-- dump date 20140619_124025 -- class Genbank::misc_feature -- table misc_feature_note -- id note 644042000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 644042000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 644042000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042000004 Walker A motif; other site 644042000005 ATP binding site [chemical binding]; other site 644042000006 Walker B motif; other site 644042000007 arginine finger; other site 644042000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 644042000009 DnaA box-binding interface [nucleotide binding]; other site 644042000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 644042000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 644042000012 putative DNA binding surface [nucleotide binding]; other site 644042000013 dimer interface [polypeptide binding]; other site 644042000014 beta-clamp/clamp loader binding surface; other site 644042000015 beta-clamp/translesion DNA polymerase binding surface; other site 644042000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 644042000017 recombination protein F; Reviewed; Region: recF; PRK00064 644042000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 644042000019 Walker A/P-loop; other site 644042000020 ATP binding site [chemical binding]; other site 644042000021 Q-loop/lid; other site 644042000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042000023 ABC transporter signature motif; other site 644042000024 Walker B; other site 644042000025 D-loop; other site 644042000026 H-loop/switch region; other site 644042000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 644042000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644042000029 Mg2+ binding site [ion binding]; other site 644042000030 G-X-G motif; other site 644042000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 644042000032 anchoring element; other site 644042000033 dimer interface [polypeptide binding]; other site 644042000034 ATP binding site [chemical binding]; other site 644042000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 644042000036 active site 644042000037 putative metal-binding site [ion binding]; other site 644042000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 644042000039 DNA gyrase subunit A; Validated; Region: PRK05560 644042000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 644042000041 CAP-like domain; other site 644042000042 active site 644042000043 primary dimer interface [polypeptide binding]; other site 644042000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644042000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644042000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644042000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644042000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644042000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644042000050 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 644042000051 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 644042000052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 644042000053 dimer interface [polypeptide binding]; other site 644042000054 ssDNA binding site [nucleotide binding]; other site 644042000055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 644042000056 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 644042000057 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 644042000058 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 644042000059 metal binding site [ion binding]; metal-binding site 644042000060 DHH family; Region: DHH; pfam01368 644042000061 DHHA1 domain; Region: DHHA1; pfam02272 644042000062 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 644042000063 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 644042000064 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 644042000065 replicative DNA helicase; Provisional; Region: PRK05748 644042000066 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 644042000067 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 644042000068 Walker A motif; other site 644042000069 ATP binding site [chemical binding]; other site 644042000070 Walker B motif; other site 644042000071 DNA binding loops [nucleotide binding] 644042000072 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 644042000073 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 644042000074 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 644042000075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042000076 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042000077 putative substrate translocation pore; other site 644042000078 gamma-glutamyl kinase; Provisional; Region: PRK05429 644042000079 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 644042000080 nucleotide binding site [chemical binding]; other site 644042000081 homotetrameric interface [polypeptide binding]; other site 644042000082 putative phosphate binding site [ion binding]; other site 644042000083 putative allosteric binding site; other site 644042000084 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 644042000085 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 644042000086 putative catalytic cysteine [active] 644042000087 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 644042000088 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 644042000089 peptide binding site [polypeptide binding]; other site 644042000090 glycogen branching enzyme; Provisional; Region: PRK12313 644042000091 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 644042000092 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 644042000093 active site 644042000094 catalytic site [active] 644042000095 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 644042000096 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 644042000097 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 644042000098 ligand binding site; other site 644042000099 oligomer interface; other site 644042000100 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 644042000101 dimer interface [polypeptide binding]; other site 644042000102 N-terminal domain interface [polypeptide binding]; other site 644042000103 sulfate 1 binding site; other site 644042000104 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 644042000105 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 644042000106 ligand binding site; other site 644042000107 oligomer interface; other site 644042000108 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 644042000109 dimer interface [polypeptide binding]; other site 644042000110 N-terminal domain interface [polypeptide binding]; other site 644042000111 sulfate 1 binding site; other site 644042000112 glycogen synthase; Provisional; Region: glgA; PRK00654 644042000113 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 644042000114 ADP-binding pocket [chemical binding]; other site 644042000115 homodimer interface [polypeptide binding]; other site 644042000116 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 644042000117 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 644042000118 active site pocket [active] 644042000119 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 644042000120 active site 644042000121 homodimer interface [polypeptide binding]; other site 644042000122 catalytic site [active] 644042000123 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 644042000124 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042000125 active site 644042000126 motif I; other site 644042000127 motif II; other site 644042000128 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 644042000129 beta-phosphoglucomutase; Region: bPGM; TIGR01990 644042000130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042000131 motif II; other site 644042000132 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 644042000133 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 644042000134 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 644042000135 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 644042000136 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 644042000137 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 644042000138 DNA-binding site [nucleotide binding]; DNA binding site 644042000139 RNA-binding motif; other site 644042000140 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 644042000141 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 644042000142 Int/Topo IB signature motif; other site 644042000143 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644042000144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042000145 non-specific DNA binding site [nucleotide binding]; other site 644042000146 salt bridge; other site 644042000147 sequence-specific DNA binding site [nucleotide binding]; other site 644042000148 Helix-turn-helix domain; Region: HTH_17; cl17695 644042000149 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 644042000150 polymerase nucleotide-binding site; other site 644042000151 DNA-binding residues [nucleotide binding]; DNA binding site 644042000152 nucleotide binding site [chemical binding]; other site 644042000153 primase nucleotide-binding site [nucleotide binding]; other site 644042000154 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 644042000155 Virulence-associated protein E; Region: VirE; pfam05272 644042000156 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 644042000157 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 644042000158 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 644042000159 active site 644042000160 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 644042000161 Helix-turn-helix domain; Region: HTH_38; pfam13936 644042000162 Homeodomain-like domain; Region: HTH_32; pfam13565 644042000163 Integrase core domain; Region: rve; pfam00665 644042000164 Phage terminase, small subunit; Region: Terminase_4; pfam05119 644042000165 potential frameshift: common BLAST hit: gi|28379026|ref|NP_785918.1| prophage Lp3 protein 15, terminase large subunit 644042000166 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 644042000167 Phage Terminase; Region: Terminase_1; pfam03354 644042000168 Phage-related protein [Function unknown]; Region: COG4695; cl01923 644042000169 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 644042000170 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 644042000171 Phage capsid family; Region: Phage_capsid; pfam05065 644042000172 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 644042000173 oligomerization interface [polypeptide binding]; other site 644042000174 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 644042000175 DNA-binding site [nucleotide binding]; DNA binding site 644042000176 RNA-binding motif; other site 644042000177 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644042000178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644042000179 active site 644042000180 phosphorylation site [posttranslational modification] 644042000181 intermolecular recognition site; other site 644042000182 dimerization interface [polypeptide binding]; other site 644042000183 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644042000184 DNA binding site [nucleotide binding] 644042000185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 644042000186 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644042000187 dimerization interface [polypeptide binding]; other site 644042000188 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 644042000189 putative active site [active] 644042000190 heme pocket [chemical binding]; other site 644042000191 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644042000192 dimer interface [polypeptide binding]; other site 644042000193 phosphorylation site [posttranslational modification] 644042000194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644042000195 ATP binding site [chemical binding]; other site 644042000196 Mg2+ binding site [ion binding]; other site 644042000197 G-X-G motif; other site 644042000198 YycH protein; Region: YycH; pfam07435 644042000199 YycH protein; Region: YycI; pfam09648 644042000200 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 644042000201 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 644042000202 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 644042000203 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 644042000204 protein binding site [polypeptide binding]; other site 644042000205 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 644042000206 hypothetical protein; Provisional; Region: PRK10621 644042000207 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 644042000208 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 644042000209 putative uracil binding site [chemical binding]; other site 644042000210 putative active site [active] 644042000211 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 644042000212 putative FMN binding site [chemical binding]; other site 644042000213 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 644042000214 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 644042000215 Predicted flavoprotein [General function prediction only]; Region: COG0431 644042000216 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 644042000217 FAD binding domain; Region: FAD_binding_2; pfam00890 644042000218 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 644042000219 FMN-binding domain; Region: FMN_bind; cl01081 644042000220 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 644042000221 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 644042000222 transmembrane helices; other site 644042000223 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042000224 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042000225 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644042000226 dimerization interface [polypeptide binding]; other site 644042000227 flavodoxin; Provisional; Region: PRK06242 644042000228 Low molecular weight phosphatase family; Region: LMWPc; cl00105 644042000229 hypothetical protein; Provisional; Region: PRK06194 644042000230 classical (c) SDRs; Region: SDR_c; cd05233 644042000231 NAD(P) binding site [chemical binding]; other site 644042000232 active site 644042000233 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 644042000234 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 644042000235 dimer interface [polypeptide binding]; other site 644042000236 FMN binding site [chemical binding]; other site 644042000237 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 644042000238 beta-phosphoglucomutase; Region: bPGM; TIGR01990 644042000239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042000240 motif II; other site 644042000241 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 644042000242 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 644042000243 active site 644042000244 Uncharacterized conserved protein [Function unknown]; Region: COG2966 644042000245 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 644042000246 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 644042000247 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 644042000248 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 644042000249 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 644042000250 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 644042000251 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 644042000252 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 644042000253 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 644042000254 catalytic triad [active] 644042000255 Predicted transcriptional regulator [Transcription]; Region: COG2378 644042000256 HTH domain; Region: HTH_11; pfam08279 644042000257 WYL domain; Region: WYL; pfam13280 644042000258 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 644042000259 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 644042000260 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 644042000261 G1 box; other site 644042000262 putative GEF interaction site [polypeptide binding]; other site 644042000263 GTP/Mg2+ binding site [chemical binding]; other site 644042000264 Switch I region; other site 644042000265 G2 box; other site 644042000266 G3 box; other site 644042000267 Switch II region; other site 644042000268 G4 box; other site 644042000269 G5 box; other site 644042000270 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 644042000271 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 644042000272 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 644042000273 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 644042000274 Protein of unknown function; Region: DUF3658; pfam12395 644042000275 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 644042000276 EamA-like transporter family; Region: EamA; pfam00892 644042000277 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 644042000278 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 644042000279 potential catalytic triad [active] 644042000280 conserved cys residue [active] 644042000281 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 644042000282 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 644042000283 putative NAD(P) binding site [chemical binding]; other site 644042000284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644042000285 dimerization interface [polypeptide binding]; other site 644042000286 putative DNA binding site [nucleotide binding]; other site 644042000287 putative Zn2+ binding site [ion binding]; other site 644042000288 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 644042000289 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 644042000290 potential frameshift: common BLAST hit: gi|28377046|ref|NP_783938.1| prolyl aminopeptidase 644042000291 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 644042000292 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 644042000293 hypothetical protein; Validated; Region: PRK02101 644042000294 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 644042000295 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 644042000296 peptide binding site [polypeptide binding]; other site 644042000297 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 644042000298 active site 644042000299 NTP binding site [chemical binding]; other site 644042000300 metal binding triad [ion binding]; metal-binding site 644042000301 antibiotic binding site [chemical binding]; other site 644042000302 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 644042000303 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644042000304 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 644042000305 Walker A/P-loop; other site 644042000306 ATP binding site [chemical binding]; other site 644042000307 Q-loop/lid; other site 644042000308 ABC transporter signature motif; other site 644042000309 Walker B; other site 644042000310 D-loop; other site 644042000311 H-loop/switch region; other site 644042000312 Cobalt transport protein; Region: CbiQ; cl00463 644042000313 cobalt transport protein CbiM; Provisional; Region: PRK07331 644042000314 cobalt transport protein CbiM; Provisional; Region: PRK11909 644042000315 PDGLE domain; Region: PDGLE; pfam13190 644042000316 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 644042000317 putative switch regulator; other site 644042000318 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 644042000319 non-specific DNA interactions [nucleotide binding]; other site 644042000320 DNA binding site [nucleotide binding] 644042000321 sequence specific DNA binding site [nucleotide binding]; other site 644042000322 putative cAMP binding site [chemical binding]; other site 644042000323 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 644042000324 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 644042000325 AIR carboxylase; Region: AIRC; smart01001 644042000326 Protein of unknown function DUF111; Region: DUF111; cl03398 644042000327 Protein of unknown function DUF111; Region: DUF111; cl03398 644042000328 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 644042000329 amphipathic channel; other site 644042000330 Asn-Pro-Ala signature motifs; other site 644042000331 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 644042000332 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 644042000333 Ligand Binding Site [chemical binding]; other site 644042000334 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 644042000335 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 644042000336 putative NAD(P) binding site [chemical binding]; other site 644042000337 substrate binding site [chemical binding]; other site 644042000338 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 644042000339 substrate binding site [chemical binding]; other site 644042000340 multimerization interface [polypeptide binding]; other site 644042000341 ATP binding site [chemical binding]; other site 644042000342 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 644042000343 dimer interface [polypeptide binding]; other site 644042000344 substrate binding site [chemical binding]; other site 644042000345 ATP binding site [chemical binding]; other site 644042000346 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 644042000347 thiamine phosphate binding site [chemical binding]; other site 644042000348 active site 644042000349 pyrophosphate binding site [ion binding]; other site 644042000350 putative hydroxymethylpyrimidine transporter CytX; Region: thia_cytX; TIGR02358 644042000351 Na binding site [ion binding]; other site 644042000352 Peptidase C26; Region: Peptidase_C26; pfam07722 644042000353 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 644042000354 catalytic triad [active] 644042000355 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 644042000356 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 644042000357 nudix motif; other site 644042000358 putative transport protein YifK; Provisional; Region: PRK10746 644042000359 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 644042000360 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 644042000361 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 644042000362 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644042000363 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 644042000364 Soluble P-type ATPase [General function prediction only]; Region: COG4087 644042000365 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 644042000366 PspC domain; Region: PspC; pfam04024 644042000367 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 644042000368 Predicted flavoprotein [General function prediction only]; Region: COG0431 644042000369 Transcriptional regulators [Transcription]; Region: MarR; COG1846 644042000370 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 644042000371 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 644042000372 putative dimer interface [polypeptide binding]; other site 644042000373 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 644042000374 LytTr DNA-binding domain; Region: LytTR; cl04498 644042000375 drug efflux system protein MdtG; Provisional; Region: PRK09874 644042000376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042000377 putative substrate translocation pore; other site 644042000378 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644042000379 dimerization interface [polypeptide binding]; other site 644042000380 putative DNA binding site [nucleotide binding]; other site 644042000381 putative Zn2+ binding site [ion binding]; other site 644042000382 cyanate transporter; Region: CynX; TIGR00896 644042000383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042000384 putative substrate translocation pore; other site 644042000385 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644042000386 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644042000387 active site 644042000388 catalytic tetrad [active] 644042000389 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644042000390 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644042000391 active site 644042000392 catalytic tetrad [active] 644042000393 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 644042000394 myosin-cross-reactive antigen; Provisional; Region: PRK13977 644042000395 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 644042000396 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 644042000397 putative active site [active] 644042000398 putative FMN binding site [chemical binding]; other site 644042000399 putative substrate binding site [chemical binding]; other site 644042000400 putative catalytic residue [active] 644042000401 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 644042000402 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644042000403 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 644042000404 Walker A/P-loop; other site 644042000405 ATP binding site [chemical binding]; other site 644042000406 Q-loop/lid; other site 644042000407 ABC transporter signature motif; other site 644042000408 Walker B; other site 644042000409 D-loop; other site 644042000410 H-loop/switch region; other site 644042000411 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 644042000412 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644042000413 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 644042000414 Walker A/P-loop; other site 644042000415 ATP binding site [chemical binding]; other site 644042000416 Q-loop/lid; other site 644042000417 ABC transporter signature motif; other site 644042000418 Walker B; other site 644042000419 D-loop; other site 644042000420 H-loop/switch region; other site 644042000421 hypothetical protein; Provisional; Region: PRK13661 644042000422 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 644042000423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042000424 DNA-binding site [nucleotide binding]; DNA binding site 644042000425 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 644042000426 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 644042000427 classical (c) SDRs; Region: SDR_c; cd05233 644042000428 NAD(P) binding site [chemical binding]; other site 644042000429 active site 644042000430 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 644042000431 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 644042000432 Walker A/P-loop; other site 644042000433 ATP binding site [chemical binding]; other site 644042000434 Q-loop/lid; other site 644042000435 ABC transporter signature motif; other site 644042000436 Walker B; other site 644042000437 D-loop; other site 644042000438 H-loop/switch region; other site 644042000439 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 644042000440 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 644042000441 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042000442 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644042000443 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 644042000444 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 644042000445 active site 644042000446 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 644042000447 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 644042000448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644042000449 probable dihydroxyacetone kinase DhaK1b subunit; Region: dhaK1b; TIGR02362 644042000450 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 644042000451 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 644042000452 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 644042000453 DAK2 domain; Region: Dak2; cl03685 644042000454 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 644042000455 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 644042000456 amphipathic channel; other site 644042000457 Asn-Pro-Ala signature motifs; other site 644042000458 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644042000459 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644042000460 DNA binding site [nucleotide binding] 644042000461 domain linker motif; other site 644042000462 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 644042000463 putative dimerization interface [polypeptide binding]; other site 644042000464 putative ligand binding site [chemical binding]; other site 644042000465 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644042000466 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644042000467 DNA binding site [nucleotide binding] 644042000468 domain linker motif; other site 644042000469 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 644042000470 ligand binding site [chemical binding]; other site 644042000471 dimerization interface [polypeptide binding]; other site 644042000472 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 644042000473 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 644042000474 Ca binding site [ion binding]; other site 644042000475 active site 644042000476 catalytic site [active] 644042000477 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 644042000478 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 644042000479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042000480 dimer interface [polypeptide binding]; other site 644042000481 conserved gate region; other site 644042000482 putative PBP binding loops; other site 644042000483 ABC-ATPase subunit interface; other site 644042000484 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 644042000485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042000486 dimer interface [polypeptide binding]; other site 644042000487 conserved gate region; other site 644042000488 putative PBP binding loops; other site 644042000489 ABC-ATPase subunit interface; other site 644042000490 Predicted integral membrane protein [Function unknown]; Region: COG5521 644042000491 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 644042000492 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 644042000493 active site 644042000494 catalytic site [active] 644042000495 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 644042000496 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 644042000497 Walker A/P-loop; other site 644042000498 ATP binding site [chemical binding]; other site 644042000499 Q-loop/lid; other site 644042000500 ABC transporter signature motif; other site 644042000501 Walker B; other site 644042000502 D-loop; other site 644042000503 H-loop/switch region; other site 644042000504 TOBE domain; Region: TOBE_2; pfam08402 644042000505 maltose phosphorylase; Provisional; Region: PRK13807 644042000506 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 644042000507 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 644042000508 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 644042000509 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 644042000510 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 644042000511 putative active site [active] 644042000512 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 644042000513 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 644042000514 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 644042000515 sugar binding site [chemical binding]; other site 644042000516 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 644042000517 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644042000518 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 644042000519 nucleotide binding site [chemical binding]; other site 644042000520 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 644042000521 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 644042000522 Melibiase; Region: Melibiase; pfam02065 644042000523 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 644042000524 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644042000525 active site turn [active] 644042000526 phosphorylation site [posttranslational modification] 644042000527 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644042000528 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 644042000529 HPr interaction site; other site 644042000530 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644042000531 active site 644042000532 phosphorylation site [posttranslational modification] 644042000533 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 644042000534 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 644042000535 substrate binding [chemical binding]; other site 644042000536 active site 644042000537 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 644042000538 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644042000539 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644042000540 DNA binding site [nucleotide binding] 644042000541 domain linker motif; other site 644042000542 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 644042000543 dimerization interface [polypeptide binding]; other site 644042000544 ligand binding site [chemical binding]; other site 644042000545 sodium binding site [ion binding]; other site 644042000546 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 644042000547 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 644042000548 Ca binding site [ion binding]; other site 644042000549 active site 644042000550 catalytic site [active] 644042000551 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 644042000552 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 644042000553 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 644042000554 putative NAD(P) binding site [chemical binding]; other site 644042000555 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 644042000556 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 644042000557 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 644042000558 Ca binding site [ion binding]; other site 644042000559 active site 644042000560 catalytic site [active] 644042000561 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 644042000562 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042000563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042000564 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644042000565 dimerization interface [polypeptide binding]; other site 644042000566 Cna protein B-type domain; Region: Cna_B; pfam05738 644042000567 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 644042000568 domain interaction interfaces [polypeptide binding]; other site 644042000569 Cna protein B-type domain; Region: Cna_B; pfam05738 644042000570 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644042000571 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042000572 non-specific DNA binding site [nucleotide binding]; other site 644042000573 salt bridge; other site 644042000574 sequence-specific DNA binding site [nucleotide binding]; other site 644042000575 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 644042000576 peptide binding site [polypeptide binding]; other site 644042000577 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 644042000578 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 644042000579 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 644042000580 peptide binding site [polypeptide binding]; other site 644042000581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 644042000582 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 644042000583 putative ligand binding site [chemical binding]; other site 644042000584 putative NAD binding site [chemical binding]; other site 644042000585 putative catalytic site [active] 644042000586 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 644042000587 L-serine binding site [chemical binding]; other site 644042000588 ACT domain interface; other site 644042000589 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 644042000590 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644042000591 catalytic residue [active] 644042000592 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644042000593 catalytic core [active] 644042000594 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644042000595 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644042000596 active site 644042000597 catalytic tetrad [active] 644042000598 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 644042000599 Domain of unknown function (DU1801); Region: DUF1801; cl17490 644042000600 Domain of unknown function (DUF814); Region: DUF814; pfam05670 644042000601 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 644042000602 propionate/acetate kinase; Provisional; Region: PRK12379 644042000603 CrcB-like protein; Region: CRCB; cl09114 644042000604 CrcB-like protein; Region: CRCB; cl09114 644042000605 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 644042000606 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644042000607 ABC transporter; Region: ABC_tran_2; pfam12848 644042000608 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644042000609 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644042000610 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 644042000611 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644042000612 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 644042000613 Walker A/P-loop; other site 644042000614 ATP binding site [chemical binding]; other site 644042000615 Q-loop/lid; other site 644042000616 ABC transporter signature motif; other site 644042000617 Walker B; other site 644042000618 D-loop; other site 644042000619 H-loop/switch region; other site 644042000620 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 644042000621 AAA domain; Region: AAA_23; pfam13476 644042000622 Walker A/P-loop; other site 644042000623 ATP binding site [chemical binding]; other site 644042000624 ABC transporter; Region: ABC_tran; pfam00005 644042000625 Q-loop/lid; other site 644042000626 ABC transporter signature motif; other site 644042000627 Walker B; other site 644042000628 D-loop; other site 644042000629 H-loop/switch region; other site 644042000630 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 644042000631 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 644042000632 catalytic residues [active] 644042000633 dimer interface [polypeptide binding]; other site 644042000634 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644042000635 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644042000636 active site 644042000637 catalytic tetrad [active] 644042000638 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 644042000639 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 644042000640 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 644042000641 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644042000642 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042000643 non-specific DNA binding site [nucleotide binding]; other site 644042000644 salt bridge; other site 644042000645 sequence-specific DNA binding site [nucleotide binding]; other site 644042000646 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 644042000647 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 644042000648 active site 644042000649 trimer interface [polypeptide binding]; other site 644042000650 allosteric site; other site 644042000651 active site lid [active] 644042000652 hexamer (dimer of trimers) interface [polypeptide binding]; other site 644042000653 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042000654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042000655 putative substrate translocation pore; other site 644042000656 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 644042000657 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 644042000658 Predicted oxidoreductase [General function prediction only]; Region: COG3573 644042000659 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 644042000660 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 644042000661 Peptidase family C69; Region: Peptidase_C69; pfam03577 644042000662 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 644042000663 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 644042000664 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 644042000665 active site 644042000666 P-loop; other site 644042000667 phosphorylation site [posttranslational modification] 644042000668 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 644042000669 active site 644042000670 P-loop; other site 644042000671 phosphorylation site [posttranslational modification] 644042000672 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 644042000673 PRD domain; Region: PRD; pfam00874 644042000674 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 644042000675 active site 644042000676 P-loop; other site 644042000677 phosphorylation site [posttranslational modification] 644042000678 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 644042000679 active site 644042000680 phosphorylation site [posttranslational modification] 644042000681 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 644042000682 active site 644042000683 phosphorylation site [posttranslational modification] 644042000684 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 644042000685 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 644042000686 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 644042000687 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 644042000688 DNA binding residues [nucleotide binding] 644042000689 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 644042000690 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 644042000691 catalytic residues [active] 644042000692 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 644042000693 active site 644042000694 multimer interface [polypeptide binding]; other site 644042000695 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 644042000696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 644042000697 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 644042000698 Predicted flavoprotein [General function prediction only]; Region: COG0431 644042000699 serine O-acetyltransferase; Region: cysE; TIGR01172 644042000700 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 644042000701 trimer interface [polypeptide binding]; other site 644042000702 active site 644042000703 substrate binding site [chemical binding]; other site 644042000704 CoA binding site [chemical binding]; other site 644042000705 cystathionine beta-lyase; Provisional; Region: PRK07671 644042000706 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 644042000707 homodimer interface [polypeptide binding]; other site 644042000708 substrate-cofactor binding pocket; other site 644042000709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042000710 catalytic residue [active] 644042000711 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 644042000712 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 644042000713 dimer interface [polypeptide binding]; other site 644042000714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042000715 catalytic residue [active] 644042000716 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 644042000717 methionine aminopeptidase; Provisional; Region: PRK08671 644042000718 active site 644042000719 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 644042000720 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 644042000721 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 644042000722 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042000723 DNA-binding site [nucleotide binding]; DNA binding site 644042000724 UTRA domain; Region: UTRA; pfam07702 644042000725 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 644042000726 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 644042000727 Ca binding site [ion binding]; other site 644042000728 active site 644042000729 catalytic site [active] 644042000730 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 644042000731 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 644042000732 HPr interaction site; other site 644042000733 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644042000734 active site 644042000735 phosphorylation site [posttranslational modification] 644042000736 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 644042000737 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644042000738 active site turn [active] 644042000739 phosphorylation site [posttranslational modification] 644042000740 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644042000741 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 644042000742 HPr interaction site; other site 644042000743 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644042000744 active site 644042000745 phosphorylation site [posttranslational modification] 644042000746 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 644042000747 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644042000748 active site turn [active] 644042000749 phosphorylation site [posttranslational modification] 644042000750 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644042000751 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 644042000752 Flavoprotein; Region: Flavoprotein; pfam02441 644042000753 Predicted transcriptional regulator [Transcription]; Region: COG1959 644042000754 Transcriptional regulator; Region: Rrf2; pfam02082 644042000755 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042000756 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644042000757 manganese transport protein MntH; Reviewed; Region: PRK00701 644042000758 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 644042000759 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 644042000760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042000761 putative substrate translocation pore; other site 644042000762 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 644042000763 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 644042000764 DNA binding residues [nucleotide binding] 644042000765 putative dimer interface [polypeptide binding]; other site 644042000766 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 644042000767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644042000768 dimer interface [polypeptide binding]; other site 644042000769 phosphorylation site [posttranslational modification] 644042000770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644042000771 ATP binding site [chemical binding]; other site 644042000772 Mg2+ binding site [ion binding]; other site 644042000773 G-X-G motif; other site 644042000774 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644042000775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644042000776 active site 644042000777 phosphorylation site [posttranslational modification] 644042000778 intermolecular recognition site; other site 644042000779 dimerization interface [polypeptide binding]; other site 644042000780 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644042000781 DNA binding site [nucleotide binding] 644042000782 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 644042000783 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 644042000784 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 644042000785 putative active site [active] 644042000786 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 644042000787 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 644042000788 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 644042000789 FAD binding domain; Region: FAD_binding_4; pfam01565 644042000790 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 644042000791 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 644042000792 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 644042000793 synthetase active site [active] 644042000794 NTP binding site [chemical binding]; other site 644042000795 metal binding site [ion binding]; metal-binding site 644042000796 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 644042000797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644042000798 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 644042000799 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 644042000800 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 644042000801 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 644042000802 Cation efflux family; Region: Cation_efflux; cl00316 644042000803 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 644042000804 legume lectins; Region: lectin_L-type; cl14058 644042000805 homotetramer interaction site [polypeptide binding]; other site 644042000806 carbohydrate binding site [chemical binding]; other site 644042000807 metal binding site [ion binding]; metal-binding site 644042000808 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 644042000809 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 644042000810 FtsX-like permease family; Region: FtsX; pfam02687 644042000811 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644042000812 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 644042000813 Walker A/P-loop; other site 644042000814 ATP binding site [chemical binding]; other site 644042000815 Q-loop/lid; other site 644042000816 ABC transporter signature motif; other site 644042000817 Walker B; other site 644042000818 D-loop; other site 644042000819 H-loop/switch region; other site 644042000820 CAAX protease self-immunity; Region: Abi; pfam02517 644042000821 CAAX protease self-immunity; Region: Abi; pfam02517 644042000822 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644042000823 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 644042000824 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644042000825 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 644042000826 lipoyl attachment site [posttranslational modification]; other site 644042000827 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 644042000828 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 644042000829 DEAD_2; Region: DEAD_2; pfam06733 644042000830 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 644042000831 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 644042000832 propionate/acetate kinase; Provisional; Region: PRK12379 644042000833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644042000834 Coenzyme A binding pocket [chemical binding]; other site 644042000835 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 644042000836 MarR family; Region: MarR_2; pfam12802 644042000837 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 644042000838 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 644042000839 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644042000840 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 644042000841 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 644042000842 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 644042000843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042000844 dimer interface [polypeptide binding]; other site 644042000845 conserved gate region; other site 644042000846 putative PBP binding loops; other site 644042000847 ABC-ATPase subunit interface; other site 644042000848 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 644042000849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042000850 dimer interface [polypeptide binding]; other site 644042000851 conserved gate region; other site 644042000852 putative PBP binding loops; other site 644042000853 ABC-ATPase subunit interface; other site 644042000854 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 644042000855 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 644042000856 Walker A/P-loop; other site 644042000857 ATP binding site [chemical binding]; other site 644042000858 Q-loop/lid; other site 644042000859 ABC transporter signature motif; other site 644042000860 Walker B; other site 644042000861 D-loop; other site 644042000862 H-loop/switch region; other site 644042000863 TOBE domain; Region: TOBE_2; pfam08402 644042000864 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644042000865 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042000866 non-specific DNA binding site [nucleotide binding]; other site 644042000867 salt bridge; other site 644042000868 sequence-specific DNA binding site [nucleotide binding]; other site 644042000869 Cupin domain; Region: Cupin_2; pfam07883 644042000870 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 644042000871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644042000872 Coenzyme A binding pocket [chemical binding]; other site 644042000873 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 644042000874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644042000875 Coenzyme A binding pocket [chemical binding]; other site 644042000876 Predicted transcriptional regulators [Transcription]; Region: COG1725 644042000877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042000878 DNA-binding site [nucleotide binding]; DNA binding site 644042000879 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 644042000880 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 644042000881 Walker A/P-loop; other site 644042000882 ATP binding site [chemical binding]; other site 644042000883 Q-loop/lid; other site 644042000884 ABC transporter signature motif; other site 644042000885 Walker B; other site 644042000886 D-loop; other site 644042000887 H-loop/switch region; other site 644042000888 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 644042000889 putative catalytic cysteine [active] 644042000890 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 644042000891 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 644042000892 intersubunit interface [polypeptide binding]; other site 644042000893 active site 644042000894 zinc binding site [ion binding]; other site 644042000895 Na+ binding site [ion binding]; other site 644042000896 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 644042000897 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 644042000898 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 644042000899 HflK protein; Region: hflK; TIGR01933 644042000900 Peptidase family C69; Region: Peptidase_C69; pfam03577 644042000901 BioY family; Region: BioY; pfam02632 644042000902 Biotin operon repressor [Transcription]; Region: BirA; COG1654 644042000903 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 644042000904 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 644042000905 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 644042000906 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 644042000907 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 644042000908 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 644042000909 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 644042000910 Walker A/P-loop; other site 644042000911 ATP binding site [chemical binding]; other site 644042000912 Q-loop/lid; other site 644042000913 ABC transporter signature motif; other site 644042000914 Walker B; other site 644042000915 D-loop; other site 644042000916 H-loop/switch region; other site 644042000917 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 644042000918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042000919 dimer interface [polypeptide binding]; other site 644042000920 conserved gate region; other site 644042000921 putative PBP binding loops; other site 644042000922 ABC-ATPase subunit interface; other site 644042000923 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 644042000924 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 644042000925 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 644042000926 transaminase; Reviewed; Region: PRK08068 644042000927 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644042000928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042000929 homodimer interface [polypeptide binding]; other site 644042000930 catalytic residue [active] 644042000931 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 644042000932 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 644042000933 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 644042000934 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 644042000935 Walker A/P-loop; other site 644042000936 ATP binding site [chemical binding]; other site 644042000937 Q-loop/lid; other site 644042000938 ABC transporter signature motif; other site 644042000939 Walker B; other site 644042000940 D-loop; other site 644042000941 H-loop/switch region; other site 644042000942 type II secretion system protein F; Region: GspF; TIGR02120 644042000943 Predicted transcriptional regulators [Transcription]; Region: COG1695 644042000944 Transcriptional regulator PadR-like family; Region: PadR; cl17335 644042000945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042000946 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042000947 putative substrate translocation pore; other site 644042000948 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 644042000949 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 644042000950 tetramer (dimer of dimers) interface [polypeptide binding]; other site 644042000951 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 644042000952 NAD binding site [chemical binding]; other site 644042000953 dimer interface [polypeptide binding]; other site 644042000954 substrate binding site [chemical binding]; other site 644042000955 ATP-dependent protease Lon; Provisional; Region: PRK13765 644042000956 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 644042000957 active site 644042000958 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 644042000959 tetramer (dimer of dimers) interface [polypeptide binding]; other site 644042000960 active site 644042000961 dimer interface [polypeptide binding]; other site 644042000962 multicopper oxidase; Provisional; Region: PRK10965 644042000963 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 644042000964 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 644042000965 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 644042000966 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 644042000967 substrate binding site [chemical binding]; other site 644042000968 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 644042000969 Uncharacterized conserved protein [Function unknown]; Region: COG3410 644042000970 Transcriptional regulator; Region: Rrf2; pfam02082 644042000971 Rrf2 family protein; Region: rrf2_super; TIGR00738 644042000972 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 644042000973 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 644042000974 carboxyltransferase (CT) interaction site; other site 644042000975 biotinylation site [posttranslational modification]; other site 644042000976 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 644042000977 active site 644042000978 tetramer interface [polypeptide binding]; other site 644042000979 short chain dehydrogenase; Validated; Region: PRK06182 644042000980 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 644042000981 NADP binding site [chemical binding]; other site 644042000982 active site 644042000983 steroid binding site; other site 644042000984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042000985 dimer interface [polypeptide binding]; other site 644042000986 conserved gate region; other site 644042000987 ABC-ATPase subunit interface; other site 644042000988 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 644042000989 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 644042000990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042000991 Walker A/P-loop; other site 644042000992 ATP binding site [chemical binding]; other site 644042000993 Q-loop/lid; other site 644042000994 ABC transporter signature motif; other site 644042000995 Walker B; other site 644042000996 D-loop; other site 644042000997 H-loop/switch region; other site 644042000998 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 644042000999 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644042001000 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644042001001 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 644042001002 glycerol kinase; Provisional; Region: glpK; PRK00047 644042001003 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 644042001004 N- and C-terminal domain interface [polypeptide binding]; other site 644042001005 active site 644042001006 MgATP binding site [chemical binding]; other site 644042001007 catalytic site [active] 644042001008 metal binding site [ion binding]; metal-binding site 644042001009 glycerol binding site [chemical binding]; other site 644042001010 homotetramer interface [polypeptide binding]; other site 644042001011 homodimer interface [polypeptide binding]; other site 644042001012 FBP binding site [chemical binding]; other site 644042001013 protein IIAGlc interface [polypeptide binding]; other site 644042001014 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 644042001015 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 644042001016 amphipathic channel; other site 644042001017 Asn-Pro-Ala signature motifs; other site 644042001018 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042001019 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 644042001020 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 644042001021 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 644042001022 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 644042001023 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 644042001024 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 644042001025 active site 644042001026 substrate binding site [chemical binding]; other site 644042001027 trimer interface [polypeptide binding]; other site 644042001028 CoA binding site [chemical binding]; other site 644042001029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042001030 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042001031 putative substrate translocation pore; other site 644042001032 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 644042001033 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042001034 Cupin domain; Region: Cupin_2; pfam07883 644042001035 Helix-turn-helix domain; Region: HTH_18; pfam12833 644042001036 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 644042001037 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 644042001038 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042001039 motif II; other site 644042001040 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 644042001041 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 644042001042 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 644042001043 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 644042001044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644042001045 ATP binding site [chemical binding]; other site 644042001046 Mg2+ binding site [ion binding]; other site 644042001047 G-X-G motif; other site 644042001048 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 644042001049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644042001050 active site 644042001051 phosphorylation site [posttranslational modification] 644042001052 intermolecular recognition site; other site 644042001053 dimerization interface [polypeptide binding]; other site 644042001054 LytTr DNA-binding domain; Region: LytTR; pfam04397 644042001055 CAAX protease self-immunity; Region: Abi; pfam02517 644042001056 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 644042001057 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 644042001058 putative active site [active] 644042001059 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644042001060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042001061 Walker A/P-loop; other site 644042001062 ATP binding site [chemical binding]; other site 644042001063 Q-loop/lid; other site 644042001064 ABC transporter signature motif; other site 644042001065 Walker B; other site 644042001066 D-loop; other site 644042001067 H-loop/switch region; other site 644042001068 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 644042001069 HlyD family secretion protein; Region: HlyD_3; pfam13437 644042001070 CAAX protease self-immunity; Region: Abi; pfam02517 644042001071 CAAX protease self-immunity; Region: Abi; pfam02517 644042001072 CAAX protease self-immunity; Region: Abi; pfam02517 644042001073 CAAX protease self-immunity; Region: Abi; pfam02517 644042001074 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 644042001075 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 644042001076 sequence-specific DNA binding site [nucleotide binding]; other site 644042001077 salt bridge; other site 644042001078 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 644042001079 Part of AAA domain; Region: AAA_19; pfam13245 644042001080 Family description; Region: UvrD_C_2; pfam13538 644042001081 Predicted amidohydrolase [General function prediction only]; Region: COG0388 644042001082 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 644042001083 putative active site [active] 644042001084 catalytic triad [active] 644042001085 putative dimer interface [polypeptide binding]; other site 644042001086 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 644042001087 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 644042001088 active site 644042001089 HIGH motif; other site 644042001090 dimer interface [polypeptide binding]; other site 644042001091 KMSKS motif; other site 644042001092 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 644042001093 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042001094 DNA-binding site [nucleotide binding]; DNA binding site 644042001095 UTRA domain; Region: UTRA; pfam07702 644042001096 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 644042001097 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 644042001098 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 644042001099 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 644042001100 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 644042001101 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 644042001102 beta-galactosidase; Region: BGL; TIGR03356 644042001103 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644042001104 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 644042001105 nucleotide binding site [chemical binding]; other site 644042001106 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 644042001107 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 644042001108 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 644042001109 putative active site [active] 644042001110 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 644042001111 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 644042001112 FMN binding site [chemical binding]; other site 644042001113 active site 644042001114 catalytic