-- dump date 20140619_123950 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1327988000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1327988000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1327988000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988000004 Walker A motif; other site 1327988000005 ATP binding site [chemical binding]; other site 1327988000006 Walker B motif; other site 1327988000007 arginine finger; other site 1327988000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1327988000009 DnaA box-binding interface [nucleotide binding]; other site 1327988000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1327988000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1327988000012 putative DNA binding surface [nucleotide binding]; other site 1327988000013 dimer interface [polypeptide binding]; other site 1327988000014 beta-clamp/clamp loader binding surface; other site 1327988000015 beta-clamp/translesion DNA polymerase binding surface; other site 1327988000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1327988000017 recombination protein F; Reviewed; Region: recF; PRK00064 1327988000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1327988000019 Walker A/P-loop; other site 1327988000020 ATP binding site [chemical binding]; other site 1327988000021 Q-loop/lid; other site 1327988000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988000023 ABC transporter signature motif; other site 1327988000024 Walker B; other site 1327988000025 D-loop; other site 1327988000026 H-loop/switch region; other site 1327988000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1327988000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1327988000029 Mg2+ binding site [ion binding]; other site 1327988000030 G-X-G motif; other site 1327988000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1327988000032 anchoring element; other site 1327988000033 dimer interface [polypeptide binding]; other site 1327988000034 ATP binding site [chemical binding]; other site 1327988000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1327988000036 active site 1327988000037 putative metal-binding site [ion binding]; other site 1327988000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1327988000039 DNA gyrase subunit A; Validated; Region: PRK05560 1327988000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1327988000041 CAP-like domain; other site 1327988000042 active site 1327988000043 primary dimer interface [polypeptide binding]; other site 1327988000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1327988000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1327988000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1327988000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1327988000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1327988000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1327988000050 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1327988000051 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1327988000052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1327988000053 dimer interface [polypeptide binding]; other site 1327988000054 ssDNA binding site [nucleotide binding]; other site 1327988000055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1327988000056 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1327988000057 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1327988000058 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1327988000059 metal binding site [ion binding]; metal-binding site 1327988000060 DHH family; Region: DHH; pfam01368 1327988000061 DHHA1 domain; Region: DHHA1; pfam02272 1327988000062 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1327988000063 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1327988000064 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1327988000065 replicative DNA helicase; Provisional; Region: PRK05748 1327988000066 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1327988000067 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1327988000068 Walker A motif; other site 1327988000069 ATP binding site [chemical binding]; other site 1327988000070 Walker B motif; other site 1327988000071 DNA binding loops [nucleotide binding] 1327988000072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988000073 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988000074 putative substrate translocation pore; other site 1327988000075 gamma-glutamyl kinase; Provisional; Region: PRK05429 1327988000076 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1327988000077 nucleotide binding site [chemical binding]; other site 1327988000078 homotetrameric interface [polypeptide binding]; other site 1327988000079 putative phosphate binding site [ion binding]; other site 1327988000080 putative allosteric binding site; other site 1327988000081 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1327988000082 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1327988000083 putative catalytic cysteine [active] 1327988000084 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1327988000085 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1327988000086 peptide binding site [polypeptide binding]; other site 1327988000087 glycogen branching enzyme; Provisional; Region: PRK12313 1327988000088 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1327988000089 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1327988000090 active site 1327988000091 catalytic site [active] 1327988000092 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1327988000093 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1327988000094 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1327988000095 ligand binding site; other site 1327988000096 oligomer interface; other site 1327988000097 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1327988000098 dimer interface [polypeptide binding]; other site 1327988000099 N-terminal domain interface [polypeptide binding]; other site 1327988000100 sulfate 1 binding site; other site 1327988000101 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1327988000102 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1327988000103 ligand binding site; other site 1327988000104 oligomer interface; other site 1327988000105 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1327988000106 dimer interface [polypeptide binding]; other site 1327988000107 N-terminal domain interface [polypeptide binding]; other site 1327988000108 sulfate 1 binding site; other site 1327988000109 glycogen synthase; Provisional; Region: glgA; PRK00654 1327988000110 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1327988000111 ADP-binding pocket [chemical binding]; other site 1327988000112 homodimer interface [polypeptide binding]; other site 1327988000113 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1327988000114 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1327988000115 active site pocket [active] 1327988000116 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1327988000117 active site 1327988000118 homodimer interface [polypeptide binding]; other site 1327988000119 catalytic site [active] 1327988000120 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1327988000121 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988000122 active site 1327988000123 motif I; other site 1327988000124 motif II; other site 1327988000125 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1327988000126 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1327988000127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988000128 motif II; other site 1327988000129 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1327988000130 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1327988000131 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1327988000132 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1327988000133 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1327988000134 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1327988000135 DNA-binding site [nucleotide binding]; DNA binding site 1327988000136 RNA-binding motif; other site 1327988000137 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1327988000138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1327988000139 active site 1327988000140 phosphorylation site [posttranslational modification] 1327988000141 intermolecular recognition site; other site 1327988000142 dimerization interface [polypeptide binding]; other site 1327988000143 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1327988000144 DNA binding site [nucleotide binding] 1327988000145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1327988000146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1327988000147 dimerization interface [polypeptide binding]; other site 1327988000148 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1327988000149 putative active site [active] 1327988000150 heme pocket [chemical binding]; other site 1327988000151 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1327988000152 dimer interface [polypeptide binding]; other site 1327988000153 phosphorylation site [posttranslational modification] 1327988000154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1327988000155 ATP binding site [chemical binding]; other site 1327988000156 Mg2+ binding site [ion binding]; other site 1327988000157 G-X-G motif; other site 1327988000158 YycH protein; Region: YycH; pfam07435 1327988000159 YycH protein; Region: YycI; pfam09648 1327988000160 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1327988000161 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1327988000162 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1327988000163 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1327988000164 protein binding site [polypeptide binding]; other site 1327988000165 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1327988000166 Replication initiation factor; Region: Rep_trans; pfam02486 1327988000167 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1327988000168 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1327988000169 catalytic residues [active] 1327988000170 catalytic nucleophile [active] 1327988000171 Recombinase; Region: Recombinase; pfam07508 1327988000172 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1327988000173 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1327988000174 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1327988000175 catalytic residues [active] 1327988000176 catalytic nucleophile [active] 1327988000177 Recombinase; Region: Recombinase; pfam07508 1327988000178 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1327988000179 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1327988000180 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1327988000181 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1327988000182 ATP binding site [chemical binding]; other site 1327988000183 putative Mg++ binding site [ion binding]; other site 1327988000184 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 1327988000185 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1327988000186 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1327988000187 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1327988000188 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1327988000189 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1327988000190 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1327988000191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988000192 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1327988000193 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1327988000194 NAD(P) binding site [chemical binding]; other site 1327988000195 catalytic residues [active] 1327988000196 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1327988000197 Uncharacterized conserved protein [Function unknown]; Region: COG3586 1327988000198 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1327988000199 putative uracil binding site [chemical binding]; other site 1327988000200 putative active site [active] 1327988000201 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1327988000202 putative FMN binding site [chemical binding]; other site 1327988000203 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 1327988000204 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1327988000205 Predicted flavoprotein [General function prediction only]; Region: COG0431 1327988000206 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1327988000207 FAD binding domain; Region: FAD_binding_2; pfam00890 1327988000208 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1327988000209 FMN-binding domain; Region: FMN_bind; cl01081 1327988000210 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1327988000211 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1327988000212 transmembrane helices; other site 1327988000213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988000214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1327988000215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1327988000216 dimerization interface [polypeptide binding]; other site 1327988000217 flavodoxin; Provisional; Region: PRK06242 1327988000218 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1327988000219 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1327988000220 active site 1327988000221 hypothetical protein; Provisional; Region: PRK06194 1327988000222 classical (c) SDRs; Region: SDR_c; cd05233 1327988000223 NAD(P) binding site [chemical binding]; other site 1327988000224 active site 1327988000225 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1327988000226 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1327988000227 dimer interface [polypeptide binding]; other site 1327988000228 FMN binding site [chemical binding]; other site 1327988000229 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1327988000230 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1327988000231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988000232 motif II; other site 1327988000233 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1327988000234 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1327988000235 active site 1327988000236 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1327988000237 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1327988000238 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1327988000239 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1327988000240 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1327988000241 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1327988000242 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1327988000243 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1327988000244 catalytic triad [active] 1327988000245 Predicted transcriptional regulator [Transcription]; Region: COG2378 1327988000246 HTH domain; Region: HTH_11; pfam08279 1327988000247 WYL domain; Region: WYL; pfam13280 1327988000248 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1327988000249 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1327988000250 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1327988000251 G1 box; other site 1327988000252 putative GEF interaction site [polypeptide binding]; other site 1327988000253 GTP/Mg2+ binding site [chemical binding]; other site 1327988000254 Switch I region; other site 1327988000255 G2 box; other site 1327988000256 G3 box; other site 1327988000257 Switch II region; other site 1327988000258 G4 box; other site 1327988000259 G5 box; other site 1327988000260 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1327988000261 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 1327988000262 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1327988000263 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 1327988000264 Protein of unknown function; Region: DUF3658; pfam12395 1327988000265 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1327988000266 EamA-like transporter family; Region: EamA; pfam00892 1327988000267 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1327988000268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1327988000269 Coenzyme A binding pocket [chemical binding]; other site 1327988000270 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1327988000271 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1327988000272 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1327988000273 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1327988000274 putative NAD(P) binding site [chemical binding]; other site 1327988000275 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1327988000276 dimerization interface [polypeptide binding]; other site 1327988000277 putative DNA binding site [nucleotide binding]; other site 1327988000278 putative Zn2+ binding site [ion binding]; other site 1327988000279 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1327988000280 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1327988000281 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1327988000282 hypothetical protein; Validated; Region: PRK02101 1327988000283 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1327988000284 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1327988000285 peptide binding site [polypeptide binding]; other site 1327988000286 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1327988000287 active site 1327988000288 NTP binding site [chemical binding]; other site 1327988000289 metal binding triad [ion binding]; metal-binding site 1327988000290 antibiotic binding site [chemical binding]; other site 1327988000291 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1327988000292 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1327988000293 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1327988000294 Walker A/P-loop; other site 1327988000295 ATP binding site [chemical binding]; other site 1327988000296 Q-loop/lid; other site 1327988000297 ABC transporter signature motif; other site 1327988000298 Walker B; other site 1327988000299 D-loop; other site 1327988000300 H-loop/switch region; other site 1327988000301 Cobalt transport protein; Region: CbiQ; cl00463 1327988000302 cobalt transport protein CbiM; Provisional; Region: PRK07331 1327988000303 cobalt transport protein CbiM; Provisional; Region: PRK11909 1327988000304 PDGLE domain; Region: PDGLE; pfam13190 1327988000305 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1327988000306 putative switch regulator; other site 1327988000307 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1327988000308 non-specific DNA interactions [nucleotide binding]; other site 1327988000309 DNA binding site [nucleotide binding] 1327988000310 sequence specific DNA binding site [nucleotide binding]; other site 1327988000311 putative cAMP binding site [chemical binding]; other site 1327988000312 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 1327988000313 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1327988000314 AIR carboxylase; Region: AIRC; smart01001 1327988000315 Protein of unknown function DUF111; Region: DUF111; cl03398 1327988000316 Protein of unknown function DUF111; Region: DUF111; cl03398 1327988000317 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1327988000318 amphipathic channel; other site 1327988000319 Asn-Pro-Ala signature motifs; other site 1327988000320 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 1327988000321 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1327988000322 Ligand Binding Site [chemical binding]; other site 1327988000323 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 1327988000324 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1327988000325 putative NAD(P) binding site [chemical binding]; other site 1327988000326 substrate binding site [chemical binding]; other site 1327988000327 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1327988000328 substrate binding site [chemical binding]; other site 1327988000329 multimerization interface [polypeptide binding]; other site 1327988000330 ATP binding site [chemical binding]; other site 1327988000331 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1327988000332 dimer interface [polypeptide binding]; other site 1327988000333 substrate binding site [chemical binding]; other site 1327988000334 ATP binding site [chemical binding]; other site 1327988000335 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1327988000336 thiamine phosphate binding site [chemical binding]; other site 1327988000337 active site 1327988000338 pyrophosphate binding site [ion binding]; other site 1327988000339 putative hydroxymethylpyrimidine transporter CytX; Region: thia_cytX; TIGR02358 1327988000340 Na binding site [ion binding]; other site 1327988000341 Peptidase C26; Region: Peptidase_C26; pfam07722 1327988000342 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1327988000343 catalytic triad [active] 1327988000344 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 1327988000345 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1327988000346 nudix motif; other site 1327988000347 putative transport protein YifK; Provisional; Region: PRK10746 1327988000348 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1327988000349 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1327988000350 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1327988000351 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1327988000352 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1327988000353 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1327988000354 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1327988000355 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1327988000356 PspC domain; Region: PspC; pfam04024 1327988000357 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1327988000358 Predicted flavoprotein [General function prediction only]; Region: COG0431 1327988000359 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1327988000360 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1327988000361 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1327988000362 putative dimer interface [polypeptide binding]; other site 1327988000363 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1327988000364 drug efflux system protein MdtG; Provisional; Region: PRK09874 1327988000365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988000366 putative substrate translocation pore; other site 1327988000367 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1327988000368 dimerization interface [polypeptide binding]; other site 1327988000369 putative DNA binding site [nucleotide binding]; other site 1327988000370 putative Zn2+ binding site [ion binding]; other site 1327988000371 cyanate transporter; Region: CynX; TIGR00896 1327988000372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988000373 putative substrate translocation pore; other site 1327988000374 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1327988000375 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1327988000376 active site 1327988000377 catalytic tetrad [active] 1327988000378 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1327988000379 catalytic tetrad [active] 1327988000380 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1327988000381 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1327988000382 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1327988000383 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1327988000384 putative active site [active] 1327988000385 putative FMN binding site [chemical binding]; other site 1327988000386 putative substrate binding site [chemical binding]; other site 1327988000387 putative catalytic residue [active] 1327988000388 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1327988000389 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1327988000390 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1327988000391 Walker A/P-loop; other site 1327988000392 ATP binding site [chemical binding]; other site 1327988000393 Q-loop/lid; other site 1327988000394 ABC transporter signature motif; other site 1327988000395 Walker B; other site 1327988000396 D-loop; other site 1327988000397 H-loop/switch region; other site 1327988000398 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1327988000399 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1327988000400 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1327988000401 Walker A/P-loop; other site 1327988000402 ATP binding site [chemical binding]; other site 1327988000403 Q-loop/lid; other site 1327988000404 ABC transporter signature motif; other site 1327988000405 Walker B; other site 1327988000406 D-loop; other site 1327988000407 H-loop/switch region; other site 1327988000408 hypothetical protein; Provisional; Region: PRK13661 1327988000409 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1327988000410 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1327988000411 DNA-binding site [nucleotide binding]; DNA binding site 1327988000412 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1327988000413 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1327988000414 classical (c) SDRs; Region: SDR_c; cd05233 1327988000415 NAD(P) binding site [chemical binding]; other site 1327988000416 active site 1327988000417 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1327988000418 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1327988000419 Walker A/P-loop; other site 1327988000420 ATP binding site [chemical binding]; other site 1327988000421 Q-loop/lid; other site 1327988000422 ABC transporter signature motif; other site 1327988000423 Walker B; other site 1327988000424 D-loop; other site 1327988000425 H-loop/switch region; other site 1327988000426 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1327988000427 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1327988000428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988000429 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988000430 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1327988000431 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1327988000432 active site 1327988000433 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1327988000434 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1327988000435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988000436 probable dihydroxyacetone kinase DhaK1b subunit; Region: dhaK1b; TIGR02362 1327988000437 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1327988000438 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1327988000439 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1327988000440 DAK2 domain; Region: Dak2; cl03685 1327988000441 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1327988000442 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1327988000443 amphipathic channel; other site 1327988000444 Asn-Pro-Ala signature motifs; other site 1327988000445 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1327988000446 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1327988000447 DNA binding site [nucleotide binding] 1327988000448 domain linker motif; other site 1327988000449 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1327988000450 putative dimerization interface [polypeptide binding]; other site 1327988000451 putative ligand binding site [chemical binding]; other site 1327988000452 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1327988000453 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1327988000454 DNA binding site [nucleotide binding] 1327988000455 domain linker motif; other site 1327988000456 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1327988000457 ligand binding site [chemical binding]; other site 1327988000458 dimerization interface [polypeptide binding]; other site 1327988000459 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1327988000460 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1327988000461 Ca binding site [ion binding]; other site 1327988000462 active site 1327988000463 catalytic site [active] 1327988000464 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1327988000465 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1327988000466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988000467 dimer interface [polypeptide binding]; other site 1327988000468 conserved gate region; other site 1327988000469 putative PBP binding loops; other site 1327988000470 ABC-ATPase subunit interface; other site 1327988000471 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1327988000472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988000473 dimer interface [polypeptide binding]; other site 1327988000474 conserved gate region; other site 1327988000475 putative PBP binding loops; other site 1327988000476 ABC-ATPase subunit interface; other site 1327988000477 Predicted integral membrane protein [Function unknown]; Region: COG5521 1327988000478 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 1327988000479 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1327988000480 active site 1327988000481 catalytic site [active] 1327988000482 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1327988000483 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1327988000484 Walker A/P-loop; other site 1327988000485 ATP binding site [chemical binding]; other site 1327988000486 Q-loop/lid; other site 1327988000487 ABC transporter signature motif; other site 1327988000488 Walker B; other site 1327988000489 D-loop; other site 1327988000490 H-loop/switch region; other site 1327988000491 TOBE domain; Region: TOBE_2; pfam08402 1327988000492 maltose phosphorylase; Provisional; Region: PRK13807 1327988000493 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1327988000494 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1327988000495 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1327988000496 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 1327988000497 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 1327988000498 putative active site [active] 1327988000499 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1327988000500 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 1327988000501 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1327988000502 sugar binding site [chemical binding]; other site 1327988000503 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 1327988000504 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1327988000505 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1327988000506 nucleotide binding site [chemical binding]; other site 1327988000507 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1327988000508 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1327988000509 Melibiase; Region: Melibiase; pfam02065 1327988000510 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1327988000511 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1327988000512 active site turn [active] 1327988000513 phosphorylation site [posttranslational modification] 1327988000514 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1327988000515 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1327988000516 HPr interaction site; other site 1327988000517 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1327988000518 active site 1327988000519 phosphorylation site [posttranslational modification] 1327988000520 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1327988000521 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1327988000522 substrate binding [chemical binding]; other site 1327988000523 active site 1327988000524 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1327988000525 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1327988000526 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1327988000527 DNA binding site [nucleotide binding] 1327988000528 domain linker motif; other site 1327988000529 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1327988000530 dimerization interface [polypeptide binding]; other site 1327988000531 ligand binding site [chemical binding]; other site 1327988000532 sodium binding site [ion binding]; other site 1327988000533 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1327988000534 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1327988000535 Ca binding site [ion binding]; other site 1327988000536 active site 1327988000537 catalytic site [active] 1327988000538 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1327988000539 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1327988000540 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1327988000541 putative NAD(P) binding site [chemical binding]; other site 1327988000542 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1327988000543 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1327988000544 Ca binding site [ion binding]; other site 1327988000545 active site 1327988000546 catalytic site [active] 1327988000547 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988000548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1327988000549 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1327988000550 dimerization interface [polypeptide binding]; other site 1327988000551 Cna protein B-type domain; Region: Cna_B; pfam05738 1327988000552 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1327988000553 domain interaction interfaces [polypeptide binding]; other site 1327988000554 Cna protein B-type domain; Region: Cna_B; pfam05738 1327988000555 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1327988000556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988000557 non-specific DNA binding site [nucleotide binding]; other site 1327988000558 salt bridge; other site 1327988000559 sequence-specific DNA binding site [nucleotide binding]; other site 1327988000560 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1327988000561 peptide binding site [polypeptide binding]; other site 1327988000562 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1327988000563 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1327988000564 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1327988000565 peptide binding site [polypeptide binding]; other site 1327988000566 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1327988000567 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 1327988000568 putative ligand binding site [chemical binding]; other site 1327988000569 putative NAD binding site [chemical binding]; other site 1327988000570 putative catalytic site [active] 1327988000571 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1327988000572 L-serine binding site [chemical binding]; other site 1327988000573 ACT domain interface; other site 1327988000574 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1327988000575 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1327988000576 catalytic residue [active] 1327988000577 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1327988000578 catalytic core [active] 1327988000579 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1327988000580 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1327988000581 active site 1327988000582 catalytic tetrad [active] 1327988000583 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 1327988000584 Domain of unknown function (DU1801); Region: DUF1801; cl17490 1327988000585 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1327988000586 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1327988000587 propionate/acetate kinase; Provisional; Region: PRK12379 1327988000588 CrcB-like protein; Region: CRCB; cl09114 1327988000589 CrcB-like protein; Region: CRCB; cl09114 1327988000590 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1327988000591 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1327988000592 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1327988000593 ABC transporter; Region: ABC_tran_2; pfam12848 1327988000594 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1327988000595 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988000596 Helix-turn-helix domain; Region: HTH_38; pfam13936 1327988000597 Integrase core domain; Region: rve; pfam00665 1327988000598 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988000599 Walker B; other site 1327988000600 D-loop; other site 1327988000601 H-loop/switch region; other site 1327988000602 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1327988000603 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1327988000604 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1327988000605 Walker A/P-loop; other site 1327988000606 ATP binding site [chemical binding]; other site 1327988000607 Q-loop/lid; other site 1327988000608 ABC transporter signature motif; other site 1327988000609 Walker B; other site 1327988000610 D-loop; other site 1327988000611 H-loop/switch region; other site 1327988000612 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1327988000613 AAA domain; Region: AAA_23; pfam13476 1327988000614 Walker A/P-loop; other site 1327988000615 ATP binding site [chemical binding]; other site 1327988000616 ABC transporter; Region: ABC_tran; pfam00005 1327988000617 Q-loop/lid; other site 1327988000618 ABC transporter signature motif; other site 1327988000619 Walker B; other site 1327988000620 D-loop; other site 1327988000621 H-loop/switch region; other site 1327988000622 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1327988000623 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1327988000624 catalytic residues [active] 1327988000625 dimer interface [polypeptide binding]; other site 1327988000626 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1327988000627 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1327988000628 active site 1327988000629 catalytic tetrad [active] 1327988000630 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1327988000631 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1327988000632 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1327988000633 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1327988000634 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988000635 non-specific DNA binding site [nucleotide binding]; other site 1327988000636 salt bridge; other site 1327988000637 sequence-specific DNA binding site [nucleotide binding]; other site 1327988000638 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1327988000639 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1327988000640 active site 1327988000641 trimer interface [polypeptide binding]; other site 1327988000642 allosteric site; other site 1327988000643 active site lid [active] 1327988000644 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1327988000645 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988000646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988000647 putative substrate translocation pore; other site 1327988000648 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 1327988000649 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1327988000650 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1327988000651 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1327988000652 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1327988000653 Peptidase family C69; Region: Peptidase_C69; pfam03577 1327988000654 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1327988000655 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1327988000656 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1327988000657 active site 1327988000658 P-loop; other site 1327988000659 phosphorylation site [posttranslational modification] 1327988000660 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1327988000661 active site 1327988000662 P-loop; other site 1327988000663 phosphorylation site [posttranslational modification] 1327988000664 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1327988000665 PRD domain; Region: PRD; pfam00874 1327988000666 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1327988000667 active site 1327988000668 P-loop; other site 1327988000669 phosphorylation site [posttranslational modification] 1327988000670 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1327988000671 active site 1327988000672 phosphorylation site [posttranslational modification] 1327988000673 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1327988000674 active site 1327988000675 phosphorylation site [posttranslational modification] 1327988000676 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1327988000677 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1327988000678 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1327988000679 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1327988000680 DNA binding residues [nucleotide binding] 1327988000681 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1327988000682 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1327988000683 catalytic residues [active] 1327988000684 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1327988000685 active site 1327988000686 multimer interface [polypeptide binding]; other site 1327988000687 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1327988000688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1327988000689 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1327988000690 Predicted flavoprotein [General function prediction only]; Region: COG0431 1327988000691 serine O-acetyltransferase; Region: cysE; TIGR01172 1327988000692 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1327988000693 trimer interface [polypeptide binding]; other site 1327988000694 active site 1327988000695 substrate binding site [chemical binding]; other site 1327988000696 CoA binding site [chemical binding]; other site 1327988000697 cystathionine beta-lyase; Provisional; Region: PRK07671 1327988000698 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1327988000699 homodimer interface [polypeptide binding]; other site 1327988000700 substrate-cofactor binding pocket; other site 1327988000701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988000702 catalytic residue [active] 1327988000703 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1327988000704 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1327988000705 dimer interface [polypeptide binding]; other site 1327988000706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988000707 catalytic residue [active] 1327988000708 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1327988000709 methionine aminopeptidase; Provisional; Region: PRK08671 1327988000710 active site 1327988000711 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1327988000712 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 1327988000713 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1327988000714 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1327988000715 DNA-binding site [nucleotide binding]; DNA binding site 1327988000716 UTRA domain; Region: UTRA; pfam07702 1327988000717 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1327988000718 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1327988000719 Ca binding site [ion binding]; other site 1327988000720 active site 1327988000721 catalytic site [active] 1327988000722 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1327988000723 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1327988000724 HPr interaction site; other site 1327988000725 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1327988000726 active site 1327988000727 phosphorylation site [posttranslational modification] 1327988000728 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1327988000729 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1327988000730 active site turn [active] 1327988000731 phosphorylation site [posttranslational modification] 1327988000732 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1327988000733 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1327988000734 HPr interaction site; other site 1327988000735 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1327988000736 active site 1327988000737 phosphorylation site [posttranslational modification] 1327988000738 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1327988000739 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1327988000740 active site turn [active] 1327988000741 phosphorylation site [posttranslational modification] 1327988000742 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1327988000743 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1327988000744 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1327988000745 active site 1327988000746 nucleotide binding site [chemical binding]; other site 1327988000747 HIGH motif; other site 1327988000748 KMSKS motif; other site 1327988000749 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1327988000750 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1327988000751 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1327988000752 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1327988000753 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1327988000754 putative ADP-binding pocket [chemical binding]; other site 1327988000755 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1327988000756 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1327988000757 Flavoprotein; Region: Flavoprotein; pfam02441 1327988000758 Predicted transcriptional regulator [Transcription]; Region: COG1959 1327988000759 Transcriptional regulator; Region: Rrf2; pfam02082 1327988000760 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988000761 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988000762 manganese transport protein MntH; Reviewed; Region: PRK00701 1327988000763 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1327988000764 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1327988000765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988000766 putative substrate translocation pore; other site 1327988000767 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1327988000768 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1327988000769 DNA binding residues [nucleotide binding] 1327988000770 putative dimer interface [polypeptide binding]; other site 1327988000771 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1327988000772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1327988000773 dimer interface [polypeptide binding]; other site 1327988000774 phosphorylation site [posttranslational modification] 1327988000775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1327988000776 ATP binding site [chemical binding]; other site 1327988000777 Mg2+ binding site [ion binding]; other site 1327988000778 G-X-G motif; other site 1327988000779 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1327988000780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1327988000781 active site 1327988000782 phosphorylation site [posttranslational modification] 1327988000783 intermolecular recognition site; other site 1327988000784 dimerization interface [polypeptide binding]; other site 1327988000785 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1327988000786 DNA binding site [nucleotide binding] 1327988000787 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1327988000788 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1327988000789 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1327988000790 putative active site [active] 1327988000791 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1327988000792 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1327988000793 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1327988000794 FAD binding domain; Region: FAD_binding_4; pfam01565 1327988000795 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1327988000796 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1327988000797 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1327988000798 synthetase active site [active] 1327988000799 NTP binding site [chemical binding]; other site 1327988000800 metal binding site [ion binding]; metal-binding site 1327988000801 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1327988000802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988000803 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1327988000804 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1327988000805 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1327988000806 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1327988000807 Cation efflux family; Region: Cation_efflux; cl00316 1327988000808 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1327988000809 legume lectins; Region: lectin_L-type; cl14058 1327988000810 homotetramer interaction site [polypeptide binding]; other site 1327988000811 carbohydrate binding site [chemical binding]; other site 1327988000812 metal binding site [ion binding]; metal-binding site 1327988000813 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1327988000814 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1327988000815 FtsX-like permease family; Region: FtsX; pfam02687 1327988000816 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1327988000817 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1327988000818 Walker A/P-loop; other site 1327988000819 ATP binding site [chemical binding]; other site 1327988000820 Q-loop/lid; other site 1327988000821 ABC transporter signature motif; other site 1327988000822 Walker B; other site 1327988000823 D-loop; other site 1327988000824 H-loop/switch region; other site 1327988000825 CAAX protease self-immunity; Region: Abi; pfam02517 1327988000826 CAAX protease self-immunity; Region: Abi; pfam02517 1327988000827 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1327988000828 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1327988000829 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1327988000830 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1327988000831 lipoyl attachment site [posttranslational modification]; other site 1327988000832 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1327988000833 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1327988000834 DEAD_2; Region: DEAD_2; pfam06733 1327988000835 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1327988000836 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1327988000837 propionate/acetate kinase; Provisional; Region: PRK12379 1327988000838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1327988000839 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1327988000840 MarR family; Region: MarR_2; pfam12802 1327988000841 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 1327988000842 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1327988000843 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1327988000844 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1327988000845 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1327988000846 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1327988000847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988000848 dimer interface [polypeptide binding]; other site 1327988000849 conserved gate region; other site 1327988000850 putative PBP binding loops; other site 1327988000851 ABC-ATPase subunit interface; other site 1327988000852 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1327988000853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988000854 dimer interface [polypeptide binding]; other site 1327988000855 conserved gate region; other site 1327988000856 putative PBP binding loops; other site 1327988000857 ABC-ATPase subunit interface; other site 1327988000858 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1327988000859 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1327988000860 Walker A/P-loop; other site 1327988000861 ATP binding site [chemical binding]; other site 1327988000862 Q-loop/lid; other site 1327988000863 ABC transporter signature motif; other site 1327988000864 Walker B; other site 1327988000865 D-loop; other site 1327988000866 H-loop/switch region; other site 1327988000867 TOBE domain; Region: TOBE_2; pfam08402 1327988000868 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1327988000869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988000870 non-specific DNA binding site [nucleotide binding]; other site 1327988000871 salt bridge; other site 1327988000872 sequence-specific DNA binding site [nucleotide binding]; other site 1327988000873 Cupin domain; Region: Cupin_2; pfam07883 1327988000874 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1327988000875 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1327988000876 Coenzyme A binding pocket [chemical binding]; other site 1327988000877 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1327988000878 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1327988000879 Coenzyme A binding pocket [chemical binding]; other site 1327988000880 Predicted transcriptional regulators [Transcription]; Region: COG1725 1327988000881 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1327988000882 DNA-binding site [nucleotide binding]; DNA binding site 1327988000883 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1327988000884 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1327988000885 Walker A/P-loop; other site 1327988000886 ATP binding site [chemical binding]; other site 1327988000887 Q-loop/lid; other site 1327988000888 ABC transporter signature motif; other site 1327988000889 Walker B; other site 1327988000890 D-loop; other site 1327988000891 H-loop/switch region; other site 1327988000892 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1327988000893 putative catalytic cysteine [active] 1327988000894 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1327988000895 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1327988000896 intersubunit interface [polypeptide binding]; other site 1327988000897 active site 1327988000898 zinc binding site [ion binding]; other site 1327988000899 Na+ binding site [ion binding]; other site 1327988000900 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1327988000901 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1327988000902 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1327988000903 HflK protein; Region: hflK; TIGR01933 1327988000904 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988000905 Helix-turn-helix domain; Region: HTH_38; pfam13936 1327988000906 Integrase core domain; Region: rve; pfam00665 1327988000907 Peptidase family C69; Region: Peptidase_C69; pfam03577 1327988000908 BioY family; Region: BioY; pfam02632 1327988000909 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1327988000910 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1327988000911 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1327988000912 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1327988000913 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1327988000914 CHY zinc finger; Region: zf-CHY; pfam05495 1327988000915 transaminase; Reviewed; Region: PRK08068 1327988000916 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1327988000917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988000918 homodimer interface [polypeptide binding]; other site 1327988000919 catalytic residue [active] 1327988000920 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1327988000921 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1327988000922 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1327988000923 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1327988000924 Walker A/P-loop; other site 1327988000925 ATP binding site [chemical binding]; other site 1327988000926 Q-loop/lid; other site 1327988000927 ABC transporter signature motif; other site 1327988000928 Walker B; other site 1327988000929 D-loop; other site 1327988000930 H-loop/switch region; other site 1327988000931 type II secretion system protein F; Region: GspF; TIGR02120 1327988000932 Predicted transcriptional regulators [Transcription]; Region: COG1695 1327988000933 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1327988000934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988000935 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988000936 putative substrate translocation pore; other site 1327988000937 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1327988000938 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1327988000939 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1327988000940 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1327988000941 NAD binding site [chemical binding]; other site 1327988000942 dimer interface [polypeptide binding]; other site 1327988000943 substrate binding site [chemical binding]; other site 1327988000944 ATP-dependent protease Lon; Provisional; Region: PRK13765 1327988000945 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 1327988000946 active site 1327988000947 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1327988000948 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1327988000949 active site 1327988000950 dimer interface [polypeptide binding]; other site 1327988000951 multicopper oxidase; Provisional; Region: PRK10965 1327988000952 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1327988000953 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1327988000954 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1327988000955 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1327988000956 substrate binding site [chemical binding]; other site 1327988000957 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1327988000958 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1327988000959 Transcriptional regulator; Region: Rrf2; pfam02082 1327988000960 Rrf2 family protein; Region: rrf2_super; TIGR00738 1327988000961 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1327988000962 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1327988000963 carboxyltransferase (CT) interaction site; other site 1327988000964 biotinylation site [posttranslational modification]; other site 1327988000965 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1327988000966 active site 1327988000967 tetramer interface [polypeptide binding]; other site 1327988000968 short chain dehydrogenase; Validated; Region: PRK06182 1327988000969 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1327988000970 NADP binding site [chemical binding]; other site 1327988000971 active site 1327988000972 steroid binding site; other site 1327988000973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988000974 dimer interface [polypeptide binding]; other site 1327988000975 conserved gate region; other site 1327988000976 ABC-ATPase subunit interface; other site 1327988000977 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1327988000978 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1327988000979 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988000980 Walker A/P-loop; other site 1327988000981 ATP binding site [chemical binding]; other site 1327988000982 Q-loop/lid; other site 1327988000983 ABC transporter signature motif; other site 1327988000984 Walker B; other site 1327988000985 D-loop; other site 1327988000986 H-loop/switch region; other site 1327988000987 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1327988000988 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1327988000989 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1327988000990 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1327988000991 glycerol kinase; Provisional; Region: glpK; PRK00047 1327988000992 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1327988000993 N- and C-terminal domain interface [polypeptide binding]; other site 1327988000994 active site 1327988000995 MgATP binding site [chemical binding]; other site 1327988000996 catalytic site [active] 1327988000997 metal binding site [ion binding]; metal-binding site 1327988000998 glycerol binding site [chemical binding]; other site 1327988000999 homotetramer interface [polypeptide binding]; other site 1327988001000 homodimer interface [polypeptide binding]; other site 1327988001001 FBP binding site [chemical binding]; other site 1327988001002 protein IIAGlc interface [polypeptide binding]; other site 1327988001003 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1327988001004 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1327988001005 amphipathic channel; other site 1327988001006 Asn-Pro-Ala signature motifs; other site 1327988001007 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988001008 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 1327988001009 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 1327988001010 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1327988001011 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1327988001012 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1327988001013 MULE transposase domain; Region: MULE; pfam10551 1327988001014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1327988001015 ATP binding site [chemical binding]; other site 1327988001016 Mg2+ binding site [ion binding]; other site 1327988001017 G-X-G motif; other site 1327988001018 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1327988001019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1327988001020 active site 1327988001021 phosphorylation site [posttranslational modification] 1327988001022 intermolecular recognition site; other site 1327988001023 dimerization interface [polypeptide binding]; other site 1327988001024 LytTr DNA-binding domain; Region: LytTR; pfam04397 1327988001025 CAAX protease self-immunity; Region: Abi; pfam02517 1327988001026 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 1327988001027 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 1327988001028 putative active site [active] 1327988001029 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1327988001030 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988001031 Walker A/P-loop; other site 1327988001032 ATP binding site [chemical binding]; other site 1327988001033 Q-loop/lid; other site 1327988001034 ABC transporter signature motif; other site 1327988001035 Walker B; other site 1327988001036 D-loop; other site 1327988001037 H-loop/switch region; other site 1327988001038 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 1327988001039 HlyD family secretion protein; Region: HlyD_3; pfam13437 1327988001040 possible integrated plasmid 1327988001041 HTH-like domain; Region: HTH_21; pfam13276 1327988001042 Integrase core domain; Region: rve; pfam00665 1327988001043 Integrase core domain; Region: rve_3; pfam13683 1327988001044 Helix-turn-helix domain; Region: HTH_28; pfam13518 1327988001045 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 1327988001046 active site 1327988001047 NTP binding site [chemical binding]; other site 1327988001048 metal binding triad [ion binding]; metal-binding site 1327988001049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1327988001050 Transposase; Region: HTH_Tnp_1; pfam01527 1327988001051 putative transposase OrfB; Reviewed; Region: PHA02517 1327988001052 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1327988001053 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1327988001054 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1327988001055 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1327988001056 catalytic residues [active] 1327988001057 catalytic nucleophile [active] 1327988001058 Presynaptic Site I dimer interface [polypeptide binding]; other site 1327988001059 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1327988001060 Synaptic Flat tetramer interface [polypeptide binding]; other site 1327988001061 Synaptic Site I dimer interface [polypeptide binding]; other site 1327988001062 DNA binding site [nucleotide binding] 1327988001063 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1327988001064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988001065 putative substrate translocation pore; other site 1327988001066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988001067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988001068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988001069 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1327988001070 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1327988001071 P-loop; other site 1327988001072 Magnesium ion binding site [ion binding]; other site 1327988001073 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1327988001074 Magnesium ion binding site [ion binding]; other site 1327988001075 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1327988001076 RelB antitoxin; Region: RelB; cl01171 1327988001077 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 1327988001078 MobA/MobL family; Region: MobA_MobL; pfam03389 1327988001079 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 1327988001080 phosphate binding site [ion binding]; other site 1327988001081 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 1327988001082 domain III; other site 1327988001083 nucleotide binding site [chemical binding]; other site 1327988001084 DNA binding groove [nucleotide binding] 1327988001085 catalytic site [active] 1327988001086 domain II; other site 1327988001087 domain IV; other site 1327988001088 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1327988001089 Cation efflux family; Region: Cation_efflux; pfam01545 1327988001090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988001091 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1327988001092 putative substrate translocation pore; other site 1327988001093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988001094 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1327988001095 MarR family; Region: MarR_2; pfam12802 1327988001096 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1327988001097 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1327988001098 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1327988001099 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1327988001100 Integrase core domain; Region: rve; pfam00665 1327988001101 Integrase core domain; Region: rve_3; pfam13683 1327988001102 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1327988001103 catalytic residues [active] 1327988001104 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1327988001105 catalytic nucleophile [active] 1327988001106 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 1327988001107 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 1327988001108 putative active site [active] 1327988001109 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1327988001110 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988001111 Walker A/P-loop; other site 1327988001112 ATP binding site [chemical binding]; other site 1327988001113 Q-loop/lid; other site 1327988001114 ABC transporter signature motif; other site 1327988001115 Walker B; other site 1327988001116 D-loop; other site 1327988001117 H-loop/switch region; other site 1327988001118 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 1327988001119 HlyD family secretion protein; Region: HlyD_3; pfam13437 1327988001120 CAAX protease self-immunity; Region: Abi; pfam02517 1327988001121 CAAX protease self-immunity; Region: Abi; pfam02517 1327988001122 CAAX protease self-immunity; Region: Abi; pfam02517 1327988001123 CAAX protease self-immunity; Region: Abi; pfam02517 1327988001124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1327988001125 sequence-specific DNA binding site [nucleotide binding]; other site 1327988001126 salt bridge; other site 1327988001127 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1327988001128 Part of AAA domain; Region: AAA_19; pfam13245 1327988001129 Family description; Region: UvrD_C_2; pfam13538 1327988001130 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1327988001131 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1327988001132 putative active site [active] 1327988001133 catalytic triad [active] 1327988001134 putative dimer interface [polypeptide binding]; other site 1327988001135 