-- dump date 20140619_124103 -- class Genbank::misc_feature -- table misc_feature_note -- id note 767468000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 767468000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468000003 Walker A motif; other site 767468000004 ATP binding site [chemical binding]; other site 767468000005 Walker B motif; other site 767468000006 arginine finger; other site 767468000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 767468000008 DnaA box-binding interface [nucleotide binding]; other site 767468000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 767468000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 767468000011 putative DNA binding surface [nucleotide binding]; other site 767468000012 dimer interface [polypeptide binding]; other site 767468000013 beta-clamp/clamp loader binding surface; other site 767468000014 beta-clamp/translesion DNA polymerase binding surface; other site 767468000015 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 767468000016 recombination protein F; Reviewed; Region: recF; PRK00064 767468000017 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 767468000018 Walker A/P-loop; other site 767468000019 ATP binding site [chemical binding]; other site 767468000020 Q-loop/lid; other site 767468000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468000022 ABC transporter signature motif; other site 767468000023 Walker B; other site 767468000024 D-loop; other site 767468000025 H-loop/switch region; other site 767468000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 767468000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767468000028 Mg2+ binding site [ion binding]; other site 767468000029 G-X-G motif; other site 767468000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 767468000031 anchoring element; other site 767468000032 dimer interface [polypeptide binding]; other site 767468000033 ATP binding site [chemical binding]; other site 767468000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 767468000035 active site 767468000036 putative metal-binding site [ion binding]; other site 767468000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 767468000038 DNA gyrase subunit A; Validated; Region: PRK05560 767468000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 767468000040 CAP-like domain; other site 767468000041 active site 767468000042 primary dimer interface [polypeptide binding]; other site 767468000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767468000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767468000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767468000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767468000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767468000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767468000049 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 767468000050 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 767468000051 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 767468000052 dimer interface [polypeptide binding]; other site 767468000053 ssDNA binding site [nucleotide binding]; other site 767468000054 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767468000055 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 767468000056 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 767468000057 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 767468000058 metal binding site [ion binding]; metal-binding site 767468000059 DHH family; Region: DHH; pfam01368 767468000060 DHHA1 domain; Region: DHHA1; pfam02272 767468000061 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 767468000062 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 767468000063 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 767468000064 replicative DNA helicase; Provisional; Region: PRK05748 767468000065 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 767468000066 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 767468000067 Walker A motif; other site 767468000068 ATP binding site [chemical binding]; other site 767468000069 Walker B motif; other site 767468000070 DNA binding loops [nucleotide binding] 767468000071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468000072 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468000073 putative substrate translocation pore; other site 767468000074 gamma-glutamyl kinase; Provisional; Region: PRK05429 767468000075 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 767468000076 nucleotide binding site [chemical binding]; other site 767468000077 homotetrameric interface [polypeptide binding]; other site 767468000078 putative phosphate binding site [ion binding]; other site 767468000079 putative allosteric binding site; other site 767468000080 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 767468000081 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 767468000082 putative catalytic cysteine [active] 767468000083 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767468000084 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767468000085 peptide binding site [polypeptide binding]; other site 767468000086 glycogen branching enzyme; Provisional; Region: PRK12313 767468000087 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 767468000088 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 767468000089 active site 767468000090 catalytic site [active] 767468000091 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 767468000092 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 767468000093 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 767468000094 ligand binding site; other site 767468000095 oligomer interface; other site 767468000096 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 767468000097 dimer interface [polypeptide binding]; other site 767468000098 N-terminal domain interface [polypeptide binding]; other site 767468000099 sulfate 1 binding site; other site 767468000100 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 767468000101 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 767468000102 ligand binding site; other site 767468000103 oligomer interface; other site 767468000104 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 767468000105 dimer interface [polypeptide binding]; other site 767468000106 N-terminal domain interface [polypeptide binding]; other site 767468000107 sulfate 1 binding site; other site 767468000108 glycogen synthase; Provisional; Region: glgA; PRK00654 767468000109 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 767468000110 ADP-binding pocket [chemical binding]; other site 767468000111 homodimer interface [polypeptide binding]; other site 767468000112 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 767468000113 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 767468000114 active site pocket [active] 767468000115 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 767468000116 active site 767468000117 homodimer interface [polypeptide binding]; other site 767468000118 catalytic site [active] 767468000119 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 767468000120 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468000121 active site 767468000122 motif I; other site 767468000123 motif II; other site 767468000124 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767468000125 beta-phosphoglucomutase; Region: bPGM; TIGR01990 767468000126 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468000127 motif II; other site 767468000128 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 767468000129 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 767468000130 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 767468000131 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 767468000132 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 767468000133 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 767468000134 DNA-binding site [nucleotide binding]; DNA binding site 767468000135 RNA-binding motif; other site 767468000136 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767468000137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767468000138 active site 767468000139 phosphorylation site [posttranslational modification] 767468000140 intermolecular recognition site; other site 767468000141 dimerization interface [polypeptide binding]; other site 767468000142 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767468000143 DNA binding site [nucleotide binding] 767468000144 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 767468000145 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767468000146 dimerization interface [polypeptide binding]; other site 767468000147 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767468000148 putative active site [active] 767468000149 heme pocket [chemical binding]; other site 767468000150 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767468000151 dimer interface [polypeptide binding]; other site 767468000152 phosphorylation site [posttranslational modification] 767468000153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767468000154 ATP binding site [chemical binding]; other site 767468000155 Mg2+ binding site [ion binding]; other site 767468000156 G-X-G motif; other site 767468000157 YycH protein; Region: YycH; pfam07435 767468000158 YycH protein; Region: YycI; pfam09648 767468000159 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 767468000160 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 767468000161 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 767468000162 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 767468000163 protein binding site [polypeptide binding]; other site 767468000164 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 767468000165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468000166 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 767468000167 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 767468000168 NAD(P) binding site [chemical binding]; other site 767468000169 catalytic residues [active] 767468000170 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 767468000171 Uncharacterized conserved protein [Function unknown]; Region: COG3586 767468000172 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 767468000173 putative uracil binding site [chemical binding]; other site 767468000174 putative active site [active] 767468000175 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 767468000176 FMN binding site [chemical binding]; other site 767468000177 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 767468000178 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 767468000179 Predicted flavoprotein [General function prediction only]; Region: COG0431 767468000180 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767468000181 FAD binding domain; Region: FAD_binding_2; pfam00890 767468000182 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 767468000183 FMN-binding domain; Region: FMN_bind; cl01081 767468000184 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 767468000185 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 767468000186 transmembrane helices; other site 767468000187 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468000188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767468000189 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 767468000190 dimerization interface [polypeptide binding]; other site 767468000191 flavodoxin; Provisional; Region: PRK06242 767468000192 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 767468000193 Low molecular weight phosphatase family; Region: LMWPc; cd00115 767468000194 active site 767468000195 hypothetical protein; Provisional; Region: PRK06194 767468000196 classical (c) SDRs; Region: SDR_c; cd05233 767468000197 NAD(P) binding site [chemical binding]; other site 767468000198 active site 767468000199 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 767468000200 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 767468000201 dimer interface [polypeptide binding]; other site 767468000202 FMN binding site [chemical binding]; other site 767468000203 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 767468000204 beta-phosphoglucomutase; Region: bPGM; TIGR01990 767468000205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468000206 motif II; other site 767468000207 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 767468000208 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 767468000209 active site 767468000210 Uncharacterized conserved protein [Function unknown]; Region: COG2966 767468000211 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 767468000212 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 767468000213 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 767468000214 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 767468000215 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 767468000216 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 767468000217 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 767468000218 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 767468000219 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 767468000220 catalytic triad [active] 767468000221 Predicted transcriptional regulator [Transcription]; Region: COG2378 767468000222 HTH domain; Region: HTH_11; pfam08279 767468000223 WYL domain; Region: WYL; pfam13280 767468000224 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 767468000225 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 767468000226 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 767468000227 G1 box; other site 767468000228 putative GEF interaction site [polypeptide binding]; other site 767468000229 GTP/Mg2+ binding site [chemical binding]; other site 767468000230 Switch I region; other site 767468000231 G2 box; other site 767468000232 G3 box; other site 767468000233 Switch II region; other site 767468000234 G4 box; other site 767468000235 G5 box; other site 767468000236 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 767468000237 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 767468000238 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 767468000239 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 767468000240 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 767468000241 EamA-like transporter family; Region: EamA; pfam00892 767468000242 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 767468000243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468000244 Coenzyme A binding pocket [chemical binding]; other site 767468000245 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 767468000246 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 767468000247 potential catalytic triad [active] 767468000248 conserved cys residue [active] 767468000249 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 767468000250 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 767468000251 putative NAD(P) binding site [chemical binding]; other site 767468000252 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767468000253 dimerization interface [polypeptide binding]; other site 767468000254 putative DNA binding site [nucleotide binding]; other site 767468000255 putative Zn2+ binding site [ion binding]; other site 767468000256 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 767468000257 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 767468000258 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 767468000259 hypothetical protein; Validated; Region: PRK02101 767468000260 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767468000261 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767468000262 peptide binding site [polypeptide binding]; other site 767468000263 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 767468000264 active site 767468000265 NTP binding site [chemical binding]; other site 767468000266 metal binding triad [ion binding]; metal-binding site 767468000267 antibiotic binding site [chemical binding]; other site 767468000268 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 767468000269 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767468000270 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 767468000271 Walker A/P-loop; other site 767468000272 ATP binding site [chemical binding]; other site 767468000273 Q-loop/lid; other site 767468000274 ABC transporter signature motif; other site 767468000275 Walker B; other site 767468000276 D-loop; other site 767468000277 H-loop/switch region; other site 767468000278 Cobalt transport protein; Region: CbiQ; cl00463 767468000279 cobalt transport protein CbiM; Provisional; Region: PRK07331 767468000280 cobalt transport protein CbiM; Provisional; Region: PRK11909 767468000281 PDGLE domain; Region: PDGLE; pfam13190 767468000282 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 767468000283 putative switch regulator; other site 767468000284 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 767468000285 non-specific DNA interactions [nucleotide binding]; other site 767468000286 DNA binding site [nucleotide binding] 767468000287 sequence specific DNA binding site [nucleotide binding]; other site 767468000288 putative cAMP binding site [chemical binding]; other site 767468000289 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 767468000290 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 767468000291 AIR carboxylase; Region: AIRC; smart01001 767468000292 Protein of unknown function DUF111; Region: DUF111; pfam01969 767468000293 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 767468000294 amphipathic channel; other site 767468000295 Asn-Pro-Ala signature motifs; other site 767468000296 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 767468000297 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 767468000298 Ligand Binding Site [chemical binding]; other site 767468000299 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 767468000300 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 767468000301 putative NAD(P) binding site [chemical binding]; other site 767468000302 substrate binding site [chemical binding]; other site 767468000303 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 767468000304 substrate binding site [chemical binding]; other site 767468000305 multimerization interface [polypeptide binding]; other site 767468000306 ATP binding site [chemical binding]; other site 767468000307 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 767468000308 dimer interface [polypeptide binding]; other site 767468000309 substrate binding site [chemical binding]; other site 767468000310 ATP binding site [chemical binding]; other site 767468000311 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 767468000312 thiamine phosphate binding site [chemical binding]; other site 767468000313 active site 767468000314 pyrophosphate binding site [ion binding]; other site 767468000315 putative hydroxymethylpyrimidine transporter CytX; Region: thia_cytX; TIGR02358 767468000316 Na binding site [ion binding]; other site 767468000317 Peptidase C26; Region: Peptidase_C26; pfam07722 767468000318 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 767468000319 catalytic triad [active] 767468000320 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 767468000321 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 767468000322 nudix motif; other site 767468000323 putative transport protein YifK; Provisional; Region: PRK10746 767468000324 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 767468000325 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 767468000326 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 767468000327 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767468000328 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 767468000329 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767468000330 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 767468000331 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 767468000332 PspC domain; Region: PspC; pfam04024 767468000333 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767468000334 Predicted flavoprotein [General function prediction only]; Region: COG0431 767468000335 Transcriptional regulators [Transcription]; Region: MarR; COG1846 767468000336 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 767468000337 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 767468000338 putative dimer interface [polypeptide binding]; other site 767468000339 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 767468000340 LytTr DNA-binding domain; Region: LytTR; pfam04397 767468000341 drug efflux system protein MdtG; Provisional; Region: PRK09874 767468000342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468000343 putative substrate translocation pore; other site 767468000344 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767468000345 dimerization interface [polypeptide binding]; other site 767468000346 putative DNA binding site [nucleotide binding]; other site 767468000347 putative Zn2+ binding site [ion binding]; other site 767468000348 cyanate transporter; Region: CynX; TIGR00896 767468000349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468000350 putative substrate translocation pore; other site 767468000351 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767468000352 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767468000353 active site 767468000354 catalytic tetrad [active] 767468000355 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767468000356 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767468000357 active site 767468000358 catalytic tetrad [active] 767468000359 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 767468000360 myosin-cross-reactive antigen; Provisional; Region: PRK13977 767468000361 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 767468000362 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 767468000363 putative active site [active] 767468000364 putative FMN binding site [chemical binding]; other site 767468000365 putative substrate binding site [chemical binding]; other site 767468000366 putative catalytic residue [active] 767468000367 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 767468000368 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767468000369 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767468000370 Walker A/P-loop; other site 767468000371 ATP binding site [chemical binding]; other site 767468000372 Q-loop/lid; other site 767468000373 ABC transporter signature motif; other site 767468000374 Walker B; other site 767468000375 D-loop; other site 767468000376 H-loop/switch region; other site 767468000377 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 767468000378 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767468000379 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767468000380 Walker A/P-loop; other site 767468000381 ATP binding site [chemical binding]; other site 767468000382 Q-loop/lid; other site 767468000383 ABC transporter signature motif; other site 767468000384 Walker B; other site 767468000385 D-loop; other site 767468000386 H-loop/switch region; other site 767468000387 hypothetical protein; Provisional; Region: PRK13661 767468000388 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 767468000389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767468000390 DNA-binding site [nucleotide binding]; DNA binding site 767468000391 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 767468000392 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 767468000393 classical (c) SDRs; Region: SDR_c; cd05233 767468000394 NAD(P) binding site [chemical binding]; other site 767468000395 active site 767468000396 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767468000397 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767468000398 Walker A/P-loop; other site 767468000399 ATP binding site [chemical binding]; other site 767468000400 Q-loop/lid; other site 767468000401 ABC transporter signature motif; other site 767468000402 Walker B; other site 767468000403 D-loop; other site 767468000404 H-loop/switch region; other site 767468000405 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 767468000406 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 767468000407 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468000408 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767468000409 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 767468000410 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 767468000411 active site 767468000412 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 767468000413 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 767468000414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767468000415 probable dihydroxyacetone kinase DhaK1b subunit; Region: dhaK1b; TIGR02362 767468000416 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 767468000417 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 767468000418 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 767468000419 DAK2 domain; Region: Dak2; cl03685 767468000420 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 767468000421 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 767468000422 amphipathic channel; other site 767468000423 Asn-Pro-Ala signature motifs; other site 767468000424 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767468000425 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767468000426 DNA binding site [nucleotide binding] 767468000427 domain linker motif; other site 767468000428 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 767468000429 putative dimerization interface [polypeptide binding]; other site 767468000430 putative ligand binding site [chemical binding]; other site 767468000431 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767468000432 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767468000433 DNA binding site [nucleotide binding] 767468000434 domain linker motif; other site 767468000435 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 767468000436 ligand binding site [chemical binding]; other site 767468000437 dimerization interface [polypeptide binding]; other site 767468000438 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 767468000439 active site 767468000440 catalytic site [active] 767468000441 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468000442 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468000443 Integrase core domain; Region: rve; pfam00665 767468000444 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 767468000445 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 767468000446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468000447 dimer interface [polypeptide binding]; other site 767468000448 conserved gate region; other site 767468000449 putative PBP binding loops; other site 767468000450 ABC-ATPase subunit interface; other site 767468000451 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 767468000452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468000453 dimer interface [polypeptide binding]; other site 767468000454 conserved gate region; other site 767468000455 putative PBP binding loops; other site 767468000456 ABC-ATPase subunit interface; other site 767468000457 Predicted integral membrane protein [Function unknown]; Region: COG5521 767468000458 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 767468000459 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 767468000460 active site 767468000461 catalytic site [active] 767468000462 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 767468000463 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 767468000464 Walker A/P-loop; other site 767468000465 ATP binding site [chemical binding]; other site 767468000466 Q-loop/lid; other site 767468000467 ABC transporter signature motif; other site 767468000468 Walker B; other site 767468000469 D-loop; other site 767468000470 H-loop/switch region; other site 767468000471 TOBE domain; Region: TOBE_2; pfam08402 767468000472 maltose phosphorylase; Provisional; Region: PRK13807 767468000473 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 767468000474 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 767468000475 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 767468000476 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 767468000477 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 767468000478 putative active site [active] 767468000479 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 767468000480 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 767468000481 