residues [active] 644042001115 substrate binding site [chemical binding]; other site 644042001116 exopolyphosphatase; Region: exo_poly_only; TIGR03706 644042001117 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 644042001118 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 644042001119 homodimer interface [polypeptide binding]; other site 644042001120 catalytic residues [active] 644042001121 NAD binding site [chemical binding]; other site 644042001122 substrate binding pocket [chemical binding]; other site 644042001123 flexible flap; other site 644042001124 NAD-dependent deacetylase; Provisional; Region: PRK00481 644042001125 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 644042001126 NAD+ binding site [chemical binding]; other site 644042001127 substrate binding site [chemical binding]; other site 644042001128 putative Zn binding site [ion binding]; other site 644042001129 Protein of unknown function DUF72; Region: DUF72; pfam01904 644042001130 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 644042001131 nudix motif; other site 644042001132 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 644042001133 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 644042001134 HIGH motif; other site 644042001135 active site 644042001136 KMSKS motif; other site 644042001137 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 644042001138 tRNA binding surface [nucleotide binding]; other site 644042001139 anticodon binding site; other site 644042001140 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 644042001141 dimer interface [polypeptide binding]; other site 644042001142 putative tRNA-binding site [nucleotide binding]; other site 644042001143 potential frameshift: common BLAST hit: gi|28377355|ref|NP_784247.1| transport protein 644042001144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042001145 putative substrate translocation pore; other site 644042001146 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 644042001147 active site 644042001148 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 644042001149 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 644042001150 putative active site [active] 644042001151 putative metal binding site [ion binding]; other site 644042001152 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 644042001153 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 644042001154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644042001155 S-adenosylmethionine binding site [chemical binding]; other site 644042001156 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 644042001157 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 644042001158 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 644042001159 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 644042001160 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 644042001161 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 644042001162 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 644042001163 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 644042001164 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 644042001165 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 644042001166 putative PBP binding regions; other site 644042001167 ABC-ATPase subunit interface; other site 644042001168 pur operon repressor; Provisional; Region: PRK09213 644042001169 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 644042001170 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644042001171 active site 644042001172 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 644042001173 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 644042001174 Substrate binding site; other site 644042001175 Mg++ binding site; other site 644042001176 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 644042001177 active site 644042001178 substrate binding site [chemical binding]; other site 644042001179 CoA binding site [chemical binding]; other site 644042001180 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 644042001181 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 644042001182 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 644042001183 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644042001184 active site 644042001185 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 644042001186 putative active site [active] 644042001187 sugar phosphate phosphatase; Provisional; Region: PRK10513 644042001188 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042001189 active site 644042001190 motif I; other site 644042001191 motif II; other site 644042001192 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042001193 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 644042001194 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644042001195 Zn2+ binding site [ion binding]; other site 644042001196 Mg2+ binding site [ion binding]; other site 644042001197 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 644042001198 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 644042001199 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 644042001200 CTP synthetase; Validated; Region: pyrG; PRK05380 644042001201 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 644042001202 Catalytic site [active] 644042001203 active site 644042001204 UTP binding site [chemical binding]; other site 644042001205 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 644042001206 active site 644042001207 putative oxyanion hole; other site 644042001208 catalytic triad [active] 644042001209 seryl-tRNA synthetase; Provisional; Region: PRK05431 644042001210 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 644042001211 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 644042001212 dimer interface [polypeptide binding]; other site 644042001213 active site 644042001214 motif 1; other site 644042001215 motif 2; other site 644042001216 motif 3; other site 644042001217 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 644042001218 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 644042001219 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 644042001220 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 644042001221 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 644042001222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 644042001223 YheO-like PAS domain; Region: PAS_6; pfam08348 644042001224 HTH domain; Region: HTH_22; pfam13309 644042001225 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 644042001226 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 644042001227 hinge; other site 644042001228 active site 644042001229 transcription termination factor Rho; Provisional; Region: rho; PRK09376 644042001230 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 644042001231 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 644042001232 RNA binding site [nucleotide binding]; other site 644042001233 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 644042001234 multimer interface [polypeptide binding]; other site 644042001235 Walker A motif; other site 644042001236 ATP binding site [chemical binding]; other site 644042001237 Walker B motif; other site 644042001238 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 644042001239 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 644042001240 active site 644042001241 catalytic site [active] 644042001242 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 644042001243 heat shock protein HtpX; Provisional; Region: PRK04897 644042001244 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 644042001245 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 644042001246 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644042001247 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 644042001248 DEAD-like helicases superfamily; Region: DEXDc; smart00487 644042001249 ATP binding site [chemical binding]; other site 644042001250 Mg++ binding site [ion binding]; other site 644042001251 motif III; other site 644042001252 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644042001253 nucleotide binding region [chemical binding]; other site 644042001254 ATP-binding site [chemical binding]; other site 644042001255 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 644042001256 alanine racemase; Reviewed; Region: alr; PRK00053 644042001257 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 644042001258 active site 644042001259 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 644042001260 dimer interface [polypeptide binding]; other site 644042001261 substrate binding site [chemical binding]; other site 644042001262 catalytic residues [active] 644042001263 PemK-like protein; Region: PemK; pfam02452 644042001264 K+ potassium transporter; Region: K_trans; cl15781 644042001265 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 644042001266 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 644042001267 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 644042001268 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 644042001269 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 644042001270 ATP-grasp domain; Region: ATP-grasp_4; cl17255 644042001271 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 644042001272 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 644042001273 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 644042001274 catalytic site [active] 644042001275 subunit interface [polypeptide binding]; other site 644042001276 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 644042001277 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 644042001278 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 644042001279 heterotetramer interface [polypeptide binding]; other site 644042001280 active site pocket [active] 644042001281 cleavage site 644042001282 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 644042001283 nucleotide binding site [chemical binding]; other site 644042001284 N-acetyl-L-glutamate binding site [chemical binding]; other site 644042001285 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 644042001286 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 644042001287 inhibitor-cofactor binding pocket; inhibition site 644042001288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042001289 catalytic residue [active] 644042001290 ornithine carbamoyltransferase; Validated; Region: PRK02102 644042001291 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 644042001292 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 644042001293 QueT transporter; Region: QueT; pfam06177 644042001294 FOG: CBS domain [General function prediction only]; Region: COG0517 644042001295 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 644042001296 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 644042001297 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 644042001298 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 644042001299 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 644042001300 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 644042001301 tetramer (dimer of dimers) interface [polypeptide binding]; other site 644042001302 NAD binding site [chemical binding]; other site 644042001303 dimer interface [polypeptide binding]; other site 644042001304 substrate binding site [chemical binding]; other site 644042001305 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 644042001306 putative active site [active] 644042001307 catalytic residue [active] 644042001308 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 644042001309 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 644042001310 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644042001311 ATP binding site [chemical binding]; other site 644042001312 putative Mg++ binding site [ion binding]; other site 644042001313 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644042001314 nucleotide binding region [chemical binding]; other site 644042001315 ATP-binding site [chemical binding]; other site 644042001316 TRCF domain; Region: TRCF; pfam03461 644042001317 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 644042001318 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 644042001319 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644042001320 RNA binding surface [nucleotide binding]; other site 644042001321 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 644042001322 Septum formation initiator; Region: DivIC; pfam04977 644042001323 hypothetical protein; Provisional; Region: PRK08582 644042001324 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 644042001325 RNA binding site [nucleotide binding]; other site 644042001326 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 644042001327 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 644042001328 Ligand Binding Site [chemical binding]; other site 644042001329 TilS substrate C-terminal domain; Region: TilS_C; smart00977 644042001330 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644042001331 active site 644042001332 FtsH Extracellular; Region: FtsH_ext; pfam06480 644042001333 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 644042001334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042001335 Walker A motif; other site 644042001336 ATP binding site [chemical binding]; other site 644042001337 Walker B motif; other site 644042001338 arginine finger; other site 644042001339 Peptidase family M41; Region: Peptidase_M41; pfam01434 644042001340 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 644042001341 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 644042001342 dimerization interface [polypeptide binding]; other site 644042001343 domain crossover interface; other site 644042001344 redox-dependent activation switch; other site 644042001345 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 644042001346 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 644042001347 FMN binding site [chemical binding]; other site 644042001348 active site 644042001349 catalytic residues [active] 644042001350 substrate binding site [chemical binding]; other site 644042001351 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 644042001352 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 644042001353 dimer interface [polypeptide binding]; other site 644042001354 putative anticodon binding site; other site 644042001355 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 644042001356 motif 1; other site 644042001357 active site 644042001358 motif 2; other site 644042001359 motif 3; other site 644042001360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 644042001361 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 644042001362 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 644042001363 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 644042001364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042001365 putative substrate translocation pore; other site 644042001366 POT family; Region: PTR2; cl17359 644042001367 putative phosphoesterase; Region: acc_ester; TIGR03729 644042001368 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 644042001369 Cupin domain; Region: Cupin_2; cl17218 644042001370 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 644042001371 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 644042001372 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 644042001373 active site 644042001374 metal binding site [ion binding]; metal-binding site 644042001375 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 644042001376 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 644042001377 transmembrane helices; other site 644042001378 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 644042001379 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 644042001380 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 644042001381 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 644042001382 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 644042001383 active site 644042001384 dimer interface [polypeptide binding]; other site 644042001385 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 644042001386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042001387 DNA-binding site [nucleotide binding]; DNA binding site 644042001388 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 644042001389 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 644042001390 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 644042001391 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 644042001392 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 644042001393 active site 644042001394 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 644042001395 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 644042001396 homodimer interface [polypeptide binding]; other site 644042001397 NAD binding pocket [chemical binding]; other site 644042001398 ATP binding pocket [chemical binding]; other site 644042001399 Mg binding site [ion binding]; other site 644042001400 active-site loop [active] 644042001401 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 644042001402 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 644042001403 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644042001404 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 644042001405 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042001406 motif II; other site 644042001407 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 644042001408 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 644042001409 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 644042001410 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 644042001411 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 644042001412 RNA binding site [nucleotide binding]; other site 644042001413 hypothetical protein; Provisional; Region: PRK04351 644042001414 SprT homologues; Region: SprT; cl01182 644042001415 homoserine dehydrogenase; Provisional; Region: PRK06349 644042001416 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 644042001417 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 644042001418 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 644042001419 homoserine kinase; Provisional; Region: PRK01212 644042001420 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 644042001421 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 644042001422 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 644042001423 Int/Topo IB signature motif; other site 644042001424 T5orf172 domain; Region: T5orf172; pfam10544 644042001425 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644042001426 Ligand Binding Site [chemical binding]; other site 644042001427 Domain of unknown function (DUF955); Region: DUF955; pfam06114 644042001428 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644042001429 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042001430 non-specific DNA binding site [nucleotide binding]; other site 644042001431 salt bridge; other site 644042001432 sequence-specific DNA binding site [nucleotide binding]; other site 644042001433 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 644042001434 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 644042001435 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644042001436 putative Mg++ binding site [ion binding]; other site 644042001437 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644042001438 nucleotide binding region [chemical binding]; other site 644042001439 ATP-binding site [chemical binding]; other site 644042001440 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 644042001441 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 644042001442 polymerase nucleotide-binding site; other site 644042001443 DNA-binding residues [nucleotide binding]; DNA binding site 644042001444 nucleotide binding site [chemical binding]; other site 644042001445 primase nucleotide-binding site [nucleotide binding]; other site 644042001446 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 644042001447 Virulence-associated protein E; Region: VirE; pfam05272 644042001448 VRR-NUC domain; Region: VRR_NUC; pfam08774 644042001449 YopX protein; Region: YopX; pfam09643 644042001450 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 644042001451 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 644042001452 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 644042001453 Phage-related protein [Function unknown]; Region: COG4695; cl01923 644042001454 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 644042001455 oligomer interface [polypeptide binding]; other site 644042001456 active site residues [active] 644042001457 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 644042001458 Phage capsid family; Region: Phage_capsid; pfam05065 644042001459 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 644042001460 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 644042001461 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 644042001462 Phage tail protein; Region: Sipho_tail; cl17486 644042001463 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 644042001464 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 644042001465 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 644042001466 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 644042001467 active site 644042001468 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 644042001469 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 644042001470 putative active site [active] 644042001471 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 644042001472 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 644042001473 active pocket/dimerization site; other site 644042001474 active site 644042001475 phosphorylation site [posttranslational modification] 644042001476 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 644042001477 active site 644042001478 phosphorylation site [posttranslational modification] 644042001479 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 644042001480 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 644042001481 Domain of unknown function (DUF956); Region: DUF956; pfam06115 644042001482 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 644042001483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042001484 Walker A motif; other site 644042001485 ATP binding site [chemical binding]; other site 644042001486 Walker B motif; other site 644042001487 arginine finger; other site 644042001488 Transcriptional antiterminator [Transcription]; Region: COG3933 644042001489 PRD domain; Region: PRD; pfam00874 644042001490 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 644042001491 active pocket/dimerization site; other site 644042001492 active site 644042001493 phosphorylation site [posttranslational modification] 644042001494 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 644042001495 active pocket/dimerization site; other site 644042001496 active site 644042001497 phosphorylation site [posttranslational modification] 644042001498 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 644042001499 active site 644042001500 phosphorylation site [posttranslational modification] 644042001501 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 644042001502 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 644042001503 dimer interface [polypeptide binding]; other site 644042001504 active site 644042001505 CoA binding pocket [chemical binding]; other site 644042001506 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 644042001507 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 644042001508 carboxyltransferase (CT) interaction site; other site 644042001509 biotinylation site [posttranslational modification]; other site 644042001510 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 644042001511 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 644042001512 ATP-grasp domain; Region: ATP-grasp_4; cl17255 644042001513 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 644042001514 acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515 644042001515 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 644042001516 substrate binding site [chemical binding]; other site 644042001517 trimer interface [polypeptide binding]; other site 644042001518 oxyanion hole (OAH) forming residues; other site 644042001519 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 644042001520 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 644042001521 Membrane transport protein; Region: Mem_trans; pfam03547 644042001522 EamA-like transporter family; Region: EamA; pfam00892 644042001523 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 644042001524 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644042001525 catalytic core [active] 644042001526 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644042001527 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 644042001528 active site 644042001529 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 644042001530 trimer interface [polypeptide binding]; other site 644042001531 active site 644042001532 G bulge; other site 644042001533 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 644042001534 tetramer (dimer of dimers) interface [polypeptide binding]; other site 644042001535 active site 644042001536 dimer interface [polypeptide binding]; other site 644042001537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644042001538 Coenzyme A binding pocket [chemical binding]; other site 644042001539 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 644042001540 trimer interface [polypeptide binding]; other site 644042001541 active site 644042001542 DNA repair protein RadA; Provisional; Region: PRK11823 644042001543 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 644042001544 Walker A motif/ATP binding site; other site 644042001545 ATP binding site [chemical binding]; other site 644042001546 Walker B motif; other site 644042001547 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 644042001548 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 644042001549 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 644042001550 putative active site [active] 644042001551 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 644042001552 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 644042001553 active site 644042001554 HIGH motif; other site 644042001555 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 644042001556 active site 644042001557 KMSKS motif; other site 644042001558 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 644042001559 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 644042001560 active site 644042001561 HIGH motif; other site 644042001562 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 644042001563 KMSKS motif; other site 644042001564 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 644042001565 tRNA binding surface [nucleotide binding]; other site 644042001566 anticodon binding site; other site 644042001567 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 644042001568 active site 644042001569 metal binding site [ion binding]; metal-binding site 644042001570 dimerization interface [polypeptide binding]; other site 644042001571 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 644042001572 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 644042001573 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 644042001574 YacP-like NYN domain; Region: NYN_YacP; pfam05991 644042001575 RNA polymerase factor sigma-70; Validated; Region: PRK08295 644042001576 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644042001577 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 644042001578 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 644042001579 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 644042001580 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 644042001581 putative homodimer interface [polypeptide binding]; other site 644042001582 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 644042001583 heterodimer interface [polypeptide binding]; other site 644042001584 homodimer interface [polypeptide binding]; other site 644042001585 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 644042001586 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 644042001587 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 644042001588 23S rRNA interface [nucleotide binding]; other site 644042001589 L7/L12 interface [polypeptide binding]; other site 644042001590 putative thiostrepton binding site; other site 644042001591 L25 interface [polypeptide binding]; other site 644042001592 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 644042001593 mRNA/rRNA interface [nucleotide binding]; other site 644042001594 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 644042001595 23S rRNA interface [nucleotide binding]; other site 644042001596 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 644042001597 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 644042001598 peripheral dimer interface [polypeptide binding]; other site 644042001599 core dimer interface [polypeptide binding]; other site 644042001600 L10 interface [polypeptide binding]; other site 644042001601 L11 interface [polypeptide binding]; other site 644042001602 putative EF-Tu interaction site [polypeptide binding]; other site 644042001603 putative EF-G interaction site [polypeptide binding]; other site 644042001604 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 644042001605 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 644042001606 Predicted integral membrane protein [Function unknown]; Region: COG0392 644042001607 Uncharacterized conserved protein [Function unknown]; Region: COG2898 644042001608 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 644042001609 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644042001610 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042001611 non-specific DNA binding site [nucleotide binding]; other site 644042001612 salt bridge; other site 644042001613 sequence-specific DNA binding site [nucleotide binding]; other site 644042001614 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 644042001615 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 644042001616 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 644042001617 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 644042001618 dimer interface [polypeptide binding]; other site 644042001619 putative radical transfer pathway; other site 644042001620 diiron center [ion binding]; other site 644042001621 tyrosyl radical; other site 644042001622 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 644042001623 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 644042001624 Class I ribonucleotide reductase; Region: RNR_I; cd01679 644042001625 active site 644042001626 dimer interface [polypeptide binding]; other site 644042001627 catalytic residues [active] 644042001628 effector binding site; other site 644042001629 R2 peptide binding site; other site 644042001630 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 644042001631 catalytic residues [active] 644042001632 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 644042001633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644042001634 S-adenosylmethionine binding site [chemical binding]; other site 644042001635 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 644042001636 nucleoside/Zn binding site; other site 644042001637 dimer interface [polypeptide binding]; other site 644042001638 catalytic motif [active] 644042001639 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 644042001640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042001641 Walker A motif; other site 644042001642 ATP binding site [chemical binding]; other site 644042001643 DNA polymerase III subunit delta'; Validated; Region: PRK08485 644042001644 Walker B motif; other site 644042001645 arginine finger; other site 644042001646 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 644042001647 hypothetical protein; Validated; Region: PRK00153 644042001648 recombination protein RecR; Reviewed; Region: recR; PRK00076 644042001649 RecR protein; Region: RecR; pfam02132 644042001650 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 644042001651 putative active site [active] 644042001652 putative metal-binding site [ion binding]; other site 644042001653 tetramer interface [polypeptide binding]; other site 644042001654 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 644042001655 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 644042001656 PRD domain; Region: PRD; pfam00874 644042001657 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 644042001658 active site 644042001659 P-loop; other site 644042001660 phosphorylation site [posttranslational modification] 644042001661 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 644042001662 active site 644042001663 phosphorylation site [posttranslational modification] 644042001664 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 644042001665 active site 644042001666 phosphorylation site [posttranslational modification] 644042001667 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 644042001668 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 644042001669 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 644042001670 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 644042001671 active site 644042001672 intersubunit interface [polypeptide binding]; other site 644042001673 catalytic residue [active] 644042001674 thymidylate kinase; Validated; Region: tmk; PRK00698 644042001675 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 644042001676 TMP-binding site; other site 644042001677 ATP-binding site [chemical binding]; other site 644042001678 Protein of unknown function (DUF970); Region: DUF970; pfam06153 644042001679 DNA polymerase III subunit delta'; Validated; Region: PRK08058 644042001680 DNA polymerase III subunit delta'; Validated; Region: PRK08485 644042001681 Protein of unknown function (DUF972); Region: DUF972; pfam06156 644042001682 Predicted methyltransferases [General function prediction only]; Region: COG0313 644042001683 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 644042001684 putative SAM binding site [chemical binding]; other site 644042001685 putative homodimer interface [polypeptide binding]; other site 644042001686 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 644042001687 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 644042001688 active site 644042001689 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 644042001690 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 644042001691 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 644042001692 NAD binding site [chemical binding]; other site 644042001693 homodimer interface [polypeptide binding]; other site 644042001694 active site 644042001695 substrate binding site [chemical binding]; other site 644042001696 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 644042001697 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644042001698 catalytic residue [active] 644042001699 phosphonoacetaldehyde hydrolase; Region: phosphonatase; TIGR01422 644042001700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042001701 motif II; other site 644042001702 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 644042001703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042001704 dimer interface [polypeptide binding]; other site 644042001705 conserved gate region; other site 644042001706 ABC-ATPase subunit interface; other site 644042001707 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 644042001708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042001709 dimer interface [polypeptide binding]; other site 644042001710 conserved gate region; other site 644042001711 ABC-ATPase subunit interface; other site 644042001712 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 644042001713 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 644042001714 Walker A/P-loop; other site 644042001715 ATP binding site [chemical binding]; other site 644042001716 Q-loop/lid; other site 644042001717 ABC transporter signature motif; other site 644042001718 Walker B; other site 644042001719 D-loop; other site 644042001720 H-loop/switch region; other site 644042001721 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 644042001722 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 644042001723 Glycoprotease family; Region: Peptidase_M22; pfam00814 644042001724 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 644042001725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644042001726 Coenzyme A binding pocket [chemical binding]; other site 644042001727 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 644042001728 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644042001729 Coenzyme A binding pocket [chemical binding]; other site 644042001730 UGMP family protein; Validated; Region: PRK09604 644042001731 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 644042001732 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 644042001733 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 644042001734 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644042001735 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644042001736 ABC transporter; Region: ABC_tran_2; pfam12848 644042001737 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644042001738 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 644042001739 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 644042001740 CoA binding domain; Region: CoA_binding; pfam02629 644042001741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 644042001742 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 644042001743 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 644042001744 CAAX protease self-immunity; Region: Abi; pfam02517 644042001745 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 644042001746 oligomerisation interface [polypeptide binding]; other site 644042001747 mobile loop; other site 644042001748 roof hairpin; other site 644042001749 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 644042001750 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 644042001751 ring oligomerisation interface [polypeptide binding]; other site 644042001752 ATP/Mg binding site [chemical binding]; other site 644042001753 stacking interactions; other site 644042001754 hinge regions; other site 644042001755 Amino acid permease; Region: AA_permease_2; pfam13520 644042001756 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 644042001757 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 644042001758 Mg++ binding site [ion binding]; other site 644042001759 putative catalytic motif [active] 644042001760 substrate binding site [chemical binding]; other site 644042001761 PBP superfamily domain; Region: PBP_like_2; cl17296 644042001762 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 644042001763 Uncharacterized conserved protein [Function unknown]; Region: COG1739 644042001764 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 644042001765 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 644042001766 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 644042001767 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644042001768 ATP binding site [chemical binding]; other site 644042001769 putative Mg++ binding site [ion binding]; other site 644042001770 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644042001771 ATP-binding site [chemical binding]; other site 644042001772 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 644042001773 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644042001774 active site 644042001775 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 644042001776 30S subunit binding site; other site 644042001777 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 644042001778 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 644042001779 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 644042001780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644042001781 nucleotide binding region [chemical binding]; other site 644042001782 ATP-binding site [chemical binding]; other site 644042001783 peptide chain release factor 2; Validated; Region: prfB; PRK00578 644042001784 This domain is found in peptide chain release factors; Region: PCRF; smart00937 644042001785 RF-1 domain; Region: RF-1; pfam00472 644042001786 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 644042001787 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644042001788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644042001789 active site 644042001790 phosphorylation site [posttranslational modification] 644042001791 intermolecular recognition site; other site 644042001792 dimerization interface [polypeptide binding]; other site 644042001793 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644042001794 DNA binding site [nucleotide binding] 644042001795 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 644042001796 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644042001797 dimer interface [polypeptide binding]; other site 644042001798 phosphorylation site [posttranslational modification] 644042001799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644042001800 ATP binding site [chemical binding]; other site 644042001801 Mg2+ binding site [ion binding]; other site 644042001802 G-X-G motif; other site 644042001803 PBP superfamily domain; Region: PBP_like_2; cl17296 644042001804 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 644042001805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042001806 dimer interface [polypeptide binding]; other site 644042001807 conserved gate region; other site 644042001808 putative PBP binding loops; other site 644042001809 ABC-ATPase subunit interface; other site 644042001810 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 644042001811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042001812 putative PBP binding loops; other site 644042001813 ABC-ATPase subunit interface; other site 644042001814 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 644042001815 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 644042001816 Walker A/P-loop; other site 644042001817 ATP binding site [chemical binding]; other site 644042001818 Q-loop/lid; other site 644042001819 ABC transporter signature motif; other site 644042001820 Walker B; other site 644042001821 D-loop; other site 644042001822 H-loop/switch region; other site 644042001823 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 644042001824 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 644042001825 Walker A/P-loop; other site 644042001826 ATP binding site [chemical binding]; other site 644042001827 Q-loop/lid; other site 644042001828 ABC transporter signature motif; other site 644042001829 Walker B; other site 644042001830 D-loop; other site 644042001831 H-loop/switch region; other site 644042001832 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 644042001833 PhoU domain; Region: PhoU; pfam01895 644042001834 PhoU domain; Region: PhoU; pfam01895 644042001835 PspC domain; Region: PspC; pfam04024 644042001836 Predicted membrane protein [Function unknown]; Region: COG1950 644042001837 HPr kinase/phosphorylase; Provisional; Region: PRK05428 644042001838 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 644042001839 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 644042001840 Hpr binding site; other site 644042001841 active site 644042001842 homohexamer subunit interaction site [polypeptide binding]; other site 644042001843 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 644042001844 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 644042001845 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 644042001846 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 644042001847 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 644042001848 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 644042001849 active site 644042001850 tetramer interface; other site 644042001851 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 644042001852 potential frameshift: common BLAST hit: gi|28377618|ref|NP_784510.1| NADH oxidase 644042001853 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 644042001854 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644042001855 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 644042001856 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 644042001857 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644042001858 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644042001859 Predicted membrane protein [Function unknown]; Region: COG2323 644042001860 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 644042001861 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 644042001862 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 644042001863 active site 644042001864 substrate binding site [chemical binding]; other site 644042001865 metal binding site [ion binding]; metal-binding site 644042001866 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 644042001867 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 644042001868 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644042001869 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644042001870 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 644042001871 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 644042001872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042001873 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042001874 putative substrate translocation pore; other site 644042001875 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644042001876 Zn2+ binding site [ion binding]; other site 644042001877 Mg2+ binding site [ion binding]; other site 644042001878 excinuclease ABC subunit B; Provisional; Region: PRK05298 644042001879 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644042001880 ATP binding site [chemical binding]; other site 644042001881 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644042001882 nucleotide binding region [chemical binding]; other site 644042001883 ATP-binding site [chemical binding]; other site 644042001884 Ultra-violet resistance protein B; Region: UvrB; pfam12344 644042001885 UvrB/uvrC motif; Region: UVR; pfam02151 644042001886 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 644042001887 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 644042001888 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 644042001889 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 644042001890 S-ribosylhomocysteinase; Provisional; Region: PRK02260 644042001891 argininosuccinate synthase; Provisional; Region: PRK13820 644042001892 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 644042001893 ANP binding site [chemical binding]; other site 644042001894 Substrate Binding Site II [chemical binding]; other site 644042001895 Substrate Binding Site I [chemical binding]; other site 644042001896 argininosuccinate lyase; Provisional; Region: PRK00855 644042001897 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 644042001898 active sites [active] 644042001899 tetramer interface [polypeptide binding]; other site 644042001900 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 644042001901 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 644042001902 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 644042001903 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 644042001904 phosphate binding site [ion binding]; other site 644042001905 putative substrate binding pocket [chemical binding]; other site 644042001906 dimer interface [polypeptide binding]; other site 644042001907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 644042001908 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 644042001909 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 644042001910 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 644042001911 peptide binding site [polypeptide binding]; other site 644042001912 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 644042001913 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 644042001914 putative ligand binding site [chemical binding]; other site 644042001915 putative NAD binding site [chemical binding]; other site 644042001916 catalytic site [active] 644042001917 Clp protease; Region: CLP_protease; pfam00574 644042001918 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 644042001919 oligomer interface [polypeptide binding]; other site 644042001920 active site residues [active] 644042001921 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 644042001922 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 644042001923 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 644042001924 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 644042001925 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 644042001926 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 644042001927 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 644042001928 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 644042001929 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 644042001930 Phosphoglycerate kinase; Region: PGK; pfam00162 644042001931 substrate binding site [chemical binding]; other site 644042001932 hinge regions; other site 644042001933 ADP binding site [chemical binding]; other site 644042001934 catalytic site [active] 644042001935 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 644042001936 triosephosphate isomerase; Provisional; Region: PRK14567 644042001937 substrate binding site [chemical binding]; other site 644042001938 dimer interface [polypeptide binding]; other site 644042001939 catalytic triad [active] 644042001940 enolase; Provisional; Region: eno; PRK00077 644042001941 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 644042001942 dimer interface [polypeptide binding]; other site 644042001943 metal binding site [ion binding]; metal-binding site 644042001944 substrate binding pocket [chemical binding]; other site 644042001945 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 644042001946 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 644042001947 Cl- selectivity filter; other site 644042001948 Cl- binding residues [ion binding]; other site 644042001949 pore gating glutamate residue; other site 644042001950 dimer interface [polypeptide binding]; other site 644042001951 H+/Cl- coupling transport residue; other site 644042001952 TrkA-C domain; Region: TrkA_C; pfam02080 644042001953 protein translocase, SecG subunit; Region: secG; TIGR00810 644042001954 Esterase/lipase [General function prediction only]; Region: COG1647 644042001955 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 644042001956 ribonuclease R; Region: RNase_R; TIGR02063 644042001957 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 644042001958 RNB domain; Region: RNB; pfam00773 644042001959 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 644042001960 RNA binding site [nucleotide binding]; other site 644042001961 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 644042001962 SmpB-tmRNA interface; other site 644042001963 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 644042001964 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 644042001965 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 644042001966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 644042001967 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 644042001968 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 644042001969 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644042001970 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 644042001971 substrate binding pocket [chemical binding]; other site 644042001972 membrane-bound complex binding site; other site 644042001973 hinge residues; other site 644042001974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042001975 dimer interface [polypeptide binding]; other site 644042001976 conserved gate region; other site 644042001977 putative PBP binding loops; other site 644042001978 ABC-ATPase subunit interface; other site 644042001979 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 644042001980 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 644042001981 Walker A/P-loop; other site 644042001982 ATP binding site [chemical binding]; other site 644042001983 Q-loop/lid; other site 644042001984 ABC transporter signature motif; other site 644042001985 Walker B; other site 644042001986 D-loop; other site 644042001987 H-loop/switch region; other site 644042001988 Tubby C 2; Region: Tub_2; cl02043 644042001989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042001990 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 644042001991 active site 644042001992 motif I; other site 644042001993 motif II; other site 644042001994 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 644042001995 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 644042001996 ligand binding site [chemical binding]; other site 644042001997 active site 644042001998 UGI interface [polypeptide binding]; other site 644042001999 catalytic site [active] 644042002000 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 644042002001 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 644042002002 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 644042002003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644042002004 Coenzyme A binding pocket [chemical binding]; other site 644042002005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 644042002006 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 644042002007 active site 644042002008 catalytic site [active] 644042002009 substrate binding site [chemical binding]; other site 644042002010 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 644042002011 active site 644042002012 putative catalytic site [active] 644042002013 DNA binding site [nucleotide binding] 644042002014 putative phosphate binding site [ion binding]; other site 644042002015 metal binding site A [ion binding]; metal-binding site 644042002016 AP binding site [nucleotide binding]; other site 644042002017 metal binding site B [ion binding]; metal-binding site 644042002018 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 644042002019 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 644042002020 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 644042002021 FAD binding domain; Region: FAD_binding_4; pfam01565 644042002022 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 644042002023 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 644042002024 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 644042002025 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 644042002026 Uncharacterized conserved protein [Function unknown]; Region: COG1624 644042002027 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 644042002028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 644042002029 YbbR-like protein; Region: YbbR; pfam07949 644042002030 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 644042002031 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 644042002032 active site 644042002033 substrate binding site [chemical binding]; other site 644042002034 metal binding site [ion binding]; metal-binding site 644042002035 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 644042002036 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 644042002037 glutaminase active site [active] 644042002038 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 644042002039 dimer interface [polypeptide binding]; other site 644042002040 active site 644042002041 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 644042002042 dimer interface [polypeptide binding]; other site 644042002043 active site 644042002044 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 644042002045 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 644042002046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042002047 active site 644042002048 motif I; other site 644042002049 motif II; other site 644042002050 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 644042002051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 644042002052 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 644042002053 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 644042002054 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042002055 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 644042002056 active site 644042002057 catalytic residues [active] 644042002058 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 644042002059 dimer interface [polypeptide binding]; other site 644042002060 FMN binding site [chemical binding]; other site 644042002061 NADPH bind site [chemical binding]; other site 644042002062 H+ Antiporter protein; Region: 2A0121; TIGR00900 644042002063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042002064 putative substrate translocation pore; other site 644042002065 glycerol kinase; Provisional; Region: glpK; PRK00047 644042002066 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 644042002067 N- and C-terminal domain interface [polypeptide binding]; other site 644042002068 active site 644042002069 MgATP binding site [chemical binding]; other site 644042002070 catalytic site [active] 644042002071 metal binding site [ion binding]; metal-binding site 644042002072 glycerol binding site [chemical binding]; other site 644042002073 homotetramer interface [polypeptide binding]; other site 644042002074 homodimer interface [polypeptide binding]; other site 644042002075 FBP binding site [chemical binding]; other site 644042002076 protein IIAGlc interface [polypeptide binding]; other site 644042002077 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 644042002078 putative catalytic residues [active] 644042002079 thiol/disulfide switch; other site 644042002080 ArsC family; Region: ArsC; pfam03960 644042002081 VanZ like family; Region: VanZ; cl01971 644042002082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042002083 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042002084 putative substrate translocation pore; other site 644042002085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042002086 exopolyphosphatase; Region: exo_poly_only; TIGR03706 644042002087 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 644042002088 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 644042002089 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 644042002090 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 644042002091 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 644042002092 putative domain interface [polypeptide binding]; other site 644042002093 putative active site [active] 644042002094 catalytic site [active] 644042002095 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 644042002096 putative domain interface [polypeptide binding]; other site 644042002097 putative active site [active] 644042002098 catalytic site [active] 644042002099 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 644042002100 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644042002101 Zn2+ binding site [ion binding]; other site 644042002102 Mg2+ binding site [ion binding]; other site 644042002103 LicD family; Region: LicD; pfam04991 644042002104 Transcriptional regulators [Transcription]; Region: MarR; COG1846 644042002105 MarR family; Region: MarR_2; pfam12802 644042002106 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 644042002107 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 644042002108 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 644042002109 PYR/PP interface [polypeptide binding]; other site 644042002110 dimer interface [polypeptide binding]; other site 644042002111 tetramer interface [polypeptide binding]; other site 644042002112 TPP binding site [chemical binding]; other site 644042002113 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 644042002114 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 644042002115 TPP-binding site [chemical binding]; other site 644042002116 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 644042002117 active site 644042002118 potential frameshift: common BLAST hit: gi|28377694|ref|NP_784586.1| pyruvate oxidase 644042002119 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 644042002120 PYR/PP interface [polypeptide binding]; other site 644042002121 dimer interface [polypeptide binding]; other site 644042002122 tetramer interface [polypeptide binding]; other site 644042002123 TPP binding site [chemical binding]; other site 644042002124 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 644042002125 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 644042002126 TPP-binding site [chemical binding]; other site 644042002127 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 644042002128 recA bacterial DNA recombination protein; Region: RecA; cl17211 644042002129 TAP-like protein; Region: Abhydrolase_4; pfam08386 644042002130 Biotin operon repressor [Transcription]; Region: BirA; COG1654 644042002131 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 644042002132 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 644042002133 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 644042002134 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 644042002135 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 644042002136 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 644042002137 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 644042002138 catalytic triad [active] 644042002139 catalytic triad [active] 644042002140 oxyanion hole [active] 644042002141 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 644042002142 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 644042002143 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 644042002144 OsmC-like protein; Region: OsmC; cl00767 644042002145 amino acid transporter; Region: 2A0306; TIGR00909 644042002146 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 644042002147 AP2 domain; Region: AP2; pfam00847 644042002148 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 644042002149 substrate binding site [chemical binding]; other site 644042002150 ATP binding site [chemical binding]; other site 644042002151 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 644042002152 active site 644042002153 Ap4A binding cleft/pocket [chemical binding]; other site 644042002154 P4 phosphate binding site; other site 644042002155 nudix motif; other site 644042002156 putative P2/P3 phosphate binding site [ion binding]; other site 644042002157 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 644042002158 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 644042002159 catalytic site [active] 644042002160 G-X2-G-X-G-K; other site 644042002161 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 644042002162 metal binding site 2 [ion binding]; metal-binding site 644042002163 putative DNA binding helix; other site 644042002164 metal binding site 1 [ion binding]; metal-binding site 644042002165 dimer interface [polypeptide binding]; other site 644042002166 structural Zn2+ binding site [ion binding]; other site 644042002167 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 644042002168 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042002169 motif II; other site 644042002170 aromatic amino acid aminotransferase; Validated; Region: PRK07309 644042002171 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644042002172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042002173 homodimer interface [polypeptide binding]; other site 644042002174 catalytic residue [active] 644042002175 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 644042002176 D-lactate dehydrogenase; Validated; Region: PRK08605 644042002177 homodimer interface [polypeptide binding]; other site 644042002178 ligand binding site [chemical binding]; other site 644042002179 NAD binding site [chemical binding]; other site 644042002180 catalytic site [active] 644042002181 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 644042002182 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 644042002183 Walker A/P-loop; other site 644042002184 ATP binding site [chemical binding]; other site 644042002185 Q-loop/lid; other site 644042002186 ABC transporter signature motif; other site 644042002187 Walker B; other site 644042002188 D-loop; other site 644042002189 H-loop/switch region; other site 644042002190 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 644042002191 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644042002192 substrate binding pocket [chemical binding]; other site 644042002193 membrane-bound complex binding site; other site 644042002194 hinge residues; other site 644042002195 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 644042002196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042002197 dimer interface [polypeptide binding]; other site 644042002198 conserved gate region; other site 644042002199 putative PBP binding loops; other site 644042002200 ABC-ATPase subunit interface; other site 644042002201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042002202 dimer interface [polypeptide binding]; other site 644042002203 conserved gate region; other site 644042002204 putative PBP binding loops; other site 644042002205 ABC-ATPase subunit interface; other site 644042002206 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 644042002207 HPr interaction site; other site 644042002208 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644042002209 active site 644042002210 phosphorylation site [posttranslational modification] 644042002211 CAT RNA binding domain; Region: CAT_RBD; smart01061 644042002212 transcriptional antiterminator BglG; Provisional; Region: PRK09772 644042002213 PRD domain; Region: PRD; pfam00874 644042002214 PRD domain; Region: PRD; pfam00874 644042002215 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 644042002216 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644042002217 active site turn [active] 644042002218 phosphorylation site [posttranslational modification] 644042002219 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644042002220 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 644042002221 putative active site [active] 644042002222 YdjC motif; other site 644042002223 Mg binding site [ion binding]; other site 644042002224 putative homodimer interface [polypeptide binding]; other site 644042002225 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 