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1327988001136 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1327988001137 active site 1327988001138 HIGH motif; other site 1327988001139 dimer interface [polypeptide binding]; other site 1327988001140 KMSKS motif; other site 1327988001141 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1327988001142 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1327988001143 DNA-binding site [nucleotide binding]; DNA binding site 1327988001144 UTRA domain; Region: UTRA; pfam07702 1327988001145 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1327988001146 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1327988001147 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 1327988001148 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1327988001149 PemK-like protein; Region: PemK; pfam02452 1327988001150 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1327988001151 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1327988001152 FMN binding site [chemical binding]; other site 1327988001153 active site 1327988001154 catalytic residues [active] 1327988001155 substrate binding site [chemical binding]; other site 1327988001156 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1327988001157 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1327988001158 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1327988001159 homodimer interface [polypeptide binding]; other site 1327988001160 catalytic residues [active] 1327988001161 NAD binding site [chemical binding]; other site 1327988001162 substrate binding pocket [chemical binding]; other site 1327988001163 flexible flap; other site 1327988001164 NAD-dependent deacetylase; Provisional; Region: PRK00481 1327988001165 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 1327988001166 NAD+ binding site [chemical binding]; other site 1327988001167 substrate binding site [chemical binding]; other site 1327988001168 putative Zn binding site [ion binding]; other site 1327988001169 Protein of unknown function DUF72; Region: DUF72; pfam01904 1327988001170 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1327988001171 nudix motif; other site 1327988001172 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1327988001173 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1327988001174 HIGH motif; other site 1327988001175 active site 1327988001176 KMSKS motif; other site 1327988001177 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1327988001178 tRNA binding surface [nucleotide binding]; other site 1327988001179 anticodon binding site; other site 1327988001180 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1327988001181 dimer interface [polypeptide binding]; other site 1327988001182 putative tRNA-binding site [nucleotide binding]; other site 1327988001183 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1327988001184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988001185 putative substrate translocation pore; other site 1327988001186 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1327988001187 active site 1327988001188 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1327988001189 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1327988001190 putative active site [active] 1327988001191 putative metal binding site [ion binding]; other site 1327988001192 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1327988001193 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1327988001194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1327988001195 S-adenosylmethionine binding site [chemical binding]; other site 1327988001196 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1327988001197 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1327988001198 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1327988001199 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1327988001200 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1327988001201 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1327988001202 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1327988001203 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1327988001204 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1327988001205 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1327988001206 putative PBP binding regions; other site 1327988001207 ABC-ATPase subunit interface; other site 1327988001208 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1327988001209 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1327988001210 pur operon repressor; Provisional; Region: PRK09213 1327988001211 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1327988001212 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1327988001213 active site 1327988001214 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1327988001215 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1327988001216 Substrate binding site; other site 1327988001217 Mg++ binding site; other site 1327988001218 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1327988001219 active site 1327988001220 substrate binding site [chemical binding]; other site 1327988001221 CoA binding site [chemical binding]; other site 1327988001222 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1327988001223 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1327988001224 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1327988001225 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1327988001226 active site 1327988001227 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1327988001228 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1327988001229 putative active site [active] 1327988001230 putative transposase OrfB; Reviewed; Region: PHA02517 1327988001231 HTH-like domain; Region: HTH_21; pfam13276 1327988001232 Integrase core domain; Region: rve; pfam00665 1327988001233 Integrase core domain; Region: rve_2; pfam13333 1327988001234 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1327988001235 Helix-turn-helix domain; Region: HTH_28; pfam13518 1327988001236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1327988001237 Helix-turn-helix domain; Region: HTH_28; pfam13518 1327988001238 sugar phosphate phosphatase; Provisional; Region: PRK10513 1327988001239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988001240 active site 1327988001241 motif I; other site 1327988001242 motif II; other site 1327988001243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988001244 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1327988001245 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1327988001246 Zn2+ binding site [ion binding]; other site 1327988001247 Mg2+ binding site [ion binding]; other site 1327988001248 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1327988001249 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1327988001250 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1327988001251 CTP synthetase; Validated; Region: pyrG; PRK05380 1327988001252 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1327988001253 Catalytic site [active] 1327988001254 active site 1327988001255 UTP binding site [chemical binding]; other site 1327988001256 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1327988001257 active site 1327988001258 putative oxyanion hole; other site 1327988001259 catalytic triad [active] 1327988001260 seryl-tRNA synthetase; Provisional; Region: PRK05431 1327988001261 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1327988001262 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1327988001263 dimer interface [polypeptide binding]; other site 1327988001264 active site 1327988001265 motif 1; other site 1327988001266 motif 2; other site 1327988001267 motif 3; other site 1327988001268 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1327988001269 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1327988001270 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1327988001271 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1327988001272 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1327988001273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1327988001274 YheO-like PAS domain; Region: PAS_6; pfam08348 1327988001275 HTH domain; Region: HTH_22; pfam13309 1327988001276 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1327988001277 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1327988001278 hinge; other site 1327988001279 active site 1327988001280 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1327988001281 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1327988001282 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1327988001283 RNA binding site [nucleotide binding]; other site 1327988001284 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1327988001285 multimer interface [polypeptide binding]; other site 1327988001286 Walker A motif; other site 1327988001287 ATP binding site [chemical binding]; other site 1327988001288 Walker B motif; other site 1327988001289 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1327988001290 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1327988001291 active site 1327988001292 catalytic site [active] 1327988001293 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1327988001294 heat shock protein HtpX; Provisional; Region: PRK04897 1327988001295 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1327988001296 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1327988001297 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1327988001298 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1327988001299 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1327988001300 ATP binding site [chemical binding]; other site 1327988001301 Mg++ binding site [ion binding]; other site 1327988001302 motif III; other site 1327988001303 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1327988001304 nucleotide binding region [chemical binding]; other site 1327988001305 ATP-binding site [chemical binding]; other site 1327988001306 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1327988001307 alanine racemase; Reviewed; Region: alr; PRK00053 1327988001308 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1327988001309 active site 1327988001310 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1327988001311 dimer interface [polypeptide binding]; other site 1327988001312 substrate binding site [chemical binding]; other site 1327988001313 catalytic residues [active] 1327988001314 PemK-like protein; Region: PemK; pfam02452 1327988001315 K+ potassium transporter; Region: K_trans; cl15781 1327988001316 NMT1/THI5 like; Region: NMT1; pfam09084 1327988001317 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1327988001318 substrate binding pocket [chemical binding]; other site 1327988001319 membrane-bound complex binding site; other site 1327988001320 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1327988001321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988001322 dimer interface [polypeptide binding]; other site 1327988001323 conserved gate region; other site 1327988001324 putative PBP binding loops; other site 1327988001325 ABC-ATPase subunit interface; other site 1327988001326 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1327988001327 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1327988001328 Walker A/P-loop; other site 1327988001329 ATP binding site [chemical binding]; other site 1327988001330 Q-loop/lid; other site 1327988001331 ABC transporter signature motif; other site 1327988001332 Walker B; other site 1327988001333 D-loop; other site 1327988001334 H-loop/switch region; other site 1327988001335 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1327988001336 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1327988001337 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1327988001338 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1327988001339 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1327988001340 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1327988001341 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1327988001342 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1327988001343 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1327988001344 catalytic site [active] 1327988001345 subunit interface [polypeptide binding]; other site 1327988001346 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1327988001347 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1327988001348 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1327988001349 heterotetramer interface [polypeptide binding]; other site 1327988001350 active site pocket [active] 1327988001351 cleavage site 1327988001352 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1327988001353 nucleotide binding site [chemical binding]; other site 1327988001354 N-acetyl-L-glutamate binding site [chemical binding]; other site 1327988001355 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1327988001356 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1327988001357 inhibitor-cofactor binding pocket; inhibition site 1327988001358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988001359 catalytic residue [active] 1327988001360 ornithine carbamoyltransferase; Validated; Region: PRK02102 1327988001361 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1327988001362 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1327988001363 QueT transporter; Region: QueT; pfam06177 1327988001364 FOG: CBS domain [General function prediction only]; Region: COG0517 1327988001365 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1327988001366 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1327988001367 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1327988001368 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1327988001369 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1327988001370 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1327988001371 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1327988001372 NAD binding site [chemical binding]; other site 1327988001373 dimer interface [polypeptide binding]; other site 1327988001374 substrate binding site [chemical binding]; other site 1327988001375 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1327988001376 putative active site [active] 1327988001377 catalytic residue [active] 1327988001378 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1327988001379 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1327988001380 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1327988001381 ATP binding site [chemical binding]; other site 1327988001382 putative Mg++ binding site [ion binding]; other site 1327988001383 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1327988001384 nucleotide binding region [chemical binding]; other site 1327988001385 ATP-binding site [chemical binding]; other site 1327988001386 TRCF domain; Region: TRCF; pfam03461 1327988001387 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1327988001388 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1327988001389 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1327988001390 RNA binding surface [nucleotide binding]; other site 1327988001391 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1327988001392 Septum formation initiator; Region: DivIC; pfam04977 1327988001393 hypothetical protein; Provisional; Region: PRK08582 1327988001394 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1327988001395 RNA binding site [nucleotide binding]; other site 1327988001396 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1327988001397 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1327988001398 Ligand Binding Site [chemical binding]; other site 1327988001399 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1327988001400 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1327988001401 active site 1327988001402 FtsH Extracellular; Region: FtsH_ext; pfam06480 1327988001403 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1327988001404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988001405 Walker A motif; other site 1327988001406 ATP binding site [chemical binding]; other site 1327988001407 Walker B motif; other site 1327988001408 arginine finger; other site 1327988001409 Peptidase family M41; Region: Peptidase_M41; pfam01434 1327988001410 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1327988001411 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1327988001412 dimerization interface [polypeptide binding]; other site 1327988001413 domain crossover interface; other site 1327988001414 redox-dependent activation switch; other site 1327988001415 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1327988001416 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1327988001417 FMN binding site [chemical binding]; other site 1327988001418 active site 1327988001419 catalytic residues [active] 1327988001420 substrate binding site [chemical binding]; other site 1327988001421 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1327988001422 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1327988001423 dimer interface [polypeptide binding]; other site 1327988001424 putative anticodon binding site; other site 1327988001425 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1327988001426 motif 1; other site 1327988001427 active site 1327988001428 motif 2; other site 1327988001429 motif 3; other site 1327988001430 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1327988001431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988001432 putative substrate translocation pore; other site 1327988001433 POT family; Region: PTR2; cl17359 1327988001434 putative phosphoesterase; Region: acc_ester; TIGR03729 1327988001435 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1327988001436 Cupin domain; Region: Cupin_2; cl17218 1327988001437 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1327988001438 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1327988001439 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1327988001440 active site 1327988001441 metal binding site [ion binding]; metal-binding site 1327988001442 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1327988001443 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1327988001444 transmembrane helices; other site 1327988001445 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1327988001446 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1327988001447 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1327988001448 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1327988001449 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1327988001450 active site 1327988001451 dimer interface [polypeptide binding]; other site 1327988001452 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1327988001453 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1327988001454 DNA-binding site [nucleotide binding]; DNA binding site 1327988001455 UTRA domain; Region: UTRA; pfam07702 1327988001456 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1327988001457 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1327988001458 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1327988001459 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1327988001460 active site 1327988001461 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1327988001462 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1327988001463 homodimer interface [polypeptide binding]; other site 1327988001464 NAD binding pocket [chemical binding]; other site 1327988001465 ATP binding pocket [chemical binding]; other site 1327988001466 Mg binding site [ion binding]; other site 1327988001467 active-site loop [active] 1327988001468 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1327988001469 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1327988001470 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1327988001471 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1327988001472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988001473 motif II; other site 1327988001474 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1327988001475 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1327988001476 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1327988001477 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1327988001478 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1327988001479 RNA binding site [nucleotide binding]; other site 1327988001480 hypothetical protein; Provisional; Region: PRK04351 1327988001481 SprT homologues; Region: SprT; cl01182 1327988001482 homoserine dehydrogenase; Provisional; Region: PRK06349 1327988001483 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1327988001484 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1327988001485 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1327988001486 homoserine kinase; Provisional; Region: PRK01212 1327988001487 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1327988001488 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1327988001489 putative active site [active] 1327988001490 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1327988001491 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1327988001492 active pocket/dimerization site; other site 1327988001493 active site 1327988001494 phosphorylation site [posttranslational modification] 1327988001495 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1327988001496 active site 1327988001497 phosphorylation site [posttranslational modification] 1327988001498 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1327988001499 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1327988001500 Domain of unknown function (DUF956); Region: DUF956; pfam06115 1327988001501 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1327988001502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988001503 Walker A motif; other site 1327988001504 ATP binding site [chemical binding]; other site 1327988001505 Walker B motif; other site 1327988001506 arginine finger; other site 1327988001507 Transcriptional antiterminator [Transcription]; Region: COG3933 1327988001508 PRD domain; Region: PRD; pfam00874 1327988001509 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1327988001510 active pocket/dimerization site; other site 1327988001511 active site 1327988001512 phosphorylation site [posttranslational modification] 1327988001513 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1327988001514 active pocket/dimerization site; other site 1327988001515 active site 1327988001516 phosphorylation site [posttranslational modification] 1327988001517 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1327988001518 active site 1327988001519 phosphorylation site [posttranslational modification] 1327988001520 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1327988001521 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1327988001522 dimer interface [polypeptide binding]; other site 1327988001523 active site 1327988001524 CoA binding pocket [chemical binding]; other site 1327988001525 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1327988001526 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1327988001527 carboxyltransferase (CT) interaction site; other site 1327988001528 biotinylation site [posttranslational modification]; other site 1327988001529 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1327988001530 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1327988001531 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1327988001532 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1327988001533 acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515 1327988001534 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1327988001535 substrate binding site [chemical binding]; other site 1327988001536 trimer interface [polypeptide binding]; other site 1327988001537 oxyanion hole (OAH) forming residues; other site 1327988001538 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1327988001539 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1327988001540 Membrane transport protein; Region: Mem_trans; pfam03547 1327988001541 EamA-like transporter family; Region: EamA; pfam00892 1327988001542 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1327988001543 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1327988001544 catalytic core [active] 1327988001545 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1327988001546 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 1327988001547 active site 1327988001548 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1327988001549 trimer interface [polypeptide binding]; other site 1327988001550 active site 1327988001551 G bulge; other site 1327988001552 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1327988001553 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1327988001554 active site 1327988001555 dimer interface [polypeptide binding]; other site 1327988001556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1327988001557 Coenzyme A binding pocket [chemical binding]; other site 1327988001558 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1327988001559 trimer interface [polypeptide binding]; other site 1327988001560 active site 1327988001561 DNA repair protein RadA; Provisional; Region: PRK11823 1327988001562 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1327988001563 Walker A motif/ATP binding site; other site 1327988001564 ATP binding site [chemical binding]; other site 1327988001565 Walker B motif; other site 1327988001566 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1327988001567 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1327988001568 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1327988001569 putative active site [active] 1327988001570 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1327988001571 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1327988001572 active site 1327988001573 HIGH motif; other site 1327988001574 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1327988001575 active site 1327988001576 KMSKS motif; other site 1327988001577 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1327988001578 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1327988001579 active site 1327988001580 HIGH motif; other site 1327988001581 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1327988001582 KMSKS motif; other site 1327988001583 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1327988001584 tRNA binding surface [nucleotide binding]; other site 1327988001585 anticodon binding site; other site 1327988001586 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1327988001587 active site 1327988001588 metal binding site [ion binding]; metal-binding site 1327988001589 dimerization interface [polypeptide binding]; other site 1327988001590 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1327988001591 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1327988001592 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1327988001593 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1327988001594 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1327988001595 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1327988001596 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1327988001597 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1327988001598 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1327988001599 putative homodimer interface [polypeptide binding]; other site 1327988001600 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1327988001601 heterodimer interface [polypeptide binding]; other site 1327988001602 homodimer interface [polypeptide binding]; other site 1327988001603 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1327988001604 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1327988001605 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1327988001606 23S rRNA interface [nucleotide binding]; other site 1327988001607 L7/L12 interface [polypeptide binding]; other site 1327988001608 putative thiostrepton binding site; other site 1327988001609 L25 interface [polypeptide binding]; other site 1327988001610 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1327988001611 mRNA/rRNA interface [nucleotide binding]; other site 1327988001612 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1327988001613 23S rRNA interface [nucleotide binding]; other site 1327988001614 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1327988001615 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1327988001616 peripheral dimer interface [polypeptide binding]; other site 1327988001617 core dimer interface [polypeptide binding]; other site 1327988001618 L10 interface [polypeptide binding]; other site 1327988001619 L11 interface [polypeptide binding]; other site 1327988001620 putative EF-Tu interaction site [polypeptide binding]; other site 1327988001621 putative EF-G interaction site [polypeptide binding]; other site 1327988001622 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 1327988001623 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1327988001624 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1327988001625 Predicted integral membrane protein [Function unknown]; Region: COG0392 1327988001626 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1327988001627 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1327988001628 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1327988001629 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1327988001630 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1327988001631 dimer interface [polypeptide binding]; other site 1327988001632 putative radical transfer pathway; other site 1327988001633 diiron center [ion binding]; other site 1327988001634 tyrosyl radical; other site 1327988001635 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 1327988001636 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1327988001637 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1327988001638 active site 1327988001639 dimer interface [polypeptide binding]; other site 1327988001640 catalytic residues [active] 1327988001641 effector binding site; other site 1327988001642 R2 peptide binding site; other site 1327988001643 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1327988001644 catalytic residues [active] 1327988001645 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1327988001646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1327988001647 S-adenosylmethionine binding site [chemical binding]; other site 1327988001648 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1327988001649 nucleoside/Zn binding site; other site 1327988001650 dimer interface [polypeptide binding]; other site 1327988001651 catalytic motif [active] 1327988001652 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1327988001653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988001654 Walker A motif; other site 1327988001655 ATP binding site [chemical binding]; other site 1327988001656 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1327988001657 Walker B motif; other site 1327988001658 arginine finger; other site 1327988001659 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1327988001660 hypothetical protein; Validated; Region: PRK00153 1327988001661 recombination protein RecR; Reviewed; Region: recR; PRK00076 1327988001662 RecR protein; Region: RecR; pfam02132 1327988001663 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1327988001664 putative active site [active] 1327988001665 putative metal-binding site [ion binding]; other site 1327988001666 tetramer interface [polypeptide binding]; other site 1327988001667 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1327988001668 thymidylate kinase; Validated; Region: tmk; PRK00698 1327988001669 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1327988001670 TMP-binding site; other site 1327988001671 ATP-binding site [chemical binding]; other site 1327988001672 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1327988001673 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1327988001674 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1327988001675 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1327988001676 Predicted methyltransferases [General function prediction only]; Region: COG0313 1327988001677 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1327988001678 putative SAM binding site [chemical binding]; other site 1327988001679 putative homodimer interface [polypeptide binding]; other site 1327988001680 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 1327988001681 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1327988001682 active site 1327988001683 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1327988001684 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1327988001685 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1327988001686 NAD binding site [chemical binding]; other site 1327988001687 homodimer interface [polypeptide binding]; other site 1327988001688 active site 1327988001689 substrate binding site [chemical binding]; other site 1327988001690 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 1327988001691 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1327988001692 catalytic residue [active] 1327988001693 phosphonoacetaldehyde hydrolase; Region: phosphonatase; TIGR01422 1327988001694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988001695 motif II; other site 1327988001696 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1327988001697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988001698 dimer interface [polypeptide binding]; other site 1327988001699 conserved gate region; other site 1327988001700 ABC-ATPase subunit interface; other site 1327988001701 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1327988001702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988001703 dimer interface [polypeptide binding]; other site 1327988001704 conserved gate region; other site 1327988001705 ABC-ATPase subunit interface; other site 1327988001706 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 1327988001707 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1327988001708 Walker A/P-loop; other site 1327988001709 ATP binding site [chemical binding]; other site 1327988001710 Q-loop/lid; other site 1327988001711 ABC transporter signature motif; other site 1327988001712 Walker B; other site 1327988001713 D-loop; other site 1327988001714 H-loop/switch region; other site 1327988001715 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1327988001716 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1327988001717 Glycoprotease family; Region: Peptidase_M22; pfam00814 1327988001718 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1327988001719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1327988001720 Coenzyme A binding pocket [chemical binding]; other site 1327988001721 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1327988001722 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1327988001723 Coenzyme A binding pocket [chemical binding]; other site 1327988001724 UGMP family protein; Validated; Region: PRK09604 1327988001725 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1327988001726 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1327988001727 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1327988001728 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1327988001729 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1327988001730 ABC transporter; Region: ABC_tran_2; pfam12848 1327988001731 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1327988001732 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1327988001733 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1327988001734 CoA binding domain; Region: CoA_binding; pfam02629 1327988001735 CAAX protease self-immunity; Region: Abi; pfam02517 1327988001736 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1327988001737 oligomerisation interface [polypeptide binding]; other site 1327988001738 mobile loop; other site 1327988001739 roof hairpin; other site 1327988001740 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1327988001741 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1327988001742 ring oligomerisation interface [polypeptide binding]; other site 1327988001743 ATP/Mg binding site [chemical binding]; other site 1327988001744 stacking interactions; other site 1327988001745 hinge regions; other site 1327988001746 Amino acid permease; Region: AA_permease_2; pfam13520 1327988001747 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1327988001748 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1327988001749 Mg++ binding site [ion binding]; other site 1327988001750 putative catalytic motif [active] 1327988001751 substrate binding site [chemical binding]; other site 1327988001752 PBP superfamily domain; Region: PBP_like_2; cl17296 1327988001753 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1327988001754 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1327988001755 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1327988001756 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1327988001757 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1327988001758 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1327988001759 ATP binding site [chemical binding]; other site 1327988001760 putative Mg++ binding site [ion binding]; other site 1327988001761 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1327988001762 ATP-binding site [chemical binding]; other site 1327988001763 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1327988001764 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1327988001765 active site 1327988001766 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1327988001767 30S subunit binding site; other site 1327988001768 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 1327988001769 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1327988001770 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1327988001771 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1327988001772 nucleotide binding region [chemical binding]; other site 1327988001773 ATP-binding site [chemical binding]; other site 1327988001774 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1327988001775 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1327988001776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1327988001777 active site 1327988001778 phosphorylation site [posttranslational modification] 1327988001779 intermolecular recognition site; other site 1327988001780 dimerization interface [polypeptide binding]; other site 1327988001781 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1327988001782 DNA binding site [nucleotide binding] 1327988001783 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1327988001784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1327988001785 dimer interface [polypeptide binding]; other site 1327988001786 phosphorylation site [posttranslational modification] 1327988001787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1327988001788 ATP binding site [chemical binding]; other site 1327988001789 Mg2+ binding site [ion binding]; other site 1327988001790 G-X-G motif; other site 1327988001791 PBP superfamily domain; Region: PBP_like_2; cl17296 1327988001792 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1327988001793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988001794 dimer interface [polypeptide binding]; other site 1327988001795 conserved gate region; other site 1327988001796 putative PBP binding loops; other site 1327988001797 ABC-ATPase subunit interface; other site 1327988001798 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1327988001799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988001800 putative PBP binding loops; other site 1327988001801 ABC-ATPase subunit interface; other site 1327988001802 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 1327988001803 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1327988001804 Walker A/P-loop; other site 1327988001805 ATP binding site [chemical binding]; other site 1327988001806 Q-loop/lid; other site 1327988001807 ABC transporter signature motif; other site 1327988001808 Walker B; other site 1327988001809 D-loop; other site 1327988001810 H-loop/switch region; other site 1327988001811 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 1327988001812 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1327988001813 Walker A/P-loop; other site 1327988001814 ATP binding site [chemical binding]; other site 1327988001815 Q-loop/lid; other site 1327988001816 ABC transporter signature motif; other site 1327988001817 Walker B; other site 1327988001818 D-loop; other site 1327988001819 H-loop/switch region; other site 1327988001820 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1327988001821 PhoU domain; Region: PhoU; pfam01895 1327988001822 PhoU domain; Region: PhoU; pfam01895 1327988001823 PspC domain; Region: PspC; pfam04024 1327988001824 Predicted membrane protein [Function unknown]; Region: COG1950 1327988001825 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1327988001826 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1327988001827 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1327988001828 Hpr binding site; other site 1327988001829 active site 1327988001830 homohexamer subunit interaction site [polypeptide binding]; other site 1327988001831 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1327988001832 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1327988001833 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1327988001834 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1327988001835 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1327988001836 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1327988001837 active site 1327988001838 tetramer interface; other site 1327988001839 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1327988001840 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1327988001841 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1327988001842 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1327988001843 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1327988001844 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1327988001845 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1327988001846 Predicted membrane protein [Function unknown]; Region: COG2323 1327988001847 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 1327988001848 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1327988001849 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1327988001850 active site 1327988001851 substrate binding site [chemical binding]; other site 1327988001852 metal binding site [ion binding]; metal-binding site 1327988001853 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1327988001854 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1327988001855 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1327988001856 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1327988001857 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1327988001858 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1327988001859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988001860 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988001861 putative substrate translocation pore; other site 1327988001862 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1327988001863 Zn2+ binding site [ion binding]; other site 1327988001864 Mg2+ binding site [ion binding]; other site 1327988001865 excinuclease ABC subunit B; Provisional; Region: PRK05298 1327988001866 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1327988001867 ATP binding site [chemical binding]; other site 1327988001868 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1327988001869 nucleotide binding region [chemical binding]; other site 1327988001870 ATP-binding site [chemical binding]; other site 1327988001871 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1327988001872 UvrB/uvrC motif; Region: UVR; pfam02151 1327988001873 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1327988001874 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1327988001875 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1327988001876 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1327988001877 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1327988001878 argininosuccinate synthase; Provisional; Region: PRK13820 1327988001879 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1327988001880 ANP binding site [chemical binding]; other site 1327988001881 Substrate Binding Site II [chemical binding]; other site 1327988001882 Substrate Binding Site I [chemical binding]; other site 1327988001883 argininosuccinate lyase; Provisional; Region: PRK00855 1327988001884 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1327988001885 active sites [active] 1327988001886 tetramer interface [polypeptide binding]; other site 1327988001887 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1327988001888 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1327988001889 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1327988001890 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1327988001891 phosphate binding site [ion binding]; other site 1327988001892 putative substrate binding pocket [chemical binding]; other site 1327988001893 dimer interface [polypeptide binding]; other site 1327988001894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1327988001895 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1327988001896 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1327988001897 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1327988001898 peptide binding site [polypeptide binding]; other site 1327988001899 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1327988001900 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1327988001901 putative ligand binding site [chemical binding]; other site 1327988001902 putative NAD binding site [chemical binding]; other site 1327988001903 catalytic site [active] 1327988001904 Clp protease; Region: CLP_protease; pfam00574 1327988001905 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1327988001906 oligomer interface [polypeptide binding]; other site 1327988001907 active site residues [active] 1327988001908 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1327988001909 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1327988001910 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1327988001911 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1327988001912 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1327988001913 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1327988001914 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1327988001915 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1327988001916 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1327988001917 Phosphoglycerate kinase; Region: PGK; pfam00162 1327988001918 substrate binding site [chemical binding]; other site 1327988001919 hinge regions; other site 1327988001920 ADP binding site [chemical binding]; other site 1327988001921 catalytic site [active] 1327988001922 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1327988001923 triosephosphate isomerase; Provisional; Region: PRK14567 1327988001924 substrate binding site [chemical binding]; other site 1327988001925 dimer interface [polypeptide binding]; other site 1327988001926 catalytic triad [active] 1327988001927 enolase; Provisional; Region: eno; PRK00077 1327988001928 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1327988001929 dimer interface [polypeptide binding]; other site 1327988001930 metal binding site [ion binding]; metal-binding site 1327988001931 substrate binding pocket [chemical binding]; other site 1327988001932 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1327988001933 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1327988001934 Cl- selectivity filter; other site 1327988001935 Cl- binding residues [ion binding]; other site 1327988001936 pore gating glutamate residue; other site 1327988001937 dimer interface [polypeptide binding]; other site 1327988001938 H+/Cl- coupling transport residue; other site 1327988001939 TrkA-C domain; Region: TrkA_C; pfam02080 1327988001940 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1327988001941 Esterase/lipase [General function prediction only]; Region: COG1647 1327988001942 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1327988001943 ribonuclease R; Region: RNase_R; TIGR02063 1327988001944 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1327988001945 RNB domain; Region: RNB; pfam00773 1327988001946 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1327988001947 RNA binding site [nucleotide binding]; other site 1327988001948 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1327988001949 SmpB-tmRNA interface; other site 1327988001950 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1327988001951 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1327988001952 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1327988001953 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1327988001954 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 1327988001955 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1327988001956 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1327988001957 substrate binding pocket [chemical binding]; other site 1327988001958 membrane-bound complex binding site; other site 1327988001959 hinge residues; other site 1327988001960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988001961 dimer interface [polypeptide binding]; other site 1327988001962 conserved gate region; other site 1327988001963 putative PBP binding loops; other site 1327988001964 ABC-ATPase subunit interface; other site 1327988001965 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1327988001966 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1327988001967 Walker A/P-loop; other site 1327988001968 ATP binding site [chemical binding]; other site 1327988001969 Q-loop/lid; other site 1327988001970 ABC transporter signature motif; other site 1327988001971 Walker B; other site 1327988001972 D-loop; other site 1327988001973 H-loop/switch region; other site 1327988001974 Tubby C 2; Region: Tub_2; cl02043 1327988001975 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988001976 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1327988001977 active site 1327988001978 motif I; other site 1327988001979 motif II; other site 1327988001980 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1327988001981 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1327988001982 ligand binding site [chemical binding]; other site 1327988001983 active site 1327988001984 UGI interface [polypeptide binding]; other site 1327988001985 catalytic site [active] 1327988001986 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1327988001987 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1327988001988 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1327988001989 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1327988001990 Coenzyme A binding pocket [chemical binding]; other site 1327988001991 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1327988001992 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1327988001993 active site 1327988001994 catalytic site [active] 1327988001995 substrate binding site [chemical binding]; other site 1327988001996 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1327988001997 active site 1327988001998 putative catalytic site [active] 1327988001999 DNA binding site [nucleotide binding] 1327988002000 putative phosphate binding site [ion binding]; other site 1327988002001 metal binding site A [ion binding]; metal-binding site 1327988002002 AP binding site [nucleotide binding]; other site 1327988002003 metal binding site B [ion binding]; metal-binding site 1327988002004 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1327988002005 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1327988002006 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1327988002007 FAD binding domain; Region: FAD_binding_4; pfam01565 1327988002008 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1327988002009 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1327988002010 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1327988002011 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1327988002012 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 1327988002013 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1327988002014 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1327988002015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1327988002016 YbbR-like protein; Region: YbbR; pfam07949 1327988002017 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1327988002018 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1327988002019 active site 1327988002020 substrate binding site [chemical binding]; other site 1327988002021 metal binding site [ion binding]; metal-binding site 1327988002022 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1327988002023 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1327988002024 glutaminase active site [active] 1327988002025 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1327988002026 dimer interface [polypeptide binding]; other site 1327988002027 active site 1327988002028 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1327988002029 dimer interface [polypeptide binding]; other site 1327988002030 active site 1327988002031 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1327988002032 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1327988002033 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988002034 active site 1327988002035 motif I; other site 1327988002036 motif II; other site 1327988002037 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1327988002038 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988002039 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1327988002040 active site 1327988002041 catalytic residues [active] 1327988002042 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1327988002043 dimer interface [polypeptide binding]; other site 1327988002044 FMN binding site [chemical binding]; other site 1327988002045 NADPH bind site [chemical binding]; other site 1327988002046 H+ Antiporter protein; Region: 2A0121; TIGR00900 1327988002047 glycerol kinase; Provisional; Region: glpK; PRK00047 1327988002048 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1327988002049 N- and C-terminal domain interface [polypeptide binding]; other site 1327988002050 active site 1327988002051 MgATP binding site [chemical binding]; other site 1327988002052 catalytic site [active] 1327988002053 metal binding site [ion binding]; metal-binding site 1327988002054 glycerol binding site [chemical binding]; other site 1327988002055 homotetramer interface [polypeptide binding]; other site 1327988002056 homodimer interface [polypeptide binding]; other site 1327988002057 FBP binding site [chemical binding]; other site 1327988002058 protein IIAGlc interface [polypeptide binding]; other site 1327988002059 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1327988002060 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1327988002061 putative catalytic residues [active] 1327988002062 thiol/disulfide switch; other site 1327988002063 ArsC family; Region: ArsC; pfam03960 1327988002064 VanZ like family; Region: VanZ; cl01971 1327988002065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988002066 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988002067 putative substrate translocation pore; other site 1327988002068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988002069 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1327988002070 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1327988002071 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1327988002072 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 1327988002073 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1327988002074 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1327988002075 putative domain interface [polypeptide binding]; other site 1327988002076 putative active site [active] 1327988002077 catalytic site [active] 1327988002078 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1327988002079 putative domain interface [polypeptide binding]; other site 1327988002080 putative active site [active] 1327988002081 catalytic site [active] 1327988002082 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1327988002083 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1327988002084 Zn2+ binding site [ion binding]; other site 1327988002085 Mg2+ binding site [ion binding]; other site 1327988002086 LicD family; Region: LicD; pfam04991 1327988002087 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1327988002088 MarR family; Region: MarR_2; pfam12802 1327988002089 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1327988002090 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 1327988002091 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1327988002092 PYR/PP interface [polypeptide binding]; other site 1327988002093 dimer interface [polypeptide binding]; other site 1327988002094 tetramer interface [polypeptide binding]; other site 1327988002095 TPP binding site [chemical binding]; other site 1327988002096 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1327988002097 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1327988002098 TPP-binding site [chemical binding]; other site 1327988002099 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1327988002100 active site 1327988002101 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 1327988002102 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1327988002103 PYR/PP interface [polypeptide binding]; other site 1327988002104 dimer interface [polypeptide binding]; other site 1327988002105 tetramer interface [polypeptide binding]; other site 1327988002106 TPP binding site [chemical binding]; other site 1327988002107 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1327988002108 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1327988002109 TPP-binding site [chemical binding]; other site 1327988002110 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1327988002111 recA bacterial DNA recombination protein; Region: RecA; cl17211 1327988002112 TAP-like protein; Region: Abhydrolase_4; pfam08386 1327988002113 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1327988002114 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1327988002115 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1327988002116 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1327988002117 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1327988002118 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1327988002119 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1327988002120 catalytic triad [active] 1327988002121 catalytic triad [active] 1327988002122 oxyanion hole [active] 1327988002123 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1327988002124 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 1327988002125 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1327988002126 OsmC-like protein; Region: OsmC; cl00767 1327988002127 amino acid transporter; Region: 2A0306; TIGR00909 1327988002128 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1327988002129 AP2 domain; Region: AP2; pfam00847 1327988002130 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1327988002131 substrate binding site [chemical binding]; other site 1327988002132 ATP binding site [chemical binding]; other site 1327988002133 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 1327988002134 active site 1327988002135 Ap4A binding cleft/pocket [chemical binding]; other site 1327988002136 P4 phosphate binding site; other site 1327988002137 nudix motif; other site 1327988002138 putative P2/P3 phosphate binding site [ion binding]; other site 1327988002139 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1327988002140 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1327988002141 catalytic site [active] 1327988002142 G-X2-G-X-G-K; other site 1327988002143 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1327988002144 metal binding site 2 [ion binding]; metal-binding site 1327988002145 putative DNA binding helix; other site 1327988002146 metal binding site 1 [ion binding]; metal-binding site 1327988002147 dimer interface [polypeptide binding]; other site 1327988002148 structural Zn2+ binding site [ion binding]; other site 1327988002149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1327988002150 Helix-turn-helix domain; Region: HTH_28; pfam13518 1327988002151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1327988002152 Helix-turn-helix domain; Region: HTH_28; pfam13518 1327988002153 putative transposase OrfB; Reviewed; Region: PHA02517 1327988002154 HTH-like domain; Region: HTH_21; pfam13276 1327988002155 Integrase core domain; Region: rve; pfam00665 1327988002156 Integrase core domain; Region: rve_2; pfam13333 1327988002157 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1327988002158 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988002159 motif II; other site 1327988002160 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1327988002161 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1327988002162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988002163 homodimer interface [polypeptide binding]; other site 1327988002164 catalytic residue [active] 1327988002165 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1327988002166 D-lactate dehydrogenase; Validated; Region: PRK08605 1327988002167 homodimer interface [polypeptide binding]; other site 1327988002168 ligand binding site [chemical binding]; other site 1327988002169 NAD binding site [chemical binding]; other site 1327988002170 catalytic site [active] 1327988002171 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1327988002172 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1327988002173 Walker A/P-loop; other site 1327988002174 ATP binding site [chemical binding]; other site 1327988002175 Q-loop/lid; other site 1327988002176 ABC transporter signature motif; other site 1327988002177 Walker B; other site 1327988002178 D-loop; other site 1327988002179 H-loop/switch region; other site 1327988002180 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1327988002181 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1327988002182 substrate binding pocket [chemical binding]; other site 1327988002183 membrane-bound complex binding site; other site 1327988002184 hinge residues; other site 1327988002185 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1327988002186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988002187 dimer interface [polypeptide binding]; other site 1327988002188 conserved gate region; other site 1327988002189 putative PBP binding loops; other site 1327988002190 ABC-ATPase subunit interface; other site 1327988002191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988002192 dimer interface [polypeptide binding]; other site 1327988002193 conserved gate region; other site 1327988002194 putative PBP binding loops; other site 1327988002195 ABC-ATPase subunit interface; other site 1327988002196 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1327988002197 HPr interaction site; other site 1327988002198 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1327988002199 active site 1327988002200 phosphorylation site [posttranslational modification] 1327988002201 CAT RNA binding domain; Region: CAT_RBD; smart01061 1327988002202 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1327988002203 PRD domain; Region: PRD; pfam00874 1327988002204 PRD domain; Region: PRD; pfam00874 1327988002205 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1327988002206 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1327988002207 active site turn [active] 1327988002208 phosphorylation site [posttranslational modification] 1327988002209 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1327988002210 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 1327988002211 putative active site [active] 1327988002212 YdjC motif; other site 1327988002213 Mg binding site [ion binding]; other site 1327988002214 putative homodimer interface [polypeptide binding]; other site 1327988002215 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1327988002216 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1327988002217 MarR family; Region: MarR; pfam01047 1327988002218 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1327988002219 MarR family; Region: MarR_2; pfam12802 1327988002220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988002221 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988002222 putative substrate translocation pore; other site 1327988002223 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1327988002224 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988002225 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988002226 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1327988002227 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1327988002228 HflX GTPase family; Region: HflX; cd01878 1327988002229 G1 box; other site 1327988002230 GTP/Mg2+ binding site [chemical binding]; other site 1327988002231 Switch I region; other site 1327988002232 G2 box; other site 1327988002233 G3 box; other site 1327988002234 Switch II region; other site 1327988002235 G4 box; other site 1327988002236 G5 box; other site 1327988002237 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1327988002238 nudix motif; other site 1327988002239 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1327988002240 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1327988002241 catalytic core [active] 1327988002242 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1327988002243 catalytic core [active] 1327988002244 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1327988002245 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1327988002246 TrkA-N domain; Region: TrkA_N; pfam02254 1327988002247 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1327988002248 TrkA-C domain; Region: TrkA_C; pfam02080 1327988002249 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 1327988002250 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1327988002251 putative active site [active] 1327988002252 nucleotide binding site [chemical binding]; other site 1327988002253 nudix motif; other site 1327988002254 putative metal binding site [ion binding]; other site 1327988002255 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1327988002256 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1327988002257 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1327988002258 Part of AAA domain; Region: AAA_19; pfam13245 1327988002259 Family description; Region: UvrD_C_2; pfam13538 1327988002260 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1327988002261 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1327988002262 FMN binding site [chemical binding]; other site 1327988002263 substrate binding site [chemical binding]; other site 1327988002264 putative catalytic residue [active] 1327988002265 pantothenate kinase; Provisional; Region: PRK05439 1327988002266 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1327988002267 ATP-binding site [chemical binding]; other site 1327988002268 CoA-binding site [chemical binding]; other site 1327988002269 Mg2+-binding site [ion binding]; other site 1327988002270 GMP synthase; Reviewed; Region: guaA; PRK00074 1327988002271 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1327988002272 AMP/PPi binding site [chemical binding]; other site 1327988002273 