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 767468000482 sugar binding site [chemical binding]; other site 767468000483 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468000484 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468000485 Integrase core domain; Region: rve; pfam00665 767468000486 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 767468000487 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 767468000488 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 767468000489 nucleotide binding site [chemical binding]; other site 767468000490 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 767468000491 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 767468000492 Melibiase; Region: Melibiase; pfam02065 767468000493 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 767468000494 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767468000495 active site turn [active] 767468000496 phosphorylation site [posttranslational modification] 767468000497 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767468000498 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 767468000499 HPr interaction site; other site 767468000500 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767468000501 active site 767468000502 phosphorylation site [posttranslational modification] 767468000503 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 767468000504 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 767468000505 substrate binding [chemical binding]; other site 767468000506 active site 767468000507 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 767468000508 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767468000509 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767468000510 DNA binding site [nucleotide binding] 767468000511 domain linker motif; other site 767468000512 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 767468000513 dimerization interface [polypeptide binding]; other site 767468000514 ligand binding site [chemical binding]; other site 767468000515 sodium binding site [ion binding]; other site 767468000516 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 767468000517 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 767468000518 Ca binding site [ion binding]; other site 767468000519 active site 767468000520 catalytic site [active] 767468000521 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 767468000522 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 767468000523 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 767468000524 putative NAD(P) binding site [chemical binding]; other site 767468000525 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 767468000526 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 767468000527 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 767468000528 Ca binding site [ion binding]; other site 767468000529 active site 767468000530 catalytic site [active] 767468000531 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 767468000532 Cna protein B-type domain; Region: Cna_B; pfam05738 767468000533 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 767468000534 domain interaction interfaces [polypeptide binding]; other site 767468000535 Cna protein B-type domain; Region: Cna_B; pfam05738 767468000536 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767468000537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468000538 non-specific DNA binding site [nucleotide binding]; other site 767468000539 salt bridge; other site 767468000540 sequence-specific DNA binding site [nucleotide binding]; other site 767468000541 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767468000542 peptide binding site [polypeptide binding]; other site 767468000543 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 767468000544 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767468000545 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767468000546 peptide binding site [polypeptide binding]; other site 767468000547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 767468000548 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 767468000549 putative ligand binding site [chemical binding]; other site 767468000550 putative NAD binding site [chemical binding]; other site 767468000551 putative catalytic site [active] 767468000552 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 767468000553 L-serine binding site [chemical binding]; other site 767468000554 ACT domain interface; other site 767468000555 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 767468000556 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767468000557 catalytic residue [active] 767468000558 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767468000559 catalytic core [active] 767468000560 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767468000561 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767468000562 active site 767468000563 catalytic tetrad [active] 767468000564 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 767468000565 Domain of unknown function (DU1801); Region: DUF1801; cl17490 767468000566 Domain of unknown function (DUF814); Region: DUF814; pfam05670 767468000567 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 767468000568 propionate/acetate kinase; Provisional; Region: PRK12379 767468000569 CrcB-like protein; Region: CRCB; cl09114 767468000570 CrcB-like protein; Region: CRCB; cl09114 767468000571 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 767468000572 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767468000573 ABC transporter; Region: ABC_tran_2; pfam12848 767468000574 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767468000575 ABC transporter; Region: ABC_tran; pfam00005 767468000576 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767468000577 MULE transposase domain; Region: MULE; pfam10551 767468000578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468000579 H-loop/switch region; other site 767468000580 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468000581 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468000582 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 767468000583 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 767468000584 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767468000585 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767468000586 Walker A/P-loop; other site 767468000587 ATP binding site [chemical binding]; other site 767468000588 Q-loop/lid; other site 767468000589 ABC transporter signature motif; other site 767468000590 Walker B; other site 767468000591 D-loop; other site 767468000592 H-loop/switch region; other site 767468000593 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767468000594 AAA domain; Region: AAA_23; pfam13476 767468000595 Walker A/P-loop; other site 767468000596 ATP binding site [chemical binding]; other site 767468000597 ABC transporter; Region: ABC_tran; pfam00005 767468000598 Q-loop/lid; other site 767468000599 ABC transporter signature motif; other site 767468000600 Walker B; other site 767468000601 D-loop; other site 767468000602 H-loop/switch region; other site 767468000603 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 767468000604 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 767468000605 catalytic residues [active] 767468000606 dimer interface [polypeptide binding]; other site 767468000607 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767468000608 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767468000609 active site 767468000610 catalytic tetrad [active] 767468000611 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 767468000612 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 767468000613 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 767468000614 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767468000615 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468000616 non-specific DNA binding site [nucleotide binding]; other site 767468000617 salt bridge; other site 767468000618 sequence-specific DNA binding site [nucleotide binding]; other site 767468000619 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 767468000620 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 767468000621 active site 767468000622 trimer interface [polypeptide binding]; other site 767468000623 allosteric site; other site 767468000624 active site lid [active] 767468000625 hexamer (dimer of trimers) interface [polypeptide binding]; other site 767468000626 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468000627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468000628 putative substrate translocation pore; other site 767468000629 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 767468000630 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 767468000631 Predicted oxidoreductase [General function prediction only]; Region: COG3573 767468000632 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 767468000633 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767468000634 Peptidase family C69; Region: Peptidase_C69; pfam03577 767468000635 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 767468000636 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 767468000637 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 767468000638 active site 767468000639 P-loop; other site 767468000640 phosphorylation site [posttranslational modification] 767468000641 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 767468000642 active site 767468000643 P-loop; other site 767468000644 phosphorylation site [posttranslational modification] 767468000645 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 767468000646 PRD domain; Region: PRD; pfam00874 767468000647 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 767468000648 active site 767468000649 P-loop; other site 767468000650 phosphorylation site [posttranslational modification] 767468000651 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 767468000652 active site 767468000653 phosphorylation site [posttranslational modification] 767468000654 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 767468000655 active site 767468000656 phosphorylation site [posttranslational modification] 767468000657 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 767468000658 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 767468000659 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 767468000660 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 767468000661 DNA binding residues [nucleotide binding] 767468000662 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 767468000663 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 767468000664 catalytic residues [active] 767468000665 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 767468000666 active site 767468000667 multimer interface [polypeptide binding]; other site 767468000668 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 767468000669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 767468000670 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767468000671 Predicted flavoprotein [General function prediction only]; Region: COG0431 767468000672 serine O-acetyltransferase; Region: cysE; TIGR01172 767468000673 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 767468000674 trimer interface [polypeptide binding]; other site 767468000675 active site 767468000676 substrate binding site [chemical binding]; other site 767468000677 CoA binding site [chemical binding]; other site 767468000678 cystathionine beta-lyase; Provisional; Region: PRK07671 767468000679 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 767468000680 homodimer interface [polypeptide binding]; other site 767468000681 substrate-cofactor binding pocket; other site 767468000682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468000683 catalytic residue [active] 767468000684 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 767468000685 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 767468000686 dimer interface [polypeptide binding]; other site 767468000687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468000688 catalytic residue [active] 767468000689 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 767468000690 methionine aminopeptidase; Provisional; Region: PRK08671 767468000691 active site 767468000692 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 767468000693 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 767468000694 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 767468000695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767468000696 DNA-binding site [nucleotide binding]; DNA binding site 767468000697 UTRA domain; Region: UTRA; pfam07702 767468000698 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 767468000699 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 767468000700 Ca binding site [ion binding]; other site 767468000701 active site 767468000702 catalytic site [active] 767468000703 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 767468000704 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 767468000705 HPr interaction site; other site 767468000706 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767468000707 active site 767468000708 phosphorylation site [posttranslational modification] 767468000709 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 767468000710 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767468000711 active site turn [active] 767468000712 phosphorylation site [posttranslational modification] 767468000713 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767468000714 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 767468000715 HPr interaction site; other site 767468000716 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767468000717 active site 767468000718 phosphorylation site [posttranslational modification] 767468000719 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 767468000720 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767468000721 active site turn [active] 767468000722 phosphorylation site [posttranslational modification] 767468000723 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767468000724 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767468000725 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 767468000726 active site 767468000727 nucleotide binding site [chemical binding]; other site 767468000728 HIGH motif; other site 767468000729 KMSKS motif; other site 767468000730 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 767468000731 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 767468000732 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 767468000733 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 767468000734 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 767468000735 putative ADP-binding pocket [chemical binding]; other site 767468000736 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767468000737 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 767468000738 Flavoprotein; Region: Flavoprotein; pfam02441 767468000739 Predicted transcriptional regulator [Transcription]; Region: COG1959 767468000740 Transcriptional regulator; Region: Rrf2; pfam02082 767468000741 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468000742 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767468000743 manganese transport protein MntH; Reviewed; Region: PRK00701 767468000744 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 767468000745 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 767468000746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468000747 putative substrate translocation pore; other site 767468000748 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 767468000749 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 767468000750 DNA binding residues [nucleotide binding] 767468000751 putative dimer interface [polypeptide binding]; other site 767468000752 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767468000753 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767468000754 dimer interface [polypeptide binding]; other site 767468000755 phosphorylation site [posttranslational modification] 767468000756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767468000757 ATP binding site [chemical binding]; other site 767468000758 Mg2+ binding site [ion binding]; other site 767468000759 G-X-G motif; other site 767468000760 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767468000761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767468000762 active site 767468000763 phosphorylation site [posttranslational modification] 767468000764 intermolecular recognition site; other site 767468000765 dimerization interface [polypeptide binding]; other site 767468000766 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767468000767 DNA binding site [nucleotide binding] 767468000768 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 767468000769 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 767468000770 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 767468000771 putative active site [active] 767468000772 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 767468000773 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 767468000774 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 767468000775 FAD binding domain; Region: FAD_binding_4; pfam01565 767468000776 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 767468000777 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 767468000778 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 767468000779 synthetase active site [active] 767468000780 NTP binding site [chemical binding]; other site 767468000781 metal binding site [ion binding]; metal-binding site 767468000782 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 767468000783 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767468000784 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 767468000785 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 767468000786 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 767468000787 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 767468000788 Cation efflux family; Region: Cation_efflux; cl00316 767468000789 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 767468000790 legume lectins; Region: lectin_L-type; cl14058 767468000791 homotetramer interaction site [polypeptide binding]; other site 767468000792 carbohydrate binding site [chemical binding]; other site 767468000793 metal binding site [ion binding]; metal-binding site 767468000794 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767468000795 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 767468000796 FtsX-like permease family; Region: FtsX; pfam02687 767468000797 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767468000798 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767468000799 Walker A/P-loop; other site 767468000800 ATP binding site [chemical binding]; other site 767468000801 Q-loop/lid; other site 767468000802 ABC transporter signature motif; other site 767468000803 Walker B; other site 767468000804 D-loop; other site 767468000805 H-loop/switch region; other site 767468000806 CAAX protease self-immunity; Region: Abi; pfam02517 767468000807 CAAX protease self-immunity; Region: Abi; pfam02517 767468000808 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767468000809 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 767468000810 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767468000811 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 767468000812 lipoyl attachment site [posttranslational modification]; other site 767468000813 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 767468000814 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767468000815 DEAD_2; Region: DEAD_2; pfam06733 767468000816 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 767468000817 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 767468000818 propionate/acetate kinase; Provisional; Region: PRK12379 767468000819 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767468000820 MarR family; Region: MarR_2; pfam12802 767468000821 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 767468000822 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 767468000823 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767468000824 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 767468000825 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 767468000826 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 767468000827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468000828 dimer interface [polypeptide binding]; other site 767468000829 conserved gate region; other site 767468000830 putative PBP binding loops; other site 767468000831 ABC-ATPase subunit interface; other site 767468000832 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 767468000833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468000834 dimer interface [polypeptide binding]; other site 767468000835 conserved gate region; other site 767468000836 putative PBP binding loops; other site 767468000837 ABC-ATPase subunit interface; other site 767468000838 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 767468000839 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 767468000840 Walker A/P-loop; other site 767468000841 ATP binding site [chemical binding]; other site 767468000842 Q-loop/lid; other site 767468000843 ABC transporter signature motif; other site 767468000844 Walker B; other site 767468000845 D-loop; other site 767468000846 H-loop/switch region; other site 767468000847 TOBE domain; Region: TOBE_2; pfam08402 767468000848 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767468000849 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468000850 non-specific DNA binding site [nucleotide binding]; other site 767468000851 salt bridge; other site 767468000852 sequence-specific DNA binding site [nucleotide binding]; other site 767468000853 Cupin domain; Region: Cupin_2; pfam07883 767468000854 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 767468000855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468000856 Coenzyme A binding pocket [chemical binding]; other site 767468000857 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 767468000858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468000859 Coenzyme A binding pocket [chemical binding]; other site 767468000860 Predicted transcriptional regulators [Transcription]; Region: COG1725 767468000861 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767468000862 DNA-binding site [nucleotide binding]; DNA binding site 767468000863 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 767468000864 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767468000865 Walker A/P-loop; other site 767468000866 ATP binding site [chemical binding]; other site 767468000867 Q-loop/lid; other site 767468000868 ABC transporter signature motif; other site 767468000869 Walker B; other site 767468000870 D-loop; other site 767468000871 H-loop/switch region; other site 767468000872 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468000873 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468000874 Integrase core domain; Region: rve; pfam00665 767468000875 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 767468000876 putative catalytic cysteine [active] 767468000877 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 767468000878 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 767468000879 intersubunit interface [polypeptide binding]; other site 767468000880 active site 767468000881 zinc binding site [ion binding]; other site 767468000882 Na+ binding site [ion binding]; other site 767468000883 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 767468000884 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 767468000885 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 767468000886 HflK protein; Region: hflK; TIGR01933 767468000887 Peptidase family C69; Region: Peptidase_C69; pfam03577 767468000888 BioY family; Region: BioY; pfam02632 767468000889 Biotin operon repressor [Transcription]; Region: BirA; COG1654 767468000890 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 767468000891 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 767468000892 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 767468000893 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 767468000894 CHY zinc finger; Region: zf-CHY; pfam05495 767468000895 transaminase; Reviewed; Region: PRK08068 767468000896 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767468000897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468000898 homodimer interface [polypeptide binding]; other site 767468000899 catalytic residue [active] 767468000900 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 767468000901 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 767468000902 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 767468000903 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 767468000904 Walker A/P-loop; other site 767468000905 ATP binding site [chemical binding]; other site 767468000906 Q-loop/lid; other site 767468000907 ABC transporter signature motif; other site 767468000908 Walker B; other site 767468000909 D-loop; other site 767468000910 H-loop/switch region; other site 767468000911 type II secretion system protein F; Region: GspF; TIGR02120 767468000912 Predicted transcriptional regulators [Transcription]; Region: COG1695 767468000913 Transcriptional regulator PadR-like family; Region: PadR; cl17335 767468000914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468000915 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468000916 putative substrate translocation pore; other site 767468000917 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 767468000918 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468000919 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468000920 Integrase core domain; Region: rve; pfam00665 767468000921 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 767468000922 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767468000923 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 767468000924 NAD binding site [chemical binding]; other site 767468000925 dimer interface [polypeptide binding]; other site 767468000926 substrate binding site [chemical binding]; other site 767468000927 ATP-dependent protease Lon; Provisional; Region: PRK13765 767468000928 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 767468000929 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767468000930 active site 767468000931 dimer interface [polypeptide binding]; other site 767468000932 multicopper oxidase; Provisional; Region: PRK10965 767468000933 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 767468000934 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 767468000935 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 767468000936 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 767468000937 substrate binding site [chemical binding]; other site 767468000938 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 767468000939 Uncharacterized conserved protein [Function unknown]; Region: COG3410 767468000940 Transcriptional regulator; Region: Rrf2; pfam02082 767468000941 Rrf2 family protein; Region: rrf2_super; TIGR00738 767468000942 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 767468000943 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 767468000944 carboxyltransferase (CT) interaction site; other site 767468000945 biotinylation site [posttranslational modification]; other site 767468000946 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 767468000947 active site 767468000948 tetramer interface [polypeptide binding]; other site 767468000949 short chain dehydrogenase; Validated; Region: PRK06182 767468000950 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 767468000951 NADP binding site [chemical binding]; other site 767468000952 active site 767468000953 steroid binding site; other site 767468000954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468000955 dimer interface [polypeptide binding]; other site 767468000956 conserved gate region; other site 767468000957 ABC-ATPase subunit interface; other site 767468000958 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 767468000959 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 767468000960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468000961 Walker A/P-loop; other site 767468000962 ATP binding site [chemical binding]; other