644042002226 Transcriptional regulators [Transcription]; Region: MarR; COG1846 644042002227 MarR family; Region: MarR; pfam01047 644042002228 Transcriptional regulators [Transcription]; Region: MarR; COG1846 644042002229 MarR family; Region: MarR_2; pfam12802 644042002230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042002231 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042002232 putative substrate translocation pore; other site 644042002233 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 644042002234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042002235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644042002236 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 644042002237 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 644042002238 HflX GTPase family; Region: HflX; cd01878 644042002239 G1 box; other site 644042002240 GTP/Mg2+ binding site [chemical binding]; other site 644042002241 Switch I region; other site 644042002242 G2 box; other site 644042002243 G3 box; other site 644042002244 Switch II region; other site 644042002245 G4 box; other site 644042002246 G5 box; other site 644042002247 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 644042002248 nudix motif; other site 644042002249 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 644042002250 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644042002251 catalytic core [active] 644042002252 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644042002253 catalytic core [active] 644042002254 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 644042002255 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 644042002256 TrkA-N domain; Region: TrkA_N; pfam02254 644042002257 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 644042002258 TrkA-C domain; Region: TrkA_C; pfam02080 644042002259 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 644042002260 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 644042002261 putative active site [active] 644042002262 nucleotide binding site [chemical binding]; other site 644042002263 nudix motif; other site 644042002264 putative metal binding site [ion binding]; other site 644042002265 transcriptional antiterminator BglG; Provisional; Region: PRK09772 644042002266 CAT RNA binding domain; Region: CAT_RBD; smart01061 644042002267 PRD domain; Region: PRD; pfam00874 644042002268 PRD domain; Region: PRD; pfam00874 644042002269 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 644042002270 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644042002271 active site turn [active] 644042002272 phosphorylation site [posttranslational modification] 644042002273 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644042002274 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 644042002275 HPr interaction site; other site 644042002276 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644042002277 active site 644042002278 phosphorylation site [posttranslational modification] 644042002279 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 644042002280 beta-galactosidase; Region: BGL; TIGR03356 644042002281 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 644042002282 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 644042002283 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 644042002284 Part of AAA domain; Region: AAA_19; pfam13245 644042002285 Family description; Region: UvrD_C_2; pfam13538 644042002286 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 644042002287 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 644042002288 FMN binding site [chemical binding]; other site 644042002289 substrate binding site [chemical binding]; other site 644042002290 putative catalytic residue [active] 644042002291 pantothenate kinase; Provisional; Region: PRK05439 644042002292 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 644042002293 ATP-binding site [chemical binding]; other site 644042002294 CoA-binding site [chemical binding]; other site 644042002295 Mg2+-binding site [ion binding]; other site 644042002296 GMP synthase; Reviewed; Region: guaA; PRK00074 644042002297 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 644042002298 AMP/PPi binding site [chemical binding]; other site 644042002299 candidate oxyanion hole; other site 644042002300 catalytic triad [active] 644042002301 potential glutamine specificity residues [chemical binding]; other site 644042002302 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 644042002303 ATP Binding subdomain [chemical binding]; other site 644042002304 Dimerization subdomain; other site 644042002305 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644042002306 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042002307 non-specific DNA binding site [nucleotide binding]; other site 644042002308 salt bridge; other site 644042002309 sequence-specific DNA binding site [nucleotide binding]; other site 644042002310 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 644042002311 AAA domain; Region: AAA_12; pfam13087 644042002312 CAAX protease self-immunity; Region: Abi; pfam02517 644042002313 Predicted transcriptional regulators [Transcription]; Region: COG1733 644042002314 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 644042002315 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 644042002316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042002317 putative substrate translocation pore; other site 644042002318 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 644042002319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 644042002320 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 644042002321 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 644042002322 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 644042002323 catalytic triad [active] 644042002324 catalytic triad [active] 644042002325 oxyanion hole [active] 644042002326 Predicted membrane protein [Function unknown]; Region: COG2261 644042002327 Asp23 family; Region: Asp23; pfam03780 644042002328 Asp23 family; Region: Asp23; pfam03780 644042002329 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 644042002330 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 644042002331 Peptidase family M1; Region: Peptidase_M1; pfam01433 644042002332 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 644042002333 Zn binding site [ion binding]; other site 644042002334 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 644042002335 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 644042002336 GIY-YIG motif/motif A; other site 644042002337 putative active site [active] 644042002338 putative metal binding site [ion binding]; other site 644042002339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 644042002340 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 644042002341 Uncharacterized conserved protein [Function unknown]; Region: COG3410 644042002342 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 644042002343 homodimer interface [polypeptide binding]; other site 644042002344 chemical substrate binding site [chemical binding]; other site 644042002345 oligomer interface [polypeptide binding]; other site 644042002346 metal binding site [ion binding]; metal-binding site 644042002347 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644042002348 catalytic core [active] 644042002349 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 644042002350 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042002351 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042002352 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042002353 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042002354 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042002355 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042002356 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042002357 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042002358 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042002359 hypothetical protein; Provisional; Region: PRK06762 644042002360 AAA domain; Region: AAA_33; pfam13671 644042002361 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644042002362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042002363 non-specific DNA binding site [nucleotide binding]; other site 644042002364 salt bridge; other site 644042002365 sequence-specific DNA binding site [nucleotide binding]; other site 644042002366 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644042002367 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042002368 non-specific DNA binding site [nucleotide binding]; other site 644042002369 salt bridge; other site 644042002370 sequence-specific DNA binding site [nucleotide binding]; other site 644042002371 Enterocin A Immunity; Region: EntA_Immun; pfam08951 644042002372 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042002373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042002374 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 644042002375 dimerization interface [polypeptide binding]; other site 644042002376 FAD binding domain; Region: FAD_binding_2; pfam00890 644042002377 Predicted oxidoreductase [General function prediction only]; Region: COG3573 644042002378 FMN-binding domain; Region: FMN_bind; cl01081 644042002379 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 644042002380 MarR family; Region: MarR_2; cl17246 644042002381 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 644042002382 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 644042002383 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 644042002384 putative dimer interface [polypeptide binding]; other site 644042002385 putative anticodon binding site; other site 644042002386 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 644042002387 homodimer interface [polypeptide binding]; other site 644042002388 motif 1; other site 644042002389 motif 2; other site 644042002390 active site 644042002391 motif 3; other site 644042002392 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 644042002393 dimer interface [polypeptide binding]; other site 644042002394 active site 644042002395 Peptidase family C69; Region: Peptidase_C69; pfam03577 644042002396 Helix-turn-helix domain; Region: HTH_28; pfam13518 644042002397 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 644042002398 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644042002399 ATP binding site [chemical binding]; other site 644042002400 putative Mg++ binding site [ion binding]; other site 644042002401 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644042002402 nucleotide binding region [chemical binding]; other site 644042002403 ATP-binding site [chemical binding]; other site 644042002404 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 644042002405 HRDC domain; Region: HRDC; pfam00570 644042002406 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 644042002407 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 644042002408 active site 644042002409 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644042002410 dimerization interface [polypeptide binding]; other site 644042002411 putative DNA binding site [nucleotide binding]; other site 644042002412 putative Zn2+ binding site [ion binding]; other site 644042002413 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 644042002414 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 644042002415 YibE/F-like protein; Region: YibE_F; pfam07907 644042002416 YibE/F-like protein; Region: YibE_F; pfam07907 644042002417 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 644042002418 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644042002419 Coenzyme A binding pocket [chemical binding]; other site 644042002420 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644042002421 catalytic core [active] 644042002422 Enterocin A Immunity; Region: EntA_Immun; pfam08951 644042002423 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 644042002424 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 644042002425 potential frameshift: common BLAST hit: gi|28377794|ref|NP_784686.1| sugar transport protein 644042002426 MFS/sugar transport protein; Region: MFS_2; pfam13347 644042002427 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 644042002428 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 644042002429 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 644042002430 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 644042002431 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644042002432 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644042002433 aspartate kinase I; Reviewed; Region: PRK08210 644042002434 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 644042002435 putative catalytic residues [active] 644042002436 putative nucleotide binding site [chemical binding]; other site 644042002437 putative aspartate binding site [chemical binding]; other site 644042002438 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 644042002439 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 644042002440 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 644042002441 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 644042002442 active site 644042002443 dimer interface [polypeptide binding]; other site 644042002444 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 644042002445 Ligand Binding Site [chemical binding]; other site 644042002446 Molecular Tunnel; other site 644042002447 Predicted membrane protein [Function unknown]; Region: COG4392 644042002448 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 644042002449 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 644042002450 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 644042002451 DNA binding residues [nucleotide binding] 644042002452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042002453 putative substrate translocation pore; other site 644042002454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042002455 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 644042002456 DNA binding residues [nucleotide binding] 644042002457 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 644042002458 putative dimer interface [polypeptide binding]; other site 644042002459 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 644042002460 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 644042002461 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 644042002462 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 644042002463 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 644042002464 DNA-binding site [nucleotide binding]; DNA binding site 644042002465 RNA-binding motif; other site 644042002466 Uncharacterized conserved protein [Function unknown]; Region: COG2966 644042002467 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 644042002468 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 644042002469 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 644042002470 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 644042002471 active site 644042002472 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 644042002473 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 644042002474 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 644042002475 Predicted transcriptional regulator [Transcription]; Region: COG1959 644042002476 Transcriptional regulator; Region: Rrf2; pfam02082 644042002477 acetolactate synthase; Reviewed; Region: PRK08617 644042002478 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 644042002479 PYR/PP interface [polypeptide binding]; other site 644042002480 dimer interface [polypeptide binding]; other site 644042002481 TPP binding site [chemical binding]; other site 644042002482 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 644042002483 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 644042002484 TPP-binding site [chemical binding]; other site 644042002485 dimer interface [polypeptide binding]; other site 644042002486 lysine transporter; Provisional; Region: PRK10836 644042002487 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 644042002488 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 644042002489 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 644042002490 Substrate-binding site [chemical binding]; other site 644042002491 Substrate specificity [chemical binding]; other site 644042002492 seryl-tRNA synthetase; Provisional; Region: PRK05431 644042002493 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 644042002494 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 644042002495 dimer interface [polypeptide binding]; other site 644042002496 active site 644042002497 motif 1; other site 644042002498 motif 2; other site 644042002499 motif 3; other site 644042002500 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 644042002501 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 644042002502 Clp amino terminal domain; Region: Clp_N; pfam02861 644042002503 Clp amino terminal domain; Region: Clp_N; pfam02861 644042002504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042002505 Walker A motif; other site 644042002506 ATP binding site [chemical binding]; other site 644042002507 Walker B motif; other site 644042002508 arginine finger; other site 644042002509 UvrB/uvrC motif; Region: UVR; pfam02151 644042002510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042002511 Walker A motif; other site 644042002512 ATP binding site [chemical binding]; other site 644042002513 Walker B motif; other site 644042002514 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 644042002515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042002516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644042002517 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 644042002518 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 644042002519 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 644042002520 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 644042002521 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 644042002522 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 644042002523 RPB1 interaction site [polypeptide binding]; other site 644042002524 RPB10 interaction site [polypeptide binding]; other site 644042002525 RPB11 interaction site [polypeptide binding]; other site 644042002526 RPB3 interaction site [polypeptide binding]; other site 644042002527 RPB12 interaction site [polypeptide binding]; other site 644042002528 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 644042002529 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 644042002530 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 644042002531 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 644042002532 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 644042002533 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 644042002534 cleft; other site 644042002535 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 644042002536 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 644042002537 DNA binding site [nucleotide binding] 644042002538 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 644042002539 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 644042002540 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 644042002541 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 644042002542 S17 interaction site [polypeptide binding]; other site 644042002543 S8 interaction site; other site 644042002544 16S rRNA interaction site [nucleotide binding]; other site 644042002545 streptomycin interaction site [chemical binding]; other site 644042002546 23S rRNA interaction site [nucleotide binding]; other site 644042002547 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 644042002548 30S ribosomal protein S7; Validated; Region: PRK05302 644042002549 elongation factor G; Reviewed; Region: PRK12739 644042002550 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 644042002551 G1 box; other site 644042002552 putative GEF interaction site [polypeptide binding]; other site 644042002553 GTP/Mg2+ binding site [chemical binding]; other site 644042002554 Switch I region; other site 644042002555 G2 box; other site 644042002556 G3 box; other site 644042002557 Switch II region; other site 644042002558 G4 box; other site 644042002559 G5 box; other site 644042002560 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 644042002561 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 644042002562 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 644042002563 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 644042002564 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 644042002565 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 644042002566 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 644042002567 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 644042002568 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 644042002569 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 644042002570 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 644042002571 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 644042002572 putative translocon binding site; other site 644042002573 protein-rRNA interface [nucleotide binding]; other site 644042002574 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 644042002575 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 644042002576 G-X-X-G motif; other site 644042002577 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 644042002578 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 644042002579 23S rRNA interface [nucleotide binding]; other site 644042002580 5S rRNA interface [nucleotide binding]; other site 644042002581 putative antibiotic binding site [chemical binding]; other site 644042002582 L25 interface [polypeptide binding]; other site 644042002583 L27 interface [polypeptide binding]; other site 644042002584 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 644042002585 23S rRNA interface [nucleotide binding]; other site 644042002586 putative translocon interaction site; other site 644042002587 signal recognition particle (SRP54) interaction site; other site 644042002588 L23 interface [polypeptide binding]; other site 644042002589 trigger factor interaction site; other site 644042002590 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 644042002591 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 644042002592 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 644042002593 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 644042002594 RNA binding site [nucleotide binding]; other site 644042002595 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 644042002596 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 644042002597 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 644042002598 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 644042002599 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 644042002600 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 644042002601 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 644042002602 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 644042002603 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 644042002604 5S rRNA interface [nucleotide binding]; other site 644042002605 L27 interface [polypeptide binding]; other site 644042002606 23S rRNA interface [nucleotide binding]; other site 644042002607 L5 interface [polypeptide binding]; other site 644042002608 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 644042002609 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 644042002610 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 644042002611 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 644042002612 23S rRNA binding site [nucleotide binding]; other site 644042002613 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 644042002614 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 644042002615 SecY translocase; Region: SecY; pfam00344 644042002616 adenylate kinase; Reviewed; Region: adk; PRK00279 644042002617 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 644042002618 AMP-binding site [chemical binding]; other site 644042002619 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 644042002620 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 644042002621 rRNA binding site [nucleotide binding]; other site 644042002622 predicted 30S ribosome binding site; other site 644042002623 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 644042002624 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 644042002625 30S ribosomal protein S13; Region: bact_S13; TIGR03631 644042002626 30S ribosomal protein S11; Validated; Region: PRK05309 644042002627 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 644042002628 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 644042002629 alphaNTD homodimer interface [polypeptide binding]; other site 644042002630 alphaNTD - beta interaction site [polypeptide binding]; other site 644042002631 alphaNTD - beta' interaction site [polypeptide binding]; other site 644042002632 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 644042002633 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 644042002634 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 644042002635 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 644042002636 substrate binding pocket [chemical binding]; other site 644042002637 chain length determination region; other site 644042002638 substrate-Mg2+ binding site; other site 644042002639 catalytic residues [active] 644042002640 aspartate-rich region 1; other site 644042002641 active site lid residues [active] 644042002642 aspartate-rich region 2; other site 644042002643 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 644042002644 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 644042002645 trimer interface [polypeptide binding]; other site 644042002646 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 644042002647 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644042002648 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 644042002649 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 644042002650 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 644042002651 ApbE family; Region: ApbE; pfam02424 644042002652 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 644042002653 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 644042002654 Walker A/P-loop; other site 644042002655 ATP binding site [chemical binding]; other site 644042002656 Q-loop/lid; other site 644042002657 ABC transporter signature motif; other site 644042002658 Walker B; other site 644042002659 D-loop; other site 644042002660 H-loop/switch region; other site 644042002661 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 644042002662 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 644042002663 Walker A/P-loop; other site 644042002664 ATP binding site [chemical binding]; other site 644042002665 Q-loop/lid; other site 644042002666 ABC transporter signature motif; other site 644042002667 Walker B; other site 644042002668 D-loop; other site 644042002669 H-loop/switch region; other site 644042002670 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 644042002671 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 644042002672 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 644042002673 dimerization interface 3.5A [polypeptide binding]; other site 644042002674 active site 644042002675 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 644042002676 23S rRNA interface [nucleotide binding]; other site 644042002677 L3 interface [polypeptide binding]; other site 644042002678 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 644042002679 EDD domain protein, DegV family; Region: DegV; TIGR00762 644042002680 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 644042002681 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 644042002682 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 644042002683 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 644042002684 TPP-binding site [chemical binding]; other site 644042002685 dimer interface [polypeptide binding]; other site 644042002686 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 644042002687 PYR/PP interface [polypeptide binding]; other site 644042002688 dimer interface [polypeptide binding]; other site 644042002689 TPP binding site [chemical binding]; other site 644042002690 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 644042002691 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 644042002692 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 644042002693 shikimate binding site; other site 644042002694 NAD(P) binding site [chemical binding]; other site 644042002695 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 644042002696 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 644042002697 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 644042002698 active site 644042002699 dimer interface [polypeptide binding]; other site 644042002700 metal binding site [ion binding]; metal-binding site 644042002701 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 644042002702 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 644042002703 transmembrane helices; other site 644042002704 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 644042002705 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 644042002706 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 644042002707 Cupin domain; Region: Cupin_2; pfam07883 644042002708 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 644042002709 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 644042002710 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 644042002711 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 644042002712 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 644042002713 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644042002714 ABC-ATPase subunit interface; other site 644042002715 dimer interface [polypeptide binding]; other site 644042002716 putative PBP binding regions; other site 644042002717 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 644042002718 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 644042002719 metal binding site [ion binding]; metal-binding site 644042002720 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 644042002721 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 644042002722 tetramer (dimer of dimers) interface [polypeptide binding]; other site 644042002723 NAD binding site [chemical binding]; other site 644042002724 dimer interface [polypeptide binding]; other site 644042002725 substrate binding site [chemical binding]; other site 644042002726 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 644042002727 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 644042002728 transmembrane helices; other site 644042002729 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 644042002730 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 644042002731 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 644042002732 Malic enzyme, N-terminal domain; Region: malic; pfam00390 644042002733 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 644042002734 NAD(P) binding pocket [chemical binding]; other site 644042002735 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 644042002736 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 644042002737 putative active site [active] 644042002738 (T/H)XGH motif; other site 644042002739 citrate lyase subunit gamma; Provisional; Region: PRK13253 644042002740 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 644042002741 citrate lyase, alpha subunit; Region: citF; TIGR01584 644042002742 fumarate hydratase; Reviewed; Region: fumC; PRK00485 644042002743 Class II fumarases; Region: Fumarase_classII; cd01362 644042002744 active site 644042002745 tetramer interface [polypeptide binding]; other site 644042002746 L-aspartate oxidase; Provisional; Region: PRK06175 644042002747 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 644042002748 L-aspartate oxidase; Provisional; Region: PRK06175 644042002749 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 644042002750 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042002751 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042002752 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644042002753 dimerization interface [polypeptide binding]; other site 644042002754 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042002755 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042002756 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644042002757 dimerization interface [polypeptide binding]; other site 644042002758 malate dehydrogenase; Provisional; Region: PRK13529 644042002759 Malic enzyme, N-terminal domain; Region: malic; pfam00390 644042002760 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 644042002761 NAD(P) binding site [chemical binding]; other site 644042002762 Membrane transport protein; Region: Mem_trans; cl09117 644042002763 amino acid transporter; Region: 2A0306; TIGR00909 644042002764 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 644042002765 Predicted membrane protein [Function unknown]; Region: COG4684 644042002766 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 644042002767 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 644042002768 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 644042002769 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 644042002770 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 644042002771 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 644042002772 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 644042002773 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644042002774 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 644042002775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042002776 Walker A/P-loop; other site 644042002777 ATP binding site [chemical binding]; other site 644042002778 Q-loop/lid; other site 644042002779 ABC transporter signature motif; other site 644042002780 Walker B; other site 644042002781 D-loop; other site 644042002782 H-loop/switch region; other site 644042002783 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 644042002784 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644042002785 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 644042002786 Walker A/P-loop; other site 644042002787 ATP binding site [chemical binding]; other site 644042002788 Q-loop/lid; other site 644042002789 ABC transporter signature motif; other site 644042002790 Walker B; other site 644042002791 D-loop; other site 644042002792 H-loop/switch region; other site 644042002793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 644042002794 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 644042002795 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 644042002796 substrate binding pocket [chemical binding]; other site 644042002797 chain length determination region; other site 644042002798 substrate-Mg2+ binding site; other site 644042002799 catalytic residues [active] 644042002800 aspartate-rich region 1; other site 644042002801 active site lid residues [active] 644042002802 aspartate-rich region 2; other site 644042002803 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 644042002804 UbiA prenyltransferase family; Region: UbiA; pfam01040 644042002805 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 644042002806 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 644042002807 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 644042002808 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644042002809 active site 644042002810 hypothetical protein; Provisional; Region: PRK04164 644042002811 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 644042002812 ATP-grasp domain; Region: ATP-grasp_4; cl17255 644042002813 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 644042002814 Part of AAA domain; Region: AAA_19; pfam13245 644042002815 Family description; Region: UvrD_C_2; pfam13538 644042002816 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 644042002817 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 644042002818 nucleotide binding pocket [chemical binding]; other site 644042002819 K-X-D-G motif; other site 644042002820 catalytic site [active] 644042002821 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 644042002822 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 644042002823 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 644042002824 Dimer interface [polypeptide binding]; other site 644042002825 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 644042002826 putative dimer interface [polypeptide binding]; other site 644042002827 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 644042002828 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 644042002829 putative dimer interface [polypeptide binding]; other site 644042002830 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 644042002831 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 644042002832 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 644042002833 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 644042002834 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 644042002835 GatB domain; Region: GatB_Yqey; pfam02637 644042002836 putative lipid kinase; Reviewed; Region: PRK13055 644042002837 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 644042002838 TRAM domain; Region: TRAM; pfam01938 644042002839 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 644042002840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644042002841 S-adenosylmethionine binding site [chemical binding]; other site 644042002842 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042002843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644042002844 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 644042002845 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644042002846 Soluble P-type ATPase [General function prediction only]; Region: COG4087 644042002847 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 644042002848 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 644042002849 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 644042002850 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 644042002851 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 644042002852 putative active site [active] 644042002853 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 644042002854 active site 644042002855 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 644042002856 DNA-binding site [nucleotide binding]; DNA binding site 644042002857 RNA-binding motif; other site 644042002858 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 644042002859 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 644042002860 DEAD-like helicases superfamily; Region: DEXDc; smart00487 644042002861 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 644042002862 ATP binding site [chemical binding]; other site 644042002863 putative Mg++ binding site [ion binding]; other site 644042002864 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644042002865 nucleotide binding region [chemical binding]; other site 644042002866 ATP-binding site [chemical binding]; other site 644042002867 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 644042002868 Int/Topo IB signature motif; other site 644042002869 Domain of unknown function (DUF955); Region: DUF955; pfam06114 644042002870 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644042002871 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042002872 non-specific DNA binding site [nucleotide binding]; other site 644042002873 salt bridge; other site 644042002874 sequence-specific DNA binding site [nucleotide binding]; other site 644042002875 ORF6N domain; Region: ORF6N; pfam10543 644042002876 ORF6C domain; Region: ORF6C; pfam10552 644042002877 Helix-turn-helix domain; Region: HTH_17; pfam12728 644042002878 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 644042002879 ERF superfamily; Region: ERF; pfam04404 644042002880 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 644042002881 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 644042002882 dimer interface [polypeptide binding]; other site 644042002883 ssDNA binding site [nucleotide binding]; other site 644042002884 tetramer (dimer of dimers) interface [polypeptide binding]; other site 644042002885 HNH endonuclease; Region: HNH_3; pfam13392 644042002886 Protein of unknown function (DUF968); Region: DUF968; pfam06147 644042002887 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 644042002888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042002889 Walker A motif; other site 644042002890 ATP binding site [chemical binding]; other site 644042002891 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 644042002892 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 644042002893 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 644042002894 active site 644042002895 Phage terminase, small subunit; Region: Terminase_4; pfam05119 644042002896 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 644042002897 Phage portal protein; Region: Phage_portal; pfam04860 644042002898 Phage-related protein [Function unknown]; Region: COG4695; cl01923 644042002899 Phage head maturation protease [General function prediction only]; Region: COG3740 644042002900 Phage capsid family; Region: Phage_capsid; pfam05065 644042002901 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 644042002902 Protein of unknown function (DUF806); Region: DUF806; pfam05657 644042002903 Phage major tail protein; Region: Phage_tail; pfam04630 644042002904 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 644042002905 Phage-related tail protein [Function unknown]; Region: COG5283 644042002906 NlpC/P60 family; Region: NLPC_P60; pfam00877 644042002907 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 644042002908 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 644042002909 N-acetyl-D-glucosamine binding site [chemical binding]; other site 644042002910 catalytic residue [active] 644042002911 Phage tail protein; Region: Sipho_tail; cl17486 644042002912 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 644042002913 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 644042002914 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 644042002915 active site 644042002916 Bacterial SH3 domain; Region: SH3_5; pfam08460 644042002917 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 644042002918 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644042002919 Haemolysin XhlA; Region: XhlA; pfam10779 644042002920 Bacteriophage holin; Region: Phage_holin_1; cl02344 644042002921 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644042002922 Ligand Binding Site [chemical binding]; other site 644042002923 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 644042002924 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 644042002925 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 644042002926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042002927 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 644042002928 Walker A motif; other site 644042002929 ATP binding site [chemical binding]; other site 644042002930 Walker B motif; other site 644042002931 arginine finger; other site 644042002932 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 644042002933 active site 644042002934 catalytic triad [active] 644042002935 glutamate dehydrogenase; Provisional; Region: PRK09414 644042002936 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 644042002937 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 644042002938 NAD(P) binding site [chemical binding]; other site 644042002939 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 644042002940 Beta-lactamase; Region: Beta-lactamase; pfam00144 644042002941 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 644042002942 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 644042002943 active site 644042002944 homodimer interface [polypeptide binding]; other site 644042002945 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 644042002946 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 644042002947 amphipathic channel; other site 644042002948 Asn-Pro-Ala signature motifs; other site 644042002949 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644042002950 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 644042002951 Helix-turn-helix domain; Region: HTH_28; pfam13518 644042002952 Winged helix-turn helix; Region: HTH_29; pfam13551 644042002953 Integrase core domain; Region: rve; pfam00665 644042002954 Integrase core domain; Region: rve_3; pfam13683 644042002955 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 644042002956 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 644042002957 active site 644042002958 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 644042002959 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 644042002960 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 644042002961 active site 644042002962 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 644042002963 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 644042002964 active site 644042002965 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644042002966 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 644042002967 Chain length determinant protein; Region: Wzz; cl15801 644042002968 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 644042002969 AAA domain; Region: AAA_31; pfam13614 644042002970 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 644042002971 Beta-lactamase; Region: Beta-lactamase; cl17358 644042002972 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 644042002973 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 644042002974 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 644042002975 substrate binding site; other site 644042002976 tetramer interface; other site 644042002977 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 644042002978 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 644042002979 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 644042002980 NAD binding site [chemical binding]; other site 644042002981 substrate binding site [chemical binding]; other site 644042002982 homodimer interface [polypeptide binding]; other site 644042002983 active site 644042002984 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 644042002985 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 644042002986 NADP binding site [chemical binding]; other site 644042002987 active site 644042002988 putative substrate binding site [chemical binding]; other site 644042002989 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 644042002990 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 644042002991 Int/Topo IB signature motif; other site 644042002992 legume lectins; Region: lectin_L-type; cd01951 644042002993 homotetramer interaction site [polypeptide binding]; other site 644042002994 carbohydrate binding site [chemical binding]; other site 644042002995 metal binding site [ion binding]; metal-binding site 644042002996 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042002997 MucBP domain; Region: MucBP; pfam06458 644042002998 MucBP domain; Region: MucBP; pfam06458 644042002999 MucBP domain; Region: MucBP; pfam06458 644042003000 MarR family; Region: MarR; pfam01047 644042003001 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 644042003002 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 644042003003 Bacterial sugar transferase; Region: Bac_transf; pfam02397 644042003004 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 644042003005 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 644042003006 recombination regulator RecX; Provisional; Region: recX; PRK14135 644042003007 hypothetical protein; Provisional; Region: PRK13662 644042003008 NlpC/P60 family; Region: NLPC_P60; pfam00877 644042003009 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644042003010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042003011 non-specific DNA binding site [nucleotide binding]; other site 644042003012 salt bridge; other site 644042003013 sequence-specific DNA binding site [nucleotide binding]; other site 644042003014 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 644042003015 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 644042003016 Beta-lactamase; Region: Beta-lactamase; pfam00144 644042003017 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 644042003018 tetramer (dimer of dimers) interface [polypeptide binding]; other site 644042003019 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 644042003020 NAD binding site [chemical binding]; other site 644042003021 dimer interface [polypeptide binding]; other site 644042003022 substrate binding site [chemical binding]; other site 644042003023 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 644042003024 Domain of unknown function DUF20; Region: UPF0118; pfam01594 644042003025 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 644042003026 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 644042003027 active site 644042003028 nucleotide binding site [chemical binding]; other site 644042003029 HIGH motif; other site 644042003030 KMSKS motif; other site 644042003031 fructuronate transporter; Provisional; Region: PRK10034; cl15264 644042003032 GntP family permease; Region: GntP_permease; pfam02447 644042003033 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 644042003034 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 644042003035 N- and C-terminal domain interface [polypeptide binding]; other site 644042003036 active site 644042003037 catalytic site [active] 644042003038 metal binding site [ion binding]; metal-binding site 644042003039 carbohydrate binding site [chemical binding]; other site 644042003040 ATP binding site [chemical binding]; other site 644042003041 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 644042003042 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 644042003043 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 644042003044 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644042003045 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644042003046 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 644042003047 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 644042003048 G1 box; other site 644042003049 putative GEF interaction site [polypeptide binding]; other site 644042003050 GTP/Mg2+ binding site [chemical binding]; other site 644042003051 Switch I region; other site 644042003052 G2 box; other site 644042003053 G3 box; other site 644042003054 Switch II region; other site 644042003055 G4 box; other site 644042003056 G5 box; other site 644042003057 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 644042003058 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042003059 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042003060 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042003061 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042003062 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 644042003063 dimerization interface [polypeptide binding]; other site 644042003064 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 644042003065 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 644042003066 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 644042003067 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 644042003068 peptide binding site [polypeptide binding]; other site 644042003069 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 644042003070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042003071 dimer interface [polypeptide binding]; other site 644042003072 conserved gate region; other site 644042003073 putative PBP binding loops; other site 644042003074 ABC-ATPase subunit interface; other site 644042003075 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 644042003076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042003077 dimer interface [polypeptide binding]; other site 644042003078 conserved gate region; other site 644042003079 putative PBP binding loops; other site 644042003080 ABC-ATPase subunit interface; other site 644042003081 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 644042003082 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644042003083 Walker A/P-loop; other site 644042003084 ATP binding site [chemical binding]; other site 644042003085 Q-loop/lid; other site 644042003086 ABC transporter signature motif; other site 644042003087 Walker B; other site 644042003088 D-loop; other site 644042003089 H-loop/switch region; other site 644042003090 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644042003091 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 644042003092 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644042003093 Walker A/P-loop; other site 644042003094 ATP binding site [chemical binding]; other site 644042003095 Q-loop/lid; other site 644042003096 ABC transporter signature motif; other site 644042003097 Walker B; other site 644042003098 D-loop; other site 644042003099 H-loop/switch region; other site 644042003100 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644042003101 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 644042003102 MarR family; Region: MarR_2; pfam12802 644042003103 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 644042003104 Int/Topo IB signature motif; other site 644042003105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042003106 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 644042003107 Walker A motif; other site 644042003108 ATP binding site [chemical binding]; other site 644042003109 Walker B motif; other site 644042003110 arginine finger; other site 644042003111 UvrB/uvrC motif; Region: UVR; pfam02151 644042003112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042003113 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 644042003114 Walker A motif; other site 644042003115 ATP binding site [chemical binding]; other site 644042003116 Walker B motif; other site 644042003117 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 644042003118 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 644042003119 dimerization domain swap beta strand [polypeptide binding]; other site 644042003120 regulatory protein interface [polypeptide binding]; other site 644042003121 active site 644042003122 regulatory phosphorylation site [posttranslational modification]; other site 644042003123 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 644042003124 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 644042003125 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 644042003126 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 644042003127 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644042003128 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 644042003129 putative ADP-binding pocket [chemical binding]; other site 644042003130 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 644042003131 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644042003132 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 644042003133 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 644042003134 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 644042003135 aromatic amino acid aminotransferase; Validated; Region: PRK07309 644042003136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644042003137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042003138 homodimer interface [polypeptide binding]; other site 644042003139 catalytic residue [active] 644042003140 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 644042003141 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 644042003142 Sulfatase; Region: Sulfatase; pfam00884 644042003143 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644042003144 active site 644042003145 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 644042003146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644042003147 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 644042003148 Coenzyme A binding pocket [chemical binding]; other site 644042003149 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 644042003150 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 644042003151 active site 644042003152 metal binding site [ion binding]; metal-binding site 644042003153 Cupin domain; Region: Cupin_2; cl17218 644042003154 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 644042003155 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 644042003156 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 644042003157 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042003158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042003159 putative substrate translocation pore; other site 644042003160 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644042003161 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 644042003162 nucleotide binding site [chemical binding]; other site 644042003163 butyrate kinase; Region: butyr_kinase; TIGR02707 644042003164 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 644042003165 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 644042003166 Ferrochelatase; Region: Ferrochelatase; pfam00762 644042003167 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 644042003168 C-terminal domain interface [polypeptide binding]; other site 644042003169 active site 644042003170 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 644042003171 active site 644042003172 N-terminal domain interface [polypeptide binding]; other site 644042003173 S-methylmethionine transporter; Provisional; Region: PRK11387 644042003174 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 644042003175 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 644042003176 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 644042003177 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 644042003178 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 644042003179 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644042003180 S-adenosylmethionine synthetase; Validated; Region: PRK05250 644042003181 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 644042003182 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 644042003183 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 644042003184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042003185 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042003186 putative substrate translocation pore; other site 644042003187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042003188 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 644042003189 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 644042003190 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644042003191 potential frameshift: common BLAST hit: gi|28378062|ref|NP_784954.1| poly(glycerol-phosphate) alpha-glucosyltransferase 644042003192 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 644042003193 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 644042003194 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644042003195 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 644042003196 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644042003197 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 644042003198 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 644042003199 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 644042003200 active site 644042003201 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 644042003202 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 644042003203 HIGH motif; other site 644042003204 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 644042003205 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 644042003206 active site 644042003207 KMSKS motif; other site 644042003208 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 644042003209 tRNA binding surface [nucleotide binding]; other site 644042003210 stage V sporulation protein B; Region: spore_V_B; TIGR02900 644042003211 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 644042003212 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 644042003213 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644042003214 RNA binding surface [nucleotide binding]; other site 644042003215 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 644042003216 active site 644042003217 uracil binding [chemical binding]; other site 644042003218 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 644042003219 putative substrate binding site [chemical binding]; other site 644042003220 putative ATP binding site [chemical binding]; other site 644042003221 dipeptidase PepV; Reviewed; Region: PRK07318 644042003222 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 644042003223 active site 644042003224 metal binding site [ion binding]; metal-binding site 644042003225 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644042003226 Ligand Binding Site [chemical binding]; other site 644042003227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 644042003228 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 644042003229 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 644042003230 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 644042003231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042003232 Walker A/P-loop; other site 644042003233 ATP binding site [chemical binding]; other site 644042003234 Q-loop/lid; other site 644042003235 ABC transporter signature motif; other site 644042003236 Walker B; other site 644042003237 D-loop; other site 644042003238 H-loop/switch region; other site 644042003239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042003240 dimer interface [polypeptide binding]; other site 644042003241 conserved gate region; other site 644042003242 putative PBP binding loops; other site 644042003243 ABC-ATPase subunit interface; other site 644042003244 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 644042003245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042003246 dimer interface [polypeptide binding]; other site 644042003247 conserved gate region; other site 644042003248 putative PBP binding loops; other site 644042003249 ABC-ATPase subunit interface; other site 644042003250 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 644042003251 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 644042003252 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 644042003253 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 644042003254 active site 644042003255 catalytic site [active] 644042003256 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 644042003257 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 644042003258 Substrate-binding site [chemical binding]; other site 644042003259 Substrate specificity [chemical binding]; other site 644042003260 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 644042003261 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 644042003262 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 644042003263 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 644042003264 Predicted membrane protein [Function unknown]; Region: COG1511 644042003265 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 644042003266 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 644042003267 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 644042003268 Walker A/P-loop; other site 644042003269 ATP binding site [chemical binding]; other site 644042003270 Q-loop/lid; other site 644042003271 ABC transporter signature motif; other site 644042003272 Walker B; other site 644042003273 D-loop; other site 644042003274 H-loop/switch region; other site 644042003275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042003276 Walker A/P-loop; other site 644042003277 ATP binding site [chemical binding]; other site 644042003278 ABC transporter; Region: ABC_tran; pfam00005 644042003279 Q-loop/lid; other site 644042003280 ABC transporter signature motif; other site 644042003281 Walker B; other site 644042003282 D-loop; other site 644042003283 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 644042003284 H-loop/switch region; other site 644042003285 LytTr DNA-binding domain; Region: LytTR; pfam04397 644042003286 Enterocin A Immunity; Region: EntA_Immun; pfam08951 644042003287 methionine sulfoxide reductase A; Provisional; Region: PRK14054 644042003288 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 644042003289 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 644042003290 DNA binding residues [nucleotide binding] 644042003291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644042003292 NADH(P)-binding; Region: NAD_binding_10; pfam13460 644042003293 NAD(P) binding site [chemical binding]; other site 644042003294 active site 644042003295 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 644042003296 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 644042003297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 644042003298 active site 644042003299 motif I; other site 644042003300 motif II; other site 644042003301 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 644042003302 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 644042003303 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 644042003304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644042003305 active site 644042003306 phosphorylation site [posttranslational modification] 644042003307 intermolecular recognition site; other site 644042003308 dimerization interface [polypeptide binding]; other site 644042003309 LytTr DNA-binding domain; Region: LytTR; pfam04397 644042003310 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 644042003311 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644042003312 putative DNA binding site [nucleotide binding]; other site 644042003313 putative Zn2+ binding site [ion binding]; other site 644042003314 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 644042003315 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042003316 Walker A/P-loop; other site 644042003317 ATP binding site [chemical binding]; other site 644042003318 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 644042003319 Q-loop/lid; other site 644042003320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042003321 ABC transporter signature motif; other site 644042003322 Walker B; other site 644042003323 D-loop; other site 644042003324 H-loop/switch