candidate oxyanion hole; other site 1327988002274 catalytic triad [active] 1327988002275 potential glutamine specificity residues [chemical binding]; other site 1327988002276 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1327988002277 ATP Binding subdomain [chemical binding]; other site 1327988002278 Dimerization subdomain; other site 1327988002279 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988002280 Helix-turn-helix domain; Region: HTH_38; pfam13936 1327988002281 Integrase core domain; Region: rve; pfam00665 1327988002282 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1327988002283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988002284 Walker A motif; other site 1327988002285 ATP binding site [chemical binding]; other site 1327988002286 Walker B motif; other site 1327988002287 arginine finger; other site 1327988002288 Helix-turn-helix domain; Region: HTH_28; pfam13518 1327988002289 putative transposase OrfB; Reviewed; Region: PHA02517 1327988002290 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1327988002291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988002292 non-specific DNA binding site [nucleotide binding]; other site 1327988002293 salt bridge; other site 1327988002294 sequence-specific DNA binding site [nucleotide binding]; other site 1327988002295 CAAX protease self-immunity; Region: Abi; pfam02517 1327988002296 Predicted transcriptional regulators [Transcription]; Region: COG1733 1327988002297 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1327988002298 Helix-turn-helix domain; Region: HTH_28; pfam13518 1327988002299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1327988002300 Transposase; Region: HTH_Tnp_1; cl17663 1327988002301 Helix-turn-helix domain; Region: HTH_28; pfam13518 1327988002302 putative transposase OrfB; Reviewed; Region: PHA02517 1327988002303 HTH-like domain; Region: HTH_21; pfam13276 1327988002304 Integrase core domain; Region: rve; pfam00665 1327988002305 Integrase core domain; Region: rve_3; pfam13683 1327988002306 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1327988002307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988002308 putative substrate translocation pore; other site 1327988002309 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1327988002310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1327988002311 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1327988002312 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1327988002313 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1327988002314 catalytic triad [active] 1327988002315 catalytic triad [active] 1327988002316 oxyanion hole [active] 1327988002317 Predicted membrane protein [Function unknown]; Region: COG2261 1327988002318 Asp23 family; Region: Asp23; pfam03780 1327988002319 Asp23 family; Region: Asp23; pfam03780 1327988002320 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1327988002321 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1327988002322 Peptidase family M1; Region: Peptidase_M1; pfam01433 1327988002323 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1327988002324 Zn binding site [ion binding]; other site 1327988002325 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 1327988002326 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1327988002327 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1327988002328 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1327988002329 ATP binding site [chemical binding]; other site 1327988002330 putative Mg++ binding site [ion binding]; other site 1327988002331 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 1327988002332 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1327988002333 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1327988002334 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1327988002335 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1327988002336 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988002337 Helix-turn-helix domain; Region: HTH_38; pfam13936 1327988002338 Integrase core domain; Region: rve; pfam00665 1327988002339 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1327988002340 Int/Topo IB signature motif; other site 1327988002341 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1327988002342 MULE transposase domain; Region: MULE; pfam10551 1327988002343 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1327988002344 catalytic core [active] 1327988002345 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1327988002346 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988002347 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988002348 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988002349 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988002350 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988002351 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988002352 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988002353 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988002354 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988002355 hypothetical protein; Provisional; Region: PRK06762 1327988002356 AAA domain; Region: AAA_33; pfam13671 1327988002357 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988002358 non-specific DNA binding site [nucleotide binding]; other site 1327988002359 salt bridge; other site 1327988002360 sequence-specific DNA binding site [nucleotide binding]; other site 1327988002361 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1327988002362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988002363 non-specific DNA binding site [nucleotide binding]; other site 1327988002364 salt bridge; other site 1327988002365 sequence-specific DNA binding site [nucleotide binding]; other site 1327988002366 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1327988002367 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988002368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1327988002369 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1327988002370 dimerization interface [polypeptide binding]; other site 1327988002371 FAD binding domain; Region: FAD_binding_2; pfam00890 1327988002372 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1327988002373 FMN-binding domain; Region: FMN_bind; cl01081 1327988002374 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1327988002375 MarR family; Region: MarR_2; cl17246 1327988002376 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1327988002377 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1327988002378 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1327988002379 putative dimer interface [polypeptide binding]; other site 1327988002380 putative anticodon binding site; other site 1327988002381 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1327988002382 homodimer interface [polypeptide binding]; other site 1327988002383 motif 1; other site 1327988002384 motif 2; other site 1327988002385 active site 1327988002386 motif 3; other site 1327988002387 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1327988002388 dimer interface [polypeptide binding]; other site 1327988002389 active site 1327988002390 Peptidase family C69; Region: Peptidase_C69; pfam03577 1327988002391 Helix-turn-helix domain; Region: HTH_28; pfam13518 1327988002392 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1327988002393 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1327988002394 ATP binding site [chemical binding]; other site 1327988002395 putative Mg++ binding site [ion binding]; other site 1327988002396 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1327988002397 nucleotide binding region [chemical binding]; other site 1327988002398 ATP-binding site [chemical binding]; other site 1327988002399 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1327988002400 HRDC domain; Region: HRDC; pfam00570 1327988002401 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1327988002402 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1327988002403 active site 1327988002404 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1327988002405 dimerization interface [polypeptide binding]; other site 1327988002406 putative DNA binding site [nucleotide binding]; other site 1327988002407 putative Zn2+ binding site [ion binding]; other site 1327988002408 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1327988002409 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1327988002410 YibE/F-like protein; Region: YibE_F; pfam07907 1327988002411 YibE/F-like protein; Region: YibE_F; pfam07907 1327988002412 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1327988002413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1327988002414 Coenzyme A binding pocket [chemical binding]; other site 1327988002415 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1327988002416 catalytic core [active] 1327988002417 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1327988002418 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1327988002419 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1327988002420 MFS/sugar transport protein; Region: MFS_2; pfam13347 1327988002421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988002422 putative substrate translocation pore; other site 1327988002423 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1327988002424 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1327988002425 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1327988002426 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1327988002427 aspartate kinase I; Reviewed; Region: PRK08210 1327988002428 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 1327988002429 putative catalytic residues [active] 1327988002430 putative nucleotide binding site [chemical binding]; other site 1327988002431 putative aspartate binding site [chemical binding]; other site 1327988002432 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1327988002433 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1327988002434 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1327988002435 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1327988002436 active site 1327988002437 dimer interface [polypeptide binding]; other site 1327988002438 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1327988002439 Ligand Binding Site [chemical binding]; other site 1327988002440 Molecular Tunnel; other site 1327988002441 Predicted membrane protein [Function unknown]; Region: COG4392 1327988002442 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1327988002443 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1327988002444 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1327988002445 DNA binding residues [nucleotide binding] 1327988002446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988002447 putative substrate translocation pore; other site 1327988002448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988002449 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1327988002450 DNA binding residues [nucleotide binding] 1327988002451 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1327988002452 putative dimer interface [polypeptide binding]; other site 1327988002453 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1327988002454 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1327988002455 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1327988002456 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1327988002457 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1327988002458 DNA-binding site [nucleotide binding]; DNA binding site 1327988002459 RNA-binding motif; other site 1327988002460 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1327988002461 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1327988002462 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1327988002463 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1327988002464 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1327988002465 active site 1327988002466 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1327988002467 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1327988002468 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1327988002469 Predicted transcriptional regulator [Transcription]; Region: COG1959 1327988002470 Transcriptional regulator; Region: Rrf2; pfam02082 1327988002471 acetolactate synthase; Reviewed; Region: PRK08617 1327988002472 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1327988002473 PYR/PP interface [polypeptide binding]; other site 1327988002474 dimer interface [polypeptide binding]; other site 1327988002475 TPP binding site [chemical binding]; other site 1327988002476 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1327988002477 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1327988002478 TPP-binding site [chemical binding]; other site 1327988002479 dimer interface [polypeptide binding]; other site 1327988002480 lysine transporter; Provisional; Region: PRK10836 1327988002481 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1327988002482 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1327988002483 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1327988002484 Substrate-binding site [chemical binding]; other site 1327988002485 Substrate specificity [chemical binding]; other site 1327988002486 seryl-tRNA synthetase; Provisional; Region: PRK05431 1327988002487 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1327988002488 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1327988002489 dimer interface [polypeptide binding]; other site 1327988002490 active site 1327988002491 motif 1; other site 1327988002492 motif 2; other site 1327988002493 motif 3; other site 1327988002494 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1327988002495 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1327988002496 Clp amino terminal domain; Region: Clp_N; pfam02861 1327988002497 Clp amino terminal domain; Region: Clp_N; pfam02861 1327988002498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988002499 Walker A motif; other site 1327988002500 ATP binding site [chemical binding]; other site 1327988002501 Walker B motif; other site 1327988002502 arginine finger; other site 1327988002503 UvrB/uvrC motif; Region: UVR; pfam02151 1327988002504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988002505 Walker A motif; other site 1327988002506 ATP binding site [chemical binding]; other site 1327988002507 Walker B motif; other site 1327988002508 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1327988002509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988002510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988002511 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1327988002512 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1327988002513 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1327988002514 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1327988002515 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1327988002516 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1327988002517 RPB1 interaction site [polypeptide binding]; other site 1327988002518 RPB10 interaction site [polypeptide binding]; other site 1327988002519 RPB11 interaction site [polypeptide binding]; other site 1327988002520 RPB3 interaction site [polypeptide binding]; other site 1327988002521 RPB12 interaction site [polypeptide binding]; other site 1327988002522 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1327988002523 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1327988002524 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1327988002525 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1327988002526 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1327988002527 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1327988002528 cleft; other site 1327988002529 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 1327988002530 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1327988002531 DNA binding site [nucleotide binding] 1327988002532 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1327988002533 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1327988002534 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1327988002535 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1327988002536 S17 interaction site [polypeptide binding]; other site 1327988002537 S8 interaction site; other site 1327988002538 16S rRNA interaction site [nucleotide binding]; other site 1327988002539 streptomycin interaction site [chemical binding]; other site 1327988002540 23S rRNA interaction site [nucleotide binding]; other site 1327988002541 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1327988002542 30S ribosomal protein S7; Validated; Region: PRK05302 1327988002543 elongation factor G; Reviewed; Region: PRK12739 1327988002544 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1327988002545 G1 box; other site 1327988002546 putative GEF interaction site [polypeptide binding]; other site 1327988002547 GTP/Mg2+ binding site [chemical binding]; other site 1327988002548 Switch I region; other site 1327988002549 G2 box; other site 1327988002550 G3 box; other site 1327988002551 Switch II region; other site 1327988002552 G4 box; other site 1327988002553 G5 box; other site 1327988002554 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1327988002555 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1327988002556 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1327988002557 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1327988002558 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1327988002559 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1327988002560 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1327988002561 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1327988002562 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1327988002563 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1327988002564 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1327988002565 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1327988002566 putative translocon binding site; other site 1327988002567 protein-rRNA interface [nucleotide binding]; other site 1327988002568 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1327988002569 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1327988002570 G-X-X-G motif; other site 1327988002571 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1327988002572 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1327988002573 23S rRNA interface [nucleotide binding]; other site 1327988002574 5S rRNA interface [nucleotide binding]; other site 1327988002575 putative antibiotic binding site [chemical binding]; other site 1327988002576 L25 interface [polypeptide binding]; other site 1327988002577 L27 interface [polypeptide binding]; other site 1327988002578 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1327988002579 23S rRNA interface [nucleotide binding]; other site 1327988002580 putative translocon interaction site; other site 1327988002581 signal recognition particle (SRP54) interaction site; other site 1327988002582 L23 interface [polypeptide binding]; other site 1327988002583 trigger factor interaction site; other site 1327988002584 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1327988002585 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1327988002586 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1327988002587 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1327988002588 RNA binding site [nucleotide binding]; other site 1327988002589 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1327988002590 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1327988002591 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1327988002592 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1327988002593 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1327988002594 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1327988002595 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1327988002596 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1327988002597 5S rRNA interface [nucleotide binding]; other site 1327988002598 L27 interface [polypeptide binding]; other site 1327988002599 23S rRNA interface [nucleotide binding]; other site 1327988002600 L5 interface [polypeptide binding]; other site 1327988002601 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1327988002602 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1327988002603 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1327988002604 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1327988002605 23S rRNA binding site [nucleotide binding]; other site 1327988002606 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1327988002607 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1327988002608 SecY translocase; Region: SecY; pfam00344 1327988002609 adenylate kinase; Reviewed; Region: adk; PRK00279 1327988002610 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1327988002611 AMP-binding site [chemical binding]; other site 1327988002612 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1327988002613 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1327988002614 rRNA binding site [nucleotide binding]; other site 1327988002615 predicted 30S ribosome binding site; other site 1327988002616 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1327988002617 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1327988002618 30S ribosomal protein S11; Validated; Region: PRK05309 1327988002619 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1327988002620 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1327988002621 alphaNTD homodimer interface [polypeptide binding]; other site 1327988002622 alphaNTD - beta interaction site [polypeptide binding]; other site 1327988002623 alphaNTD - beta' interaction site [polypeptide binding]; other site 1327988002624 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1327988002625 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1327988002626 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1327988002627 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1327988002628 substrate binding pocket [chemical binding]; other site 1327988002629 chain length determination region; other site 1327988002630 substrate-Mg2+ binding site; other site 1327988002631 catalytic residues [active] 1327988002632 aspartate-rich region 1; other site 1327988002633 active site lid residues [active] 1327988002634 aspartate-rich region 2; other site 1327988002635 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 1327988002636 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 1327988002637 trimer interface [polypeptide binding]; other site 1327988002638 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1327988002639 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1327988002640 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 1327988002641 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 1327988002642 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1327988002643 ApbE family; Region: ApbE; pfam02424 1327988002644 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1327988002645 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1327988002646 Walker A/P-loop; other site 1327988002647 ATP binding site [chemical binding]; other site 1327988002648 Q-loop/lid; other site 1327988002649 ABC transporter signature motif; other site 1327988002650 Walker B; other site 1327988002651 D-loop; other site 1327988002652 H-loop/switch region; other site 1327988002653 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1327988002654 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1327988002655 Walker A/P-loop; other site 1327988002656 ATP binding site [chemical binding]; other site 1327988002657 Q-loop/lid; other site 1327988002658 ABC transporter signature motif; other site 1327988002659 Walker B; other site 1327988002660 D-loop; other site 1327988002661 H-loop/switch region; other site 1327988002662 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1327988002663 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1327988002664 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1327988002665 dimerization interface 3.5A [polypeptide binding]; other site 1327988002666 active site 1327988002667 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1327988002668 23S rRNA interface [nucleotide binding]; other site 1327988002669 L3 interface [polypeptide binding]; other site 1327988002670 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1327988002671 EDD domain protein, DegV family; Region: DegV; TIGR00762 1327988002672 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1327988002673 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1327988002674 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1327988002675 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1327988002676 TPP-binding site [chemical binding]; other site 1327988002677 dimer interface [polypeptide binding]; other site 1327988002678 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1327988002679 PYR/PP interface [polypeptide binding]; other site 1327988002680 dimer interface [polypeptide binding]; other site 1327988002681 TPP binding site [chemical binding]; other site 1327988002682 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1327988002683 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1327988002684 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1327988002685 shikimate binding site; other site 1327988002686 NAD(P) binding site [chemical binding]; other site 1327988002687 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1327988002688 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1327988002689 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1327988002690 active site 1327988002691 dimer interface [polypeptide binding]; other site 1327988002692 metal binding site [ion binding]; metal-binding site 1327988002693 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1327988002694 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1327988002695 transmembrane helices; other site 1327988002696 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1327988002697 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 1327988002698 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 1327988002699 Cupin domain; Region: Cupin_2; pfam07883 1327988002700 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1327988002701 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 1327988002702 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1327988002703 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1327988002704 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1327988002705 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1327988002706 ABC-ATPase subunit interface; other site 1327988002707 dimer interface [polypeptide binding]; other site 1327988002708 putative PBP binding regions; other site 1327988002709 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1327988002710 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1327988002711 metal binding site [ion binding]; metal-binding site 1327988002712 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1327988002713 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1327988002714 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1327988002715 NAD binding site [chemical binding]; other site 1327988002716 dimer interface [polypeptide binding]; other site 1327988002717 substrate binding site [chemical binding]; other site 1327988002718 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1327988002719 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1327988002720 transmembrane helices; other site 1327988002721 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1327988002722 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1327988002723 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1327988002724 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1327988002725 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 1327988002726 NAD(P) binding pocket [chemical binding]; other site 1327988002727 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 1327988002728 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1327988002729 putative active site [active] 1327988002730 (T/H)XGH motif; other site 1327988002731 citrate lyase subunit gamma; Provisional; Region: PRK13253 1327988002732 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1327988002733 citrate lyase, alpha subunit; Region: citF; TIGR01584 1327988002734 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1327988002735 Class II fumarases; Region: Fumarase_classII; cd01362 1327988002736 active site 1327988002737 tetramer interface [polypeptide binding]; other site 1327988002738 L-aspartate oxidase; Provisional; Region: PRK06175 1327988002739 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1327988002740 L-aspartate oxidase; Provisional; Region: PRK06175 1327988002741 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 1327988002742 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988002743 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1327988002744 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1327988002745 dimerization interface [polypeptide binding]; other site 1327988002746 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988002747 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1327988002748 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1327988002749 dimerization interface [polypeptide binding]; other site 1327988002750 malate dehydrogenase; Provisional; Region: PRK13529 1327988002751 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1327988002752 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1327988002753 NAD(P) binding site [chemical binding]; other site 1327988002754 Membrane transport protein; Region: Mem_trans; cl09117 1327988002755 amino acid transporter; Region: 2A0306; TIGR00909 1327988002756 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1327988002757 Predicted membrane protein [Function unknown]; Region: COG4684 1327988002758 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1327988002759 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1327988002760 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1327988002761 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1327988002762 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1327988002763 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1327988002764 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1327988002765 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1327988002766 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1327988002767 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988002768 Walker A/P-loop; other site 1327988002769 ATP binding site [chemical binding]; other site 1327988002770 Q-loop/lid; other site 1327988002771 ABC transporter signature motif; other site 1327988002772 Walker B; other site 1327988002773 D-loop; other site 1327988002774 H-loop/switch region; other site 1327988002775 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1327988002776 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1327988002777 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1327988002778 Walker A/P-loop; other site 1327988002779 ATP binding site [chemical binding]; other site 1327988002780 Q-loop/lid; other site 1327988002781 ABC transporter signature motif; other site 1327988002782 Walker B; other site 1327988002783 D-loop; other site 1327988002784 H-loop/switch region; other site 1327988002785 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1327988002786 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1327988002787 substrate binding pocket [chemical binding]; other site 1327988002788 chain length determination region; other site 1327988002789 substrate-Mg2+ binding site; other site 1327988002790 catalytic residues [active] 1327988002791 aspartate-rich region 1; other site 1327988002792 active site lid residues [active] 1327988002793 aspartate-rich region 2; other site 1327988002794 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1327988002795 UbiA prenyltransferase family; Region: UbiA; pfam01040 1327988002796 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1327988002797 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1327988002798 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1327988002799 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1327988002800 active site 1327988002801 hypothetical protein; Provisional; Region: PRK04164 1327988002802 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1327988002803 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1327988002804 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1327988002805 Part of AAA domain; Region: AAA_19; pfam13245 1327988002806 Family description; Region: UvrD_C_2; pfam13538 1327988002807 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1327988002808 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1327988002809 nucleotide binding pocket [chemical binding]; other site 1327988002810 K-X-D-G motif; other site 1327988002811 catalytic site [active] 1327988002812 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1327988002813 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1327988002814 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1327988002815 Dimer interface [polypeptide binding]; other site 1327988002816 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1327988002817 putative dimer interface [polypeptide binding]; other site 1327988002818 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 1327988002819 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1327988002820 putative dimer interface [polypeptide binding]; other site 1327988002821 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1327988002822 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1327988002823 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1327988002824 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1327988002825 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1327988002826 GatB domain; Region: GatB_Yqey; pfam02637 1327988002827 putative lipid kinase; Reviewed; Region: PRK13055 1327988002828 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1327988002829 TRAM domain; Region: TRAM; pfam01938 1327988002830 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1327988002831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1327988002832 S-adenosylmethionine binding site [chemical binding]; other site 1327988002833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988002834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988002835 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1327988002836 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1327988002837 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1327988002838 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1327988002839 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1327988002840 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1327988002841 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1327988002842 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1327988002843 putative active site [active] 1327988002844 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 1327988002845 active site 1327988002846 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1327988002847 DNA-binding site [nucleotide binding]; DNA binding site 1327988002848 RNA-binding motif; other site 1327988002849 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1327988002850 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1327988002851 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1327988002852 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1327988002853 ATP binding site [chemical binding]; other site 1327988002854 putative Mg++ binding site [ion binding]; other site 1327988002855 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1327988002856 nucleotide binding region [chemical binding]; other site 1327988002857 ATP-binding site [chemical binding]; other site 1327988002858 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1327988002859 Ligand Binding Site [chemical binding]; other site 1327988002860 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1327988002861 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1327988002862 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1327988002863 glutamate dehydrogenase; Provisional; Region: PRK09414 1327988002864 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1327988002865 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1327988002866 NAD(P) binding site [chemical binding]; other site 1327988002867 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1327988002868 Beta-lactamase; Region: Beta-lactamase; pfam00144 1327988002869 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1327988002870 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1327988002871 active site 1327988002872 homodimer interface [polypeptide binding]; other site 1327988002873 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1327988002874 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1327988002875 amphipathic channel; other site 1327988002876 Asn-Pro-Ala signature motifs; other site 1327988002877 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1327988002878 Helix-turn-helix domain; Region: HTH_28; pfam13518 1327988002879 putative transposase OrfB; Reviewed; Region: PHA02517 1327988002880 Integrase core domain; Region: rve; pfam00665 1327988002881 Integrase core domain; Region: rve_3; cl15866 1327988002882 putative transposase OrfB; Reviewed; Region: PHA02517 1327988002883 HTH-like domain; Region: HTH_21; pfam13276 1327988002884 Integrase core domain; Region: rve; pfam00665 1327988002885 Integrase core domain; Region: rve_3; pfam13683 1327988002886 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1327988002887 Transposase; Region: HTH_Tnp_1; pfam01527 1327988002888 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1327988002889 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1327988002890 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1327988002891 recombination regulator RecX; Provisional; Region: recX; PRK14135 1327988002892 hypothetical protein; Provisional; Region: PRK13662 1327988002893 NlpC/P60 family; Region: NLPC_P60; pfam00877 1327988002894 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1327988002895 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988002896 non-specific DNA binding site [nucleotide binding]; other site 1327988002897 salt bridge; other site 1327988002898 sequence-specific DNA binding site [nucleotide binding]; other site 1327988002899 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1327988002900 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1327988002901 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1327988002902 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1327988002903 NAD binding site [chemical binding]; other site 1327988002904 dimer interface [polypeptide binding]; other site 1327988002905 substrate binding site [chemical binding]; other site 1327988002906 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1327988002907 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1327988002908 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1327988002909 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1327988002910 active site 1327988002911 nucleotide binding site [chemical binding]; other site 1327988002912 HIGH motif; other site 1327988002913 KMSKS motif; other site 1327988002914 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1327988002915 GntP family permease; Region: GntP_permease; pfam02447 1327988002916 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1327988002917 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1327988002918 N- and C-terminal domain interface [polypeptide binding]; other site 1327988002919 active site 1327988002920 catalytic site [active] 1327988002921 metal binding site [ion binding]; metal-binding site 1327988002922 carbohydrate binding site [chemical binding]; other site 1327988002923 ATP binding site [chemical binding]; other site 1327988002924 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1327988002925 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1327988002926 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1327988002927 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1327988002928 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1327988002929 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1327988002930 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1327988002931 G1 box; other site 1327988002932 putative GEF interaction site [polypeptide binding]; other site 1327988002933 GTP/Mg2+ binding site [chemical binding]; other site 1327988002934 Switch I region; other site 1327988002935 G2 box; other site 1327988002936 G3 box; other site 1327988002937 Switch II region; other site 1327988002938 G4 box; other site 1327988002939 G5 box; other site 1327988002940 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1327988002941 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988002942 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988002943 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988002944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1327988002945 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1327988002946 dimerization interface [polypeptide binding]; other site 1327988002947 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1327988002948 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 1327988002949 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1327988002950 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1327988002951 peptide binding site [polypeptide binding]; other site 1327988002952 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1327988002953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988002954 dimer interface [polypeptide binding]; other site 1327988002955 conserved gate region; other site 1327988002956 putative PBP binding loops; other site 1327988002957 ABC-ATPase subunit interface; other site 1327988002958 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1327988002959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988002960 dimer interface [polypeptide binding]; other site 1327988002961 conserved gate region; other site 1327988002962 putative PBP binding loops; other site 1327988002963 ABC-ATPase subunit interface; other site 1327988002964 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1327988002965 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1327988002966 Walker A/P-loop; other site 1327988002967 ATP binding site [chemical binding]; other site 1327988002968 Q-loop/lid; other site 1327988002969 ABC transporter signature motif; other site 1327988002970 Walker B; other site 1327988002971 D-loop; other site 1327988002972 H-loop/switch region; other site 1327988002973 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1327988002974 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1327988002975 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1327988002976 Walker A/P-loop; other site 1327988002977 ATP binding site [chemical binding]; other site 1327988002978 Q-loop/lid; other site 1327988002979 ABC transporter signature motif; other site 1327988002980 Walker B; other site 1327988002981 D-loop; other site 1327988002982 H-loop/switch region; other site 1327988002983 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1327988002984 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1327988002985 MarR family; Region: MarR_2; pfam12802 1327988002986 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1327988002987 Int/Topo IB signature motif; other site 1327988002988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988002989 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1327988002990 Walker A motif; other site 1327988002991 ATP binding site [chemical binding]; other site 1327988002992 Walker B motif; other site 1327988002993 arginine finger; other site 1327988002994 UvrB/uvrC motif; Region: UVR; pfam02151 1327988002995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988002996 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1327988002997 Walker A motif; other site 1327988002998 ATP binding site [chemical binding]; other site 1327988002999 Walker B motif; other site 1327988003000 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1327988003001 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1327988003002 dimerization domain swap beta strand [polypeptide binding]; other site 1327988003003 regulatory protein interface [polypeptide binding]; other site 1327988003004 active site 1327988003005 regulatory phosphorylation site [posttranslational modification]; other site 1327988003006 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1327988003007 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1327988003008 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1327988003009 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1327988003010 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1327988003011 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1327988003012 putative ADP-binding pocket [chemical binding]; other site 1327988003013 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1327988003014 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1327988003015 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1327988003016 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1327988003017 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1327988003018 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1327988003019 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1327988003020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988003021 homodimer interface [polypeptide binding]; other site 1327988003022 catalytic residue [active] 1327988003023 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 1327988003024 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1327988003025 Sulfatase; Region: Sulfatase; pfam00884 1327988003026 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1327988003027 active site 1327988003028 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1327988003029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1327988003030 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1327988003031 Coenzyme A binding pocket [chemical binding]; other site 1327988003032 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1327988003033 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1327988003034 active site 1327988003035 metal binding site [ion binding]; metal-binding site 1327988003036 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1327988003037 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1327988003038 Ferrochelatase; Region: Ferrochelatase; pfam00762 1327988003039 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1327988003040 C-terminal domain interface [polypeptide binding]; other site 1327988003041 active site 1327988003042 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1327988003043 active site 1327988003044 N-terminal domain interface [polypeptide binding]; other site 1327988003045 S-methylmethionine transporter; Provisional; Region: PRK11387 1327988003046 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1327988003047 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1327988003048 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1327988003049 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1327988003050 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1327988003051 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1327988003052 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1327988003053 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1327988003054 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1327988003055 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1327988003056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988003057 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988003058 putative substrate translocation pore; other site 1327988003059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988003060 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1327988003061 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1327988003062 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1327988003063 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1327988003064 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1327988003065 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1327988003066 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1327988003067 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1327988003068 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1327988003069 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1327988003070 active site 1327988003071 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1327988003072 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1327988003073 HIGH motif; other site 1327988003074 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1327988003075 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1327988003076 active site 1327988003077 KMSKS motif; other site 1327988003078 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1327988003079 tRNA binding surface [nucleotide binding]; other site 1327988003080 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1327988003081 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1327988003082 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1327988003083 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1327988003084 RNA binding surface [nucleotide binding]; other site 1327988003085 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1327988003086 active site 1327988003087 uracil binding [chemical binding]; other site 1327988003088 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1327988003089 putative substrate binding site [chemical binding]; other site 1327988003090 putative ATP binding site [chemical binding]; other site 1327988003091 dipeptidase PepV; Reviewed; Region: PRK07318 1327988003092 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1327988003093 active site 1327988003094 metal binding site [ion binding]; metal-binding site 1327988003095 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1327988003096 Ligand Binding Site [chemical binding]; other site 1327988003097 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1327988003098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988003099 Walker A/P-loop; other site 1327988003100 ATP binding site [chemical binding]; other site 1327988003101 Q-loop/lid; other site 1327988003102 ABC transporter signature motif; other site 1327988003103 Walker B; other site 1327988003104 D-loop; other site 1327988003105 H-loop/switch region; other site 1327988003106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988003107 dimer interface [polypeptide binding]; other site 1327988003108 conserved gate region; other site 1327988003109 putative PBP binding loops; other site 1327988003110 ABC-ATPase subunit interface; other site 1327988003111 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1327988003112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988003113 dimer interface [polypeptide binding]; other site 1327988003114 conserved gate region; other site 1327988003115 putative PBP binding loops; other site 1327988003116 ABC-ATPase subunit interface; other site 1327988003117 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1327988003118 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1327988003119 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1327988003120 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1327988003121 active site 1327988003122 catalytic site [active] 1327988003123 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1327988003124 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1327988003125 Substrate-binding site [chemical binding]; other site 1327988003126 Substrate specificity [chemical binding]; other site 1327988003127 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1327988003128 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1327988003129 Predicted membrane protein [Function unknown]; Region: COG1511 1327988003130 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1327988003131 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1327988003132 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1327988003133 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1327988003134 Walker A/P-loop; other site 1327988003135 ATP binding site [chemical binding]; other site 1327988003136 Q-loop/lid; other site 1327988003137 ABC transporter signature motif; other site 1327988003138 Walker B; other site 1327988003139 D-loop; other site 1327988003140 H-loop/switch region; other site 1327988003141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988003142 Walker A/P-loop; other site 1327988003143 ATP binding site [chemical binding]; other site 1327988003144 ABC transporter; Region: ABC_tran; pfam00005 1327988003145 Q-loop/lid; other site 1327988003146 ABC transporter signature motif; other site 1327988003147 Walker B; other site 1327988003148 D-loop; other site 1327988003149 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1327988003150 H-loop/switch region; other site 1327988003151 LytTr DNA-binding domain; Region: LytTR; pfam04397 1327988003152 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1327988003153 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1327988003154 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1327988003155 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1327988003156 DNA binding residues [nucleotide binding] 1327988003157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1327988003158 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1327988003159 NAD(P) binding site [chemical binding]; other site 1327988003160 active site 1327988003161 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1327988003162 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1327988003163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1327988003164 active site 1327988003165 motif I; other site 1327988003166 motif II; other site 1327988003167 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1327988003168 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1327988003169 ATP binding site [chemical binding]; other site 1327988003170 Mg2+ binding site [ion binding]; other site 1327988003171 G-X-G motif; other site 1327988003172 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1327988003173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1327988003174 active site 1327988003175 phosphorylation site [posttranslational modification] 1327988003176 intermolecular recognition site; other site 1327988003177 dimerization interface [polypeptide binding]; other site 1327988003178 LytTr DNA-binding domain; Region: LytTR; pfam04397 1327988003179 CAAX protease self-immunity; Region: Abi; pfam02517 1327988003180 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1327988003181 MarR family; Region: MarR; pfam01047 1327988003182 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1327988003183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988003184 Walker A/P-loop; other site 1327988003185 ATP binding site [chemical binding]; other site 1327988003186 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1327988003187 Q-loop/lid; other site 1327988003188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988003189 ABC transporter signature motif; other site 1327988003190 Walker B; other site 1327988003191 D-loop; other site 1327988003192 H-loop/switch region; other site 1327988003193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988003194 Walker A/P-loop; other site 1327988003195 ATP binding site [chemical binding]; other site 1327988003196 Q-loop/lid; other site 1327988003197 ABC transporter signature motif; other site 1327988003198 Walker B; other site 1327988003199 D-loop; other site 1327988003200 H-loop/switch region; other site 1327988003201 Predicted membrane protein [Function unknown]; Region: COG2246 1327988003202 GtrA-like protein; Region: GtrA; pfam04138 1327988003203 hypothetical protein; Provisional; Region: PRK13673 1327988003204 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1327988003205 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1327988003206 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1327988003207 FAD binding site [chemical binding]; other site 1327988003208 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1327988003209 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1327988003210 THF binding site; other site 1327988003211 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1327988003212 substrate binding site [chemical binding]; other site 1327988003213 THF binding site; other site 1327988003214 zinc-binding site [ion binding]; other site 1327988003215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1327988003216 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1327988003217 ATP-sulfurylase; Region: ATPS; cd00517 1327988003218 active site 1327988003219 HXXH motif; other site 1327988003220 flexible loop; other site 1327988003221 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1327988003222 ligand-binding site [chemical binding]; other site 1327988003223 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1327988003224 DHH family; Region: DHH; pfam01368 1327988003225 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1327988003226 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1327988003227 TrkA-C domain; Region: TrkA_C; pfam02080 1327988003228 TrkA-C domain; Region: TrkA_C; pfam02080 1327988003229 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1327988003230 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1327988003231 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1327988003232 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1327988003233 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1327988003234 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1327988003235 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1327988003236 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1327988003237 active site 1327988003238 HIGH motif; other site 1327988003239 KMSK motif region; other site 1327988003240 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1327988003241 tRNA binding surface [nucleotide binding]; other site 1327988003242 anticodon binding site; other site 1327988003243 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1327988003244 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1327988003245 Walker A/P-loop; other site 1327988003246 ATP binding site [chemical binding]; other site 1327988003247 Q-loop/lid; other site 1327988003248 ABC transporter signature motif; other site 1327988003249 Walker B; other site 1327988003250 D-loop; other site 1327988003251 H-loop/switch region; other site 1327988003252 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1327988003253 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1327988003254 FtsX-like permease family; Region: FtsX; pfam02687 1327988003255 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1327988003256 Transcriptional antiterminator [Transcription]; Region: COG3933 1327988003257 PRD domain; Region: PRD; pfam00874 1327988003258 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 1327988003259 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 1327988003260 active site 1327988003261 methionine cluster; other site 1327988003262 phosphorylation site [posttranslational modification] 1327988003263 metal binding site [ion binding]; metal-binding site 1327988003264 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1327988003265 active site 1327988003266 P-loop; other site 1327988003267 phosphorylation site [posttranslational modification] 1327988003268 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1327988003269 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1327988003270 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1327988003271 beta-galactosidase; Region: BGL; TIGR03356 1327988003272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988003273 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988003274 putative substrate translocation pore; other site 1327988003275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1327988003276 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1327988003277 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1327988003278 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1327988003279 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1327988003280 DNA-binding site [nucleotide binding]; DNA binding site 1327988003281 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1327988003282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988003283 homodimer interface [polypeptide binding]; other site 1327988003284 catalytic residue [active] 1327988003285 LysE type translocator; Region: LysE; cl00565 1327988003286 transaminase; Validated; Region: PRK07324 1327988003287 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1327988003288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988003289 homodimer interface [polypeptide binding]; other site 1327988003290 catalytic residue [active] 1327988003291 Arginine repressor [Transcription]; Region: ArgR; COG1438 1327988003292 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1327988003293 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1327988003294 Transglycosylase; Region: Transgly; pfam00912 1327988003295 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1327988003296 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1327988003297 hypothetical protein; Provisional; Region: PRK13676 1327988003298 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1327988003299 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1327988003300 active site 1327988003301 metal binding site [ion binding]; metal-binding site 1327988003302 DNA binding site [nucleotide binding] 1327988003303 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1327988003304 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1327988003305 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1327988003306 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1327988003307 generic binding surface II; other site 1327988003308 generic binding surface I; other site 1327988003309 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1327988003310 Zn2+ binding site [ion binding]; other site 1327988003311 Mg2+ binding site [ion binding]; other site 1327988003312 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 1327988003313 Active site serine [active] 1327988003314 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988003315 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1327988003316 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1327988003317 dimerization interface [polypeptide binding]; other site 1327988003318 Predicted flavoprotein [General function prediction only]; Region: COG0431 1327988003319 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1327988003320 Predicted flavoprotein [General function prediction only]; Region: COG0431 1327988003321 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1327988003322 FMN-binding domain; Region: FMN_bind; cl01081 1327988003323 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 1327988003324 L-aspartate oxidase; Provisional; Region: PRK06175 1327988003325 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1327988003326 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1327988003327 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1327988003328 Ligand binding site; other site 1327988003329 Putative Catalytic site; other site 1327988003330 DXD motif; other site 1327988003331 conserved hypothetical integral membrane protein; Region: TIGR03766 1327988003332 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1327988003333 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1327988003334 catalytic motif [active] 1327988003335 Zn binding site [ion binding]; other site 1327988003336 RibD C-terminal domain; Region: RibD_C; cl17279 1327988003337 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1327988003338 Lumazine binding domain; Region: Lum_binding; pfam00677 1327988003339 Lumazine binding domain; Region: Lum_binding; pfam00677 1327988003340 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1327988003341 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1327988003342 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1327988003343 dimerization interface [polypeptide binding]; other site 1327988003344 active site 1327988003345 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1327988003346 homopentamer interface [polypeptide binding]; other site 1327988003347 active site 1327988003348 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 1327988003349 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1327988003350 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1327988003351 ligand binding site [chemical binding]; other site 1327988003352 flexible hinge region; other site 1327988003353 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1327988003354 non-specific DNA interactions [nucleotide binding]; other site 1327988003355 DNA binding site [nucleotide binding] 1327988003356 sequence specific DNA binding site [nucleotide binding]; other site 1327988003357 putative cAMP binding site [chemical binding]; other site 1327988003358 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988003359 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1327988003360 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1327988003361 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1327988003362 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1327988003363 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1327988003364 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1327988003365 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1327988003366 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1327988003367 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1327988003368 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1327988003369 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1327988003370 SurA N-terminal domain; Region: SurA_N; pfam09312 1327988003371 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1327988003372 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1327988003373 HIT family signature motif; other site 1327988003374 catalytic residue [active] 1327988003375 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1327988003376 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1327988003377 Walker A/P-loop; other site 1327988003378 ATP binding site [chemical binding]; other site 1327988003379 Q-loop/lid; other site 1327988003380 ABC transporter signature motif; other site 1327988003381 Walker B; other site 1327988003382 D-loop; other site 1327988003383 H-loop/switch region; other site 1327988003384 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1327988003385 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1327988003386 active site 1327988003387 substrate binding site [chemical binding]; other site 1327988003388 ATP binding site [chemical binding]; other site 1327988003389 Phosphotransferase enzyme family; Region: APH; pfam01636 1327988003390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1327988003391 S-adenosylmethionine binding site [chemical binding]; other site 1327988003392 Predicted small secreted protein [Function unknown]; Region: COG5584 1327988003393 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1327988003394 