site 767468000963 Q-loop/lid; other site 767468000964 ABC transporter signature motif; other site 767468000965 Walker B; other site 767468000966 D-loop; other site 767468000967 H-loop/switch region; other site 767468000968 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 767468000969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767468000970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767468000971 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767468000972 glycerol kinase; Provisional; Region: glpK; PRK00047 767468000973 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 767468000974 N- and C-terminal domain interface [polypeptide binding]; other site 767468000975 active site 767468000976 MgATP binding site [chemical binding]; other site 767468000977 catalytic site [active] 767468000978 metal binding site [ion binding]; metal-binding site 767468000979 glycerol binding site [chemical binding]; other site 767468000980 homotetramer interface [polypeptide binding]; other site 767468000981 homodimer interface [polypeptide binding]; other site 767468000982 FBP binding site [chemical binding]; other site 767468000983 protein IIAGlc interface [polypeptide binding]; other site 767468000984 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 767468000985 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 767468000986 amphipathic channel; other site 767468000987 Asn-Pro-Ala signature motifs; other site 767468000988 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 767468000989 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 767468000990 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767468000991 MULE transposase domain; Region: MULE; pfam10551 767468000992 CAAX protease self-immunity; Region: Abi; pfam02517 767468000993 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 767468000994 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 767468000995 putative active site [active] 767468000996 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767468000997 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468000998 Walker A/P-loop; other site 767468000999 ATP binding site [chemical binding]; other site 767468001000 Q-loop/lid; other site 767468001001 ABC transporter signature motif; other site 767468001002 Walker B; other site 767468001003 D-loop; other site 767468001004 H-loop/switch region; other site 767468001005 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 767468001006 HlyD family secretion protein; Region: HlyD_3; pfam13437 767468001007 CAAX protease self-immunity; Region: Abi; pfam02517 767468001008 CAAX protease self-immunity; Region: Abi; pfam02517 767468001009 CAAX protease self-immunity; Region: Abi; pfam02517 767468001010 CAAX protease self-immunity; Region: Abi; pfam02517 767468001011 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 767468001012 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 767468001013 sequence-specific DNA binding site [nucleotide binding]; other site 767468001014 salt bridge; other site 767468001015 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 767468001016 Part of AAA domain; Region: AAA_19; pfam13245 767468001017 Family description; Region: UvrD_C_2; pfam13538 767468001018 Predicted amidohydrolase [General function prediction only]; Region: COG0388 767468001019 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 767468001020 putative active site [active] 767468001021 catalytic triad [active] 767468001022 putative dimer interface [polypeptide binding]; other site 767468001023 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 767468001024 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 767468001025 active site 767468001026 HIGH motif; other site 767468001027 dimer interface [polypeptide binding]; other site 767468001028 KMSKS motif; other site 767468001029 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 767468001030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767468001031 DNA-binding site [nucleotide binding]; DNA binding site 767468001032 UTRA domain; Region: UTRA; pfam07702 767468001033 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 767468001034 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 767468001035 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 767468001036 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 767468001037 PemK-like protein; Region: PemK; pfam02452 767468001038 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 767468001039 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 767468001040 FMN binding site [chemical binding]; other site 767468001041 active site 767468001042 catalytic residues [active] 767468001043 substrate binding site [chemical binding]; other site 767468001044 exopolyphosphatase; Region: exo_poly_only; TIGR03706 767468001045 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 767468001046 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 767468001047 homodimer interface [polypeptide binding]; other site 767468001048 catalytic residues [active] 767468001049 NAD binding site [chemical binding]; other site 767468001050 substrate binding pocket [chemical binding]; other site 767468001051 flexible flap; other site 767468001052 NAD-dependent deacetylase; Provisional; Region: PRK00481 767468001053 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 767468001054 NAD+ binding site [chemical binding]; other site 767468001055 substrate binding site [chemical binding]; other site 767468001056 putative Zn binding site [ion binding]; other site 767468001057 Protein of unknown function DUF72; Region: DUF72; pfam01904 767468001058 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 767468001059 nudix motif; other site 767468001060 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 767468001061 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 767468001062 HIGH motif; other site 767468001063 active site 767468001064 KMSKS motif; other site 767468001065 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 767468001066 tRNA binding surface [nucleotide binding]; other site 767468001067 anticodon binding site; other site 767468001068 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 767468001069 dimer interface [polypeptide binding]; other site 767468001070 putative tRNA-binding site [nucleotide binding]; other site 767468001071 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 767468001072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468001073 putative substrate translocation pore; other site 767468001074 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 767468001075 active site 767468001076 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 767468001077 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 767468001078 putative active site [active] 767468001079 putative metal binding site [ion binding]; other site 767468001080 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 767468001081 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 767468001082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767468001083 S-adenosylmethionine binding site [chemical binding]; other site 767468001084 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 767468001085 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 767468001086 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767468001087 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 767468001088 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 767468001089 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767468001090 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 767468001091 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 767468001092 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 767468001093 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 767468001094 putative PBP binding regions; other site 767468001095 ABC-ATPase subunit interface; other site 767468001096 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 767468001097 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468001098 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468001099 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 767468001100 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 767468001101 pur operon repressor; Provisional; Region: PRK09213 767468001102 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 767468001103 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767468001104 active site 767468001105 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 767468001106 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 767468001107 Substrate binding site; other site 767468001108 Mg++ binding site; other site 767468001109 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 767468001110 active site 767468001111 substrate binding site [chemical binding]; other site 767468001112 CoA binding site [chemical binding]; other site 767468001113 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 767468001114 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 767468001115 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 767468001116 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767468001117 active site 767468001118 Uncharacterized conserved protein [Function unknown]; Region: COG1434 767468001119 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 767468001120 putative active site [active] 767468001121 putative transposase OrfB; Reviewed; Region: PHA02517 767468001122 HTH-like domain; Region: HTH_21; pfam13276 767468001123 Integrase core domain; Region: rve; pfam00665 767468001124 Integrase core domain; Region: rve_2; pfam13333 767468001125 Winged helix-turn helix; Region: HTH_29; pfam13551 767468001126 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468001127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767468001128 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468001129 sugar phosphate phosphatase; Provisional; Region: PRK10513 767468001130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468001131 active site 767468001132 motif I; other site 767468001133 motif II; other site 767468001134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468001135 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 767468001136 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767468001137 Zn2+ binding site [ion binding]; other site 767468001138 Mg2+ binding site [ion binding]; other site 767468001139 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 767468001140 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 767468001141 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 767468001142 CTP synthetase; Validated; Region: pyrG; PRK05380 767468001143 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 767468001144 Catalytic site [active] 767468001145 active site 767468001146 UTP binding site [chemical binding]; other site 767468001147 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 767468001148 active site 767468001149 putative oxyanion hole; other site 767468001150 catalytic triad [active] 767468001151 seryl-tRNA synthetase; Provisional; Region: PRK05431 767468001152 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 767468001153 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 767468001154 dimer interface [polypeptide binding]; other site 767468001155 active site 767468001156 motif 1; other site 767468001157 motif 2; other site 767468001158 motif 3; other site 767468001159 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 767468001160 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 767468001161 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 767468001162 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 767468001163 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 767468001164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 767468001165 YheO-like PAS domain; Region: PAS_6; pfam08348 767468001166 HTH domain; Region: HTH_22; pfam13309 767468001167 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 767468001168 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 767468001169 hinge; other site 767468001170 active site 767468001171 transcription termination factor Rho; Provisional; Region: rho; PRK09376 767468001172 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 767468001173 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 767468001174 RNA binding site [nucleotide binding]; other site 767468001175 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 767468001176 multimer interface [polypeptide binding]; other site 767468001177 Walker A motif; other site 767468001178 ATP binding site [chemical binding]; other site 767468001179 Walker B motif; other site 767468001180 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 767468001181 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 767468001182 active site 767468001183 catalytic site [active] 767468001184 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 767468001185 heat shock protein HtpX; Provisional; Region: PRK04897 767468001186 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 767468001187 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767468001188 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767468001189 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 767468001190 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767468001191 ATP binding site [chemical binding]; other site 767468001192 Mg++ binding site [ion binding]; other site 767468001193 motif III; other site 767468001194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767468001195 nucleotide binding region [chemical binding]; other site 767468001196 ATP-binding site [chemical binding]; other site 767468001197 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 767468001198 alanine racemase; Reviewed; Region: alr; PRK00053 767468001199 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 767468001200 active site 767468001201 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 767468001202 dimer interface [polypeptide binding]; other site 767468001203 substrate binding site [chemical binding]; other site 767468001204 catalytic residues [active] 767468001205 PemK-like protein; Region: PemK; pfam02452 767468001206 K+ potassium transporter; Region: K_trans; cl15781 767468001207 NMT1/THI5 like; Region: NMT1; pfam09084 767468001208 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767468001209 substrate binding pocket [chemical binding]; other site 767468001210 membrane-bound complex binding site; other site 767468001211 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 767468001212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468001213 dimer interface [polypeptide binding]; other site 767468001214 conserved gate region; other site 767468001215 putative PBP binding loops; other site 767468001216 ABC-ATPase subunit interface; other site 767468001217 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 767468001218 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 767468001219 Walker A/P-loop; other site 767468001220 ATP binding site [chemical binding]; other site 767468001221 Q-loop/lid; other site 767468001222 ABC transporter signature motif; other site 767468001223 Walker B; other site 767468001224 D-loop; other site 767468001225 H-loop/switch region; other site 767468001226 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 767468001227 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767468001228 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 767468001229 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 767468001230 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767468001231 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767468001232 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 767468001233 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 767468001234 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 767468001235 catalytic site [active] 767468001236 subunit interface [polypeptide binding]; other site 767468001237 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 767468001238 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 767468001239 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 767468001240 heterotetramer interface [polypeptide binding]; other site 767468001241 active site pocket [active] 767468001242 cleavage site 767468001243 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 767468001244 nucleotide binding site [chemical binding]; other site 767468001245 N-acetyl-L-glutamate binding site [chemical binding]; other site 767468001246 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 767468001247 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 767468001248 inhibitor-cofactor binding pocket; inhibition site 767468001249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468001250 catalytic residue [active] 767468001251 ornithine carbamoyltransferase; Validated; Region: PRK02102 767468001252 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 767468001253 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 767468001254 QueT transporter; Region: QueT; pfam06177 767468001255 FOG: CBS domain [General function prediction only]; Region: COG0517 767468001256 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 767468001257 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 767468001258 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 767468001259 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 767468001260 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 767468001261 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 767468001262 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767468001263 NAD binding site [chemical binding]; other site 767468001264 dimer interface [polypeptide binding]; other site 767468001265 substrate binding site [chemical binding]; other site 767468001266 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 767468001267 putative active site [active] 767468001268 catalytic residue [active] 767468001269 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 767468001270 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 767468001271 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767468001272 ATP binding site [chemical binding]; other site 767468001273 putative Mg++ binding site [ion binding]; other site 767468001274 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767468001275 nucleotide binding region [chemical binding]; other site 767468001276 ATP-binding site [chemical binding]; other site 767468001277 TRCF domain; Region: TRCF; pfam03461 767468001278 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 767468001279 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 767468001280 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767468001281 RNA binding surface [nucleotide binding]; other site 767468001282 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 767468001283 Septum formation initiator; Region: DivIC; pfam04977 767468001284 hypothetical protein; Provisional; Region: PRK08582 767468001285 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 767468001286 RNA binding site [nucleotide binding]; other site 767468001287 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 767468001288 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 767468001289 Ligand Binding Site [chemical binding]; other site 767468001290 TilS substrate C-terminal domain; Region: TilS_C; smart00977 767468001291 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767468001292 active site 767468001293 FtsH Extracellular; Region: FtsH_ext; pfam06480 767468001294 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 767468001295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468001296 Walker A motif; other site 767468001297 ATP binding site [chemical binding]; other site 767468001298 Walker B motif; other site 767468001299 arginine finger; other site 767468001300 Peptidase family M41; Region: Peptidase_M41; pfam01434 767468001301 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 767468001302 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 767468001303 dimerization interface [polypeptide binding]; other site 767468001304 domain crossover interface; other site 767468001305 redox-dependent activation switch; other site 767468001306 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 767468001307 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 767468001308 FMN binding site [chemical binding]; other site 767468001309 active site 767468001310 catalytic residues [active] 767468001311 substrate binding site [chemical binding]; other site 767468001312 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 767468001313 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 767468001314 dimer interface [polypeptide binding]; other site 767468001315 putative anticodon binding site; other site 767468001316 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 767468001317 motif 1; other site 767468001318 active site 767468001319 motif 2; other site 767468001320 motif 3; other site 767468001321 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 767468001322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468001323 putative substrate translocation pore; other site 767468001324 POT family; Region: PTR2; cl17359 767468001325 putative phosphoesterase; Region: acc_ester; TIGR03729 767468001326 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767468001327 Cupin domain; Region: Cupin_2; cl17218 767468001328 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 767468001329 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 767468001330 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767468001331 active site 767468001332 metal binding site [ion binding]; metal-binding site 767468001333 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 767468001334 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 767468001335 transmembrane helices; other site 767468001336 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 767468001337 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 767468001338 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 767468001339 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 767468001340 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 767468001341 active site 767468001342 dimer interface [polypeptide binding]; other site 767468001343 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 767468001344 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767468001345 DNA-binding site [nucleotide binding]; DNA binding site 767468001346 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 767468001347 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 767468001348 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 767468001349 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 767468001350 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 767468001351 active site 767468001352 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 767468001353 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 767468001354 homodimer interface [polypeptide binding]; other site 767468001355 NAD binding pocket [chemical binding]; other site 767468001356 ATP binding pocket [chemical binding]; other site 767468001357 Mg binding site [ion binding]; other site 767468001358 active-site loop [active] 767468001359 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 767468001360 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 767468001361 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767468001362 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 767468001363 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468001364 motif II; other site 767468001365 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 767468001366 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 767468001367 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 767468001368 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 767468001369 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 767468001370 RNA binding site [nucleotide binding]; other site 767468001371 hypothetical protein; Provisional; Region: PRK04351 767468001372 SprT homologues; Region: SprT; cl01182 767468001373 homoserine dehydrogenase; Provisional; Region: PRK06349 767468001374 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 767468001375 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 767468001376 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 767468001377 homoserine kinase; Provisional; Region: PRK01212 767468001378 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767468001379 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 767468001380 putative active site [active] 767468001381 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 767468001382 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 767468001383 active pocket/dimerization site; other site 767468001384 active site 767468001385 phosphorylation site [posttranslational modification] 767468001386 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 767468001387 active site 767468001388 phosphorylation site [posttranslational modification] 767468001389 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 767468001390 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 767468001391 Domain of unknown function (DUF956); Region: DUF956; pfam06115 767468001392 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 767468001393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468001394 Walker A motif; other site 767468001395 ATP binding site [chemical binding]; other site 767468001396 Walker B motif; other site 767468001397 arginine finger; other site 767468001398 Transcriptional antiterminator [Transcription]; Region: COG3933 767468001399 PRD domain; Region: PRD; pfam00874 767468001400 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 767468001401 active pocket/dimerization site; other site 767468001402 active site 767468001403 phosphorylation site [posttranslational modification] 767468001404 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 767468001405 active pocket/dimerization site; other site 767468001406 active site 767468001407 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 767468001408 active site 767468001409 phosphorylation site [posttranslational modification] 767468001410 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 767468001411 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 767468001412 dimer interface [polypeptide binding]; other site 767468001413 active site 767468001414 CoA binding pocket [chemical binding]; other site 767468001415 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 767468001416 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 767468001417 carboxyltransferase (CT) interaction site; other site 767468001418 biotinylation site [posttranslational modification]; other site 767468001419 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 767468001420 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767468001421 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767468001422 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 767468001423 acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515 767468001424 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767468001425 substrate binding site [chemical binding]; other site 767468001426 trimer interface [polypeptide binding]; other site 767468001427 oxyanion hole (OAH) forming residues; other site 767468001428 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 767468001429 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 767468001430 Membrane transport protein; Region: Mem_trans; pfam03547 767468001431 EamA-like transporter family; Region: EamA; pfam00892 767468001432 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 767468001433 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767468001434 catalytic core [active] 767468001435 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767468001436 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 767468001437 active site 767468001438 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 767468001439 trimer interface [polypeptide binding]; other site 767468001440 active site 767468001441 G bulge; other site 767468001442 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 767468001443 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767468001444 active site 767468001445 dimer interface [polypeptide binding]; other site 767468001446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468001447 Coenzyme A binding pocket [chemical binding]; other site 767468001448 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 