region; other site 644042003325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042003326 Walker A/P-loop; other site 644042003327 ATP binding site [chemical binding]; other site 644042003328 Q-loop/lid; other site 644042003329 ABC transporter signature motif; other site 644042003330 Walker B; other site 644042003331 D-loop; other site 644042003332 H-loop/switch region; other site 644042003333 Predicted membrane protein [Function unknown]; Region: COG2246 644042003334 GtrA-like protein; Region: GtrA; pfam04138 644042003335 Protein of unknown function (DUF1516); Region: DUF1516; pfam07457 644042003336 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 644042003337 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 644042003338 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 644042003339 FAD binding site [chemical binding]; other site 644042003340 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 644042003341 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 644042003342 THF binding site; other site 644042003343 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 644042003344 substrate binding site [chemical binding]; other site 644042003345 THF binding site; other site 644042003346 zinc-binding site [ion binding]; other site 644042003347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 644042003348 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 644042003349 ATP-sulfurylase; Region: ATPS; cd00517 644042003350 active site 644042003351 HXXH motif; other site 644042003352 flexible loop; other site 644042003353 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 644042003354 ligand-binding site [chemical binding]; other site 644042003355 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 644042003356 DHH family; Region: DHH; pfam01368 644042003357 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 644042003358 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 644042003359 TrkA-C domain; Region: TrkA_C; pfam02080 644042003360 TrkA-C domain; Region: TrkA_C; pfam02080 644042003361 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 644042003362 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 644042003363 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 644042003364 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 644042003365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 644042003366 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 644042003367 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 644042003368 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 644042003369 active site 644042003370 HIGH motif; other site 644042003371 KMSK motif region; other site 644042003372 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 644042003373 tRNA binding surface [nucleotide binding]; other site 644042003374 anticodon binding site; other site 644042003375 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 644042003376 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644042003377 Walker A/P-loop; other site 644042003378 ATP binding site [chemical binding]; other site 644042003379 Q-loop/lid; other site 644042003380 ABC transporter signature motif; other site 644042003381 Walker B; other site 644042003382 D-loop; other site 644042003383 H-loop/switch region; other site 644042003384 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 644042003385 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 644042003386 FtsX-like permease family; Region: FtsX; pfam02687 644042003387 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 644042003388 Transcriptional antiterminator [Transcription]; Region: COG3933 644042003389 PRD domain; Region: PRD; pfam00874 644042003390 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 644042003391 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 644042003392 active site 644042003393 methionine cluster; other site 644042003394 phosphorylation site [posttranslational modification] 644042003395 metal binding site [ion binding]; metal-binding site 644042003396 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 644042003397 active site 644042003398 P-loop; other site 644042003399 phosphorylation site [posttranslational modification] 644042003400 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 644042003401 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 644042003402 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 644042003403 beta-galactosidase; Region: BGL; TIGR03356 644042003404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042003405 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042003406 putative substrate translocation pore; other site 644042003407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 644042003408 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 644042003409 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 644042003410 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 644042003411 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042003412 DNA-binding site [nucleotide binding]; DNA binding site 644042003413 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644042003414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042003415 homodimer interface [polypeptide binding]; other site 644042003416 catalytic residue [active] 644042003417 LysE type translocator; Region: LysE; cl00565 644042003418 transaminase; Validated; Region: PRK07324 644042003419 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644042003420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042003421 homodimer interface [polypeptide binding]; other site 644042003422 catalytic residue [active] 644042003423 Arginine repressor [Transcription]; Region: ArgR; COG1438 644042003424 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 644042003425 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 644042003426 Transglycosylase; Region: Transgly; pfam00912 644042003427 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 644042003428 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 644042003429 hypothetical protein; Provisional; Region: PRK13676 644042003430 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 644042003431 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 644042003432 active site 644042003433 metal binding site [ion binding]; metal-binding site 644042003434 DNA binding site [nucleotide binding] 644042003435 Uncharacterized conserved protein [Function unknown]; Region: COG4717 644042003436 Uncharacterized conserved protein [Function unknown]; Region: COG4717 644042003437 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 644042003438 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 644042003439 generic binding surface II; other site 644042003440 generic binding surface I; other site 644042003441 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644042003442 Zn2+ binding site [ion binding]; other site 644042003443 Mg2+ binding site [ion binding]; other site 644042003444 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 644042003445 Active site serine [active] 644042003446 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042003447 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042003448 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 644042003449 dimerization interface [polypeptide binding]; other site 644042003450 Predicted flavoprotein [General function prediction only]; Region: COG0431 644042003451 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 644042003452 Predicted flavoprotein [General function prediction only]; Region: COG0431 644042003453 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 644042003454 FMN-binding domain; Region: FMN_bind; cl01081 644042003455 FAD binding domain; Region: FAD_binding_2; pfam00890 644042003456 L-aspartate oxidase; Provisional; Region: PRK06175 644042003457 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 644042003458 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 644042003459 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 644042003460 Ligand binding site; other site 644042003461 Putative Catalytic site; other site 644042003462 DXD motif; other site 644042003463 conserved hypothetical integral membrane protein; Region: TIGR03766 644042003464 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 644042003465 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 644042003466 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 644042003467 catalytic motif [active] 644042003468 Zn binding site [ion binding]; other site 644042003469 RibD C-terminal domain; Region: RibD_C; cl17279 644042003470 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 644042003471 Lumazine binding domain; Region: Lum_binding; pfam00677 644042003472 Lumazine binding domain; Region: Lum_binding; pfam00677 644042003473 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 644042003474 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 644042003475 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 644042003476 dimerization interface [polypeptide binding]; other site 644042003477 active site 644042003478 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 644042003479 homopentamer interface [polypeptide binding]; other site 644042003480 active site 644042003481 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 644042003482 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 644042003483 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 644042003484 ligand binding site [chemical binding]; other site 644042003485 flexible hinge region; other site 644042003486 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 644042003487 non-specific DNA interactions [nucleotide binding]; other site 644042003488 DNA binding site [nucleotide binding] 644042003489 sequence specific DNA binding site [nucleotide binding]; other site 644042003490 putative cAMP binding site [chemical binding]; other site 644042003491 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042003492 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 644042003493 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644042003494 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 644042003495 WxL domain surface cell wall-binding; Region: WxL; pfam13731 644042003496 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 644042003497 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 644042003498 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 644042003499 WxL domain surface cell wall-binding; Region: WxL; pfam13731 644042003500 WxL domain surface cell wall-binding; Region: WxL; pfam13731 644042003501 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 644042003502 SurA N-terminal domain; Region: SurA_N; pfam09312 644042003503 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 644042003504 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 644042003505 HIT family signature motif; other site 644042003506 catalytic residue [active] 644042003507 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 644042003508 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 644042003509 Walker A/P-loop; other site 644042003510 ATP binding site [chemical binding]; other site 644042003511 Q-loop/lid; other site 644042003512 ABC transporter signature motif; other site 644042003513 Walker B; other site 644042003514 D-loop; other site 644042003515 H-loop/switch region; other site 644042003516 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 644042003517 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 644042003518 active site 644042003519 substrate binding site [chemical binding]; other site 644042003520 ATP binding site [chemical binding]; other site 644042003521 Phosphotransferase enzyme family; Region: APH; pfam01636 644042003522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644042003523 S-adenosylmethionine binding site [chemical binding]; other site 644042003524 Predicted small secreted protein [Function unknown]; Region: COG5584 644042003525 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 644042003526 putative tRNA-binding site [nucleotide binding]; other site 644042003527 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 644042003528 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 644042003529 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 644042003530 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 644042003531 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 644042003532 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644042003533 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644042003534 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 644042003535 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 644042003536 G1 box; other site 644042003537 GTP/Mg2+ binding site [chemical binding]; other site 644042003538 Switch I region; other site 644042003539 G2 box; other site 644042003540 G3 box; other site 644042003541 Switch II region; other site 644042003542 G4 box; other site 644042003543 G5 box; other site 644042003544 Nucleoside recognition; Region: Gate; pfam07670 644042003545 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 644042003546 Nucleoside recognition; Region: Gate; pfam07670 644042003547 FeoA domain; Region: FeoA; pfam04023 644042003548 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 644042003549 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 644042003550 Walker A/P-loop; other site 644042003551 ATP binding site [chemical binding]; other site 644042003552 Q-loop/lid; other site 644042003553 ABC transporter signature motif; other site 644042003554 Walker B; other site 644042003555 D-loop; other site 644042003556 H-loop/switch region; other site 644042003557 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 644042003558 FeS assembly protein SufD; Region: sufD; TIGR01981 644042003559 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 644042003560 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 644042003561 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644042003562 catalytic residue [active] 644042003563 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 644042003564 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 644042003565 trimerization site [polypeptide binding]; other site 644042003566 active site 644042003567 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 644042003568 FeS assembly protein SufB; Region: sufB; TIGR01980 644042003569 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 644042003570 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 644042003571 putative ligand binding residues [chemical binding]; other site 644042003572 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 644042003573 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 644042003574 Walker A/P-loop; other site 644042003575 ATP binding site [chemical binding]; other site 644042003576 Q-loop/lid; other site 644042003577 ABC transporter signature motif; other site 644042003578 Walker B; other site 644042003579 D-loop; other site 644042003580 H-loop/switch region; other site 644042003581 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 644042003582 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644042003583 dimer interface [polypeptide binding]; other site 644042003584 putative PBP binding regions; other site 644042003585 ABC-ATPase subunit interface; other site 644042003586 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 644042003587 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 644042003588 MoaE homodimer interface [polypeptide binding]; other site 644042003589 MoaD interaction [polypeptide binding]; other site 644042003590 active site residues [active] 644042003591 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 644042003592 MoaE interaction surface [polypeptide binding]; other site 644042003593 MoeB interaction surface [polypeptide binding]; other site 644042003594 thiocarboxylated glycine; other site 644042003595 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 644042003596 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644042003597 FeS/SAM binding site; other site 644042003598 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 644042003599 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 644042003600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042003601 putative substrate translocation pore; other site 644042003602 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 644042003603 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042003604 non-specific DNA binding site [nucleotide binding]; other site 644042003605 salt bridge; other site 644042003606 sequence-specific DNA binding site [nucleotide binding]; other site 644042003607 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 644042003608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644042003609 active site 644042003610 phosphorylation site [posttranslational modification] 644042003611 intermolecular recognition site; other site 644042003612 dimerization interface [polypeptide binding]; other site 644042003613 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644042003614 DNA binding residues [nucleotide binding] 644042003615 dimerization interface [polypeptide binding]; other site 644042003616 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 644042003617 Histidine kinase; Region: HisKA_3; pfam07730 644042003618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644042003619 ATP binding site [chemical binding]; other site 644042003620 Mg2+ binding site [ion binding]; other site 644042003621 G-X-G motif; other site 644042003622 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 644042003623 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 644042003624 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 644042003625 GTP binding site; other site 644042003626 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 644042003627 trimer interface [polypeptide binding]; other site 644042003628 dimer interface [polypeptide binding]; other site 644042003629 putative active site [active] 644042003630 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 644042003631 Walker A motif; other site 644042003632 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 644042003633 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 644042003634 dimer interface [polypeptide binding]; other site 644042003635 putative functional site; other site 644042003636 putative MPT binding site; other site 644042003637 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 644042003638 MPT binding site; other site 644042003639 trimer interface [polypeptide binding]; other site 644042003640 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 644042003641 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 644042003642 ATP binding site [chemical binding]; other site 644042003643 substrate interface [chemical binding]; other site 644042003644 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 644042003645 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 644042003646 [4Fe-4S] binding site [ion binding]; other site 644042003647 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 644042003648 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 644042003649 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 644042003650 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 644042003651 molybdopterin cofactor binding site; other site 644042003652 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 644042003653 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 644042003654 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 644042003655 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644042003656 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042003657 sequence-specific DNA binding site [nucleotide binding]; other site 644042003658 salt bridge; other site 644042003659 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 644042003660 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 644042003661 DNA polymerase I; Provisional; Region: PRK05755 644042003662 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 644042003663 active site 644042003664 metal binding site 1 [ion binding]; metal-binding site 644042003665 putative 5' ssDNA interaction site; other site 644042003666 metal binding site 3; metal-binding site 644042003667 metal binding site 2 [ion binding]; metal-binding site 644042003668 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 644042003669 putative DNA binding site [nucleotide binding]; other site 644042003670 putative metal binding site [ion binding]; other site 644042003671 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 644042003672 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 644042003673 active site 644042003674 DNA binding site [nucleotide binding] 644042003675 catalytic site [active] 644042003676 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 644042003677 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 644042003678 DNA binding site [nucleotide binding] 644042003679 catalytic residue [active] 644042003680 H2TH interface [polypeptide binding]; other site 644042003681 putative catalytic residues [active] 644042003682 turnover-facilitating residue; other site 644042003683 intercalation triad [nucleotide binding]; other site 644042003684 8OG recognition residue [nucleotide binding]; other site 644042003685 putative reading head residues; other site 644042003686 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 644042003687 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 644042003688 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 644042003689 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 644042003690 CoA-binding site [chemical binding]; other site 644042003691 ATP-binding [chemical binding]; other site 644042003692 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 644042003693 ATP cone domain; Region: ATP-cone; pfam03477 644042003694 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 644042003695 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 644042003696 primosomal protein DnaI; Reviewed; Region: PRK08939 644042003697 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 644042003698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042003699 Walker A motif; other site 644042003700 ATP binding site [chemical binding]; other site 644042003701 Walker B motif; other site 644042003702 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 644042003703 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 644042003704 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 644042003705 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 644042003706 active site 644042003707 dimer interface [polypeptide binding]; other site 644042003708 motif 1; other site 644042003709 motif 2; other site 644042003710 motif 3; other site 644042003711 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 644042003712 anticodon binding site; other site 644042003713 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 644042003714 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 644042003715 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 644042003716 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 644042003717 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 644042003718 23S rRNA binding site [nucleotide binding]; other site 644042003719 L21 binding site [polypeptide binding]; other site 644042003720 L13 binding site [polypeptide binding]; other site 644042003721 recombination factor protein RarA; Reviewed; Region: PRK13342 644042003722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042003723 Walker A motif; other site 644042003724 ATP binding site [chemical binding]; other site 644042003725 Walker B motif; other site 644042003726 arginine finger; other site 644042003727 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 644042003728 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 644042003729 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 644042003730 putative NAD(P) binding site [chemical binding]; other site 644042003731 dimer interface [polypeptide binding]; other site 644042003732 Predicted transcriptional regulators [Transcription]; Region: COG1733 644042003733 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 644042003734 potential frameshift: common BLAST hit: gi|28378236|ref|NP_785128.1| aspartate racemase 644042003735 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 644042003736 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 644042003737 N-glycosyltransferase; Provisional; Region: PRK11204 644042003738 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 644042003739 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 644042003740 DXD motif; other site 644042003741 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 644042003742 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042003743 active site 644042003744 motif I; other site 644042003745 motif II; other site 644042003746 GTPase YqeH; Provisional; Region: PRK13796 644042003747 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 644042003748 GTP/Mg2+ binding site [chemical binding]; other site 644042003749 G4 box; other site 644042003750 G5 box; other site 644042003751 G1 box; other site 644042003752 Switch I region; other site 644042003753 G2 box; other site 644042003754 G3 box; other site 644042003755 Switch II region; other site 644042003756 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 644042003757 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 644042003758 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 644042003759 active site 644042003760 (T/H)XGH motif; other site 644042003761 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644042003762 Zn2+ binding site [ion binding]; other site 644042003763 Mg2+ binding site [ion binding]; other site 644042003764 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 644042003765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644042003766 S-adenosylmethionine binding site [chemical binding]; other site 644042003767 hypothetical protein; Provisional; Region: PRK13670 644042003768 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 644042003769 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 644042003770 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 644042003771 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 644042003772 Predicted membrane protein [Function unknown]; Region: COG3212 644042003773 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 644042003774 Cation efflux family; Region: Cation_efflux; pfam01545 644042003775 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 644042003776 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 644042003777 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 644042003778 recombination factor protein RarA; Reviewed; Region: PRK13342 644042003779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042003780 Walker A motif; other site 644042003781 ATP binding site [chemical binding]; other site 644042003782 Walker B motif; other site 644042003783 arginine finger; other site 644042003784 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 644042003785 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644042003786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644042003787 active site 644042003788 phosphorylation site [posttranslational modification] 644042003789 intermolecular recognition site; other site 644042003790 dimerization interface [polypeptide binding]; other site 644042003791 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644042003792 DNA binding site [nucleotide binding] 644042003793 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 644042003794 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644042003795 dimerization interface [polypeptide binding]; other site 644042003796 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644042003797 dimer interface [polypeptide binding]; other site 644042003798 phosphorylation site [posttranslational modification] 644042003799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644042003800 ATP binding site [chemical binding]; other site 644042003801 Mg2+ binding site [ion binding]; other site 644042003802 G-X-G motif; other site 644042003803 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 644042003804 UbiA prenyltransferase family; Region: UbiA; pfam01040 644042003805 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 644042003806 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 644042003807 Walker A/P-loop; other site 644042003808 ATP binding site [chemical binding]; other site 644042003809 Q-loop/lid; other site 644042003810 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 644042003811 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 644042003812 ABC transporter signature motif; other site 644042003813 Walker B; other site 644042003814 D-loop; other site 644042003815 H-loop/switch region; other site 644042003816 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 644042003817 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 644042003818 active site 644042003819 metal binding site [ion binding]; metal-binding site 644042003820 DNA binding site [nucleotide binding] 644042003821 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 644042003822 SdpI/YhfL protein family; Region: SdpI; pfam13630 644042003823 OxaA-like protein precursor; Provisional; Region: PRK02463 644042003824 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 644042003825 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 644042003826 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 644042003827 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 644042003828 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 644042003829 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 644042003830 Predicted transcriptional regulators [Transcription]; Region: COG1733 644042003831 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 644042003832 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 644042003833 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 644042003834 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 644042003835 dimer interface [polypeptide binding]; other site 644042003836 motif 1; other site 644042003837 active site 644042003838 motif 2; other site 644042003839 motif 3; other site 644042003840 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 644042003841 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 644042003842 putative tRNA-binding site [nucleotide binding]; other site 644042003843 B3/4 domain; Region: B3_4; pfam03483 644042003844 tRNA synthetase B5 domain; Region: B5; smart00874 644042003845 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 644042003846 dimer interface [polypeptide binding]; other site 644042003847 motif 1; other site 644042003848 motif 3; other site 644042003849 motif 2; other site 644042003850 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 644042003851 YceG-like family; Region: YceG; pfam02618 644042003852 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 644042003853 dimerization interface [polypeptide binding]; other site 644042003854 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 644042003855 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 644042003856 Pyrimidine base specificity; other site 644042003857 Sugar specificity; other site 644042003858 ATP-binding site [chemical binding]; other site 644042003859 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 644042003860 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 644042003861 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 644042003862 LytTr DNA-binding domain; Region: LytTR; pfam04397 644042003863 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 644042003864 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 644042003865 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 644042003866 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 644042003867 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 644042003868 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 644042003869 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 644042003870 Rhomboid family; Region: Rhomboid; pfam01694 644042003871 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 644042003872 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 644042003873 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 644042003874 nucleotide binding site [chemical binding]; other site 644042003875 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 644042003876 catalytic triad [active] 644042003877 active site nucleophile [active] 644042003878 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 644042003879 active site residue [active] 644042003880 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 644042003881 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 644042003882 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 644042003883 active site 644042003884 catalytic site [active] 644042003885 metal binding site [ion binding]; metal-binding site 644042003886 dimer interface [polypeptide binding]; other site 644042003887 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 644042003888 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 644042003889 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 644042003890 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 644042003891 DNA binding residues [nucleotide binding] 644042003892 putative dimer interface [polypeptide binding]; other site 644042003893 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 644042003894 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 644042003895 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 644042003896 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 644042003897 dUTPase; Region: dUTPase_2; pfam08761 644042003898 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 644042003899 active site 644042003900 homodimer interface [polypeptide binding]; other site 644042003901 metal binding site [ion binding]; metal-binding site 644042003902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042003903 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 644042003904 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 644042003905 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 644042003906 Protein of unknown function (DUF464); Region: DUF464; pfam04327 644042003907 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 644042003908 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 644042003909 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 644042003910 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 644042003911 active site 644042003912 elongation factor P; Validated; Region: PRK00529 644042003913 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 644042003914 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 644042003915 RNA binding site [nucleotide binding]; other site 644042003916 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 644042003917 RNA binding site [nucleotide binding]; other site 644042003918 Asp23 family; Region: Asp23; pfam03780 644042003919 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 644042003920 putative RNA binding site [nucleotide binding]; other site 644042003921 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 644042003922 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 644042003923 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 644042003924 homodimer interface [polypeptide binding]; other site 644042003925 NADP binding site [chemical binding]; other site 644042003926 substrate binding site [chemical binding]; other site 644042003927 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 644042003928 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 644042003929 generic binding surface II; other site 644042003930 generic binding surface I; other site 644042003931 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 644042003932 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 644042003933 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 644042003934 substrate binding pocket [chemical binding]; other site 644042003935 chain length determination region; other site 644042003936 substrate-Mg2+ binding site; other site 644042003937 catalytic residues [active] 644042003938 aspartate-rich region 1; other site 644042003939 active site lid residues [active] 644042003940 aspartate-rich region 2; other site 644042003941 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 644042003942 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644042003943 RNA binding surface [nucleotide binding]; other site 644042003944 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 644042003945 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 644042003946 arginine repressor; Provisional; Region: PRK04280 644042003947 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 644042003948 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 644042003949 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 644042003950 Walker A/P-loop; other site 644042003951 ATP binding site [chemical binding]; other site 644042003952 Q-loop/lid; other site 644042003953 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 644042003954 ABC transporter signature motif; other site 644042003955 Walker B; other site 644042003956 D-loop; other site 644042003957 H-loop/switch region; other site 644042003958 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 644042003959 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 644042003960 Walker A/P-loop; other site 644042003961 ATP binding site [chemical binding]; other site 644042003962 Q-loop/lid; other site 644042003963 ABC transporter signature motif; other site 644042003964 Walker B; other site 644042003965 D-loop; other site 644042003966 H-loop/switch region; other site 644042003967 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 644042003968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042003969 dimer interface [polypeptide binding]; other site 644042003970 conserved gate region; other site 644042003971 putative PBP binding loops; other site 644042003972 ABC-ATPase subunit interface; other site 644042003973 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 644042003974 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 644042003975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042003976 dimer interface [polypeptide binding]; other site 644042003977 conserved gate region; other site 644042003978 putative PBP binding loops; other site 644042003979 ABC-ATPase subunit interface; other site 644042003980 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 644042003981 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 644042003982 catalytic site [active] 644042003983 G-X2-G-X-G-K; other site 644042003984 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 644042003985 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 644042003986 Flavoprotein; Region: Flavoprotein; pfam02441 644042003987 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 644042003988 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 644042003989 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644042003990 ATP binding site [chemical binding]; other site 644042003991 putative Mg++ binding site [ion binding]; other site 644042003992 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644042003993 nucleotide binding region [chemical binding]; other site 644042003994 ATP-binding site [chemical binding]; other site 644042003995 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 644042003996 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 644042003997 putative active site [active] 644042003998 substrate binding site [chemical binding]; other site 644042003999 putative cosubstrate binding site; other site 644042004000 catalytic site [active] 644042004001 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 644042004002 substrate binding site [chemical binding]; other site 644042004003 16S rRNA methyltransferase B; Provisional; Region: PRK14902 644042004004 NusB family; Region: NusB; pfam01029 644042004005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644042004006 S-adenosylmethionine binding site [chemical binding]; other site 644042004007 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 644042004008 active site 644042004009 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 644042004010 Catalytic domain of Protein Kinases; Region: PKc; cd00180 644042004011 active site 644042004012 ATP binding site [chemical binding]; other site 644042004013 substrate binding site [chemical binding]; other site 644042004014 activation loop (A-loop); other site 644042004015 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 644042004016 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 644042004017 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 644042004018 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 644042004019 GTPase RsgA; Reviewed; Region: PRK00098 644042004020 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 644042004021 RNA binding site [nucleotide binding]; other site 644042004022 homodimer interface [polypeptide binding]; other site 644042004023 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 644042004024 GTPase/Zn-binding domain interface [polypeptide binding]; other site 644042004025 GTP/Mg2+ binding site [chemical binding]; other site 644042004026 G4 box; other site 644042004027 G5 box; other site 644042004028 G1 box; other site 644042004029 Switch I region; other site 644042004030 G2 box; other site 644042004031 G3 box; other site 644042004032 Switch II region; other site 644042004033 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 644042004034 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 644042004035 substrate binding site [chemical binding]; other site 644042004036 hexamer interface [polypeptide binding]; other site 644042004037 metal binding site [ion binding]; metal-binding site 644042004038 Thiamine pyrophosphokinase; Region: TPK; cd07995 644042004039 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 644042004040 active site 644042004041 dimerization interface [polypeptide binding]; other site 644042004042 thiamine binding site [chemical binding]; other site 644042004043 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 644042004044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 644042004045 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 644042004046 DAK2 domain; Region: Dak2; pfam02734 644042004047 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 644042004048 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 644042004049 generic binding surface II; other site 644042004050 ssDNA binding site; other site 644042004051 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644042004052 ATP binding site [chemical binding]; other site 644042004053 putative Mg++ binding site [ion binding]; other site 644042004054 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644042004055 nucleotide binding region [chemical binding]; other site 644042004056 ATP-binding site [chemical binding]; other site 644042004057 putative phosphate acyltransferase; Provisional; Region: PRK05331 644042004058 acyl carrier protein; Provisional; Region: acpP; PRK00982 644042004059 ribonuclease III; Reviewed; Region: rnc; PRK00102 644042004060 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 644042004061 dimerization interface [polypeptide binding]; other site 644042004062 active site 644042004063 metal binding site [ion binding]; metal-binding site 644042004064 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 644042004065 dsRNA binding site [nucleotide binding]; other site 644042004066 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 644042004067 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 644042004068 Walker A/P-loop; other site 644042004069 ATP binding site [chemical binding]; other site 644042004070 Q-loop/lid; other site 644042004071 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 644042004072 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 644042004073 ABC transporter signature motif; other site 644042004074 Walker B; other site 644042004075 D-loop; other site 644042004076 H-loop/switch region; other site 644042004077 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 644042004078 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 644042004079 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 644042004080 P loop; other site 644042004081 GTP binding site [chemical binding]; other site 644042004082 putative DNA-binding protein; Validated; Region: PRK00118 644042004083 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 644042004084 signal recognition particle protein; Provisional; Region: PRK10867 644042004085 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 644042004086 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 644042004087 P loop; other site 644042004088 GTP binding site [chemical binding]; other site 644042004089 Signal peptide binding domain; Region: SRP_SPB; pfam02978 644042004090 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 644042004091 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 644042004092 KH domain; Region: KH_4; pfam13083 644042004093 G-X-X-G motif; other site 644042004094 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 644042004095 RimM N-terminal domain; Region: RimM; pfam01782 644042004096 PRC-barrel domain; Region: PRC; pfam05239 644042004097 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 644042004098 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 644042004099 Enterocin A Immunity; Region: EntA_Immun; pfam08951 644042004100 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 644042004101 MucBP domain; Region: MucBP; pfam06458 644042004102 MucBP domain; Region: MucBP; pfam06458 644042004103 MucBP domain; Region: MucBP; pfam06458 644042004104 MucBP domain; Region: MucBP; pfam06458 644042004105 MucBP domain; Region: MucBP; pfam06458 644042004106 MucBP domain; Region: MucBP; pfam06458 644042004107 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 644042004108 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 644042004109 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 644042004110 Walker A/P-loop; other site 644042004111 ATP binding site [chemical binding]; other site 644042004112 Q-loop/lid; other site 644042004113 ABC transporter signature motif; other site 644042004114 Walker B; other site 644042004115 D-loop; other site 644042004116 H-loop/switch region; other site 644042004117 potential frameshift: common BLAST hit: gi|28378344|ref|NP_785236.1| anthranilate synthase, component I 644042004118 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 644042004119 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 644042004120 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 644042004121 chorismate binding enzyme; Region: Chorismate_bind; cl10555 644042004122 Glutamine amidotransferase class-I; Region: GATase; pfam00117 644042004123 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 644042004124 glutamine binding [chemical binding]; other site 644042004125 catalytic triad [active] 644042004126 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 644042004127 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 644042004128 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 644042004129 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 644042004130 active site 644042004131 ribulose/triose binding site [chemical binding]; other site 644042004132 phosphate binding site [ion binding]; other site 644042004133 substrate (anthranilate) binding pocket [chemical binding]; other site 644042004134 product (indole) binding pocket [chemical binding]; other site 644042004135 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 644042004136 active site 644042004137 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 644042004138 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 644042004139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042004140 catalytic residue [active] 644042004141 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 644042004142 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 644042004143 substrate binding site [chemical binding]; other site 644042004144 active site 644042004145 catalytic residues [active] 644042004146 heterodimer interface [polypeptide binding]; other site 644042004147 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 644042004148 Isochorismatase family; Region: Isochorismatase; pfam00857 644042004149 catalytic triad [active] 644042004150 conserved cis-peptide bond; other site 644042004151 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 644042004152 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 644042004153 NADP binding site [chemical binding]; other site 644042004154 dimer interface [polypeptide binding]; other site 644042004155 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 644042004156 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 644042004157 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 644042004158 metal binding site [ion binding]; metal-binding site 644042004159 dimer interface [polypeptide binding]; other site 644042004160 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 644042004161 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 644042004162 catalytic Zn binding site [ion binding]; other site 644042004163 NAD(P) binding site [chemical binding]; other site 644042004164 structural Zn binding site [ion binding]; other site 644042004165 short chain dehydrogenase; Validated; Region: PRK06182 644042004166 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 644042004167 NADP binding site [chemical binding]; other site 644042004168 active site 644042004169 steroid binding site; other site 644042004170 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 644042004171 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 644042004172 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 644042004173 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 644042004174 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 644042004175 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 644042004176 dimer interface [polypeptide binding]; other site 644042004177 active site 644042004178 CoA binding pocket [chemical binding]; other site 644042004179 acyl carrier protein; Provisional; Region: acpP; PRK00982 644042004180 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 644042004181 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 644042004182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644042004183 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 644042004184 NAD(P) binding site [chemical binding]; other site 644042004185 active site 644042004186 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 644042004187 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 644042004188 dimer interface [polypeptide binding]; other site 644042004189 active site 644042004190 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 644042004191 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 644042004192 carboxyltransferase (CT) interaction site; other site 644042004193 biotinylation site [posttranslational modification]; other site 644042004194 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 644042004195 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 644042004196 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 644042004197 ATP-grasp domain; Region: ATP-grasp_4; cl17255 644042004198 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 644042004199 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 644042004200 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 644042004201 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 644042004202 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 644042004203 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 644042004204 NAD binding site [chemical binding]; other site 644042004205 homotetramer interface [polypeptide binding]; other site 644042004206 homodimer interface [polypeptide binding]; other site 644042004207 substrate binding site [chemical binding]; other site 644042004208 active site 644042004209 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 644042004210 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 644042004211 Protein of unknown function (DUF554); Region: DUF554; pfam04474 644042004212 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042004213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042004214 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 644042004215 dimerization interface [polypeptide binding]; other site 644042004216 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 644042004217 GTPase RsgA; Reviewed; Region: PRK01889 644042004218 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 644042004219 RNA binding site [nucleotide binding]; other site 644042004220 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 644042004221 GTPase/Zn-binding domain interface [polypeptide binding]; other site 644042004222 GTP/Mg2+ binding site [chemical binding]; other site 644042004223 G4 box; other site 644042004224 G5 box; other site 644042004225 G1 box; other site 644042004226 Switch I region; other site 644042004227 G2 box; other site 644042004228 G3 box; other site 644042004229 Switch II region; other site 644042004230 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042004231 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644042004232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042004233 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042004234 putative substrate translocation pore; other site 644042004235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042004236 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 644042004237 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 644042004238 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 644042004239 Enterocin A Immunity; Region: EntA_Immun; pfam08951 644042004240 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 644042004241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644042004242 S-adenosylmethionine binding site [chemical binding]; other site 644042004243 Chitin binding domain; Region: Chitin_bind_3; pfam03067 644042004244 Uncharacterized conserved protein [Function unknown]; Region: COG1359 644042004245 TspO/MBR family; Region: TspO_MBR; pfam03073 644042004246 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644042004247 Ligand Binding Site [chemical binding]; other site 644042004248 Protein of unknown function (DUF805); Region: DUF805; pfam05656 644042004249 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 644042004250 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 644042004251 Predicted membrane protein [Function unknown]; Region: COG2261 644042004252 CsbD-like; Region: CsbD; cl17424 644042004253 Peptidase family C69; Region: Peptidase_C69; pfam03577 644042004254 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 644042004255 active site 1 [active] 644042004256 dimer interface [polypeptide binding]; other site 644042004257 hexamer interface [polypeptide binding]; other site 644042004258 active site 2 [active] 644042004259 diaminopimelate decarboxylase; Region: lysA; TIGR01048 644042004260 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 644042004261 active site 644042004262 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 644042004263 substrate binding site [chemical binding]; other site 644042004264 catalytic residues [active] 644042004265 dimer interface [polypeptide binding]; other site 644042004266 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 644042004267 UbiA prenyltransferase family; Region: UbiA; pfam01040 644042004268 Ion channel; Region: Ion_trans_2; pfam07885 644042004269 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 644042004270 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 644042004271 inhibitor-cofactor binding pocket; inhibition site 644042004272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042004273 catalytic residue [active] 644042004274 amino acid transporter; Region: 2A0306; TIGR00909 644042004275 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 644042004276 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 644042004277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042004278 active site 644042004279 motif I; other site 644042004280 motif II; other site 644042004281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 644042004282 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 644042004283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644042004284 S-adenosylmethionine binding site [chemical binding]; other site 644042004285 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 644042004286 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 644042004287 Double zinc ribbon; Region: DZR; pfam12773 644042004288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042004289 putative substrate translocation pore; other site 644042004290 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042004291 maltose phosphorylase; Provisional; Region: PRK13807 644042004292 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 644042004293 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 644042004294 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 644042004295 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 644042004296 active site 644042004297 catalytic residues [active] 644042004298 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 644042004299 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 644042004300 homotetramer interface [polypeptide binding]; other site 644042004301 FMN binding site [chemical binding]; other site 644042004302 homodimer contacts [polypeptide binding]; other site 644042004303 putative active site [active] 644042004304 putative substrate binding site [chemical binding]; other site 644042004305 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 644042004306 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 644042004307 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 644042004308 diphosphomevalonate decarboxylase; Region: PLN02407 644042004309 mevalonate kinase; Region: mevalon_kin; TIGR00549 644042004310 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 644042004311 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 644042004312 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 644042004313 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 644042004314 active site 644042004315 catalytic site [active] 644042004316 substrate binding site [chemical binding]; other site 644042004317 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644042004318 ATP binding site [chemical binding]; other site 644042004319 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 644042004320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 644042004321 aspartate aminotransferase; Provisional; Region: PRK05764 644042004322 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644042004323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042004324 homodimer interface [polypeptide binding]; other site 644042004325 catalytic residue [active] 644042004326 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 644042004327 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 644042004328 Dimer interface [polypeptide binding]; other site 644042004329 anticodon binding site; other site 644042004330 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 644042004331 homodimer interface [polypeptide binding]; other site 644042004332 motif 1; other site 644042004333 motif 2; other site 644042004334 active site 644042004335 motif 3; other site 644042004336 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 644042004337 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 644042004338 ABC transporter; Region: ABC_tran; pfam00005 644042004339 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042004340 Q-loop/lid; other site 644042004341 ABC transporter signature motif; other site 644042004342 Walker B; other site 644042004343 D-loop; other site 644042004344 H-loop/switch region; other site 644042004345 NIL domain; Region: NIL; pfam09383 644042004346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042004347 dimer interface [polypeptide binding]; other site 644042004348 conserved gate region; other site 644042004349 ABC-ATPase subunit interface; other site 644042004350 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 644042004351 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 644042004352 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644042004353 Ligand Binding Site [chemical binding]; other site 644042004354 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 644042004355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042004356 dimer interface [polypeptide binding]; other site 644042004357 conserved gate region; other site 644042004358 putative PBP binding loops; other site 644042004359 ABC-ATPase subunit interface; other site 644042004360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042004361 dimer interface [polypeptide binding]; other site 644042004362 conserved gate region; other site 644042004363 putative PBP binding loops; other site 644042004364 ABC-ATPase subunit interface; other site 644042004365 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 644042004366 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 644042004367 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 644042004368 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 644042004369 Walker A/P-loop; other site 644042004370 ATP binding site [chemical binding]; other site 644042004371 Q-loop/lid; other site 644042004372 ABC transporter signature motif; other site 644042004373 Walker B; other site 644042004374 D-loop; other site 644042004375 H-loop/switch region; other site 644042004376 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 644042004377 Transglycosylase; Region: Transgly; pfam00912 644042004378 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 644042004379 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 644042004380 hypothetical protein; Provisional; Region: PRK13660 644042004381 cell division protein GpsB; Provisional; Region: PRK14127 644042004382 DivIVA domain; Region: DivI1A_domain; TIGR03544 644042004383 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 644042004384 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 644042004385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 644042004386 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644042004387 dimerization interface [polypeptide binding]; other site 644042004388 putative DNA binding site [nucleotide binding]; other site 644042004389 putative Zn2+ binding site [ion binding]; other site 644042004390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042004391 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042004392 putative substrate translocation pore; other site 644042004393 esterase; Provisional; Region: PRK10566 644042004394 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 644042004395 SnoaL-like domain; Region: SnoaL_2; pfam12680 644042004396 putative glycosyl transferase; Provisional; Region: PRK10073 644042004397 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 644042004398 active site 644042004399 potential frameshift: common BLAST hit: gi|28378441|ref|NP_785333.1| bacteriocin immunity protein () 644042004400 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 644042004401 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 644042004402 putative dimer interface [polypeptide binding]; other site 644042004403 catalytic triad [active] 644042004404 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 644042004405 active site 644042004406 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 644042004407 putative dimer interface [polypeptide binding]; other site 644042004408 catalytic triad [active] 644042004409 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644042004410 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 644042004411 Walker A/P-loop; other site 644042004412 ATP binding site [chemical binding]; other site 644042004413 Q-loop/lid; other site 644042004414 ABC transporter signature motif; other site 644042004415 Walker B; other site 644042004416 D-loop; other site 644042004417 H-loop/switch region; other site 644042004418 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 644042004419 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 644042004420 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644042004421 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 644042004422 RNA/DNA hybrid binding site [nucleotide binding]; other site 644042004423 active site 644042004424 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 644042004425 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 644042004426 Potassium binding sites [ion binding]; other site 644042004427 Cesium cation binding sites [ion binding]; other site 644042004428 lipoprotein signal peptidase; Provisional; Region: PRK14797 644042004429 lipoprotein signal peptidase; Provisional; Region: PRK14787 644042004430 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 644042004431 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644042004432 RNA binding surface [nucleotide binding]; other site 644042004433 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 644042004434 active site 644042004435 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 644042004436 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644042004437 active site 644042004438 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 644042004439 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 644042004440 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 644042004441 catalytic site [active] 644042004442 subunit interface [polypeptide binding]; other site 644042004443 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 644042004444 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 644042004445 ATP-grasp domain; Region: ATP-grasp_4; cl17255 644042004446 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 644042004447 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 644042004448 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644042004449 catalytic core [active] 644042004450 