putative tRNA-binding site [nucleotide binding]; other site 1327988003395 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1327988003396 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1327988003397 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1327988003398 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1327988003399 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1327988003400 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1327988003401 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1327988003402 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1327988003403 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1327988003404 G1 box; other site 1327988003405 GTP/Mg2+ binding site [chemical binding]; other site 1327988003406 Switch I region; other site 1327988003407 G2 box; other site 1327988003408 G3 box; other site 1327988003409 Switch II region; other site 1327988003410 G4 box; other site 1327988003411 G5 box; other site 1327988003412 Nucleoside recognition; Region: Gate; pfam07670 1327988003413 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1327988003414 Nucleoside recognition; Region: Gate; pfam07670 1327988003415 FeoA domain; Region: FeoA; pfam04023 1327988003416 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1327988003417 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1327988003418 Walker A/P-loop; other site 1327988003419 ATP binding site [chemical binding]; other site 1327988003420 Q-loop/lid; other site 1327988003421 ABC transporter signature motif; other site 1327988003422 Walker B; other site 1327988003423 D-loop; other site 1327988003424 H-loop/switch region; other site 1327988003425 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1327988003426 FeS assembly protein SufD; Region: sufD; TIGR01981 1327988003427 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1327988003428 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1327988003429 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1327988003430 catalytic residue [active] 1327988003431 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1327988003432 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1327988003433 trimerization site [polypeptide binding]; other site 1327988003434 active site 1327988003435 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1327988003436 FeS assembly protein SufB; Region: sufB; TIGR01980 1327988003437 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1327988003438 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988003439 non-specific DNA binding site [nucleotide binding]; other site 1327988003440 salt bridge; other site 1327988003441 sequence-specific DNA binding site [nucleotide binding]; other site 1327988003442 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1327988003443 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1327988003444 DNA polymerase I; Provisional; Region: PRK05755 1327988003445 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1327988003446 active site 1327988003447 metal binding site 1 [ion binding]; metal-binding site 1327988003448 putative 5' ssDNA interaction site; other site 1327988003449 metal binding site 3; metal-binding site 1327988003450 metal binding site 2 [ion binding]; metal-binding site 1327988003451 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1327988003452 putative DNA binding site [nucleotide binding]; other site 1327988003453 putative metal binding site [ion binding]; other site 1327988003454 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1327988003455 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1327988003456 active site 1327988003457 DNA binding site [nucleotide binding] 1327988003458 catalytic site [active] 1327988003459 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1327988003460 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1327988003461 DNA binding site [nucleotide binding] 1327988003462 catalytic residue [active] 1327988003463 H2TH interface [polypeptide binding]; other site 1327988003464 putative catalytic residues [active] 1327988003465 turnover-facilitating residue; other site 1327988003466 intercalation triad [nucleotide binding]; other site 1327988003467 8OG recognition residue [nucleotide binding]; other site 1327988003468 putative reading head residues; other site 1327988003469 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1327988003470 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1327988003471 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1327988003472 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1327988003473 CoA-binding site [chemical binding]; other site 1327988003474 ATP-binding [chemical binding]; other site 1327988003475 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1327988003476 ATP cone domain; Region: ATP-cone; pfam03477 1327988003477 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1327988003478 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1327988003479 primosomal protein DnaI; Reviewed; Region: PRK08939 1327988003480 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1327988003481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988003482 Walker A motif; other site 1327988003483 ATP binding site [chemical binding]; other site 1327988003484 Walker B motif; other site 1327988003485 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1327988003486 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1327988003487 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1327988003488 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1327988003489 active site 1327988003490 dimer interface [polypeptide binding]; other site 1327988003491 motif 1; other site 1327988003492 motif 2; other site 1327988003493 motif 3; other site 1327988003494 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1327988003495 anticodon binding site; other site 1327988003496 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1327988003497 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1327988003498 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1327988003499 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1327988003500 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1327988003501 23S rRNA binding site [nucleotide binding]; other site 1327988003502 L21 binding site [polypeptide binding]; other site 1327988003503 L13 binding site [polypeptide binding]; other site 1327988003504 recombination factor protein RarA; Reviewed; Region: PRK13342 1327988003505 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988003506 Walker A motif; other site 1327988003507 ATP binding site [chemical binding]; other site 1327988003508 Walker B motif; other site 1327988003509 arginine finger; other site 1327988003510 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1327988003511 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1327988003512 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1327988003513 putative NAD(P) binding site [chemical binding]; other site 1327988003514 dimer interface [polypeptide binding]; other site 1327988003515 Predicted transcriptional regulators [Transcription]; Region: COG1733 1327988003516 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1327988003517 aspartate racemase; Region: asp_race; TIGR00035 1327988003518 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1327988003519 N-glycosyltransferase; Provisional; Region: PRK11204 1327988003520 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1327988003521 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1327988003522 DXD motif; other site 1327988003523 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1327988003524 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988003525 active site 1327988003526 motif I; other site 1327988003527 motif II; other site 1327988003528 GTPase YqeH; Provisional; Region: PRK13796 1327988003529 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1327988003530 GTP/Mg2+ binding site [chemical binding]; other site 1327988003531 G4 box; other site 1327988003532 G5 box; other site 1327988003533 G1 box; other site 1327988003534 Switch I region; other site 1327988003535 G2 box; other site 1327988003536 G3 box; other site 1327988003537 Switch II region; other site 1327988003538 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1327988003539 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1327988003540 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1327988003541 active site 1327988003542 (T/H)XGH motif; other site 1327988003543 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1327988003544 Zn2+ binding site [ion binding]; other site 1327988003545 Mg2+ binding site [ion binding]; other site 1327988003546 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1327988003547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1327988003548 S-adenosylmethionine binding site [chemical binding]; other site 1327988003549 hypothetical protein; Provisional; Region: PRK13670 1327988003550 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1327988003551 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1327988003552 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1327988003553 Predicted membrane protein [Function unknown]; Region: COG3212 1327988003554 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1327988003555 Cation efflux family; Region: Cation_efflux; pfam01545 1327988003556 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1327988003557 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1327988003558 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1327988003559 recombination factor protein RarA; Reviewed; Region: PRK13342 1327988003560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988003561 Walker A motif; other site 1327988003562 ATP binding site [chemical binding]; other site 1327988003563 Walker B motif; other site 1327988003564 arginine finger; other site 1327988003565 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1327988003566 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1327988003567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1327988003568 active site 1327988003569 phosphorylation site [posttranslational modification] 1327988003570 intermolecular recognition site; other site 1327988003571 dimerization interface [polypeptide binding]; other site 1327988003572 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1327988003573 DNA binding site [nucleotide binding] 1327988003574 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1327988003575 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1327988003576 dimerization interface [polypeptide binding]; other site 1327988003577 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1327988003578 dimer interface [polypeptide binding]; other site 1327988003579 phosphorylation site [posttranslational modification] 1327988003580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1327988003581 ATP binding site [chemical binding]; other site 1327988003582 Mg2+ binding site [ion binding]; other site 1327988003583 G-X-G motif; other site 1327988003584 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1327988003585 UbiA prenyltransferase family; Region: UbiA; pfam01040 1327988003586 exonuclease SbcC; Region: sbcc; TIGR00618 1327988003587 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1327988003588 Walker A/P-loop; other site 1327988003589 ATP binding site [chemical binding]; other site 1327988003590 Q-loop/lid; other site 1327988003591 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1327988003592 ABC transporter signature motif; other site 1327988003593 Walker B; other site 1327988003594 D-loop; other site 1327988003595 H-loop/switch region; other site 1327988003596 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1327988003597 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1327988003598 active site 1327988003599 metal binding site [ion binding]; metal-binding site 1327988003600 DNA binding site [nucleotide binding] 1327988003601 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1327988003602 SdpI/YhfL protein family; Region: SdpI; pfam13630 1327988003603 OxaA-like protein precursor; Provisional; Region: PRK02463 1327988003604 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1327988003605 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 1327988003606 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1327988003607 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1327988003608 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1327988003609 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1327988003610 Predicted transcriptional regulators [Transcription]; Region: COG1733 1327988003611 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1327988003612 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1327988003613 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1327988003614 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1327988003615 dimer interface [polypeptide binding]; other site 1327988003616 motif 1; other site 1327988003617 active site 1327988003618 motif 2; other site 1327988003619 motif 3; other site 1327988003620 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1327988003621 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1327988003622 putative tRNA-binding site [nucleotide binding]; other site 1327988003623 B3/4 domain; Region: B3_4; pfam03483 1327988003624 tRNA synthetase B5 domain; Region: B5; smart00874 1327988003625 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1327988003626 dimer interface [polypeptide binding]; other site 1327988003627 motif 1; other site 1327988003628 motif 3; other site 1327988003629 motif 2; other site 1327988003630 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1327988003631 YceG-like family; Region: YceG; pfam02618 1327988003632 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1327988003633 dimerization interface [polypeptide binding]; other site 1327988003634 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1327988003635 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1327988003636 Pyrimidine base specificity; other site 1327988003637 Sugar specificity; other site 1327988003638 ATP-binding site [chemical binding]; other site 1327988003639 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1327988003640 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1327988003641 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1327988003642 LytTr DNA-binding domain; Region: LytTR; pfam04397 1327988003643 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1327988003644 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1327988003645 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1327988003646 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1327988003647 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1327988003648 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1327988003649 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1327988003650 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1327988003651 Rhomboid family; Region: Rhomboid; pfam01694 1327988003652 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1327988003653 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1327988003654 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1327988003655 nucleotide binding site [chemical binding]; other site 1327988003656 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1327988003657 catalytic triad [active] 1327988003658 active site nucleophile [active] 1327988003659 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1327988003660 active site residue [active] 1327988003661 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 1327988003662 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1327988003663 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1327988003664 active site 1327988003665 catalytic site [active] 1327988003666 metal binding site [ion binding]; metal-binding site 1327988003667 dimer interface [polypeptide binding]; other site 1327988003668 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1327988003669 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1327988003670 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1327988003671 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1327988003672 DNA binding residues [nucleotide binding] 1327988003673 putative dimer interface [polypeptide binding]; other site 1327988003674 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1327988003675 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1327988003676 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1327988003677 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1327988003678 dUTPase; Region: dUTPase_2; pfam08761 1327988003679 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1327988003680 active site 1327988003681 homodimer interface [polypeptide binding]; other site 1327988003682 metal binding site [ion binding]; metal-binding site 1327988003683 HTH-like domain; Region: HTH_21; pfam13276 1327988003684 Integrase core domain; Region: rve; pfam00665 1327988003685 Integrase core domain; Region: rve_3; pfam13683 1327988003686 Helix-turn-helix domain; Region: HTH_28; pfam13518 1327988003687 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988003688 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1327988003689 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1327988003690 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1327988003691 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1327988003692 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1327988003693 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1327988003694 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1327988003695 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1327988003696 active site 1327988003697 elongation factor P; Validated; Region: PRK00529 1327988003698 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1327988003699 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1327988003700 RNA binding site [nucleotide binding]; other site 1327988003701 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1327988003702 RNA binding site [nucleotide binding]; other site 1327988003703 Asp23 family; Region: Asp23; pfam03780 1327988003704 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1327988003705 putative RNA binding site [nucleotide binding]; other site 1327988003706 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1327988003707 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1327988003708 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1327988003709 homodimer interface [polypeptide binding]; other site 1327988003710 NADP binding site [chemical binding]; other site 1327988003711 substrate binding site [chemical binding]; other site 1327988003712 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1327988003713 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1327988003714 generic binding surface II; other site 1327988003715 generic binding surface I; other site 1327988003716 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1327988003717 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1327988003718 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1327988003719 substrate binding pocket [chemical binding]; other site 1327988003720 chain length determination region; other site 1327988003721 substrate-Mg2+ binding site; other site 1327988003722 catalytic residues [active] 1327988003723 aspartate-rich region 1; other site 1327988003724 active site lid residues [active] 1327988003725 aspartate-rich region 2; other site 1327988003726 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1327988003727 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1327988003728 RNA binding surface [nucleotide binding]; other site 1327988003729 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1327988003730 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1327988003731 arginine repressor; Provisional; Region: PRK04280 1327988003732 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1327988003733 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1327988003734 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1327988003735 Walker A/P-loop; other site 1327988003736 ATP binding site [chemical binding]; other site 1327988003737 Q-loop/lid; other site 1327988003738 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1327988003739 ABC transporter signature motif; other site 1327988003740 Walker B; other site 1327988003741 D-loop; other site 1327988003742 H-loop/switch region; other site 1327988003743 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1327988003744 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1327988003745 Walker A/P-loop; other site 1327988003746 ATP binding site [chemical binding]; other site 1327988003747 Q-loop/lid; other site 1327988003748 ABC transporter signature motif; other site 1327988003749 Walker B; other site 1327988003750 D-loop; other site 1327988003751 H-loop/switch region; other site 1327988003752 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1327988003753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988003754 dimer interface [polypeptide binding]; other site 1327988003755 conserved gate region; other site 1327988003756 putative PBP binding loops; other site 1327988003757 ABC-ATPase subunit interface; other site 1327988003758 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1327988003759 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1327988003760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988003761 dimer interface [polypeptide binding]; other site 1327988003762 conserved gate region; other site 1327988003763 putative PBP binding loops; other site 1327988003764 ABC-ATPase subunit interface; other site 1327988003765 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1327988003766 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1327988003767 catalytic site [active] 1327988003768 G-X2-G-X-G-K; other site 1327988003769 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1327988003770 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1327988003771 Flavoprotein; Region: Flavoprotein; pfam02441 1327988003772 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1327988003773 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1327988003774 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1327988003775 ATP binding site [chemical binding]; other site 1327988003776 putative Mg++ binding site [ion binding]; other site 1327988003777 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1327988003778 nucleotide binding region [chemical binding]; other site 1327988003779 ATP-binding site [chemical binding]; other site 1327988003780 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1327988003781 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1327988003782 putative active site [active] 1327988003783 substrate binding site [chemical binding]; other site 1327988003784 putative cosubstrate binding site; other site 1327988003785 catalytic site [active] 1327988003786 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1327988003787 substrate binding site [chemical binding]; other site 1327988003788 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1327988003789 NusB family; Region: NusB; pfam01029 1327988003790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1327988003791 S-adenosylmethionine binding site [chemical binding]; other site 1327988003792 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1327988003793 active site 1327988003794 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1327988003795 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1327988003796 active site 1327988003797 ATP binding site [chemical binding]; other site 1327988003798 substrate binding site [chemical binding]; other site 1327988003799 activation loop (A-loop); other site 1327988003800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1327988003801 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1327988003802 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1327988003803 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1327988003804 GTPase RsgA; Reviewed; Region: PRK00098 1327988003805 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1327988003806 RNA binding site [nucleotide binding]; other site 1327988003807 homodimer interface [polypeptide binding]; other site 1327988003808 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1327988003809 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1327988003810 GTP/Mg2+ binding site [chemical binding]; other site 1327988003811 G4 box; other site 1327988003812 G5 box; other site 1327988003813 G1 box; other site 1327988003814 Switch I region; other site 1327988003815 G2 box; other site 1327988003816 G3 box; other site 1327988003817 Switch II region; other site 1327988003818 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1327988003819 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1327988003820 substrate binding site [chemical binding]; other site 1327988003821 hexamer interface [polypeptide binding]; other site 1327988003822 metal binding site [ion binding]; metal-binding site 1327988003823 Thiamine pyrophosphokinase; Region: TPK; cd07995 1327988003824 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1327988003825 active site 1327988003826 dimerization interface [polypeptide binding]; other site 1327988003827 thiamine binding site [chemical binding]; other site 1327988003828 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1327988003829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1327988003830 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1327988003831 DAK2 domain; Region: Dak2; pfam02734 1327988003832 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1327988003833 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1327988003834 generic binding surface II; other site 1327988003835 ssDNA binding site; other site 1327988003836 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1327988003837 ATP binding site [chemical binding]; other site 1327988003838 putative Mg++ binding site [ion binding]; other site 1327988003839 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1327988003840 nucleotide binding region [chemical binding]; other site 1327988003841 ATP-binding site [chemical binding]; other site 1327988003842 putative phosphate acyltransferase; Provisional; Region: PRK05331 1327988003843 acyl carrier protein; Provisional; Region: acpP; PRK00982 1327988003844 ribonuclease III; Reviewed; Region: rnc; PRK00102 1327988003845 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1327988003846 dimerization interface [polypeptide binding]; other site 1327988003847 active site 1327988003848 metal binding site [ion binding]; metal-binding site 1327988003849 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1327988003850 dsRNA binding site [nucleotide binding]; other site 1327988003851 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1327988003852 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1327988003853 Walker A/P-loop; other site 1327988003854 ATP binding site [chemical binding]; other site 1327988003855 Q-loop/lid; other site 1327988003856 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1327988003857 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1327988003858 ABC transporter signature motif; other site 1327988003859 Walker B; other site 1327988003860 D-loop; other site 1327988003861 H-loop/switch region; other site 1327988003862 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1327988003863 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1327988003864 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1327988003865 P loop; other site 1327988003866 GTP binding site [chemical binding]; other site 1327988003867 putative DNA-binding protein; Validated; Region: PRK00118 1327988003868 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1327988003869 signal recognition particle protein; Provisional; Region: PRK10867 1327988003870 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1327988003871 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1327988003872 P loop; other site 1327988003873 GTP binding site [chemical binding]; other site 1327988003874 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1327988003875 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1327988003876 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1327988003877 KH domain; Region: KH_4; pfam13083 1327988003878 G-X-X-G motif; other site 1327988003879 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1327988003880 RimM N-terminal domain; Region: RimM; pfam01782 1327988003881 PRC-barrel domain; Region: PRC; pfam05239 1327988003882 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1327988003883 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1327988003884 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1327988003885 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1327988003886 MucBP domain; Region: MucBP; pfam06458 1327988003887 MucBP domain; Region: MucBP; pfam06458 1327988003888 MucBP domain; Region: MucBP; pfam06458 1327988003889 MucBP domain; Region: MucBP; pfam06458 1327988003890 MucBP domain; Region: MucBP; pfam06458 1327988003891 MucBP domain; Region: MucBP; pfam06458 1327988003892 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 1327988003893 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1327988003894 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1327988003895 Walker A/P-loop; other site 1327988003896 ATP binding site [chemical binding]; other site 1327988003897 Q-loop/lid; other site 1327988003898 ABC transporter signature motif; other site 1327988003899 Walker B; other site 1327988003900 D-loop; other site 1327988003901 H-loop/switch region; other site 1327988003902 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1327988003903 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1327988003904 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1327988003905 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1327988003906 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1327988003907 glutamine binding [chemical binding]; other site 1327988003908 catalytic triad [active] 1327988003909 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1327988003910 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1327988003911 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1327988003912 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1327988003913 active site 1327988003914 ribulose/triose binding site [chemical binding]; other site 1327988003915 phosphate binding site [ion binding]; other site 1327988003916 substrate (anthranilate) binding pocket [chemical binding]; other site 1327988003917 product (indole) binding pocket [chemical binding]; other site 1327988003918 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1327988003919 active site 1327988003920 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1327988003921 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1327988003922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988003923 catalytic residue [active] 1327988003924 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1327988003925 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1327988003926 substrate binding site [chemical binding]; other site 1327988003927 active site 1327988003928 catalytic residues [active] 1327988003929 heterodimer interface [polypeptide binding]; other site 1327988003930 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1327988003931 Isochorismatase family; Region: Isochorismatase; pfam00857 1327988003932 catalytic triad [active] 1327988003933 conserved cis-peptide bond; other site 1327988003934 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1327988003935 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1327988003936 NADP binding site [chemical binding]; other site 1327988003937 dimer interface [polypeptide binding]; other site 1327988003938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1327988003939 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1327988003940 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1327988003941 metal binding site [ion binding]; metal-binding site 1327988003942 dimer interface [polypeptide binding]; other site 1327988003943 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1327988003944 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1327988003945 catalytic Zn binding site [ion binding]; other site 1327988003946 NAD(P) binding site [chemical binding]; other site 1327988003947 structural Zn binding site [ion binding]; other site 1327988003948 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1327988003949 short chain dehydrogenase; Validated; Region: PRK06182 1327988003950 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1327988003951 NADP binding site [chemical binding]; other site 1327988003952 active site 1327988003953 steroid binding site; other site 1327988003954 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1327988003955 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1327988003956 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1327988003957 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1327988003958 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1327988003959 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1327988003960 dimer interface [polypeptide binding]; other site 1327988003961 active site 1327988003962 CoA binding pocket [chemical binding]; other site 1327988003963 acyl carrier protein; Provisional; Region: acpP; PRK00982 1327988003964 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1327988003965 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1327988003966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1327988003967 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1327988003968 NAD(P) binding site [chemical binding]; other site 1327988003969 active site 1327988003970 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1327988003971 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1327988003972 dimer interface [polypeptide binding]; other site 1327988003973 active site 1327988003974 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1327988003975 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1327988003976 carboxyltransferase (CT) interaction site; other site 1327988003977 biotinylation site [posttranslational modification]; other site 1327988003978 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1327988003979 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1327988003980 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1327988003981 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1327988003982 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1327988003983 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1327988003984 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1327988003985 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1327988003986 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 1327988003987 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1327988003988 NAD binding site [chemical binding]; other site 1327988003989 homotetramer interface [polypeptide binding]; other site 1327988003990 homodimer interface [polypeptide binding]; other site 1327988003991 substrate binding site [chemical binding]; other site 1327988003992 active site 1327988003993 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1327988003994 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1327988003995 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1327988003996 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988003997 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1327988003998 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1327988003999 dimerization interface [polypeptide binding]; other site 1327988004000 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1327988004001 GTPase RsgA; Reviewed; Region: PRK01889 1327988004002 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1327988004003 RNA binding site [nucleotide binding]; other site 1327988004004 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1327988004005 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1327988004006 GTP/Mg2+ binding site [chemical binding]; other site 1327988004007 G4 box; other site 1327988004008 G5 box; other site 1327988004009 G1 box; other site 1327988004010 Switch I region; other site 1327988004011 G2 box; other site 1327988004012 G3 box; other site 1327988004013 Switch II region; other site 1327988004014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988004015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988004016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988004017 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988004018 putative substrate translocation pore; other site 1327988004019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988004020 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1327988004021 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1327988004022 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1327988004023 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1327988004024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1327988004025 S-adenosylmethionine binding site [chemical binding]; other site 1327988004026 putative transposase OrfB; Reviewed; Region: PHA02517 1327988004027 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1327988004028 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1327988004029 TspO/MBR family; Region: TspO_MBR; pfam03073 1327988004030 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1327988004031 Ligand Binding Site [chemical binding]; other site 1327988004032 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1327988004033 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1327988004034 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1327988004035 CsbD-like; Region: CsbD; cl17424 1327988004036 Peptidase family C69; Region: Peptidase_C69; pfam03577 1327988004037 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 1327988004038 active site 1 [active] 1327988004039 dimer interface [polypeptide binding]; other site 1327988004040 hexamer interface [polypeptide binding]; other site 1327988004041 active site 2 [active] 1327988004042 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1327988004043 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1327988004044 active site 1327988004045 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1327988004046 substrate binding site [chemical binding]; other site 1327988004047 catalytic residues [active] 1327988004048 dimer interface [polypeptide binding]; other site 1327988004049 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1327988004050 UbiA prenyltransferase family; Region: UbiA; pfam01040 1327988004051 Ion channel; Region: Ion_trans_2; pfam07885 1327988004052 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 1327988004053 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1327988004054 inhibitor-cofactor binding pocket; inhibition site 1327988004055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988004056 catalytic residue [active] 1327988004057 amino acid transporter; Region: 2A0306; TIGR00909 1327988004058 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1327988004059 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1327988004060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988004061 active site 1327988004062 motif I; other site 1327988004063 motif II; other site 1327988004064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1327988004065 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1327988004066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1327988004067 S-adenosylmethionine binding site [chemical binding]; other site 1327988004068 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1327988004069 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1327988004070 Double zinc ribbon; Region: DZR; pfam12773 1327988004071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988004072 putative substrate translocation pore; other site 1327988004073 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988004074 maltose phosphorylase; Provisional; Region: PRK13807 1327988004075 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1327988004076 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1327988004077 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1327988004078 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1327988004079 active site 1327988004080 catalytic residues [active] 1327988004081 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1327988004082 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1327988004083 homotetramer interface [polypeptide binding]; other site 1327988004084 FMN binding site [chemical binding]; other site 1327988004085 homodimer contacts [polypeptide binding]; other site 1327988004086 putative active site [active] 1327988004087 putative substrate binding site [chemical binding]; other site 1327988004088 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1327988004089 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1327988004090 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1327988004091 diphosphomevalonate decarboxylase; Region: PLN02407 1327988004092 mevalonate kinase; Region: mevalon_kin; TIGR00549 1327988004093 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1327988004094 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1327988004095 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1327988004096 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1327988004097 active site 1327988004098 catalytic site [active] 1327988004099 substrate binding site [chemical binding]; other site 1327988004100 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1327988004101 ATP binding site [chemical binding]; other site 1327988004102 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1327988004103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1327988004104 aspartate aminotransferase; Provisional; Region: PRK05764 1327988004105 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1327988004106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988004107 homodimer interface [polypeptide binding]; other site 1327988004108 catalytic residue [active] 1327988004109 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1327988004110 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1327988004111 Dimer interface [polypeptide binding]; other site 1327988004112 anticodon binding site; other site 1327988004113 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1327988004114 homodimer interface [polypeptide binding]; other site 1327988004115 motif 1; other site 1327988004116 motif 2; other site 1327988004117 active site 1327988004118 motif 3; other site 1327988004119 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1327988004120 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1327988004121 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1327988004122 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1327988004123 Walker A/P-loop; other site 1327988004124 ATP binding site [chemical binding]; other site 1327988004125 Q-loop/lid; other site 1327988004126 ABC transporter signature motif; other site 1327988004127 Walker B; other site 1327988004128 D-loop; other site 1327988004129 H-loop/switch region; other site 1327988004130 NIL domain; Region: NIL; pfam09383 1327988004131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988004132 dimer interface [polypeptide binding]; other site 1327988004133 conserved gate region; other site 1327988004134 ABC-ATPase subunit interface; other site 1327988004135 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1327988004136 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1327988004137 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1327988004138 Ligand Binding Site [chemical binding]; other site 1327988004139 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1327988004140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988004141 dimer interface [polypeptide binding]; other site 1327988004142 conserved gate region; other site 1327988004143 putative PBP binding loops; other site 1327988004144 ABC-ATPase subunit interface; other site 1327988004145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988004146 dimer interface [polypeptide binding]; other site 1327988004147 conserved gate region; other site 1327988004148 putative PBP binding loops; other site 1327988004149 ABC-ATPase subunit interface; other site 1327988004150 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1327988004151 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1327988004152 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1327988004153 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1327988004154 Walker A/P-loop; other site 1327988004155 ATP binding site [chemical binding]; other site 1327988004156 Q-loop/lid; other site 1327988004157 ABC transporter signature motif; other site 1327988004158 Walker B; other site 1327988004159 D-loop; other site 1327988004160 H-loop/switch region; other site 1327988004161 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1327988004162 Transglycosylase; Region: Transgly; pfam00912 1327988004163 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1327988004164 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1327988004165 hypothetical protein; Provisional; Region: PRK13660 1327988004166 cell division protein GpsB; Provisional; Region: PRK14127 1327988004167 DivIVA domain; Region: DivI1A_domain; TIGR03544 1327988004168 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1327988004169 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1327988004170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1327988004171 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1327988004172 dimerization interface [polypeptide binding]; other site 1327988004173 putative DNA binding site [nucleotide binding]; other site 1327988004174 putative Zn2+ binding site [ion binding]; other site 1327988004175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988004176 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988004177 putative substrate translocation pore; other site 1327988004178 esterase; Provisional; Region: PRK10566 1327988004179 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1327988004180 SnoaL-like domain; Region: SnoaL_2; pfam12680 1327988004181 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1327988004182 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1327988004183 active site 1327988004184 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1327988004185 putative dimer interface [polypeptide binding]; other site 1327988004186 catalytic triad [active] 1327988004187 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1327988004188 active site 1327988004189 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1327988004190 putative dimer interface [polypeptide binding]; other site 1327988004191 catalytic triad [active] 1327988004192 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1327988004193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1327988004194 Walker A/P-loop; other site 1327988004195 ATP binding site [chemical binding]; other site 1327988004196 Q-loop/lid; other site 1327988004197 ABC transporter signature motif; other site 1327988004198 Walker B; other site 1327988004199 D-loop; other site 1327988004200 H-loop/switch region; other site 1327988004201 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1327988004202 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1327988004203 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1327988004204 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1327988004205 RNA/DNA hybrid binding site [nucleotide binding]; other site 1327988004206 active site 1327988004207 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1327988004208 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1327988004209 Potassium binding sites [ion binding]; other site 1327988004210 Cesium cation binding sites [ion binding]; other site 1327988004211 lipoprotein signal peptidase; Provisional; Region: PRK14797 1327988004212 lipoprotein signal peptidase; Provisional; Region: PRK14787 1327988004213 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1327988004214 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1327988004215 RNA binding surface [nucleotide binding]; other site 1327988004216 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1327988004217 active site 1327988004218 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1327988004219 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1327988004220 active site 1327988004221 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1327988004222 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1327988004223 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1327988004224 catalytic site [active] 1327988004225 subunit interface [polypeptide binding]; other site 1327988004226 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1327988004227 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 1327988004228 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1327988004229 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1327988004230 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 1327988004231 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1327988004232 catalytic core [active] 1327988004233 Domain of unknown function (DU1801); Region: DUF1801; cl17490 1327988004234 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 1327988004235 Chloramphenicol acetyltransferase; Region: CAT; smart01059 1327988004236 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 1327988004237 GIY-YIG motif/motif A; other site 1327988004238 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 1327988004239 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1327988004240 nudix motif; other site 1327988004241 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1327988004242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988004243 Walker A/P-loop; other site 1327988004244 ATP binding site [chemical binding]; other site 1327988004245 Q-loop/lid; other site 1327988004246 ABC transporter signature motif; other site 1327988004247 Walker B; other site 1327988004248 D-loop; other site 1327988004249 H-loop/switch region; other site 1327988004250 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1327988004251 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1327988004252 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1327988004253 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1327988004254 MarR family; Region: MarR_2; pfam12802 1327988004255 EDD domain protein, DegV family; Region: DegV; TIGR00762 1327988004256 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1327988004257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1327988004258 Coenzyme A binding pocket [chemical binding]; other site 1327988004259 Protein of unknown function (DUF975); Region: DUF975; cl10504 1327988004260 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1327988004261 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1327988004262 nucleotide binding site/active site [active] 1327988004263 HIT family signature motif; other site 1327988004264 catalytic residue [active] 1327988004265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988004266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988004267 putative substrate translocation pore; other site 1327988004268 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1327988004269 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1327988004270 Predicted membrane protein [Function unknown]; Region: COG2035 1327988004271 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1327988004272 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1327988004273 L-lactate permease; Region: Lactate_perm; cl00701 1327988004274 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1327988004275 substrate binding site; other site 1327988004276 dimer interface; other site 1327988004277 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1327988004278 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1327988004279 putative NAD(P) binding site [chemical binding]; other site 1327988004280 putative catalytic Zn binding site [ion binding]; other site 1327988004281 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1327988004282 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1327988004283 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1327988004284 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1327988004285 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1327988004286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1327988004287 Coenzyme A binding pocket [chemical binding]; other site 1327988004288 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1327988004289 MarR family; Region: MarR; pfam01047 1327988004290 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1327988004291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1327988004292 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1327988004293 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1327988004294 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1327988004295 active site 1327988004296 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1327988004297 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1327988004298 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1327988004299 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1327988004300 SelR domain; Region: SelR; pfam01641 1327988004301 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1327988004302 DHH family; Region: DHH; pfam01368 1327988004303 DHHA2 domain; Region: DHHA2; pfam02833 1327988004304 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988004305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1327988004306 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1327988004307 dimerization interface [polypeptide binding]; other site 1327988004308 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1327988004309 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1327988004310 CAP-like domain; other site 1327988004311 active site 1327988004312 primary dimer interface [polypeptide binding]; other site 1327988004313 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1327988004314 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1327988004315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1327988004316 ATP binding site [chemical binding]; other site 1327988004317 Mg2+ binding site [ion binding]; other site 1327988004318 G-X-G motif; other site 1327988004319 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1327988004320 anchoring element; other site 1327988004321 dimer interface [polypeptide binding]; other site 1327988004322 ATP binding site [chemical binding]; other site 1327988004323 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1327988004324 active site 1327988004325 putative metal-binding site [ion binding]; other site 1327988004326 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1327988004327 membrane protein; Provisional; Region: PRK14392 1327988004328 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1327988004329 active site 1327988004330 catalytic residues [active] 1327988004331 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1327988004332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988004333 Walker A motif; other site 1327988004334 ATP binding site [chemical binding]; other site 1327988004335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988004336 Walker B motif; other site 1327988004337 arginine finger; other site 1327988004338 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1327988004339 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1327988004340 active site 1327988004341 HslU subunit interaction site [polypeptide binding]; other site 1327988004342 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1327988004343 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1327988004344 active site 1327988004345 DNA binding site [nucleotide binding] 1327988004346 Int/Topo IB signature motif; other site 1327988004347 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1327988004348 Glucose inhibited division protein A; Region: GIDA; pfam01134 1327988004349 DNA topoisomerase I; Validated; Region: PRK05582 1327988004350 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1327988004351 active site 1327988004352 interdomain interaction site; other site 1327988004353 putative metal-binding site [ion binding]; other site 1327988004354 nucleotide binding site [chemical binding]; other site 1327988004355 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1327988004356 domain I; other site 1327988004357 DNA binding groove [nucleotide binding] 1327988004358 phosphate binding site [ion binding]; other site 1327988004359 domain II; other site 1327988004360 domain III; other site 1327988004361 nucleotide binding site [chemical binding]; other site 1327988004362 catalytic site [active] 1327988004363 domain IV; other site 1327988004364 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1327988004365 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1327988004366 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1327988004367 DNA protecting protein DprA; Region: dprA; TIGR00732 1327988004368 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1327988004369 RNA/DNA hybrid binding site [nucleotide binding]; other site 1327988004370 active site 1327988004371 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 1327988004372 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1327988004373 GTP/Mg2+ binding site [chemical binding]; other site 1327988004374 G4 box; other site 1327988004375 G5 box; other site 1327988004376 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1327988004377 G1 box; other site 1327988004378 G1 box; other site 1327988004379 GTP/Mg2+ binding site [chemical binding]; other site 1327988004380 Switch I region; other site 1327988004381 G2 box; other site 1327988004382 G2 box; other site 1327988004383 G3 box; other site 1327988004384 G3 box; other site 1327988004385 Switch II region; other site 1327988004386 Switch II region; other site 1327988004387 G4 box; other site 1327988004388 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1327988004389 substrate binding site [chemical binding]; other site 1327988004390 THF binding site; other site 1327988004391 zinc-binding site [ion binding]; other site 1327988004392 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988004393 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1327988004394 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1327988004395 dimerization interface [polypeptide binding]; other site 1327988004396 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1327988004397 Restriction endonuclease; Region: Mrr_cat; pfam04471 1327988004398 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1327988004399 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1327988004400 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1327988004401 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1327988004402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988004403 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988004404 putative substrate translocation pore; other site 1327988004405 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1327988004406 C-terminal peptidase (prc); Region: prc; TIGR00225 1327988004407 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1327988004408 protein binding site [polypeptide binding]; other site 1327988004409 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1327988004410 Catalytic dyad [active] 1327988004411 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1327988004412 hypothetical protein; Provisional; Region: PRK13672 1327988004413 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1327988004414 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1327988004415 active site 1327988004416 catalytic triad [active] 1327988004417 oxyanion hole [active] 1327988004418 EDD domain protein, DegV family; Region: DegV; TIGR00762 1327988004419 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1327988004420 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1327988004421 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1327988004422 folate binding site [chemical binding]; other site 1327988004423 NADP+ binding site [chemical binding]; other site 1327988004424 thymidylate synthase; Region: thym_sym; TIGR03284 1327988004425 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1327988004426 dimerization interface [polypeptide binding]; other site 1327988004427 active site 1327988004428 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1327988004429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988004430 Walker A/P-loop; other site 1327988004431 ATP binding site [chemical binding]; other site 1327988004432 Q-loop/lid; other site 1327988004433 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1327988004434 ABC transporter signature motif; other site 1327988004435 Walker B; other site 1327988004436 D-loop; other site 1327988004437 ABC transporter; Region: ABC_tran_2; pfam12848 1327988004438 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1327988004439 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1327988004440 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1327988004441 active site 1327988004442 NTP binding site [chemical binding]; other site 1327988004443 metal binding triad [ion binding]; metal-binding site 1327988004444 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1327988004445 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1327988004446 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1327988004447 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1327988004448 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1327988004449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1327988004450 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1327988004451 active site 1327988004452 motif I; other site 1327988004453 motif II; other site 1327988004454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988004455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1327988004456 binding surface 1327988004457 TPR motif; other site 1327988004458 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1327988004459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1327988004460 binding surface 1327988004461 TPR motif; other site 1327988004462 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1327988004463 binding surface 1327988004464 TPR motif; other site 1327988004465 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1327988004466 IHF dimer interface [polypeptide binding]; other site 1327988004467 IHF - DNA interface [nucleotide binding]; other site 1327988004468 GTP-binding protein Der; Reviewed; Region: PRK00093 1327988004469 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1327988004470 G1 box; other site 1327988004471 GTP/Mg2+ binding site [chemical binding]; other site 1327988004472 Switch I region; other site 1327988004473 G2 box; other site 1327988004474 Switch II region; other site 1327988004475 G3 box; other site 1327988004476 G4 box; other site 1327988004477 G5 box; other site 1327988004478 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1327988004479 G1 box; other site 1327988004480 GTP/Mg2+ binding site [chemical binding]; other site 1327988004481 Switch I region; other site 1327988004482 G2 box; other site 1327988004483 G3 box; other site 1327988004484 Switch II region; other site 1327988004485 G4 box; other site 1327988004486 G5 box; other site 1327988004487 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1327988004488 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1327988004489 RNA binding site [nucleotide binding]; other site 1327988004490 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1327988004491 RNA binding site [nucleotide binding]; other site 1327988004492 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1327988004493 RNA binding site [nucleotide binding]; other site 1327988004494 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1327988004495 RNA binding site [nucleotide binding]; other site 1327988004496 cytidylate kinase; Provisional; Region: cmk; PRK00023 1327988004497 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1327988004498 CMP-binding site; other site 1327988004499 The sites determining sugar specificity; other site 1327988004500 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1327988004501 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1327988004502 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1327988004503 ATP binding site [chemical binding]; other site 1327988004504 putative Mg++ binding site [ion binding]; other site 1327988004505 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1327988004506 nucleotide binding region [chemical binding]; other site 1327988004507 ATP-binding site [chemical binding]; other site 1327988004508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1327988004509 Predicted membrane protein [Function unknown]; Region: COG3601 1327988004510 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1327988004511 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1327988004512 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1327988004513 RNA binding surface [nucleotide binding]; other site 1327988004514 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1327988004515 active site 1327988004516 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1327988004517 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1327988004518 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1327988004519 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1327988004520 active site 1327988004521 Int/Topo IB signature motif; other site 1327988004522 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1327988004523 S1 domain; Region: S1_2; pfam13509 1327988004524 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1327988004525 pyruvate kinase; Provisional; Region: PRK06354 1327988004526 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1327988004527 domain interfaces; other site 1327988004528 active site 1327988004529 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1327988004530 6-phosphofructokinase; Provisional; Region: PRK03202 1327988004531 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1327988004532 active site 1327988004533 ADP/pyrophosphate binding site [chemical binding]; other site 1327988004534 dimerization interface [polypeptide binding]; other site 1327988004535 allosteric effector site; other site 1327988004536 fructose-1,6-bisphosphate binding site; other site 1327988004537 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1327988004538 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1327988004539 active site 1327988004540 PHP Thumb interface [polypeptide binding]; other site 1327988004541 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1327988004542 generic binding surface I; other site 1327988004543 generic binding surface II; other site 1327988004544 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1327988004545 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1327988004546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988004547 Walker A motif; other site 1327988004548 ATP binding site [chemical binding]; other site 1327988004549 Walker B motif; other site 1327988004550 arginine finger; other site 1327988004551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988004552 Walker A motif; other site 1327988004553 ATP binding site [chemical binding]; other site 1327988004554 Walker B motif; other site 1327988004555 