767468001449 trimer interface [polypeptide binding]; other site 767468001450 active site 767468001451 DNA repair protein RadA; Provisional; Region: PRK11823 767468001452 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 767468001453 Walker A motif/ATP binding site; other site 767468001454 ATP binding site [chemical binding]; other site 767468001455 Walker B motif; other site 767468001456 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 767468001457 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 767468001458 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 767468001459 putative active site [active] 767468001460 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 767468001461 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 767468001462 active site 767468001463 HIGH motif; other site 767468001464 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 767468001465 active site 767468001466 KMSKS motif; other site 767468001467 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 767468001468 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 767468001469 active site 767468001470 HIGH motif; other site 767468001471 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 767468001472 KMSKS motif; other site 767468001473 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 767468001474 tRNA binding surface [nucleotide binding]; other site 767468001475 anticodon binding site; other site 767468001476 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 767468001477 active site 767468001478 metal binding site [ion binding]; metal-binding site 767468001479 dimerization interface [polypeptide binding]; other site 767468001480 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 767468001481 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 767468001482 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 767468001483 YacP-like NYN domain; Region: NYN_YacP; pfam05991 767468001484 RNA polymerase factor sigma-70; Validated; Region: PRK08295 767468001485 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767468001486 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 767468001487 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 767468001488 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 767468001489 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 767468001490 putative homodimer interface [polypeptide binding]; other site 767468001491 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 767468001492 heterodimer interface [polypeptide binding]; other site 767468001493 homodimer interface [polypeptide binding]; other site 767468001494 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767468001495 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 767468001496 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 767468001497 putative thiostrepton binding site; other site 767468001498 23S rRNA interface [nucleotide binding]; other site 767468001499 L7/L12 interface [polypeptide binding]; other site 767468001500 L25 interface [polypeptide binding]; other site 767468001501 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 767468001502 mRNA/rRNA interface [nucleotide binding]; other site 767468001503 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 767468001504 23S rRNA interface [nucleotide binding]; other site 767468001505 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 767468001506 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 767468001507 peripheral dimer interface [polypeptide binding]; other site 767468001508 core dimer interface [polypeptide binding]; other site 767468001509 L10 interface [polypeptide binding]; other site 767468001510 L11 interface [polypeptide binding]; other site 767468001511 putative EF-Tu interaction site [polypeptide binding]; other site 767468001512 putative EF-G interaction site [polypeptide binding]; other site 767468001513 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 767468001514 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 767468001515 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 767468001516 Predicted integral membrane protein [Function unknown]; Region: COG0392 767468001517 Uncharacterized conserved protein [Function unknown]; Region: COG2898 767468001518 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 767468001519 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 767468001520 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 767468001521 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 767468001522 dimer interface [polypeptide binding]; other site 767468001523 putative radical transfer pathway; other site 767468001524 diiron center [ion binding]; other site 767468001525 tyrosyl radical; other site 767468001526 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 767468001527 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 767468001528 Class I ribonucleotide reductase; Region: RNR_I; cd01679 767468001529 active site 767468001530 dimer interface [polypeptide binding]; other site 767468001531 catalytic residues [active] 767468001532 effector binding site; other site 767468001533 R2 peptide binding site; other site 767468001534 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 767468001535 catalytic residues [active] 767468001536 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 767468001537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767468001538 S-adenosylmethionine binding site [chemical binding]; other site 767468001539 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 767468001540 nucleoside/Zn binding site; other site 767468001541 dimer interface [polypeptide binding]; other site 767468001542 catalytic motif [active] 767468001543 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 767468001544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468001545 Walker A motif; other site 767468001546 ATP binding site [chemical binding]; other site 767468001547 Walker B motif; other site 767468001548 arginine finger; other site 767468001549 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 767468001550 hypothetical protein; Validated; Region: PRK00153 767468001551 recombination protein RecR; Reviewed; Region: recR; PRK00076 767468001552 RecR protein; Region: RecR; pfam02132 767468001553 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 767468001554 putative active site [active] 767468001555 putative metal-binding site [ion binding]; other site 767468001556 tetramer interface [polypeptide binding]; other site 767468001557 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 767468001558 thymidylate kinase; Validated; Region: tmk; PRK00698 767468001559 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 767468001560 TMP-binding site; other site 767468001561 ATP-binding site [chemical binding]; other site 767468001562 Protein of unknown function (DUF970); Region: DUF970; pfam06153 767468001563 DNA polymerase III subunit delta'; Validated; Region: PRK08058 767468001564 DNA polymerase III subunit delta'; Validated; Region: PRK08485 767468001565 Protein of unknown function (DUF972); Region: DUF972; pfam06156 767468001566 Predicted methyltransferases [General function prediction only]; Region: COG0313 767468001567 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 767468001568 putative SAM binding site [chemical binding]; other site 767468001569 putative homodimer interface [polypeptide binding]; other site 767468001570 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 767468001571 active site 767468001572 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 767468001573 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 767468001574 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 767468001575 NAD binding site [chemical binding]; other site 767468001576 homodimer interface [polypeptide binding]; other site 767468001577 active site 767468001578 substrate binding site [chemical binding]; other site 767468001579 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 767468001580 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767468001581 catalytic residue [active] 767468001582 phosphonoacetaldehyde hydrolase; Region: phosphonatase; TIGR01422 767468001583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468001584 motif II; other site 767468001585 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 767468001586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468001587 dimer interface [polypeptide binding]; other site 767468001588 conserved gate region; other site 767468001589 ABC-ATPase subunit interface; other site 767468001590 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 767468001591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468001592 dimer interface [polypeptide binding]; other site 767468001593 conserved gate region; other site 767468001594 ABC-ATPase subunit interface; other site 767468001595 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 767468001596 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 767468001597 Walker A/P-loop; other site 767468001598 ATP binding site [chemical binding]; other site 767468001599 Q-loop/lid; other site 767468001600 ABC transporter signature motif; other site 767468001601 Walker B; other site 767468001602 D-loop; other site 767468001603 H-loop/switch region; other site 767468001604 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 767468001605 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 767468001606 Glycoprotease family; Region: Peptidase_M22; pfam00814 767468001607 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 767468001608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468001609 Coenzyme A binding pocket [chemical binding]; other site 767468001610 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 767468001611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468001612 Coenzyme A binding pocket [chemical binding]; other site 767468001613 UGMP family protein; Validated; Region: PRK09604 767468001614 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 767468001615 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 767468001616 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 767468001617 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767468001618 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767468001619 ABC transporter; Region: ABC_tran_2; pfam12848 767468001620 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767468001621 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 767468001622 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 767468001623 CoA binding domain; Region: CoA_binding; pfam02629 767468001624 CAAX protease self-immunity; Region: Abi; pfam02517 767468001625 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 767468001626 oligomerisation interface [polypeptide binding]; other site 767468001627 mobile loop; other site 767468001628 roof hairpin; other site 767468001629 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 767468001630 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 767468001631 ring oligomerisation interface [polypeptide binding]; other site 767468001632 ATP/Mg binding site [chemical binding]; other site 767468001633 stacking interactions; other site 767468001634 hinge regions; other site 767468001635 Amino acid permease; Region: AA_permease_2; pfam13520 767468001636 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 767468001637 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 767468001638 Mg++ binding site [ion binding]; other site 767468001639 putative catalytic motif [active] 767468001640 substrate binding site [chemical binding]; other site 767468001641 PBP superfamily domain; Region: PBP_like_2; cl17296 767468001642 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 767468001643 Uncharacterized conserved protein [Function unknown]; Region: COG1739 767468001644 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 767468001645 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 767468001646 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 767468001647 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767468001648 ATP binding site [chemical binding]; other site 767468001649 putative Mg++ binding site [ion binding]; other site 767468001650 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767468001651 ATP-binding site [chemical binding]; other site 767468001652 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 767468001653 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767468001654 active site 767468001655 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 767468001656 30S subunit binding site; other site 767468001657 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 767468001658 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767468001659 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 767468001660 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767468001661 nucleotide binding region [chemical binding]; other site 767468001662 ATP-binding site [chemical binding]; other site 767468001663 peptide chain release factor 2; Validated; Region: prfB; PRK00578 767468001664 This domain is found in peptide chain release factors; Region: PCRF; smart00937 767468001665 RF-1 domain; Region: RF-1; pfam00472 767468001666 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 767468001667 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767468001668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767468001669 active site 767468001670 phosphorylation site [posttranslational modification] 767468001671 intermolecular recognition site; other site 767468001672 dimerization interface [polypeptide binding]; other site 767468001673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767468001674 DNA binding site [nucleotide binding] 767468001675 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 767468001676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767468001677 dimer interface [polypeptide binding]; other site 767468001678 phosphorylation site [posttranslational modification] 767468001679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767468001680 ATP binding site [chemical binding]; other site 767468001681 Mg2+ binding site [ion binding]; other site 767468001682 G-X-G motif; other site 767468001683 PBP superfamily domain; Region: PBP_like_2; cl17296 767468001684 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 767468001685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468001686 dimer interface [polypeptide binding]; other site 767468001687 conserved gate region; other site 767468001688 putative PBP binding loops; other site 767468001689 ABC-ATPase subunit interface; other site 767468001690 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 767468001691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468001692 putative PBP binding loops; other site 767468001693 ABC-ATPase subunit interface; other site 767468001694 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 767468001695 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 767468001696 Walker A/P-loop; other site 767468001697 ATP binding site [chemical binding]; other site 767468001698 Q-loop/lid; other site 767468001699 ABC transporter signature motif; other site 767468001700 Walker B; other site 767468001701 D-loop; other site 767468001702 H-loop/switch region; other site 767468001703 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 767468001704 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 767468001705 Walker A/P-loop; other site 767468001706 ATP binding site [chemical binding]; other site 767468001707 Q-loop/lid; other site 767468001708 ABC transporter signature motif; other site 767468001709 Walker B; other site 767468001710 D-loop; other site 767468001711 H-loop/switch region; other site 767468001712 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 767468001713 PhoU domain; Region: PhoU; pfam01895 767468001714 PhoU domain; Region: PhoU; pfam01895 767468001715 PspC domain; Region: PspC; pfam04024 767468001716 Predicted membrane protein [Function unknown]; Region: COG1950 767468001717 HPr kinase/phosphorylase; Provisional; Region: PRK05428 767468001718 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 767468001719 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 767468001720 Hpr binding site; other site 767468001721 active site 767468001722 homohexamer subunit interaction site [polypeptide binding]; other site 767468001723 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 767468001724 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 767468001725 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 767468001726 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 767468001727 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 767468001728 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 767468001729 active site 767468001730 tetramer interface; other site 767468001731 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 767468001732 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767468001733 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767468001734 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 767468001735 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767468001736 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767468001737 Predicted membrane protein [Function unknown]; Region: COG2323 767468001738 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 767468001739 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 767468001740 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 767468001741 active site 767468001742 substrate binding site [chemical binding]; other site 767468001743 metal binding site [ion binding]; metal-binding site 767468001744 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 767468001745 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 767468001746 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767468001747 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767468001748 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767468001749 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 767468001750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468001751 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468001752 putative substrate translocation pore; other site 767468001753 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767468001754 Zn2+ binding site [ion binding]; other site 767468001755 Mg2+ binding site [ion binding]; other site 767468001756 excinuclease ABC subunit B; Provisional; Region: PRK05298 767468001757 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767468001758 ATP binding site [chemical binding]; other site 767468001759 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767468001760 nucleotide binding region [chemical binding]; other site 767468001761 ATP-binding site [chemical binding]; other site 767468001762 Ultra-violet resistance protein B; Region: UvrB; pfam12344 767468001763 UvrB/uvrC motif; Region: UVR; pfam02151 767468001764 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 767468001765 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 767468001766 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 767468001767 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 767468001768 S-ribosylhomocysteinase; Provisional; Region: PRK02260 767468001769 argininosuccinate synthase; Provisional; Region: PRK13820 767468001770 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 767468001771 ANP binding site [chemical binding]; other site 767468001772 Substrate Binding Site II [chemical binding]; other site 767468001773 Substrate Binding Site I [chemical binding]; other site 767468001774 argininosuccinate lyase; Provisional; Region: PRK00855 767468001775 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 767468001776 active sites [active] 767468001777 tetramer interface [polypeptide binding]; other site 767468001778 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 767468001779 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 767468001780 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 767468001781 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 767468001782 phosphate binding site [ion binding]; other site 767468001783 putative substrate binding pocket [chemical binding]; other site 767468001784 dimer interface [polypeptide binding]; other site 767468001785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 767468001786 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 767468001787 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767468001788 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767468001789 peptide binding site [polypeptide binding]; other site 767468001790 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 767468001791 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 767468001792 putative ligand binding site [chemical binding]; other site 767468001793 putative NAD binding site [chemical binding]; other site 767468001794 catalytic site [active] 767468001795 Clp protease; Region: CLP_protease; pfam00574 767468001796 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 767468001797 oligomer interface [polypeptide binding]; other site 767468001798 active site residues [active] 767468001799 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 767468001800 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 767468001801 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 767468001802 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 767468001803 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 767468001804 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 767468001805 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 767468001806 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 767468001807 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 767468001808 Phosphoglycerate kinase; Region: PGK; pfam00162 767468001809 substrate binding site [chemical binding]; other site 767468001810 hinge regions; other site 767468001811 ADP binding site [chemical binding]; other site 767468001812 catalytic site [active] 767468001813 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 767468001814 triosephosphate isomerase; Provisional; Region: PRK14567 767468001815 substrate binding site [chemical binding]; other site 767468001816 dimer interface [polypeptide binding]; other site 767468001817 catalytic triad [active] 767468001818 enolase; Provisional; Region: eno; PRK00077 767468001819 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 767468001820 dimer interface [polypeptide binding]; other site 767468001821 metal binding site [ion binding]; metal-binding site 767468001822 substrate binding pocket [chemical binding]; other site 767468001823 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 767468001824 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 767468001825 Cl- selectivity filter; other site 767468001826 Cl- binding residues [ion binding]; other site 767468001827 pore gating glutamate residue; other site 767468001828 dimer interface [polypeptide binding]; other site 767468001829 H+/Cl- coupling transport residue; other site 767468001830 TrkA-C domain; Region: TrkA_C; pfam02080 767468001831 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 767468001832 Esterase/lipase [General function prediction only]; Region: COG1647 767468001833 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 767468001834 ribonuclease R; Region: RNase_R; TIGR02063 767468001835 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 767468001836 RNB domain; Region: RNB; pfam00773 767468001837 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 767468001838 RNA binding site [nucleotide binding]; other site 767468001839 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 767468001840 SmpB-tmRNA interface; other site 767468001841 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 767468001842 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 767468001843 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 767468001844 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 767468001845 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 767468001846 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767468001847 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767468001848 substrate binding pocket [chemical binding]; other site 767468001849 membrane-bound complex binding site; other site 767468001850 hinge residues; other site 767468001851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468001852 dimer interface [polypeptide binding]; other site 767468001853 conserved gate region; other site 767468001854 putative PBP binding loops; other site 767468001855 ABC-ATPase subunit interface; other site 767468001856 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767468001857 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767468001858 Walker A/P-loop; other site 767468001859 ATP binding site [chemical binding]; other site 767468001860 Q-loop/lid; other site 767468001861 ABC transporter signature motif; other site 767468001862 Walker B; other site 767468001863 D-loop; other site 767468001864 H-loop/switch region; other site 767468001865 Tubby C 2; Region: Tub_2; cl02043 767468001866 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468001867 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767468001868 active site 767468001869 motif I; other site 767468001870 motif II; other site 767468001871 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767468001872 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 767468001873 ligand binding site [chemical binding]; other site 767468001874 active site 767468001875 UGI interface [polypeptide binding]; other site 767468001876 catalytic site [active] 767468001877 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 767468001878 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 767468001879 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 767468001880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468001881 Coenzyme A binding pocket [chemical binding]; other site 767468001882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 767468001883 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 767468001884 active site 767468001885 catalytic site [active] 767468001886 substrate binding site [chemical binding]; other site 767468001887 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 767468001888 active site 767468001889 putative catalytic site [active] 767468001890 DNA binding site [nucleotide binding] 767468001891 putative phosphate binding site [ion binding]; other site 767468001892 metal binding site A [ion binding]; metal-binding site 767468001893 AP binding site [nucleotide binding]; other site 767468001894 metal binding site B [ion binding]; metal-binding site 767468001895 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 767468001896 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767468001897 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 767468001898 FAD binding domain; Region: FAD_binding_4; pfam01565 767468001899 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 767468001900 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 767468001901 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 767468001902 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 767468001903 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 767468001904 Uncharacterized conserved protein [Function unknown]; Region: COG1624 767468001905 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 767468001906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 767468001907 YbbR-like protein; Region: YbbR; pfam07949 767468001908 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 767468001909 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 767468001910 active site 767468001911 substrate binding site [chemical binding]; other site 767468001912 metal binding site [ion binding]; metal-binding site 767468001913 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 767468001914 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 767468001915 glutaminase active site [active] 767468001916 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 767468001917 dimer interface [polypeptide binding]; other site 767468001918 active site 767468001919 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 767468001920 dimer interface [polypeptide binding]; other site 767468001921 active site 767468001922 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468001923 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468001924 Integrase core domain; Region: rve; pfam00665 767468001925 