Domain of unknown function (DU1801); Region: DUF1801; cl17490 644042004451 Domain of unknown function (DU1801); Region: DUF1801; cl17490 644042004452 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 644042004453 Chloramphenicol acetyltransferase; Region: CAT; smart01059 644042004454 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 644042004455 active site 644042004456 catalytic site [active] 644042004457 metal binding site [ion binding]; metal-binding site 644042004458 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 644042004459 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 644042004460 nudix motif; other site 644042004461 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 644042004462 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042004463 Walker A/P-loop; other site 644042004464 ATP binding site [chemical binding]; other site 644042004465 Q-loop/lid; other site 644042004466 ABC transporter signature motif; other site 644042004467 Walker B; other site 644042004468 D-loop; other site 644042004469 H-loop/switch region; other site 644042004470 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 644042004471 Domain of unknown function (DUF814); Region: DUF814; pfam05670 644042004472 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 644042004473 MarR family; Region: MarR_2; pfam12802 644042004474 EDD domain protein, DegV family; Region: DegV; TIGR00762 644042004475 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 644042004476 Protein of unknown function (DUF975); Region: DUF975; cl10504 644042004477 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 644042004478 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 644042004479 nucleotide binding site/active site [active] 644042004480 HIT family signature motif; other site 644042004481 catalytic residue [active] 644042004482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042004483 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042004484 putative substrate translocation pore; other site 644042004485 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 644042004486 Predicted membrane protein [Function unknown]; Region: COG4420 644042004487 Predicted membrane protein [Function unknown]; Region: COG2035 644042004488 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 644042004489 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 644042004490 L-lactate permease; Region: Lactate_perm; cl00701 644042004491 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 644042004492 substrate binding site; other site 644042004493 dimer interface; other site 644042004494 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 644042004495 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 644042004496 putative NAD(P) binding site [chemical binding]; other site 644042004497 putative catalytic Zn binding site [ion binding]; other site 644042004498 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 644042004499 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 644042004500 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 644042004501 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 644042004502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644042004503 Coenzyme A binding pocket [chemical binding]; other site 644042004504 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 644042004505 MarR family; Region: MarR; pfam01047 644042004506 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 644042004507 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644042004508 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644042004509 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 644042004510 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 644042004511 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 644042004512 active site 644042004513 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 644042004514 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 644042004515 methionine sulfoxide reductase A; Provisional; Region: PRK14054 644042004516 methionine sulfoxide reductase B; Provisional; Region: PRK00222 644042004517 SelR domain; Region: SelR; pfam01641 644042004518 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 644042004519 DHH family; Region: DHH; pfam01368 644042004520 DHHA2 domain; Region: DHHA2; pfam02833 644042004521 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042004522 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042004523 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 644042004524 dimerization interface [polypeptide binding]; other site 644042004525 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 644042004526 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 644042004527 CAP-like domain; other site 644042004528 active site 644042004529 primary dimer interface [polypeptide binding]; other site 644042004530 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644042004531 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 644042004532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644042004533 ATP binding site [chemical binding]; other site 644042004534 Mg2+ binding site [ion binding]; other site 644042004535 G-X-G motif; other site 644042004536 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 644042004537 anchoring element; other site 644042004538 dimer interface [polypeptide binding]; other site 644042004539 ATP binding site [chemical binding]; other site 644042004540 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 644042004541 active site 644042004542 putative metal-binding site [ion binding]; other site 644042004543 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 644042004544 membrane protein; Provisional; Region: PRK14392 644042004545 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 644042004546 active site 644042004547 catalytic residues [active] 644042004548 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 644042004549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042004550 Walker A motif; other site 644042004551 ATP binding site [chemical binding]; other site 644042004552 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 644042004553 Walker B motif; other site 644042004554 arginine finger; other site 644042004555 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 644042004556 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 644042004557 active site 644042004558 HslU subunit interaction site [polypeptide binding]; other site 644042004559 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 644042004560 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644042004561 active site 644042004562 DNA binding site [nucleotide binding] 644042004563 Int/Topo IB signature motif; other site 644042004564 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 644042004565 Glucose inhibited division protein A; Region: GIDA; pfam01134 644042004566 DNA topoisomerase I; Validated; Region: PRK05582 644042004567 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 644042004568 active site 644042004569 interdomain interaction site; other site 644042004570 putative metal-binding site [ion binding]; other site 644042004571 nucleotide binding site [chemical binding]; other site 644042004572 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 644042004573 domain I; other site 644042004574 DNA binding groove [nucleotide binding] 644042004575 phosphate binding site [ion binding]; other site 644042004576 domain II; other site 644042004577 domain III; other site 644042004578 nucleotide binding site [chemical binding]; other site 644042004579 catalytic site [active] 644042004580 domain IV; other site 644042004581 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 644042004582 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 644042004583 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 644042004584 DNA protecting protein DprA; Region: dprA; TIGR00732 644042004585 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 644042004586 RNA/DNA hybrid binding site [nucleotide binding]; other site 644042004587 active site 644042004588 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 644042004589 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 644042004590 GTP/Mg2+ binding site [chemical binding]; other site 644042004591 G4 box; other site 644042004592 G5 box; other site 644042004593 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 644042004594 G1 box; other site 644042004595 G1 box; other site 644042004596 GTP/Mg2+ binding site [chemical binding]; other site 644042004597 Switch I region; other site 644042004598 G2 box; other site 644042004599 G2 box; other site 644042004600 G3 box; other site 644042004601 G3 box; other site 644042004602 Switch II region; other site 644042004603 Switch II region; other site 644042004604 G4 box; other site 644042004605 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 644042004606 substrate binding site [chemical binding]; other site 644042004607 THF binding site; other site 644042004608 zinc-binding site [ion binding]; other site 644042004609 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042004610 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042004611 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 644042004612 dimerization interface [polypeptide binding]; other site 644042004613 Mrr N-terminal domain; Region: Mrr_N; pfam14338 644042004614 Restriction endonuclease; Region: Mrr_cat; pfam04471 644042004615 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 644042004616 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 644042004617 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 644042004618 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 644042004619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042004620 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042004621 putative substrate translocation pore; other site 644042004622 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 644042004623 C-terminal peptidase (prc); Region: prc; TIGR00225 644042004624 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 644042004625 protein binding site [polypeptide binding]; other site 644042004626 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 644042004627 Catalytic dyad [active] 644042004628 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 644042004629 hypothetical protein; Provisional; Region: PRK13672 644042004630 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 644042004631 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 644042004632 active site 644042004633 catalytic triad [active] 644042004634 oxyanion hole [active] 644042004635 EDD domain protein, DegV family; Region: DegV; TIGR00762 644042004636 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 644042004637 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 644042004638 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 644042004639 folate binding site [chemical binding]; other site 644042004640 NADP+ binding site [chemical binding]; other site 644042004641 thymidylate synthase; Region: thym_sym; TIGR03284 644042004642 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 644042004643 dimerization interface [polypeptide binding]; other site 644042004644 active site 644042004645 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 644042004646 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042004647 Walker A/P-loop; other site 644042004648 ATP binding site [chemical binding]; other site 644042004649 Q-loop/lid; other site 644042004650 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644042004651 ABC transporter signature motif; other site 644042004652 Walker B; other site 644042004653 D-loop; other site 644042004654 ABC transporter; Region: ABC_tran_2; pfam12848 644042004655 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644042004656 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 644042004657 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 644042004658 active site 644042004659 NTP binding site [chemical binding]; other site 644042004660 metal binding triad [ion binding]; metal-binding site 644042004661 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 644042004662 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 644042004663 dihydrodipicolinate reductase; Provisional; Region: PRK00048 644042004664 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 644042004665 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 644042004666 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 644042004667 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 644042004668 active site 644042004669 motif I; other site 644042004670 motif II; other site 644042004671 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042004672 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 644042004673 binding surface 644042004674 TPR motif; other site 644042004675 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 644042004676 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 644042004677 binding surface 644042004678 TPR motif; other site 644042004679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 644042004680 binding surface 644042004681 TPR motif; other site 644042004682 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 644042004683 IHF dimer interface [polypeptide binding]; other site 644042004684 IHF - DNA interface [nucleotide binding]; other site 644042004685 GTP-binding protein Der; Reviewed; Region: PRK00093 644042004686 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 644042004687 G1 box; other site 644042004688 GTP/Mg2+ binding site [chemical binding]; other site 644042004689 Switch I region; other site 644042004690 G2 box; other site 644042004691 Switch II region; other site 644042004692 G3 box; other site 644042004693 G4 box; other site 644042004694 G5 box; other site 644042004695 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 644042004696 G1 box; other site 644042004697 GTP/Mg2+ binding site [chemical binding]; other site 644042004698 Switch I region; other site 644042004699 G2 box; other site 644042004700 G3 box; other site 644042004701 Switch II region; other site 644042004702 G4 box; other site 644042004703 G5 box; other site 644042004704 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 644042004705 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 644042004706 RNA binding site [nucleotide binding]; other site 644042004707 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 644042004708 RNA binding site [nucleotide binding]; other site 644042004709 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 644042004710 RNA binding site [nucleotide binding]; other site 644042004711 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 644042004712 RNA binding site [nucleotide binding]; other site 644042004713 cytidylate kinase; Provisional; Region: cmk; PRK00023 644042004714 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 644042004715 CMP-binding site; other site 644042004716 The sites determining sugar specificity; other site 644042004717 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644042004718 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 644042004719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644042004720 ATP binding site [chemical binding]; other site 644042004721 putative Mg++ binding site [ion binding]; other site 644042004722 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644042004723 nucleotide binding region [chemical binding]; other site 644042004724 ATP-binding site [chemical binding]; other site 644042004725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 644042004726 Predicted membrane protein [Function unknown]; Region: COG3601 644042004727 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 644042004728 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 644042004729 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644042004730 RNA binding surface [nucleotide binding]; other site 644042004731 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 644042004732 active site 644042004733 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 644042004734 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 644042004735 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 644042004736 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 644042004737 active site 644042004738 Int/Topo IB signature motif; other site 644042004739 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 644042004740 S1 domain; Region: S1_2; pfam13509 644042004741 Protein of unknown function (DUF441); Region: DUF441; pfam04284 644042004742 pyruvate kinase; Provisional; Region: PRK06354 644042004743 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 644042004744 domain interfaces; other site 644042004745 active site 644042004746 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 644042004747 6-phosphofructokinase; Provisional; Region: PRK03202 644042004748 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 644042004749 active site 644042004750 ADP/pyrophosphate binding site [chemical binding]; other site 644042004751 dimerization interface [polypeptide binding]; other site 644042004752 allosteric effector site; other site 644042004753 fructose-1,6-bisphosphate binding site; other site 644042004754 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 644042004755 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 644042004756 active site 644042004757 PHP Thumb interface [polypeptide binding]; other site 644042004758 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 644042004759 generic binding surface I; other site 644042004760 generic binding surface II; other site 644042004761 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 644042004762 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 644042004763 Clp amino terminal domain; Region: Clp_N; pfam02861 644042004764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042004765 Walker A motif; other site 644042004766 ATP binding site [chemical binding]; other site 644042004767 Walker B motif; other site 644042004768 arginine finger; other site 644042004769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042004770 Walker A motif; other site 644042004771 ATP binding site [chemical binding]; other site 644042004772 Walker B motif; other site 644042004773 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 644042004774 peptidase T; Region: peptidase-T; TIGR01882 644042004775 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 644042004776 metal binding site [ion binding]; metal-binding site 644042004777 dimer interface [polypeptide binding]; other site 644042004778 Uncharacterized conserved protein [Function unknown]; Region: COG0327 644042004779 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 644042004780 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 644042004781 Uncharacterized conserved protein [Function unknown]; Region: COG0327 644042004782 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 644042004783 Family of unknown function (DUF633); Region: DUF633; pfam04816 644042004784 O-Antigen ligase; Region: Wzy_C; pfam04932 644042004785 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 644042004786 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 644042004787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042004788 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 644042004789 Walker A/P-loop; other site 644042004790 ATP binding site [chemical binding]; other site 644042004791 Q-loop/lid; other site 644042004792 ABC transporter signature motif; other site 644042004793 Walker B; other site 644042004794 D-loop; other site 644042004795 H-loop/switch region; other site 644042004796 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 644042004797 MarR family; Region: MarR_2; pfam12802 644042004798 phosphoenolpyruvate synthase; Validated; Region: PRK06464 644042004799 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 644042004800 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 644042004801 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 644042004802 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 644042004803 active site residue [active] 644042004804 MarR family; Region: MarR_2; cl17246 644042004805 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 644042004806 Acyltransferase family; Region: Acyl_transf_3; pfam01757 644042004807 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 644042004808 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 644042004809 putative NAD(P) binding site [chemical binding]; other site 644042004810 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 644042004811 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 644042004812 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644042004813 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 644042004814 Soluble P-type ATPase [General function prediction only]; Region: COG4087 644042004815 enolase; Provisional; Region: eno; PRK00077 644042004816 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 644042004817 dimer interface [polypeptide binding]; other site 644042004818 metal binding site [ion binding]; metal-binding site 644042004819 substrate binding pocket [chemical binding]; other site 644042004820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042004821 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042004822 putative substrate translocation pore; other site 644042004823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042004824 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 644042004825 MarR family; Region: MarR_2; pfam12802 644042004826 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 644042004827 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 644042004828 metal binding site [ion binding]; metal-binding site 644042004829 dimer interface [polypeptide binding]; other site 644042004830 potential frameshift: common BLAST hit: gi|28378572|ref|NP_785464.1| NADH oxidase () 644042004831 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 644042004832 active site residue [active] 644042004833 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 644042004834 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644042004835 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 644042004836 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 644042004837 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 644042004838 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 644042004839 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 644042004840 nudix motif; other site 644042004841 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 644042004842 ArsC family; Region: ArsC; pfam03960 644042004843 putative catalytic residues [active] 644042004844 thiol/disulfide switch; other site 644042004845 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 644042004846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644042004847 NADH(P)-binding; Region: NAD_binding_10; pfam13460 644042004848 NAD(P) binding site [chemical binding]; other site 644042004849 active site 644042004850 Uncharacterized conserved protein [Function unknown]; Region: COG4715 644042004851 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 644042004852 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042004853 motif II; other site 644042004854 maltose O-acetyltransferase; Provisional; Region: PRK10092 644042004855 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 644042004856 active site 644042004857 substrate binding site [chemical binding]; other site 644042004858 trimer interface [polypeptide binding]; other site 644042004859 CoA binding site [chemical binding]; other site 644042004860 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 644042004861 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 644042004862 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 644042004863 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 644042004864 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 644042004865 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 644042004866 putative active site [active] 644042004867 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 644042004868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644042004869 NADH(P)-binding; Region: NAD_binding_10; pfam13460 644042004870 NAD(P) binding site [chemical binding]; other site 644042004871 active site 644042004872 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012 644042004873 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042004874 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644042004875 putative Zn2+ binding site [ion binding]; other site 644042004876 putative DNA binding site [nucleotide binding]; other site 644042004877 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 644042004878 dimerization interface [polypeptide binding]; other site 644042004879 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 644042004880 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 644042004881 putative NAD(P) binding site [chemical binding]; other site 644042004882 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 644042004883 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644042004884 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 644042004885 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 644042004886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644042004887 active site 644042004888 phosphorylation site [posttranslational modification] 644042004889 intermolecular recognition site; other site 644042004890 dimerization interface [polypeptide binding]; other site 644042004891 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644042004892 DNA binding residues [nucleotide binding] 644042004893 dimerization interface [polypeptide binding]; other site 644042004894 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 644042004895 Histidine kinase; Region: HisKA_3; pfam07730 644042004896 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 644042004897 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 644042004898 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 644042004899 Walker A/P-loop; other site 644042004900 ATP binding site [chemical binding]; other site 644042004901 Q-loop/lid; other site 644042004902 ABC transporter signature motif; other site 644042004903 Walker B; other site 644042004904 D-loop; other site 644042004905 H-loop/switch region; other site 644042004906 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 644042004907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644042004908 Coenzyme A binding pocket [chemical binding]; other site 644042004909 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 644042004910 MarR family; Region: MarR; pfam01047 644042004911 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 644042004912 Predicted membrane protein [Function unknown]; Region: COG2364 644042004913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042004914 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 644042004915 Walker A/P-loop; other site 644042004916 ATP binding site [chemical binding]; other site 644042004917 Q-loop/lid; other site 644042004918 ABC transporter signature motif; other site 644042004919 Walker B; other site 644042004920 D-loop; other site 644042004921 H-loop/switch region; other site 644042004922 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 644042004923 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 644042004924 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 644042004925 Walker A/P-loop; other site 644042004926 ATP binding site [chemical binding]; other site 644042004927 Q-loop/lid; other site 644042004928 ABC transporter signature motif; other site 644042004929 Walker B; other site 644042004930 D-loop; other site 644042004931 H-loop/switch region; other site 644042004932 Predicted transcriptional regulators [Transcription]; Region: COG1725 644042004933 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042004934 DNA-binding site [nucleotide binding]; DNA binding site 644042004935 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 644042004936 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 644042004937 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 644042004938 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644042004939 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 644042004940 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644042004941 DNA binding residues [nucleotide binding] 644042004942 DNA primase; Validated; Region: dnaG; PRK05667 644042004943 CHC2 zinc finger; Region: zf-CHC2; pfam01807 644042004944 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 644042004945 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 644042004946 active site 644042004947 metal binding site [ion binding]; metal-binding site 644042004948 interdomain interaction site; other site 644042004949 PE-PPE domain; Region: PE-PPE; pfam08237 644042004950 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 644042004951 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 644042004952 dimer interface [polypeptide binding]; other site 644042004953 motif 1; other site 644042004954 active site 644042004955 motif 2; other site 644042004956 motif 3; other site 644042004957 DNA repair protein RecO; Region: reco; TIGR00613 644042004958 Recombination protein O N terminal; Region: RecO_N; pfam11967 644042004959 Recombination protein O C terminal; Region: RecO_C; pfam02565 644042004960 GTPase Era; Reviewed; Region: era; PRK00089 644042004961 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 644042004962 G1 box; other site 644042004963 GTP/Mg2+ binding site [chemical binding]; other site 644042004964 Switch I region; other site 644042004965 G2 box; other site 644042004966 Switch II region; other site 644042004967 G3 box; other site 644042004968 G4 box; other site 644042004969 G5 box; other site 644042004970 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 644042004971 metal-binding heat shock protein; Provisional; Region: PRK00016 644042004972 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 644042004973 PhoH-like protein; Region: PhoH; pfam02562 644042004974 Yqey-like protein; Region: YqeY; pfam09424 644042004975 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 644042004976 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 644042004977 short chain dehydrogenase; Provisional; Region: PRK07041 644042004978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644042004979 NAD(P) binding site [chemical binding]; other site 644042004980 active site 644042004981 endonuclease IV; Provisional; Region: PRK01060 644042004982 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 644042004983 AP (apurinic/apyrimidinic) site pocket; other site 644042004984 DNA interaction; other site 644042004985 Metal-binding active site; metal-binding site 644042004986 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 644042004987 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 644042004988 Uncharacterized conserved protein [Function unknown]; Region: COG1284 644042004989 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 644042004990 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 644042004991 methionine sulfoxide reductase A; Provisional; Region: PRK14054 644042004992 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 644042004993 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 644042004994 dimer interface [polypeptide binding]; other site 644042004995 anticodon binding site; other site 644042004996 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 644042004997 homodimer interface [polypeptide binding]; other site 644042004998 motif 1; other site 644042004999 active site 644042005000 motif 2; other site 644042005001 GAD domain; Region: GAD; pfam02938 644042005002 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 644042005003 active site 644042005004 motif 3; other site 644042005005 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 644042005006 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 644042005007 dimer interface [polypeptide binding]; other site 644042005008 motif 1; other site 644042005009 active site 644042005010 motif 2; other site 644042005011 motif 3; other site 644042005012 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 644042005013 anticodon binding site; other site 644042005014 Bacterial SH3 domain; Region: SH3_3; pfam08239 644042005015 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 644042005016 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 644042005017 active site 644042005018 metal binding site [ion binding]; metal-binding site 644042005019 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 644042005020 Phosphotransferase enzyme family; Region: APH; pfam01636 644042005021 active site 644042005022 ATP binding site [chemical binding]; other site 644042005023 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 644042005024 substrate binding site [chemical binding]; other site 644042005025 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 644042005026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042005027 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 644042005028 putative active site [active] 644042005029 dimerization interface [polypeptide binding]; other site 644042005030 putative tRNAtyr binding site [nucleotide binding]; other site 644042005031 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 644042005032 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644042005033 Zn2+ binding site [ion binding]; other site 644042005034 Mg2+ binding site [ion binding]; other site 644042005035 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 644042005036 synthetase active site [active] 644042005037 NTP binding site [chemical binding]; other site 644042005038 metal binding site [ion binding]; metal-binding site 644042005039 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 644042005040 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 644042005041 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 644042005042 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 644042005043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644042005044 S-adenosylmethionine binding site [chemical binding]; other site 644042005045 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 644042005046 active site 644042005047 DNA binding site [nucleotide binding] 644042005048 GTP-binding protein LepA; Provisional; Region: PRK05433 644042005049 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 644042005050 G1 box; other site 644042005051 putative GEF interaction site [polypeptide binding]; other site 644042005052 GTP/Mg2+ binding site [chemical binding]; other site 644042005053 Switch I region; other site 644042005054 G2 box; other site 644042005055 G3 box; other site 644042005056 Switch II region; other site 644042005057 G4 box; other site 644042005058 G5 box; other site 644042005059 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 644042005060 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 644042005061 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 644042005062 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 644042005063 DltD N-terminal region; Region: DltD_N; pfam04915 644042005064 DltD central region; Region: DltD_M; pfam04918 644042005065 DltD C-terminal region; Region: DltD_C; pfam04914 644042005066 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 644042005067 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 644042005068 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 644042005069 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 644042005070 acyl-activating enzyme (AAE) consensus motif; other site 644042005071 AMP binding site [chemical binding]; other site 644042005072 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 644042005073 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 644042005074 Beta-lactamase; Region: Beta-lactamase; pfam00144 644042005075 chaperone protein DnaJ; Provisional; Region: PRK14276 644042005076 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 644042005077 HSP70 interaction site [polypeptide binding]; other site 644042005078 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 644042005079 substrate binding site [polypeptide binding]; other site 644042005080 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 644042005081 Zn binding sites [ion binding]; other site 644042005082 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 644042005083 dimer interface [polypeptide binding]; other site 644042005084 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 644042005085 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 644042005086 nucleotide binding site [chemical binding]; other site 644042005087 GrpE; Region: GrpE; pfam01025 644042005088 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 644042005089 dimer interface [polypeptide binding]; other site 644042005090 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 644042005091 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 644042005092 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 644042005093 NLE (NUC135) domain; Region: NLE; pfam08154 644042005094 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 644042005095 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 644042005096 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 644042005097 active site 644042005098 Riboflavin kinase; Region: Flavokinase; smart00904 644042005099 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 644042005100 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 644042005101 RNA binding site [nucleotide binding]; other site 644042005102 active site 644042005103 shikimate kinase; Reviewed; Region: aroK; PRK00131 644042005104 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 644042005105 ADP binding site [chemical binding]; other site 644042005106 magnesium binding site [ion binding]; other site 644042005107 putative shikimate binding site; other site 644042005108 prephenate dehydrogenase; Validated; Region: PRK06545 644042005109 prephenate dehydrogenase; Validated; Region: PRK08507 644042005110 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 644042005111 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 644042005112 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 644042005113 hinge; other site 644042005114 active site 644042005115 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 644042005116 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 644042005117 Tetramer interface [polypeptide binding]; other site 644042005118 active site 644042005119 FMN-binding site [chemical binding]; other site 644042005120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042005121 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042005122 putative substrate translocation pore; other site 644042005123 Chorismate mutase type II; Region: CM_2; pfam01817 644042005124 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 644042005125 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 644042005126 translation initiation factor IF-2; Region: IF-2; TIGR00487 644042005127 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 644042005128 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 644042005129 G1 box; other site 644042005130 putative GEF interaction site [polypeptide binding]; other site 644042005131 GTP/Mg2+ binding site [chemical binding]; other site 644042005132 Switch I region; other site 644042005133 G2 box; other site 644042005134 G3 box; other site 644042005135 Switch II region; other site 644042005136 G4 box; other site 644042005137 G5 box; other site 644042005138 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 644042005139 Translation-initiation factor 2; Region: IF-2; pfam11987 644042005140 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 644042005141 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 644042005142 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 644042005143 putative RNA binding cleft [nucleotide binding]; other site 644042005144 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 644042005145 NusA N-terminal domain; Region: NusA_N; pfam08529 644042005146 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 644042005147 RNA binding site [nucleotide binding]; other site 644042005148 homodimer interface [polypeptide binding]; other site 644042005149 NusA-like KH domain; Region: KH_5; pfam13184 644042005150 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 644042005151 G-X-X-G motif; other site 644042005152 ribosome maturation protein RimP; Reviewed; Region: PRK00092 644042005153 Sm and related proteins; Region: Sm_like; cl00259 644042005154 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 644042005155 putative oligomer interface [polypeptide binding]; other site 644042005156 putative RNA binding site [nucleotide binding]; other site 644042005157 DNA polymerase III PolC; Validated; Region: polC; PRK00448 644042005158 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 644042005159 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 644042005160 generic binding surface II; other site 644042005161 generic binding surface I; other site 644042005162 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 644042005163 active site 644042005164 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 644042005165 active site 644042005166 catalytic site [active] 644042005167 substrate binding site [chemical binding]; other site 644042005168 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 644042005169 prolyl-tRNA synthetase; Provisional; Region: PRK09194 644042005170 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 644042005171 dimer interface [polypeptide binding]; other site 644042005172 motif 1; other site 644042005173 active site 644042005174 motif 2; other site 644042005175 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 644042005176 putative deacylase active site [active] 644042005177 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 644042005178 active site 644042005179 motif 3; other site 644042005180 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 644042005181 anticodon binding site; other site 644042005182 RIP metalloprotease RseP; Region: TIGR00054 644042005183 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 644042005184 active site 644042005185 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 644042005186 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 644042005187 putative substrate binding region [chemical binding]; other site 644042005188 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 644042005189 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 644042005190 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 644042005191 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 644042005192 catalytic residue [active] 644042005193 putative FPP diphosphate binding site; other site 644042005194 putative FPP binding hydrophobic cleft; other site 644042005195 dimer interface [polypeptide binding]; other site 644042005196 putative IPP diphosphate binding site; other site 644042005197 ribosome recycling factor; Reviewed; Region: frr; PRK00083 644042005198 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 644042005199 hinge region; other site 644042005200 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 644042005201 putative nucleotide binding site [chemical binding]; other site 644042005202 uridine monophosphate binding site [chemical binding]; other site 644042005203 homohexameric interface [polypeptide binding]; other site 644042005204 elongation factor Ts; Provisional; Region: tsf; PRK09377 644042005205 UBA/TS-N domain; Region: UBA; pfam00627 644042005206 Elongation factor TS; Region: EF_TS; pfam00889 644042005207 Elongation factor TS; Region: EF_TS; pfam00889 644042005208 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 644042005209 rRNA interaction site [nucleotide binding]; other site 644042005210 S8 interaction site; other site 644042005211 putative laminin-1 binding site; other site 644042005212 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 644042005213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042005214 motif II; other site 644042005215 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 644042005216 D-lactate dehydrogenase; Validated; Region: PRK08605 644042005217 homodimer interface [polypeptide binding]; other site 644042005218 ligand binding site [chemical binding]; other site 644042005219 NAD binding site [chemical binding]; other site 644042005220 catalytic site [active] 644042005221 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 644042005222 putative active site [active] 644042005223 GIY-YIG motif/motif A; other site 644042005224 putative metal binding site [ion binding]; other site 644042005225 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 644042005226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644042005227 S-adenosylmethionine binding site [chemical binding]; other site 644042005228 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 644042005229 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 644042005230 putative acyl-acceptor binding pocket; other site 644042005231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 644042005232 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 644042005233 LexA repressor; Validated; Region: PRK00215 644042005234 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644042005235 putative DNA binding site [nucleotide binding]; other site 644042005236 putative Zn2+ binding site [ion binding]; other site 644042005237 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 644042005238 Catalytic site [active] 644042005239 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 644042005240 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 644042005241 dimer interface [polypeptide binding]; other site 644042005242 active site 644042005243 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 644042005244 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 644042005245 Ligand binding site; other site 644042005246 Putative Catalytic site; other site 644042005247 DXD motif; other site 644042005248 Short C-terminal domain; Region: SHOCT; pfam09851 644042005249 Short C-terminal domain; Region: SHOCT; pfam09851 644042005250 Integrase core domain; Region: rve_2; pfam13333 644042005251 HTH-like domain; Region: HTH_21; pfam13276 644042005252 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 644042005253 Int/Topo IB signature motif; other site 644042005254 potential frameshift: common BLAST hit: gi|28378706|ref|NP_785598.1| methyltransferase () 644042005255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 644042005256 hypothetical protein; Provisional; Region: PRK00967 644042005257 H+ Antiporter protein; Region: 2A0121; TIGR00900 644042005258 Helix-turn-helix domain; Region: HTH_20; pfam12840 644042005259 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644042005260 active site 644042005261 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 644042005262 DHH family; Region: DHH; pfam01368 644042005263 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 644042005264 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 644042005265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644042005266 NAD(P) binding site [chemical binding]; other site 644042005267 active site 644042005268 ribonuclease Z; Region: RNase_Z; TIGR02651 644042005269 GTPase CgtA; Reviewed; Region: obgE; PRK12297 644042005270 GTP1/OBG; Region: GTP1_OBG; pfam01018 644042005271 Obg GTPase; Region: Obg; cd01898 644042005272 G1 box; other site 644042005273 GTP/Mg2+ binding site [chemical binding]; other site 644042005274 Switch I region; other site 644042005275 G2 box; other site 644042005276 G3 box; other site 644042005277 Switch II region; other site 644042005278 G4 box; other site 644042005279 G5 box; other site 644042005280 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 644042005281 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 644042005282 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 644042005283 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 644042005284 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 644042005285 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 644042005286 putative substrate binding site [chemical binding]; other site 644042005287 putative ATP binding site [chemical binding]; other site 644042005288 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 644042005289 active site 644042005290 phosphorylation site [posttranslational modification] 644042005291 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 644042005292 active site 644042005293 P-loop; other site 644042005294 phosphorylation site [posttranslational modification] 644042005295 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 644042005296 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 644042005297 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 644042005298 active site 644042005299 metal binding site [ion binding]; metal-binding site 644042005300 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 644042005301 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 644042005302 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 644042005303 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 644042005304 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 644042005305 active site 644042005306 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644042005307 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 644042005308 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644042005309 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 644042005310 putative ADP-binding pocket [chemical binding]; other site 644042005311 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 644042005312 Bacterial sugar transferase; Region: Bac_transf; pfam02397 644042005313 potential frameshift: common BLAST hit: gi|28378727|ref|NP_785619.1| UDP-glucose 4-epimerase 644042005314 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 644042005315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644042005316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644042005317 NAD(P) binding site [chemical binding]; other site 644042005318 active site 644042005319 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 644042005320 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 644042005321 active site 644042005322 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 644042005323 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 644042005324 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 644042005325 Chain length determinant protein; Region: Wzz; cl15801 644042005326 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 644042005327 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 644042005328 GIY-YIG motif/motif A; other site 644042005329 active site 644042005330 catalytic site [active] 644042005331 putative DNA binding site [nucleotide binding]; other site 644042005332 metal binding site [ion binding]; metal-binding site 644042005333 UvrB/uvrC motif; Region: UVR; pfam02151 644042005334 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 644042005335 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 644042005336 DNA binding site [nucleotide binding] 644042005337 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 644042005338 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 644042005339 Walker A/P-loop; other site 644042005340 ATP binding site [chemical binding]; other site 644042005341 Q-loop/lid; other site 644042005342 ABC transporter signature motif; other site 644042005343 Walker B; other site 644042005344 D-loop; other site 644042005345 H-loop/switch region; other site 644042005346 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644042005347 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 644042005348 substrate binding pocket [chemical binding]; other site 644042005349 membrane-bound complex binding site; other site 644042005350 hinge residues; other site 644042005351 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 644042005352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042005353 dimer interface [polypeptide binding]; other site 644042005354 conserved gate region; other site 644042005355 putative PBP binding loops; other site 644042005356 ABC-ATPase subunit interface; other site 644042005357 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 644042005358 putative metal binding site [ion binding]; other site 644042005359 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 644042005360 G1 box; other site 644042005361 GTP/Mg2+ binding site [chemical binding]; other site 644042005362 Switch I region; other site 644042005363 G2 box; other site 644042005364 G3 box; other site 644042005365 Switch II region; other site 644042005366 G4 box; other site 644042005367 G5 box; other site 644042005368 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 644042005369 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 644042005370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042005371 Walker A motif; other site 644042005372 ATP binding site [chemical binding]; other site 644042005373 Walker B motif; other site 644042005374 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 644042005375 trigger factor; Provisional; Region: tig; PRK01490 644042005376 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 644042005377 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 644042005378 elongation factor Tu; Reviewed; Region: PRK00049 644042005379 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 644042005380 G1 box; other site 644042005381 GEF interaction site [polypeptide binding]; other site 644042005382 GTP/Mg2+ binding site [chemical binding]; other site 644042005383 Switch I region; other site 644042005384 G2 box; other site 644042005385 G3 box; other site 644042005386 Switch II region; other site 644042005387 G4 box; other site 644042005388 G5 box; other site 644042005389 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 644042005390 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 644042005391 Antibiotic Binding Site [chemical binding]; other site 644042005392 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 644042005393 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 644042005394 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 644042005395 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 644042005396 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 644042005397 dimer interface [polypeptide binding]; other site 644042005398 active site 644042005399 catalytic residue [active] 644042005400 drug efflux system protein MdtG; Provisional; Region: PRK09874 644042005401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042005402 putative substrate translocation pore; other site 644042005403 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 644042005404 16S/18S rRNA binding site [nucleotide binding]; other site 644042005405 S13e-L30e interaction site [polypeptide binding]; other site 644042005406 25S rRNA binding site [nucleotide binding]; other site 644042005407 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 644042005408 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 644042005409 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 644042005410 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 644042005411 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 644042005412 Competence protein; Region: Competence; pfam03772 644042005413 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 644042005414 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 644042005415 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 644042005416 catalytic motif [active] 644042005417 Zn binding site [ion binding]; other site 644042005418 Helix-hairpin-helix motif; Region: HHH; pfam00633 644042005419 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 644042005420 SLBB domain; Region: SLBB; pfam10531 644042005421 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 644042005422 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 644042005423 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 644042005424 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 644042005425 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 644042005426 active site 644042005427 (T/H)XGH motif; other site 644042005428 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 644042005429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644042005430 S-adenosylmethionine binding site [chemical binding]; other site 644042005431 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 644042005432 pyruvate carboxylase; Reviewed; Region: PRK12999 644042005433 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 644042005434 ATP-grasp domain; Region: ATP-grasp_4; cl17255 644042005435 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 644042005436 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 644042005437 active site 644042005438 catalytic residues [active] 644042005439 metal binding site [ion binding]; metal-binding site 644042005440 homodimer binding site [polypeptide binding]; other site 644042005441 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 644042005442 carboxyltransferase (CT) interaction site; other site 644042005443 biotinylation site [posttranslational modification]; other site 644042005444 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 644042005445 conserved hypothetical integral membrane protein; Region: TIGR03766 644042005446 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 644042005447 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 644042005448 DXD motif; other site 644042005449 exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110 644042005450 Firmicu-CTERM domain; Region: Firmicu_CTERM; TIGR04145 644042005451 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 644042005452 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 644042005453 G1 box; other site 644042005454 putative GEF interaction site [polypeptide binding]; other site 644042005455 GTP/Mg2+ binding site [chemical binding]; other site 644042005456 Switch I region; other site 644042005457 G2 box; other site 644042005458 G3 box; other site 644042005459 Switch II region; other site 644042005460 G4 box; other site 644042005461 G5 box; other site 644042005462 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 644042005463 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 644042005464 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 644042005465 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 644042005466 active site 644042005467 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 644042005468 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 644042005469 substrate binding site [chemical binding]; other site 644042005470 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 644042005471 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 644042005472 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644042005473 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 644042005474 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 644042005475 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 644042005476 E3 interaction surface; other site 644042005477 lipoyl attachment site [posttranslational modification]; other site 644042005478 e3 binding domain; Region: E3_binding; pfam02817 644042005479 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 644042005480 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 644042005481 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 644042005482 alpha subunit interface [polypeptide binding]; other site 644042005483 TPP binding site [chemical binding]; other site 644042005484 heterodimer interface [polypeptide binding]; other site 644042005485 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 644042005486 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 644042005487 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 644042005488 TPP-binding site [chemical binding]; other site 644042005489 heterodimer interface [polypeptide binding]; other site 644042005490 tetramer interface [polypeptide binding]; other site 644042005491 phosphorylation loop region [posttranslational modification] 644042005492 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 644042005493 active site 644042005494 catalytic residues [active] 644042005495 metal binding site [ion binding]; metal-binding site 644042005496 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 644042005497 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 644042005498 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 644042005499 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 644042005500 potential frameshift: common BLAST hit: gi|28378772|ref|NP_785664.1| transcription regulator 644042005501 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 644042005502 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 644042005503 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644042005504 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644042005505 NlpC/P60 family; Region: NLPC_P60; pfam00877 644042005506 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 644042005507 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 644042005508 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 644042005509 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644042005510 active site 644042005511 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 644042005512 AAA domain; Region: AAA_30; pfam13604 644042005513 Family description; Region: UvrD_C_2; pfam13538 644042005514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 644042005515 binding surface 644042005516 TPR motif; other site 644042005517 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644042005518 catalytic core [active] 644042005519 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 644042005520 WxL domain surface cell wall-binding; Region: WxL; pfam13731 644042005521 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 644042005522 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 644042005523 WxL domain surface cell wall-binding; Region: WxL; pfam13731 644042005524 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 644042005525 TrkA-N domain; Region: TrkA_N; pfam02254 644042005526 TrkA-C domain; Region: TrkA_C; pfam02080 644042005527 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 644042005528 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 644042005529 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 644042005530 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 644042005531 Putative amino acid metabolism; Region: DUF1831; pfam08866 644042005532 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 644042005533 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 644042005534 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644042005535 catalytic residue [active] 644042005536 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 644042005537 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 644042005538 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 644042005539 dimer interface [polypeptide binding]; other site 644042005540 ADP-ribose binding site [chemical binding]; other site 644042005541 active site 644042005542 nudix motif; other site 644042005543 metal binding site [ion binding]; metal-binding site 644042005544 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 644042005545 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 644042005546 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 644042005547 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 644042005548 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 644042005549 active site 644042005550 HIGH motif; other site 644042005551 nucleotide binding site [chemical binding]; other site 644042005552 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 644042005553 active site 644042005554 KMSKS motif; other site 644042005555 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 644042005556 tRNA binding surface [nucleotide binding]; other site 644042005557 anticodon binding site; other site 644042005558 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 644042005559 DivIVA protein; Region: DivIVA; pfam05103 644042005560 DivIVA domain; Region: DivI1A_domain; TIGR03544 644042005561 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 644042005562 YGGT family; Region: YGGT; pfam02325 644042005563 Protein of unknown function (DUF552); Region: DUF552; cl00775 644042005564 cell division protein FtsZ; Validated; Region: PRK09330 644042005565 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 644042005566 nucleotide binding site [chemical binding]; other site 644042005567 SulA interaction site; other site 644042005568 cell division protein FtsA; Region: ftsA; TIGR01174 644042005569 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 644042005570 nucleotide binding site [chemical binding]; other site 644042005571 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 644042005572 Cell division protein FtsA; Region: FtsA; pfam14450 644042005573 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 644042005574 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 644042005575 Cell division protein FtsQ; Region: FtsQ; pfam03799 644042005576 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 644042005577 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 644042005578 active site 644042005579 homodimer interface [polypeptide binding]; other site 644042005580 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 644042005581 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 644042005582 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644042005583 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644042005584 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 644042005585 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 644042005586 Mg++ binding site [ion binding]; other site 644042005587 putative catalytic motif [active] 644042005588 putative substrate binding site [chemical binding]; other site 644042005589 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 644042005590 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 644042005591 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 644042005592 