 GTP-binding protein YchF; Reviewed; Region: PRK09601 1033837004302 YchF GTPase; Region: YchF; cd01900 1033837004303 G1 box; other site 1033837004304 GTP/Mg2+ binding site [chemical binding]; other site 1033837004305 Switch I region; other site 1033837004306 G2 box; other site 1033837004307 Switch II region; other site 1033837004308 G3 box; other site 1033837004309 G4 box; other site 1033837004310 G5 box; other site 1033837004311 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1033837004312 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1033837004313 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1033837004314 ParB-like nuclease domain; Region: ParB; smart00470 1033837004315 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1033837004316 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1033837004317 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1033837004318 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1033837004319 ParB-like nuclease domain; Region: ParB; smart00470 1033837004320 KorB domain; Region: KorB; pfam08535 1033837004321 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1033837004322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033837004323 S-adenosylmethionine binding site [chemical binding]; other site 1033837004324 Colicin V production protein; Region: Colicin_V; pfam02674 1033837004325 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1033837004326 ApbE family; Region: ApbE; pfam02424 1033837004327 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1033837004328 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 1033837004329 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1033837004330 Predicted flavoprotein [General function prediction only]; Region: COG0431 1033837004331 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1033837004332 Predicted flavoprotein [General function prediction only]; Region: COG0431 1033837004333 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1033837004334 WHG domain; Region: WHG; pfam13305 1033837004335 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1033837004336 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1033837004337 Walker A/P-loop; other site 1033837004338 ATP binding site [chemical binding]; other site 1033837004339 Q-loop/lid; other site 1033837004340 ABC transporter signature motif; other site 1033837004341 Walker B; other site 1033837004342 D-loop; other site 1033837004343 H-loop/switch region; other site 1033837004344 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1033837004345 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1033837004346 FtsX-like permease family; Region: FtsX; pfam02687 1033837004347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1033837004348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033837004349 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1033837004350 catalytic core [active] 1033837004351 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1033837004352 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1033837004353 catalytic site [active] 1033837004354 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1033837004355 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1033837004356 DNA binding residues [nucleotide binding] 1033837004357 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1033837004358 catalytic residues [active] 1033837004359 catalytic nucleophile [active] 1033837004360 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1033837004361 Probable transposase; Region: OrfB_IS605; pfam01385 1033837004362 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1033837004363 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1033837004364 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1033837004365 nucleotide binding site/active site [active] 1033837004366 HIT family signature motif; other site 1033837004367 catalytic residue [active] 1033837004368 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1033837004369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033837004370 putative substrate translocation pore; other site 1033837004371 POT family; Region: PTR2; cl17359 1033837004372 Peptidase family M1; Region: Peptidase_M1; pfam01433 1033837004373 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1033837004374 Zn binding site [ion binding]; other site 1033837004375 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 1033837004376 drug efflux system protein MdtG; Provisional; Region: PRK09874 1033837004377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033837004378 putative substrate translocation pore; other site 1033837004379 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1033837004380 putative ADP-ribose binding site [chemical binding]; other site 1033837004381 putative active site [active] 1033837004382 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1033837004383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837004384 dimer interface [polypeptide binding]; other site 1033837004385 conserved gate region; other site 1033837004386 putative PBP binding loops; other site 1033837004387 ABC-ATPase subunit interface; other site 1033837004388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837004389 dimer interface [polypeptide binding]; other site 1033837004390 conserved gate region; other site 1033837004391 ABC-ATPase subunit interface; other site 1033837004392 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1033837004393 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1033837004394 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1033837004395 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1033837004396 Walker A/P-loop; other site 1033837004397 ATP binding site [chemical binding]; other site 1033837004398 Q-loop/lid; other site 1033837004399 ABC transporter signature motif; other site 1033837004400 Walker B; other site 1033837004401 D-loop; other site 1033837004402 H-loop/switch region; other site 1033837004403 TOBE domain; Region: TOBE_2; pfam08402 1033837004404 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1033837004405 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837004406 motif II; other site 1033837004407 maltose phosphorylase; Provisional; Region: PRK13807 1033837004408 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1033837004409 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1033837004410 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1033837004411 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1033837004412 propionate/acetate kinase; Provisional; Region: PRK12379 1033837004413 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1033837004414 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1033837004415 DNA binding site [nucleotide binding] 1033837004416 domain linker motif; other site 1033837004417 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1033837004418 ligand binding site [chemical binding]; other site 1033837004419 dimerization interface [polypeptide binding]; other site 1033837004420 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1033837004421 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1033837004422 glycerol kinase; Provisional; Region: glpK; PRK00047 1033837004423 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1033837004424 N- and C-terminal domain interface [polypeptide binding]; other site 1033837004425 active site 1033837004426 MgATP binding site [chemical binding]; other site 1033837004427 catalytic site [active] 1033837004428 metal binding site [ion binding]; metal-binding site 1033837004429 glycerol binding site [chemical binding]; other site 1033837004430 homotetramer interface [polypeptide binding]; other site 1033837004431 homodimer interface [polypeptide binding]; other site 1033837004432 FBP binding site [chemical binding]; other site 1033837004433 protein IIAGlc interface [polypeptide binding]; other site 1033837004434 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1033837004435 dimer interface [polypeptide binding]; other site 1033837004436 substrate binding site [chemical binding]; other site 1033837004437 ATP binding site [chemical binding]; other site 1033837004438 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1033837004439 catalytic triad [active] 1033837004440 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1033837004441 NlpC/P60 family; Region: NLPC_P60; pfam00877 1033837004442 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033837004443 non-specific DNA binding site [nucleotide binding]; other site 1033837004444 salt bridge; other site 1033837004445 sequence-specific DNA binding site [nucleotide binding]; other site 1033837004446 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1033837004447 EamA-like transporter family; Region: EamA; pfam00892 1033837004448 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1033837004449 EamA-like transporter family; Region: EamA; pfam00892 1033837004450 EamA-like transporter family; Region: EamA; pfam00892 1033837004451 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1033837004452 EamA-like transporter family; Region: EamA; pfam00892 1033837004453 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 1033837004454 Mg++ binding site [ion binding]; other site 1033837004455 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1033837004456 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1033837004457 putative active site [active] 1033837004458 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1033837004459 HicB family; Region: HicB; pfam05534 1033837004460 adenylosuccinate lyase; Provisional; Region: PRK07492 1033837004461 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1033837004462 tetramer interface [polypeptide binding]; other site 1033837004463 active site 1033837004464 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1033837004465 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1033837004466 GDP-binding site [chemical binding]; other site 1033837004467 ACT binding site; other site 1033837004468 IMP binding site; other site 1033837004469 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1033837004470 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1033837004471 active site 1033837004472 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 1033837004473 catalytic triad [active] 1033837004474 oxyanion hole [active] 1033837004475 active site 1033837004476 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1033837004477 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1033837004478 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 1033837004479 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1033837004480 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1033837004481 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1033837004482 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1033837004483 Predicted membrane protein [Function unknown]; Region: COG4905 1033837004484 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1033837004485 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1033837004486 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1033837004487 enolase; Provisional; Region: eno; PRK00077 1033837004488 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1033837004489 dimer interface [polypeptide binding]; other site 1033837004490 metal binding site [ion binding]; metal-binding site 1033837004491 substrate binding pocket [chemical binding]; other site 1033837004492 Replication initiation factor; Region: Rep_trans; pfam02486 1033837004493 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1033837004494 MgtC family; Region: MgtC; pfam02308 1033837004495 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 1033837004496 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1033837004497 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1033837004498 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1033837004499 nucleotide binding site [chemical binding]; other site 1033837004500 EDD domain protein, DegV family; Region: DegV; TIGR00762 1033837004501 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1033837004502 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1033837004503 