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1327988004556 peptidase T; Region: peptidase-T; TIGR01882 1327988004557 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1327988004558 metal binding site [ion binding]; metal-binding site 1327988004559 dimer interface [polypeptide binding]; other site 1327988004560 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1327988004561 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1327988004562 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1327988004563 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1327988004564 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1327988004565 Family of unknown function (DUF633); Region: DUF633; pfam04816 1327988004566 O-Antigen ligase; Region: Wzy_C; pfam04932 1327988004567 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1327988004568 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1327988004569 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988004570 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1327988004571 Walker A/P-loop; other site 1327988004572 ATP binding site [chemical binding]; other site 1327988004573 Q-loop/lid; other site 1327988004574 ABC transporter signature motif; other site 1327988004575 Walker B; other site 1327988004576 D-loop; other site 1327988004577 H-loop/switch region; other site 1327988004578 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1327988004579 MarR family; Region: MarR_2; pfam12802 1327988004580 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1327988004581 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1327988004582 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1327988004583 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1327988004584 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1327988004585 active site residue [active] 1327988004586 MarR family; Region: MarR_2; cl17246 1327988004587 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1327988004588 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 1327988004589 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1327988004590 putative NAD(P) binding site [chemical binding]; other site 1327988004591 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 1327988004592 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 1327988004593 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1327988004594 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1327988004595 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1327988004596 enolase; Provisional; Region: eno; PRK00077 1327988004597 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1327988004598 dimer interface [polypeptide binding]; other site 1327988004599 metal binding site [ion binding]; metal-binding site 1327988004600 substrate binding pocket [chemical binding]; other site 1327988004601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988004602 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988004603 putative substrate translocation pore; other site 1327988004604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988004605 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1327988004606 MarR family; Region: MarR_2; pfam12802 1327988004607 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1327988004608 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1327988004609 metal binding site [ion binding]; metal-binding site 1327988004610 dimer interface [polypeptide binding]; other site 1327988004611 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1327988004612 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1327988004613 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1327988004614 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1327988004615 active site residue [active] 1327988004616 coenzyme A disulfide reductase; Provisional; Region: PRK13512 1327988004617 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1327988004618 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1327988004619 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1327988004620 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1327988004621 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1327988004622 nudix motif; other site 1327988004623 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1327988004624 ArsC family; Region: ArsC; pfam03960 1327988004625 putative catalytic residues [active] 1327988004626 thiol/disulfide switch; other site 1327988004627 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1327988004628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1327988004629 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1327988004630 NAD(P) binding site [chemical binding]; other site 1327988004631 active site 1327988004632 Uncharacterized conserved protein [Function unknown]; Region: COG4715 1327988004633 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1327988004634 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988004635 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1327988004636 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988004637 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1327988004638 DNA-binding interface [nucleotide binding]; DNA binding site 1327988004639 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1327988004640 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1327988004641 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1327988004642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988004643 motif II; other site 1327988004644 maltose O-acetyltransferase; Provisional; Region: PRK10092 1327988004645 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1327988004646 active site 1327988004647 substrate binding site [chemical binding]; other site 1327988004648 trimer interface [polypeptide binding]; other site 1327988004649 CoA binding site [chemical binding]; other site 1327988004650 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1327988004651 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1327988004652 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1327988004653 putative active site [active] 1327988004654 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1327988004655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1327988004656 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1327988004657 NAD(P) binding site [chemical binding]; other site 1327988004658 active site 1327988004659 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012 1327988004660 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988004661 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1327988004662 putative Zn2+ binding site [ion binding]; other site 1327988004663 putative DNA binding site [nucleotide binding]; other site 1327988004664 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1327988004665 dimerization interface [polypeptide binding]; other site 1327988004666 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1327988004667 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1327988004668 putative NAD(P) binding site [chemical binding]; other site 1327988004669 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1327988004670 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1327988004671 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1327988004672 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1327988004673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1327988004674 active site 1327988004675 phosphorylation site [posttranslational modification] 1327988004676 intermolecular recognition site; other site 1327988004677 dimerization interface [polypeptide binding]; other site 1327988004678 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1327988004679 DNA binding residues [nucleotide binding] 1327988004680 dimerization interface [polypeptide binding]; other site 1327988004681 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1327988004682 Histidine kinase; Region: HisKA_3; pfam07730 1327988004683 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1327988004684 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1327988004685 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1327988004686 Walker A/P-loop; other site 1327988004687 ATP binding site [chemical binding]; other site 1327988004688 Q-loop/lid; other site 1327988004689 ABC transporter signature motif; other site 1327988004690 Walker B; other site 1327988004691 D-loop; other site 1327988004692 H-loop/switch region; other site 1327988004693 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1327988004694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1327988004695 Coenzyme A binding pocket [chemical binding]; other site 1327988004696 MarR family; Region: MarR; pfam01047 1327988004697 Predicted membrane protein [Function unknown]; Region: COG2364 1327988004698 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1327988004699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988004700 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1327988004701 Walker A/P-loop; other site 1327988004702 ATP binding site [chemical binding]; other site 1327988004703 Q-loop/lid; other site 1327988004704 ABC transporter signature motif; other site 1327988004705 Walker B; other site 1327988004706 D-loop; other site 1327988004707 H-loop/switch region; other site 1327988004708 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1327988004709 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1327988004710 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1327988004711 Walker A/P-loop; other site 1327988004712 ATP binding site [chemical binding]; other site 1327988004713 Q-loop/lid; other site 1327988004714 ABC transporter signature motif; other site 1327988004715 Walker B; other site 1327988004716 D-loop; other site 1327988004717 H-loop/switch region; other site 1327988004718 Predicted transcriptional regulators [Transcription]; Region: COG1725 1327988004719 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1327988004720 DNA-binding site [nucleotide binding]; DNA binding site 1327988004721 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1327988004722 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1327988004723 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1327988004724 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1327988004725 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1327988004726 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1327988004727 DNA binding residues [nucleotide binding] 1327988004728 DNA primase; Validated; Region: dnaG; PRK05667 1327988004729 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1327988004730 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1327988004731 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1327988004732 active site 1327988004733 metal binding site [ion binding]; metal-binding site 1327988004734 interdomain interaction site; other site 1327988004735 PE-PPE domain; Region: PE-PPE; pfam08237 1327988004736 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1327988004737 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1327988004738 dimer interface [polypeptide binding]; other site 1327988004739 motif 1; other site 1327988004740 active site 1327988004741 motif 2; other site 1327988004742 motif 3; other site 1327988004743 DNA repair protein RecO; Region: reco; TIGR00613 1327988004744 Recombination protein O N terminal; Region: RecO_N; pfam11967 1327988004745 Recombination protein O C terminal; Region: RecO_C; pfam02565 1327988004746 GTPase Era; Reviewed; Region: era; PRK00089 1327988004747 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1327988004748 G1 box; other site 1327988004749 GTP/Mg2+ binding site [chemical binding]; other site 1327988004750 Switch I region; other site 1327988004751 G2 box; other site 1327988004752 Switch II region; other site 1327988004753 G3 box; other site 1327988004754 G4 box; other site 1327988004755 G5 box; other site 1327988004756 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1327988004757 metal-binding heat shock protein; Provisional; Region: PRK00016 1327988004758 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1327988004759 PhoH-like protein; Region: PhoH; pfam02562 1327988004760 Yqey-like protein; Region: YqeY; pfam09424 1327988004761 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1327988004762 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 1327988004763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1327988004764 NAD(P) binding site [chemical binding]; other site 1327988004765 active site 1327988004766 endonuclease IV; Provisional; Region: PRK01060 1327988004767 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1327988004768 AP (apurinic/apyrimidinic) site pocket; other site 1327988004769 DNA interaction; other site 1327988004770 Metal-binding active site; metal-binding site 1327988004771 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1327988004772 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1327988004773 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1327988004774 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1327988004775 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1327988004776 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1327988004777 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1327988004778 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1327988004779 dimer interface [polypeptide binding]; other site 1327988004780 anticodon binding site; other site 1327988004781 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1327988004782 homodimer interface [polypeptide binding]; other site 1327988004783 motif 1; other site 1327988004784 active site 1327988004785 motif 2; other site 1327988004786 GAD domain; Region: GAD; pfam02938 1327988004787 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1327988004788 active site 1327988004789 motif 3; other site 1327988004790 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1327988004791 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1327988004792 dimer interface [polypeptide binding]; other site 1327988004793 motif 1; other site 1327988004794 active site 1327988004795 motif 2; other site 1327988004796 motif 3; other site 1327988004797 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1327988004798 anticodon binding site; other site 1327988004799 Bacterial SH3 domain; Region: SH3_3; pfam08239 1327988004800 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1327988004801 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1327988004802 active site 1327988004803 metal binding site [ion binding]; metal-binding site 1327988004804 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1327988004805 Phosphotransferase enzyme family; Region: APH; pfam01636 1327988004806 active site 1327988004807 ATP binding site [chemical binding]; other site 1327988004808 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1327988004809 substrate binding site [chemical binding]; other site 1327988004810 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1327988004811 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988004812 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1327988004813 putative active site [active] 1327988004814 dimerization interface [polypeptide binding]; other site 1327988004815 putative tRNAtyr binding site [nucleotide binding]; other site 1327988004816 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1327988004817 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1327988004818 Zn2+ binding site [ion binding]; other site 1327988004819 Mg2+ binding site [ion binding]; other site 1327988004820 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1327988004821 synthetase active site [active] 1327988004822 NTP binding site [chemical binding]; other site 1327988004823 metal binding site [ion binding]; metal-binding site 1327988004824 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1327988004825 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1327988004826 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1327988004827 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 1327988004828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1327988004829 S-adenosylmethionine binding site [chemical binding]; other site 1327988004830 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1327988004831 active site 1327988004832 DNA binding site [nucleotide binding] 1327988004833 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1327988004834 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1327988004835 Int/Topo IB signature motif; other site 1327988004836 GTP-binding protein LepA; Provisional; Region: PRK05433 1327988004837 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1327988004838 G1 box; other site 1327988004839 putative GEF interaction site [polypeptide binding]; other site 1327988004840 GTP/Mg2+ binding site [chemical binding]; other site 1327988004841 Switch I region; other site 1327988004842 G2 box; other site 1327988004843 G3 box; other site 1327988004844 Switch II region; other site 1327988004845 G4 box; other site 1327988004846 G5 box; other site 1327988004847 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1327988004848 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1327988004849 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1327988004850 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1327988004851 DltD N-terminal region; Region: DltD_N; pfam04915 1327988004852 DltD central region; Region: DltD_M; pfam04918 1327988004853 DltD C-terminal region; Region: DltD_C; pfam04914 1327988004854 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1327988004855 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1327988004856 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1327988004857 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1327988004858 acyl-activating enzyme (AAE) consensus motif; other site 1327988004859 AMP binding site [chemical binding]; other site 1327988004860 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1327988004861 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1327988004862 Beta-lactamase; Region: Beta-lactamase; pfam00144 1327988004863 chaperone protein DnaJ; Provisional; Region: PRK14276 1327988004864 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1327988004865 HSP70 interaction site [polypeptide binding]; other site 1327988004866 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1327988004867 substrate binding site [polypeptide binding]; other site 1327988004868 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1327988004869 Zn binding sites [ion binding]; other site 1327988004870 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1327988004871 dimer interface [polypeptide binding]; other site 1327988004872 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1327988004873 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1327988004874 nucleotide binding site [chemical binding]; other site 1327988004875 GrpE; Region: GrpE; pfam01025 1327988004876 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1327988004877 dimer interface [polypeptide binding]; other site 1327988004878 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1327988004879 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1327988004880 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1327988004881 NLE (NUC135) domain; Region: NLE; pfam08154 1327988004882 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1327988004883 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1327988004884 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1327988004885 active site 1327988004886 Riboflavin kinase; Region: Flavokinase; smart00904 1327988004887 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1327988004888 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1327988004889 RNA binding site [nucleotide binding]; other site 1327988004890 active site 1327988004891 shikimate kinase; Reviewed; Region: aroK; PRK00131 1327988004892 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1327988004893 ADP binding site [chemical binding]; other site 1327988004894 magnesium binding site [ion binding]; other site 1327988004895 putative shikimate binding site; other site 1327988004896 prephenate dehydrogenase; Validated; Region: PRK06545 1327988004897 prephenate dehydrogenase; Validated; Region: PRK08507 1327988004898 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1327988004899 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1327988004900 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1327988004901 hinge; other site 1327988004902 active site 1327988004903 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1327988004904 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1327988004905 Tetramer interface [polypeptide binding]; other site 1327988004906 active site 1327988004907 FMN-binding site [chemical binding]; other site 1327988004908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988004909 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988004910 putative substrate translocation pore; other site 1327988004911 Chorismate mutase type II; Region: CM_2; pfam01817 1327988004912 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1327988004913 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1327988004914 translation initiation factor IF-2; Region: IF-2; TIGR00487 1327988004915 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1327988004916 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1327988004917 G1 box; other site 1327988004918 putative GEF interaction site [polypeptide binding]; other site 1327988004919 GTP/Mg2+ binding site [chemical binding]; other site 1327988004920 Switch I region; other site 1327988004921 G2 box; other site 1327988004922 G3 box; other site 1327988004923 Switch II region; other site 1327988004924 G4 box; other site 1327988004925 G5 box; other site 1327988004926 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1327988004927 Translation-initiation factor 2; Region: IF-2; pfam11987 1327988004928 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1327988004929 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1327988004930 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1327988004931 putative RNA binding cleft [nucleotide binding]; other site 1327988004932 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1327988004933 NusA N-terminal domain; Region: NusA_N; pfam08529 1327988004934 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1327988004935 RNA binding site [nucleotide binding]; other site 1327988004936 homodimer interface [polypeptide binding]; other site 1327988004937 NusA-like KH domain; Region: KH_5; pfam13184 1327988004938 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1327988004939 G-X-X-G motif; other site 1327988004940 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1327988004941 Sm and related proteins; Region: Sm_like; cl00259 1327988004942 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1327988004943 putative oligomer interface [polypeptide binding]; other site 1327988004944 putative RNA binding site [nucleotide binding]; other site 1327988004945 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1327988004946 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1327988004947 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1327988004948 generic binding surface II; other site 1327988004949 generic binding surface I; other site 1327988004950 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1327988004951 active site 1327988004952 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1327988004953 active site 1327988004954 catalytic site [active] 1327988004955 substrate binding site [chemical binding]; other site 1327988004956 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1327988004957 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1327988004958 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1327988004959 dimer interface [polypeptide binding]; other site 1327988004960 motif 1; other site 1327988004961 active site 1327988004962 motif 2; other site 1327988004963 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1327988004964 putative deacylase active site [active] 1327988004965 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1327988004966 active site 1327988004967 motif 3; other site 1327988004968 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1327988004969 anticodon binding site; other site 1327988004970 RIP metalloprotease RseP; Region: TIGR00054 1327988004971 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1327988004972 active site 1327988004973 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1327988004974 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1327988004975 putative substrate binding region [chemical binding]; other site 1327988004976 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1327988004977 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1327988004978 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 1327988004979 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1327988004980 catalytic residue [active] 1327988004981 putative FPP diphosphate binding site; other site 1327988004982 putative FPP binding hydrophobic cleft; other site 1327988004983 dimer interface [polypeptide binding]; other site 1327988004984 putative IPP diphosphate binding site; other site 1327988004985 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1327988004986 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1327988004987 hinge region; other site 1327988004988 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1327988004989 putative nucleotide binding site [chemical binding]; other site 1327988004990 uridine monophosphate binding site [chemical binding]; other site 1327988004991 homohexameric interface [polypeptide binding]; other site 1327988004992 elongation factor Ts; Provisional; Region: tsf; PRK09377 1327988004993 UBA/TS-N domain; Region: UBA; pfam00627 1327988004994 Elongation factor TS; Region: EF_TS; pfam00889 1327988004995 Elongation factor TS; Region: EF_TS; pfam00889 1327988004996 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1327988004997 rRNA interaction site [nucleotide binding]; other site 1327988004998 S8 interaction site; other site 1327988004999 putative laminin-1 binding site; other site 1327988005000 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1327988005001 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988005002 motif II; other site 1327988005003 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1327988005004 D-lactate dehydrogenase; Validated; Region: PRK08605 1327988005005 homodimer interface [polypeptide binding]; other site 1327988005006 ligand binding site [chemical binding]; other site 1327988005007 NAD binding site [chemical binding]; other site 1327988005008 catalytic site [active] 1327988005009 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1327988005010 GIY-YIG motif/motif A; other site 1327988005011 putative active site [active] 1327988005012 putative metal binding site [ion binding]; other site 1327988005013 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1327988005014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1327988005015 S-adenosylmethionine binding site [chemical binding]; other site 1327988005016 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1327988005017 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1327988005018 putative acyl-acceptor binding pocket; other site 1327988005019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1327988005020 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1327988005021 LexA repressor; Validated; Region: PRK00215 1327988005022 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1327988005023 putative DNA binding site [nucleotide binding]; other site 1327988005024 putative Zn2+ binding site [ion binding]; other site 1327988005025 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1327988005026 Catalytic site [active] 1327988005027 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1327988005028 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1327988005029 dimer interface [polypeptide binding]; other site 1327988005030 active site 1327988005031 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1327988005032 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1327988005033 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1327988005034 Ligand binding site; other site 1327988005035 Putative Catalytic site; other site 1327988005036 DXD motif; other site 1327988005037 Helix-turn-helix domain; Region: HTH_28; pfam13518 1327988005038 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1327988005039 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1327988005040 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1327988005041 Walker A/P-loop; other site 1327988005042 ATP binding site [chemical binding]; other site 1327988005043 Q-loop/lid; other site 1327988005044 ABC transporter signature motif; other site 1327988005045 Walker B; other site 1327988005046 D-loop; other site 1327988005047 H-loop/switch region; other site 1327988005048 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1327988005049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988005050 dimer interface [polypeptide binding]; other site 1327988005051 conserved gate region; other site 1327988005052 ABC-ATPase subunit interface; other site 1327988005053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1327988005054 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1327988005055 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1327988005056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1327988005057 hypothetical protein; Provisional; Region: PRK00967 1327988005058 H+ Antiporter protein; Region: 2A0121; TIGR00900 1327988005059 Helix-turn-helix domain; Region: HTH_20; pfam12840 1327988005060 dimerization interface [polypeptide binding]; other site 1327988005061 putative DNA binding site [nucleotide binding]; other site 1327988005062 putative Zn2+ binding site [ion binding]; other site 1327988005063 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1327988005064 active site 1327988005065 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1327988005066 DHH family; Region: DHH; pfam01368 1327988005067 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1327988005068 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1327988005069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1327988005070 NAD(P) binding site [chemical binding]; other site 1327988005071 active site 1327988005072 ribonuclease Z; Region: RNase_Z; TIGR02651 1327988005073 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1327988005074 GTP1/OBG; Region: GTP1_OBG; pfam01018 1327988005075 Obg GTPase; Region: Obg; cd01898 1327988005076 G1 box; other site 1327988005077 GTP/Mg2+ binding site [chemical binding]; other site 1327988005078 Switch I region; other site 1327988005079 G2 box; other site 1327988005080 G3 box; other site 1327988005081 Switch II region; other site 1327988005082 G4 box; other site 1327988005083 G5 box; other site 1327988005084 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1327988005085 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1327988005086 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1327988005087 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1327988005088 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1327988005089 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1327988005090 putative substrate binding site [chemical binding]; other site 1327988005091 putative ATP binding site [chemical binding]; other site 1327988005092 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1327988005093 active site 1327988005094 phosphorylation site [posttranslational modification] 1327988005095 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1327988005096 active site 1327988005097 P-loop; other site 1327988005098 phosphorylation site [posttranslational modification] 1327988005099 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1327988005100 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1327988005101 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1327988005102 active site 1327988005103 metal binding site [ion binding]; metal-binding site 1327988005104 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1327988005105 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1327988005106 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1327988005107 EPS cluster 1327988005108 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 1327988005109 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1327988005110 active site 1327988005111 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1327988005112 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1327988005113 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1327988005114 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1327988005115 putative ADP-binding pocket [chemical binding]; other site 1327988005116 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1327988005117 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1327988005118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1327988005119 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1327988005120 NAD(P) binding site [chemical binding]; other site 1327988005121 active site 1327988005122 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1327988005123 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1327988005124 active site 1327988005125 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1327988005126 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1327988005127 Chain length determinant protein; Region: Wzz; cl15801 1327988005128 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1327988005129 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1327988005130 GIY-YIG motif/motif A; other site 1327988005131 active site 1327988005132 catalytic site [active] 1327988005133 putative DNA binding site [nucleotide binding]; other site 1327988005134 metal binding site [ion binding]; metal-binding site 1327988005135 UvrB/uvrC motif; Region: UVR; pfam02151 1327988005136 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1327988005137 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1327988005138 DNA binding site [nucleotide binding] 1327988005139 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1327988005140 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1327988005141 Walker A/P-loop; other site 1327988005142 ATP binding site [chemical binding]; other site 1327988005143 Q-loop/lid; other site 1327988005144 ABC transporter signature motif; other site 1327988005145 Walker B; other site 1327988005146 D-loop; other site 1327988005147 H-loop/switch region; other site 1327988005148 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1327988005149 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1327988005150 substrate binding pocket [chemical binding]; other site 1327988005151 membrane-bound complex binding site; other site 1327988005152 hinge residues; other site 1327988005153 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1327988005154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988005155 dimer interface [polypeptide binding]; other site 1327988005156 conserved gate region; other site 1327988005157 putative PBP binding loops; other site 1327988005158 ABC-ATPase subunit interface; other site 1327988005159 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 1327988005160 putative metal binding site [ion binding]; other site 1327988005161 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1327988005162 G1 box; other site 1327988005163 GTP/Mg2+ binding site [chemical binding]; other site 1327988005164 Switch I region; other site 1327988005165 G2 box; other site 1327988005166 G3 box; other site 1327988005167 Switch II region; other site 1327988005168 G4 box; other site 1327988005169 G5 box; other site 1327988005170 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1327988005171 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1327988005172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988005173 Walker A motif; other site 1327988005174 ATP binding site [chemical binding]; other site 1327988005175 Walker B motif; other site 1327988005176 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1327988005177 trigger factor; Provisional; Region: tig; PRK01490 1327988005178 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1327988005179 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1327988005180 elongation factor Tu; Reviewed; Region: PRK00049 1327988005181 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1327988005182 G1 box; other site 1327988005183 GEF interaction site [polypeptide binding]; other site 1327988005184 GTP/Mg2+ binding site [chemical binding]; other site 1327988005185 Switch I region; other site 1327988005186 G2 box; other site 1327988005187 G3 box; other site 1327988005188 Switch II region; other site 1327988005189 G4 box; other site 1327988005190 G5 box; other site 1327988005191 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1327988005192 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1327988005193 Antibiotic Binding Site [chemical binding]; other site 1327988005194 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1327988005195 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1327988005196 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1327988005197 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1327988005198 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1327988005199 dimer interface [polypeptide binding]; other site 1327988005200 active site 1327988005201 catalytic residue [active] 1327988005202 drug efflux system protein MdtG; Provisional; Region: PRK09874 1327988005203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988005204 putative substrate translocation pore; other site 1327988005205 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1327988005206 16S/18S rRNA binding site [nucleotide binding]; other site 1327988005207 S13e-L30e interaction site [polypeptide binding]; other site 1327988005208 25S rRNA binding site [nucleotide binding]; other site 1327988005209 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1327988005210 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1327988005211 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1327988005212 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1327988005213 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1327988005214 Competence protein; Region: Competence; pfam03772 1327988005215 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1327988005216 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1327988005217 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1327988005218 catalytic motif [active] 1327988005219 Zn binding site [ion binding]; other site 1327988005220 SLBB domain; Region: SLBB; pfam10531 1327988005221 comEA protein; Region: comE; TIGR01259 1327988005222 Helix-hairpin-helix motif; Region: HHH; pfam00633 1327988005223 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1327988005224 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1327988005225 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1327988005226 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1327988005227 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1327988005228 active site 1327988005229 (T/H)XGH motif; other site 1327988005230 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1327988005231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1327988005232 S-adenosylmethionine binding site [chemical binding]; other site 1327988005233 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 1327988005234 pyruvate carboxylase; Reviewed; Region: PRK12999 1327988005235 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1327988005236 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1327988005237 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1327988005238 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1327988005239 active site 1327988005240 catalytic residues [active] 1327988005241 metal binding site [ion binding]; metal-binding site 1327988005242 homodimer binding site [polypeptide binding]; other site 1327988005243 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1327988005244 carboxyltransferase (CT) interaction site; other site 1327988005245 biotinylation site [posttranslational modification]; other site 1327988005246 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1327988005247 conserved hypothetical integral membrane protein; Region: TIGR03766 1327988005248 conserved hypothetical integral membrane protein; Region: TIGR03766 1327988005249 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 1327988005250 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1327988005251 DXD motif; other site 1327988005252 exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110 1327988005253 Firmicu-CTERM domain; Region: Firmicu_CTERM; TIGR04145 1327988005254 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1327988005255 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1327988005256 G1 box; other site 1327988005257 putative GEF interaction site [polypeptide binding]; other site 1327988005258 GTP/Mg2+ binding site [chemical binding]; other site 1327988005259 Switch I region; other site 1327988005260 G2 box; other site 1327988005261 G3 box; other site 1327988005262 Switch II region; other site 1327988005263 G4 box; other site 1327988005264 G5 box; other site 1327988005265 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1327988005266 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1327988005267 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1327988005268 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1327988005269 active site 1327988005270 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1327988005271 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1327988005272 substrate binding site [chemical binding]; other site 1327988005273 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1327988005274 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1327988005275 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1327988005276 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1327988005277 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1327988005278 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1327988005279 E3 interaction surface; other site 1327988005280 lipoyl attachment site [posttranslational modification]; other site 1327988005281 e3 binding domain; Region: E3_binding; pfam02817 1327988005282 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1327988005283 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1327988005284 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1327988005285 alpha subunit interface [polypeptide binding]; other site 1327988005286 TPP binding site [chemical binding]; other site 1327988005287 heterodimer interface [polypeptide binding]; other site 1327988005288 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1327988005289 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1327988005290 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1327988005291 TPP-binding site [chemical binding]; other site 1327988005292 heterodimer interface [polypeptide binding]; other site 1327988005293 tetramer interface [polypeptide binding]; other site 1327988005294 phosphorylation loop region [posttranslational modification] 1327988005295 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1327988005296 active site 1327988005297 catalytic residues [active] 1327988005298 metal binding site [ion binding]; metal-binding site 1327988005299 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 1327988005300 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1327988005301 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1327988005302 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1327988005303 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1327988005304 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1327988005305 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1327988005306 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1327988005307 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 1327988005308 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1327988005309 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1327988005310 active site 1327988005311 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1327988005312 AAA domain; Region: AAA_30; pfam13604 1327988005313 Family description; Region: UvrD_C_2; pfam13538 1327988005314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1327988005315 binding surface 1327988005316 TPR motif; other site 1327988005317 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1327988005318 catalytic core [active] 1327988005319 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1327988005320 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1327988005321 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1327988005322 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1327988005323 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1327988005324 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1327988005325 TrkA-N domain; Region: TrkA_N; pfam02254 1327988005326 TrkA-C domain; Region: TrkA_C; pfam02080 1327988005327 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1327988005328 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1327988005329 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1327988005330 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1327988005331 Putative amino acid metabolism; Region: DUF1831; pfam08866 1327988005332 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1327988005333 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1327988005334 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1327988005335 catalytic residue [active] 1327988005336 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1327988005337 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1327988005338 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1327988005339 dimer interface [polypeptide binding]; other site 1327988005340 ADP-ribose binding site [chemical binding]; other site 1327988005341 active site 1327988005342 nudix motif; other site 1327988005343 metal binding site [ion binding]; metal-binding site 1327988005344 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1327988005345 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1327988005346 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1327988005347 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1327988005348 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1327988005349 active site 1327988005350 HIGH motif; other site 1327988005351 nucleotide binding site [chemical binding]; other site 1327988005352 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1327988005353 active site 1327988005354 KMSKS motif; other site 1327988005355 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1327988005356 tRNA binding surface [nucleotide binding]; other site 1327988005357 anticodon binding site; other site 1327988005358 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1327988005359 DivIVA protein; Region: DivIVA; pfam05103 1327988005360 DivIVA domain; Region: DivI1A_domain; TIGR03544 1327988005361 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1327988005362 YGGT family; Region: YGGT; pfam02325 1327988005363 Protein of unknown function (DUF552); Region: DUF552; cl00775 1327988005364 cell division protein FtsZ; Validated; Region: PRK09330 1327988005365 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1327988005366 nucleotide binding site [chemical binding]; other site 1327988005367 SulA interaction site; other site 1327988005368 cell division protein FtsA; Region: ftsA; TIGR01174 1327988005369 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1327988005370 nucleotide binding site [chemical binding]; other site 1327988005371 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 1327988005372 Cell division protein FtsA; Region: FtsA; pfam14450 1327988005373 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 1327988005374 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1327988005375 Cell division protein FtsQ; Region: FtsQ; pfam03799 1327988005376 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1327988005377 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1327988005378 active site 1327988005379 homodimer interface [polypeptide binding]; other site 1327988005380 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1327988005381 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1327988005382 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1327988005383 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1327988005384 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1327988005385 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1327988005386 Mg++ binding site [ion binding]; other site 1327988005387 putative catalytic motif [active] 1327988005388 putative substrate binding site [chemical binding]; other site 1327988005389 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1327988005390 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1327988005391 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1327988005392 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1327988005393 cell division protein FtsL; Region: ftsL_broad; TIGR02209 1327988005394 MraW methylase family; Region: Methyltransf_5; pfam01795 1327988005395 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1327988005396 cell division protein MraZ; Reviewed; Region: PRK00326 1327988005397 MraZ protein; Region: MraZ; pfam02381 1327988005398 MraZ protein; Region: MraZ; pfam02381 1327988005399 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 1327988005400 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1327988005401 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1327988005402 Cl binding site [ion binding]; other site 1327988005403 oligomer interface [polypeptide binding]; other site 1327988005404 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1327988005405 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1327988005406 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1327988005407 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1327988005408 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1327988005409 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1327988005410 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1327988005411 NAD binding site [chemical binding]; other site 1327988005412 substrate binding site [chemical binding]; other site 1327988005413 putative active site [active] 1327988005414 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1327988005415 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1327988005416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1327988005417 S-adenosylmethionine binding site [chemical binding]; other site 1327988005418 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1327988005419 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1327988005420 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1327988005421 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 1327988005422 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1327988005423 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 1327988005424 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1327988005425 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1327988005426 active site 1327988005427 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1327988005428 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1327988005429 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1327988005430 synthetase active site [active] 1327988005431 NTP binding site [chemical binding]; other site 1327988005432 metal binding site [ion binding]; metal-binding site 1327988005433 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1327988005434 catalytic residues [active] 1327988005435 oligoendopeptidase F; Region: pepF; TIGR00181 1327988005436 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1327988005437 active site 1327988005438 Zn binding site [ion binding]; other site 1327988005439 Competence protein CoiA-like family; Region: CoiA; cl11541 1327988005440 adaptor protein; Provisional; Region: PRK02315 1327988005441 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1327988005442 ArsC family; Region: ArsC; pfam03960 1327988005443 putative catalytic residues [active] 1327988005444 thiol/disulfide switch; other site 1327988005445 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1327988005446 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1327988005447 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 1327988005448 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1327988005449 RNA binding site [nucleotide binding]; other site 1327988005450 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1327988005451 active site 1327988005452 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1327988005453 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1327988005454 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 1327988005455 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1327988005456 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988005457 active site 1327988005458 motif I; other site 1327988005459 motif II; other site 1327988005460 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988005461 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1327988005462 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1327988005463 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1327988005464 active site 1327988005465 metal binding site [ion binding]; metal-binding site 1327988005466 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1327988005467 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 1327988005468 putative active site [active] 1327988005469 putative metal binding site [ion binding]; other site 1327988005470 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1327988005471 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1327988005472 propionate/acetate kinase; Provisional; Region: PRK12379 1327988005473 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1327988005474 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1327988005475 S-adenosylmethionine binding site [chemical binding]; other site 1327988005476 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1327988005477 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1327988005478 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1327988005479 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1327988005480 Type II/IV secretion system protein; Region: T2SE; pfam00437 1327988005481 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1327988005482 Walker A motif; other site 1327988005483 ATP binding site [chemical binding]; other site 1327988005484 Walker B motif; other site 1327988005485 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1327988005486 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1327988005487 substrate binding site [chemical binding]; other site 1327988005488 dimer interface [polypeptide binding]; other site 1327988005489 ATP binding site [chemical binding]; other site 1327988005490 hypothetical protein; Validated; Region: PRK00110 1327988005491 DsrE/DsrF-like family; Region: DrsE; cl00672 1327988005492 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1327988005493 catabolite control protein A; Region: ccpA; TIGR01481 1327988005494 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1327988005495 DNA binding site [nucleotide binding] 1327988005496 domain linker motif; other site 1327988005497 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1327988005498 dimerization interface [polypeptide binding]; other site 1327988005499 effector binding site; other site 1327988005500 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1327988005501 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1327988005502 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1327988005503 active site 1327988005504 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1327988005505 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1327988005506 DNA binding residues [nucleotide binding] 1327988005507 putative dimer interface [polypeptide binding]; other site 1327988005508 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1327988005509 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1327988005510 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1327988005511 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1327988005512 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1327988005513 metal binding site [ion binding]; metal-binding site 1327988005514 putative dimer interface [polypeptide binding]; other site 1327988005515 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1327988005516 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1327988005517 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1327988005518 active site 1327988005519 trimer interface [polypeptide binding]; other site 1327988005520 substrate binding site [chemical binding]; other site 1327988005521 CoA binding site [chemical binding]; other site 1327988005522 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1327988005523 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1327988005524 active site 1327988005525 metal binding site [ion binding]; metal-binding site 1327988005526 homotetramer interface [polypeptide binding]; other site 1327988005527 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1327988005528 active site 1327988005529 dimerization interface [polypeptide binding]; other site 1327988005530 glutamate racemase; Provisional; Region: PRK00865 1327988005531 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1327988005532 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1327988005533 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1327988005534 catalytic residues [active] 1327988005535 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1327988005536 MutS domain III; Region: MutS_III; pfam05192 1327988005537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988005538 Walker A/P-loop; other site 1327988005539 ATP binding site [chemical binding]; other site 1327988005540 Q-loop/lid; other site 1327988005541 ABC transporter signature motif; other site 1327988005542 Walker B; other site 1327988005543 D-loop; other site 1327988005544 H-loop/switch region; other site 1327988005545 Smr domain; Region: Smr; pfam01713 1327988005546 Cell division protein ZapA; Region: ZapA; cl01146 1327988005547 hypothetical protein; Provisional; Region: PRK13678 1327988005548 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1327988005549 hypothetical protein; Provisional; Region: PRK05473 1327988005550 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1327988005551 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1327988005552 motif 1; other site 1327988005553 active site 1327988005554 motif 2; other site 1327988005555 motif 3; other site 1327988005556 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1327988005557 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1327988005558 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1327988005559 ATP binding site [chemical binding]; other site 1327988005560 Mg++ binding site [ion binding]; other site 1327988005561 motif III; other site 1327988005562 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1327988005563 nucleotide binding region [chemical binding]; other site 1327988005564 ATP-binding site [chemical binding]; other site 1327988005565 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1327988005566 DHH family; Region: DHH; pfam01368 1327988005567 DHHA1 domain; Region: DHHA1; pfam02272 1327988005568 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1327988005569 active site 1327988005570 DNA polymerase IV; Validated; Region: PRK02406 1327988005571 DNA binding site [nucleotide binding] 1327988005572 Preprotein translocase subunit; Region: YajC; pfam02699 1327988005573 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1327988005574 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1327988005575 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1327988005576 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1327988005577 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1327988005578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988005579 Walker A motif; other site 1327988005580 ATP binding site [chemical binding]; other site 1327988005581 Walker B motif; other site 1327988005582 arginine finger; other site 1327988005583 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1327988005584 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1327988005585 RuvA N terminal domain; Region: RuvA_N; pfam01330 1327988005586 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 1327988005587 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1327988005588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1327988005589 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1327988005590 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1327988005591 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 1327988005592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1327988005593 ATP binding site [chemical binding]; other site 1327988005594 Mg2+ binding site [ion binding]; other site 1327988005595 G-X-G motif; other site 1327988005596 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1327988005597 ATP binding site [chemical binding]; other site 1327988005598 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1327988005599 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1327988005600 MutS domain I; Region: MutS_I; pfam01624 1327988005601 MutS domain II; Region: MutS_II; pfam05188 1327988005602 MutS domain III; Region: MutS_III; pfam05192 1327988005603 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1327988005604 Walker A/P-loop; other site 1327988005605 ATP binding site [chemical binding]; other site 1327988005606 Q-loop/lid; other site 1327988005607 ABC transporter signature motif; other site 1327988005608 Walker B; other site 1327988005609 D-loop; other site 1327988005610 H-loop/switch region; other site 1327988005611 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1327988005612 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1327988005613 putative active site [active] 1327988005614 metal binding site [ion binding]; metal-binding site 1327988005615 homodimer binding site [polypeptide binding]; other site 1327988005616 ribonuclease Y; Region: RNase_Y; TIGR03319 1327988005617 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1327988005618 Zn2+ binding site [ion binding]; other site 1327988005619 Mg2+ binding site [ion binding]; other site 1327988005620 recombinase A; Provisional; Region: recA; PRK09354 1327988005621 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1327988005622 hexamer interface [polypeptide binding]; other site 1327988005623 Walker A motif; other site 1327988005624 ATP binding site [chemical binding]; other site 1327988005625 Walker B motif; other site 1327988005626 competence damage-inducible protein A; Provisional; Region: PRK00549 1327988005627 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1327988005628 putative MPT binding site; other site 1327988005629 Competence-damaged protein; Region: CinA; pfam02464 1327988005630 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1327988005631 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1327988005632 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988005633 non-specific DNA binding site [nucleotide binding]; other site 1327988005634 salt bridge; other site 1327988005635 sequence-specific DNA binding site [nucleotide binding]; other site 1327988005636 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1327988005637 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1327988005638 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1327988005639 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1327988005640 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1327988005641 aspartate kinase; Reviewed; Region: PRK09034 1327988005642 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1327988005643 putative catalytic residues [active] 1327988005644 putative nucleotide binding site [chemical binding]; other site 1327988005645 putative aspartate binding site [chemical binding]; other site 1327988005646 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1327988005647 allosteric regulatory residue; other site 1327988005648 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1327988005649 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1327988005650 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1327988005651 substrate binding pocket [chemical binding]; other site 1327988005652 membrane-bound complex binding site; other site 1327988005653 hinge residues; other site 1327988005654 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1327988005655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988005656 Walker A/P-loop; other site 1327988005657 ATP binding site [chemical binding]; other site 1327988005658 Q-loop/lid; other site 1327988005659 ABC transporter signature motif; other site 1327988005660 Walker B; other site 1327988005661 D-loop; other site 1327988005662 H-loop/switch region; other site 1327988005663 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1327988005664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988005665 dimer interface [polypeptide binding]; other site 1327988005666 conserved gate region; other site 1327988005667 putative PBP binding loops; other site 1327988005668 ABC-ATPase subunit interface; other site 1327988005669 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1327988005670 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1327988005671 Switch I; other site 1327988005672 Switch II; other site 1327988005673 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1327988005674 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1327988005675 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1327988005676 rod shape-determining protein MreC; Provisional; Region: PRK13922 1327988005677 rod shape-determining protein MreC; Region: MreC; pfam04085 1327988005678 rod shape-determining protein MreB; Provisional; Region: PRK13927 1327988005679 MreB and similar proteins; Region: MreB_like; cd10225 1327988005680 nucleotide binding site [chemical binding]; other site 1327988005681 Mg binding site [ion binding]; other site 1327988005682 putative protofilament interaction site [polypeptide binding]; other site 1327988005683 RodZ interaction site [polypeptide binding]; other site 1327988005684 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1327988005685 MPN+ (JAMM) motif; other site 1327988005686 Zinc-binding site [ion binding]; other site 1327988005687 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1327988005688 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1327988005689 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1327988005690 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1327988005691 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1327988005692 active site 1327988005693 HIGH motif; other site 1327988005694 nucleotide binding site [chemical binding]; other site 1327988005695 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1327988005696 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1327988005697 active site 1327988005698 KMSKS motif; other site 1327988005699 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1327988005700 tRNA binding surface [nucleotide binding]; other site 