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 767468001926 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 767468001927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468001928 active site 767468001929 motif I; other site 767468001930 motif II; other site 767468001931 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767468001932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468001933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767468001934 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 767468001935 active site 767468001936 catalytic residues [active] 767468001937 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 767468001938 dimer interface [polypeptide binding]; other site 767468001939 FMN binding site [chemical binding]; other site 767468001940 NADPH bind site [chemical binding]; other site 767468001941 H+ Antiporter protein; Region: 2A0121; TIGR00900 767468001942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468001943 putative substrate translocation pore; other site 767468001944 glycerol kinase; Provisional; Region: glpK; PRK00047 767468001945 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 767468001946 N- and C-terminal domain interface [polypeptide binding]; other site 767468001947 active site 767468001948 MgATP binding site [chemical binding]; other site 767468001949 catalytic site [active] 767468001950 metal binding site [ion binding]; metal-binding site 767468001951 glycerol binding site [chemical binding]; other site 767468001952 homotetramer interface [polypeptide binding]; other site 767468001953 homodimer interface [polypeptide binding]; other site 767468001954 FBP binding site [chemical binding]; other site 767468001955 protein IIAGlc interface [polypeptide binding]; other site 767468001956 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 767468001957 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 767468001958 putative catalytic residues [active] 767468001959 thiol/disulfide switch; other site 767468001960 ArsC family; Region: ArsC; pfam03960 767468001961 VanZ like family; Region: VanZ; cl01971 767468001962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468001963 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468001964 putative substrate translocation pore; other site 767468001965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468001966 exopolyphosphatase; Region: exo_poly_only; TIGR03706 767468001967 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 767468001968 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 767468001969 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 767468001970 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 767468001971 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 767468001972 putative domain interface [polypeptide binding]; other site 767468001973 putative active site [active] 767468001974 catalytic site [active] 767468001975 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 767468001976 putative domain interface [polypeptide binding]; other site 767468001977 putative active site [active] 767468001978 catalytic site [active] 767468001979 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 767468001980 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767468001981 Zn2+ binding site [ion binding]; other site 767468001982 Mg2+ binding site [ion binding]; other site 767468001983 LicD family; Region: LicD; pfam04991 767468001984 Transcriptional regulators [Transcription]; Region: MarR; COG1846 767468001985 MarR family; Region: MarR_2; pfam12802 767468001986 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 767468001987 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 767468001988 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 767468001989 PYR/PP interface [polypeptide binding]; other site 767468001990 dimer interface [polypeptide binding]; other site 767468001991 tetramer interface [polypeptide binding]; other site 767468001992 TPP binding site [chemical binding]; other site 767468001993 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 767468001994 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 767468001995 TPP-binding site [chemical binding]; other site 767468001996 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 767468001997 active site 767468001998 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 767468001999 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 767468002000 PYR/PP interface [polypeptide binding]; other site 767468002001 dimer interface [polypeptide binding]; other site 767468002002 tetramer interface [polypeptide binding]; other site 767468002003 TPP binding site [chemical binding]; other site 767468002004 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 767468002005 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 767468002006 TPP-binding site [chemical binding]; other site 767468002007 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 767468002008 recA bacterial DNA recombination protein; Region: RecA; cl17211 767468002009 TAP-like protein; Region: Abhydrolase_4; pfam08386 767468002010 Biotin operon repressor [Transcription]; Region: BirA; COG1654 767468002011 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 767468002012 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 767468002013 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 767468002014 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 767468002015 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 767468002016 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 767468002017 catalytic triad [active] 767468002018 catalytic triad [active] 767468002019 oxyanion hole [active] 767468002020 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 767468002021 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 767468002022 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 767468002023 OsmC-like protein; Region: OsmC; cl00767 767468002024 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 767468002025 amino acid transporter; Region: 2A0306; TIGR00909 767468002026 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 767468002027 AP2 domain; Region: AP2; pfam00847 767468002028 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 767468002029 substrate binding site [chemical binding]; other site 767468002030 ATP binding site [chemical binding]; other site 767468002031 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 767468002032 active site 767468002033 Ap4A binding cleft/pocket [chemical binding]; other site 767468002034 P4 phosphate binding site; other site 767468002035 nudix motif; other site 767468002036 putative P2/P3 phosphate binding site [ion binding]; other site 767468002037 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 767468002038 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 767468002039 catalytic site [active] 767468002040 G-X2-G-X-G-K; other site 767468002041 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 767468002042 metal binding site 2 [ion binding]; metal-binding site 767468002043 putative DNA binding helix; other site 767468002044 metal binding site 1 [ion binding]; metal-binding site 767468002045 dimer interface [polypeptide binding]; other site 767468002046 structural Zn2+ binding site [ion binding]; other site 767468002047 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 767468002048 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767468002049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468002050 homodimer interface [polypeptide binding]; other site 767468002051 catalytic residue [active] 767468002052 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 767468002053 D-lactate dehydrogenase; Validated; Region: PRK08605 767468002054 homodimer interface [polypeptide binding]; other site 767468002055 ligand binding site [chemical binding]; other site 767468002056 NAD binding site [chemical binding]; other site 767468002057 catalytic site [active] 767468002058 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767468002059 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767468002060 Walker A/P-loop; other site 767468002061 ATP binding site [chemical binding]; other site 767468002062 Q-loop/lid; other site 767468002063 ABC transporter signature motif; other site 767468002064 Walker B; other site 767468002065 D-loop; other site 767468002066 H-loop/switch region; other site 767468002067 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767468002068 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767468002069 substrate binding pocket [chemical binding]; other site 767468002070 membrane-bound complex binding site; other site 767468002071 hinge residues; other site 767468002072 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 767468002073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468002074 dimer interface [polypeptide binding]; other site 767468002075 conserved gate region; other site 767468002076 putative PBP binding loops; other site 767468002077 ABC-ATPase subunit interface; other site 767468002078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468002079 dimer interface [polypeptide binding]; other site 767468002080 conserved gate region; other site 767468002081 putative PBP binding loops; other site 767468002082 ABC-ATPase subunit interface; other site 767468002083 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 767468002084 HPr interaction site; other site 767468002085 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767468002086 active site 767468002087 phosphorylation site [posttranslational modification] 767468002088 CAT RNA binding domain; Region: CAT_RBD; smart01061 767468002089 transcriptional antiterminator BglG; Provisional; Region: PRK09772 767468002090 PRD domain; Region: PRD; pfam00874 767468002091 PRD domain; Region: PRD; pfam00874 767468002092 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 767468002093 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767468002094 active site turn [active] 767468002095 phosphorylation site [posttranslational modification] 767468002096 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767468002097 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 767468002098 putative active site [active] 767468002099 YdjC motif; other site 767468002100 Mg binding site [ion binding]; other site 767468002101 putative homodimer interface [polypeptide binding]; other site 767468002102 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 767468002103 Transcriptional regulators [Transcription]; Region: MarR; COG1846 767468002104 MarR family; Region: MarR; pfam01047 767468002105 Transcriptional regulators [Transcription]; Region: MarR; COG1846 767468002106 MarR family; Region: MarR_2; pfam12802 767468002107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468002108 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468002109 putative substrate translocation pore; other site 767468002110 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 767468002111 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468002112 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767468002113 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 767468002114 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 767468002115 HflX GTPase family; Region: HflX; cd01878 767468002116 G1 box; other site 767468002117 GTP/Mg2+ binding site [chemical binding]; other site 767468002118 Switch I region; other site 767468002119 G2 box; other site 767468002120 G3 box; other site 767468002121 Switch II region; other site 767468002122 G4 box; other site 767468002123 G5 box; other site 767468002124 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 767468002125 nudix motif; other site 767468002126 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 767468002127 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767468002128 catalytic core [active] 767468002129 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767468002130 catalytic core [active] 767468002131 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 767468002132 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 767468002133 TrkA-N domain; Region: TrkA_N; pfam02254 767468002134 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 767468002135 TrkA-C domain; Region: TrkA_C; pfam02080 767468002136 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 767468002137 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 767468002138 putative active site [active] 767468002139 nucleotide binding site [chemical binding]; other site 767468002140 nudix motif; other site 767468002141 putative metal binding site [ion binding]; other site 767468002142 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 767468002143 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 767468002144 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 767468002145 Part of AAA domain; Region: AAA_19; pfam13245 767468002146 Family description; Region: UvrD_C_2; pfam13538 767468002147 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 767468002148 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 767468002149 FMN binding site [chemical binding]; other site 767468002150 substrate binding site [chemical binding]; other site 767468002151 putative catalytic residue [active] 767468002152 pantothenate kinase; Provisional; Region: PRK05439 767468002153 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 767468002154 ATP-binding site [chemical binding]; other site 767468002155 CoA-binding site [chemical binding]; other site 767468002156 Mg2+-binding site [ion binding]; other site 767468002157 GMP synthase; Reviewed; Region: guaA; PRK00074 767468002158 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 767468002159 AMP/PPi binding site [chemical binding]; other site 767468002160 candidate oxyanion hole; other site 767468002161 catalytic triad [active] 767468002162 potential glutamine specificity residues [chemical binding]; other site 767468002163 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 767468002164 ATP Binding subdomain [chemical binding]; other site 767468002165 Dimerization subdomain; other site 767468002166 stage V sporulation protein K; Region: spore_V_K; TIGR02881 767468002167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468002168 Walker A motif; other site 767468002169 ATP binding site [chemical binding]; other site 767468002170 Walker B motif; other site 767468002171 arginine finger; other site 767468002172 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468002173 putative transposase OrfB; Reviewed; Region: PHA02517 767468002174 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767468002175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468002176 non-specific DNA binding site [nucleotide binding]; other site 767468002177 salt bridge; other site 767468002178 sequence-specific DNA binding site [nucleotide binding]; other site 767468002179 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767468002180 MULE transposase domain; Region: MULE; pfam10551 767468002181 CAAX protease self-immunity; Region: Abi; pfam02517 767468002182 Predicted transcriptional regulators [Transcription]; Region: COG1733 767468002183 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 767468002184 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468002185 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767468002186 Transposase; Region: HTH_Tnp_1; cl17663 767468002187 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468002188 putative transposase OrfB; Reviewed; Region: PHA02517 767468002189 HTH-like domain; Region: HTH_21; pfam13276 767468002190 Integrase core domain; Region: rve; pfam00665 767468002191 Integrase core domain; Region: rve_3; pfam13683 767468002192 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 767468002193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468002194 putative substrate translocation pore; other site 767468002195 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 767468002196 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468002197 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468002198 Integrase core domain; Region: rve; pfam00665 767468002199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 767468002200 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 767468002201 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 767468002202 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 767468002203 catalytic triad [active] 767468002204 catalytic triad [active] 767468002205 oxyanion hole [active] 767468002206 Predicted membrane protein [Function unknown]; Region: COG2261 767468002207 Asp23 family; Region: Asp23; pfam03780 767468002208 Asp23 family; Region: Asp23; pfam03780 767468002209 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 767468002210 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 767468002211 Peptidase family M1; Region: Peptidase_M1; pfam01433 767468002212 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 767468002213 Zn binding site [ion binding]; other site 767468002214 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 767468002215 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 767468002216 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 767468002217 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468002218 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468002219 Integrase core domain; Region: rve; pfam00665 767468002220 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 767468002221 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767468002222 ATP binding site [chemical binding]; other site 767468002223 putative Mg++ binding site [ion binding]; other site 767468002224 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 767468002225 HsdM N-terminal domain; Region: HsdM_N; pfam12161 767468002226 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 767468002227 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 767468002228 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 767468002229 Int/Topo IB signature motif; other site 767468002230 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 767468002231 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767468002232 catalytic core [active] 767468002233 hypothetical protein; Provisional; Region: PRK06762 767468002234 AAA domain; Region: AAA_33; pfam13671 767468002235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468002236 non-specific DNA binding site [nucleotide binding]; other site 767468002237 salt bridge; other site 767468002238 sequence-specific DNA binding site [nucleotide binding]; other site 767468002239 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767468002240 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468002241 non-specific DNA binding site [nucleotide binding]; other site 767468002242 salt bridge; other site 767468002243 sequence-specific DNA binding site [nucleotide binding]; other site 767468002244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468002245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767468002246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767468002247 dimerization interface [polypeptide binding]; other site 767468002248 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767468002249 MarR family; Region: MarR_2; cl17246 767468002250 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 767468002251 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 767468002252 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 767468002253 putative dimer interface [polypeptide binding]; other site 767468002254 putative anticodon binding site; other site 767468002255 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 767468002256 homodimer interface [polypeptide binding]; other site 767468002257 motif 1; other site 767468002258 motif 2; other site 767468002259 active site 767468002260 motif 3; other site 767468002261 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 767468002262 dimer interface [polypeptide binding]; other site 767468002263 active site 767468002264 Peptidase family C69; Region: Peptidase_C69; pfam03577 767468002265 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468002266 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 767468002267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767468002268 ATP binding site [chemical binding]; other site 767468002269 putative Mg++ binding site [ion binding]; other site 767468002270 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767468002271 nucleotide binding region [chemical binding]; other site 767468002272 ATP-binding site [chemical binding]; other site 767468002273 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 767468002274 HRDC domain; Region: HRDC; pfam00570 767468002275 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767468002276 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767468002277 active site 767468002278 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767468002279 dimerization interface [polypeptide binding]; other site 767468002280 putative DNA binding site [nucleotide binding]; other site 767468002281 putative Zn2+ binding site [ion binding]; other site 767468002282 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 767468002283 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767468002284 YibE/F-like protein; Region: YibE_F; pfam07907 767468002285 YibE/F-like protein; Region: YibE_F; pfam07907 767468002286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468002287 Coenzyme A binding pocket [chemical binding]; other site 767468002288 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767468002289 catalytic core [active] 767468002290 Enterocin A Immunity; Region: EntA_Immun; pfam08951 767468002291 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 767468002292 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 767468002293 MFS/sugar transport protein; Region: MFS_2; pfam13347 767468002294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468002295 putative substrate translocation pore; other site 767468002296 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 767468002297 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767468002298 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767468002299 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767468002300 aspartate kinase I; Reviewed; Region: PRK08210 767468002301 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 767468002302 putative catalytic residues [active] 767468002303 putative nucleotide binding site [chemical binding]; other site 767468002304 putative aspartate binding site [chemical binding]; other site 767468002305 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 767468002306 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 767468002307 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 767468002308 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 767468002309 active site 767468002310 dimer interface [polypeptide binding]; other site 767468002311 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 767468002312 Ligand Binding Site [chemical binding]; other site 767468002313 Molecular Tunnel; other site 767468002314 Predicted membrane protein [Function unknown]; Region: COG4392 767468002315 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 767468002316 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 767468002317 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 767468002318 DNA binding residues [nucleotide binding] 767468002319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468002320 putative substrate translocation pore; other site 767468002321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468002322 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 767468002323 DNA binding residues [nucleotide binding] 767468002324 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 767468002325 putative dimer interface [polypeptide binding]; other site 767468002326 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 767468002327 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 767468002328 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 767468002329 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 767468002330 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 767468002331 DNA-binding site [nucleotide binding]; DNA binding site 767468002332 RNA-binding motif; other site 767468002333 Uncharacterized conserved protein [Function unknown]; Region: COG2966 767468002334 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 767468002335 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 767468002336 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 767468002337 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 767468002338 active site 767468002339 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 767468002340 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 767468002341 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 767468002342 Predicted transcriptional regulator [Transcription]; Region: COG1959 767468002343 Transcriptional regulator; Region: Rrf2; pfam02082 767468002344 acetolactate synthase; Reviewed; Region: PRK08617 767468002345 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 767468002346 PYR/PP interface [polypeptide binding]; other site 767468002347 dimer interface [polypeptide binding]; other site 767468002348 TPP binding site [chemical binding]; other site 767468002349 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 767468002350 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 767468002351 TPP-binding site [chemical binding]; other site 767468002352 dimer interface [polypeptide binding]; other site 767468002353 lysine transporter; Provisional; Region: PRK10836 767468002354 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 767468002355 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 767468002356 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 767468002357 Substrate-binding site [chemical binding]; other site 767468002358 Substrate specificity [chemical binding]; other site 767468002359 seryl-tRNA synthetase; Provisional; Region: PRK05431 767468002360 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 767468002361 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 767468002362 dimer interface [polypeptide binding]; other site 767468002363 active site 767468002364 motif 1; other site 767468002365 motif 2; other site 767468002366 motif 3; other site 767468002367 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 767468002368 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 767468002369 Clp amino terminal domain; Region: Clp_N; pfam02861 767468002370 Clp amino terminal domain; Region: Clp_N; pfam02861 767468002371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468002372 Walker A motif; other site 767468002373 ATP binding site [chemical binding]; other site 767468002374 Walker B motif; other site 767468002375 arginine finger; other site 767468002376 UvrB/uvrC motif; Region: UVR; pfam02151 767468002377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468002378 Walker A motif; other site 767468002379 ATP binding site [chemical binding]; other site 767468002380 Walker B motif; other site 767468002381 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 767468002382 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468002383 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767468002384 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 767468002385 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 767468002386 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 767468002387 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 767468002388 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 767468002389 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 767468002390 RPB1 interaction site [polypeptide binding]; other site 767468002391 RPB10 interaction site [polypeptide binding]; other site 767468002392 RPB11 interaction site [polypeptide binding]; other site 767468002393 RPB3 interaction site [polypeptide binding]; other site 767468002394 RPB12 interaction site [polypeptide binding]; other site 767468002395 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 767468002396 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 767468002397 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 767468002398 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 767468002399 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 767468002400 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 767468002401 cleft; other site 767468002402 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 767468002403 