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033837004504 membrane-bound complex binding site; other site 1033837004505 hinge residues; other site 1033837004506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1033837004507 replicative DNA helicase; Region: DnaB; TIGR00665 1033837004508 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1033837004509 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1033837004510 Walker A motif; other site 1033837004511 ATP binding site [chemical binding]; other site 1033837004512 Walker B motif; other site 1033837004513 DNA binding loops [nucleotide binding] 1033837004514 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1033837004515 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1033837004516 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1033837004517 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1033837004518 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1033837004519 DHH family; Region: DHH; pfam01368 1033837004520 DHHA1 domain; Region: DHHA1; pfam02272 1033837004521 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1033837004522 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1033837004523 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1033837004524 dimer interface [polypeptide binding]; other site 1033837004525 ssDNA binding site [nucleotide binding]; other site 1033837004526 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1033837004527 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1033837004528 DNA gyrase subunit A; Validated; Region: PRK05560 1033837004529 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1033837004530 CAP-like domain; other site 1033837004531 active site 1033837004532 primary dimer interface [polypeptide binding]; other site 1033837004533 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1033837004534 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1033837004535 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1033837004536 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1033837004537 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1033837004538 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1033837004539 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1033837004540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033837004541 Mg2+ binding site [ion binding]; other site 1033837004542 G-X-G motif; other site 1033837004543 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1033837004544 anchoring element; other site 1033837004545 dimer interface [polypeptide binding]; other site 1033837004546 ATP binding site [chemical binding]; other site 1033837004547 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1033837004548 active site 1033837004549 putative metal-binding site [ion binding]; other site 1033837004550 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1033837004551 recombination protein F; Reviewed; Region: recF; PRK00064 1033837004552 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1033837004553 Walker A/P-loop; other site 1033837004554 ATP binding site [chemical binding]; other site 1033837004555 Q-loop/lid; other site 1033837004556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837004557 ABC transporter signature motif; other site 1033837004558 Walker B; other site 1033837004559 D-loop; other site 1033837004560 H-loop/switch region; other site 1033837004561 S4 domain; Region: S4_2; pfam13275 1033837004562 DNA polymerase III subunit beta; Validated; Region: PRK05643 1033837004563 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1033837004564 putative DNA binding surface [nucleotide binding]; other site 1033837004565 dimer interface [polypeptide binding]; other site 1033837004566 beta-clamp/clamp loader binding surface; other site 1033837004567 beta-clamp/translesion DNA polymerase binding surface; other site 1033837004568 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1033837004569 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1033837004570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033837004571 Walker A motif; other site 1033837004572 ATP binding site [chemical binding]; other site 1033837004573 Walker B motif; other site 1033837004574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1033837004575 arginine finger; other site 1033837004576 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1033837004577 DnaA box-binding interface [nucleotide binding]; other site 1033837004578 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1033837004579 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1033837004580 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1033837004581 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1033837004582 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1033837004583 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1033837004584 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1033837004585 G1 box; other site 1033837004586 GTP/Mg2+ binding site [chemical binding]; other site 1033837004587 Switch I region; other site 1033837004588 G2 box; other site 1033837004589 Switch II region; other site 1033837004590 G3 box; other site 1033837004591 G4 box; other site 1033837004592 G5 box; other site 1033837004593 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1033837004594 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1033837004595 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1033837004596 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1033837004597 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1033837004598 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1033837004599 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1033837004600 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1033837004601 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1033837004602 Cl- selectivity filter; other site 1033837004603 Cl- binding residues [ion binding]; other site 1033837004604 pore gating glutamate residue; other site 1033837004605 dimer interface [polypeptide binding]; other site 1033837004606 H+/Cl- coupling transport residue; other site 1033837004607 TrkA-C domain; Region: TrkA_C; pfam02080 1033837004608 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1033837004609 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1033837004610 ligand binding site [chemical binding]; other site 1033837004611 flexible hinge region; other site 1033837004612 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1033837004613 putative switch regulator; other site 1033837004614 non-specific DNA interactions [nucleotide binding]; other site 1033837004615 DNA binding site [nucleotide binding] 1033837004616 sequence specific DNA binding site [nucleotide binding]; other site 1033837004617 putative cAMP binding site [chemical binding]; other site 1033837004618 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1033837004619 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1033837004620 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1033837004621 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1033837004622 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1033837004623 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1033837004624 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1033837004625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1033837004626 Helix-turn-helix domain; Region: HTH_28; pfam13518 1033837004627 putative transposase OrfB; Reviewed; Region: PHA02517 1033837004628 HTH-like domain; Region: HTH_21; pfam13276 1033837004629 Integrase core domain; Region: rve; pfam00665 1033837004630 Integrase core domain; Region: rve_2; pfam13333 1033837004631 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1033837004632 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1033837004633 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1033837004634 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033837004635 non-specific DNA binding site [nucleotide binding]; other site 1033837004636 salt bridge; other site 1033837004637 sequence-specific DNA binding site [nucleotide binding]; other site 1033837004638 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1033837004639 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1033837004640 Uncharacterized conserved protein [Function unknown]; Region: COG2013 1033837004641 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1033837004642 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1033837004643 DNA binding residues [nucleotide binding] 1033837004644 dimer interface [polypeptide binding]; other site 1033837004645 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1033837004646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1033837004647 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1033837004648 active site 1033837004649 motif I; other site 1033837004650 motif II; other site 1033837004651 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1033837004652 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1033837004653 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1033837004654 Substrate-binding site [chemical binding]; other site 1033837004655 Substrate specificity [chemical binding]; other site 1033837004656 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1033837004657 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1033837004658 Substrate-binding site [chemical binding]; other site 1033837004659 Substrate specificity [chemical binding]; other site 1033837004660 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1033837004661 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1033837004662 active site 1033837004663 trimer interface [polypeptide binding]; other site 1033837004664 allosteric site; other site 1033837004665 active site lid [active] 1033837004666 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1033837004667 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1033837004668 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1033837004669 Domain of unknown function (DUF336); Region: DUF336; cl01249 1033837004670 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1033837004671 putative hexamer interface [polypeptide binding]; other site 1033837004672 putative hexagonal pore; other site 1033837004673 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1033837004674 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1033837004675 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1033837004676 Predicted flavoprotein [General function prediction only]; Region: COG0431 1033837004677 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1033837004678 G1 box; other site 1033837004679 GTP/Mg2+ binding site [chemical binding]; other site 1033837004680 G2 box; other site 1033837004681 Switch I region; other site 1033837004682 G3 box; other site 1033837004683 Switch II region; other site 1033837004684 G4 box; other site 1033837004685 G5 box; other site 1033837004686 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1033837004687 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1033837004688 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1033837004689 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1033837004690 Walker A/P-loop; other site 1033837004691 ATP binding site [chemical binding]; other site 1033837004692 Q-loop/lid; other site 1033837004693 ABC transporter signature motif; other site 1033837004694 Walker B; other site 1033837004695 D-loop; other site 1033837004696 H-loop/switch region; other site 1033837004697 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1033837004698 Walker A/P-loop; other site 1033837004699 ATP binding site [chemical binding]; other site 1033837004700 Q-loop/lid; other site 1033837004701 ABC transporter signature motif; other site 1033837004702 Walker B; other site 1033837004703 D-loop; other site 1033837004704 H-loop/switch region; other site 1033837004705 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1033837004706 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837004707 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1033837004708 DDE superfamily endonuclease; Region: DDE_4; cl17710 1033837004709 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1033837004710 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1033837004711 catalytic residues [active] 1033837004712 catalytic nucleophile [active] 1033837004713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033837004714 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1033837004715 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1033837004716 hypothetical protein; Validated; Region: PRK07121 1033837004717 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1033837004718 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033837004719 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1033837004720 dimerization interface [polypeptide binding]; other site 1033837004721 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1033837004722 Isochorismatase family; Region: Isochorismatase; pfam00857 1033837004723 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1033837004724 catalytic triad [active] 1033837004725 conserved cis-peptide bond; other site 1033837004726 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1033837004727 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1033837004728 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1033837004729 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1033837004730 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1033837004731 active site 1033837004732 AAA domain; Region: AAA_14; pfam13173 1033837004733 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1033837004734 Fic/DOC family; Region: Fic; pfam02661 1033837004735 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1033837004736 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1033837004737 Potassium binding sites [ion binding]; other site 1033837004738 Cesium cation binding sites [ion binding]; other site 1033837004739 AIR carboxylase; Region: AIRC; pfam00731 1033837004740 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1033837004741 ATP-grasp domain; Region: ATP-grasp; pfam02222 1033837004742 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1033837004743 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1033837004744 ATP binding site [chemical binding]; other site 1033837004745 active site 1033837004746 substrate binding site [chemical binding]; other site 1033837004747 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1033837004748 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1033837004749 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1033837004750 putative active site [active] 1033837004751 catalytic triad [active] 1033837004752 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1033837004753 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1033837004754 dimerization interface [polypeptide binding]; other site 1033837004755 ATP binding site [chemical binding]; other site 1033837004756 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1033837004757 dimerization interface [polypeptide binding]; other site 1033837004758 ATP binding site [chemical binding]; other site 1033837004759 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1033837004760 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1033837004761 active site 1033837004762 tetramer interface [polypeptide binding]; other site 1033837004763 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033837004764 active site 1033837004765 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1033837004766 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1033837004767 dimerization interface [polypeptide binding]; other site 1033837004768 putative ATP binding site [chemical binding]; other site 1033837004769 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1033837004770 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1033837004771 active site 1033837004772 substrate binding site [chemical binding]; other site 1033837004773 cosubstrate binding site; other site 1033837004774 catalytic site [active] 1033837004775 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1033837004776 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1033837004777 purine monophosphate binding site [chemical binding]; other site 1033837004778 dimer interface [polypeptide binding]; other site 1033837004779 putative catalytic residues [active] 1033837004780 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1033837004781 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1033837004782 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1033837004783 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1033837004784 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1033837004785 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1033837004786 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1033837004787 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1033837004788 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1033837004789 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1033837004790 active site 1033837004791 dimer interface [polypeptide binding]; other site 1033837004792 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1033837004793 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1033837004794 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1033837004795 putative active site [active] 1033837004796 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1033837004797 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1033837004798 TM-ABC transporter signature motif; other site 1033837004799 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1033837004800 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1033837004801 TM-ABC transporter signature motif; other site 1033837004802 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1033837004803 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1033837004804 Walker A/P-loop; other site 1033837004805 ATP binding site [chemical binding]; other site 1033837004806 Q-loop/lid; other site 1033837004807 ABC transporter signature motif; other site 1033837004808 Walker B; other site 1033837004809 D-loop; other site 1033837004810 H-loop/switch region; other site 1033837004811 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1033837004812 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1033837004813 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1033837004814 ligand binding site [chemical binding]; other site 1033837004815 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1033837004816 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1033837004817 MgtC family; Region: MgtC; pfam02308 1033837004818 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1033837004819 Double zinc ribbon; Region: DZR; pfam12773 1033837004820 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1033837004821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033837004822 S-adenosylmethionine binding site [chemical binding]; other site 1033837004823 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1033837004824 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1033837004825 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1033837004826 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1033837004827 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033837004828 ATP binding site [chemical binding]; other site 1033837004829 putative Mg++ binding site [ion binding]; other site 1033837004830 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1033837004831 nucleotide binding region [chemical binding]; other site 1033837004832 ATP-binding site [chemical binding]; other site 1033837004833 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1033837004834 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1033837004835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033837004836 S-adenosylmethionine binding site [chemical binding]; other site 1033837004837 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1033837004838 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1033837004839 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1033837004840 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1033837004841 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1033837004842 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1033837004843 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1033837004844 active site 1033837004845 catalytic tetrad [active] 1033837004846 Predicted membrane protein [Function unknown]; Region: COG4684 1033837004847 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1033837004848 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1033837004849 putative active site [active] 1033837004850 CAAX protease self-immunity; Region: Abi; pfam02517 1033837004851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033837004852 non-specific DNA binding site [nucleotide binding]; other site 1033837004853 salt bridge; other site 1033837004854 sequence-specific DNA binding site [nucleotide binding]; other site 1033837004855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033837004856 non-specific DNA binding site [nucleotide binding]; other site 1033837004857 salt bridge; other site 1033837004858 sequence-specific DNA binding site [nucleotide binding]; other site 1033837004859 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1033837004860 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1033837004861 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033837004862 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1033837004863 Walker A/P-loop; other site 1033837004864 ATP binding site [chemical binding]; other site 1033837004865 Q-loop/lid; other site 1033837004866 ABC transporter signature motif; other site 1033837004867 Walker B; other site 1033837004868 D-loop; other site 1033837004869 H-loop/switch region; other site 1033837004870 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1033837004871 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1033837004872 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1033837004873 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1033837004874 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1033837004875 FOG: CBS domain [General function prediction only]; Region: COG0517 1033837004876 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1033837004877 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1033837004878 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1033837004879 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1033837004880 acyl-activating enzyme (AAE) consensus motif; other site 1033837004881 AMP binding site [chemical binding]; other site 1033837004882 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1033837004883 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1033837004884 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1033837004885 DltD N-terminal region; Region: DltD_N; pfam04915 1033837004886 DltD central region; Region: DltD_M; pfam04918 1033837004887 DltD C-terminal region; Region: DltD_C; pfam04914 1033837004888 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1033837004889 Beta-lactamase; Region: Beta-lactamase; pfam00144 1033837004890 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1033837004891 Protein of unknown function (DUF975); Region: DUF975; cl10504 1033837004892 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 1033837004893 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1033837004894 active site 1033837004895 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837004896 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1033837004897 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1033837004898 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1033837004899 Walker A/P-loop; other site 1033837004900 ATP binding site [chemical binding]; other site 1033837004901 ABC transporter; Region: ABC_tran; pfam00005 1033837004902 Q-loop/lid; other site 1033837004903 ABC transporter signature motif; other site 1033837004904 Walker B; other site 1033837004905 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1033837004906 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1033837004907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033837004908 