1327988005701 anticodon binding site; other site 1327988005702 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1327988005703 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1327988005704 dimer interface [polypeptide binding]; other site 1327988005705 catalytic triad [active] 1327988005706 peroxidatic and resolving cysteines [active] 1327988005707 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1327988005708 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1327988005709 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1327988005710 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1327988005711 Ligand Binding Site [chemical binding]; other site 1327988005712 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1327988005713 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1327988005714 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1327988005715 catalytic residue [active] 1327988005716 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1327988005717 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1327988005718 GAF domain; Region: GAF_2; pfam13185 1327988005719 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1327988005720 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1327988005721 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1327988005722 RNA binding surface [nucleotide binding]; other site 1327988005723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1327988005724 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1327988005725 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1327988005726 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1327988005727 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1327988005728 dimerization interface [polypeptide binding]; other site 1327988005729 putative DNA binding site [nucleotide binding]; other site 1327988005730 putative Zn2+ binding site [ion binding]; other site 1327988005731 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 1327988005732 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1327988005733 recombination factor protein RarA; Reviewed; Region: PRK13342 1327988005734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988005735 Walker A motif; other site 1327988005736 ATP binding site [chemical binding]; other site 1327988005737 Walker B motif; other site 1327988005738 arginine finger; other site 1327988005739 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1327988005740 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1327988005741 Ligand Binding Site [chemical binding]; other site 1327988005742 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1327988005743 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1327988005744 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988005745 non-specific DNA binding site [nucleotide binding]; other site 1327988005746 salt bridge; other site 1327988005747 sequence-specific DNA binding site [nucleotide binding]; other site 1327988005748 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1327988005749 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1327988005750 putative active site [active] 1327988005751 catalytic site [active] 1327988005752 putative metal binding site [ion binding]; other site 1327988005753 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1327988005754 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1327988005755 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1327988005756 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1327988005757 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1327988005758 putative NAD(P) binding site [chemical binding]; other site 1327988005759 dimer interface [polypeptide binding]; other site 1327988005760 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1327988005761 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1327988005762 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1327988005763 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1327988005764 NAD binding site [chemical binding]; other site 1327988005765 dimer interface [polypeptide binding]; other site 1327988005766 substrate binding site [chemical binding]; other site 1327988005767 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1327988005768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988005769 dimer interface [polypeptide binding]; other site 1327988005770 conserved gate region; other site 1327988005771 ABC-ATPase subunit interface; other site 1327988005772 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1327988005773 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1327988005774 Walker A/P-loop; other site 1327988005775 ATP binding site [chemical binding]; other site 1327988005776 Q-loop/lid; other site 1327988005777 ABC transporter signature motif; other site 1327988005778 Walker B; other site 1327988005779 D-loop; other site 1327988005780 H-loop/switch region; other site 1327988005781 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1327988005782 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1327988005783 lipoyl attachment site [posttranslational modification]; other site 1327988005784 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1327988005785 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1327988005786 hypothetical protein; Validated; Region: PRK00041 1327988005787 rod shape-determining protein MreB; Provisional; Region: PRK13930 1327988005788 MreB and similar proteins; Region: MreB_like; cd10225 1327988005789 nucleotide binding site [chemical binding]; other site 1327988005790 Mg binding site [ion binding]; other site 1327988005791 putative protofilament interaction site [polypeptide binding]; other site 1327988005792 RodZ interaction site [polypeptide binding]; other site 1327988005793 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1327988005794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1327988005795 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1327988005796 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1327988005797 hinge; other site 1327988005798 active site 1327988005799 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1327988005800 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1327988005801 gamma subunit interface [polypeptide binding]; other site 1327988005802 epsilon subunit interface [polypeptide binding]; other site 1327988005803 LBP interface [polypeptide binding]; other site 1327988005804 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1327988005805 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1327988005806 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1327988005807 alpha subunit interaction interface [polypeptide binding]; other site 1327988005808 Walker A motif; other site 1327988005809 ATP binding site [chemical binding]; other site 1327988005810 Walker B motif; other site 1327988005811 inhibitor binding site; inhibition site 1327988005812 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1327988005813 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1327988005814 core domain interface [polypeptide binding]; other site 1327988005815 delta subunit interface [polypeptide binding]; other site 1327988005816 epsilon subunit interface [polypeptide binding]; other site 1327988005817 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1327988005818 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1327988005819 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1327988005820 beta subunit interaction interface [polypeptide binding]; other site 1327988005821 Walker A motif; other site 1327988005822 ATP binding site [chemical binding]; other site 1327988005823 Walker B motif; other site 1327988005824 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1327988005825 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1327988005826 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1327988005827 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1327988005828 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1327988005829 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1327988005830 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1327988005831 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1327988005832 uracil transporter; Provisional; Region: PRK10720 1327988005833 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1327988005834 active site 1327988005835 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1327988005836 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1327988005837 dimer interface [polypeptide binding]; other site 1327988005838 active site 1327988005839 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1327988005840 folate binding site [chemical binding]; other site 1327988005841 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1327988005842 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1327988005843 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1327988005844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1327988005845 S-adenosylmethionine binding site [chemical binding]; other site 1327988005846 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1327988005847 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1327988005848 RF-1 domain; Region: RF-1; pfam00472 1327988005849 thymidine kinase; Provisional; Region: PRK04296 1327988005850 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1327988005851 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1327988005852 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1327988005853 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1327988005854 catalytic triad [active] 1327988005855 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1327988005856 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1327988005857 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1327988005858 Beta-lactamase; Region: Beta-lactamase; pfam00144 1327988005859 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1327988005860 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1327988005861 homodimer interface [polypeptide binding]; other site 1327988005862 substrate-cofactor binding pocket; other site 1327988005863 catalytic residue [active] 1327988005864 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1327988005865 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1327988005866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988005867 Walker A/P-loop; other site 1327988005868 ATP binding site [chemical binding]; other site 1327988005869 Q-loop/lid; other site 1327988005870 ABC transporter signature motif; other site 1327988005871 Walker B; other site 1327988005872 D-loop; other site 1327988005873 H-loop/switch region; other site 1327988005874 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1327988005875 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1327988005876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988005877 Walker A/P-loop; other site 1327988005878 ATP binding site [chemical binding]; other site 1327988005879 Q-loop/lid; other site 1327988005880 ABC transporter signature motif; other site 1327988005881 Walker B; other site 1327988005882 D-loop; other site 1327988005883 H-loop/switch region; other site 1327988005884 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1327988005885 prophage1 1327988005886 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1327988005887 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1327988005888 putative active site [active] 1327988005889 putative metal binding site [ion binding]; other site 1327988005890 Abi-like protein; Region: Abi_2; pfam07751 1327988005891 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988005892 Helix-turn-helix domain; Region: HTH_38; pfam13936 1327988005893 Homeodomain-like domain; Region: HTH_32; pfam13565 1327988005894 Integrase core domain; Region: rve; pfam00665 1327988005895 Bacteriophage holin; Region: Phage_holin_1; cl02344 1327988005896 Haemolysin XhlA; Region: XhlA; pfam10779 1327988005897 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1327988005898 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1327988005899 active site 1327988005900 Bacterial SH3 domain; Region: SH3_5; pfam08460 1327988005901 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1327988005902 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1327988005903 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988005904 Helix-turn-helix domain; Region: HTH_38; pfam13936 1327988005905 Integrase core domain; Region: rve; pfam00665 1327988005906 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1327988005907 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1327988005908 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 1327988005909 Phage tail protein; Region: Sipho_tail; pfam05709 1327988005910 tape measure domain; Region: tape_meas_nterm; TIGR02675 1327988005911 membrane protein P6; Region: PHA01399 1327988005912 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1327988005913 Phage protein; Region: DUF3647; pfam12363 1327988005914 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 1327988005915 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 1327988005916 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1327988005917 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1327988005918 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1327988005919 Phage terminase large subunit; Region: Terminase_3; cl12054 1327988005920 Terminase-like family; Region: Terminase_6; pfam03237 1327988005921 Terminase small subunit; Region: Terminase_2; pfam03592 1327988005922 KTSC domain; Region: KTSC; pfam13619 1327988005923 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1327988005924 Probable pectinesterase/pectinesterase inhibitor; Region: PLN02713 1327988005925 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 1327988005926 AntA/AntB antirepressor; Region: AntA; pfam08346 1327988005927 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1327988005928 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 1327988005929 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1327988005930 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1327988005931 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1327988005932 dimer interface [polypeptide binding]; other site 1327988005933 ssDNA binding site [nucleotide binding]; other site 1327988005934 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1327988005935 ERF superfamily; Region: ERF; pfam04404 1327988005936 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1327988005937 non-specific DNA binding site [nucleotide binding]; other site 1327988005938 sequence-specific DNA binding site [nucleotide binding]; other site 1327988005939 salt bridge; other site 1327988005940 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988005941 non-specific DNA binding site [nucleotide binding]; other site 1327988005942 salt bridge; other site 1327988005943 sequence-specific DNA binding site [nucleotide binding]; other site 1327988005944 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1327988005945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988005946 non-specific DNA binding site [nucleotide binding]; other site 1327988005947 salt bridge; other site 1327988005948 sequence-specific DNA binding site [nucleotide binding]; other site 1327988005949 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1327988005950 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1327988005951 prophage2 1327988005952 Uncharacterized conserved protein [Function unknown]; Region: COG4127 1327988005953 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1327988005954 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1327988005955 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1327988005956 Int/Topo IB signature motif; other site 1327988005957 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1327988005958 oligomerization interface [polypeptide binding]; other site 1327988005959 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1327988005960 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1327988005961 Phage capsid family; Region: Phage_capsid; pfam05065 1327988005962 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1327988005963 Phage Terminase; Region: Terminase_1; pfam03354 1327988005964 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1327988005965 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1327988005966 active site 1327988005967 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1327988005968 Virulence-associated protein E; Region: VirE; pfam05272 1327988005969 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1327988005970 polymerase nucleotide-binding site; other site 1327988005971 DNA-binding residues [nucleotide binding]; DNA binding site 1327988005972 nucleotide binding site [chemical binding]; other site 1327988005973 primase nucleotide-binding site [nucleotide binding]; other site 1327988005974 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 1327988005975 Helix-turn-helix domain; Region: HTH_17; pfam12728 1327988005976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988005977 non-specific DNA binding site [nucleotide binding]; other site 1327988005978 salt bridge; other site 1327988005979 sequence-specific DNA binding site [nucleotide binding]; other site 1327988005980 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988005981 Helix-turn-helix domain; Region: HTH_38; pfam13936 1327988005982 Homeodomain-like domain; Region: HTH_32; pfam13565 1327988005983 Integrase core domain; Region: rve; pfam00665 1327988005984 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1327988005985 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1327988005986 Int/Topo IB signature motif; other site 1327988005987 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1327988005988 MarR family; Region: MarR_2; pfam12802 1327988005989 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1327988005990 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1327988005991 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988005992 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988005993 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988005994 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988005995 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988005996 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1327988005997 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1327988005998 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988005999 Walker A/P-loop; other site 1327988006000 ATP binding site [chemical binding]; other site 1327988006001 Q-loop/lid; other site 1327988006002 ABC transporter signature motif; other site 1327988006003 Walker B; other site 1327988006004 D-loop; other site 1327988006005 H-loop/switch region; other site 1327988006006 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1327988006007 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1327988006008 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1327988006009 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1327988006010 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1327988006011 Walker A/P-loop; other site 1327988006012 ATP binding site [chemical binding]; other site 1327988006013 Q-loop/lid; other site 1327988006014 ABC transporter signature motif; other site 1327988006015 Walker B; other site 1327988006016 D-loop; other site 1327988006017 H-loop/switch region; other site 1327988006018 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1327988006019 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1327988006020 FtsX-like permease family; Region: FtsX; pfam02687 1327988006021 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1327988006022 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1327988006023 active site 1327988006024 dimer interface [polypeptide binding]; other site 1327988006025 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1327988006026 dimer interface [polypeptide binding]; other site 1327988006027 active site 1327988006028 Sugar transport protein; Region: Sugar_transport; pfam06800 1327988006029 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1327988006030 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1327988006031 putative RNA binding site [nucleotide binding]; other site 1327988006032 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1327988006033 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1327988006034 dimerization interface [polypeptide binding]; other site 1327988006035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1327988006036 dimer interface [polypeptide binding]; other site 1327988006037 phosphorylation site [posttranslational modification] 1327988006038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1327988006039 ATP binding site [chemical binding]; other site 1327988006040 Mg2+ binding site [ion binding]; other site 1327988006041 G-X-G motif; other site 1327988006042 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1327988006043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1327988006044 active site 1327988006045 phosphorylation site [posttranslational modification] 1327988006046 intermolecular recognition site; other site 1327988006047 dimerization interface [polypeptide binding]; other site 1327988006048 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1327988006049 DNA binding site [nucleotide binding] 1327988006050 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1327988006051 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1327988006052 EamA-like transporter family; Region: EamA; pfam00892 1327988006053 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1327988006054 EamA-like transporter family; Region: EamA; pfam00892 1327988006055 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1327988006056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988006057 benzoate transport; Region: 2A0115; TIGR00895 1327988006058 putative substrate translocation pore; other site 1327988006059 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1327988006060 nudix motif; other site 1327988006061 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1327988006062 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1327988006063 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1327988006064 NlpC/P60 family; Region: NLPC_P60; pfam00877 1327988006065 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1327988006066 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1327988006067 putative DNA binding site [nucleotide binding]; other site 1327988006068 putative Zn2+ binding site [ion binding]; other site 1327988006069 AsnC family; Region: AsnC_trans_reg; pfam01037 1327988006070 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1327988006071 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1327988006072 metal binding site [ion binding]; metal-binding site 1327988006073 active site 1327988006074 I-site; other site 1327988006075 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1327988006076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988006077 Walker A/P-loop; other site 1327988006078 ATP binding site [chemical binding]; other site 1327988006079 Q-loop/lid; other site 1327988006080 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1327988006081 ABC transporter signature motif; other site 1327988006082 Walker B; other site 1327988006083 D-loop; other site 1327988006084 ABC transporter; Region: ABC_tran_2; pfam12848 1327988006085 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1327988006086 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1327988006087 Coenzyme A binding pocket [chemical binding]; other site 1327988006088 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1327988006089 dimer interface [polypeptide binding]; other site 1327988006090 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1327988006091 metal binding site [ion binding]; metal-binding site 1327988006092 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1327988006093 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1327988006094 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1327988006095 active site turn [active] 1327988006096 phosphorylation site [posttranslational modification] 1327988006097 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1327988006098 HPr interaction site; other site 1327988006099 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1327988006100 active site 1327988006101 phosphorylation site [posttranslational modification] 1327988006102 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1327988006103 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1327988006104 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1327988006105 EDD domain protein, DegV family; Region: DegV; TIGR00762 1327988006106 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1327988006107 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 1327988006108 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1327988006109 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1327988006110 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1327988006111 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1327988006112 homodimer interface [polypeptide binding]; other site 1327988006113 substrate-cofactor binding pocket; other site 1327988006114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988006115 catalytic residue [active] 1327988006116 Homoserine O-succinyltransferase; Region: HTS; pfam04204 1327988006117 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1327988006118 proposed active site lysine [active] 1327988006119 conserved cys residue [active] 1327988006120 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1327988006121 zinc binding site [ion binding]; other site 1327988006122 putative ligand binding site [chemical binding]; other site 1327988006123 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1327988006124 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1327988006125 TM-ABC transporter signature motif; other site 1327988006126 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1327988006127 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988006128 Walker A/P-loop; other site 1327988006129 ATP binding site [chemical binding]; other site 1327988006130 Q-loop/lid; other site 1327988006131 ABC transporter signature motif; other site 1327988006132 Walker B; other site 1327988006133 D-loop; other site 1327988006134 H-loop/switch region; other site 1327988006135 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1327988006136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1327988006137 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1327988006138 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1327988006139 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1327988006140 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1327988006141 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1327988006142 maltose O-acetyltransferase; Provisional; Region: PRK10092 1327988006143 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1327988006144 active site 1327988006145 substrate binding site [chemical binding]; other site 1327988006146 trimer interface [polypeptide binding]; other site 1327988006147 CoA binding site [chemical binding]; other site 1327988006148 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1327988006149 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1327988006150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988006151 homodimer interface [polypeptide binding]; other site 1327988006152 catalytic residue [active] 1327988006153 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1327988006154 metal binding site [ion binding]; metal-binding site 1327988006155 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; pfam01502 1327988006156 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1327988006157 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1327988006158 substrate binding site [chemical binding]; other site 1327988006159 glutamase interaction surface [polypeptide binding]; other site 1327988006160 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1327988006161 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1327988006162 catalytic residues [active] 1327988006163 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1327988006164 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1327988006165 putative active site [active] 1327988006166 oxyanion strand; other site 1327988006167 catalytic triad [active] 1327988006168 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1327988006169 putative active site pocket [active] 1327988006170 4-fold oligomerization interface [polypeptide binding]; other site 1327988006171 metal binding residues [ion binding]; metal-binding site 1327988006172 3-fold/trimer interface [polypeptide binding]; other site 1327988006173 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1327988006174 histidinol dehydrogenase; Region: hisD; TIGR00069 1327988006175 NAD binding site [chemical binding]; other site 1327988006176 dimerization interface [polypeptide binding]; other site 1327988006177 product binding site; other site 1327988006178 substrate binding site [chemical binding]; other site 1327988006179 zinc binding site [ion binding]; other site 1327988006180 catalytic residues [active] 1327988006181 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1327988006182 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1327988006183 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 1327988006184 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1327988006185 dimer interface [polypeptide binding]; other site 1327988006186 motif 1; other site 1327988006187 active site 1327988006188 motif 2; other site 1327988006189 motif 3; other site 1327988006190 histidinol-phosphatase; Reviewed; Region: PRK08123 1327988006191 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1327988006192 active site 1327988006193 dimer interface [polypeptide binding]; other site 1327988006194 VanZ like family; Region: VanZ; pfam04892 1327988006195 RDD family; Region: RDD; pfam06271 1327988006196 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1327988006197 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1327988006198 Cl binding site [ion binding]; other site 1327988006199 oligomer interface [polypeptide binding]; other site 1327988006200 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1327988006201 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1327988006202 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1327988006203 DNA binding residues [nucleotide binding] 1327988006204 putative dimer interface [polypeptide binding]; other site 1327988006205 short chain dehydrogenase; Provisional; Region: PRK06180 1327988006206 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1327988006207 NADP binding site [chemical binding]; other site 1327988006208 active site 1327988006209 steroid binding site; other site 1327988006210 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1327988006211 hydrophobic ligand binding site; other site 1327988006212 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1327988006213 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1327988006214 Peptidase M15; Region: Peptidase_M15_3; cl01194 1327988006215 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1327988006216 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1327988006217 active site 1327988006218 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 1327988006219 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1327988006220 Collagen binding domain; Region: Collagen_bind; pfam05737 1327988006221 Cna protein B-type domain; Region: Cna_B; pfam05738 1327988006222 Cna protein B-type domain; Region: Cna_B; pfam05738 1327988006223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1327988006224 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1327988006225 Coenzyme A binding pocket [chemical binding]; other site 1327988006226 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1327988006227 Sulfatase; Region: Sulfatase; pfam00884 1327988006228 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 1327988006229 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1327988006230 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1327988006231 putative active site [active] 1327988006232 catalytic site [active] 1327988006233 putative metal binding site [ion binding]; other site 1327988006234 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1327988006235 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1327988006236 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1327988006237 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1327988006238 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1327988006239 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1327988006240 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1327988006241 dimer interface [polypeptide binding]; other site 1327988006242 FMN binding site [chemical binding]; other site 1327988006243 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1327988006244 active site 1327988006245 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 1327988006246 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1327988006247 RNA/DNA hybrid binding site [nucleotide binding]; other site 1327988006248 active site 1327988006249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988006250 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1327988006251 active site 1327988006252 motif I; other site 1327988006253 motif II; other site 1327988006254 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988006255 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1327988006256 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1327988006257 DNA binding site [nucleotide binding] 1327988006258 domain linker motif; other site 1327988006259 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1327988006260 putative dimerization interface [polypeptide binding]; other site 1327988006261 putative ligand binding site [chemical binding]; other site 1327988006262 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1327988006263 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1327988006264 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1327988006265 putative active site [active] 1327988006266 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1327988006267 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1327988006268 putative oxidoreductase; Provisional; Region: PRK10206 1327988006269 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1327988006270 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1327988006271 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1327988006272 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1327988006273 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 1327988006274 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1327988006275 TPP-binding site; other site 1327988006276 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1327988006277 PYR/PP interface [polypeptide binding]; other site 1327988006278 dimer interface [polypeptide binding]; other site 1327988006279 TPP binding site [chemical binding]; other site 1327988006280 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1327988006281 Isochorismatase family; Region: Isochorismatase; pfam00857 1327988006282 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1327988006283 catalytic triad [active] 1327988006284 conserved cis-peptide bond; other site 1327988006285 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1327988006286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988006287 Walker A/P-loop; other site 1327988006288 ATP binding site [chemical binding]; other site 1327988006289 Q-loop/lid; other site 1327988006290 ABC transporter signature motif; other site 1327988006291 Walker B; other site 1327988006292 D-loop; other site 1327988006293 H-loop/switch region; other site 1327988006294 Predicted transcriptional regulators [Transcription]; Region: COG1725 1327988006295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1327988006296 DNA-binding site [nucleotide binding]; DNA binding site 1327988006297 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1327988006298 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1327988006299 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1327988006300 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1327988006301 active site 1327988006302 Zn binding site [ion binding]; other site 1327988006303 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1327988006304 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988006305 non-specific DNA binding site [nucleotide binding]; other site 1327988006306 salt bridge; other site 1327988006307 sequence-specific DNA binding site [nucleotide binding]; other site 1327988006308 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 1327988006309 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1327988006310 PYR/PP interface [polypeptide binding]; other site 1327988006311 dimer interface [polypeptide binding]; other site 1327988006312 tetramer interface [polypeptide binding]; other site 1327988006313 TPP binding site [chemical binding]; other site 1327988006314 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1327988006315 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1327988006316 TPP-binding site [chemical binding]; other site 1327988006317 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1327988006318 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1327988006319 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1327988006320 catalytic residues [active] 1327988006321 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1327988006322 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1327988006323 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1327988006324 catalytic residue [active] 1327988006325 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 1327988006326 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1327988006327 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1327988006328 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1327988006329 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1327988006330 Bacterial SH3 domain; Region: SH3_5; pfam08460 1327988006331 Bacterial SH3 domain; Region: SH3_5; pfam08460 1327988006332 Bacterial SH3 domain; Region: SH3_5; pfam08460 1327988006333 Bacterial SH3 domain; Region: SH3_5; pfam08460 1327988006334 Bacterial SH3 domain; Region: SH3_5; pfam08460 1327988006335 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1327988006336 Ligand Binding Site [chemical binding]; other site 1327988006337 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1327988006338 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1327988006339 active site 1327988006340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988006341 non-specific DNA binding site [nucleotide binding]; other site 1327988006342 salt bridge; other site 1327988006343 sequence-specific DNA binding site [nucleotide binding]; other site 1327988006344 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1327988006345 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1327988006346 putative ADP-binding pocket [chemical binding]; other site 1327988006347 putative phosphoketolase; Provisional; Region: PRK05261 1327988006348 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1327988006349 TPP-binding site; other site 1327988006350 XFP C-terminal domain; Region: XFP_C; pfam09363 1327988006351 Predicted esterase [General function prediction only]; Region: COG0627 1327988006352 S-formylglutathione hydrolase; Region: PLN02442 1327988006353 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1327988006354 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1327988006355 DNA-binding site [nucleotide binding]; DNA binding site 1327988006356 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1327988006357 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1327988006358 putative deacylase active site [active] 1327988006359 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1327988006360 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1327988006361 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1327988006362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1327988006363 active site 1327988006364 phosphorylation site [posttranslational modification] 1327988006365 intermolecular recognition site; other site 1327988006366 dimerization interface [polypeptide binding]; other site 1327988006367 LytTr DNA-binding domain; Region: LytTR; pfam04397 1327988006368 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1327988006369 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1327988006370 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1327988006371 putative dimer interface [polypeptide binding]; other site 1327988006372 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1327988006373 Domain of unknown function DUF21; Region: DUF21; pfam01595 1327988006374 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1327988006375 Transporter associated domain; Region: CorC_HlyC; smart01091 1327988006376 flavoprotein NrdI; Provisional; Region: PRK02551 1327988006377 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1327988006378 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1327988006379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988006380 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988006381 putative substrate translocation pore; other site 1327988006382 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1327988006383 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1327988006384 DNA binding residues [nucleotide binding] 1327988006385 putative dimer interface [polypeptide binding]; other site 1327988006386 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1327988006387 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1327988006388 putative NAD(P) binding site [chemical binding]; other site 1327988006389 SdpI/YhfL protein family; Region: SdpI; pfam13630 1327988006390 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1327988006391 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1327988006392 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1327988006393 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1327988006394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1327988006395 DNA-binding site [nucleotide binding]; DNA binding site 1327988006396 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1327988006397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988006398 homodimer interface [polypeptide binding]; other site 1327988006399 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1327988006400 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1327988006401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988006402 homodimer interface [polypeptide binding]; other site 1327988006403 catalytic residue [active] 1327988006404 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1327988006405 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1327988006406 dimer interface [polypeptide binding]; other site 1327988006407 active site 1327988006408 catalytic residue [active] 1327988006409 hypothetical protein; Provisional; Region: PRK10621 1327988006410 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1327988006411 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988006412 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1327988006413 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1327988006414 dimerization interface [polypeptide binding]; other site 1327988006415 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1327988006416 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1327988006417 NAD(P) binding site [chemical binding]; other site 1327988006418 putative active site [active] 1327988006419 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1327988006420 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1327988006421 Part of AAA domain; Region: AAA_19; pfam13245 1327988006422 Family description; Region: UvrD_C_2; pfam13538 1327988006423 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1327988006424 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1327988006425 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1327988006426 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1327988006427 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1327988006428 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1327988006429 active site 1327988006430 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1327988006431 active site 1327988006432 dimer interface [polypeptide binding]; other site 1327988006433 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1327988006434 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1327988006435 heterodimer interface [polypeptide binding]; other site 1327988006436 active site 1327988006437 FMN binding site [chemical binding]; other site 1327988006438 homodimer interface [polypeptide binding]; other site 1327988006439 substrate binding site [chemical binding]; other site 1327988006440 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1327988006441 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1327988006442 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1327988006443 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1327988006444 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1327988006445 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1327988006446 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1327988006447 IMP binding site; other site 1327988006448 dimer interface [polypeptide binding]; other site 1327988006449 interdomain contacts; other site 1327988006450 partial ornithine binding site; other site 1327988006451 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1327988006452 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1327988006453 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1327988006454 catalytic site [active] 1327988006455 subunit interface [polypeptide binding]; other site 1327988006456 dihydroorotase; Validated; Region: pyrC; PRK09357 1327988006457 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1327988006458 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1327988006459 active site 1327988006460 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1327988006461 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1327988006462 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1327988006463 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1327988006464 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1327988006465 active site 1327988006466 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1327988006467 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1327988006468 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1327988006469 xanthine permease; Region: pbuX; TIGR03173 1327988006470 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1327988006471 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1327988006472 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1327988006473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1327988006474 NAD(P) binding site [chemical binding]; other site 1327988006475 active site 1327988006476 EAL domain; Region: EAL; pfam00563 1327988006477 N-glycosyltransferase; Provisional; Region: PRK11204 1327988006478 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1327988006479 DXD motif; other site 1327988006480 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1327988006481 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1327988006482 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1327988006483 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1327988006484 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1327988006485 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1327988006486 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1327988006487 purine monophosphate binding site [chemical binding]; other site 1327988006488 dimer interface [polypeptide binding]; other site 1327988006489 putative catalytic residues [active] 1327988006490 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1327988006491 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1327988006492 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1327988006493 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1327988006494 active site 1327988006495 substrate binding site [chemical binding]; other site 1327988006496 cosubstrate binding site; other site 1327988006497 catalytic site [active] 1327988006498 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1327988006499 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1327988006500 dimerization interface [polypeptide binding]; other site 1327988006501 putative ATP binding site [chemical binding]; other site 1327988006502 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1327988006503 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1327988006504 active site 1327988006505 tetramer interface [polypeptide binding]; other site 1327988006506 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1327988006507 active site 1327988006508 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1327988006509 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1327988006510 dimerization interface [polypeptide binding]; other site 1327988006511 ATP binding site [chemical binding]; other site 1327988006512 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1327988006513 dimerization interface [polypeptide binding]; other site 1327988006514 ATP binding site [chemical binding]; other site 1327988006515 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1327988006516 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1327988006517 putative active site [active] 1327988006518 catalytic triad [active] 1327988006519 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1327988006520 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1327988006521 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1327988006522 ATP binding site [chemical binding]; other site 1327988006523 active site 1327988006524 substrate binding site [chemical binding]; other site 1327988006525 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1327988006526 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1327988006527 NAD binding site [chemical binding]; other site 1327988006528 ATP-grasp domain; Region: ATP-grasp; pfam02222 1327988006529 AIR carboxylase; Region: AIRC; pfam00731 1327988006530 Predicted flavoprotein [General function prediction only]; Region: COG0431 1327988006531 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1327988006532 PAS domain; Region: PAS_10; pfam13596 1327988006533 Predicted flavoprotein [General function prediction only]; Region: COG0431 1327988006534 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1327988006535 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1327988006536 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1327988006537 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1327988006538 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1327988006539 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1327988006540 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1327988006541 active site 1327988006542 zinc binding site [ion binding]; other site 1327988006543 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1327988006544 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1327988006545 active site 1327988006546 homotetramer interface [polypeptide binding]; other site 1327988006547 homodimer interface [polypeptide binding]; other site 1327988006548 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1327988006549 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1327988006550 Walker A/P-loop; other site 1327988006551 ATP binding site [chemical binding]; other site 1327988006552 Q-loop/lid; other site 1327988006553 ABC transporter signature motif; other site 1327988006554 Walker B; other site 1327988006555 D-loop; other site 1327988006556 H-loop/switch region; other site 1327988006557 FtsX-like permease family; Region: FtsX; pfam02687 1327988006558 Predicted transcriptional regulators [Transcription]; Region: COG1725 1327988006559 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1327988006560 DNA-binding site [nucleotide binding]; DNA binding site 1327988006561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988006562 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1327988006563 Walker A/P-loop; other site 1327988006564 ATP binding site [chemical binding]; other site 1327988006565 Q-loop/lid; other site 1327988006566 ABC transporter signature motif; other site 1327988006567 Walker B; other site 1327988006568 D-loop; other site 1327988006569 H-loop/switch region; other site 1327988006570 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1327988006571 Ligand Binding Site [chemical binding]; other site 1327988006572 Predicted membrane protein [Function unknown]; Region: COG2246 1327988006573 GtrA-like protein; Region: GtrA; pfam04138 1327988006574 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1327988006575 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1327988006576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988006577 homodimer interface [polypeptide binding]; other site 1327988006578 catalytic residue [active] 1327988006579 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1327988006580 homodimer interface [polypeptide binding]; other site 1327988006581 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1327988006582 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1327988006583 active site 1327988006584 homodimer interface [polypeptide binding]; other site 1327988006585 catalytic site [active] 1327988006586 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1327988006587 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1327988006588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988006589 catalytic residue [active] 1327988006590 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1327988006591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988006592 active site 1327988006593 motif I; other site 1327988006594 motif II; other site 1327988006595 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1327988006596 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1327988006597 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1327988006598 maltose O-acetyltransferase; Provisional; Region: PRK10092 1327988006599 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1327988006600 active site 1327988006601 substrate binding site [chemical binding]; other site 1327988006602 trimer interface [polypeptide binding]; other site 1327988006603 CoA binding site [chemical binding]; other site 1327988006604 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1327988006605 dimer interface [polypeptide binding]; other site 1327988006606 ADP-ribose binding site [chemical binding]; other site 1327988006607 active site 1327988006608 nudix motif; other site 1327988006609 metal binding site [ion binding]; metal-binding site 1327988006610 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1327988006611 nucleotide binding site/active site [active] 1327988006612 HIT family signature motif; other site 1327988006613 catalytic residue [active] 1327988006614 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 1327988006615 classical (c) SDRs; Region: SDR_c; cd05233 1327988006616 NAD(P) binding site [chemical binding]; other site 1327988006617 active site 1327988006618 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1327988006619 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1327988006620 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1327988006621 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1327988006622 Sterol carrier protein domain; Region: SCP2_2; pfam13530 1327988006623 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1327988006624 HTH domain; Region: HTH_11; pfam08279 1327988006625 3H domain; Region: 3H; pfam02829 1327988006626 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1327988006627 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1327988006628 active site 1327988006629 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988006630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988006631 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1327988006632 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1327988006633 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1327988006634 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1327988006635 Walker A/P-loop; other site 1327988006636 ATP binding site [chemical binding]; other site 1327988006637 Q-loop/lid; other site 1327988006638 ABC transporter signature motif; other site 1327988006639 Walker B; other site 1327988006640 D-loop; other site 1327988006641 H-loop/switch region; other site 1327988006642 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1327988006643 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1327988006644 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1327988006645 catalytic residue [active] 1327988006646 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1327988006647 beta-galactosidase; Region: BGL; TIGR03356 1327988006648 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1327988006649 beta-galactosidase; Region: BGL; TIGR03356 1327988006650 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1327988006651 active site 1327988006652 methionine cluster; other site 1327988006653 phosphorylation site [posttranslational modification] 1327988006654 metal binding site [ion binding]; metal-binding site 1327988006655 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1327988006656 active site 1327988006657 P-loop; other site 1327988006658 phosphorylation site [posttranslational modification] 1327988006659 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1327988006660 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1327988006661 DNA-binding site [nucleotide binding]; DNA binding site 1327988006662 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1327988006663 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1327988006664 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1327988006665 active site 1327988006666 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1327988006667 catalytic core [active] 1327988006668 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1327988006669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988006670 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1327988006671 active site 1327988006672 motif I; other site 1327988006673 motif II; other site 1327988006674 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1327988006675 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1327988006676 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1327988006677 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1327988006678 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1327988006679 EamA-like transporter family; Region: EamA; pfam00892 1327988006680 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1327988006681 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 1327988006682 putative ligand binding site [chemical binding]; other site 1327988006683 NAD binding site [chemical binding]; other site 1327988006684 catalytic site [active] 1327988006685 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1327988006686 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1327988006687 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1327988006688 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1327988006689 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1327988006690 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1327988006691 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1327988006692 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1327988006693 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1327988006694 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1327988006695 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1327988006696 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1327988006697 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1327988006698 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1327988006699 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1327988006700 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1327988006701 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1327988006702 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1327988006703 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1327988006704 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1327988006705 active site 1327988006706 catalytic residue [active] 1327988006707 dimer interface [polypeptide binding]; other site 1327988006708 inner membrane transporter YjeM; Provisional; Region: PRK15238 1327988006709 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1327988006710 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1327988006711 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1327988006712 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1327988006713 active site 1327988006714 catalytic tetrad [active] 1327988006715 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1327988006716 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1327988006717 active site 1327988006718 catalytic tetrad [active] 1327988006719 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988006720 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1327988006721 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1327988006722 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1327988006723 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1327988006724 active site 1327988006725 HIGH motif; other site 1327988006726 dimer interface [polypeptide binding]; other site 1327988006727 KMSKS motif; other site 1327988006728 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1327988006729 RNA binding surface [nucleotide binding]; other site 1327988006730 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1327988006731 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1327988006732 active site 1327988006733 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1327988006734 putative active site [active] 1327988006735 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1327988006736 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1327988006737 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1327988006738 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1327988006739 DNA binding residues [nucleotide binding] 1327988006740 drug binding residues [chemical binding]; other site 1327988006741 dimer interface [polypeptide binding]; other site 1327988006742 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1327988006743 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1327988006744 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1327988006745 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 1327988006746 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1327988006747 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1327988006748 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1327988006749 Walker A/P-loop; other site 1327988006750 ATP binding site [chemical binding]; other site 1327988006751 Q-loop/lid; other site 1327988006752 ABC transporter signature motif; other site 1327988006753 Walker B; other site 1327988006754 D-loop; other site 1327988006755 H-loop/switch region; other site 1327988006756 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1327988006757 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1327988006758 active site 1327988006759 RibD C-terminal domain; Region: RibD_C; cl17279 1327988006760 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1327988006761 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1327988006762 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1327988006763 Predicted permeases [General function prediction only]; Region: COG0679 1327988006764 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1327988006765 Aspartase; Region: Aspartase; cd01357 1327988006766 active sites [active] 1327988006767 tetramer interface [polypeptide binding]; other site 1327988006768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988006769 putative substrate translocation pore; other site 1327988006770 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1327988006771 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1327988006772 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1327988006773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988006774 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988006775 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1327988006776 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1327988006777 Predicted membrane protein [Function unknown]; Region: COG2855 1327988006778 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988006779 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1327988006780 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1327988006781 dimerization interface [polypeptide binding]; other site 1327988006782 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1327988006783 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1327988006784 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1327988006785 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1327988006786 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1327988006787 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1327988006788 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1327988006789 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1327988006790 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1327988006791 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1327988006792 DNA binding site [nucleotide binding] 1327988006793 active site 1327988006794 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1327988006795 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988006796 Walker A/P-loop; other site 1327988006797 ATP binding site [chemical binding]; other site 1327988006798 Q-loop/lid; other site 1327988006799 ABC transporter signature motif; other site 1327988006800 Walker B; other site 1327988006801 D-loop; other site 1327988006802 H-loop/switch region; other site 1327988006803 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1327988006804 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1327988006805 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1327988006806 classical (c) SDRs; Region: SDR_c; cd05233 1327988006807 NAD(P) binding site [chemical binding]; other site 1327988006808 active site 1327988006809 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1327988006810 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1327988006811 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1327988006812 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1327988006813 DNA binding residues [nucleotide binding] 1327988006814 putative dimer interface [polypeptide binding]; other site 1327988006815 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1327988006816 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1327988006817 metal binding site [ion binding]; metal-binding site 1327988006818 dimer interface [polypeptide binding]; other site 1327988006819 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1327988006820 FtsX-like permease family; Region: FtsX; pfam02687 1327988006821 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1327988006822 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1327988006823 FtsX-like permease family; Region: FtsX; pfam02687 1327988006824 