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 644042005593 cell division protein FtsL; Region: ftsL_broad; TIGR02209 644042005594 MraW methylase family; Region: Methyltransf_5; pfam01795 644042005595 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 644042005596 cell division protein MraZ; Reviewed; Region: PRK00326 644042005597 MraZ protein; Region: MraZ; pfam02381 644042005598 MraZ protein; Region: MraZ; pfam02381 644042005599 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 644042005600 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 644042005601 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 644042005602 Cl binding site [ion binding]; other site 644042005603 oligomer interface [polypeptide binding]; other site 644042005604 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 644042005605 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 644042005606 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 644042005607 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 644042005608 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 644042005609 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 644042005610 NADH(P)-binding; Region: NAD_binding_10; pfam13460 644042005611 NAD binding site [chemical binding]; other site 644042005612 substrate binding site [chemical binding]; other site 644042005613 putative active site [active] 644042005614 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 644042005615 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 644042005616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644042005617 S-adenosylmethionine binding site [chemical binding]; other site 644042005618 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 644042005619 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 644042005620 Domain of unknown function DUF20; Region: UPF0118; pfam01594 644042005621 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 644042005622 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 644042005623 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 644042005624 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 644042005625 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 644042005626 active site 644042005627 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 644042005628 ATP-NAD kinase; Region: NAD_kinase; pfam01513 644042005629 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 644042005630 synthetase active site [active] 644042005631 NTP binding site [chemical binding]; other site 644042005632 metal binding site [ion binding]; metal-binding site 644042005633 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 644042005634 catalytic residues [active] 644042005635 oligoendopeptidase F; Region: pepF; TIGR00181 644042005636 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 644042005637 active site 644042005638 Zn binding site [ion binding]; other site 644042005639 Competence protein CoiA-like family; Region: CoiA; cl11541 644042005640 adaptor protein; Provisional; Region: PRK02315 644042005641 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 644042005642 ArsC family; Region: ArsC; pfam03960 644042005643 putative catalytic residues [active] 644042005644 thiol/disulfide switch; other site 644042005645 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 644042005646 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 644042005647 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 644042005648 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 644042005649 RNA binding site [nucleotide binding]; other site 644042005650 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 644042005651 active site 644042005652 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 644042005653 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 644042005654 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 644042005655 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 644042005656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042005657 active site 644042005658 motif I; other site 644042005659 motif II; other site 644042005660 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042005661 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 644042005662 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 644042005663 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 644042005664 active site 644042005665 metal binding site [ion binding]; metal-binding site 644042005666 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 644042005667 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 644042005668 putative active site [active] 644042005669 putative metal binding site [ion binding]; other site 644042005670 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 644042005671 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 644042005672 propionate/acetate kinase; Provisional; Region: PRK12379 644042005673 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 644042005674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644042005675 S-adenosylmethionine binding site [chemical binding]; other site 644042005676 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 644042005677 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 644042005678 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 644042005679 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 644042005680 Type II/IV secretion system protein; Region: T2SE; pfam00437 644042005681 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 644042005682 Walker A motif; other site 644042005683 ATP binding site [chemical binding]; other site 644042005684 Walker B motif; other site 644042005685 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 644042005686 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 644042005687 substrate binding site [chemical binding]; other site 644042005688 dimer interface [polypeptide binding]; other site 644042005689 ATP binding site [chemical binding]; other site 644042005690 hypothetical protein; Validated; Region: PRK00110 644042005691 DsrE/DsrF-like family; Region: DrsE; cl00672 644042005692 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 644042005693 catabolite control protein A; Region: ccpA; TIGR01481 644042005694 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644042005695 DNA binding site [nucleotide binding] 644042005696 domain linker motif; other site 644042005697 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 644042005698 dimerization interface [polypeptide binding]; other site 644042005699 effector binding site; other site 644042005700 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 644042005701 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 644042005702 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 644042005703 active site 644042005704 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 644042005705 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 644042005706 DNA binding residues [nucleotide binding] 644042005707 putative dimer interface [polypeptide binding]; other site 644042005708 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 644042005709 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 644042005710 Mechanosensitive ion channel; Region: MS_channel; pfam00924 644042005711 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 644042005712 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 644042005713 metal binding site [ion binding]; metal-binding site 644042005714 putative dimer interface [polypeptide binding]; other site 644042005715 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 644042005716 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 644042005717 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 644042005718 active site 644042005719 trimer interface [polypeptide binding]; other site 644042005720 substrate binding site [chemical binding]; other site 644042005721 CoA binding site [chemical binding]; other site 644042005722 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 644042005723 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 644042005724 active site 644042005725 metal binding site [ion binding]; metal-binding site 644042005726 homotetramer interface [polypeptide binding]; other site 644042005727 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 644042005728 active site 644042005729 dimerization interface [polypeptide binding]; other site 644042005730 glutamate racemase; Provisional; Region: PRK00865 644042005731 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 644042005732 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 644042005733 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 644042005734 catalytic residues [active] 644042005735 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 644042005736 MutS domain III; Region: MutS_III; pfam05192 644042005737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042005738 Walker A/P-loop; other site 644042005739 ATP binding site [chemical binding]; other site 644042005740 Q-loop/lid; other site 644042005741 ABC transporter signature motif; other site 644042005742 Walker B; other site 644042005743 D-loop; other site 644042005744 H-loop/switch region; other site 644042005745 Smr domain; Region: Smr; pfam01713 644042005746 Cell division protein ZapA; Region: ZapA; cl01146 644042005747 hypothetical protein; Provisional; Region: PRK13678 644042005748 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 644042005749 hypothetical protein; Provisional; Region: PRK05473 644042005750 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 644042005751 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 644042005752 motif 1; other site 644042005753 active site 644042005754 motif 2; other site 644042005755 motif 3; other site 644042005756 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 644042005757 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 644042005758 DEAD-like helicases superfamily; Region: DEXDc; smart00487 644042005759 ATP binding site [chemical binding]; other site 644042005760 Mg++ binding site [ion binding]; other site 644042005761 motif III; other site 644042005762 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644042005763 nucleotide binding region [chemical binding]; other site 644042005764 ATP-binding site [chemical binding]; other site 644042005765 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 644042005766 DHH family; Region: DHH; pfam01368 644042005767 DHHA1 domain; Region: DHHA1; pfam02272 644042005768 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 644042005769 active site 644042005770 DNA polymerase IV; Validated; Region: PRK02406 644042005771 DNA binding site [nucleotide binding] 644042005772 Preprotein translocase subunit; Region: YajC; pfam02699 644042005773 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 644042005774 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 644042005775 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 644042005776 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 644042005777 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 644042005778 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042005779 Walker A motif; other site 644042005780 ATP binding site [chemical binding]; other site 644042005781 Walker B motif; other site 644042005782 arginine finger; other site 644042005783 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 644042005784 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 644042005785 RuvA N terminal domain; Region: RuvA_N; pfam01330 644042005786 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 644042005787 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 644042005788 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 644042005789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 644042005790 ATP binding site [chemical binding]; other site 644042005791 Mg2+ binding site [ion binding]; other site 644042005792 G-X-G motif; other site 644042005793 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 644042005794 ATP binding site [chemical binding]; other site 644042005795 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 644042005796 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 644042005797 MutS domain I; Region: MutS_I; pfam01624 644042005798 MutS domain II; Region: MutS_II; pfam05188 644042005799 MutS domain III; Region: MutS_III; pfam05192 644042005800 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 644042005801 Walker A/P-loop; other site 644042005802 ATP binding site [chemical binding]; other site 644042005803 Q-loop/lid; other site 644042005804 ABC transporter signature motif; other site 644042005805 Walker B; other site 644042005806 D-loop; other site 644042005807 H-loop/switch region; other site 644042005808 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 644042005809 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 644042005810 putative active site [active] 644042005811 metal binding site [ion binding]; metal-binding site 644042005812 homodimer binding site [polypeptide binding]; other site 644042005813 ribonuclease Y; Region: RNase_Y; TIGR03319 644042005814 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644042005815 Zn2+ binding site [ion binding]; other site 644042005816 Mg2+ binding site [ion binding]; other site 644042005817 recombinase A; Provisional; Region: recA; PRK09354 644042005818 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 644042005819 hexamer interface [polypeptide binding]; other site 644042005820 Walker A motif; other site 644042005821 ATP binding site [chemical binding]; other site 644042005822 Walker B motif; other site 644042005823 competence damage-inducible protein A; Provisional; Region: PRK00549 644042005824 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 644042005825 putative MPT binding site; other site 644042005826 Competence-damaged protein; Region: CinA; pfam02464 644042005827 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 644042005828 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 644042005829 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042005830 non-specific DNA binding site [nucleotide binding]; other site 644042005831 salt bridge; other site 644042005832 sequence-specific DNA binding site [nucleotide binding]; other site 644042005833 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 644042005834 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 644042005835 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 644042005836 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 644042005837 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 644042005838 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 644042005839 aspartate kinase; Reviewed; Region: PRK09034 644042005840 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 644042005841 putative catalytic residues [active] 644042005842 putative nucleotide binding site [chemical binding]; other site 644042005843 putative aspartate binding site [chemical binding]; other site 644042005844 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 644042005845 allosteric regulatory residue; other site 644042005846 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 644042005847 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 644042005848 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644042005849 substrate binding pocket [chemical binding]; other site 644042005850 membrane-bound complex binding site; other site 644042005851 hinge residues; other site 644042005852 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644042005853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042005854 Walker A/P-loop; other site 644042005855 ATP binding site [chemical binding]; other site 644042005856 Q-loop/lid; other site 644042005857 ABC transporter signature motif; other site 644042005858 Walker B; other site 644042005859 D-loop; other site 644042005860 H-loop/switch region; other site 644042005861 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 644042005862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042005863 dimer interface [polypeptide binding]; other site 644042005864 conserved gate region; other site 644042005865 putative PBP binding loops; other site 644042005866 ABC-ATPase subunit interface; other site 644042005867 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 644042005868 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 644042005869 Switch I; other site 644042005870 Switch II; other site 644042005871 septum formation inhibitor; Reviewed; Region: minC; PRK00513 644042005872 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 644042005873 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 644042005874 rod shape-determining protein MreC; Provisional; Region: PRK13922 644042005875 rod shape-determining protein MreC; Region: MreC; pfam04085 644042005876 rod shape-determining protein MreB; Provisional; Region: PRK13927 644042005877 MreB and similar proteins; Region: MreB_like; cd10225 644042005878 nucleotide binding site [chemical binding]; other site 644042005879 Mg binding site [ion binding]; other site 644042005880 putative protofilament interaction site [polypeptide binding]; other site 644042005881 RodZ interaction site [polypeptide binding]; other site 644042005882 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 644042005883 MPN+ (JAMM) motif; other site 644042005884 Zinc-binding site [ion binding]; other site 644042005885 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 644042005886 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644042005887 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644042005888 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 644042005889 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 644042005890 active site 644042005891 HIGH motif; other site 644042005892 nucleotide binding site [chemical binding]; other site 644042005893 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 644042005894 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 644042005895 active site 644042005896 KMSKS motif; other site 644042005897 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 644042005898 tRNA binding surface [nucleotide binding]; other site 644042005899 anticodon binding site; other site 644042005900 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 644042005901 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 644042005902 dimer interface [polypeptide binding]; other site 644042005903 catalytic triad [active] 644042005904 peroxidatic and resolving cysteines [active] 644042005905 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 644042005906 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 644042005907 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 644042005908 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 644042005909 Ligand Binding Site [chemical binding]; other site 644042005910 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 644042005911 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 644042005912 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644042005913 catalytic residue [active] 644042005914 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 644042005915 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 644042005916 GAF domain; Region: GAF_2; pfam13185 644042005917 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 644042005918 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 644042005919 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644042005920 RNA binding surface [nucleotide binding]; other site 644042005921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 644042005922 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 644042005923 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 644042005924 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 644042005925 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644042005926 dimerization interface [polypeptide binding]; other site 644042005927 putative DNA binding site [nucleotide binding]; other site 644042005928 putative Zn2+ binding site [ion binding]; other site 644042005929 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 644042005930 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 644042005931 recombination factor protein RarA; Reviewed; Region: PRK13342 644042005932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042005933 Walker A motif; other site 644042005934 ATP binding site [chemical binding]; other site 644042005935 Walker B motif; other site 644042005936 arginine finger; other site 644042005937 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 644042005938 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644042005939 Ligand Binding Site [chemical binding]; other site 644042005940 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 644042005941 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 644042005942 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042005943 non-specific DNA binding site [nucleotide binding]; other site 644042005944 salt bridge; other site 644042005945 sequence-specific DNA binding site [nucleotide binding]; other site 644042005946 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 644042005947 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 644042005948 putative active site [active] 644042005949 catalytic site [active] 644042005950 putative metal binding site [ion binding]; other site 644042005951 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 644042005952 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 644042005953 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 644042005954 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 644042005955 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 644042005956 putative NAD(P) binding site [chemical binding]; other site 644042005957 dimer interface [polypeptide binding]; other site 644042005958 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 644042005959 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 644042005960 tetramer (dimer of dimers) interface [polypeptide binding]; other site 644042005961 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 644042005962 NAD binding site [chemical binding]; other site 644042005963 dimer interface [polypeptide binding]; other site 644042005964 substrate binding site [chemical binding]; other site 644042005965 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 644042005966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042005967 dimer interface [polypeptide binding]; other site 644042005968 conserved gate region; other site 644042005969 ABC-ATPase subunit interface; other site 644042005970 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 644042005971 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 644042005972 Walker A/P-loop; other site 644042005973 ATP binding site [chemical binding]; other site 644042005974 Q-loop/lid; other site 644042005975 ABC transporter signature motif; other site 644042005976 Walker B; other site 644042005977 D-loop; other site 644042005978 H-loop/switch region; other site 644042005979 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 644042005980 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 644042005981 lipoyl attachment site [posttranslational modification]; other site 644042005982 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 644042005983 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 644042005984 hypothetical protein; Validated; Region: PRK00041 644042005985 rod shape-determining protein MreB; Provisional; Region: PRK13930 644042005986 MreB and similar proteins; Region: MreB_like; cd10225 644042005987 nucleotide binding site [chemical binding]; other site 644042005988 Mg binding site [ion binding]; other site 644042005989 putative protofilament interaction site [polypeptide binding]; other site 644042005990 RodZ interaction site [polypeptide binding]; other site 644042005991 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 644042005992 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 644042005993 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 644042005994 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 644042005995 hinge; other site 644042005996 active site 644042005997 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 644042005998 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 644042005999 gamma subunit interface [polypeptide binding]; other site 644042006000 epsilon subunit interface [polypeptide binding]; other site 644042006001 LBP interface [polypeptide binding]; other site 644042006002 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 644042006003 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 644042006004 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 644042006005 alpha subunit interaction interface [polypeptide binding]; other site 644042006006 Walker A motif; other site 644042006007 ATP binding site [chemical binding]; other site 644042006008 Walker B motif; other site 644042006009 inhibitor binding site; inhibition site 644042006010 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 644042006011 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 644042006012 core domain interface [polypeptide binding]; other site 644042006013 delta subunit interface [polypeptide binding]; other site 644042006014 epsilon subunit interface [polypeptide binding]; other site 644042006015 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 644042006016 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 644042006017 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 644042006018 beta subunit interaction interface [polypeptide binding]; other site 644042006019 Walker A motif; other site 644042006020 ATP binding site [chemical binding]; other site 644042006021 Walker B motif; other site 644042006022 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 644042006023 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 644042006024 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 644042006025 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 644042006026 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 644042006027 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 644042006028 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 644042006029 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 644042006030 uracil transporter; Provisional; Region: PRK10720 644042006031 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644042006032 active site 644042006033 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 644042006034 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 644042006035 dimer interface [polypeptide binding]; other site 644042006036 active site 644042006037 glycine-pyridoxal phosphate binding site [chemical binding]; other site 644042006038 folate binding site [chemical binding]; other site 644042006039 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 644042006040 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 644042006041 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 644042006042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644042006043 S-adenosylmethionine binding site [chemical binding]; other site 644042006044 peptide chain release factor 1; Validated; Region: prfA; PRK00591 644042006045 This domain is found in peptide chain release factors; Region: PCRF; smart00937 644042006046 RF-1 domain; Region: RF-1; pfam00472 644042006047 thymidine kinase; Provisional; Region: PRK04296 644042006048 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 644042006049 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644042006050 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 644042006051 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 644042006052 catalytic triad [active] 644042006053 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 644042006054 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 644042006055 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 644042006056 Beta-lactamase; Region: Beta-lactamase; pfam00144 644042006057 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 644042006058 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 644042006059 homodimer interface [polypeptide binding]; other site 644042006060 substrate-cofactor binding pocket; other site 644042006061 catalytic residue [active] 644042006062 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644042006063 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644042006064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042006065 Walker A/P-loop; other site 644042006066 ATP binding site [chemical binding]; other site 644042006067 Q-loop/lid; other site 644042006068 ABC transporter signature motif; other site 644042006069 Walker B; other site 644042006070 D-loop; other site 644042006071 H-loop/switch region; other site 644042006072 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644042006073 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644042006074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042006075 Walker A/P-loop; other site 644042006076 ATP binding site [chemical binding]; other site 644042006077 Q-loop/lid; other site 644042006078 ABC transporter signature motif; other site 644042006079 Walker B; other site 644042006080 D-loop; other site 644042006081 H-loop/switch region; other site 644042006082 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 644042006083 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 644042006084 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 644042006085 putative active site [active] 644042006086 putative metal binding site [ion binding]; other site 644042006087 Transcriptional regulators [Transcription]; Region: MarR; COG1846 644042006088 MarR family; Region: MarR_2; pfam12802 644042006089 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 644042006090 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 644042006091 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042006092 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042006093 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042006094 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042006095 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042006096 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042006097 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644042006098 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644042006099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042006100 Walker A/P-loop; other site 644042006101 ATP binding site [chemical binding]; other site 644042006102 Q-loop/lid; other site 644042006103 ABC transporter signature motif; other site 644042006104 Walker B; other site 644042006105 D-loop; other site 644042006106 H-loop/switch region; other site 644042006107 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 644042006108 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 644042006109 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644042006110 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644042006111 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 644042006112 Walker A/P-loop; other site 644042006113 ATP binding site [chemical binding]; other site 644042006114 Q-loop/lid; other site 644042006115 ABC transporter signature motif; other site 644042006116 Walker B; other site 644042006117 D-loop; other site 644042006118 H-loop/switch region; other site 644042006119 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 644042006120 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 644042006121 FtsX-like permease family; Region: FtsX; pfam02687 644042006122 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 644042006123 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 644042006124 active site 644042006125 dimer interface [polypeptide binding]; other site 644042006126 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 644042006127 dimer interface [polypeptide binding]; other site 644042006128 active site 644042006129 Sugar transport protein; Region: Sugar_transport; pfam06800 644042006130 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 644042006131 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 644042006132 putative RNA binding site [nucleotide binding]; other site 644042006133 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 644042006134 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644042006135 dimerization interface [polypeptide binding]; other site 644042006136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644042006137 dimer interface [polypeptide binding]; other site 644042006138 phosphorylation site [posttranslational modification] 644042006139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644042006140 ATP binding site [chemical binding]; other site 644042006141 Mg2+ binding site [ion binding]; other site 644042006142 G-X-G motif; other site 644042006143 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644042006144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644042006145 active site 644042006146 phosphorylation site [posttranslational modification] 644042006147 intermolecular recognition site; other site 644042006148 dimerization interface [polypeptide binding]; other site 644042006149 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644042006150 DNA binding site [nucleotide binding] 644042006151 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 644042006152 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 644042006153 EamA-like transporter family; Region: EamA; pfam00892 644042006154 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 644042006155 EamA-like transporter family; Region: EamA; cl17759 644042006156 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 644042006157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042006158 benzoate transport; Region: 2A0115; TIGR00895 644042006159 putative substrate translocation pore; other site 644042006160 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 644042006161 nudix motif; other site 644042006162 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 644042006163 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 644042006164 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 644042006165 NlpC/P60 family; Region: NLPC_P60; pfam00877 644042006166 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 644042006167 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644042006168 putative DNA binding site [nucleotide binding]; other site 644042006169 putative Zn2+ binding site [ion binding]; other site 644042006170 AsnC family; Region: AsnC_trans_reg; pfam01037 644042006171 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 644042006172 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 644042006173 metal binding site [ion binding]; metal-binding site 644042006174 active site 644042006175 I-site; other site 644042006176 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 644042006177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042006178 Walker A/P-loop; other site 644042006179 ATP binding site [chemical binding]; other site 644042006180 Q-loop/lid; other site 644042006181 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644042006182 ABC transporter signature motif; other site 644042006183 Walker B; other site 644042006184 D-loop; other site 644042006185 ABC transporter; Region: ABC_tran_2; pfam12848 644042006186 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644042006187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644042006188 Coenzyme A binding pocket [chemical binding]; other site 644042006189 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 644042006190 dimer interface [polypeptide binding]; other site 644042006191 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 644042006192 metal binding site [ion binding]; metal-binding site 644042006193 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 644042006194 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644042006195 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644042006196 active site turn [active] 644042006197 phosphorylation site [posttranslational modification] 644042006198 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 644042006199 HPr interaction site; other site 644042006200 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644042006201 active site 644042006202 phosphorylation site [posttranslational modification] 644042006203 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 644042006204 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 644042006205 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 644042006206 EDD domain protein, DegV family; Region: DegV; TIGR00762 644042006207 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 644042006208 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 644042006209 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 644042006210 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 644042006211 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 644042006212 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 644042006213 homodimer interface [polypeptide binding]; other site 644042006214 substrate-cofactor binding pocket; other site 644042006215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042006216 catalytic residue [active] 644042006217 Homoserine O-succinyltransferase; Region: HTS; pfam04204 644042006218 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 644042006219 proposed active site lysine [active] 644042006220 conserved cys residue [active] 644042006221 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 644042006222 zinc binding site [ion binding]; other site 644042006223 putative ligand binding site [chemical binding]; other site 644042006224 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 644042006225 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 644042006226 TM-ABC transporter signature motif; other site 644042006227 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 644042006228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042006229 Walker A/P-loop; other site 644042006230 ATP binding site [chemical binding]; other site 644042006231 Q-loop/lid; other site 644042006232 ABC transporter signature motif; other site 644042006233 Walker B; other site 644042006234 D-loop; other site 644042006235 H-loop/switch region; other site 644042006236 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 644042006237 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644042006238 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644042006239 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 644042006240 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 644042006241 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 644042006242 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 644042006243 maltose O-acetyltransferase; Provisional; Region: PRK10092 644042006244 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 644042006245 active site 644042006246 substrate binding site [chemical binding]; other site 644042006247 trimer interface [polypeptide binding]; other site 644042006248 CoA binding site [chemical binding]; other site 644042006249 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 644042006250 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644042006251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042006252 homodimer interface [polypeptide binding]; other site 644042006253 catalytic residue [active] 644042006254 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 644042006255 metal binding site [ion binding]; metal-binding site 644042006256 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; pfam01502 644042006257 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 644042006258 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 644042006259 substrate binding site [chemical binding]; other site 644042006260 glutamase interaction surface [polypeptide binding]; other site 644042006261 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 644042006262 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 644042006263 catalytic residues [active] 644042006264 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 644042006265 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 644042006266 putative active site [active] 644042006267 oxyanion strand; other site 644042006268 catalytic triad [active] 644042006269 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 644042006270 putative active site pocket [active] 644042006271 4-fold oligomerization interface [polypeptide binding]; other site 644042006272 metal binding residues [ion binding]; metal-binding site 644042006273 3-fold/trimer interface [polypeptide binding]; other site 644042006274 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 644042006275 histidinol dehydrogenase; Region: hisD; TIGR00069 644042006276 NAD binding site [chemical binding]; other site 644042006277 dimerization interface [polypeptide binding]; other site 644042006278 product binding site; other site 644042006279 substrate binding site [chemical binding]; other site 644042006280 zinc binding site [ion binding]; other site 644042006281 catalytic residues [active] 644042006282 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 644042006283 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 644042006284 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 644042006285 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 644042006286 dimer interface [polypeptide binding]; other site 644042006287 motif 1; other site 644042006288 active site 644042006289 motif 2; other site 644042006290 motif 3; other site 644042006291 histidinol-phosphatase; Reviewed; Region: PRK08123 644042006292 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 644042006293 active site 644042006294 dimer interface [polypeptide binding]; other site 644042006295 VanZ like family; Region: VanZ; pfam04892 644042006296 RDD family; Region: RDD; pfam06271 644042006297 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 644042006298 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 644042006299 Cl binding site [ion binding]; other site 644042006300 oligomer interface [polypeptide binding]; other site 644042006301 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 644042006302 hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK03824 644042006303 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 644042006304 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 644042006305 Peptidase M15; Region: Peptidase_M15_3; cl01194 644042006306 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 644042006307 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 644042006308 active site 644042006309 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 644042006310 Transport protein; Region: actII; TIGR00833 644042006311 Collagen binding domain; Region: Collagen_bind; pfam05737 644042006312 Cna protein B-type domain; Region: Cna_B; pfam05738 644042006313 Cna protein B-type domain; Region: Cna_B; pfam05738 644042006314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644042006315 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 644042006316 Coenzyme A binding pocket [chemical binding]; other site 644042006317 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 644042006318 Sulfatase; Region: Sulfatase; pfam00884 644042006319 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 644042006320 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 644042006321 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 644042006322 putative active site [active] 644042006323 catalytic site [active] 644042006324 putative metal binding site [ion binding]; other site 644042006325 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 644042006326 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644042006327 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644042006328 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 644042006329 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 644042006330 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 644042006331 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 644042006332 dimer interface [polypeptide binding]; other site 644042006333 FMN binding site [chemical binding]; other site 644042006334 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 644042006335 active site 644042006336 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 644042006337 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 644042006338 RNA/DNA hybrid binding site [nucleotide binding]; other site 644042006339 active site 644042006340 Sugar transport protein; Region: Sugar_transport; pfam06800 644042006341 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644042006342 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 644042006343 Protein of unknown function (DUF3206); Region: DUF3206; pfam11472 644042006344 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 644042006345 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644042006346 FeS/SAM binding site; other site 644042006347 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 644042006348 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042006349 DNA-binding site [nucleotide binding]; DNA binding site 644042006350 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 644042006351 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 644042006352 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 644042006353 dimer interface [polypeptide binding]; other site 644042006354 active site 644042006355 glycine loop; other site 644042006356 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 644042006357 Helix-turn-helix domain; Region: HTH_28; pfam13518 644042006358 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 644042006359 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 644042006360 active site 644042006361 intersubunit interactions; other site 644042006362 catalytic residue [active] 644042006363 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 644042006364 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042006365 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644042006366 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644042006367 DNA binding site [nucleotide binding] 644042006368 domain linker motif; other site 644042006369 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 644042006370 putative dimerization interface [polypeptide binding]; other site 644042006371 putative ligand binding site [chemical binding]; other site 644042006372 potential frameshift: common BLAST hit: gi|28379130|ref|NP_786022.1| transcription regulator 644042006373 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 644042006374 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 644042006375 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 644042006376 putative active site [active] 644042006377 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 644042006378 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 644042006379 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 644042006380 putative oxidoreductase; Provisional; Region: PRK10206 644042006381 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 644042006382 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 644042006383 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 644042006384 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 644042006385 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 644042006386 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 644042006387 TPP-binding site; other site 644042006388 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 644042006389 PYR/PP interface [polypeptide binding]; other site 644042006390 dimer interface [polypeptide binding]; other site 644042006391 TPP binding site [chemical binding]; other site 644042006392 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 644042006393 Isochorismatase family; Region: Isochorismatase; pfam00857 644042006394 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 644042006395 catalytic triad [active] 644042006396 conserved cis-peptide bond; other site 644042006397 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 644042006398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042006399 Walker A/P-loop; other site 644042006400 ATP binding site [chemical binding]; other site 644042006401 Q-loop/lid; other site 644042006402 ABC transporter signature motif; other site 644042006403 Walker B; other site 644042006404 D-loop; other site 644042006405 H-loop/switch region; other site 644042006406 Predicted transcriptional regulators [Transcription]; Region: COG1725 644042006407 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042006408 DNA-binding site [nucleotide binding]; DNA binding site 644042006409 Enterocin A Immunity; Region: EntA_Immun; pfam08951 644042006410 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 644042006411 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 644042006412 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 644042006413 active site 644042006414 Zn binding site [ion binding]; other site 644042006415 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644042006416 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042006417 non-specific DNA binding site [nucleotide binding]; other site 644042006418 salt bridge; other site 644042006419 sequence-specific DNA binding site [nucleotide binding]; other site 644042006420 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 644042006421 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 644042006422 PYR/PP interface [polypeptide binding]; other site 644042006423 dimer interface [polypeptide binding]; other site 644042006424 tetramer interface [polypeptide binding]; other site 644042006425 TPP binding site [chemical binding]; other site 644042006426 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 644042006427 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 644042006428 TPP-binding site [chemical binding]; other site 644042006429 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 644042006430 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 644042006431 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 644042006432 catalytic residues [active] 644042006433 cystathionine gamma-synthase; Reviewed; Region: PRK08247 644042006434 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 644042006435 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644042006436 catalytic residue [active] 644042006437 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 644042006438 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 644042006439 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 644042006440 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 644042006441 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 644042006442 Bacterial SH3 domain; Region: SH3_5; pfam08460 644042006443 Bacterial SH3 domain; Region: SH3_5; pfam08460 644042006444 Bacterial SH3 domain; Region: SH3_5; pfam08460 644042006445 Bacterial SH3 domain; Region: SH3_5; pfam08460 644042006446 Bacterial SH3 domain; Region: SH3_5; pfam08460 644042006447 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 644042006448 active pocket/dimerization site; other site 644042006449 active site 644042006450 phosphorylation site [posttranslational modification] 644042006451 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 644042006452 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 644042006453 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 644042006454 active site 644042006455 phosphorylation site [posttranslational modification] 644042006456 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 644042006457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042006458 DNA-binding site [nucleotide binding]; DNA binding site 644042006459 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 644042006460 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644042006461 Ligand Binding Site [chemical binding]; other site 644042006462 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 644042006463 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 644042006464 active site 644042006465 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042006466 non-specific DNA binding site [nucleotide binding]; other site 644042006467 salt bridge; other site 644042006468 sequence-specific DNA binding site [nucleotide binding]; other site 644042006469 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644042006470 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 644042006471 putative ADP-binding pocket [chemical binding]; other site 644042006472 putative phosphoketolase; Provisional; Region: PRK05261 644042006473 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 644042006474 TPP-binding site; other site 644042006475 XFP C-terminal domain; Region: XFP_C; pfam09363 644042006476 Putative esterase; Region: Esterase; pfam00756 644042006477 S-formylglutathione hydrolase; Region: PLN02442 644042006478 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042006479 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 644042006480 DNA-binding site [nucleotide binding]; DNA binding site 644042006481 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 644042006482 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 644042006483 putative deacylase active site [active] 644042006484 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 644042006485 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 644042006486 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 644042006487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644042006488 active site 644042006489 phosphorylation site [posttranslational modification] 644042006490 intermolecular recognition site; other site 644042006491 dimerization interface [polypeptide binding]; other site 644042006492 LytTr DNA-binding domain; Region: LytTR; pfam04397 644042006493 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 644042006494 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 644042006495 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 644042006496 putative dimer interface [polypeptide binding]; other site 644042006497 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 644042006498 Domain of unknown function DUF21; Region: DUF21; pfam01595 644042006499 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 644042006500 Transporter associated domain; Region: CorC_HlyC; smart01091 644042006501 flavoprotein NrdI; Provisional; Region: PRK02551 644042006502 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 644042006503 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 644042006504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042006505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042006506 putative substrate translocation pore; other site 644042006507 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 644042006508 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 644042006509 DNA binding residues [nucleotide binding] 644042006510 putative dimer interface [polypeptide binding]; other site 644042006511 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 644042006512 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 644042006513 putative NAD(P) binding site [chemical binding]; other site 644042006514 SdpI/YhfL protein family; Region: SdpI; pfam13630 644042006515 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 644042006516 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 644042006517 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 644042006518 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 644042006519 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042006520 DNA-binding site [nucleotide binding]; DNA binding site 644042006521 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644042006522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042006523 homodimer interface [polypeptide binding]; other site 644042006524 aromatic amino acid aminotransferase; Validated; Region: PRK07309 644042006525 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644042006526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042006527 homodimer interface [polypeptide binding]; other site 644042006528 catalytic residue [active] 644042006529 dihydrodipicolinate synthase; Region: dapA; TIGR00674 644042006530 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 644042006531 dimer interface [polypeptide binding]; other site 644042006532 active site 644042006533 catalytic residue [active] 644042006534 hypothetical protein; Provisional; Region: PRK10621 644042006535 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 644042006536 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042006537 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042006538 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644042006539 dimerization interface [polypeptide binding]; other site 644042006540 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 644042006541 NADH(P)-binding; Region: NAD_binding_10; pfam13460 644042006542 NAD(P) binding site [chemical binding]; other site 644042006543 putative active site [active] 644042006544 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 644042006545 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 644042006546 Part of AAA domain; Region: AAA_19; pfam13245 644042006547 Family description; Region: UvrD_C_2; pfam13538 644042006548 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 644042006549 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 644042006550 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 644042006551 Protein of unknown function, DUF606; Region: DUF606; pfam04657 644042006552 Protein of unknown function, DUF606; Region: DUF606; pfam04657 644042006553 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644042006554 active site 644042006555 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 644042006556 active site 644042006557 dimer interface [polypeptide binding]; other site 644042006558 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 644042006559 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 644042006560 heterodimer interface [polypeptide binding]; other site 644042006561 active site 644042006562 FMN binding site [chemical binding]; other site 644042006563 homodimer interface [polypeptide binding]; other site 644042006564 substrate binding site [chemical binding]; other site 644042006565 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 644042006566 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 644042006567 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 644042006568 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 644042006569 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 644042006570 ATP-grasp domain; Region: ATP-grasp_4; cl17255 644042006571 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 644042006572 IMP binding site; other site 644042006573 dimer interface [polypeptide binding]; other site 644042006574 interdomain contacts; other site 644042006575 partial ornithine binding site; other site 644042006576 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 644042006577 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 644042006578 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 644042006579 catalytic site [active] 644042006580 subunit interface [polypeptide binding]; other site 644042006581 dihydroorotase; Validated; Region: pyrC; PRK09357 644042006582 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 644042006583 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 644042006584 active site 644042006585 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 644042006586 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 644042006587 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 644042006588 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 644042006589 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644042006590 active site 644042006591 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 644042006592 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 644042006593 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 644042006594 xanthine permease; Region: pbuX; TIGR03173 644042006595 Sulfate transporter family; Region: Sulfate_transp; pfam00916 644042006596 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 644042006597 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 644042006598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644042006599 NAD(P) binding site [chemical binding]; other site 644042006600 active site 644042006601 EAL domain; Region: EAL; pfam00563 644042006602 N-glycosyltransferase; Provisional; Region: PRK11204 644042006603 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 644042006604 DXD motif; other site 644042006605 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 644042006606 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 644042006607 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 644042006608 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 644042006609 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 644042006610 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 644042006611 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 644042006612 purine monophosphate binding site [chemical binding]; other site 644042006613 dimer interface [polypeptide binding]; other site 644042006614 putative catalytic residues [active] 644042006615 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 644042006616 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 644042006617 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 644042006618 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 644042006619 active site 644042006620 substrate binding site [chemical binding]; other site 644042006621 cosubstrate binding site; other site 644042006622 catalytic site [active] 644042006623 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 644042006624 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 644042006625 dimerization interface [polypeptide binding]; other site 644042006626 putative ATP binding site [chemical binding]; other site 644042006627 amidophosphoribosyltransferase; Provisional; Region: PRK07272 644042006628 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 644042006629 active site 644042006630 tetramer interface [polypeptide binding]; other site 644042006631 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644042006632 active site 644042006633 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 644042006634 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 644042006635 dimerization interface [polypeptide binding]; other site 644042006636 ATP binding site [chemical binding]; other site 644042006637 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 644042006638 dimerization interface [polypeptide binding]; other site 644042006639 ATP binding site [chemical binding]; other site 644042006640 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 644042006641 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 644042006642 putative active site [active] 644042006643 catalytic triad [active] 644042006644 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 644042006645 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 644042006646 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 644042006647 ATP binding site [chemical binding]; other site 644042006648 active site 644042006649 substrate binding site [chemical binding]; other site 644042006650 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 644042006651 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 644042006652 NAD binding site [chemical binding]; other site 644042006653 ATP-grasp domain; Region: ATP-grasp; pfam02222 644042006654 AIR carboxylase; Region: AIRC; pfam00731 644042006655 Predicted flavoprotein [General function prediction only]; Region: COG0431 644042006656 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 644042006657 PAS domain; Region: PAS_10; pfam13596 644042006658 Predicted flavoprotein [General function prediction only]; Region: COG0431 644042006659 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 644042006660 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 644042006661 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 644042006662 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 644042006663 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 644042006664 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 644042006665 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 644042006666 active site 644042006667 zinc binding site [ion binding]; other site 644042006668 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 644042006669 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 644042006670 active site 644042006671 homotetramer interface [polypeptide binding]; other site 644042006672 homodimer interface [polypeptide binding]; other site 644042006673 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644042006674 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 644042006675 Walker A/P-loop; other site 644042006676 ATP binding site [chemical binding]; other site 644042006677 Q-loop/lid; other site 644042006678 ABC transporter signature motif; other site 644042006679 Walker B; other site 644042006680 D-loop; other site 644042006681 H-loop/switch region; other site 644042006682 FtsX-like permease family; Region: FtsX; pfam02687 644042006683 Predicted transcriptional regulators [Transcription]; Region: COG1725 644042006684 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042006685 DNA-binding site [nucleotide binding]; DNA binding site 644042006686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042006687 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 644042006688 Walker A/P-loop; other site 644042006689 ATP binding site [chemical binding]; other site 644042006690 Q-loop/lid; other site 644042006691 ABC transporter signature motif; other site 644042006692 Walker B; other site 644042006693 D-loop; other site 644042006694 H-loop/switch region; other site 644042006695 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644042006696 Ligand Binding Site [chemical binding]; other site 644042006697 Predicted membrane protein [Function unknown]; Region: COG2246 644042006698 GtrA-like protein; Region: GtrA; pfam04138 644042006699 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 