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1033837004909 Walker A motif; other site 1033837004910 ATP binding site [chemical binding]; other site 1033837004911 Walker B motif; other site 1033837004912 arginine finger; other site 1033837004913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033837004914 Walker A motif; other site 1033837004915 ATP binding site [chemical binding]; other site 1033837004916 Walker B motif; other site 1033837004917 arginine finger; other site 1033837004918 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1033837004919 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1033837004920 putative transport protein YifK; Provisional; Region: PRK10746 1033837004921 AAA ATPase domain; Region: AAA_16; pfam13191 1033837004922 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 1033837004923 classical (c) SDRs; Region: SDR_c; cd05233 1033837004924 NAD(P) binding site [chemical binding]; other site 1033837004925 active site 1033837004926 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 1033837004927 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 1033837004928 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1033837004929 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1033837004930 Nucleoside recognition; Region: Gate; pfam07670 1033837004931 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1033837004932 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1033837004933 Peptidase C26; Region: Peptidase_C26; pfam07722 1033837004934 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1033837004935 catalytic triad [active] 1033837004936 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1033837004937 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1033837004938 dimer interface [polypeptide binding]; other site 1033837004939 active site 1033837004940 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1033837004941 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1033837004942 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1033837004943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837004944 Walker A/P-loop; other site 1033837004945 ATP binding site [chemical binding]; other site 1033837004946 Q-loop/lid; other site 1033837004947 ABC transporter signature motif; other site 1033837004948 Walker B; other site 1033837004949 D-loop; other site 1033837004950 H-loop/switch region; other site 1033837004951 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1033837004952 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1033837004953 TM-ABC transporter signature motif; other site 1033837004954 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1033837004955 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837004956 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1033837004957 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1033837004958 active site 1033837004959 catalytic tetrad [active] 1033837004960 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1033837004961 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1033837004962 G1 box; other site 1033837004963 putative GEF interaction site [polypeptide binding]; other site 1033837004964 GTP/Mg2+ binding site [chemical binding]; other site 1033837004965 Switch I region; other site 1033837004966 G2 box; other site 1033837004967 G3 box; other site 1033837004968 Switch II region; other site 1033837004969 G4 box; other site 1033837004970 G5 box; other site 1033837004971 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1033837004972 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1033837004973 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1033837004974 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1033837004975 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1033837004976 active site 1033837004977 motif I; other site 1033837004978 motif II; other site 1033837004979 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1033837004980 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1033837004981 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1033837004982 Walker A/P-loop; other site 1033837004983 ATP binding site [chemical binding]; other site 1033837004984 Q-loop/lid; other site 1033837004985 ABC transporter signature motif; other site 1033837004986 Walker B; other site 1033837004987 D-loop; other site 1033837004988 H-loop/switch region; other site 1033837004989 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033837004990 non-specific DNA binding site [nucleotide binding]; other site 1033837004991 salt bridge; other site 1033837004992 sequence-specific DNA binding site [nucleotide binding]; other site 1033837004993 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1033837004994 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1033837004995 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1033837004996 homodimer interface [polypeptide binding]; other site 1033837004997 ligand binding site [chemical binding]; other site 1033837004998 NAD binding site [chemical binding]; other site 1033837004999 catalytic site [active] 1033837005000 MucBP domain; Region: MucBP; pfam06458 1033837005001 MucBP domain; Region: MucBP; pfam06458 1033837005002 MucBP domain; Region: MucBP; pfam06458 1033837005003 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1033837005004 active site 1033837005005 putative catalytic site [active] 1033837005006 DNA binding site [nucleotide binding] 1033837005007 putative phosphate binding site [ion binding]; other site 1033837005008 metal binding site A [ion binding]; metal-binding site 1033837005009 AP binding site [nucleotide binding]; other site 1033837005010 metal binding site B [ion binding]; metal-binding site 1033837005011 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1033837005012 PLD-like domain; Region: PLDc_2; pfam13091 1033837005013 putative homodimer interface [polypeptide binding]; other site 1033837005014 putative active site [active] 1033837005015 catalytic site [active] 1033837005016 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1033837005017 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033837005018 ATP binding site [chemical binding]; other site 1033837005019 putative Mg++ binding site [ion binding]; other site 1033837005020 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033837005021 nucleotide binding region [chemical binding]; other site 1033837005022 ATP-binding site [chemical binding]; other site 1033837005023 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1033837005024 Beta-lactamase; Region: Beta-lactamase; pfam00144 1033837005025 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1033837005026 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1033837005027 active site 1033837005028 catalytic residues [active] 1033837005029 metal binding site [ion binding]; metal-binding site 1033837005030 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1033837005031 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033837005032 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1033837005033 dimerization interface [polypeptide binding]; other site 1033837005034 FMN-binding domain; Region: FMN_bind; pfam04205 1033837005035 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1033837005036 L-aspartate oxidase; Provisional; Region: PRK06175 1033837005037 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1033837005038 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1033837005039 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1033837005040 dimerization interface [polypeptide binding]; other site 1033837005041 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1033837005042 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1033837005043 putative acyl-acceptor binding pocket; other site 1033837005044 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1033837005045 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1033837005046 Ligand binding site; other site 1033837005047 metal-binding site 1033837005048 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1033837005049 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1033837005050 Ligand binding site; other site 1033837005051 metal-binding site 1033837005052 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1033837005053 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1033837005054 active site 1033837005055 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1033837005056 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1033837005057 putative acyl-acceptor binding pocket; other site 1033837005058 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1033837005059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1033837005060 active site 1033837005061 phosphorylation site [posttranslational modification] 1033837005062 intermolecular recognition site; other site 1033837005063 dimerization interface [polypeptide binding]; other site 1033837005064 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1033837005065 DNA binding site [nucleotide binding] 1033837005066 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1033837005067 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1033837005068 dimerization interface [polypeptide binding]; other site 1033837005069 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1033837005070 putative active site [active] 1033837005071 heme pocket [chemical binding]; other site 1033837005072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1033837005073 dimer interface [polypeptide binding]; other site 1033837005074 phosphorylation site [posttranslational modification] 1033837005075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1033837005076 ATP binding site [chemical binding]; other site 1033837005077 Mg2+ binding site [ion binding]; other site 1033837005078 G-X-G motif; other site 1033837005079 YycH protein; Region: YycH; pfam07435 1033837005080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1033837005081 YycH protein; Region: YycI; pfam09648 1033837005082 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1033837005083 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1033837005084 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1033837005085 protein binding site [polypeptide binding]; other site 1033837005086 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1033837005087 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1033837005088 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033837005089 non-specific DNA binding site [nucleotide binding]; other site 1033837005090 salt bridge; other site 1033837005091 sequence-specific DNA binding site [nucleotide binding]; other site 1033837005092 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1033837005093 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1033837005094 Probable transposase; Region: OrfB_IS605; pfam01385 1033837005095 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1033837005096 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837005097 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1033837005098 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1033837005099 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1033837005100 Cobalt transport protein; Region: CbiQ; cl00463 1033837005101 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1033837005102 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1033837005103 Walker A/P-loop; other site 1033837005104 ATP binding site [chemical binding]; other site 1033837005105 Q-loop/lid; other site 1033837005106 ABC transporter signature motif; other site 1033837005107 Walker B; other site 1033837005108 D-loop; other site 1033837005109 H-loop/switch region; other site 1033837005110 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837005111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837005112 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1033837005113 Walker A/P-loop; other site 1033837005114 Walker A/P-loop; other site 1033837005115 ATP binding site [chemical binding]; other site 1033837005116 ATP binding site [chemical binding]; other site 1033837005117 