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1327988006825 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1327988006826 Walker A/P-loop; other site 1327988006827 ATP binding site [chemical binding]; other site 1327988006828 Q-loop/lid; other site 1327988006829 ABC transporter signature motif; other site 1327988006830 Walker B; other site 1327988006831 D-loop; other site 1327988006832 H-loop/switch region; other site 1327988006833 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1327988006834 endonuclease III; Region: ENDO3c; smart00478 1327988006835 minor groove reading motif; other site 1327988006836 helix-hairpin-helix signature motif; other site 1327988006837 substrate binding pocket [chemical binding]; other site 1327988006838 active site 1327988006839 maltose O-acetyltransferase; Provisional; Region: PRK10092 1327988006840 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1327988006841 active site 1327988006842 substrate binding site [chemical binding]; other site 1327988006843 trimer interface [polypeptide binding]; other site 1327988006844 CoA binding site [chemical binding]; other site 1327988006845 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1327988006846 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1327988006847 Catalytic site [active] 1327988006848 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1327988006849 PYR/PP interface [polypeptide binding]; other site 1327988006850 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1327988006851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1327988006852 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1327988006853 Coenzyme A binding pocket [chemical binding]; other site 1327988006854 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1327988006855 catalytic core [active] 1327988006856 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988006857 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1327988006858 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1327988006859 dimerization interface [polypeptide binding]; other site 1327988006860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1327988006861 NAD(P) binding site [chemical binding]; other site 1327988006862 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1327988006863 active site 1327988006864 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1327988006865 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1327988006866 catalytic Zn binding site [ion binding]; other site 1327988006867 NAD(P) binding site [chemical binding]; other site 1327988006868 structural Zn binding site [ion binding]; other site 1327988006869 short chain dehydrogenase; Provisional; Region: PRK06940 1327988006870 classical (c) SDRs; Region: SDR_c; cd05233 1327988006871 NAD(P) binding site [chemical binding]; other site 1327988006872 active site 1327988006873 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1327988006874 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1327988006875 Ligand Binding Site [chemical binding]; other site 1327988006876 maltose O-acetyltransferase; Provisional; Region: PRK10092 1327988006877 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1327988006878 active site 1327988006879 substrate binding site [chemical binding]; other site 1327988006880 trimer interface [polypeptide binding]; other site 1327988006881 CoA binding site [chemical binding]; other site 1327988006882 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1327988006883 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988006884 motif II; other site 1327988006885 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1327988006886 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1327988006887 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1327988006888 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1327988006889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988006890 homodimer interface [polypeptide binding]; other site 1327988006891 catalytic residue [active] 1327988006892 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 1327988006893 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1327988006894 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1327988006895 active site 1327988006896 catalytic tetrad [active] 1327988006897 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1327988006898 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1327988006899 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1327988006900 Walker A/P-loop; other site 1327988006901 ATP binding site [chemical binding]; other site 1327988006902 Q-loop/lid; other site 1327988006903 ABC transporter signature motif; other site 1327988006904 Walker B; other site 1327988006905 D-loop; other site 1327988006906 H-loop/switch region; other site 1327988006907 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1327988006908 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1327988006909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988006910 Walker A/P-loop; other site 1327988006911 ATP binding site [chemical binding]; other site 1327988006912 Q-loop/lid; other site 1327988006913 ABC transporter signature motif; other site 1327988006914 Walker B; other site 1327988006915 D-loop; other site 1327988006916 H-loop/switch region; other site 1327988006917 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1327988006918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988006919 Predicted membrane protein [Function unknown]; Region: COG1511 1327988006920 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1327988006921 Predicted membrane protein [Function unknown]; Region: COG1511 1327988006922 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1327988006923 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1327988006924 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988006925 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988006926 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1327988006927 dimerization interface [polypeptide binding]; other site 1327988006928 putative DNA binding site [nucleotide binding]; other site 1327988006929 putative Zn2+ binding site [ion binding]; other site 1327988006930 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1327988006931 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1327988006932 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1327988006933 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1327988006934 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1327988006935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1327988006936 CAAX protease self-immunity; Region: Abi; pfam02517 1327988006937 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1327988006938 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1327988006939 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1327988006940 ABC transporter; Region: ABC_tran_2; pfam12848 1327988006941 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1327988006942 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988006943 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1327988006944 active site 1327988006945 motif I; other site 1327988006946 motif II; other site 1327988006947 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988006948 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1327988006949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988006950 Walker A/P-loop; other site 1327988006951 ATP binding site [chemical binding]; other site 1327988006952 Q-loop/lid; other site 1327988006953 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1327988006954 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1327988006955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988006956 ABC transporter signature motif; other site 1327988006957 Walker B; other site 1327988006958 D-loop; other site 1327988006959 H-loop/switch region; other site 1327988006960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988006961 Walker A/P-loop; other site 1327988006962 ATP binding site [chemical binding]; other site 1327988006963 Q-loop/lid; other site 1327988006964 ABC transporter signature motif; other site 1327988006965 Walker B; other site 1327988006966 D-loop; other site 1327988006967 H-loop/switch region; other site 1327988006968 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1327988006969 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988006970 non-specific DNA binding site [nucleotide binding]; other site 1327988006971 salt bridge; other site 1327988006972 sequence-specific DNA binding site [nucleotide binding]; other site 1327988006973 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1327988006974 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1327988006975 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1327988006976 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1327988006977 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1327988006978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1327988006979 DNA-binding site [nucleotide binding]; DNA binding site 1327988006980 UTRA domain; Region: UTRA; pfam07702 1327988006981 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1327988006982 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1327988006983 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 1327988006984 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1327988006985 HPr interaction site; other site 1327988006986 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1327988006987 active site 1327988006988 phosphorylation site [posttranslational modification] 1327988006989 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1327988006990 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1327988006991 metal binding site [ion binding]; metal-binding site 1327988006992 active site 1327988006993 I-site; other site 1327988006994 EAL domain; Region: EAL; pfam00563 1327988006995 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1327988006996 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1327988006997 FeS/SAM binding site; other site 1327988006998 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1327988006999 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1327988007000 effector binding site; other site 1327988007001 active site 1327988007002 Zn binding site [ion binding]; other site 1327988007003 glycine loop; other site 1327988007004 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1327988007005 active site 1327988007006 catalytic residues [active] 1327988007007 metal binding site [ion binding]; metal-binding site 1327988007008 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1327988007009 ApbE family; Region: ApbE; pfam02424 1327988007010 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1327988007011 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1327988007012 FMN binding site [chemical binding]; other site 1327988007013 active site 1327988007014 catalytic residues [active] 1327988007015 substrate binding site [chemical binding]; other site 1327988007016 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1327988007017 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988007018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1327988007019 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1327988007020 dimerization interface [polypeptide binding]; other site 1327988007021 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1327988007022 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1327988007023 transmembrane helices; other site 1327988007024 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1327988007025 Predicted membrane protein [Function unknown]; Region: COG4640 1327988007026 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1327988007027 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 1327988007028 Double zinc ribbon; Region: DZR; pfam12773 1327988007029 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1327988007030 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1327988007031 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1327988007032 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1327988007033 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1327988007034 Collagen binding domain; Region: Collagen_bind; pfam05737 1327988007035 EamA-like transporter family; Region: EamA; pfam00892 1327988007036 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1327988007037 EamA-like transporter family; Region: EamA; pfam00892 1327988007038 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1327988007039 catalytic triad [active] 1327988007040 catalytic triad [active] 1327988007041 oxyanion hole [active] 1327988007042 Amidohydrolase; Region: Amidohydro_2; pfam04909 1327988007043 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988007044 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1327988007045 Predicted transcriptional regulators [Transcription]; Region: COG1733 1327988007046 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1327988007047 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1327988007048 nucleotide binding site [chemical binding]; other site 1327988007049 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1327988007050 active site 1327988007051 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1327988007052 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1327988007053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988007054 Walker A/P-loop; other site 1327988007055 ATP binding site [chemical binding]; other site 1327988007056 Q-loop/lid; other site 1327988007057 ABC transporter signature motif; other site 1327988007058 Walker B; other site 1327988007059 D-loop; other site 1327988007060 H-loop/switch region; other site 1327988007061 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1327988007062 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1327988007063 putative Zn2+ binding site [ion binding]; other site 1327988007064 putative DNA binding site [nucleotide binding]; other site 1327988007065 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1327988007066 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1327988007067 DNA binding site [nucleotide binding] 1327988007068 domain linker motif; other site 1327988007069 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1327988007070 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1327988007071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988007072 active site 1327988007073 motif I; other site 1327988007074 motif II; other site 1327988007075 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1327988007076 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1327988007077 dimer interface [polypeptide binding]; other site 1327988007078 FMN binding site [chemical binding]; other site 1327988007079 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1327988007080 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1327988007081 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1327988007082 active site turn [active] 1327988007083 phosphorylation site [posttranslational modification] 1327988007084 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1327988007085 HPr interaction site; other site 1327988007086 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1327988007087 active site 1327988007088 phosphorylation site [posttranslational modification] 1327988007089 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1327988007090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988007091 Walker A/P-loop; other site 1327988007092 ATP binding site [chemical binding]; other site 1327988007093 Q-loop/lid; other site 1327988007094 ABC transporter signature motif; other site 1327988007095 Walker B; other site 1327988007096 D-loop; other site 1327988007097 H-loop/switch region; other site 1327988007098 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1327988007099 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1327988007100 TM-ABC transporter signature motif; other site 1327988007101 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1327988007102 zinc binding site [ion binding]; other site 1327988007103 putative ligand binding site [chemical binding]; other site 1327988007104 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1327988007105 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1327988007106 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1327988007107 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1327988007108 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1327988007109 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1327988007110 Walker A/P-loop; other site 1327988007111 ATP binding site [chemical binding]; other site 1327988007112 Q-loop/lid; other site 1327988007113 ABC transporter signature motif; other site 1327988007114 Walker B; other site 1327988007115 D-loop; other site 1327988007116 H-loop/switch region; other site 1327988007117 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1327988007118 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1327988007119 Walker A/P-loop; other site 1327988007120 ATP binding site [chemical binding]; other site 1327988007121 Q-loop/lid; other site 1327988007122 ABC transporter signature motif; other site 1327988007123 Walker B; other site 1327988007124 D-loop; other site 1327988007125 H-loop/switch region; other site 1327988007126 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1327988007127 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1327988007128 TM-ABC transporter signature motif; other site 1327988007129 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1327988007130 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1327988007131 TM-ABC transporter signature motif; other site 1327988007132 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1327988007133 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1327988007134 putative ligand binding site [chemical binding]; other site 1327988007135 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 1327988007136 active site 1327988007137 Predicted membrane protein [Function unknown]; Region: COG2246 1327988007138 GtrA-like protein; Region: GtrA; pfam04138 1327988007139 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1327988007140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988007141 non-specific DNA binding site [nucleotide binding]; other site 1327988007142 salt bridge; other site 1327988007143 sequence-specific DNA binding site [nucleotide binding]; other site 1327988007144 manganese transport protein MntH; Reviewed; Region: PRK00701 1327988007145 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1327988007146 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1327988007147 Ligand Binding Site [chemical binding]; other site 1327988007148 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1327988007149 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1327988007150 dimerization interface [polypeptide binding]; other site 1327988007151 putative DNA binding site [nucleotide binding]; other site 1327988007152 putative Zn2+ binding site [ion binding]; other site 1327988007153 Cadmium resistance transporter; Region: Cad; pfam03596 1327988007154 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1327988007155 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1327988007156 Walker A/P-loop; other site 1327988007157 ATP binding site [chemical binding]; other site 1327988007158 Q-loop/lid; other site 1327988007159 ABC transporter signature motif; other site 1327988007160 Walker B; other site 1327988007161 D-loop; other site 1327988007162 H-loop/switch region; other site 1327988007163 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1327988007164 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1327988007165 FtsX-like permease family; Region: FtsX; pfam02687 1327988007166 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1327988007167 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1327988007168 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1327988007169 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1327988007170 active site 1327988007171 metal binding site [ion binding]; metal-binding site 1327988007172 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1327988007173 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988007174 non-specific DNA binding site [nucleotide binding]; other site 1327988007175 salt bridge; other site 1327988007176 sequence-specific DNA binding site [nucleotide binding]; other site 1327988007177 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1327988007178 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1327988007179 HPr interaction site; other site 1327988007180 active site 1327988007181 phosphorylation site [posttranslational modification] 1327988007182 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1327988007183 active site 1327988007184 P-loop; other site 1327988007185 phosphorylation site [posttranslational modification] 1327988007186 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1327988007187 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1327988007188 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1327988007189 beta-galactosidase; Region: BGL; TIGR03356 1327988007190 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 1327988007191 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1327988007192 NADP binding site [chemical binding]; other site 1327988007193 putative substrate binding site [chemical binding]; other site 1327988007194 active site 1327988007195 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1327988007196 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1327988007197 DNA binding residues [nucleotide binding] 1327988007198 putative dimer interface [polypeptide binding]; other site 1327988007199 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1327988007200 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1327988007201 catalytic residue [active] 1327988007202 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1327988007203 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1327988007204 SdpI/YhfL protein family; Region: SdpI; pfam13630 1327988007205 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 1327988007206 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 1327988007207 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1327988007208 metal binding site [ion binding]; metal-binding site 1327988007209 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1327988007210 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1327988007211 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1327988007212 metal binding site [ion binding]; metal-binding site 1327988007213 active site 1327988007214 I-site; other site 1327988007215 DNA polymerase IV; Reviewed; Region: PRK03103 1327988007216 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1327988007217 active site 1327988007218 DNA binding site [nucleotide binding] 1327988007219 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1327988007220 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1327988007221 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1327988007222 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1327988007223 Walker A/P-loop; other site 1327988007224 ATP binding site [chemical binding]; other site 1327988007225 Q-loop/lid; other site 1327988007226 ABC transporter signature motif; other site 1327988007227 Walker B; other site 1327988007228 D-loop; other site 1327988007229 H-loop/switch region; other site 1327988007230 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1327988007231 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1327988007232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988007233 Walker A/P-loop; other site 1327988007234 ATP binding site [chemical binding]; other site 1327988007235 Q-loop/lid; other site 1327988007236 ABC transporter signature motif; other site 1327988007237 Walker B; other site 1327988007238 D-loop; other site 1327988007239 H-loop/switch region; other site 1327988007240 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1327988007241 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1327988007242 metal binding site [ion binding]; metal-binding site 1327988007243 dimer interface [polypeptide binding]; other site 1327988007244 oxidoreductase; Provisional; Region: PRK06128 1327988007245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1327988007246 NAD(P) binding site [chemical binding]; other site 1327988007247 active site 1327988007248 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1327988007249 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1327988007250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988007251 non-specific DNA binding site [nucleotide binding]; other site 1327988007252 salt bridge; other site 1327988007253 sequence-specific DNA binding site [nucleotide binding]; other site 1327988007254 inner membrane transporter YjeM; Provisional; Region: PRK15238 1327988007255 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1327988007256 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1327988007257 dimer interface [polypeptide binding]; other site 1327988007258 active site 1327988007259 metal binding site [ion binding]; metal-binding site 1327988007260 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1327988007261 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 1327988007262 catalytic Zn binding site [ion binding]; other site 1327988007263 NAD binding site [chemical binding]; other site 1327988007264 structural Zn binding site [ion binding]; other site 1327988007265 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1327988007266 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1327988007267 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1327988007268 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1327988007269 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1327988007270 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1327988007271 MucBP domain; Region: MucBP; pfam06458 1327988007272 Helix-turn-helix domain; Region: HTH_18; pfam12833 1327988007273 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1327988007274 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1327988007275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1327988007276 ATP binding site [chemical binding]; other site 1327988007277 Mg2+ binding site [ion binding]; other site 1327988007278 G-X-G motif; other site 1327988007279 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1327988007280 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1327988007281 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1327988007282 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1327988007283 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1327988007284 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 1327988007285 NAD(P) binding site [chemical binding]; other site 1327988007286 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1327988007287 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1327988007288 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1327988007289 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1327988007290 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1327988007291 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1327988007292 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1327988007293 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1327988007294 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1327988007295 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1327988007296 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1327988007297 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1327988007298 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1327988007299 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1327988007300 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1327988007301 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988007302 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1327988007303 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988007304 motif II; other site 1327988007305 Predicted transcriptional regulators [Transcription]; Region: COG1733 1327988007306 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1327988007307 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1327988007308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988007309 putative substrate translocation pore; other site 1327988007310 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1327988007311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1327988007312 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1327988007313 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1327988007314 active site 1327988007315 dimer interface [polypeptide binding]; other site 1327988007316 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1327988007317 Ligand Binding Site [chemical binding]; other site 1327988007318 Molecular Tunnel; other site 1327988007319 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1327988007320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1327988007321 active site 1327988007322 phosphorylation site [posttranslational modification] 1327988007323 intermolecular recognition site; other site 1327988007324 dimerization interface [polypeptide binding]; other site 1327988007325 LytTr DNA-binding domain; Region: LytTR; pfam04397 1327988007326 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1327988007327 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988007328 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988007329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1327988007330 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1327988007331 NAD(P) binding site [chemical binding]; other site 1327988007332 active site 1327988007333 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1327988007334 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1327988007335 NAD(P) binding site [chemical binding]; other site 1327988007336 catalytic residues [active] 1327988007337 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1327988007338 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 1327988007339 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1327988007340 active site 1327988007341 Bacterial SH3 domain; Region: SH3_5; pfam08460 1327988007342 Bacterial SH3 domain; Region: SH3_5; pfam08460 1327988007343 Bacterial SH3 domain; Region: SH3_5; pfam08460 1327988007344 Bacterial SH3 domain; Region: SH3_5; pfam08460 1327988007345 Bacterial SH3 domain; Region: SH3_5; pfam08460 1327988007346 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1327988007347 Predicted transcriptional regulators [Transcription]; Region: COG1733 1327988007348 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1327988007349 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1327988007350 classical (c) SDRs; Region: SDR_c; cd05233 1327988007351 NAD(P) binding site [chemical binding]; other site 1327988007352 active site 1327988007353 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988007354 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988007355 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 1327988007356 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1327988007357 NADP binding site [chemical binding]; other site 1327988007358 putative substrate binding site [chemical binding]; other site 1327988007359 active site 1327988007360 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1327988007361 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1327988007362 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1327988007363 active site 1327988007364 catalytic tetrad [active] 1327988007365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988007366 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988007367 putative substrate translocation pore; other site 1327988007368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988007369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988007370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988007371 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1327988007372 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1327988007373 intersubunit interface [polypeptide binding]; other site 1327988007374 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1327988007375 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1327988007376 Walker A/P-loop; other site 1327988007377 ATP binding site [chemical binding]; other site 1327988007378 Q-loop/lid; other site 1327988007379 ABC transporter signature motif; other site 1327988007380 Walker B; other site 1327988007381 D-loop; other site 1327988007382 H-loop/switch region; other site 1327988007383 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1327988007384 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1327988007385 ABC-ATPase subunit interface; other site 1327988007386 dimer interface [polypeptide binding]; other site 1327988007387 putative PBP binding regions; other site 1327988007388 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1327988007389 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1327988007390 ABC-ATPase subunit interface; other site 1327988007391 dimer interface [polypeptide binding]; other site 1327988007392 putative PBP binding regions; other site 1327988007393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988007394 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1327988007395 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1327988007396 putative NAD(P) binding site [chemical binding]; other site 1327988007397 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1327988007398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1327988007399 NAD(P) binding site [chemical binding]; other site 1327988007400 active site 1327988007401 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1327988007402 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1327988007403 putative trimer interface [polypeptide binding]; other site 1327988007404 putative CoA binding site [chemical binding]; other site 1327988007405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1327988007406 NAD(P) binding site [chemical binding]; other site 1327988007407 active site 1327988007408 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1327988007409 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1327988007410 DNA binding residues [nucleotide binding] 1327988007411 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1327988007412 MucBP domain; Region: MucBP; pfam06458 1327988007413 MucBP domain; Region: MucBP; pfam06458 1327988007414 MucBP domain; Region: MucBP; pfam06458 1327988007415 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1327988007416 MucBP domain; Region: MucBP; pfam06458 1327988007417 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1327988007418 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1327988007419 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1327988007420 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1327988007421 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1327988007422 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1327988007423 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1327988007424 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1327988007425 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1327988007426 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1327988007427 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1327988007428 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1327988007429 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1327988007430 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1327988007431 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988007432 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988007433 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988007434 GTP-binding protein LepA; Provisional; Region: PRK05433 1327988007435 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1327988007436 G1 box; other site 1327988007437 putative GEF interaction site [polypeptide binding]; other site 1327988007438 GTP/Mg2+ binding site [chemical binding]; other site 1327988007439 Switch I region; other site 1327988007440 G2 box; other site 1327988007441 G3 box; other site 1327988007442 Switch II region; other site 1327988007443 G4 box; other site 1327988007444 G5 box; other site 1327988007445 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1327988007446 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1327988007447 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1327988007448 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1327988007449 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1327988007450 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1327988007451 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1327988007452 putative NADH binding site [chemical binding]; other site 1327988007453 putative active site [active] 1327988007454 nudix motif; other site 1327988007455 putative metal binding site [ion binding]; other site 1327988007456 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988007457 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1327988007458 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1327988007459 dimerization interface [polypeptide binding]; other site 1327988007460 hypothetical protein; Validated; Region: PRK07121 1327988007461 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1327988007462 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1327988007463 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988007464 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988007465 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988007466 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988007467 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1327988007468 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1327988007469 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1327988007470 dimerization interface [polypeptide binding]; other site 1327988007471 DPS ferroxidase diiron center [ion binding]; other site 1327988007472 ion pore; other site 1327988007473 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1327988007474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1327988007475 DNA-binding site [nucleotide binding]; DNA binding site 1327988007476 UTRA domain; Region: UTRA; pfam07702 1327988007477 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1327988007478 beta-galactosidase; Region: BGL; TIGR03356 1327988007479 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1327988007480 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1327988007481 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1327988007482 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1327988007483 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1327988007484 DNA binding residues [nucleotide binding] 1327988007485 putative dimer interface [polypeptide binding]; other site 1327988007486 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1327988007487 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1327988007488 Double zinc ribbon; Region: DZR; pfam12773 1327988007489 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1327988007490 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1327988007491 Protein of unknown function (DUF3781); Region: DUF3781; pfam12636 1327988007492 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1327988007493 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1327988007494 conserved cys residue [active] 1327988007495 Predicted transcriptional regulators [Transcription]; Region: COG1733 1327988007496 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1327988007497 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1327988007498 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1327988007499 Walker A/P-loop; other site 1327988007500 ATP binding site [chemical binding]; other site 1327988007501 Q-loop/lid; other site 1327988007502 ABC transporter signature motif; other site 1327988007503 Walker B; other site 1327988007504 D-loop; other site 1327988007505 H-loop/switch region; other site 1327988007506 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1327988007507 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988007508 non-specific DNA binding site [nucleotide binding]; other site 1327988007509 salt bridge; other site 1327988007510 sequence-specific DNA binding site [nucleotide binding]; other site 1327988007511 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1327988007512 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1327988007513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988007514 non-specific DNA binding site [nucleotide binding]; other site 1327988007515 salt bridge; other site 1327988007516 sequence-specific DNA binding site [nucleotide binding]; other site 1327988007517 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1327988007518 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1327988007519 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1327988007520 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1327988007521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988007522 Walker A/P-loop; other site 1327988007523 ATP binding site [chemical binding]; other site 1327988007524 Q-loop/lid; other site 1327988007525 ABC transporter signature motif; other site 1327988007526 Walker B; other site 1327988007527 D-loop; other site 1327988007528 H-loop/switch region; other site 1327988007529 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1327988007530 catalytic core [active] 1327988007531 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1327988007532 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1327988007533 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1327988007534 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1327988007535 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1327988007536 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1327988007537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1327988007538 S-adenosylmethionine binding site [chemical binding]; other site 1327988007539 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1327988007540 active site 1327988007541 ATP binding site [chemical binding]; other site 1327988007542 substrate binding site [chemical binding]; other site 1327988007543 activation loop (A-loop); other site 1327988007544 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1327988007545 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1327988007546 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1327988007547 AzlC protein; Region: AzlC; pfam03591 1327988007548 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1327988007549 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1327988007550 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1327988007551 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1327988007552 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1327988007553 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1327988007554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1327988007555 dimer interface [polypeptide binding]; other site 1327988007556 phosphorylation site [posttranslational modification] 1327988007557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1327988007558 ATP binding site [chemical binding]; other site 1327988007559 Mg2+ binding site [ion binding]; other site 1327988007560 G-X-G motif; other site 1327988007561 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1327988007562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1327988007563 active site 1327988007564 phosphorylation site [posttranslational modification] 1327988007565 intermolecular recognition site; other site 1327988007566 dimerization interface [polypeptide binding]; other site 1327988007567 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1327988007568 DNA binding site [nucleotide binding] 1327988007569 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1327988007570 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1327988007571 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1327988007572 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 1327988007573 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1327988007574 active site 1327988007575 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 1327988007576 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1327988007577 GTP-binding protein YchF; Reviewed; Region: PRK09601 1327988007578 YchF GTPase; Region: YchF; cd01900 1327988007579 G1 box; other site 1327988007580 GTP/Mg2+ binding site [chemical binding]; other site 1327988007581 Switch I region; other site 1327988007582 G2 box; other site 1327988007583 Switch II region; other site 1327988007584 G3 box; other site 1327988007585 G4 box; other site 1327988007586 G5 box; other site 1327988007587 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1327988007588 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1327988007589 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1327988007590 ParB-like nuclease domain; Region: ParB; smart00470 1327988007591 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 1327988007592 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1327988007593 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1327988007594 P-loop; other site 1327988007595 Magnesium ion binding site [ion binding]; other site 1327988007596 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1327988007597 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1327988007598 ParB-like nuclease domain; Region: ParBc; pfam02195 1327988007599 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1327988007600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1327988007601 S-adenosylmethionine binding site [chemical binding]; other site 1327988007602 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1327988007603 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1327988007604 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1327988007605 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1327988007606 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1327988007607 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988007608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1327988007609 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1327988007610 dimerization interface [polypeptide binding]; other site 1327988007611 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1327988007612 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1327988007613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988007614 homodimer interface [polypeptide binding]; other site 1327988007615 catalytic residue [active] 1327988007616 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1327988007617 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1327988007618 substrate binding pocket [chemical binding]; other site 1327988007619 membrane-bound complex binding site; other site 1327988007620 hinge residues; other site 1327988007621 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1327988007622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988007623 dimer interface [polypeptide binding]; other site 1327988007624 conserved gate region; other site 1327988007625 putative PBP binding loops; other site 1327988007626 ABC-ATPase subunit interface; other site 1327988007627 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1327988007628 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1327988007629 Walker A/P-loop; other site 1327988007630 ATP binding site [chemical binding]; other site 1327988007631 Q-loop/lid; other site 1327988007632 ABC transporter signature motif; other site 1327988007633 Walker B; other site 1327988007634 D-loop; other site 1327988007635 H-loop/switch region; other site 1327988007636 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1327988007637 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1327988007638 substrate binding pocket [chemical binding]; other site 1327988007639 membrane-bound complex binding site; other site 1327988007640 hinge residues; other site 1327988007641 Predicted transcriptional regulators [Transcription]; Region: COG1695 1327988007642 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1327988007643 Predicted membrane protein [Function unknown]; Region: COG4709 1327988007644 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1327988007645 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1327988007646 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1327988007647 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1327988007648 active site turn [active] 1327988007649 phosphorylation site [posttranslational modification] 1327988007650 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1327988007651 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1327988007652 HPr interaction site; other site 1327988007653 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1327988007654 active site 1327988007655 phosphorylation site [posttranslational modification] 1327988007656 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1327988007657 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1327988007658 Ca binding site [ion binding]; other site 1327988007659 active site 1327988007660 catalytic site [active] 1327988007661 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1327988007662 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1327988007663 DNA binding site [nucleotide binding] 1327988007664 domain linker motif; other site 1327988007665 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1327988007666 putative dimerization interface [polypeptide binding]; other site 1327988007667 putative ligand binding site [chemical binding]; other site 1327988007668 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1327988007669 putative active site [active] 1327988007670 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1327988007671 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1327988007672 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1327988007673 Walker A/P-loop; other site 1327988007674 ATP binding site [chemical binding]; other site 1327988007675 Q-loop/lid; other site 1327988007676 ABC transporter signature motif; other site 1327988007677 Walker B; other site 1327988007678 D-loop; other site 1327988007679 H-loop/switch region; other site 1327988007680 TRAM domain; Region: TRAM; cl01282 1327988007681 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1327988007682 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1327988007683 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1327988007684 NADP binding site [chemical binding]; other site 1327988007685 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988007686 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1327988007687 active site 1327988007688 motif I; other site 1327988007689 motif II; other site 1327988007690 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988007691 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1327988007692 ROK family; Region: ROK; pfam00480 1327988007693 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1327988007694 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 1327988007695 active site 1327988007696 metal binding site [ion binding]; metal-binding site 1327988007697 catalytic site [active] 1327988007698 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 1327988007699 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1327988007700 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1327988007701 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1327988007702 active site 1327988007703 P-loop; other site 1327988007704 phosphorylation site [posttranslational modification] 1327988007705 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1327988007706 active site 1327988007707 phosphorylation site [posttranslational modification] 1327988007708 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1327988007709 HTH domain; Region: HTH_11; pfam08279 1327988007710 PRD domain; Region: PRD; pfam00874 1327988007711 PRD domain; Region: PRD; pfam00874 1327988007712 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1327988007713 active site 1327988007714 P-loop; other site 1327988007715 phosphorylation site [posttranslational modification] 1327988007716 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1327988007717 active site 1327988007718 phosphorylation site [posttranslational modification] 1327988007719 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1327988007720 DNA binding residues [nucleotide binding] 1327988007721 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1327988007722 putative dimer interface [polypeptide binding]; other site 1327988007723 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1327988007724 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1327988007725 NADP binding site [chemical binding]; other site 1327988007726 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1327988007727 HPr interaction site; other site 1327988007728 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1327988007729 active site 1327988007730 phosphorylation site [posttranslational modification] 1327988007731 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1327988007732 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1327988007733 active site turn [active] 1327988007734 phosphorylation site [posttranslational modification] 1327988007735 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1327988007736 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1327988007737 endonuclease III; Region: ENDO3c; smart00478 1327988007738 minor groove reading motif; other site 1327988007739 helix-hairpin-helix signature motif; other site 1327988007740 substrate binding pocket [chemical binding]; other site 1327988007741 active site 1327988007742 Predicted flavoprotein [General function prediction only]; Region: COG0431 1327988007743 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1327988007744 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1327988007745 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1327988007746 metal binding site 2 [ion binding]; metal-binding site 1327988007747 putative DNA binding helix; other site 1327988007748 metal binding site 1 [ion binding]; metal-binding site 1327988007749 dimer interface [polypeptide binding]; other site 1327988007750 structural Zn2+ binding site [ion binding]; other site 1327988007751 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1327988007752 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1327988007753 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1327988007754 active site 1327988007755 metal binding site [ion binding]; metal-binding site 1327988007756 hexamer interface [polypeptide binding]; other site 1327988007757 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1327988007758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1327988007759 Coenzyme A binding pocket [chemical binding]; other site 1327988007760 LrgA family; Region: LrgA; pfam03788 1327988007761 LrgB-like family; Region: LrgB; pfam04172 1327988007762 EDD domain protein, DegV family; Region: DegV; TIGR00762 1327988007763 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1327988007764 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 1327988007765 phytoene desaturase; Region: crtI_fam; TIGR02734 1327988007766 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1327988007767 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1327988007768 active site lid residues [active] 1327988007769 substrate binding pocket [chemical binding]; other site 1327988007770 catalytic residues [active] 1327988007771 substrate-Mg2+ binding site; other site 1327988007772 aspartate-rich region 1; other site 1327988007773 aspartate-rich region 2; other site 1327988007774 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1327988007775 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1327988007776 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1327988007777 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1327988007778 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1327988007779 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1327988007780 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1327988007781 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1327988007782 adenylosuccinate lyase; Provisional; Region: PRK07492 1327988007783 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1327988007784 tetramer interface [polypeptide binding]; other site 1327988007785 active site 1327988007786 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1327988007787 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1327988007788 GDP-binding site [chemical binding]; other site 1327988007789 ACT binding site; other site 1327988007790 IMP binding site; other site 1327988007791 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1327988007792 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1327988007793 active site 1327988007794 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1327988007795 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1327988007796 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1327988007797 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1327988007798 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1327988007799 putative active site [active] 1327988007800 catalytic site [active] 1327988007801 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1327988007802 putative active site [active] 1327988007803 catalytic site [active] 1327988007804 amino acid transporter; Region: 2A0306; TIGR00909 1327988007805 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1327988007806 K+ potassium transporter; Region: K_trans; pfam02705 1327988007807 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1327988007808 Cation efflux family; Region: Cation_efflux; pfam01545 1327988007809 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1327988007810 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1327988007811 substrate binding site [chemical binding]; other site 1327988007812 THF binding site; other site 1327988007813 zinc-binding site [ion binding]; other site 1327988007814 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1327988007815 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1327988007816 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1327988007817 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1327988007818 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1327988007819 dimerization interface [polypeptide binding]; other site 1327988007820 putative DNA binding site [nucleotide binding]; other site 1327988007821 putative Zn2+ binding site [ion binding]; other site 1327988007822 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1327988007823 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1327988007824 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1327988007825 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1327988007826 dihydropteroate synthase; Region: DHPS; TIGR01496 1327988007827 substrate binding pocket [chemical binding]; other site 1327988007828 dimer interface [polypeptide binding]; other site 1327988007829 inhibitor binding site; inhibition site 1327988007830 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1327988007831 active site 1327988007832 dimerization interface [polypeptide binding]; other site 1327988007833 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1327988007834 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1327988007835 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1327988007836 GTP cyclohydrolase I; Provisional; Region: PLN03044 1327988007837 active site 1327988007838 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1327988007839 catalytic center binding site [active] 1327988007840 ATP binding site [chemical binding]; other site 1327988007841 Dihydroneopterin aldolase; Region: FolB; pfam02152 1327988007842 active site 1327988007843 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1327988007844 Colicin V production protein; Region: Colicin_V; pfam02674 1327988007845 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 1327988007846 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1327988007847 metal binding site [ion binding]; metal-binding site 1327988007848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988007849 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988007850 putative substrate translocation pore; other site 1327988007851 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1327988007852 Beta-lactamase; Region: Beta-lactamase; pfam00144 1327988007853 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1327988007854 Pyruvate formate lyase 1; Region: PFL1; cd01678 1327988007855 coenzyme A binding site [chemical binding]; other site 1327988007856 active site 1327988007857 catalytic residues [active] 1327988007858 glycine loop; other site 1327988007859 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1327988007860 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1327988007861 FeS/SAM binding site; other site 1327988007862 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1327988007863 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1327988007864 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1327988007865 active site 1327988007866 catalytic tetrad [active] 1327988007867 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1327988007868 nucleotide binding site/active site [active] 1327988007869 HIT family signature motif; other site 1327988007870 catalytic residue [active] 1327988007871 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1327988007872 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1327988007873 active site 1327988007874 catalytic triad [active] 1327988007875 oxyanion hole [active] 1327988007876 BCCT family transporter; Region: BCCT; pfam02028 1327988007877 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1327988007878 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1327988007879 Protein of unknown function (DUF419); Region: DUF419; cl15265 1327988007880 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 1327988007881 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1327988007882 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1327988007883 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1327988007884 active site 1327988007885 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1327988007886 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1327988007887 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1327988007888 dimer interface [polypeptide binding]; other site 1327988007889 active site 1327988007890 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1327988007891 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1327988007892 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1327988007893 Spore germination protein; Region: Spore_permease; cl17796 1327988007894 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1327988007895 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1327988007896 tetramer interfaces [polypeptide binding]; other site 1327988007897 binuclear metal-binding site [ion binding]; other site 1327988007898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1327988007899 NmrA-like family; Region: NmrA; pfam05368 1327988007900 NAD(P) binding site [chemical binding]; other site 1327988007901 active site 1327988007902 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1327988007903 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1327988007904 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1327988007905 ArsC family; Region: ArsC; pfam03960 1327988007906 putative catalytic residues [active] 1327988007907 thiol/disulfide switch; other site 1327988007908 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1327988007909 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1327988007910 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1327988007911 minor groove reading motif; other site 1327988007912 helix-hairpin-helix signature motif; other site 1327988007913 substrate binding pocket [chemical binding]; other site 1327988007914 active site 1327988007915 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1327988007916 DNA binding and oxoG recognition site [nucleotide binding] 1327988007917 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1327988007918 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1327988007919 putative dimer interface [polypeptide binding]; other site 1327988007920 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 1327988007921 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1327988007922 putative NAD(P) binding site [chemical binding]; other site 1327988007923 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1327988007924 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1327988007925 Coenzyme A binding pocket [chemical binding]; other site 1327988007926 EamA-like transporter family; Region: EamA; pfam00892 1327988007927 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1327988007928 EamA-like transporter family; Region: EamA; pfam00892 1327988007929 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1327988007930 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1327988007931 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1327988007932 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1327988007933 active site 1327988007934 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1327988007935 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1327988007936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988007937 motif II; other site 1327988007938 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1327988007939 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1327988007940 zinc-finger; Region: zf-RING_3; pfam14369 1327988007941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988007942 putative substrate translocation pore; other site 1327988007943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988007944 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1327988007945 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1327988007946 Na binding site [ion binding]; other site 1327988007947 drug efflux system protein MdtG; Provisional; Region: PRK09874 1327988007948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988007949 putative substrate translocation pore; other site 1327988007950 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1327988007951 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1327988007952 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1327988007953 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1327988007954 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1327988007955 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1327988007956 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1327988007957 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1327988007958 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988007959 active site 1327988007960 motif I; other site 1327988007961 motif II; other site 1327988007962 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1327988007963 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1327988007964 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1327988007965 active site 1327988007966 metal binding site [ion binding]; metal-binding site 1327988007967 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1327988007968 Membrane transport protein; Region: Mem_trans; cl09117 1327988007969 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1327988007970 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1327988007971 