644042006700 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644042006701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042006702 homodimer interface [polypeptide binding]; other site 644042006703 catalytic residue [active] 644042006704 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 644042006705 homodimer interface [polypeptide binding]; other site 644042006706 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 644042006707 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 644042006708 active site 644042006709 homodimer interface [polypeptide binding]; other site 644042006710 catalytic site [active] 644042006711 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 644042006712 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 644042006713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042006714 catalytic residue [active] 644042006715 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 644042006716 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042006717 active site 644042006718 motif I; other site 644042006719 motif II; other site 644042006720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 644042006721 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 644042006722 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 644042006723 maltose O-acetyltransferase; Provisional; Region: PRK10092 644042006724 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 644042006725 active site 644042006726 substrate binding site [chemical binding]; other site 644042006727 trimer interface [polypeptide binding]; other site 644042006728 CoA binding site [chemical binding]; other site 644042006729 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 644042006730 dimer interface [polypeptide binding]; other site 644042006731 ADP-ribose binding site [chemical binding]; other site 644042006732 active site 644042006733 nudix motif; other site 644042006734 metal binding site [ion binding]; metal-binding site 644042006735 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 644042006736 nucleotide binding site/active site [active] 644042006737 HIT family signature motif; other site 644042006738 catalytic residue [active] 644042006739 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 644042006740 classical (c) SDRs; Region: SDR_c; cd05233 644042006741 NAD(P) binding site [chemical binding]; other site 644042006742 active site 644042006743 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 644042006744 Uncharacterized conserved protein [Function unknown]; Region: COG3589 644042006745 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 644042006746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 644042006747 Sterol carrier protein domain; Region: SCP2_2; pfam13530 644042006748 H+ Antiporter protein; Region: 2A0121; TIGR00900 644042006749 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 644042006750 HTH domain; Region: HTH_11; pfam08279 644042006751 3H domain; Region: 3H; pfam02829 644042006752 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 644042006753 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 644042006754 active site 644042006755 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042006756 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644042006757 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 644042006758 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 644042006759 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 644042006760 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 644042006761 Walker A/P-loop; other site 644042006762 ATP binding site [chemical binding]; other site 644042006763 Q-loop/lid; other site 644042006764 ABC transporter signature motif; other site 644042006765 Walker B; other site 644042006766 D-loop; other site 644042006767 H-loop/switch region; other site 644042006768 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 644042006769 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 644042006770 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644042006771 catalytic residue [active] 644042006772 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 644042006773 beta-galactosidase; Region: BGL; TIGR03356 644042006774 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 644042006775 beta-galactosidase; Region: BGL; TIGR03356 644042006776 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 644042006777 active site 644042006778 methionine cluster; other site 644042006779 phosphorylation site [posttranslational modification] 644042006780 metal binding site [ion binding]; metal-binding site 644042006781 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 644042006782 active site 644042006783 P-loop; other site 644042006784 phosphorylation site [posttranslational modification] 644042006785 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 644042006786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042006787 DNA-binding site [nucleotide binding]; DNA binding site 644042006788 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 644042006789 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 644042006790 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 644042006791 active site 644042006792 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644042006793 catalytic core [active] 644042006794 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644042006795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042006796 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 644042006797 active site 644042006798 motif I; other site 644042006799 motif II; other site 644042006800 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 644042006801 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 644042006802 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 644042006803 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 644042006804 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 644042006805 EamA-like transporter family; Region: EamA; cl17759 644042006806 EamA-like transporter family; Region: EamA; pfam00892 644042006807 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 644042006808 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 644042006809 putative ligand binding site [chemical binding]; other site 644042006810 NAD binding site [chemical binding]; other site 644042006811 catalytic site [active] 644042006812 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 644042006813 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 644042006814 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 644042006815 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 644042006816 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 644042006817 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 644042006818 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 644042006819 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 644042006820 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 644042006821 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 644042006822 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 644042006823 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 644042006824 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 644042006825 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 644042006826 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 644042006827 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 644042006828 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 644042006829 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 644042006830 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 644042006831 active site 644042006832 catalytic residue [active] 644042006833 dimer interface [polypeptide binding]; other site 644042006834 inner membrane transporter YjeM; Provisional; Region: PRK15238 644042006835 Transcriptional regulators [Transcription]; Region: MarR; COG1846 644042006836 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 644042006837 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644042006838 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644042006839 active site 644042006840 catalytic tetrad [active] 644042006841 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644042006842 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644042006843 active site 644042006844 catalytic tetrad [active] 644042006845 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042006846 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042006847 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 644042006848 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 644042006849 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 644042006850 active site 644042006851 HIGH motif; other site 644042006852 dimer interface [polypeptide binding]; other site 644042006853 KMSKS motif; other site 644042006854 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644042006855 RNA binding surface [nucleotide binding]; other site 644042006856 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 644042006857 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 644042006858 active site 644042006859 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 644042006860 putative active site [active] 644042006861 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 644042006862 Protein of unknown function (DUF554); Region: DUF554; pfam04474 644042006863 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 644042006864 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 644042006865 DNA binding residues [nucleotide binding] 644042006866 drug binding residues [chemical binding]; other site 644042006867 dimer interface [polypeptide binding]; other site 644042006868 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 644042006869 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 644042006870 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 644042006871 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 644042006872 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 644042006873 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644042006874 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 644042006875 Walker A/P-loop; other site 644042006876 ATP binding site [chemical binding]; other site 644042006877 Q-loop/lid; other site 644042006878 ABC transporter signature motif; other site 644042006879 Walker B; other site 644042006880 D-loop; other site 644042006881 H-loop/switch region; other site 644042006882 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 644042006883 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 644042006884 active site 644042006885 RibD C-terminal domain; Region: RibD_C; cl17279 644042006886 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 644042006887 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 644042006888 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 644042006889 Predicted permeases [General function prediction only]; Region: COG0679 644042006890 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 644042006891 Aspartase; Region: Aspartase; cd01357 644042006892 active sites [active] 644042006893 tetramer interface [polypeptide binding]; other site 644042006894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042006895 putative substrate translocation pore; other site 644042006896 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 644042006897 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 644042006898 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 644042006899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042006900 putative substrate translocation pore; other site 644042006901 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042006902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 644042006903 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 644042006904 Predicted membrane protein [Function unknown]; Region: COG2855 644042006905 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042006906 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042006907 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644042006908 dimerization interface [polypeptide binding]; other site 644042006909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 644042006910 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 644042006911 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 644042006912 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 644042006913 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 644042006914 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644042006915 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 644042006916 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 644042006917 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644042006918 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644042006919 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 644042006920 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644042006921 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 644042006922 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 644042006923 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 644042006924 DNA binding site [nucleotide binding] 644042006925 active site 644042006926 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 644042006927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042006928 Walker A/P-loop; other site 644042006929 ATP binding site [chemical binding]; other site 644042006930 Q-loop/lid; other site 644042006931 ABC transporter signature motif; other site 644042006932 Walker B; other site 644042006933 D-loop; other site 644042006934 H-loop/switch region; other site 644042006935 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 644042006936 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 644042006937 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 644042006938 classical (c) SDRs; Region: SDR_c; cd05233 644042006939 NAD(P) binding site [chemical binding]; other site 644042006940 active site 644042006941 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 644042006942 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 644042006943 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 644042006944 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 644042006945 DNA binding residues [nucleotide binding] 644042006946 putative dimer interface [polypeptide binding]; other site 644042006947 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 644042006948 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 644042006949 metal binding site [ion binding]; metal-binding site 644042006950 dimer interface [polypeptide binding]; other site 644042006951 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 644042006952 FtsX-like permease family; Region: FtsX; pfam02687 644042006953 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 644042006954 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 644042006955 FtsX-like permease family; Region: FtsX; pfam02687 644042006956 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644042006957 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 644042006958 Walker A/P-loop; other site 644042006959 ATP binding site [chemical binding]; other site 644042006960 Q-loop/lid; other site 644042006961 ABC transporter signature motif; other site 644042006962 Walker B; other site 644042006963 D-loop; other site 644042006964 H-loop/switch region; other site 644042006965 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 644042006966 endonuclease III; Region: ENDO3c; smart00478 644042006967 minor groove reading motif; other site 644042006968 helix-hairpin-helix signature motif; other site 644042006969 substrate binding pocket [chemical binding]; other site 644042006970 active site 644042006971 maltose O-acetyltransferase; Provisional; Region: PRK10092 644042006972 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 644042006973 active site 644042006974 substrate binding site [chemical binding]; other site 644042006975 trimer interface [polypeptide binding]; other site 644042006976 CoA binding site [chemical binding]; other site 644042006977 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 644042006978 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 644042006979 Catalytic site [active] 644042006980 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 644042006981 PYR/PP interface [polypeptide binding]; other site 644042006982 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 644042006983 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 644042006984 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 644042006985 Catalytic site [active] 644042006986 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 644042006987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644042006988 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 644042006989 Coenzyme A binding pocket [chemical binding]; other site 644042006990 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644042006991 catalytic core [active] 644042006992 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042006993 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042006994 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 644042006995 dimerization interface [polypeptide binding]; other site 644042006996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644042006997 NAD(P) binding site [chemical binding]; other site 644042006998 NADH(P)-binding; Region: NAD_binding_10; pfam13460 644042006999 active site 644042007000 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 644042007001 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 644042007002 catalytic Zn binding site [ion binding]; other site 644042007003 NAD(P) binding site [chemical binding]; other site 644042007004 structural Zn binding site [ion binding]; other site 644042007005 short chain dehydrogenase; Provisional; Region: PRK06940 644042007006 classical (c) SDRs; Region: SDR_c; cd05233 644042007007 NAD(P) binding site [chemical binding]; other site 644042007008 active site 644042007009 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 644042007010 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644042007011 Ligand Binding Site [chemical binding]; other site 644042007012 maltose O-acetyltransferase; Provisional; Region: PRK10092 644042007013 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 644042007014 active site 644042007015 substrate binding site [chemical binding]; other site 644042007016 trimer interface [polypeptide binding]; other site 644042007017 CoA binding site [chemical binding]; other site 644042007018 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 644042007019 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042007020 motif II; other site 644042007021 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 644042007022 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 644042007023 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 644042007024 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644042007025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042007026 homodimer interface [polypeptide binding]; other site 644042007027 catalytic residue [active] 644042007028 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 644042007029 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644042007030 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644042007031 active site 644042007032 catalytic tetrad [active] 644042007033 potential frameshift: common BLAST hit: gi|28379353|ref|NP_786245.1| ABC transporter, ATP-binding and permease protein 644042007034 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 644042007035 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644042007036 Walker A/P-loop; other site 644042007037 ATP binding site [chemical binding]; other site 644042007038 Q-loop/lid; other site 644042007039 ABC transporter signature motif; other site 644042007040 Walker B; other site 644042007041 D-loop; other site 644042007042 H-loop/switch region; other site 644042007043 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644042007044 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644042007045 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644042007046 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 644042007047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042007048 Walker A/P-loop; other site 644042007049 ATP binding site [chemical binding]; other site 644042007050 Q-loop/lid; other site 644042007051 ABC transporter signature motif; other site 644042007052 Walker B; other site 644042007053 D-loop; other site 644042007054 H-loop/switch region; other site 644042007055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042007056 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042007057 putative substrate translocation pore; other site 644042007058 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 644042007059 Predicted membrane protein [Function unknown]; Region: COG1511 644042007060 Predicted membrane protein [Function unknown]; Region: COG1511 644042007061 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 644042007062 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042007063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644042007064 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644042007065 dimerization interface [polypeptide binding]; other site 644042007066 putative DNA binding site [nucleotide binding]; other site 644042007067 putative Zn2+ binding site [ion binding]; other site 644042007068 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 644042007069 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 644042007070 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 644042007071 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 644042007072 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 644042007073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 644042007074 serine/threonine protein kinase; Provisional; Region: PRK14879 644042007075 CAAX protease self-immunity; Region: Abi; pfam02517 644042007076 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 644042007077 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644042007078 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644042007079 ABC transporter; Region: ABC_tran_2; pfam12848 644042007080 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644042007081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042007082 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 644042007083 active site 644042007084 motif I; other site 644042007085 motif II; other site 644042007086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042007087 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 644042007088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042007089 Walker A/P-loop; other site 644042007090 ATP binding site [chemical binding]; other site 644042007091 Q-loop/lid; other site 644042007092 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 644042007093 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 644042007094 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042007095 ABC transporter signature motif; other site 644042007096 Walker B; other site 644042007097 D-loop; other site 644042007098 H-loop/switch region; other site 644042007099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042007100 Walker A/P-loop; other site 644042007101 ATP binding site [chemical binding]; other site 644042007102 Q-loop/lid; other site 644042007103 ABC transporter signature motif; other site 644042007104 Walker B; other site 644042007105 D-loop; other site 644042007106 H-loop/switch region; other site 644042007107 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644042007108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042007109 non-specific DNA binding site [nucleotide binding]; other site 644042007110 salt bridge; other site 644042007111 sequence-specific DNA binding site [nucleotide binding]; other site 644042007112 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 644042007113 TAP-like protein; Region: Abhydrolase_4; pfam08386 644042007114 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 644042007115 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 644042007116 Uncharacterized conserved protein [Function unknown]; Region: COG3379 644042007117 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 644042007118 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 644042007119 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 644042007120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042007121 DNA-binding site [nucleotide binding]; DNA binding site 644042007122 UTRA domain; Region: UTRA; pfam07702 644042007123 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 644042007124 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 644042007125 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 644042007126 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 644042007127 metal binding site [ion binding]; metal-binding site 644042007128 active site 644042007129 I-site; other site 644042007130 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 644042007131 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 644042007132 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644042007133 FeS/SAM binding site; other site 644042007134 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 644042007135 Class III ribonucleotide reductase; Region: RNR_III; cd01675 644042007136 effector binding site; other site 644042007137 active site 644042007138 Zn binding site [ion binding]; other site 644042007139 glycine loop; other site 644042007140 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 644042007141 active site 644042007142 catalytic residues [active] 644042007143 metal binding site [ion binding]; metal-binding site 644042007144 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 644042007145 ApbE family; Region: ApbE; pfam02424 644042007146 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 644042007147 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 644042007148 FMN binding site [chemical binding]; other site 644042007149 active site 644042007150 catalytic residues [active] 644042007151 substrate binding site [chemical binding]; other site 644042007152 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042007153 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042007154 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 644042007155 dimerization interface [polypeptide binding]; other site 644042007156 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 644042007157 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 644042007158 transmembrane helices; other site 644042007159 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 644042007160 Predicted membrane protein [Function unknown]; Region: COG4640 644042007161 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 644042007162 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 644042007163 Double zinc ribbon; Region: DZR; pfam12773 644042007164 Enterocin A Immunity; Region: EntA_Immun; pfam08951 644042007165 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 644042007166 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 644042007167 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 644042007168 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 644042007169 Collagen binding domain; Region: Collagen_bind; pfam05737 644042007170 EamA-like transporter family; Region: EamA; pfam00892 644042007171 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 644042007172 EamA-like transporter family; Region: EamA; pfam00892 644042007173 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 644042007174 catalytic triad [active] 644042007175 catalytic triad [active] 644042007176 oxyanion hole [active] 644042007177 Amidohydrolase; Region: Amidohydro_2; pfam04909 644042007178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042007179 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 644042007180 Predicted transcriptional regulators [Transcription]; Region: COG1733 644042007181 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644042007182 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 644042007183 nucleotide binding site [chemical binding]; other site 644042007184 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644042007185 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644042007186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042007187 Walker A/P-loop; other site 644042007188 ATP binding site [chemical binding]; other site 644042007189 Q-loop/lid; other site 644042007190 ABC transporter signature motif; other site 644042007191 Walker B; other site 644042007192 D-loop; other site 644042007193 H-loop/switch region; other site 644042007194 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 644042007195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644042007196 putative Zn2+ binding site [ion binding]; other site 644042007197 putative DNA binding site [nucleotide binding]; other site 644042007198 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 644042007199 dimer interface [polypeptide binding]; other site 644042007200 FMN binding site [chemical binding]; other site 644042007201 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 644042007202 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644042007203 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644042007204 active site turn [active] 644042007205 phosphorylation site [posttranslational modification] 644042007206 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 644042007207 HPr interaction site; other site 644042007208 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644042007209 active site 644042007210 phosphorylation site [posttranslational modification] 644042007211 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 644042007212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042007213 Walker A/P-loop; other site 644042007214 ATP binding site [chemical binding]; other site 644042007215 Q-loop/lid; other site 644042007216 ABC transporter signature motif; other site 644042007217 Walker B; other site 644042007218 D-loop; other site 644042007219 H-loop/switch region; other site 644042007220 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 644042007221 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 644042007222 TM-ABC transporter signature motif; other site 644042007223 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 644042007224 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 644042007225 zinc binding site [ion binding]; other site 644042007226 putative ligand binding site [chemical binding]; other site 644042007227 WxL domain surface cell wall-binding; Region: WxL; pfam13731 644042007228 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 644042007229 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 644042007230 WxL domain surface cell wall-binding; Region: WxL; pfam13731 644042007231 FOG: CBS domain [General function prediction only]; Region: COG0517 644042007232 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 644042007233 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 644042007234 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 644042007235 Walker A/P-loop; other site 644042007236 ATP binding site [chemical binding]; other site 644042007237 Q-loop/lid; other site 644042007238 ABC transporter signature motif; other site 644042007239 Walker B; other site 644042007240 D-loop; other site 644042007241 H-loop/switch region; other site 644042007242 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 644042007243 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 644042007244 Walker A/P-loop; other site 644042007245 ATP binding site [chemical binding]; other site 644042007246 Q-loop/lid; other site 644042007247 ABC transporter signature motif; other site 644042007248 Walker B; other site 644042007249 D-loop; other site 644042007250 H-loop/switch region; other site 644042007251 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 644042007252 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 644042007253 TM-ABC transporter signature motif; other site 644042007254 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 644042007255 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 644042007256 TM-ABC transporter signature motif; other site 644042007257 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 644042007258 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 644042007259 putative ligand binding site [chemical binding]; other site 644042007260 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 644042007261 active site 644042007262 Predicted membrane protein [Function unknown]; Region: COG2246 644042007263 GtrA-like protein; Region: GtrA; pfam04138 644042007264 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644042007265 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042007266 non-specific DNA binding site [nucleotide binding]; other site 644042007267 salt bridge; other site 644042007268 sequence-specific DNA binding site [nucleotide binding]; other site 644042007269 manganese transport protein MntH; Reviewed; Region: PRK00701 644042007270 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 644042007271 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644042007272 Ligand Binding Site [chemical binding]; other site 644042007273 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 644042007274 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644042007275 dimerization interface [polypeptide binding]; other site 644042007276 putative DNA binding site [nucleotide binding]; other site 644042007277 putative Zn2+ binding site [ion binding]; other site 644042007278 Cadmium resistance transporter; Region: Cad; pfam03596 644042007279 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644042007280 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 644042007281 Walker A/P-loop; other site 644042007282 ATP binding site [chemical binding]; other site 644042007283 Q-loop/lid; other site 644042007284 ABC transporter signature motif; other site 644042007285 Walker B; other site 644042007286 D-loop; other site 644042007287 H-loop/switch region; other site 644042007288 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 644042007289 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 644042007290 FtsX-like permease family; Region: FtsX; pfam02687 644042007291 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 644042007292 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 644042007293 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 644042007294 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 644042007295 active site 644042007296 metal binding site [ion binding]; metal-binding site 644042007297 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644042007298 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042007299 non-specific DNA binding site [nucleotide binding]; other site 644042007300 salt bridge; other site 644042007301 sequence-specific DNA binding site [nucleotide binding]; other site 644042007302 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 644042007303 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644042007304 HPr interaction site; other site 644042007305 active site 644042007306 phosphorylation site [posttranslational modification] 644042007307 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 644042007308 active site 644042007309 P-loop; other site 644042007310 phosphorylation site [posttranslational modification] 644042007311 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 644042007312 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 644042007313 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 644042007314 beta-galactosidase; Region: BGL; TIGR03356 644042007315 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 644042007316 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 644042007317 NADP binding site [chemical binding]; other site 644042007318 putative substrate binding site [chemical binding]; other site 644042007319 active site 644042007320 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 644042007321 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 644042007322 DNA binding residues [nucleotide binding] 644042007323 putative dimer interface [polypeptide binding]; other site 644042007324 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644042007325 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 644042007326 catalytic residue [active] 644042007327 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644042007328 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 644042007329 SdpI/YhfL protein family; Region: SdpI; pfam13630 644042007330 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 644042007331 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 644042007332 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 644042007333 metal binding site [ion binding]; metal-binding site 644042007334 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 644042007335 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 644042007336 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 644042007337 metal binding site [ion binding]; metal-binding site 644042007338 active site 644042007339 I-site; other site 644042007340 DNA polymerase IV; Reviewed; Region: PRK03103 644042007341 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 644042007342 active site 644042007343 DNA binding site [nucleotide binding] 644042007344 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 644042007345 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644042007346 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644042007347 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 644042007348 Walker A/P-loop; other site 644042007349 ATP binding site [chemical binding]; other site 644042007350 Q-loop/lid; other site 644042007351 ABC transporter signature motif; other site 644042007352 Walker B; other site 644042007353 D-loop; other site 644042007354 H-loop/switch region; other site 644042007355 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644042007356 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644042007357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042007358 Walker A/P-loop; other site 644042007359 ATP binding site [chemical binding]; other site 644042007360 Q-loop/lid; other site 644042007361 ABC transporter signature motif; other site 644042007362 Walker B; other site 644042007363 D-loop; other site 644042007364 H-loop/switch region; other site 644042007365 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 644042007366 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 644042007367 metal binding site [ion binding]; metal-binding site 644042007368 dimer interface [polypeptide binding]; other site 644042007369 oxidoreductase; Provisional; Region: PRK06128 644042007370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644042007371 NAD(P) binding site [chemical binding]; other site 644042007372 active site 644042007373 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 644042007374 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644042007375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042007376 non-specific DNA binding site [nucleotide binding]; other site 644042007377 salt bridge; other site 644042007378 sequence-specific DNA binding site [nucleotide binding]; other site 644042007379 inner membrane transporter YjeM; Provisional; Region: PRK15238 644042007380 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 644042007381 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 644042007382 dimer interface [polypeptide binding]; other site 644042007383 active site 644042007384 metal binding site [ion binding]; metal-binding site 644042007385 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 644042007386 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 644042007387 catalytic Zn binding site [ion binding]; other site 644042007388 NAD binding site [chemical binding]; other site 644042007389 structural Zn binding site [ion binding]; other site 644042007390 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 644042007391 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644042007392 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 644042007393 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 644042007394 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 644042007395 MucBP domain; Region: MucBP; pfam06458 644042007396 Helix-turn-helix domain; Region: HTH_18; pfam12833 644042007397 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 644042007398 TfoX C-terminal domain; Region: TfoX_C; pfam04994 644042007399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 644042007400 ATP binding site [chemical binding]; other site 644042007401 Mg2+ binding site [ion binding]; other site 644042007402 G-X-G motif; other site 644042007403 WxL domain surface cell wall-binding; Region: WxL; pfam13731 644042007404 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 644042007405 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 644042007406 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 644042007407 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 644042007408 NAD(P) binding site [chemical binding]; other site 644042007409 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 644042007410 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 644042007411 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 644042007412 WxL domain surface cell wall-binding; Region: WxL; pfam13731 644042007413 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 644042007414 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 644042007415 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 644042007416 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 644042007417 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 644042007418 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 644042007419 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 644042007420 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 644042007421 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 644042007422 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 644042007423 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 644042007424 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042007425 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 644042007426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042007427 motif II; other site 644042007428 Predicted transcriptional regulators [Transcription]; Region: COG1695 644042007429 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 644042007430 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 644042007431 Predicted transcriptional regulators [Transcription]; Region: COG1733 644042007432 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 644042007433 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 644042007434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042007435 putative substrate translocation pore; other site 644042007436 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 644042007437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 644042007438 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 644042007439 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 644042007440 active site 644042007441 dimer interface [polypeptide binding]; other site 644042007442 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 644042007443 Ligand Binding Site [chemical binding]; other site 644042007444 Molecular Tunnel; other site 644042007445 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 644042007446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644042007447 active site 644042007448 phosphorylation site [posttranslational modification] 644042007449 intermolecular recognition site; other site 644042007450 dimerization interface [polypeptide binding]; other site 644042007451 LytTr DNA-binding domain; Region: LytTR; pfam04397 644042007452 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 644042007453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042007454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644042007455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644042007456 NADH(P)-binding; Region: NAD_binding_10; pfam13460 644042007457 NAD(P) binding site [chemical binding]; other site 644042007458 active site 644042007459 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 644042007460 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 644042007461 NAD(P) binding site [chemical binding]; other site 644042007462 catalytic residues [active] 644042007463 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 644042007464 active site 644042007465 Bacterial SH3 domain; Region: SH3_5; pfam08460 644042007466 Bacterial SH3 domain; Region: SH3_5; pfam08460 644042007467 Bacterial SH3 domain; Region: SH3_5; pfam08460 644042007468 Bacterial SH3 domain; Region: SH3_5; pfam08460 644042007469 Bacterial SH3 domain; Region: SH3_5; pfam08460 644042007470 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 644042007471 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 644042007472 Predicted transcriptional regulators [Transcription]; Region: COG1733 644042007473 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 644042007474 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 644042007475 classical (c) SDRs; Region: SDR_c; cd05233 644042007476 NAD(P) binding site [chemical binding]; other site 644042007477 active site 644042007478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042007479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644042007480 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 644042007481 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 644042007482 NADP binding site [chemical binding]; other site 644042007483 putative substrate binding site [chemical binding]; other site 644042007484 active site 644042007485 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 644042007486 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644042007487 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644042007488 active site 644042007489 catalytic tetrad [active] 644042007490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042007491 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042007492 putative substrate translocation pore; other site 644042007493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042007494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042007495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644042007496 potential frameshift: common BLAST hit: gi|28379516|ref|NP_786408.1| ferrichrome ABC transporter, substrate binding lipo protein 644042007497 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 644042007498 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 644042007499 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 644042007500 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 644042007501 intersubunit interface [polypeptide binding]; other site 644042007502 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 644042007503 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 644042007504 Walker A/P-loop; other site 644042007505 ATP binding site [chemical binding]; other site 644042007506 Q-loop/lid; other site 644042007507 ABC transporter signature motif; other site 644042007508 Walker B; other site 644042007509 D-loop; other site 644042007510 H-loop/switch region; other site 644042007511 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 644042007512 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644042007513 ABC-ATPase subunit interface; other site 644042007514 dimer interface [polypeptide binding]; other site 644042007515 putative PBP binding regions; other site 644042007516 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 644042007517 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644042007518 ABC-ATPase subunit interface; other site 644042007519 dimer interface [polypeptide binding]; other site 644042007520 putative PBP binding regions; other site 644042007521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644042007522 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 644042007523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644042007524 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 644042007525 NAD(P) binding site [chemical binding]; other site 644042007526 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 644042007527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644042007528 NAD(P) binding site [chemical binding]; other site 644042007529 active site 644042007530 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 644042007531 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 644042007532 putative trimer interface [polypeptide binding]; other site 644042007533 putative CoA binding site [chemical binding]; other site 644042007534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644042007535 NAD(P) binding site [chemical binding]; other site 644042007536 active site 644042007537 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 644042007538 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 644042007539 DNA binding residues [nucleotide binding] 644042007540 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 644042007541 MucBP domain; Region: MucBP; pfam06458 644042007542 MucBP domain; Region: MucBP; pfam06458 644042007543 MucBP domain; Region: MucBP; pfam06458 644042007544 MucBP domain; Region: MucBP; pfam06458 644042007545 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 644042007546 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 644042007547 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 644042007548 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 644042007549 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 644042007550 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 644042007551 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 644042007552 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 644042007553 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 644042007554 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 644042007555 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 644042007556 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 644042007557 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042007558 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042007559 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644042007560 GTP-binding protein LepA; Provisional; Region: PRK05433 644042007561 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 644042007562 G1 box; other site 644042007563 putative GEF interaction site [polypeptide binding]; other site 644042007564 GTP/Mg2+ binding site [chemical binding]; other site 644042007565 Switch I region; other site 644042007566 G2 box; other site 644042007567 G3 box; other site 644042007568 Switch II region; other site 644042007569 G4 box; other site 644042007570 G5 box; other site 644042007571 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 644042007572 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 644042007573 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 644042007574 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 644042007575 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 644042007576 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 644042007577 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 644042007578 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 644042007579 putative NADH binding site [chemical binding]; other site 644042007580 putative active site [active] 644042007581 nudix motif; other site 644042007582 putative metal binding site [ion binding]; other site 644042007583 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 644042007584 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042007585 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042007586 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042007587 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042007588 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 644042007589 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 644042007590 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 644042007591 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 644042007592 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 644042007593 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 644042007594 dimerization interface [polypeptide binding]; other site 644042007595 DPS ferroxidase diiron center [ion binding]; other site 644042007596 ion pore; other site 644042007597 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 644042007598 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042007599 DNA-binding site [nucleotide binding]; DNA binding site 644042007600 UTRA domain; Region: UTRA; pfam07702 644042007601 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 644042007602 beta-galactosidase; Region: BGL; TIGR03356 644042007603 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 644042007604 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 644042007605 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 644042007606 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 644042007607 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 644042007608 DNA binding residues [nucleotide binding] 644042007609 putative dimer interface [polypeptide binding]; other site 644042007610 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 644042007611 Double zinc ribbon; Region: DZR; pfam12773 644042007612 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 644042007613 Protein of unknown function (DUF805); Region: DUF805; pfam05656 644042007614 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 644042007615 Protein of unknown function (DUF3781); Region: DUF3781; pfam12636 644042007616 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 644042007617 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 644042007618 conserved cys residue [active] 644042007619 Predicted transcriptional regulators [Transcription]; Region: COG1733 644042007620 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644042007621 dimerization interface [polypeptide binding]; other site 644042007622 putative DNA binding site [nucleotide binding]; other site 644042007623 putative Zn2+ binding site [ion binding]; other site 644042007624 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 644042007625 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 644042007626 putative NAD(P) binding site [chemical binding]; other site 644042007627 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 644042007628 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 644042007629 Bacterial SH3 domain; Region: SH3_5; pfam08460 644042007630 Bacterial SH3 domain; Region: SH3_5; pfam08460 644042007631 Bacterial SH3 domain; Region: SH3_5; pfam08460 644042007632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 644042007633 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 644042007634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644042007635 ATP binding site [chemical binding]; other site 644042007636 Mg2+ binding site [ion binding]; other site 644042007637 G-X-G motif; other site 644042007638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042007639 ABC transporter signature motif; other site 644042007640 Walker B; other site 644042007641 D-loop; other site 644042007642 H-loop/switch region; other site 644042007643 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 644042007644 AAA domain; Region: AAA_23; pfam13476 644042007645 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042007646 Walker A/P-loop; other site 644042007647 ATP binding site [chemical binding]; other site 644042007648 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 644042007649 Double zinc ribbon; Region: DZR; pfam12773 644042007650 Mor transcription activator family; Region: Mor; cl02360 644042007651 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 644042007652 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 644042007653 Int/Topo IB signature motif; other site 644042007654 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 644042007655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 644042007656 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 644042007657 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 644042007658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644042007659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 644042007660 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644042007661 catalytic core [active] 644042007662 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644042007663 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 644042007664 Domain of unknown function DUF20; Region: UPF0118; pfam01594 644042007665 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644042007666 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 644042007667 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 644042007668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644042007669 S-adenosylmethionine binding site [chemical binding]; other site 644042007670 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 644042007671 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 644042007672 substrate binding site [chemical binding]; other site 644042007673 activation loop (A-loop); other site 644042007674 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 644042007675 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 644042007676 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 644042007677 AzlC protein; Region: AzlC; pfam03591 644042007678 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 644042007679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644042007680 Coenzyme A binding pocket [chemical binding]; other site 644042007681 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 644042007682 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 644042007683 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 644042007684 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 644042007685 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644042007686 dimer interface [polypeptide binding]; other site 644042007687 phosphorylation site [posttranslational modification] 644042007688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644042007689 ATP binding site [chemical binding]; other site 644042007690 Mg2+ binding site [ion binding]; other site 644042007691 G-X-G motif; other site 644042007692 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644042007693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644042007694 active site 644042007695 phosphorylation site [posttranslational modification] 644042007696 intermolecular recognition site; other site 644042007697 dimerization interface [polypeptide binding]; other site 644042007698 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644042007699 DNA binding site [nucleotide binding] 644042007700 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 644042007701 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 644042007702 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 644042007703 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 644042007704 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 644042007705 active site 644042007706 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 644042007707 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 644042007708 GTP-binding protein YchF; Reviewed; Region: PRK09601 644042007709 YchF GTPase; Region: YchF; cd01900 644042007710 G1 box; other site 644042007711 GTP/Mg2+ binding site [chemical binding]; other site 644042007712 Switch I region; other site 644042007713 G2 box; other site 644042007714 Switch II region; other site 644042007715 G3 box; other site 644042007716 G4 box; other site 644042007717 G5 box; other site 644042007718 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 644042007719 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 644042007720 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 644042007721 ParB-like nuclease domain; Region: ParB; smart00470 644042007722 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 644042007723 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 644042007724 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 644042007725 P-loop; other site 644042007726 Magnesium ion binding site [ion binding]; other site 644042007727 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 644042007728 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 644042007729 ParB-like nuclease domain; Region: ParBc; pfam02195 644042007730 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 644042007731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644042007732 S-adenosylmethionine binding site [chemical binding]; other site 644042007733 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 644042007734 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 644042007735 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 644042007736 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 644042007737 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042007738 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042007739 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 644042007740 dimerization interface [polypeptide binding]; other site 644042007741 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644042007742 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 644042007743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042007744 homodimer interface [polypeptide binding]; other site 644042007745 catalytic residue [active] 644042007746 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 644042007747 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644042007748 substrate binding pocket [chemical binding]; other site 644042007749 membrane-bound complex binding site; other site 644042007750 hinge residues; other site 644042007751 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 644042007752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042007753 dimer interface [polypeptide binding]; other site 644042007754 conserved gate region; other site 644042007755 putative PBP binding loops; other site 644042007756 ABC-ATPase subunit interface; other site 644042007757 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 644042007758 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 644042007759 Walker A/P-loop; other site 644042007760 ATP binding site [chemical binding]; other site 644042007761 Q-loop/lid; other site 644042007762 ABC transporter signature motif; other site 644042007763 Walker B; other site 644042007764 D-loop; other site 644042007765 H-loop/switch region; other site 644042007766 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 644042007767 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644042007768 substrate binding pocket [chemical binding]; other site 644042007769 membrane-bound complex binding site; other site 644042007770 hinge residues; other site 644042007771 Predicted transcriptional regulators [Transcription]; Region: COG1695 644042007772 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 644042007773 Predicted membrane protein [Function unknown]; Region: COG4709 644042007774 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 644042007775 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 644042007776 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 644042007777 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644042007778 active site turn [active] 644042007779 phosphorylation site [posttranslational modification] 644042007780 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644042007781 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 644042007782 HPr interaction site; other site 644042007783 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644042007784 active site 644042007785 phosphorylation site [posttranslational modification] 644042007786 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 644042007787 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 644042007788 Ca binding site [ion binding]; other site 644042007789 active site 644042007790 catalytic site [active] 644042007791 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644042007792 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644042007793 DNA binding site [nucleotide binding] 644042007794 domain linker motif; other site 644042007795 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 644042007796 putative dimerization interface [polypeptide binding]; other site 644042007797 putative ligand binding site [chemical binding]; other site 644042007798 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 644042007799 putative active site [active] 644042007800 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 644042007801 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 644042007802 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 644042007803 Walker A/P-loop; other site 644042007804 ATP binding site [chemical binding]; other site 644042007805 Q-loop/lid; other site 644042007806 ABC transporter signature motif; other site 644042007807 Walker B; other site 644042007808 D-loop; other site 644042007809 H-loop/switch region; other site 644042007810 TRAM domain; Region: TRAM; cl01282 644042007811 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 644042007812 Amidohydrolase; Region: Amidohydro_2; pfam04909 644042007813 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 644042007814 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644042007815 active site turn [active] 644042007816 phosphorylation site [posttranslational modification] 644042007817 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644042007818 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 644042007819 HPr interaction site; other site 644042007820 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644042007821 active site 644042007822 phosphorylation site [posttranslational modification] 644042007823 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 644042007824 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042007825 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042007826 