Q-loop/lid; other site 1033837005118 ABC transporter signature motif; other site 1033837005119 Walker B; other site 1033837005120 D-loop; other site 1033837005121 H-loop/switch region; other site 1033837005122 Helix-turn-helix domain; Region: HTH_18; pfam12833 1033837005123 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033837005124 heat shock protein HtpX; Provisional; Region: PRK04897 1033837005125 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1033837005126 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1033837005127 transmembrane helices; other site 1033837005128 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1033837005129 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 1033837005130 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1033837005131 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1033837005132 putative active site [active] 1033837005133 catalytic site [active] 1033837005134 putative metal binding site [ion binding]; other site 1033837005135 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1033837005136 Zn2+ binding site [ion binding]; other site 1033837005137 Mg2+ binding site [ion binding]; other site 1033837005138 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1033837005139 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1033837005140 active site 1033837005141 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1033837005142 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1033837005143 Walker A/P-loop; other site 1033837005144 ATP binding site [chemical binding]; other site 1033837005145 Q-loop/lid; other site 1033837005146 ABC transporter signature motif; other site 1033837005147 Walker B; other site 1033837005148 D-loop; other site 1033837005149 H-loop/switch region; other site 1033837005150 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033837005151 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1033837005152 substrate binding pocket [chemical binding]; other site 1033837005153 membrane-bound complex binding site; other site 1033837005154 hinge residues; other site 1033837005155 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1033837005156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837005157 dimer interface [polypeptide binding]; other site 1033837005158 conserved gate region; other site 1033837005159 putative PBP binding loops; other site 1033837005160 ABC-ATPase subunit interface; other site 1033837005161 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1033837005162 active site 1033837005163 DNA binding site [nucleotide binding] 1033837005164 Protein of unknown function, DUF488; Region: DUF488; cl01246 1033837005165 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1033837005166 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1033837005167 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1033837005168 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1033837005169 DNA binding site [nucleotide binding] 1033837005170 active site 1033837005171 NAD-dependent deacetylase; Provisional; Region: PRK00481 1033837005172 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1033837005173 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 1033837005174 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1033837005175 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1033837005176 putative active site [active] 1033837005177 catalytic site [active] 1033837005178 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1033837005179 putative active site [active] 1033837005180 catalytic site [active] 1033837005181 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 1033837005182 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1033837005183 RNA/DNA hybrid binding site [nucleotide binding]; other site 1033837005184 active site 1033837005185 Predicted secreted protein [Function unknown]; Region: COG4086 1033837005186 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1033837005187 putative glycosyl transferase; Provisional; Region: PRK10073 1033837005188 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1033837005189 active site 1033837005190 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1033837005191 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1033837005192 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1033837005193 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1033837005194 CAAX protease self-immunity; Region: Abi; cl00558 1033837005195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1033837005196 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1033837005197 NAD(P) binding site [chemical binding]; other site 1033837005198 active site 1033837005199 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1033837005200 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1033837005201 Probable transposase; Region: OrfB_IS605; pfam01385 1033837005202 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1033837005203 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1033837005204 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1033837005205 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033837005206 active site 1033837005207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1033837005208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1033837005209 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1033837005210 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033837005211 substrate binding pocket [chemical binding]; other site 1033837005212 membrane-bound complex binding site; other site 1033837005213 hinge residues; other site 1033837005214 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1033837005215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837005216 dimer interface [polypeptide binding]; other site 1033837005217 conserved gate region; other site 1033837005218 putative PBP binding loops; other site 1033837005219 ABC-ATPase subunit interface; other site 1033837005220 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1033837005221 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1033837005222 Walker A/P-loop; other site 1033837005223 ATP binding site [chemical binding]; other site 1033837005224 Q-loop/lid; other site 1033837005225 ABC transporter signature motif; other site 1033837005226 Walker B; other site 1033837005227 D-loop; other site 1033837005228 H-loop/switch region; other site 1033837005229 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1033837005230 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1033837005231 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1033837005232 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1033837005233 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1033837005234 YibE/F-like protein; Region: YibE_F; pfam07907 1033837005235 YibE/F-like protein; Region: YibE_F; pfam07907 1033837005236 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1033837005237 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1033837005238 AAA domain; Region: AAA_14; pfam13173 1033837005239 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1033837005240 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1033837005241 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1033837005242 active site 1033837005243 catalytic site [active] 1033837005244 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1033837005245 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1033837005246 Interdomain contacts; other site 1033837005247 Cytokine receptor motif; other site 1033837005248 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1033837005249 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1033837005250 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1033837005251 active site 1033837005252 dimer interface [polypeptide binding]; other site 1033837005253 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1033837005254 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1033837005255 active site 1033837005256 phosphorylation site [posttranslational modification] 1033837005257 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1033837005258 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1033837005259 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1033837005260 Ligand Binding Site [chemical binding]; other site 1033837005261 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1033837005262 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1033837005263 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1033837005264 membrane-bound complex binding site; other site 1033837005265 hinge residues; other site 1033837005266 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1033837005267 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1033837005268 Walker A/P-loop; other site 1033837005269 ATP binding site [chemical binding]; other site 1033837005270 Q-loop/lid; other site 1033837005271 ABC transporter signature motif; other site 1033837005272 Walker B; other site 1033837005273 D-loop; other site 1033837005274 H-loop/switch region; other site 1033837005275 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1033837005276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837005277 dimer interface [polypeptide binding]; other site 1033837005278 conserved gate region; other site 1033837005279 putative PBP binding loops; other site 1033837005280 ABC-ATPase subunit interface; other site 1033837005281 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1033837005282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837005283 dimer interface [polypeptide binding]; other site 1033837005284 conserved gate region; other site 1033837005285 putative PBP binding loops; other site 1033837005286 ABC-ATPase subunit interface; other site 1033837005287 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1033837005288 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1033837005289 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1033837005290 active site 1033837005291 dimer interface [polypeptide binding]; other site 1033837005292 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1033837005293 Ligand Binding Site [chemical binding]; other site 1033837005294 Molecular Tunnel; other site 1033837005295 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1033837005296 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 1033837005297 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1033837005298 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1033837005299 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1033837005300 Fic family protein [Function unknown]; Region: COG3177 1033837005301 Fic/DOC family; Region: Fic; pfam02661 1033837005302 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 1033837005303 amino acid transporter; Region: 2A0306; TIGR00909 1033837005304 Spore germination protein; Region: Spore_permease; cl17796 1033837005305 Cobalt transport protein; Region: CbiQ; cl00463 1033837005306 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1033837005307 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1033837005308 Walker A/P-loop; other site 1033837005309 ATP binding site [chemical binding]; other site 1033837005310 Q-loop/lid; other site 1033837005311 ABC transporter signature motif; other site 1033837005312 Walker B; other site 1033837005313 D-loop; other site 1033837005314 H-loop/switch region; other site 1033837005315 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1033837005316 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1033837005317 Walker A/P-loop; other site 1033837005318 ATP binding site [chemical binding]; other site 1033837005319 Q-loop/lid; other site 1033837005320 ABC transporter signature motif; other site 1033837005321 Walker B; other site 1033837005322 D-loop; other site 1033837005323 H-loop/switch region; other site 1033837005324 Helix-turn-helix domain; Region: HTH_38; pfam13936 1033837005325 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1033837005326 Integrase core domain; Region: rve; pfam00665 1033837005327 Integrase core domain; Region: rve_3; cl15866 1033837005328 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1033837005329 Helix-turn-helix