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 767468002404 DNA binding site [nucleotide binding] 767468002405 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 767468002406 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 767468002407 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 767468002408 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 767468002409 S17 interaction site [polypeptide binding]; other site 767468002410 S8 interaction site; other site 767468002411 16S rRNA interaction site [nucleotide binding]; other site 767468002412 streptomycin interaction site [chemical binding]; other site 767468002413 23S rRNA interaction site [nucleotide binding]; other site 767468002414 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 767468002415 30S ribosomal protein S7; Validated; Region: PRK05302 767468002416 elongation factor G; Reviewed; Region: PRK12739 767468002417 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 767468002418 G1 box; other site 767468002419 putative GEF interaction site [polypeptide binding]; other site 767468002420 GTP/Mg2+ binding site [chemical binding]; other site 767468002421 Switch I region; other site 767468002422 G2 box; other site 767468002423 G3 box; other site 767468002424 Switch II region; other site 767468002425 G4 box; other site 767468002426 G5 box; other site 767468002427 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 767468002428 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 767468002429 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 767468002430 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 767468002431 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 767468002432 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 767468002433 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 767468002434 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 767468002435 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 767468002436 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 767468002437 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 767468002438 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 767468002439 putative translocon binding site; other site 767468002440 protein-rRNA interface [nucleotide binding]; other site 767468002441 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 767468002442 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 767468002443 G-X-X-G motif; other site 767468002444 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 767468002445 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 767468002446 23S rRNA interface [nucleotide binding]; other site 767468002447 5S rRNA interface [nucleotide binding]; other site 767468002448 putative antibiotic binding site [chemical binding]; other site 767468002449 L25 interface [polypeptide binding]; other site 767468002450 L27 interface [polypeptide binding]; other site 767468002451 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 767468002452 23S rRNA interface [nucleotide binding]; other site 767468002453 putative translocon interaction site; other site 767468002454 signal recognition particle (SRP54) interaction site; other site 767468002455 L23 interface [polypeptide binding]; other site 767468002456 trigger factor interaction site; other site 767468002457 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 767468002458 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 767468002459 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 767468002460 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 767468002461 RNA binding site [nucleotide binding]; other site 767468002462 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 767468002463 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 767468002464 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 767468002465 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 767468002466 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 767468002467 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 767468002468 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 767468002469 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 767468002470 5S rRNA interface [nucleotide binding]; other site 767468002471 L27 interface [polypeptide binding]; other site 767468002472 23S rRNA interface [nucleotide binding]; other site 767468002473 L5 interface [polypeptide binding]; other site 767468002474 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 767468002475 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 767468002476 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 767468002477 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 767468002478 23S rRNA binding site [nucleotide binding]; other site 767468002479 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 767468002480 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 767468002481 SecY translocase; Region: SecY; pfam00344 767468002482 adenylate kinase; Reviewed; Region: adk; PRK00279 767468002483 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 767468002484 AMP-binding site [chemical binding]; other site 767468002485 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 767468002486 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 767468002487 rRNA binding site [nucleotide binding]; other site 767468002488 predicted 30S ribosome binding site; other site 767468002489 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 767468002490 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 767468002491 30S ribosomal protein S13; Region: bact_S13; TIGR03631 767468002492 30S ribosomal protein S11; Validated; Region: PRK05309 767468002493 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 767468002494 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 767468002495 alphaNTD homodimer interface [polypeptide binding]; other site 767468002496 alphaNTD - beta interaction site [polypeptide binding]; other site 767468002497 alphaNTD - beta' interaction site [polypeptide binding]; other site 767468002498 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 767468002499 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 767468002500 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 767468002501 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 767468002502 substrate binding pocket [chemical binding]; other site 767468002503 chain length determination region; other site 767468002504 substrate-Mg2+ binding site; other site 767468002505 catalytic residues [active] 767468002506 aspartate-rich region 1; other site 767468002507 active site lid residues [active] 767468002508 aspartate-rich region 2; other site 767468002509 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 767468002510 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 767468002511 trimer interface [polypeptide binding]; other site 767468002512 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 767468002513 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767468002514 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 767468002515 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 767468002516 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 767468002517 ApbE family; Region: ApbE; pfam02424 767468002518 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 767468002519 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767468002520 Walker A/P-loop; other site 767468002521 ATP binding site [chemical binding]; other site 767468002522 Q-loop/lid; other site 767468002523 ABC transporter signature motif; other site 767468002524 Walker B; other site 767468002525 D-loop; other site 767468002526 H-loop/switch region; other site 767468002527 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 767468002528 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767468002529 Walker A/P-loop; other site 767468002530 ATP binding site [chemical binding]; other site 767468002531 Q-loop/lid; other site 767468002532 ABC transporter signature motif; other site 767468002533 Walker B; other site 767468002534 D-loop; other site 767468002535 H-loop/switch region; other site 767468002536 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 767468002537 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 767468002538 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 767468002539 dimerization interface 3.5A [polypeptide binding]; other site 767468002540 active site 767468002541 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 767468002542 23S rRNA interface [nucleotide binding]; other site 767468002543 L3 interface [polypeptide binding]; other site 767468002544 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 767468002545 EDD domain protein, DegV family; Region: DegV; TIGR00762 767468002546 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767468002547 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 767468002548 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 767468002549 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 767468002550 TPP-binding site [chemical binding]; other site 767468002551 dimer interface [polypeptide binding]; other site 767468002552 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 767468002553 PYR/PP interface [polypeptide binding]; other site 767468002554 dimer interface [polypeptide binding]; other site 767468002555 TPP binding site [chemical binding]; other site 767468002556 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 767468002557 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 767468002558 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 767468002559 shikimate binding site; other site 767468002560 NAD(P) binding site [chemical binding]; other site 767468002561 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 767468002562 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 767468002563 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 767468002564 active site 767468002565 dimer interface [polypeptide binding]; other site 767468002566 metal binding site [ion binding]; metal-binding site 767468002567 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 767468002568 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 767468002569 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 767468002570 Cupin domain; Region: Cupin_2; pfam07883 767468002571 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 767468002572 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 767468002573 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 767468002574 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 767468002575 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 767468002576 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 767468002577 ABC-ATPase subunit interface; other site 767468002578 dimer interface [polypeptide binding]; other site 767468002579 putative PBP binding regions; other site 767468002580 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 767468002581 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 767468002582 metal binding site [ion binding]; metal-binding site 767468002583 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 767468002584 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 767468002585 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767468002586 NAD binding site [chemical binding]; other site 767468002587 dimer interface [polypeptide binding]; other site 767468002588 substrate binding site [chemical binding]; other site 767468002589 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 767468002590 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 767468002591 transmembrane helices; other site 767468002592 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 767468002593 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 767468002594 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 767468002595 Malic enzyme, N-terminal domain; Region: malic; pfam00390 767468002596 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 767468002597 NAD(P) binding pocket [chemical binding]; other site 767468002598 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 767468002599 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 767468002600 putative active site [active] 767468002601 (T/H)XGH motif; other site 767468002602 citrate lyase subunit gamma; Provisional; Region: PRK13253 767468002603 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 767468002604 citrate lyase, alpha subunit; Region: citF; TIGR01584 767468002605 fumarate hydratase; Reviewed; Region: fumC; PRK00485 767468002606 Class II fumarases; Region: Fumarase_classII; cd01362 767468002607 active site 767468002608 tetramer interface [polypeptide binding]; other site 767468002609 L-aspartate oxidase; Provisional; Region: PRK06175 767468002610 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 767468002611 L-aspartate oxidase; Provisional; Region: PRK06175 767468002612 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 767468002613 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468002614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767468002615 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 767468002616 dimerization interface [polypeptide binding]; other site 767468002617 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468002618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767468002619 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 767468002620 dimerization interface [polypeptide binding]; other site 767468002621 malate dehydrogenase; Provisional; Region: PRK13529 767468002622 Malic enzyme, N-terminal domain; Region: malic; pfam00390 767468002623 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 767468002624 NAD(P) binding site [chemical binding]; other site 767468002625 Membrane transport protein; Region: Mem_trans; cl09117 767468002626 amino acid transporter; Region: 2A0306; TIGR00909 767468002627 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 767468002628 Predicted membrane protein [Function unknown]; Region: COG4684 767468002629 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 767468002630 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 767468002631 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 767468002632 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 767468002633 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 767468002634 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 767468002635 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 767468002636 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767468002637 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 767468002638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468002639 Walker A/P-loop; other site 767468002640 ATP binding site [chemical binding]; other site 767468002641 Q-loop/lid; other site 767468002642 ABC transporter signature motif; other site 767468002643 Walker B; other site 767468002644 D-loop; other site 767468002645 H-loop/switch region; other site 767468002646 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 767468002647 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767468002648 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 767468002649 Walker A/P-loop; other site 767468002650 ATP binding site [chemical binding]; other site 767468002651 Q-loop/lid; other site 767468002652 ABC transporter signature motif; other site 767468002653 Walker B; other site 767468002654 D-loop; other site 767468002655 H-loop/switch region; other site 767468002656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 767468002657 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 767468002658 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 767468002659 substrate binding pocket [chemical binding]; other site 767468002660 chain length determination region; other site 767468002661 substrate-Mg2+ binding site; other site 767468002662 catalytic residues [active] 767468002663 aspartate-rich region 1; other site 767468002664 active site lid residues [active] 767468002665 aspartate-rich region 2; other site 767468002666 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 767468002667 UbiA prenyltransferase family; Region: UbiA; pfam01040 767468002668 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468002669 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468002670 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 767468002671 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 767468002672 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767468002673 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 767468002674 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767468002675 active site 767468002676 hypothetical protein; Provisional; Region: PRK04164 767468002677 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 767468002678 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767468002679 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 767468002680 Part of AAA domain; Region: AAA_19; pfam13245 767468002681 Family description; Region: UvrD_C_2; pfam13538 767468002682 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 767468002683 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 767468002684 nucleotide binding pocket [chemical binding]; other site 767468002685 K-X-D-G motif; other site 767468002686 catalytic site [active] 767468002687 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 767468002688 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 767468002689 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 767468002690 Dimer interface [polypeptide binding]; other site 767468002691 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 767468002692 putative dimer interface [polypeptide binding]; other site 767468002693 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 767468002694 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 767468002695 putative dimer interface [polypeptide binding]; other site 767468002696 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 767468002697 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 767468002698 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 767468002699 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 767468002700 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 767468002701 GatB domain; Region: GatB_Yqey; pfam02637 767468002702 putative lipid kinase; Reviewed; Region: PRK13055 767468002703 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 767468002704 TRAM domain; Region: TRAM; pfam01938 767468002705 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 767468002706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767468002707 S-adenosylmethionine binding site [chemical binding]; other site 767468002708 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468002709 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767468002710 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 767468002711 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767468002712 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767468002713 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 767468002714 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767468002715 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 767468002716 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 767468002717 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 767468002718 putative active site [active] 767468002719 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 767468002720 active site 767468002721 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 767468002722 DNA-binding site [nucleotide binding]; DNA binding site 767468002723 RNA-binding motif; other site 767468002724 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 767468002725 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767468002726 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767468002727 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767468002728 ATP binding site [chemical binding]; other site 767468002729 putative Mg++ binding site [ion binding]; other site 767468002730 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767468002731 nucleotide binding region [chemical binding]; other site 767468002732 ATP-binding site [chemical binding]; other site 767468002733 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767468002734 Ligand Binding Site [chemical binding]; other site 767468002735 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 767468002736 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 767468002737 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767468002738 glutamate dehydrogenase; Provisional; Region: PRK09414 767468002739 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 767468002740 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 767468002741 NAD(P) binding site [chemical binding]; other site 767468002742 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767468002743 Beta-lactamase; Region: Beta-lactamase; pfam00144 767468002744 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 767468002745 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 767468002746 active site 767468002747 homodimer interface [polypeptide binding]; other site 767468002748 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 767468002749 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 767468002750 amphipathic channel; other site 767468002751 Asn-Pro-Ala signature motifs; other site 767468002752 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767468002753 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 767468002754 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767468002755 recombination regulator RecX; Provisional; Region: recX; PRK14135 767468002756 hypothetical protein; Provisional; Region: PRK13662 767468002757 NlpC/P60 family; Region: NLPC_P60; pfam00877 767468002758 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767468002759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468002760 non-specific DNA binding site [nucleotide binding]; other site 767468002761 salt bridge; other site 767468002762 sequence-specific DNA binding site [nucleotide binding]; other site 767468002763 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 767468002764 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 767468002765 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767468002766 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 767468002767 NAD binding site [chemical binding]; other site 767468002768 dimer interface [polypeptide binding]; other site 767468002769 substrate binding site [chemical binding]; other site 767468002770 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 767468002771 Domain of unknown function DUF20; Region: UPF0118; pfam01594 767468002772 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767468002773 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 767468002774 active site 767468002775 nucleotide binding site [chemical binding]; other site 767468002776 HIGH motif; other site 767468002777 KMSKS motif; other site 767468002778 fructuronate transporter; Provisional; Region: PRK10034; cl15264 767468002779 GntP family permease; Region: GntP_permease; pfam02447 767468002780 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 767468002781 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 767468002782 N- and C-terminal domain interface [polypeptide binding]; other site 767468002783 active site 767468002784 catalytic site [active] 767468002785 metal binding site [ion binding]; metal-binding site 767468002786 carbohydrate binding site [chemical binding]; other site 767468002787 ATP binding site [chemical binding]; other site 767468002788 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 767468002789 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 767468002790 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 767468002791 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767468002792 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767468002793 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 767468002794 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 767468002795 G1 box; other site 767468002796 putative GEF interaction site [polypeptide binding]; other site 767468002797 GTP/Mg2+ binding site [chemical binding]; other site 767468002798 Switch I region; other site 767468002799 G2 box; other site 767468002800 G3 box; other site 767468002801 Switch II region; other site 767468002802 G4 box; other site 767468002803 G5 box; other site 767468002804 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 767468002805 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 767468002806 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 767468002807 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468002808 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767468002809 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767468002810 dimerization interface [polypeptide binding]; other site 767468002811 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 767468002812 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 767468002813 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767468002814 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767468002815 peptide binding site [polypeptide binding]; other site 767468002816 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 767468002817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468002818 dimer interface [polypeptide binding]; other site 767468002819 conserved gate region; other site 767468002820 putative PBP binding loops; other site 767468002821 ABC-ATPase subunit interface; other site 767468002822 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 767468002823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468002824 dimer interface [polypeptide binding]; other site 767468002825 conserved gate region; other site 767468002826 putative PBP binding loops; other site 767468002827 ABC-ATPase subunit interface; other site 767468002828 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 767468002829 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 767468002830 Walker A/P-loop; other site 767468002831 ATP binding site [chemical binding]; other site 767468002832 Q-loop/lid; other site 767468002833 ABC transporter signature motif; other site 767468002834 Walker B; other site 767468002835 D-loop; other site 767468002836 H-loop/switch region; other site 767468002837 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 767468002838 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 767468002839 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 767468002840 Walker A/P-loop; other site 767468002841 ATP binding site [chemical binding]; other site 767468002842 Q-loop/lid; other site 767468002843 ABC transporter signature motif; other site 767468002844 Walker B; other site 767468002845 D-loop; other site 767468002846 H-loop/switch region; other site 767468002847 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 767468002848 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767468002849 MarR family; Region: MarR_2; pfam12802 767468002850 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767468002851 active site 767468002852 Int/Topo IB signature motif; other site 767468002853 DNA binding site [nucleotide binding] 767468002854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468002855 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767468002856 Walker A motif; other site 767468002857 ATP binding site [chemical binding]; other site 767468002858 Walker B motif; other site 767468002859 arginine finger; other site 767468002860 UvrB/uvrC motif; Region: UVR; pfam02151 767468002861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468002862 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767468002863 Walker A motif; other site 767468002864 ATP binding site [chemical binding]; other site 767468002865 Walker B motif; other site 767468002866 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 767468002867 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 767468002868 dimerization domain swap beta strand [polypeptide binding]; other site 767468002869 regulatory protein interface [polypeptide binding]; other site 767468002870 active site 767468002871 regulatory phosphorylation site [posttranslational modification]; other site 767468002872 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 767468002873 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 767468002874 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 767468002875 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 767468002876 