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 644042007827 dimerization interface [polypeptide binding]; other site 644042007828 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 644042007829 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 644042007830 NADP binding site [chemical binding]; other site 644042007831 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 644042007832 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042007833 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644042007834 ROK family; Region: ROK; pfam00480 644042007835 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 644042007836 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 644042007837 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 644042007838 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 644042007839 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 644042007840 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 644042007841 active site 644042007842 P-loop; other site 644042007843 phosphorylation site [posttranslational modification] 644042007844 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 644042007845 active site 644042007846 phosphorylation site [posttranslational modification] 644042007847 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 644042007848 HTH domain; Region: HTH_11; pfam08279 644042007849 PRD domain; Region: PRD; pfam00874 644042007850 PRD domain; Region: PRD; pfam00874 644042007851 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 644042007852 active site 644042007853 P-loop; other site 644042007854 phosphorylation site [posttranslational modification] 644042007855 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 644042007856 active site 644042007857 phosphorylation site [posttranslational modification] 644042007858 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 644042007859 DNA binding residues [nucleotide binding] 644042007860 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 644042007861 putative dimer interface [polypeptide binding]; other site 644042007862 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 644042007863 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 644042007864 NADP binding site [chemical binding]; other site 644042007865 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 644042007866 HPr interaction site; other site 644042007867 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644042007868 active site 644042007869 phosphorylation site [posttranslational modification] 644042007870 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 644042007871 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644042007872 active site turn [active] 644042007873 phosphorylation site [posttranslational modification] 644042007874 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644042007875 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 644042007876 endonuclease III; Region: ENDO3c; smart00478 644042007877 minor groove reading motif; other site 644042007878 helix-hairpin-helix signature motif; other site 644042007879 substrate binding pocket [chemical binding]; other site 644042007880 active site 644042007881 Predicted flavoprotein [General function prediction only]; Region: COG0431 644042007882 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 644042007883 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 644042007884 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 644042007885 metal binding site 2 [ion binding]; metal-binding site 644042007886 putative DNA binding helix; other site 644042007887 metal binding site 1 [ion binding]; metal-binding site 644042007888 dimer interface [polypeptide binding]; other site 644042007889 structural Zn2+ binding site [ion binding]; other site 644042007890 Enterocin A Immunity; Region: EntA_Immun; pfam08951 644042007891 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 644042007892 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 644042007893 active site 644042007894 metal binding site [ion binding]; metal-binding site 644042007895 hexamer interface [polypeptide binding]; other site 644042007896 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 644042007897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644042007898 Coenzyme A binding pocket [chemical binding]; other site 644042007899 LrgA family; Region: LrgA; pfam03788 644042007900 LrgB-like family; Region: LrgB; pfam04172 644042007901 EDD domain protein, DegV family; Region: DegV; TIGR00762 644042007902 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 644042007903 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 644042007904 phytoene desaturase; Region: crtI_fam; TIGR02734 644042007905 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 644042007906 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 644042007907 active site lid residues [active] 644042007908 substrate binding pocket [chemical binding]; other site 644042007909 catalytic residues [active] 644042007910 substrate-Mg2+ binding site; other site 644042007911 aspartate-rich region 1; other site 644042007912 aspartate-rich region 2; other site 644042007913 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 644042007914 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 644042007915 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 644042007916 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 644042007917 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644042007918 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644042007919 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 644042007920 Enterocin A Immunity; Region: EntA_Immun; pfam08951 644042007921 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 644042007922 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 644042007923 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 644042007924 adenylosuccinate lyase; Provisional; Region: PRK07492 644042007925 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 644042007926 tetramer interface [polypeptide binding]; other site 644042007927 active site 644042007928 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 644042007929 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 644042007930 GDP-binding site [chemical binding]; other site 644042007931 ACT binding site; other site 644042007932 IMP binding site; other site 644042007933 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 644042007934 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 644042007935 active site 644042007936 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 644042007937 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 644042007938 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 644042007939 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 644042007940 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 644042007941 putative active site [active] 644042007942 catalytic site [active] 644042007943 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 644042007944 putative active site [active] 644042007945 catalytic site [active] 644042007946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042007947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644042007948 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 644042007949 Predicted membrane protein [Function unknown]; Region: COG1511 644042007950 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 644042007951 amino acid transporter; Region: 2A0306; TIGR00909 644042007952 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 644042007953 K+ potassium transporter; Region: K_trans; pfam02705 644042007954 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 644042007955 Cation efflux family; Region: Cation_efflux; pfam01545 644042007956 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 644042007957 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 644042007958 substrate binding site [chemical binding]; other site 644042007959 THF binding site; other site 644042007960 zinc-binding site [ion binding]; other site 644042007961 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 644042007962 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 644042007963 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 644042007964 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 644042007965 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644042007966 dimerization interface [polypeptide binding]; other site 644042007967 putative DNA binding site [nucleotide binding]; other site 644042007968 putative Zn2+ binding site [ion binding]; other site 644042007969 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 644042007970 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644042007971 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042007972 non-specific DNA binding site [nucleotide binding]; other site 644042007973 salt bridge; other site 644042007974 sequence-specific DNA binding site [nucleotide binding]; other site 644042007975 flagellar motor protein MotB; Validated; Region: motB; PRK09041 644042007976 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 644042007977 dihydropteroate synthase; Region: DHPS; TIGR01496 644042007978 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 644042007979 substrate binding pocket [chemical binding]; other site 644042007980 dimer interface [polypeptide binding]; other site 644042007981 inhibitor binding site; inhibition site 644042007982 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 644042007983 active site 644042007984 dimerization interface [polypeptide binding]; other site 644042007985 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 644042007986 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644042007987 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 644042007988 GTP cyclohydrolase I; Provisional; Region: PLN03044 644042007989 active site 644042007990 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 644042007991 catalytic center binding site [active] 644042007992 ATP binding site [chemical binding]; other site 644042007993 Dihydroneopterin aldolase; Region: FolB; pfam02152 644042007994 active site 644042007995 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 644042007996 Colicin V production protein; Region: Colicin_V; pfam02674 644042007997 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 644042007998 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 644042007999 metal binding site [ion binding]; metal-binding site 644042008000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042008001 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042008002 putative substrate translocation pore; other site 644042008003 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 644042008004 Beta-lactamase; Region: Beta-lactamase; pfam00144 644042008005 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 644042008006 Pyruvate formate lyase 1; Region: PFL1; cd01678 644042008007 coenzyme A binding site [chemical binding]; other site 644042008008 active site 644042008009 catalytic residues [active] 644042008010 glycine loop; other site 644042008011 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 644042008012 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644042008013 FeS/SAM binding site; other site 644042008014 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 644042008015 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644042008016 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644042008017 active site 644042008018 catalytic tetrad [active] 644042008019 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 644042008020 nucleotide binding site/active site [active] 644042008021 HIT family signature motif; other site 644042008022 catalytic residue [active] 644042008023 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 644042008024 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 644042008025 active site 644042008026 catalytic triad [active] 644042008027 oxyanion hole [active] 644042008028 BCCT family transporter; Region: BCCT; pfam02028 644042008029 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 644042008030 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644042008031 Soluble P-type ATPase [General function prediction only]; Region: COG4087 644042008032 Protein of unknown function (DUF419); Region: DUF419; cl15265 644042008033 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 644042008034 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 644042008035 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 644042008036 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 644042008037 active site 644042008038 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 644042008039 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 644042008040 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 644042008041 dimer interface [polypeptide binding]; other site 644042008042 active site 644042008043 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 644042008044 potential frameshift: common BLAST hit: gi|28379687|ref|NP_786579.1| Na(+)/H(+) antiporter 644042008045 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 644042008046 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 644042008047 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 644042008048 Spore germination protein; Region: Spore_permease; cl17796 644042008049 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 644042008050 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 644042008051 tetramer interfaces [polypeptide binding]; other site 644042008052 binuclear metal-binding site [ion binding]; other site 644042008053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644042008054 NmrA-like family; Region: NmrA; pfam05368 644042008055 NAD(P) binding site [chemical binding]; other site 644042008056 active site 644042008057 Transcriptional regulators [Transcription]; Region: MarR; COG1846 644042008058 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 644042008059 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 644042008060 ArsC family; Region: ArsC; pfam03960 644042008061 putative catalytic residues [active] 644042008062 thiol/disulfide switch; other site 644042008063 Uncharacterized conserved protein [Function unknown]; Region: COG3189 644042008064 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 644042008065 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 644042008066 minor groove reading motif; other site 644042008067 helix-hairpin-helix signature motif; other site 644042008068 substrate binding pocket [chemical binding]; other site 644042008069 active site 644042008070 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 644042008071 DNA binding and oxoG recognition site [nucleotide binding] 644042008072 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 644042008073 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 644042008074 putative dimer interface [polypeptide binding]; other site 644042008075 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 644042008076 NADH(P)-binding; Region: NAD_binding_10; pfam13460 644042008077 putative NAD(P) binding site [chemical binding]; other site 644042008078 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 644042008079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644042008080 Coenzyme A binding pocket [chemical binding]; other site 644042008081 EamA-like transporter family; Region: EamA; pfam00892 644042008082 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 644042008083 EamA-like transporter family; Region: EamA; pfam00892 644042008084 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 644042008085 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 644042008086 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 644042008087 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 644042008088 active site 644042008089 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 644042008090 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644042008091 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042008092 motif II; other site 644042008093 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 644042008094 Penicillinase repressor; Region: Pencillinase_R; pfam03965 644042008095 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 644042008096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042008097 putative substrate translocation pore; other site 644042008098 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 644042008099 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 644042008100 Na binding site [ion binding]; other site 644042008101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042008102 putative substrate translocation pore; other site 644042008103 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 644042008104 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 644042008105 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 644042008106 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 644042008107 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 644042008108 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 644042008109 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644042008110 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 644042008111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042008112 active site 644042008113 motif I; other site 644042008114 motif II; other site 644042008115 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 644042008116 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 644042008117 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 644042008118 active site 644042008119 metal binding site [ion binding]; metal-binding site 644042008120 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 644042008121 Membrane transport protein; Region: Mem_trans; cl09117 644042008122 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644042008123 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644042008124 active site 644042008125 catalytic tetrad [active] 644042008126 Uncharacterized conserved protein [Function unknown]; Region: COG2966 644042008127 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 644042008128 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 644042008129 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 644042008130 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 644042008131 putative ADP-ribose binding site [chemical binding]; other site 644042008132 putative active site [active] 644042008133 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644042008134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042008135 Predicted secreted protein [Function unknown]; Region: COG4086 644042008136 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 644042008137 WxL domain surface cell wall-binding; Region: WxL; pfam13731 644042008138 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 644042008139 active site 644042008140 nucleotide-binding site [chemical binding]; other site 644042008141 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 644042008142 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 644042008143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042008144 catalytic residue [active] 644042008145 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644042008146 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 644042008147 NlpC/P60 family; Region: NLPC_P60; pfam00877 644042008148 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 644042008149 SnoaL-like domain; Region: SnoaL_4; cl17707 644042008150 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 644042008151 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 644042008152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042008153 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 644042008154 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 644042008155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644042008156 S-adenosylmethionine binding site [chemical binding]; other site 644042008157 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 644042008158 putative active site [active] 644042008159 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 644042008160 active site 644042008161 catalytic triad [active] 644042008162 oxyanion hole [active] 644042008163 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 644042008164 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644042008165 Soluble P-type ATPase [General function prediction only]; Region: COG4087 644042008166 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 644042008167 amphipathic channel; other site 644042008168 Asn-Pro-Ala signature motifs; other site 644042008169 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 644042008170 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 644042008171 catalytic residues [active] 644042008172 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 644042008173 putative homodimer interface [polypeptide binding]; other site 644042008174 putative homotetramer interface [polypeptide binding]; other site 644042008175 putative metal binding site [ion binding]; other site 644042008176 putative homodimer-homodimer interface [polypeptide binding]; other site 644042008177 putative allosteric switch controlling residues; other site 644042008178 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 644042008179 Ferritin-like domain; Region: Ferritin; pfam00210 644042008180 dimerization interface [polypeptide binding]; other site 644042008181 DPS ferroxidase diiron center [ion binding]; other site 644042008182 ion pore; other site 644042008183 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 644042008184 metal-binding site [ion binding] 644042008185 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 644042008186 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 644042008187 ligand binding site [chemical binding]; other site 644042008188 flexible hinge region; other site 644042008189 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 644042008190 non-specific DNA interactions [nucleotide binding]; other site 644042008191 DNA binding site [nucleotide binding] 644042008192 sequence specific DNA binding site [nucleotide binding]; other site 644042008193 putative cAMP binding site [chemical binding]; other site 644042008194 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 644042008195 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 644042008196 active site 644042008197 Zn binding site [ion binding]; other site 644042008198 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 644042008199 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644042008200 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644042008201 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 644042008202 legume lectins; Region: lectin_L-type; cl14058 644042008203 homotetramer interaction site [polypeptide binding]; other site 644042008204 carbohydrate binding site [chemical binding]; other site 644042008205 metal binding site [ion binding]; metal-binding site 644042008206 WxL domain surface cell wall-binding; Region: WxL; pfam13731 644042008207 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 644042008208 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 644042008209 WxL domain surface cell wall-binding; Region: WxL; pfam13731 644042008210 WxL domain surface cell wall-binding; Region: WxL; pfam13731 644042008211 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644042008212 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644042008213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 644042008214 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 644042008215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042008216 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 644042008217 Walker A motif; other site 644042008218 ATP binding site [chemical binding]; other site 644042008219 Walker B motif; other site 644042008220 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 644042008221 amphipathic channel; other site 644042008222 Asn-Pro-Ala signature motifs; other site 644042008223 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 644042008224 ABC1 family; Region: ABC1; cl17513 644042008225 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 644042008226 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 644042008227 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 644042008228 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 644042008229 HPr interaction site; other site 644042008230 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644042008231 active site 644042008232 phosphorylation site [posttranslational modification] 644042008233 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 644042008234 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 644042008235 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 644042008236 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 644042008237 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644042008238 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644042008239 DNA binding site [nucleotide binding] 644042008240 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 644042008241 putative dimerization interface [polypeptide binding]; other site 644042008242 putative ligand binding site [chemical binding]; other site 644042008243 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 644042008244 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042008245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042008246 putative substrate translocation pore; other site 644042008247 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 644042008248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042008249 putative substrate translocation pore; other site 644042008250 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042008251 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 644042008252 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 644042008253 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 644042008254 Fic/DOC family; Region: Fic; cl00960 644042008255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042008256 non-specific DNA binding site [nucleotide binding]; other site 644042008257 salt bridge; other site 644042008258 sequence-specific DNA binding site [nucleotide binding]; other site 644042008259 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 644042008260 FIC domain binding interface [polypeptide binding]; other site 644042008261 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 644042008262 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644042008263 DNA binding site [nucleotide binding] 644042008264 domain linker motif; other site 644042008265 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 644042008266 putative dimerization interface [polypeptide binding]; other site 644042008267 putative ligand binding site [chemical binding]; other site 644042008268 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 644042008269 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 644042008270 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 644042008271 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 644042008272 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 644042008273 NAD binding site [chemical binding]; other site 644042008274 homodimer interface [polypeptide binding]; other site 644042008275 active site 644042008276 substrate binding site [chemical binding]; other site 644042008277 galactokinase; Provisional; Region: PRK05322 644042008278 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 644042008279 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 644042008280 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 644042008281 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 644042008282 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 644042008283 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 644042008284 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 644042008285 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 644042008286 Melibiase; Region: Melibiase; pfam02065 644042008287 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 644042008288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042008289 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 644042008290 HPr interaction site; other site 644042008291 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644042008292 active site 644042008293 phosphorylation site [posttranslational modification] 644042008294 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 644042008295 active site 644042008296 catalytic residues [active] 644042008297 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644042008298 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644042008299 DNA binding site [nucleotide binding] 644042008300 domain linker motif; other site 644042008301 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 644042008302 putative dimerization interface [polypeptide binding]; other site 644042008303 putative ligand binding site [chemical binding]; other site 644042008304 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644042008305 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644042008306 active site 644042008307 catalytic tetrad [active] 644042008308 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 644042008309 FMN-binding domain; Region: FMN_bind; cl01081 644042008310 L-aspartate oxidase; Provisional; Region: PRK06175 644042008311 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 644042008312 Predicted flavoprotein [General function prediction only]; Region: COG0431 644042008313 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 644042008314 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 644042008315 ApbE family; Region: ApbE; pfam02424 644042008316 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 644042008317 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 644042008318 active site 644042008319 catalytic residue [active] 644042008320 dimer interface [polypeptide binding]; other site 644042008321 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 644042008322 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 644042008323 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 644042008324 shikimate binding site; other site 644042008325 NAD(P) binding site [chemical binding]; other site 644042008326 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042008327 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042008328 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 644042008329 putative dimerization interface [polypeptide binding]; other site 644042008330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042008331 putative substrate translocation pore; other site 644042008332 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 644042008333 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 644042008334 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 644042008335 shikimate binding site; other site 644042008336 NAD(P) binding site [chemical binding]; other site 644042008337 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 644042008338 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 644042008339 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 644042008340 shikimate binding site; other site 644042008341 NAD(P) binding site [chemical binding]; other site 644042008342 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 644042008343 classical (c) SDRs; Region: SDR_c; cd05233 644042008344 NAD(P) binding site [chemical binding]; other site 644042008345 active site 644042008346 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 644042008347 Transcriptional regulator [Transcription]; Region: LysR; COG0583 644042008348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 644042008349 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 644042008350 putative dimerization interface [polypeptide binding]; other site 644042008351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042008352 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042008353 putative substrate translocation pore; other site 644042008354 Putative esterase; Region: Esterase; pfam00756 644042008355 S-formylglutathione hydrolase; Region: PLN02442 644042008356 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 644042008357 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042008358 DNA-binding site [nucleotide binding]; DNA binding site 644042008359 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 644042008360 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 644042008361 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 644042008362 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570 644042008363 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 644042008364 putative active site [active] 644042008365 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 644042008366 Uncharacterized conserved protein [Function unknown]; Region: COG3589 644042008367 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 644042008368 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 644042008369 beta-galactosidase; Region: BGL; TIGR03356 644042008370 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 644042008371 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644042008372 active site turn [active] 644042008373 phosphorylation site [posttranslational modification] 644042008374 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644042008375 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 644042008376 HPr interaction site; other site 644042008377 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644042008378 active site 644042008379 phosphorylation site [posttranslational modification] 644042008380 PRD domain; Region: PRD; pfam00874 644042008381 PRD domain; Region: PRD; pfam00874 644042008382 putative frv operon regulatory protein; Provisional; Region: PRK09863 644042008383 HTH domain; Region: HTH_11; pfam08279 644042008384 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 644042008385 active site 644042008386 phosphorylation site [posttranslational modification] 644042008387 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 644042008388 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644042008389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644042008390 homodimer interface [polypeptide binding]; other site 644042008391 catalytic residue [active] 644042008392 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 644042008393 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 644042008394 active site 644042008395 P-loop; other site 644042008396 phosphorylation site [posttranslational modification] 644042008397 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 644042008398 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 644042008399 active site 644042008400 phosphorylation site [posttranslational modification] 644042008401 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 644042008402 HPr interaction site; other site 644042008403 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644042008404 active site 644042008405 phosphorylation site [posttranslational modification] 644042008406 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 644042008407 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 644042008408 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 644042008409 putative active site [active] 644042008410 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644042008411 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 644042008412 active site turn [active] 644042008413 phosphorylation site [posttranslational modification] 644042008414 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644042008415 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 644042008416 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 644042008417 putative active site [active] 644042008418 Uncharacterized conserved protein [Function unknown]; Region: COG3589 644042008419 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 644042008420 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 644042008421 beta-galactosidase; Region: BGL; TIGR03356 644042008422 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 644042008423 beta-galactosidase; Region: BGL; TIGR03356 644042008424 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 644042008425 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644042008426 active site turn [active] 644042008427 phosphorylation site [posttranslational modification] 644042008428 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644042008429 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 644042008430 HPr interaction site; other site 644042008431 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644042008432 active site 644042008433 phosphorylation site [posttranslational modification] 644042008434 transcriptional antiterminator BglG; Provisional; Region: PRK09772 644042008435 CAT RNA binding domain; Region: CAT_RBD; smart01061 644042008436 PRD domain; Region: PRD; pfam00874 644042008437 PRD domain; Region: PRD; pfam00874 644042008438 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 644042008439 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 644042008440 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 644042008441 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 644042008442 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644042008443 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644042008444 DNA binding site [nucleotide binding] 644042008445 domain linker motif; other site 644042008446 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 644042008447 dimerization interface [polypeptide binding]; other site 644042008448 ligand binding site [chemical binding]; other site 644042008449 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042008450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042008451 putative substrate translocation pore; other site 644042008452 putative alpha-glucosidase; Provisional; Region: PRK10658 644042008453 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 644042008454 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 644042008455 trimer interface [polypeptide binding]; other site 644042008456 active site 644042008457 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 644042008458 catalytic site [active] 644042008459 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 644042008460 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 644042008461 active site 644042008462 sugar phosphate phosphatase; Provisional; Region: PRK10513 644042008463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042008464 active site 644042008465 motif I; other site 644042008466 motif II; other site 644042008467 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 644042008468 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 644042008469 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 644042008470 TPP-binding site [chemical binding]; other site 644042008471 dimer interface [polypeptide binding]; other site 644042008472 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 644042008473 PYR/PP interface [polypeptide binding]; other site 644042008474 dimer interface [polypeptide binding]; other site 644042008475 TPP binding site [chemical binding]; other site 644042008476 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 644042008477 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 644042008478 active site 644042008479 intersubunit interactions; other site 644042008480 catalytic residue [active] 644042008481 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 644042008482 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 644042008483 active site 644042008484 P-loop; other site 644042008485 phosphorylation site [posttranslational modification] 644042008486 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 644042008487 active site 644042008488 phosphorylation site [posttranslational modification] 644042008489 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 644042008490 PRD domain; Region: PRD; pfam00874 644042008491 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 644042008492 active site 644042008493 P-loop; other site 644042008494 phosphorylation site [posttranslational modification] 644042008495 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 644042008496 active site 644042008497 phosphorylation site [posttranslational modification] 644042008498 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 644042008499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042008500 motif II; other site 644042008501 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 644042008502 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 644042008503 putative NAD(P) binding site [chemical binding]; other site 644042008504 catalytic Zn binding site [ion binding]; other site 644042008505 structural Zn binding site [ion binding]; other site 644042008506 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 644042008507 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 644042008508 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 644042008509 active site 644042008510 P-loop; other site 644042008511 phosphorylation site [posttranslational modification] 644042008512 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 644042008513 active site 644042008514 phosphorylation site [posttranslational modification] 644042008515 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 644042008516 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 644042008517 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 644042008518 putative phosphoketolase; Provisional; Region: PRK05261 644042008519 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 644042008520 TPP-binding site; other site 644042008521 XFP C-terminal domain; Region: XFP_C; pfam09363 644042008522 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 644042008523 maltose O-acetyltransferase; Provisional; Region: PRK10092 644042008524 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 644042008525 active site 644042008526 substrate binding site [chemical binding]; other site 644042008527 trimer interface [polypeptide binding]; other site 644042008528 CoA binding site [chemical binding]; other site 644042008529 L-arabinose isomerase; Provisional; Region: PRK02929 644042008530 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 644042008531 hexamer (dimer of trimers) interface [polypeptide binding]; other site 644042008532 substrate binding site [chemical binding]; other site 644042008533 trimer interface [polypeptide binding]; other site 644042008534 Mn binding site [ion binding]; other site 644042008535 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 644042008536 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 644042008537 intersubunit interface [polypeptide binding]; other site 644042008538 active site 644042008539 Zn2+ binding site [ion binding]; other site 644042008540 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 644042008541 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 644042008542 putative N- and C-terminal domain interface [polypeptide binding]; other site 644042008543 putative active site [active] 644042008544 MgATP binding site [chemical binding]; other site 644042008545 catalytic site [active] 644042008546 metal binding site [ion binding]; metal-binding site 644042008547 putative carbohydrate binding site [chemical binding]; other site 644042008548 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 644042008549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042008550 putative substrate translocation pore; other site 644042008551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042008552 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042008553 DNA-binding site [nucleotide binding]; DNA binding site 644042008554 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 644042008555 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 644042008556 putative dimerization interface [polypeptide binding]; other site 644042008557 putative ligand binding site [chemical binding]; other site 644042008558 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 644042008559 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 644042008560 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 644042008561 putative active site [active] 644042008562 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 644042008563 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 644042008564 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 644042008565 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 644042008566 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 644042008567 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 644042008568 Na binding site [ion binding]; other site 644042008569 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 644042008570 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 644042008571 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 644042008572 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644042008573 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 644042008574 nucleotide binding site [chemical binding]; other site 644042008575 N-acetylneuraminate lyase; Provisional; Region: PRK04147 644042008576 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 644042008577 inhibitor site; inhibition site 644042008578 active site 644042008579 dimer interface [polypeptide binding]; other site 644042008580 catalytic residue [active] 644042008581 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 644042008582 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 644042008583 putative active site cavity [active] 644042008584 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 644042008585 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644042008586 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644042008587 conserved hypothetical protein; Region: TIGR02328 644042008588 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 644042008589 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 644042008590 Predicted membrane protein [Function unknown]; Region: COG2261 644042008591 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 644042008592 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 644042008593 heme binding pocket [chemical binding]; other site 644042008594 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 644042008595 ArsC family; Region: ArsC; pfam03960 644042008596 putative catalytic residues [active] 644042008597 thiol/disulfide switch; other site 644042008598 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 644042008599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644042008600 active site 644042008601 phosphorylation site [posttranslational modification] 644042008602 intermolecular recognition site; other site 644042008603 dimerization interface [polypeptide binding]; other site 644042008604 LytTr DNA-binding domain; Region: LytTR; pfam04397 644042008605 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 644042008606 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 644042008607 Accessory gene regulator B; Region: AgrB; smart00793 644042008608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042008609 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 644042008610 Walker A motif; other site 644042008611 ATP binding site [chemical binding]; other site 644042008612 Walker B motif; other site 644042008613 arginine finger; other site 644042008614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644042008615 Walker A motif; other site 644042008616 ATP binding site [chemical binding]; other site 644042008617 Walker B motif; other site 644042008618 arginine finger; other site 644042008619 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 644042008620 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 644042008621 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 644042008622 teramer interface [polypeptide binding]; other site 644042008623 active site 644042008624 FMN binding site [chemical binding]; other site 644042008625 catalytic residues [active] 644042008626 pyruvate oxidase; Provisional; Region: PRK08611 644042008627 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 644042008628 PYR/PP interface [polypeptide binding]; other site 644042008629 dimer interface [polypeptide binding]; other site 644042008630 tetramer interface [polypeptide binding]; other site 644042008631 TPP binding site [chemical binding]; other site 644042008632 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 644042008633 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 644042008634 TPP-binding site [chemical binding]; other site 644042008635 Transcriptional regulator; Region: Rrf2; pfam02082 644042008636 Rrf2 family protein; Region: rrf2_super; TIGR00738 644042008637 Transcriptional regulator; Region: Rrf2; cl17282 644042008638 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 644042008639 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 644042008640 PYR/PP interface [polypeptide binding]; other site 644042008641 dimer interface [polypeptide binding]; other site 644042008642 tetramer interface [polypeptide binding]; other site 644042008643 TPP binding site [chemical binding]; other site 644042008644 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 644042008645 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 644042008646 TPP-binding site [chemical binding]; other site 644042008647 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 644042008648 Predicted membrane protein [Function unknown]; Region: COG2364 644042008649 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 644042008650 intersubunit interface [polypeptide binding]; other site 644042008651 active site 644042008652 Zn2+ binding site [ion binding]; other site 644042008653 L-rhamnose isomerase; Provisional; Region: PRK01076 644042008654 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 644042008655 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 644042008656 N- and C-terminal domain interface [polypeptide binding]; other site 644042008657 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 644042008658 active site 644042008659 putative catalytic site [active] 644042008660 metal binding site [ion binding]; metal-binding site 644042008661 ATP binding site [chemical binding]; other site 644042008662 carbohydrate binding site [chemical binding]; other site 644042008663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042008664 putative substrate translocation pore; other site 644042008665 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644042008666 Cupin domain; Region: Cupin_2; pfam07883 644042008667 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 644042008668 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 644042008669 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 644042008670 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 644042008671 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 644042008672 active site 644042008673 phosphorylation site [posttranslational modification] 644042008674 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 644042008675 active site 644042008676 P-loop; other site 644042008677 phosphorylation site [posttranslational modification] 644042008678 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 644042008679 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 644042008680 hypothetical protein; Provisional; Region: PRK06357 644042008681 intersubunit interface [polypeptide binding]; other site 644042008682 active site 644042008683 Zn2+ binding site [ion binding]; other site 644042008684 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 644042008685 HPr interaction site; other site 644042008686 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644042008687 active site 644042008688 phosphorylation site [posttranslational modification] 644042008689 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644042008690 active site turn [active] 644042008691 phosphorylation site [posttranslational modification] 644042008692 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 644042008693 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 644042008694 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 644042008695 putative active site [active] 644042008696 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 644042008697 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644042008698 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644042008699 active site turn [active] 644042008700 phosphorylation site [posttranslational modification] 644042008701 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 644042008702 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 644042008703 NAD binding site [chemical binding]; other site 644042008704 sugar binding site [chemical binding]; other site 644042008705 divalent metal binding site [ion binding]; other site 644042008706 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 644042008707 dimer interface [polypeptide binding]; other site 644042008708 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 644042008709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644042008710 motif II; other site 644042008711 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 644042008712 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644042008713 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644042008714 active site turn [active] 644042008715 phosphorylation site [posttranslational modification] 644042008716 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 644042008717 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 644042008718 NAD binding site [chemical binding]; other site 644042008719 sugar binding site [chemical binding]; other site 644042008720 divalent metal binding site [ion binding]; other site 644042008721 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 644042008722 dimer interface [polypeptide binding]; other site 644042008723 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644042008724 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644042008725 DNA binding site [nucleotide binding] 644042008726 domain linker motif; other site 644042008727 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 644042008728 ligand binding site [chemical binding]; other site 644042008729 dimerization interface [polypeptide binding]; other site 644042008730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644042008731 MFS/sugar transport protein; Region: MFS_2; pfam13347 644042008732 putative substrate translocation pore; other site 644042008733 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 644042008734 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 644042008735 Ca binding site [ion binding]; other site 644042008736 active site 644042008737 catalytic site [active] 644042008738 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 644042008739 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 644042008740 beta-galactosidase; Region: BGL; TIGR03356 644042008741 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644042008742 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 644042008743 nucleotide binding site [chemical binding]; other site 644042008744 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 644042008745 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 644042008746 active site 644042008747 metal binding site [ion binding]; metal-binding site 644042008748 homodimer interface [polypeptide binding]; other site 644042008749 catalytic site [active] 644042008750 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 644042008751 Uncharacterized conserved protein [Function unknown]; Region: COG3538 644042008752 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 644042008753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042008754 DNA-binding site [nucleotide binding]; DNA binding site 644042008755 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644042008756 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 644042008757 ligand binding site [chemical binding]; other site 644042008758 dimerization interface [polypeptide binding]; other site 644042008759 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 644042008760 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 644042008761 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 644042008762 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 644042008763 Walker A/P-loop; other site 644042008764 ATP binding site [chemical binding]; other site 644042008765 Q-loop/lid; other site 644042008766 ABC transporter signature motif; other site 644042008767 Walker B; other site 644042008768 D-loop; other site 644042008769 H-loop/switch region; other site 644042008770 TOBE domain; Region: TOBE_2; pfam08402 644042008771 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644042008772 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 644042008773 Response regulator receiver domain; Region: Response_reg; pfam00072 644042008774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644042008775 active site 644042008776 phosphorylation site [posttranslational modification] 644042008777 intermolecular recognition site; other site 644042008778 dimerization interface [polypeptide binding]; other site 644042008779 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 644042008780 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 644042008781 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 644042008782 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 644042008783 Histidine kinase; Region: His_kinase; pfam06580 644042008784 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 644042008785 ATP binding site [chemical binding]; other site 644042008786 Mg2+ binding site [ion binding]; other site 644042008787 G-X-G motif; other site 644042008788 Protein of unknown function, DUF624; Region: DUF624; cl02369 644042008789 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 644042008790 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 644042008791 Ca binding site [ion binding]; other site 644042008792 active site 644042008793 catalytic site [active] 644042008794 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 644042008795 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 644042008796 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 644042008797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042008798 dimer interface [polypeptide binding]; other site 644042008799 conserved gate region; other site 644042008800 putative PBP binding loops; other site 644042008801 ABC-ATPase subunit interface; other site 644042008802 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 644042008803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644042008804 dimer interface [polypeptide binding]; other site 644042008805 putative PBP binding loops; other site 644042008806 ABC-ATPase subunit interface; other site 644042008807 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 644042008808 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 644042008809 putative active site [active] 644042008810 Cupin domain; Region: Cupin_2; cl17218 644042008811 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 644042008812 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 644042008813 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 644042008814 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644042008815 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644042008816 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644042008817 Walker A/P-loop; other site 644042008818 ATP binding site [chemical binding]; other site 644042008819 Q-loop/lid; other site 644042008820 ABC transporter signature motif; other site 644042008821 Walker B; other site 644042008822 D-loop; other site 644042008823 H-loop/switch region; other site 644042008824 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644042008825 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644042008826 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 644042008827 Walker A/P-loop; other site 644042008828 ATP binding site [chemical binding]; other site 644042008829 Q-loop/lid; other site 644042008830 ABC transporter signature motif; other site 644042008831 Walker B; other site 644042008832 D-loop; other site 644042008833 H-loop/switch region; other site 644042008834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644042008835 DNA-binding site [nucleotide binding]; DNA binding site 644042008836 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644042008837 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 644042008838 ligand binding site [chemical binding]; other site 644042008839 dimerization interface [polypeptide binding]; other site 644042008840 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 644042008841 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 644042008842 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 644042008843 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 644042008844 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 644042008845 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 644042008846 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 644042008847 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 644042008848 HTH domain; Region: HTH_11; pfam08279 644042008849 PRD domain; Region: PRD; pfam00874 644042008850 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 644042008851 active site 644042008852 phosphorylation site [posttranslational modification] 644042008853 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 644042008854 classical (c) SDRs; Region: SDR_c; cd05233 644042008855 NAD(P) binding site [chemical binding]; other site 644042008856 active site 644042008857 Sugar transport protein; Region: Sugar_transport; pfam06800 644042008858 D-ribose pyranase; Provisional; Region: PRK11797 644042008859 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 644042008860 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 644042008861 substrate binding site [chemical binding]; other site 644042008862 dimer interface [polypeptide binding]; other site 644042008863 ATP binding site [chemical binding]; other site 644042008864 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644042008865 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644042008866 DNA binding site [nucleotide binding] 644042008867 domain linker motif; other site 644042008868 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 644042008869 dimerization interface [polypeptide binding]; other site 644042008870 ligand binding site [chemical binding]; other site 644042008871 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 644042008872 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 644042008873 putative catalytic cysteine [active] 644042008874 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 644042008875 putative active site [active] 644042008876 metal binding site [ion binding]; metal-binding site 644042008877 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644042008878 Ligand Binding Site [chemical binding]; other site 644042008879 Predicted transcriptional regulators [Transcription]; Region: COG1695 644042008880 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 644042008881 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 644042008882 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 644042008883 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 644042008884 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 644042008885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644042008886 Coenzyme A binding pocket [chemical binding]; other site 644042008887 EDD domain protein, DegV family; Region: DegV; TIGR00762 644042008888 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 644042008889 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644042008890 non-specific DNA binding site [nucleotide binding]; other site 644042008891 salt bridge; other site 644042008892 sequence-specific DNA binding site [nucleotide binding]; other site 644042008893 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 644042008894 trimer interface [polypeptide binding]; other site 644042008895 active site 644042008896 G bulge; other site 644042008897 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 644042008898 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 644042008899 Catalytic site [active] 644042008900 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 644042008901 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 644042008902 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 644042008903 WxL domain surface cell wall-binding; Region: WxL; pfam13731 644042008904 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 644042008905 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 644042008906 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 644042008907 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 644042008908 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 644042008909 trmE is a tRNA modification GTPase; Region: trmE; cd04164 644042008910 G1 box; other site 644042008911 GTP/Mg2+ binding site [chemical binding]; other site 644042008912 Switch I region; other site 644042008913 G2 box; other site 644042008914 Switch II region; other site 644042008915 G3 box; other site 644042008916 G4 box; other site 644042008917 G5 box; other site 644042008918 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 644042008919 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 644042008920 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 644042008921 G-X-X-G motif; other site 644042008922 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 644042008923 RxxxH motif; other site 644042008924 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 644042008925 Amidohydrolase; Region: Amidohydro_4; pfam13147 644042008926 active site 644042008927 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 644042008928 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 644042008929 peptide binding site [polypeptide binding]; other site 644042008930 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 644042008931 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 644042008932 ribonuclease P; Reviewed; Region: rnpA; PRK00499