domain; Region: HTH_38; pfam13936 1033837005330 Small integral membrane protein [Function unknown]; Region: COG5547 1033837005331 FRG domain; Region: FRG; cl07460 1033837005332 FRG domain; Region: FRG; cl07460 1033837005333 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1033837005334 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1033837005335 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1033837005336 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1033837005337 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1033837005338 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1033837005339 MULE transposase domain; Region: MULE; pfam10551 1033837005340 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1033837005341 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1033837005342 N-glycosyltransferase; Provisional; Region: PRK11204 1033837005343 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1033837005344 DXD motif; other site 1033837005345 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1033837005346 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1033837005347 Helix-turn-helix domain; Region: HTH_38; pfam13936 1033837005348 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 1033837005349 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1033837005350 conserved cys residue [active] 1033837005351 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1033837005352 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1033837005353 catalytic residues [active] 1033837005354 catalytic nucleophile [active] 1033837005355 Presynaptic Site I dimer interface [polypeptide binding]; other site 1033837005356 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1033837005357 Synaptic Flat tetramer interface [polypeptide binding]; other site 1033837005358 Synaptic Site I dimer interface [polypeptide binding]; other site 1033837005359 DNA binding site [nucleotide binding] 1033837005360 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1033837005361 DNA-binding interface [nucleotide binding]; DNA binding site 1033837005362 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1033837005363 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1033837005364 Helix-turn-helix domain; Region: HTH_38; pfam13936 1033837005365 Integrase core domain; Region: rve; pfam00665 1033837005366 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1033837005367 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1033837005368 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1033837005369 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1033837005370 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1033837005371 dimer interface [polypeptide binding]; other site 1033837005372 putative radical transfer pathway; other site 1033837005373 diiron center [ion binding]; other site 1033837005374 tyrosyl radical; other site 1033837005375 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1033837005376 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 1033837005377 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1033837005378 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1033837005379 active site 1033837005380 dimer interface [polypeptide binding]; other site 1033837005381 catalytic residues [active] 1033837005382 effector binding site; other site 1033837005383 R2 peptide binding site; other site 1033837005384 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1033837005385 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1033837005386 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1033837005387 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1033837005388 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1033837005389 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1033837005390 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1033837005391 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1033837005392 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1033837005393 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1033837005394 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1033837005395 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1033837005396 MarR family; Region: MarR_2; pfam12802 1033837005397 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1033837005398 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1033837005399 dimer interface [polypeptide binding]; other site 1033837005400 active site 1033837005401 CoA binding pocket [chemical binding]; other site 1033837005402 acyl carrier protein; Provisional; Region: acpP; PRK00982 1033837005403 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1033837005404 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1033837005405 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1033837005406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1033837005407 NAD(P) binding site [chemical binding]; other site 1033837005408 active site 1033837005409 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1033837005410 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1033837005411 dimer interface [polypeptide binding]; other site 1033837005412 active site 1033837005413 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1033837005414 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1033837005415 carboxyltransferase (CT) interaction site; other site 1033837005416 biotinylation site [posttranslational modification]; other site 1033837005417 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1033837005418 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1033837005419 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1033837005420 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1033837005421 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1033837005422 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1033837005423 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1033837005424 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1033837005425 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 1033837005426 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1033837005427 NAD binding site [chemical binding]; other site 1033837005428 homotetramer interface [polypeptide binding]; other site 1033837005429 homodimer interface [polypeptide binding]; other site 1033837005430 substrate binding site [chemical binding]; other site 1033837005431 active site 1033837005432 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1033837005433 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1033837005434 putative DNA binding site [nucleotide binding]; other site 1033837005435 putative Zn2+ binding site [ion binding]; other site 1033837005436 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1033837005437 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1033837005438 BioY family; Region: BioY; pfam02632 1033837005439 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1033837005440 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1033837005441 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1033837005442 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1033837005443 dimerization interface [polypeptide binding]; other site 1033837005444 active site 1033837005445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033837005446 benzoate transport; Region: 2A0115; TIGR00895 1033837005447 putative substrate translocation pore; other site 1033837005448 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1033837005449 Helix-turn-helix domain; Region: HTH_38; pfam13936 1033837005450 Integrase core domain; Region: rve; pfam00665 1033837005451 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1033837005452 Helix-turn-helix domain; Region: HTH_38; pfam13936 1033837005453 Integrase core domain; Region: rve; pfam00665 1033837005454 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1033837005455 FAD binding site [chemical binding]; other site 1033837005456 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1033837005457 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1033837005458 THF binding site; other site 1033837005459 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1033837005460 substrate binding site [chemical binding]; other site 1033837005461 THF binding site; other site 1033837005462 zinc-binding site [ion binding]; other site 1033837005463 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1033837005464 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1033837005465 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1033837005466 ATP cone domain; Region: ATP-cone; pfam03477 1033837005467 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1033837005468 effector binding site; other site 1033837005469 active site 1033837005470 Zn binding site [ion binding]; other site 1033837005471 glycine loop; other site 1033837005472 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1033837005473 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1033837005474 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1033837005475 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 1033837005476 Uncharacterized conserved protein [Function unknown]; Region: COG2461 1033837005477 Family of unknown function (DUF438); Region: DUF438; pfam04282 1033837005478 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1033837005479 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1033837005480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1033837005481 putative substrate translocation pore; other site 1033837005482 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1033837005483 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1033837005484 active site 1033837005485 Zn binding site [ion binding]; other site 1033837005486 K+ potassium transporter; Region: K_trans; pfam02705 1033837005487 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1033837005488 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837005489 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1033837005490 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1033837005491 DNA binding residues [nucleotide binding] 1033837005492 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1033837005493 catalytic residues [active] 1033837005494 catalytic nucleophile [active] 1033837005495 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1033837005496 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837005497 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1033837005498 amidase catalytic site [active] 1033837005499 Zn binding residues [ion binding]; other site 1033837005500 substrate binding site [chemical binding]; other site 1033837005501 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837005502 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1033837005503 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1033837005504 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1033837005505 TrkA-N domain; Region: TrkA_N; pfam02254 1033837005506 TrkA-C domain; Region: TrkA_C; pfam02080 1033837005507 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1033837005508 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1033837005509 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1033837005510 catalytic core [active] 1033837005511 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1033837005512 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1033837005513 putative substrate binding pocket [chemical binding]; other site 1033837005514 AC domain interface; other site 1033837005515 catalytic triad [active] 1033837005516 AB domain interface; other site 1033837005517 interchain disulfide; other site 1033837005518 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1033837005519 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1033837005520 Sulfatase; Region: Sulfatase; cl17466 1033837005521 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1033837005522 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1033837005523 active site 1033837005524 HIGH motif; other site 1033837005525 dimer interface [polypeptide binding]; other site 1033837005526 KMSKS motif; other site 1033837005527 