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767468002877 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 767468002878 putative ADP-binding pocket [chemical binding]; other site 767468002879 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 767468002880 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767468002881 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 767468002882 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 767468002883 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 767468002884 aromatic amino acid aminotransferase; Validated; Region: PRK07309 767468002885 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767468002886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468002887 homodimer interface [polypeptide binding]; other site 767468002888 catalytic residue [active] 767468002889 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 767468002890 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 767468002891 Sulfatase; Region: Sulfatase; pfam00884 767468002892 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767468002893 active site 767468002894 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 767468002895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468002896 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 767468002897 Coenzyme A binding pocket [chemical binding]; other site 767468002898 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 767468002899 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 767468002900 Ferrochelatase; Region: Ferrochelatase; pfam00762 767468002901 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 767468002902 C-terminal domain interface [polypeptide binding]; other site 767468002903 active site 767468002904 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 767468002905 active site 767468002906 N-terminal domain interface [polypeptide binding]; other site 767468002907 S-methylmethionine transporter; Provisional; Region: PRK11387 767468002908 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 767468002909 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 767468002910 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 767468002911 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 767468002912 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 767468002913 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767468002914 S-adenosylmethionine synthetase; Validated; Region: PRK05250 767468002915 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 767468002916 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 767468002917 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 767468002918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468002919 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468002920 putative substrate translocation pore; other site 767468002921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468002922 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 767468002923 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 767468002924 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767468002925 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 767468002926 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 767468002927 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767468002928 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 767468002929 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 767468002930 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 767468002931 active site 767468002932 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 767468002933 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 767468002934 HIGH motif; other site 767468002935 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 767468002936 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 767468002937 active site 767468002938 KMSKS motif; other site 767468002939 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 767468002940 tRNA binding surface [nucleotide binding]; other site 767468002941 stage V sporulation protein B; Region: spore_V_B; TIGR02900 767468002942 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 767468002943 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 767468002944 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767468002945 RNA binding surface [nucleotide binding]; other site 767468002946 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 767468002947 active site 767468002948 uracil binding [chemical binding]; other site 767468002949 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 767468002950 putative substrate binding site [chemical binding]; other site 767468002951 putative ATP binding site [chemical binding]; other site 767468002952 dipeptidase PepV; Reviewed; Region: PRK07318 767468002953 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 767468002954 active site 767468002955 metal binding site [ion binding]; metal-binding site 767468002956 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767468002957 Ligand Binding Site [chemical binding]; other site 767468002958 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 767468002959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468002960 Walker A/P-loop; other site 767468002961 ATP binding site [chemical binding]; other site 767468002962 Q-loop/lid; other site 767468002963 ABC transporter signature motif; other site 767468002964 Walker B; other site 767468002965 D-loop; other site 767468002966 H-loop/switch region; other site 767468002967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468002968 dimer interface [polypeptide binding]; other site 767468002969 conserved gate region; other site 767468002970 putative PBP binding loops; other site 767468002971 ABC-ATPase subunit interface; other site 767468002972 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 767468002973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468002974 dimer interface [polypeptide binding]; other site 767468002975 conserved gate region; other site 767468002976 putative PBP binding loops; other site 767468002977 ABC-ATPase subunit interface; other site 767468002978 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 767468002979 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 767468002980 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 767468002981 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 767468002982 Substrate-binding site [chemical binding]; other site 767468002983 Substrate specificity [chemical binding]; other site 767468002984 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 767468002985 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 767468002986 Predicted membrane protein [Function unknown]; Region: COG1511 767468002987 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 767468002988 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 767468002989 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767468002990 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767468002991 Walker A/P-loop; other site 767468002992 ATP binding site [chemical binding]; other site 767468002993 Q-loop/lid; other site 767468002994 ABC transporter signature motif; other site 767468002995 Walker B; other site 767468002996 D-loop; other site 767468002997 H-loop/switch region; other site 767468002998 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468002999 Walker A/P-loop; other site 767468003000 ATP binding site [chemical binding]; other site 767468003001 ABC transporter; Region: ABC_tran; pfam00005 767468003002 Q-loop/lid; other site 767468003003 ABC transporter signature motif; other site 767468003004 Walker B; other site 767468003005 D-loop; other site 767468003006 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 767468003007 H-loop/switch region; other site 767468003008 LytTr DNA-binding domain; Region: LytTR; pfam04397 767468003009 Enterocin A Immunity; Region: EntA_Immun; pfam08951 767468003010 methionine sulfoxide reductase A; Provisional; Region: PRK14054 767468003011 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 767468003012 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 767468003013 DNA binding residues [nucleotide binding] 767468003014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767468003015 NADH(P)-binding; Region: NAD_binding_10; pfam13460 767468003016 NAD(P) binding site [chemical binding]; other site 767468003017 active site 767468003018 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 767468003019 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 767468003020 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 767468003021 active site 767468003022 motif I; other site 767468003023 motif II; other site 767468003024 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767468003025 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 767468003026 ATP binding site [chemical binding]; other site 767468003027 Mg2+ binding site [ion binding]; other site 767468003028 G-X-G motif; other site 767468003029 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 767468003030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767468003031 active site 767468003032 phosphorylation site [posttranslational modification] 767468003033 intermolecular recognition site; other site 767468003034 dimerization interface [polypeptide binding]; other site 767468003035 LytTr DNA-binding domain; Region: LytTR; pfam04397 767468003036 CAAX protease self-immunity; Region: Abi; pfam02517 767468003037 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767468003038 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767468003039 putative DNA binding site [nucleotide binding]; other site 767468003040 putative Zn2+ binding site [ion binding]; other site 767468003041 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 767468003042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468003043 Walker A/P-loop; other site 767468003044 ATP binding site [chemical binding]; other site 767468003045 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 767468003046 Q-loop/lid; other site 767468003047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468003048 ABC transporter signature motif; other site 767468003049 Walker B; other site 767468003050 D-loop; other site 767468003051 H-loop/switch region; other site 767468003052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468003053 Walker A/P-loop; other site 767468003054 ATP binding site [chemical binding]; other site 767468003055 Q-loop/lid; other site 767468003056 ABC transporter signature motif; other site 767468003057 Walker B; other site 767468003058 D-loop; other site 767468003059 H-loop/switch region; other site 767468003060 Predicted membrane protein [Function unknown]; Region: COG2246 767468003061 GtrA-like protein; Region: GtrA; pfam04138 767468003062 Protein of unknown function (DUF1516); Region: DUF1516; pfam07457 767468003063 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 767468003064 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 767468003065 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 767468003066 FAD binding site [chemical binding]; other site 767468003067 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 767468003068 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 767468003069 THF binding site; other site 767468003070 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 767468003071 substrate binding site [chemical binding]; other site 767468003072 THF binding site; other site 767468003073 zinc-binding site [ion binding]; other site 767468003074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 767468003075 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 767468003076 ATP-sulfurylase; Region: ATPS; cd00517 767468003077 active site 767468003078 HXXH motif; other site 767468003079 flexible loop; other site 767468003080 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 767468003081 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 767468003082 TrkA-C domain; Region: TrkA_C; pfam02080 767468003083 TrkA-C domain; Region: TrkA_C; pfam02080 767468003084 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 767468003085 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 767468003086 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 767468003087 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468003088 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468003089 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 767468003090 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 767468003091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 767468003092 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 767468003093 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 767468003094 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 767468003095 active site 767468003096 HIGH motif; other site 767468003097 KMSK motif region; other site 767468003098 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 767468003099 tRNA binding surface [nucleotide binding]; other site 767468003100 anticodon binding site; other site 767468003101 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767468003102 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767468003103 Walker A/P-loop; other site 767468003104 ATP binding site [chemical binding]; other site 767468003105 Q-loop/lid; other site 767468003106 ABC transporter signature motif; other site 767468003107 Walker B; other site 767468003108 D-loop; other site 767468003109 H-loop/switch region; other site 767468003110 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767468003111 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 767468003112 FtsX-like permease family; Region: FtsX; pfam02687 767468003113 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 767468003114 Transcriptional antiterminator [Transcription]; Region: COG3933 767468003115 PRD domain; Region: PRD; pfam00874 767468003116 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 767468003117 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 767468003118 active site 767468003119 methionine cluster; other site 767468003120 phosphorylation site [posttranslational modification] 767468003121 metal binding site [ion binding]; metal-binding site 767468003122 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 767468003123 active site 767468003124 P-loop; other site 767468003125 phosphorylation site [posttranslational modification] 767468003126 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 767468003127 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 767468003128 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 767468003129 beta-galactosidase; Region: BGL; TIGR03356 767468003130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468003131 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468003132 putative substrate translocation pore; other site 767468003133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 767468003134 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 767468003135 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 767468003136 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 767468003137 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767468003138 DNA-binding site [nucleotide binding]; DNA binding site 767468003139 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767468003140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468003141 homodimer interface [polypeptide binding]; other site 767468003142 catalytic residue [active] 767468003143 LysE type translocator; Region: LysE; cl00565 767468003144 transaminase; Validated; Region: PRK07324 767468003145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767468003146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468003147 homodimer interface [polypeptide binding]; other site 767468003148 catalytic residue [active] 767468003149 Arginine repressor [Transcription]; Region: ArgR; COG1438 767468003150 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 767468003151 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 767468003152 Transglycosylase; Region: Transgly; pfam00912 767468003153 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 767468003154 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767468003155 hypothetical protein; Provisional; Region: PRK13676 767468003156 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 767468003157 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767468003158 active site 767468003159 metal binding site [ion binding]; metal-binding site 767468003160 DNA binding site [nucleotide binding] 767468003161 Uncharacterized conserved protein [Function unknown]; Region: COG4717 767468003162 Uncharacterized conserved protein [Function unknown]; Region: COG4717 767468003163 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 767468003164 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 767468003165 generic binding surface II; other site 767468003166 generic binding surface I; other site 767468003167 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767468003168 Zn2+ binding site [ion binding]; other site 767468003169 Mg2+ binding site [ion binding]; other site 767468003170 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 767468003171 Active site serine [active] 767468003172 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468003173 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767468003174 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767468003175 dimerization interface [polypeptide binding]; other site 767468003176 Predicted flavoprotein [General function prediction only]; Region: COG0431 767468003177 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767468003178 Predicted flavoprotein [General function prediction only]; Region: COG0431 767468003179 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767468003180 FMN-binding domain; Region: FMN_bind; cl01081 767468003181 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 767468003182 L-aspartate oxidase; Provisional; Region: PRK06175 767468003183 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 767468003184 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 767468003185 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 767468003186 Ligand binding site; other site 767468003187 Putative Catalytic site; other site 767468003188 DXD motif; other site 767468003189 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 767468003190 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 767468003191 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 767468003192 catalytic motif [active] 767468003193 Zn binding site [ion binding]; other site 767468003194 RibD C-terminal domain; Region: RibD_C; cl17279 767468003195 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 767468003196 Lumazine binding domain; Region: Lum_binding; pfam00677 767468003197 Lumazine binding domain; Region: Lum_binding; pfam00677 767468003198 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 767468003199 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 767468003200 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 767468003201 dimerization interface [polypeptide binding]; other site 767468003202 active site 767468003203 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 767468003204 homopentamer interface [polypeptide binding]; other site 767468003205 active site 767468003206 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 767468003207 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 767468003208 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 767468003209 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468003210 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468003211 Integrase core domain; Region: rve; pfam00665 767468003212 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767468003213 MULE transposase domain; Region: MULE; pfam10551 767468003214 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 767468003215 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767468003216 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767468003217 WxL domain surface cell wall-binding; Region: WxL; pfam13731 767468003218 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 767468003219 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 767468003220 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 767468003221 WxL domain surface cell wall-binding; Region: WxL; pfam13731 767468003222 WxL domain surface cell wall-binding; Region: WxL; pfam13731 767468003223 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 767468003224 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 767468003225 SurA N-terminal domain; Region: SurA_N; pfam09312 767468003226 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 767468003227 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 767468003228 HIT family signature motif; other site 767468003229 catalytic residue [active] 767468003230 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 767468003231 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767468003232 Walker A/P-loop; other site 767468003233 ATP binding site [chemical binding]; other site 767468003234 Q-loop/lid; other site 767468003235 ABC transporter signature motif; other site 767468003236 Walker B; other site 767468003237 D-loop; other site 767468003238 H-loop/switch region; other site 767468003239 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 767468003240 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 767468003241 active site 767468003242 substrate binding site [chemical binding]; other site 767468003243 ATP binding site [chemical binding]; other site 767468003244 Phosphotransferase enzyme family; Region: APH; pfam01636 767468003245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767468003246 S-adenosylmethionine binding site [chemical binding]; other site 767468003247 Predicted small secreted protein [Function unknown]; Region: COG5584 767468003248 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 767468003249 putative tRNA-binding site [nucleotide binding]; other site 767468003250 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 767468003251 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 767468003252 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 767468003253 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 767468003254 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767468003255 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767468003256 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767468003257 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 767468003258 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 767468003259 G1 box; other site 767468003260 GTP/Mg2+ binding site [chemical binding]; other site 767468003261 Switch I region; other site 767468003262 G2 box; other site 767468003263 G3 box; other site 767468003264 Switch II region; other site 767468003265 G4 box; other site 767468003266 G5 box; other site 767468003267 Nucleoside recognition; Region: Gate; pfam07670 767468003268 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 767468003269 Nucleoside recognition; Region: Gate; pfam07670 767468003270 FeoA domain; Region: FeoA; pfam04023 767468003271 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 767468003272 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 767468003273 Walker A/P-loop; other site 767468003274 ATP binding site [chemical binding]; other site 767468003275 Q-loop/lid; other site 767468003276 ABC transporter signature motif; other site 767468003277 Walker B; other site 767468003278 D-loop; other site 767468003279 H-loop/switch region; other site 767468003280 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 767468003281 FeS assembly protein SufD; Region: sufD; TIGR01981 767468003282 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 767468003283 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 767468003284 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767468003285 catalytic residue [active] 767468003286 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 767468003287 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 767468003288 trimerization site [polypeptide binding]; other site 767468003289 active site 767468003290 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 767468003291 FeS assembly protein SufB; Region: sufB; TIGR01980 767468003292 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 767468003293 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468003294 non-specific DNA binding site [nucleotide binding]; other site 767468003295 salt bridge; other site 767468003296 sequence-specific DNA binding site [nucleotide binding]; other site 767468003297 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 767468003298 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 767468003299 DNA polymerase I; Provisional; Region: PRK05755 767468003300 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 767468003301 active site 767468003302 metal binding site 1 [ion binding]; metal-binding site 767468003303 putative 5' ssDNA interaction site; other site 767468003304 metal binding site 3; metal-binding site 767468003305 metal binding site 2 [ion binding]; metal-binding site 767468003306 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 767468003307 putative DNA binding site [nucleotide binding]; other site 767468003308 putative metal binding site [ion binding]; other site 767468003309 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 767468003310 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 767468003311 active site 767468003312 DNA binding site [nucleotide binding] 767468003313 catalytic site [active] 767468003314 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 767468003315 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 767468003316 DNA binding site [nucleotide binding] 767468003317 catalytic residue [active] 767468003318 H2TH interface [polypeptide binding]; other site 767468003319 putative catalytic residues [active] 767468003320 turnover-facilitating residue; other site 767468003321 intercalation triad [nucleotide binding]; other site 767468003322 8OG recognition residue [nucleotide binding]; other site 767468003323 putative reading head residues; other site 767468003324 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 767468003325 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 767468003326 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 767468003327 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 767468003328 CoA-binding site [chemical binding]; other site 767468003329 ATP-binding [chemical binding]; other site 767468003330 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 767468003331 ATP cone domain; Region: ATP-cone; pfam03477 767468003332 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 767468003333 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 767468003334 primosomal protein DnaI; Reviewed; Region: PRK08939 767468003335 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 767468003336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468003337 Walker A motif; other site 767468003338 ATP binding site [chemical binding]; other site 767468003339 Walker B motif; other site 767468003340 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 767468003341 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 767468003342 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 767468003343 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 767468003344 active site 767468003345 dimer interface [polypeptide binding]; other site 767468003346 motif 1; other site 767468003347 motif 2; other site 767468003348 motif 3; other site 767468003349 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 767468003350 anticodon binding site; other site 767468003351 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 767468003352 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 767468003353 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 767468003354 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 767468003355 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 767468003356 23S rRNA binding site [nucleotide binding]; other site 767468003357 L21 binding site [polypeptide binding]; other site 767468003358 L13 binding site [polypeptide binding]; other site 767468003359 recombination factor protein RarA; Reviewed; Region: PRK13342 767468003360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468003361 Walker A motif; other site 767468003362 ATP binding site [chemical binding]; other site 767468003363 Walker B motif; other site 767468003364 arginine finger; other