active site 1327988007972 catalytic tetrad [active] 1327988007973 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1327988007974 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1327988007975 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1327988007976 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1327988007977 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1327988007978 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1327988007979 putative ADP-ribose binding site [chemical binding]; other site 1327988007980 putative active site [active] 1327988007981 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988007982 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988007983 Predicted secreted protein [Function unknown]; Region: COG4086 1327988007984 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1327988007985 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1327988007986 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1327988007987 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1327988007988 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1327988007989 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1327988007990 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1327988007991 MarR family; Region: MarR_2; pfam12802 1327988007992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988007993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988007994 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1327988007995 active site 1327988007996 nucleotide-binding site [chemical binding]; other site 1327988007997 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1327988007998 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 1327988007999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988008000 catalytic residue [active] 1327988008001 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1327988008002 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1327988008003 NlpC/P60 family; Region: NLPC_P60; pfam00877 1327988008004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988008005 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1327988008006 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1327988008007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1327988008008 S-adenosylmethionine binding site [chemical binding]; other site 1327988008009 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1327988008010 putative active site [active] 1327988008011 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 1327988008012 active site 1327988008013 catalytic triad [active] 1327988008014 oxyanion hole [active] 1327988008015 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1327988008016 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1327988008017 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1327988008018 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1327988008019 amphipathic channel; other site 1327988008020 Asn-Pro-Ala signature motifs; other site 1327988008021 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1327988008022 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1327988008023 catalytic residues [active] 1327988008024 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1327988008025 putative homodimer interface [polypeptide binding]; other site 1327988008026 putative homotetramer interface [polypeptide binding]; other site 1327988008027 putative metal binding site [ion binding]; other site 1327988008028 putative homodimer-homodimer interface [polypeptide binding]; other site 1327988008029 putative allosteric switch controlling residues; other site 1327988008030 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1327988008031 Ferritin-like domain; Region: Ferritin; pfam00210 1327988008032 dimerization interface [polypeptide binding]; other site 1327988008033 DPS ferroxidase diiron center [ion binding]; other site 1327988008034 ion pore; other site 1327988008035 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1327988008036 metal-binding site [ion binding] 1327988008037 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1327988008038 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1327988008039 ligand binding site [chemical binding]; other site 1327988008040 flexible hinge region; other site 1327988008041 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1327988008042 non-specific DNA interactions [nucleotide binding]; other site 1327988008043 DNA binding site [nucleotide binding] 1327988008044 sequence specific DNA binding site [nucleotide binding]; other site 1327988008045 putative cAMP binding site [chemical binding]; other site 1327988008046 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1327988008047 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1327988008048 active site 1327988008049 Zn binding site [ion binding]; other site 1327988008050 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1327988008051 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1327988008052 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1327988008053 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1327988008054 legume lectins; Region: lectin_L-type; cl14058 1327988008055 homotetramer interaction site [polypeptide binding]; other site 1327988008056 carbohydrate binding site [chemical binding]; other site 1327988008057 metal binding site [ion binding]; metal-binding site 1327988008058 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1327988008059 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1327988008060 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1327988008061 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1327988008062 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1327988008063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988008064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988008065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 1327988008066 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1327988008067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988008068 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1327988008069 Walker A motif; other site 1327988008070 ATP binding site [chemical binding]; other site 1327988008071 Walker B motif; other site 1327988008072 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1327988008073 amphipathic channel; other site 1327988008074 Asn-Pro-Ala signature motifs; other site 1327988008075 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1327988008076 ABC1 family; Region: ABC1; cl17513 1327988008077 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1327988008078 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1327988008079 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988008080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988008081 putative substrate translocation pore; other site 1327988008082 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1327988008083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988008084 putative substrate translocation pore; other site 1327988008085 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988008086 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1327988008087 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1327988008088 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1327988008089 Fic/DOC family; Region: Fic; cl00960 1327988008090 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988008091 non-specific DNA binding site [nucleotide binding]; other site 1327988008092 salt bridge; other site 1327988008093 sequence-specific DNA binding site [nucleotide binding]; other site 1327988008094 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1327988008095 FIC domain binding interface [polypeptide binding]; other site 1327988008096 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1327988008097 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1327988008098 DNA binding site [nucleotide binding] 1327988008099 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1327988008100 putative dimerization interface [polypeptide binding]; other site 1327988008101 putative ligand binding site [chemical binding]; other site 1327988008102 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1327988008103 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1327988008104 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1327988008105 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1327988008106 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1327988008107 NAD binding site [chemical binding]; other site 1327988008108 homodimer interface [polypeptide binding]; other site 1327988008109 active site 1327988008110 substrate binding site [chemical binding]; other site 1327988008111 galactokinase; Provisional; Region: PRK05322 1327988008112 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1327988008113 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1327988008114 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1327988008115 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1327988008116 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1327988008117 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1327988008118 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1327988008119 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1327988008120 Melibiase; Region: Melibiase; pfam02065 1327988008121 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1327988008122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988008123 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1327988008124 HPr interaction site; other site 1327988008125 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1327988008126 active site 1327988008127 phosphorylation site [posttranslational modification] 1327988008128 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1327988008129 active site 1327988008130 catalytic residues [active] 1327988008131 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1327988008132 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1327988008133 DNA binding site [nucleotide binding] 1327988008134 domain linker motif; other site 1327988008135 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1327988008136 putative dimerization interface [polypeptide binding]; other site 1327988008137 putative ligand binding site [chemical binding]; other site 1327988008138 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1327988008139 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1327988008140 active site 1327988008141 catalytic tetrad [active] 1327988008142 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1327988008143 FMN-binding domain; Region: FMN_bind; cl01081 1327988008144 L-aspartate oxidase; Provisional; Region: PRK06175 1327988008145 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1327988008146 Predicted flavoprotein [General function prediction only]; Region: COG0431 1327988008147 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1327988008148 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1327988008149 ApbE family; Region: ApbE; pfam02424 1327988008150 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1327988008151 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1327988008152 active site 1327988008153 catalytic residue [active] 1327988008154 dimer interface [polypeptide binding]; other site 1327988008155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988008156 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988008157 putative substrate translocation pore; other site 1327988008158 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1327988008159 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1327988008160 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1327988008161 shikimate binding site; other site 1327988008162 NAD(P) binding site [chemical binding]; other site 1327988008163 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1327988008164 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1327988008165 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1327988008166 putative dimerization interface [polypeptide binding]; other site 1327988008167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988008168 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988008169 putative substrate translocation pore; other site 1327988008170 Putative esterase; Region: Esterase; pfam00756 1327988008171 S-formylglutathione hydrolase; Region: PLN02442 1327988008172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1327988008173 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1327988008174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1327988008175 DNA-binding site [nucleotide binding]; DNA binding site 1327988008176 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1327988008177 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1327988008178 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1327988008179 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570 1327988008180 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1327988008181 putative active site [active] 1327988008182 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1327988008183 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1327988008184 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1327988008185 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1327988008186 beta-galactosidase; Region: BGL; TIGR03356 1327988008187 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1327988008188 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1327988008189 active site turn [active] 1327988008190 phosphorylation site [posttranslational modification] 1327988008191 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1327988008192 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1327988008193 HPr interaction site; other site 1327988008194 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1327988008195 active site 1327988008196 phosphorylation site [posttranslational modification] 1327988008197 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1327988008198 CAT RNA binding domain; Region: CAT_RBD; smart01061 1327988008199 PRD domain; Region: PRD; pfam00874 1327988008200 PRD domain; Region: PRD; pfam00874 1327988008201 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1327988008202 beta-galactosidase; Region: BGL; TIGR03356 1327988008203 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1327988008204 beta-galactosidase; Region: BGL; TIGR03356 1327988008205 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1327988008206 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1327988008207 active site turn [active] 1327988008208 phosphorylation site [posttranslational modification] 1327988008209 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1327988008210 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1327988008211 HPr interaction site; other site 1327988008212 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1327988008213 active site 1327988008214 phosphorylation site [posttranslational modification] 1327988008215 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1327988008216 CAT RNA binding domain; Region: CAT_RBD; smart01061 1327988008217 PRD domain; Region: PRD; pfam00874 1327988008218 PRD domain; Region: PRD; pfam00874 1327988008219 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1327988008220 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1327988008221 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1327988008222 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1327988008223 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1327988008224 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1327988008225 DNA binding site [nucleotide binding] 1327988008226 domain linker motif; other site 1327988008227 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1327988008228 dimerization interface [polypeptide binding]; other site 1327988008229 ligand binding site [chemical binding]; other site 1327988008230 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988008231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988008232 putative substrate translocation pore; other site 1327988008233 putative alpha-glucosidase; Provisional; Region: PRK10658 1327988008234 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1327988008235 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 1327988008236 trimer interface [polypeptide binding]; other site 1327988008237 active site 1327988008238 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 1327988008239 catalytic site [active] 1327988008240 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1327988008241 MULE transposase domain; Region: MULE; pfam10551 1327988008242 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1327988008243 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1327988008244 active site 1327988008245 sugar phosphate phosphatase; Provisional; Region: PRK10513 1327988008246 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988008247 active site 1327988008248 motif I; other site 1327988008249 motif II; other site 1327988008250 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1327988008251 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1327988008252 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1327988008253 TPP-binding site [chemical binding]; other site 1327988008254 dimer interface [polypeptide binding]; other site 1327988008255 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1327988008256 PYR/PP interface [polypeptide binding]; other site 1327988008257 dimer interface [polypeptide binding]; other site 1327988008258 TPP binding site [chemical binding]; other site 1327988008259 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1327988008260 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1327988008261 active site 1327988008262 intersubunit interactions; other site 1327988008263 catalytic residue [active] 1327988008264 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1327988008265 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1327988008266 active site 1327988008267 P-loop; other site 1327988008268 phosphorylation site [posttranslational modification] 1327988008269 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1327988008270 active site 1327988008271 phosphorylation site [posttranslational modification] 1327988008272 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1327988008273 PRD domain; Region: PRD; pfam00874 1327988008274 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1327988008275 active site 1327988008276 P-loop; other site 1327988008277 phosphorylation site [posttranslational modification] 1327988008278 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1327988008279 active site 1327988008280 phosphorylation site [posttranslational modification] 1327988008281 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1327988008282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1327988008283 motif II; other site 1327988008284 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1327988008285 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 1327988008286 putative NAD(P) binding site [chemical binding]; other site 1327988008287 catalytic Zn binding site [ion binding]; other site 1327988008288 structural Zn binding site [ion binding]; other site 1327988008289 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1327988008290 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1327988008291 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1327988008292 active site 1327988008293 P-loop; other site 1327988008294 phosphorylation site [posttranslational modification] 1327988008295 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1327988008296 active site 1327988008297 phosphorylation site [posttranslational modification] 1327988008298 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1327988008299 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1327988008300 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1327988008301 putative phosphoketolase; Provisional; Region: PRK05261 1327988008302 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1327988008303 TPP-binding site; other site 1327988008304 XFP C-terminal domain; Region: XFP_C; pfam09363 1327988008305 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1327988008306 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1327988008307 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1327988008308 putative active site [active] 1327988008309 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1327988008310 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1327988008311 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1327988008312 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1327988008313 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1327988008314 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1327988008315 Na binding site [ion binding]; other site 1327988008316 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1327988008317 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1327988008318 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1327988008319 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1327988008320 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1327988008321 nucleotide binding site [chemical binding]; other site 1327988008322 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1327988008323 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1327988008324 inhibitor site; inhibition site 1327988008325 active site 1327988008326 dimer interface [polypeptide binding]; other site 1327988008327 catalytic residue [active] 1327988008328 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1327988008329 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1327988008330 putative active site cavity [active] 1327988008331 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1327988008332 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1327988008333 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1327988008334 conserved hypothetical protein; Region: TIGR02328 1327988008335 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 1327988008336 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1327988008337 Predicted membrane protein [Function unknown]; Region: COG2261 1327988008338 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1327988008339 Catalases are antioxidant enzymes that catalyse the conversion of hydrogen peroxide to water and molecular oxygen, serving to protect cells from its toxic effects; Region: Catalase; smart01060 1327988008340 heme binding pocket [chemical binding]; other site 1327988008341 Catalase-related immune-responsive; Region: Catalase-rel; pfam06628 1327988008342 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988008343 Helix-turn-helix domain; Region: HTH_38; pfam13936 1327988008344 Integrase core domain; Region: rve; pfam00665 1327988008345 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1327988008346 ArsC family; Region: ArsC; pfam03960 1327988008347 putative catalytic residues [active] 1327988008348 thiol/disulfide switch; other site 1327988008349 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1327988008350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1327988008351 active site 1327988008352 phosphorylation site [posttranslational modification] 1327988008353 intermolecular recognition site; other site 1327988008354 dimerization interface [polypeptide binding]; other site 1327988008355 LytTr DNA-binding domain; Region: LytTR; pfam04397 1327988008356 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1327988008357 Staphylococcal AgrD protein; Region: AgrD; cl05477 1327988008358 Accessory gene regulator B; Region: AgrB; smart00793 1327988008359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988008360 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1327988008361 Walker A motif; other site 1327988008362 ATP binding site [chemical binding]; other site 1327988008363 Walker B motif; other site 1327988008364 arginine finger; other site 1327988008365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988008366 Walker A motif; other site 1327988008367 ATP binding site [chemical binding]; other site 1327988008368 Walker B motif; other site 1327988008369 arginine finger; other site 1327988008370 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1327988008371 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 1327988008372 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 1327988008373 teramer interface [polypeptide binding]; other site 1327988008374 active site 1327988008375 FMN binding site [chemical binding]; other site 1327988008376 catalytic residues [active] 1327988008377 pyruvate oxidase; Provisional; Region: PRK08611 1327988008378 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1327988008379 PYR/PP interface [polypeptide binding]; other site 1327988008380 dimer interface [polypeptide binding]; other site 1327988008381 tetramer interface [polypeptide binding]; other site 1327988008382 TPP binding site [chemical binding]; other site 1327988008383 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1327988008384 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1327988008385 TPP-binding site [chemical binding]; other site 1327988008386 Transcriptional regulator; Region: Rrf2; pfam02082 1327988008387 Rrf2 family protein; Region: rrf2_super; TIGR00738 1327988008388 Transcriptional regulator; Region: Rrf2; cl17282 1327988008389 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 1327988008390 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1327988008391 PYR/PP interface [polypeptide binding]; other site 1327988008392 dimer interface [polypeptide binding]; other site 1327988008393 tetramer interface [polypeptide binding]; other site 1327988008394 TPP binding site [chemical binding]; other site 1327988008395 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1327988008396 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1327988008397 TPP-binding site [chemical binding]; other site 1327988008398 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1327988008399 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 1327988008400 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1327988008401 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1327988008402 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 1327988008403 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 1327988008404 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1327988008405 HTH domain; Region: HTH_11; pfam08279 1327988008406 PRD domain; Region: PRD; pfam00874 1327988008407 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1327988008408 active site 1327988008409 phosphorylation site [posttranslational modification] 1327988008410 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 1327988008411 classical (c) SDRs; Region: SDR_c; cd05233 1327988008412 NAD(P) binding site [chemical binding]; other site 1327988008413 active site 1327988008414 Sugar transport protein; Region: Sugar_transport; pfam06800 1327988008415 D-ribose pyranase; Provisional; Region: PRK11797 1327988008416 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1327988008417 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1327988008418 substrate binding site [chemical binding]; other site 1327988008419 dimer interface [polypeptide binding]; other site 1327988008420 ATP binding site [chemical binding]; other site 1327988008421 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1327988008422 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1327988008423 DNA binding site [nucleotide binding] 1327988008424 domain linker motif; other site 1327988008425 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1327988008426 dimerization interface [polypeptide binding]; other site 1327988008427 ligand binding site [chemical binding]; other site 1327988008428 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1327988008429 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1327988008430 putative catalytic cysteine [active] 1327988008431 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1327988008432 putative active site [active] 1327988008433 metal binding site [ion binding]; metal-binding site 1327988008434 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1327988008435 Ligand Binding Site [chemical binding]; other site 1327988008436 Predicted transcriptional regulators [Transcription]; Region: COG1695 1327988008437 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1327988008438 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1327988008439 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 1327988008440 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1327988008441 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1327988008442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1327988008443 Coenzyme A binding pocket [chemical binding]; other site 1327988008444 EDD domain protein, DegV family; Region: DegV; TIGR00762 1327988008445 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1327988008446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988008447 non-specific DNA binding site [nucleotide binding]; other site 1327988008448 salt bridge; other site 1327988008449 sequence-specific DNA binding site [nucleotide binding]; other site 1327988008450 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1327988008451 trimer interface [polypeptide binding]; other site 1327988008452 active site 1327988008453 G bulge; other site 1327988008454 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1327988008455 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1327988008456 Catalytic site [active] 1327988008457 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1327988008458 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1327988008459 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1327988008460 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1327988008461 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1327988008462 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1327988008463 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1327988008464 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1327988008465 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1327988008466 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1327988008467 G1 box; other site 1327988008468 GTP/Mg2+ binding site [chemical binding]; other site 1327988008469 Switch I region; other site 1327988008470 G2 box; other site 1327988008471 Switch II region; other site 1327988008472 G3 box; other site 1327988008473 G4 box; other site 1327988008474 G5 box; other site 1327988008475 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1327988008476 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1327988008477 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1327988008478 G-X-X-G motif; other site 1327988008479 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1327988008480 RxxxH motif; other site 1327988008481 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1327988008482 Amidohydrolase; Region: Amidohydro_4; pfam13147 1327988008483 active site 1327988008484 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1327988008485 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1327988008486 peptide binding site [polypeptide binding]; other site 1327988008487 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1327988008488 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1327988008489 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1327988008490 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1327988008491 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 1327988008492 putative active site [active] 1327988008493 putative NTP binding site [chemical binding]; other site 1327988008494 putative nucleic acid binding site [nucleotide binding]; other site 1327988008495 Initiator Replication protein; Region: Rep_3; pfam01051 1327988008496 MobA/MobL family; Region: MobA_MobL; pfam03389 1327988008497 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 1327988008498 Zeta toxin; Region: Zeta_toxin; pfam06414 1327988008499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1327988008500 RelB antitoxin; Region: RelB; cl01171 1327988008501 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1327988008502 plasmid segregation protein ParM; Provisional; Region: PRK13917 1327988008503 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1327988008504 Mg binding site [ion binding]; other site 1327988008505 nucleotide binding site [chemical binding]; other site 1327988008506 putative protofilament interface [polypeptide binding]; other site 1327988008507 DNA adenine methylase (dam); Region: dam; TIGR00571 1327988008508 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1327988008509 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1327988008510 catalytic residues [active] 1327988008511 catalytic nucleophile [active] 1327988008512 Presynaptic Site I dimer interface [polypeptide binding]; other site 1327988008513 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1327988008514 Synaptic Flat tetramer interface [polypeptide binding]; other site 1327988008515 Synaptic Site I dimer interface [polypeptide binding]; other site 1327988008516 DNA binding site [nucleotide binding] 1327988008517 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1327988008518 DNA-binding interface [nucleotide binding]; DNA binding site 1327988008519 Domain of unknown function (DUF955); Region: DUF955; cl01076 1327988008520 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1327988008521 DNA topoisomerase III; Provisional; Region: PRK07726 1327988008522 active site 1327988008523 putative interdomain interaction site [polypeptide binding]; other site 1327988008524 putative metal-binding site [ion binding]; other site 1327988008525 putative nucleotide binding site [chemical binding]; other site 1327988008526 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1327988008527 domain I; other site 1327988008528 DNA binding groove [nucleotide binding] 1327988008529 phosphate binding site [ion binding]; other site 1327988008530 domain II; other site 1327988008531 domain III; other site 1327988008532 nucleotide binding site [chemical binding]; other site 1327988008533 catalytic site [active] 1327988008534 domain IV; other site 1327988008535 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1327988008536 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 1327988008537 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1327988008538 Walker A motif; other site 1327988008539 ATP binding site [chemical binding]; other site 1327988008540 Walker B motif; other site 1327988008541 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1327988008542 catalytic residues [active] 1327988008543 NlpC/P60 family; Region: NLPC_P60; cl17555 1327988008544 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1327988008545 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1327988008546 AAA-like domain; Region: AAA_10; pfam12846 1327988008547 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 1327988008548 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1327988008549 MULE transposase domain; Region: MULE; pfam10551 1327988008550 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1327988008551 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1327988008552 P-loop; other site 1327988008553 Magnesium ion binding site [ion binding]; other site 1327988008554 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1327988008555 Magnesium ion binding site [ion binding]; other site 1327988008556 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1327988008557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1327988008558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1327988008559 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 1327988008560 MobA/MobL family; Region: MobA_MobL; pfam03389 1327988008561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1327988008562 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1327988008563 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 1327988008564 catalytic triad [active] 1327988008565 putative active site [active] 1327988008566 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 1327988008567 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1327988008568 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1327988008569 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988008570 Helix-turn-helix domain; Region: HTH_38; pfam13936 1327988008571 Integrase core domain; Region: rve; pfam00665 1327988008572 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1327988008573 MULE transposase domain; Region: MULE; pfam10551 1327988008574 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 1327988008575 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1327988008576 DXD motif; other site 1327988008577 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1327988008578 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1327988008579 Integrase core domain; Region: rve; pfam00665 1327988008580 Integrase core domain; Region: rve_3; pfam13683 1327988008581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1327988008582 Transposase; Region: HTH_Tnp_1; pfam01527 1327988008583 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1327988008584 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1327988008585 catalytic residues [active] 1327988008586 catalytic nucleophile [active] 1327988008587 Presynaptic Site I dimer interface [polypeptide binding]; other site 1327988008588 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1327988008589 Synaptic Flat tetramer interface [polypeptide binding]; other site 1327988008590 Synaptic Site I dimer interface [polypeptide binding]; other site 1327988008591 DNA binding site [nucleotide binding] 1327988008592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1327988008593 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1327988008594 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1327988008595 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1327988008596 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1327988008597 FeS/SAM binding site; other site 1327988008598 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1327988008599 ATP cone domain; Region: ATP-cone; pfam03477 1327988008600 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1327988008601 effector binding site; other site 1327988008602 active site 1327988008603 Zn binding site [ion binding]; other site 1327988008604 glycine loop; other site 1327988008605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1327988008606 Integrase core domain; Region: rve; pfam00665 1327988008607 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 1327988008608 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1327988008609 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1327988008610 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 1327988008611 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1327988008612 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1327988008613 dinuclear metal binding motif [ion binding]; other site 1327988008614 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1327988008615 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1327988008616 dimer interface [polypeptide binding]; other site 1327988008617 putative radical transfer pathway; other site 1327988008618 diiron center [ion binding]; other site 1327988008619 tyrosyl radical; other site 1327988008620 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1327988008621 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988008622 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1327988008623 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1327988008624 catalytic residues [active] 1327988008625 catalytic nucleophile [active] 1327988008626 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1327988008627 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1327988008628 Cl- selectivity filter; other site 1327988008629 Cl- binding residues [ion binding]; other site 1327988008630 pore gating glutamate residue; other site 1327988008631 dimer interface [polypeptide binding]; other site 1327988008632 H+/Cl- coupling transport residue; other site 1327988008633 TrkA-C domain; Region: TrkA_C; pfam02080 1327988008634 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1327988008635 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1327988008636 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1327988008637 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1327988008638 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1327988008639 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1327988008640 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1327988008641 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1327988008642 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1327988008643 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1327988008644 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1327988008645 catalytic residues [active] 1327988008646 catalytic nucleophile [active] 1327988008647 Presynaptic Site I dimer interface [polypeptide binding]; other site 1327988008648 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1327988008649 Synaptic Flat tetramer interface [polypeptide binding]; other site 1327988008650 Synaptic Site I dimer interface [polypeptide binding]; other site 1327988008651 DNA binding site [nucleotide binding] 1327988008652 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1327988008653 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1327988008654 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1327988008655 active site 1327988008656 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1327988008657 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1327988008658 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1327988008659 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1327988008660 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1327988008661 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1327988008662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1327988008663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1327988008664 MarR family; Region: MarR; pfam01047 1327988008665 K+ potassium transporter; Region: K_trans; pfam02705 1327988008666 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1327988008667 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1327988008668 catalytic residues [active] 1327988008669 catalytic nucleophile [active] 1327988008670 Presynaptic Site I dimer interface [polypeptide binding]; other site 1327988008671 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1327988008672 Synaptic Flat tetramer interface [polypeptide binding]; other site 1327988008673 Synaptic Site I dimer interface [polypeptide binding]; other site 1327988008674 DNA binding site [nucleotide binding] 1327988008675 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1327988008676 DNA-binding interface [nucleotide binding]; DNA binding site 1327988008677 FRG domain; Region: FRG; pfam08867 1327988008678 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1327988008679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988008680 putative substrate translocation pore; other site 1327988008681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1327988008682 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1327988008683 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1327988008684 Zn2+ binding site [ion binding]; other site 1327988008685 Mg2+ binding site [ion binding]; other site 1327988008686 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1327988008687 Domain of unknown function (DUF955); Region: DUF955; cl01076 1327988008688 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1327988008689 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1327988008690 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1327988008691 Acetokinase family; Region: Acetate_kinase; cl17229 1327988008692 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 1327988008693 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1327988008694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1327988008695 homodimer interface [polypeptide binding]; other site 1327988008696 catalytic residue [active] 1327988008697 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 1327988008698 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1327988008699 TrkA-C domain; Region: TrkA_C; pfam02080 1327988008700 TrkA-C domain; Region: TrkA_C; pfam02080 1327988008701 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1327988008702 MobA/MobL family; Region: MobA_MobL; pfam03389 1327988008703 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 1327988008704 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1327988008705 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1327988008706 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1327988008707 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1327988008708 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1327988008709 Cl binding site [ion binding]; other site 1327988008710 oligomer interface [polypeptide binding]; other site 1327988008711 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1327988008712 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1327988008713 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1327988008714 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1327988008715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 1327988008716 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1327988008717 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1327988008718 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1327988008719 P-loop; other site 1327988008720 Magnesium ion binding site [ion binding]; other site 1327988008721 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1327988008722 Magnesium ion binding site [ion binding]; other site 1327988008723 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988008724 Helix-turn-helix domain; Region: HTH_38; pfam13936 1327988008725 Integrase core domain; Region: rve; pfam00665 1327988008726 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988008727 Integrase core domain; Region: rve; pfam00665 1327988008728 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1327988008729 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1327988008730 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1327988008731 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1327988008732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1327988008733 dimer interface [polypeptide binding]; other site 1327988008734 conserved gate region; other site 1327988008735 putative PBP binding loops; other site 1327988008736 ABC-ATPase subunit interface; other site 1327988008737 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1327988008738 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1327988008739 Walker A/P-loop; other site 1327988008740 ATP binding site [chemical binding]; other site 1327988008741 Q-loop/lid; other site 1327988008742 ABC transporter signature motif; other site 1327988008743 Walker B; other site 1327988008744 D-loop; other site 1327988008745 H-loop/switch region; other site 1327988008746 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1327988008747 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988008748 Helix-turn-helix domain; Region: HTH_38; pfam13936 1327988008749 Homeodomain-like domain; Region: HTH_32; pfam13565 1327988008750 Integrase core domain; Region: rve; pfam00665 1327988008751 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1327988008752 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1327988008753 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1327988008754 MULE transposase domain; Region: MULE; pfam10551 1327988008755 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1327988008756 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1327988008757 substrate binding site; other site 1327988008758 tetramer interface; other site 1327988008759 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1327988008760 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1327988008761 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1327988008762 NAD binding site [chemical binding]; other site 1327988008763 substrate binding site [chemical binding]; other site 1327988008764 homodimer interface [polypeptide binding]; other site 1327988008765 active site 1327988008766 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1327988008767 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1327988008768 NADP binding site [chemical binding]; other site 1327988008769 active site 1327988008770 putative substrate binding site [chemical binding]; other site 1327988008771 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1327988008772 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1327988008773 Chain length determinant protein; Region: Wzz; cl15801 1327988008774 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1327988008775 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1327988008776 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1327988008777 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1327988008778 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1327988008779 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1327988008780 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 1327988008781 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1327988008782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1327988008783 NAD(P) binding site [chemical binding]; other site 1327988008784 active site 1327988008785 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1327988008786 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1327988008787 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1327988008788 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1327988008789 trimer interface [polypeptide binding]; other site 1327988008790 active site 1327988008791 substrate binding site [chemical binding]; other site 1327988008792 CoA binding site [chemical binding]; other site 1327988008793 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1327988008794 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1327988008795 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1327988008796 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1327988008797 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1327988008798 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1327988008799 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1327988008800 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1327988008801 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1327988008802 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1327988008803 Integrase core domain; Region: rve; pfam00665 1327988008804 putative transposase OrfB; Reviewed; Region: PHA02517 1327988008805 HTH-like domain; Region: HTH_21; pfam13276 1327988008806 Integrase core domain; Region: rve; pfam00665 1327988008807 Integrase core domain; Region: rve_3; pfam13683 1327988008808 Transposase; Region: HTH_Tnp_1; pfam01527 1327988008809 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1327988008810 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1327988008811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988008812 Walker A motif; other site 1327988008813 ATP binding site [chemical binding]; other site 1327988008814 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1327988008815 MULE transposase domain; Region: MULE; pfam10551 1327988008816 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1327988008817 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1327988008818 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988008819 Helix-turn-helix domain; Region: HTH_38; pfam13936 1327988008820 Integrase core domain; Region: rve; pfam00665 1327988008821 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1327988008822 Dimer interface [polypeptide binding]; other site 1327988008823 BRCT sequence motif; other site 1327988008824 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1327988008825 Walker A motif; other site 1327988008826 ATP binding site [chemical binding]; other site 1327988008827 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 1327988008828 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1327988008829 DNA polymerase IV; Reviewed; Region: PRK03103 1327988008830 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1327988008831 active site 1327988008832 DNA binding site [nucleotide binding] 1327988008833 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1327988008834 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1327988008835 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1327988008836 P-loop; other site 1327988008837 Magnesium ion binding site [ion binding]; other site 1327988008838 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1327988008839 Magnesium ion binding site [ion binding]; other site 1327988008840 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 1327988008841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1327988008842 DNA-binding site [nucleotide binding]; DNA binding site 1327988008843 AAA-like domain; Region: AAA_10; pfam12846 1327988008844 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1327988008845 NlpC/P60 family; Region: NLPC_P60; cl17555 1327988008846 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 1327988008847 cell division protein MukB; Provisional; Region: mukB; PRK04863 1327988008848 CAAX protease self-immunity; Region: Abi; pfam02517 1327988008849 HTH-like domain; Region: HTH_21; pfam13276 1327988008850 Integrase core domain; Region: rve; pfam00665 1327988008851 Integrase core domain; Region: rve_3; pfam13683 1327988008852 Helix-turn-helix domain; Region: HTH_28; pfam13518 1327988008853 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1327988008854 DNA topoisomerase III; Provisional; Region: PRK07726 1327988008855 active site 1327988008856 putative interdomain interaction site [polypeptide binding]; other site 1327988008857 putative metal-binding site [ion binding]; other site 1327988008858 putative nucleotide binding site [chemical binding]; other site 1327988008859 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1327988008860 domain I; other site 1327988008861 DNA binding groove [nucleotide binding] 1327988008862 phosphate binding site [ion binding]; other site 1327988008863 domain II; other site 1327988008864 domain III; other site 1327988008865 nucleotide binding site [chemical binding]; other site 1327988008866 catalytic site [active] 1327988008867 domain IV; other site 1327988008868 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1327988008869 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1327988008870 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 1327988008871 Toprim-like; Region: Toprim_2; pfam13155 1327988008872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988008873 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1327988008874 Walker A motif; other site 1327988008875 ATP binding site [chemical binding]; other site 1327988008876 Walker B motif; other site 1327988008877 arginine finger; other site 1327988008878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988008879 Walker A motif; other site 1327988008880 ATP binding site [chemical binding]; other site 1327988008881 Walker B motif; other site 1327988008882 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1327988008883 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 1327988008884 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1327988008885 active site 1327988008886 catalytic site [active] 1327988008887 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1327988008888 putative transposase OrfB; Reviewed; Region: PHA02517 1327988008889 HTH-like domain; Region: HTH_21; pfam13276 1327988008890 Integrase core domain; Region: rve; pfam00665 1327988008891 Integrase core domain; Region: rve_3; pfam13683 1327988008892 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1327988008893 Transposase; Region: HTH_Tnp_1; pfam01527 1327988008894 Helix-turn-helix domain; Region: HTH_17; pfam12728 1327988008895 Predicted integral membrane protein [Function unknown]; Region: COG5617 1327988008896 PemK-like protein; Region: PemK; pfam02452 1327988008897 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1327988008898 Initiator Replication protein; Region: Rep_3; pfam01051 1327988008899 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1327988008900 active site 1327988008901 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988008902 Integrase core domain; Region: rve; pfam00665 1327988008903 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1327988008904 MULE transposase domain; Region: MULE; pfam10551 1327988008905 Integrase core domain; Region: rve; pfam00665 1327988008906 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988008907 PspC domain; Region: PspC; pfam04024 1327988008908 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1327988008909 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1327988008910 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1327988008911 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1327988008912 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1327988008913 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1327988008914 DAK2 domain; Region: Dak2; cl03685 1327988008915 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1327988008916 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1327988008917 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988008918 Helix-turn-helix domain; Region: HTH_38; pfam13936 1327988008919 Integrase core domain; Region: rve; pfam00665 1327988008920 PHP domain; Region: PHP; pfam02811 1327988008921 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1327988008922 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1327988008923 AAA domain; Region: AAA_23; pfam13476 1327988008924 Walker A/P-loop; other site 1327988008925 ATP binding site [chemical binding]; other site 1327988008926 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1327988008927 active site 1327988008928 MarR family; Region: MarR; pfam01047 1327988008929 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1327988008930 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1327988008931 catalytic residues [active] 1327988008932 catalytic nucleophile [active] 1327988008933 Presynaptic Site I dimer interface [polypeptide binding]; other site 1327988008934 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1327988008935 Synaptic Flat tetramer interface [polypeptide binding]; other site 1327988008936 Synaptic Site I dimer interface [polypeptide binding]; other site 1327988008937 DNA binding site [nucleotide binding] 1327988008938 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1327988008939 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1327988008940 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1327988008941 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 1327988008942 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1327988008943 active site 1327988008944 catalytic site [active] 1327988008945 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1327988008946 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1327988008947 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1327988008948 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1327988008949 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1327988008950 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1327988008951 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1327988008952 Fic/DOC family; Region: Fic; pfam02661 1327988008953 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 1327988008954 MobA/MobL family; Region: MobA_MobL; pfam03389 1327988008955 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 1327988008956 domain III; other site 1327988008957 nucleotide binding site [chemical binding]; other site 1327988008958 catalytic site [active] 1327988008959 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1327988008960 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1327988008961 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1327988008962 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1327988008963 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1327988008964 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1327988008965 Pleckstrin homology-like domain; Region: PH-like; cl17171 1327988008966 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1327988008967 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1327988008968 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1327988008969 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1327988008970 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1327988008971 NAD binding site [chemical binding]; other site 1327988008972 catalytic residues [active] 1327988008973 substrate binding site [chemical binding]; other site 1327988008974 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1327988008975 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 1327988008976 catalytic Zn binding site [ion binding]; other site 1327988008977 NAD binding site [chemical binding]; other site 1327988008978 structural Zn binding site [ion binding]; other site 1327988008979 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988008980 Integrase core domain; Region: rve; pfam00665 1327988008981 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1327988008982 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1327988008983 P-loop; other site 1327988008984 Magnesium ion binding site [ion binding]; other site 1327988008985 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1327988008986 Magnesium ion binding site [ion binding]; other site 1327988008987 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 1327988008988 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1327988008989 DNA-binding site [nucleotide binding]; DNA binding site 1327988008990 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1327988008991 AAA-like domain; Region: AAA_10; pfam12846 1327988008992 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1327988008993 NlpC/P60 family; Region: NLPC_P60; cl17555 1327988008994 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 1327988008995 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1327988008996 catalytic residues [active] 1327988008997 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1327988008998 CAAX protease self-immunity; Region: Abi; pfam02517 1327988008999 HTH-like domain; Region: HTH_21; pfam13276 1327988009000 Integrase core domain; Region: rve; pfam00665 1327988009001 Integrase core domain; Region: rve_3; pfam13683 1327988009002 Helix-turn-helix domain; Region: HTH_28; pfam13518 1327988009003 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1327988009004 DNA topoisomerase III; Provisional; Region: PRK07726 1327988009005 active site 1327988009006 putative interdomain interaction site [polypeptide binding]; other site 1327988009007 putative metal-binding site [ion binding]; other site 1327988009008 putative nucleotide binding site [chemical binding]; other site 1327988009009 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1327988009010 domain I; other site 1327988009011 DNA binding groove [nucleotide binding] 1327988009012 phosphate binding site [ion binding]; other site 1327988009013 domain II; other site 1327988009014 domain III; other site 1327988009015 nucleotide binding site [chemical binding]; other site 1327988009016 catalytic site [active] 1327988009017 domain IV; other site 1327988009018 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1327988009019 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1327988009020 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 1327988009021 Toprim-like; Region: Toprim_2; pfam13155 1327988009022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988009023 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1327988009024 Walker A motif; other site 1327988009025 ATP binding site [chemical binding]; other site 1327988009026 Walker B motif; other site 1327988009027 arginine finger; other site 1327988009028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1327988009029 Walker A motif; other site 1327988009030 ATP binding site [chemical binding]; other site 1327988009031 Walker B motif; other site 1327988009032 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1327988009033 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 1327988009034 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1327988009035 active site 1327988009036 catalytic site [active] 1327988009037 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1327988009038 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988009039 Helix-turn-helix domain; Region: HTH_38; pfam13936 1327988009040 Integrase core domain; Region: rve; pfam00665 1327988009041 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1327988009042 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1327988009043 catalytic residues [active] 1327988009044 catalytic nucleophile [active] 1327988009045 Presynaptic Site I dimer interface [polypeptide binding]; other site 1327988009046 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1327988009047 Synaptic Flat tetramer interface [polypeptide binding]; other site 1327988009048 Synaptic Site I dimer interface [polypeptide binding]; other site 1327988009049 DNA binding site [nucleotide binding] 1327988009050 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1327988009051 DNA-binding interface [nucleotide binding]; DNA binding site 1327988009052 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1327988009053 Ligand Binding Site [chemical binding]; other site 1327988009054 manganese transport protein MntH; Reviewed; Region: PRK00701 1327988009055 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1327988009056 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1327988009057 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1327988009058 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1327988009059 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988009060 Helix-turn-helix domain; Region: HTH_38; pfam13936 1327988009061 Integrase core domain; Region: rve; pfam00665 1327988009062 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1327988009063 Integrase core domain; Region: rve; pfam00665 1327988009064 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1327988009065 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1327988009066 P-loop; other site 1327988009067 Magnesium ion binding site [ion binding]; other site 1327988009068 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1327988009069 Magnesium ion binding site [ion binding]; other site 1327988009070 MobA/MobL family; Region: MobA_MobL; pfam03389 1327988009071 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1327988009072 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1327988009073 Helix-turn-helix domain; Region: HTH_38; pfam13936 1327988009074 Integrase core domain; Region: rve; pfam00665 1327988009075 Helix-turn-helix domain; Region: HTH_17; pfam12728 1327988009076 Initiator Replication protein; Region: Rep_3; pfam01051 1327988009077 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1327988009078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1327988009079 non-specific DNA binding site [nucleotide binding]; other site 1327988009080 salt bridge; other site 1327988009081 sequence-specific DNA binding site [nucleotide binding]; other site 1327988009082 CAAX protease self-immunity; Region: Abi; pfam02517