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1033837005528 RNA binding surface [nucleotide binding]; other site 1033837005529 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1033837005530 trimer interface [polypeptide binding]; other site 1033837005531 active site 1033837005532 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1033837005533 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1033837005534 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1033837005535 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1033837005536 peptide binding site [polypeptide binding]; other site 1033837005537 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1033837005538 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1033837005539 peptide binding site [polypeptide binding]; other site 1033837005540 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 1033837005541 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1033837005542 active site 1033837005543 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1033837005544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837005545 dimer interface [polypeptide binding]; other site 1033837005546 conserved gate region; other site 1033837005547 putative PBP binding loops; other site 1033837005548 ABC-ATPase subunit interface; other site 1033837005549 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1033837005550 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1033837005551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1033837005552 dimer interface [polypeptide binding]; other site 1033837005553 conserved gate region; other site 1033837005554 putative PBP binding loops; other site 1033837005555 ABC-ATPase subunit interface; other site 1033837005556 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1033837005557 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033837005558 Walker A/P-loop; other site 1033837005559 ATP binding site [chemical binding]; other site 1033837005560 Q-loop/lid; other site 1033837005561 ABC transporter signature motif; other site 1033837005562 Walker B; other site 1033837005563 D-loop; other site 1033837005564 H-loop/switch region; other site 1033837005565 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1033837005566 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1033837005567 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1033837005568 Walker A/P-loop; other site 1033837005569 ATP binding site [chemical binding]; other site 1033837005570 Q-loop/lid; other site 1033837005571 ABC transporter signature motif; other site 1033837005572 Walker B; other site 1033837005573 D-loop; other site 1033837005574 H-loop/switch region; other site 1033837005575 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1033837005576 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1033837005577 trimer interface [polypeptide binding]; other site 1033837005578 active site 1033837005579 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1033837005580 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1033837005581 putative dimer interface [polypeptide binding]; other site 1033837005582 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1033837005583 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1033837005584 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1033837005585 CAAX protease self-immunity; Region: Abi; pfam02517 1033837005586 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1033837005587 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1033837005588 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1033837005589 active site 1033837005590 HIGH motif; other site 1033837005591 dimer interface [polypeptide binding]; other site 1033837005592 KMSKS motif; other site 1033837005593 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1033837005594 catalytic motif [active] 1033837005595 Zn binding site [ion binding]; other site 1033837005596 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1033837005597 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1033837005598 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1033837005599 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1033837005600 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1033837005601 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1033837005602 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1033837005603 active site 1033837005604 HIGH motif; other site 1033837005605 KMSKS motif; other site 1033837005606 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1033837005607 tRNA binding surface [nucleotide binding]; other site 1033837005608 anticodon binding site; other site 1033837005609 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1033837005610 dimer interface [polypeptide binding]; other site 1033837005611 putative tRNA-binding site [nucleotide binding]; other site 1033837005612 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1033837005613 active site 1033837005614 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1033837005615 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1033837005616 putative active site [active] 1033837005617 putative metal binding site [ion binding]; other site 1033837005618 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1033837005619 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1033837005620 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1033837005621 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1033837005622 pur operon repressor; Provisional; Region: PRK09213 1033837005623 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1033837005624 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033837005625 active site 1033837005626 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1033837005627 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1033837005628 Substrate binding site; other site 1033837005629 Mg++ binding site; other site 1033837005630 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1033837005631 active site 1033837005632 substrate binding site [chemical binding]; other site 1033837005633 CoA binding site [chemical binding]; other site 1033837005634 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837005635 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837005636 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837005637 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837005638 Bacterial surface layer protein; Region: SLAP; pfam03217 1033837005639 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1033837005640 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1033837005641 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033837005642 active site 1033837005643 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1033837005644 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1033837005645 nucleotide binding site [chemical binding]; other site 1033837005646 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1033837005647 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1033837005648 Zn2+ binding site [ion binding]; other site 1033837005649 Mg2+ binding site [ion binding]; other site 1033837005650 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1033837005651 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1033837005652 CTP synthetase; Validated; Region: pyrG; PRK05380 1033837005653 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1033837005654 Catalytic site [active] 1033837005655 active site 1033837005656 UTP binding site [chemical binding]; other site 1033837005657 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1033837005658 active site 1033837005659 putative oxyanion hole; other site 1033837005660 catalytic triad [active] 1033837005661 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1033837005662 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1033837005663 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1033837005664 hinge; other site 1033837005665 active site 1033837005666 Peptidase family C69; Region: Peptidase_C69; pfam03577 1033837005667 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1033837005668 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1033837005669 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1033837005670 xanthine permease; Region: pbuX; TIGR03173 1033837005671 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1033837005672 active site 1033837005673 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1033837005674 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1033837005675 non-specific DNA binding site [nucleotide binding]; other site 1033837005676 salt bridge; other site 1033837005677 sequence-specific DNA binding site [nucleotide binding]; other site 1033837005678 GMP synthase; Reviewed; Region: guaA; PRK00074 1033837005679 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1033837005680 AMP/PPi binding site [chemical binding]; other site 1033837005681 candidate oxyanion hole; other site 1033837005682 catalytic triad [active] 1033837005683 potential glutamine specificity residues [chemical binding]; other site 1033837005684 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1033837005685 ATP Binding subdomain [chemical binding]; other site 1033837005686 Ligand Binding sites [chemical binding]; other site 1033837005687 Dimerization subdomain; other site 1033837005688 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1033837005689 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1033837005690 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1033837005691 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033837005692 ATP binding site [chemical binding]; other site 1033837005693 putative Mg++ binding site [ion binding]; other site 1033837005694 T5orf172 domain; Region: T5orf172; pfam10544 1033837005695 Fic family protein [Function unknown]; Region: COG3177 1033837005696 Fic/DOC family; Region: Fic; pfam02661 1033837005697 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1033837005698 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1033837005699 dimer interface [polypeptide binding]; other site 1033837005700 active site 1033837005701 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1033837005702 folate binding site [chemical binding]; other site 1033837005703 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1033837005704 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1033837005705 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1033837005706 active site 1033837005707 motif I; other site 1033837005708 motif II; other site 1033837005709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1033837005710 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1033837005711 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1033837005712 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1033837005713 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1033837005714 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1033837005715 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1033837005716 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1033837005717 ATP binding site [chemical binding]; other site 1033837005718 Mg++ binding site [ion binding]; other site 1033837005719 motif III; other site 1033837005720 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033837005721 nucleotide binding region [chemical binding]; other site 1033837005722 ATP-binding site [chemical binding]; other site 1033837005723 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1033837005724 alanine racemase; Reviewed; Region: alr; PRK00053 1033837005725 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1033837005726 active site 1033837005727 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1033837005728 dimer interface [polypeptide binding]; other site 1033837005729 substrate binding site [chemical binding]; other site 1033837005730 catalytic residues [active] 1033837005731 FOG: CBS domain [General function prediction only]; Region: COG0517 1033837005732 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1033837005733 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1033837005734 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1033837005735 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1033837005736 NAD binding site [chemical binding]; other site 1033837005737 dimer interface [polypeptide binding]; other site 1033837005738 substrate binding site [chemical binding]; other site 1033837005739 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1033837005740 putative active site [active] 1033837005741 catalytic residue [active] 1033837005742 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1033837005743 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1033837005744 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1033837005745 ATP binding site [chemical binding]; other site 1033837005746 putative Mg++ binding site [ion binding]; other site 1033837005747 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1033837005748 nucleotide binding region [chemical binding]; other site 1033837005749 ATP-binding site [chemical binding]; other site 1033837005750 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1033837005751 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1033837005752 RNA binding surface [nucleotide binding]; other site 1033837005753 Septum formation initiator; Region: DivIC; pfam04977 1033837005754 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1033837005755 RNA binding site [nucleotide binding]; other site 1033837005756 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1033837005757 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1033837005758 Ligand Binding Site [chemical binding]; other site 1033837005759 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1033837005760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033837005761 Walker A motif; other site 1033837005762 ATP binding site [chemical binding]; other site 1033837005763 Walker B motif; other site 1033837005764 arginine finger; other site 1033837005765 Peptidase family M41; Region: Peptidase_M41; pfam01434 1033837005766 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1033837005767 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1033837005768 dimerization interface [polypeptide binding]; other site 1033837005769 domain crossover interface; other site 1033837005770 redox-dependent activation switch; other site 1033837005771 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1033837005772 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1033837005773 FMN binding site [chemical binding]; other site 1033837005774 active site 1033837005775 catalytic residues [active] 1033837005776 substrate binding site [chemical binding]; other site 1033837005777 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1033837005778 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1033837005779 dimer interface [polypeptide binding]; other site 1033837005780 putative anticodon binding site; other site 1033837005781 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1033837005782 motif 1; other site 1033837005783 active site 1033837005784 motif 2; other site 1033837005785 motif 3; other site 1033837005786 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1033837005787 GAF domain; Region: GAF_2; pfam13185 1033837005788 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1033837005789 Clp amino terminal domain; Region: Clp_N; pfam02861 1033837005790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033837005791 Walker A motif; other site 1033837005792 ATP binding site [chemical binding]; other site 1033837005793 Walker B motif; other site 1033837005794 arginine finger; other site 1033837005795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1033837005796 Walker A motif; other site 1033837005797 ATP binding site [chemical binding]; other site 1033837005798 Walker B motif; other site 1033837005799 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1033837005800 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1033837005801 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1033837005802 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1033837005803 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1033837005804 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1033837005805 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1033837005806 RPB10 interaction site [polypeptide binding]; other site 1033837005807 RPB1 interaction site [polypeptide binding]; other site 1033837005808 RPB11 interaction site [polypeptide binding]; other site 1033837005809 RPB3 interaction site [polypeptide binding]; other site 1033837005810 RPB12 interaction site [polypeptide binding]; other site 1033837005811 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1033837005812 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1033837005813 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1033837005814 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1033837005815 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1033837005816 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1033837005817 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1033837005818 G-loop; other site 1033837005819 DNA binding site [nucleotide binding] 1033837005820 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1033837005821 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1033837005822 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1033837005823 S17 interaction site [polypeptide binding]; other site 1033837005824 S8 interaction site; other site 1033837005825 16S rRNA interaction site [nucleotide binding]; other site 1033837005826 streptomycin interaction site [chemical binding]; other site 1033837005827 23S rRNA interaction site [nucleotide binding]; other site 1033837005828 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1033837005829 30S ribosomal protein S7; Validated; Region: PRK05302 1033837005830 elongation factor G; Reviewed; Region: PRK12739 1033837005831 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1033837005832 G1 box; other site 1033837005833 putative GEF interaction site [polypeptide binding]; other site 1033837005834 GTP/Mg2+ binding site [chemical binding]; other site 1033837005835 Switch I region; other site 1033837005836 G2 box; other site 1033837005837 G3 box; other site 1033837005838 Switch II region; other site 1033837005839 G4 box; other site 1033837005840 G5 box; other site 1033837005841 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1033837005842 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1033837005843 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1033837005844 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1033837005845 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1033837005846 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1033837005847 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1033837005848 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1033837005849 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1033837005850 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1033837005851 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1033837005852 MobA/MobL family; Region: MobA_MobL; pfam03389 1033837005853 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 1033837005854 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1033837005855 AAA-like domain; Region: AAA_10; pfam12846 1033837005856 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1033837005857 G1 box; other site 1033837005858 GTP/Mg2+ binding site [chemical binding]; other site 1033837005859 Switch I region; other site 1033837005860 NlpC/P60 family; Region: NLPC_P60; cl17555 1033837005861 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 1033837005862 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1033837005863 catalytic residues [active] 1033837005864 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 1033837005865 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1033837005866 Walker A motif; other site 1033837005867 ATP binding site [chemical binding]; other site 1033837005868 Walker B motif; other site 1033837005869 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1033837005870 DNA topoisomerase III; Provisional; Region: PRK07726 1033837005871 active site 1033837005872 putative interdomain interaction site [polypeptide binding]; other site 1033837005873 putative metal-binding site [ion binding]; other site 1033837005874 putative nucleotide binding site [chemical binding]; other site 1033837005875 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1033837005876 domain I; other site 1033837005877 DNA binding groove [nucleotide binding] 1033837005878 phosphate binding site [ion binding]; other site 1033837005879 domain II; other site 1033837005880 domain III; other site 1033837005881 nucleotide binding site [chemical binding]; other site 1033837005882 catalytic site [active] 1033837005883 domain IV; other site 1033837005884 Domain of unknown function (DUF955); Region: DUF955; cl01076 1033837005885 Domain of unknown function DUF87; Region: DUF87; pfam01935 1033837005886 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1033837005887 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1033837005888 DNA methylase; Region: N6_N4_Mtase; cl17433 1033837005889 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1033837005890 catalytic nucleophile [active] 1033837005891 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1033837005892 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1033837005893 catalytic residues [active] 1033837005894 catalytic nucleophile [active] 1033837005895 Presynaptic Site I dimer interface [polypeptide binding]; other site 1033837005896 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1033837005897 Synaptic Flat tetramer interface [polypeptide binding]; other site 1033837005898 Synaptic Site I dimer interface [polypeptide binding]; other site 1033837005899 DNA binding site [nucleotide binding] 1033837005900 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1033837005901 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1033837005902 active site 1033837005903 ATP binding site [chemical binding]; other site 1033837005904 substrate binding site [chemical binding]; other site 1033837005905 activation loop (A-loop); other site 1033837005906 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1033837005907 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1033837005908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1033837005909 Walker A/P-loop; other site 1033837005910 ATP binding site [chemical binding]; other site 1033837005911 Q-loop/lid; other site 1033837005912 ABC transporter signature motif; other site 1033837005913 Walker B; other site 1033837005914 D-loop; other site 1033837005915 H-loop/switch region; other site 1033837005916 plasmid segregation protein ParM; Provisional; Region: PRK13917 1033837005917 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1033837005918 Mg binding site [ion binding]; other site 1033837005919 nucleotide binding site [chemical binding]; other site 1033837005920 putative protofilament interface [polypeptide binding]; other site 1033837005921 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 1033837005922 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1033837005923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1033837005924 S-adenosylmethionine binding site [chemical binding]; other site 1033837005925 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1033837005926 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1033837005927 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1033837005928 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1033837005929 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1033837005930 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1033837005931 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1033837005932 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1033837005933 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1033837005934 amphipathic channel; other site 1033837005935 Asn-Pro-Ala signature motifs; other site 1033837005936 RelB antitoxin; Region: RelB; cl01171 1033837005937 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958