site 767468003365 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 767468003366 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 767468003367 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 767468003368 putative NAD(P) binding site [chemical binding]; other site 767468003369 dimer interface [polypeptide binding]; other site 767468003370 Predicted transcriptional regulators [Transcription]; Region: COG1733 767468003371 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 767468003372 aspartate racemase; Region: asp_race; TIGR00035 767468003373 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 767468003374 N-glycosyltransferase; Provisional; Region: PRK11204 767468003375 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 767468003376 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 767468003377 DXD motif; other site 767468003378 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 767468003379 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468003380 active site 767468003381 motif I; other site 767468003382 motif II; other site 767468003383 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 767468003384 Predicted GTPases [General function prediction only]; Region: COG1161 767468003385 GTP/Mg2+ binding site [chemical binding]; other site 767468003386 G4 box; other site 767468003387 G5 box; other site 767468003388 G1 box; other site 767468003389 Switch I region; other site 767468003390 G2 box; other site 767468003391 G3 box; other site 767468003392 Switch II region; other site 767468003393 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 767468003394 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 767468003395 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 767468003396 active site 767468003397 (T/H)XGH motif; other site 767468003398 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767468003399 Zn2+ binding site [ion binding]; other site 767468003400 Mg2+ binding site [ion binding]; other site 767468003401 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 767468003402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767468003403 S-adenosylmethionine binding site [chemical binding]; other site 767468003404 hypothetical protein; Provisional; Region: PRK13670 767468003405 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 767468003406 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 767468003407 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 767468003408 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 767468003409 Predicted membrane protein [Function unknown]; Region: COG3212 767468003410 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 767468003411 Cation efflux family; Region: Cation_efflux; pfam01545 767468003412 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 767468003413 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 767468003414 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 767468003415 recombination factor protein RarA; Reviewed; Region: PRK13342 767468003416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468003417 Walker A motif; other site 767468003418 ATP binding site [chemical binding]; other site 767468003419 Walker B motif; other site 767468003420 arginine finger; other site 767468003421 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 767468003422 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767468003423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767468003424 intermolecular recognition site; other site 767468003425 active site 767468003426 dimerization interface [polypeptide binding]; other site 767468003427 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767468003428 DNA binding site [nucleotide binding] 767468003429 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767468003430 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767468003431 dimerization interface [polypeptide binding]; other site 767468003432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767468003433 dimer interface [polypeptide binding]; other site 767468003434 phosphorylation site [posttranslational modification] 767468003435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767468003436 ATP binding site [chemical binding]; other site 767468003437 Mg2+ binding site [ion binding]; other site 767468003438 G-X-G motif; other site 767468003439 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 767468003440 UbiA prenyltransferase family; Region: UbiA; pfam01040 767468003441 exonuclease SbcC; Region: sbcc; TIGR00618 767468003442 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 767468003443 Walker A/P-loop; other site 767468003444 ATP binding site [chemical binding]; other site 767468003445 Q-loop/lid; other site 767468003446 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 767468003447 ABC transporter signature motif; other site 767468003448 Walker B; other site 767468003449 D-loop; other site 767468003450 H-loop/switch region; other site 767468003451 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 767468003452 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767468003453 active site 767468003454 metal binding site [ion binding]; metal-binding site 767468003455 DNA binding site [nucleotide binding] 767468003456 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 767468003457 SdpI/YhfL protein family; Region: SdpI; pfam13630 767468003458 OxaA-like protein precursor; Provisional; Region: PRK02463 767468003459 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 767468003460 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 767468003461 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 767468003462 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 767468003463 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 767468003464 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 767468003465 Predicted transcriptional regulators [Transcription]; Region: COG1733 767468003466 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 767468003467 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 767468003468 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 767468003469 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 767468003470 dimer interface [polypeptide binding]; other site 767468003471 motif 1; other site 767468003472 active site 767468003473 motif 2; other site 767468003474 motif 3; other site 767468003475 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 767468003476 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 767468003477 putative tRNA-binding site [nucleotide binding]; other site 767468003478 B3/4 domain; Region: B3_4; pfam03483 767468003479 tRNA synthetase B5 domain; Region: B5; smart00874 767468003480 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 767468003481 dimer interface [polypeptide binding]; other site 767468003482 motif 1; other site 767468003483 motif 3; other site 767468003484 motif 2; other site 767468003485 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 767468003486 YceG-like family; Region: YceG; pfam02618 767468003487 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 767468003488 dimerization interface [polypeptide binding]; other site 767468003489 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 767468003490 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 767468003491 Sugar specificity; other site 767468003492 Pyrimidine base specificity; other site 767468003493 ATP-binding site [chemical binding]; other site 767468003494 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 767468003495 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 767468003496 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 767468003497 LytTr DNA-binding domain; Region: LytTR; pfam04397 767468003498 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 767468003499 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 767468003500 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 767468003501 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 767468003502 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767468003503 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 767468003504 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 767468003505 Rhomboid family; Region: Rhomboid; pfam01694 767468003506 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 767468003507 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 767468003508 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 767468003509 nucleotide binding site [chemical binding]; other site 767468003510 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 767468003511 catalytic triad [active] 767468003512 active site nucleophile [active] 767468003513 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 767468003514 active site residue [active] 767468003515 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 767468003516 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 767468003517 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 767468003518 active site 767468003519 catalytic site [active] 767468003520 metal binding site [ion binding]; metal-binding site 767468003521 dimer interface [polypeptide binding]; other site 767468003522 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 767468003523 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 767468003524 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 767468003525 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 767468003526 DNA binding residues [nucleotide binding] 767468003527 putative dimer interface [polypeptide binding]; other site 767468003528 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 767468003529 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 767468003530 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 767468003531 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 767468003532 dUTPase; Region: dUTPase_2; pfam08761 767468003533 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 767468003534 homodimer interface [polypeptide binding]; other site 767468003535 metal binding site [ion binding]; metal-binding site 767468003536 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468003537 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 767468003538 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 767468003539 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 767468003540 Protein of unknown function (DUF464); Region: DUF464; pfam04327 767468003541 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 767468003542 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 767468003543 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 767468003544 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 767468003545 active site 767468003546 elongation factor P; Validated; Region: PRK00529 767468003547 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 767468003548 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 767468003549 RNA binding site [nucleotide binding]; other site 767468003550 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 767468003551 RNA binding site [nucleotide binding]; other site 767468003552 Asp23 family; Region: Asp23; pfam03780 767468003553 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 767468003554 putative RNA binding site [nucleotide binding]; other site 767468003555 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 767468003556 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 767468003557 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 767468003558 homodimer interface [polypeptide binding]; other site 767468003559 NADP binding site [chemical binding]; other site 767468003560 substrate binding site [chemical binding]; other site 767468003561 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 767468003562 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 767468003563 generic binding surface II; other site 767468003564 generic binding surface I; other site 767468003565 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 767468003566 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 767468003567 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 767468003568 substrate binding pocket [chemical binding]; other site 767468003569 chain length determination region; other site 767468003570 substrate-Mg2+ binding site; other site 767468003571 catalytic residues [active] 767468003572 aspartate-rich region 1; other site 767468003573 active site lid residues [active] 767468003574 aspartate-rich region 2; other site 767468003575 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 767468003576 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 767468003577 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 767468003578 arginine repressor; Provisional; Region: PRK04280 767468003579 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 767468003580 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 767468003581 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 767468003582 Walker A/P-loop; other site 767468003583 ATP binding site [chemical binding]; other site 767468003584 Q-loop/lid; other site 767468003585 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 767468003586 ABC transporter signature motif; other site 767468003587 Walker B; other site 767468003588 D-loop; other site 767468003589 H-loop/switch region; other site 767468003590 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 767468003591 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 767468003592 Walker A/P-loop; other site 767468003593 ATP binding site [chemical binding]; other site 767468003594 Q-loop/lid; other site 767468003595 ABC transporter signature motif; other site 767468003596 Walker B; other site 767468003597 D-loop; other site 767468003598 H-loop/switch region; other site 767468003599 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 767468003600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468003601 dimer interface [polypeptide binding]; other site 767468003602 conserved gate region; other site 767468003603 putative PBP binding loops; other site 767468003604 ABC-ATPase subunit interface; other site 767468003605 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 767468003606 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 767468003607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468003608 dimer interface [polypeptide binding]; other site 767468003609 conserved gate region; other site 767468003610 putative PBP binding loops; other site 767468003611 ABC-ATPase subunit interface; other site 767468003612 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 767468003613 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 767468003614 catalytic site [active] 767468003615 G-X2-G-X-G-K; other site 767468003616 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 767468003617 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 767468003618 Flavoprotein; Region: Flavoprotein; pfam02441 767468003619 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 767468003620 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 767468003621 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767468003622 ATP binding site [chemical binding]; other site 767468003623 putative Mg++ binding site [ion binding]; other site 767468003624 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767468003625 nucleotide binding region [chemical binding]; other site 767468003626 ATP-binding site [chemical binding]; other site 767468003627 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 767468003628 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 767468003629 putative active site [active] 767468003630 substrate binding site [chemical binding]; other site 767468003631 putative cosubstrate binding site; other site 767468003632 catalytic site [active] 767468003633 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 767468003634 substrate binding site [chemical binding]; other site 767468003635 16S rRNA methyltransferase B; Provisional; Region: PRK14902 767468003636 NusB family; Region: NusB; pfam01029 767468003637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767468003638 S-adenosylmethionine binding site [chemical binding]; other site 767468003639 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 767468003640 active site 767468003641 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 767468003642 Catalytic domain of Protein Kinases; Region: PKc; cd00180 767468003643 active site 767468003644 ATP binding site [chemical binding]; other site 767468003645 substrate binding site [chemical binding]; other site 767468003646 activation loop (A-loop); other site 767468003647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 767468003648 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 767468003649 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 767468003650 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 767468003651 GTPase RsgA; Reviewed; Region: PRK00098 767468003652 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 767468003653 RNA binding site [nucleotide binding]; other site 767468003654 homodimer interface [polypeptide binding]; other site 767468003655 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 767468003656 GTPase/Zn-binding domain interface [polypeptide binding]; other site 767468003657 GTP/Mg2+ binding site [chemical binding]; other site 767468003658 G4 box; other site 767468003659 G5 box; other site 767468003660 G1 box; other site 767468003661 Switch I region; other site 767468003662 G2 box; other site 767468003663 G3 box; other site 767468003664 Switch II region; other site 767468003665 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 767468003666 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 767468003667 substrate binding site [chemical binding]; other site 767468003668 hexamer interface [polypeptide binding]; other site 767468003669 metal binding site [ion binding]; metal-binding site 767468003670 Thiamine pyrophosphokinase; Region: TPK; cd07995 767468003671 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 767468003672 active site 767468003673 dimerization interface [polypeptide binding]; other site 767468003674 thiamine binding site [chemical binding]; other site 767468003675 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 767468003676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 767468003677 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 767468003678 DAK2 domain; Region: Dak2; pfam02734 767468003679 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 767468003680 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 767468003681 generic binding surface II; other site 767468003682 ssDNA binding site; other site 767468003683 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767468003684 ATP binding site [chemical binding]; other site 767468003685 putative Mg++ binding site [ion binding]; other site 767468003686 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767468003687 nucleotide binding region [chemical binding]; other site 767468003688 ATP-binding site [chemical binding]; other site 767468003689 putative phosphate acyltransferase; Provisional; Region: PRK05331 767468003690 acyl carrier protein; Provisional; Region: acpP; PRK00982 767468003691 ribonuclease III; Reviewed; Region: rnc; PRK00102 767468003692 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 767468003693 dimerization interface [polypeptide binding]; other site 767468003694 active site 767468003695 metal binding site [ion binding]; metal-binding site 767468003696 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 767468003697 dsRNA binding site [nucleotide binding]; other site 767468003698 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 767468003699 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 767468003700 Walker A/P-loop; other site 767468003701 ATP binding site [chemical binding]; other site 767468003702 Q-loop/lid; other site 767468003703 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 767468003704 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 767468003705 ABC transporter signature motif; other site 767468003706 Walker B; other site 767468003707 D-loop; other site 767468003708 H-loop/switch region; other site 767468003709 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 767468003710 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 767468003711 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 767468003712 P loop; other site 767468003713 GTP binding site [chemical binding]; other site 767468003714 putative DNA-binding protein; Validated; Region: PRK00118 767468003715 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 767468003716 signal recognition particle protein; Provisional; Region: PRK10867 767468003717 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 767468003718 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 767468003719 P loop; other site 767468003720 GTP binding site [chemical binding]; other site 767468003721 Signal peptide binding domain; Region: SRP_SPB; pfam02978 767468003722 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 767468003723 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 767468003724 KH domain; Region: KH_4; pfam13083 767468003725 G-X-X-G motif; other site 767468003726 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 767468003727 RimM N-terminal domain; Region: RimM; pfam01782 767468003728 PRC-barrel domain; Region: PRC; pfam05239 767468003729 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 767468003730 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 767468003731 Enterocin A Immunity; Region: EntA_Immun; pfam08951 767468003732 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 767468003733 MucBP domain; Region: MucBP; pfam06458 767468003734 MucBP domain; Region: MucBP; pfam06458 767468003735 MucBP domain; Region: MucBP; pfam06458 767468003736 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 767468003737 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 767468003738 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767468003739 Walker A/P-loop; other site 767468003740 ATP binding site [chemical binding]; other site 767468003741 Q-loop/lid; other site 767468003742 ABC transporter signature motif; other site 767468003743 Walker B; other site 767468003744 D-loop; other site 767468003745 H-loop/switch region; other site 767468003746 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 767468003747 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 767468003748 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 767468003749 Glutamine amidotransferase class-I; Region: GATase; pfam00117 767468003750 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 767468003751 glutamine binding [chemical binding]; other site 767468003752 catalytic triad [active] 767468003753 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 767468003754 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 767468003755 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 767468003756 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 767468003757 active site 767468003758 ribulose/triose binding site [chemical binding]; other site 767468003759 phosphate binding site [ion binding]; other site 767468003760 substrate (anthranilate) binding pocket [chemical binding]; other site 767468003761 product (indole) binding pocket [chemical binding]; other site 767468003762 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 767468003763 active site 767468003764 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 767468003765 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 767468003766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468003767 catalytic residue [active] 767468003768 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 767468003769 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 767468003770 substrate binding site [chemical binding]; other site 767468003771 active site 767468003772 catalytic residues [active] 767468003773 heterodimer interface [polypeptide binding]; other site 767468003774 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 767468003775 Isochorismatase family; Region: Isochorismatase; pfam00857 767468003776 catalytic triad [active] 767468003777 conserved cis-peptide bond; other site 767468003778 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 767468003779 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 767468003780 NAD(P) binding site [chemical binding]; other site 767468003781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 767468003782 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 767468003783 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 767468003784 metal binding site [ion binding]; metal-binding site 767468003785 dimer interface [polypeptide binding]; other site 767468003786 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 767468003787 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 767468003788 catalytic Zn binding site [ion binding]; other site 767468003789 NAD(P) binding site [chemical binding]; other site 767468003790 structural Zn binding site [ion binding]; other site 767468003791 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 767468003792 short chain dehydrogenase; Validated; Region: PRK06182 767468003793 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 767468003794 NADP binding site [chemical binding]; other site 767468003795 active site 767468003796 steroid binding site; other site 767468003797 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 767468003798 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 767468003799 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767468003800 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 767468003801 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 767468003802 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 767468003803 dimer interface [polypeptide binding]; other site 767468003804 active site 767468003805 CoA binding pocket [chemical binding]; other site 767468003806 acyl carrier protein; Provisional; Region: acpP; PRK00982 767468003807 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 767468003808 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 767468003809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767468003810 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 767468003811 NAD(P) binding site [chemical binding]; other site 767468003812 active site 767468003813 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 767468003814 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 767468003815 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 767468003816 carboxyltransferase (CT) interaction site; other site 767468003817 biotinylation site [posttranslational modification]; other site 767468003818 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 767468003819 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 767468003820 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767468003821 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767468003822 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 767468003823 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 767468003824 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 767468003825 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 767468003826 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 767468003827 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 767468003828 NAD binding site [chemical binding]; other site 767468003829 homotetramer interface [polypeptide binding]; other site 767468003830 homodimer interface [polypeptide binding]; other site 767468003831 substrate binding site [chemical binding]; other site 767468003832 active site 767468003833 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 767468003834 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 767468003835 Protein of unknown function (DUF554); Region: DUF554; pfam04474 767468003836 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468003837 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767468003838 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767468003839 dimerization interface [polypeptide binding]; other site 767468003840 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 767468003841 GTPase RsgA; Reviewed; Region: PRK01889 767468003842 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 767468003843 RNA binding site [nucleotide binding]; other site 767468003844 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 767468003845 GTPase/Zn-binding domain interface [polypeptide binding]; other site 767468003846 GTP/Mg2+ binding site [chemical binding]; other site 767468003847 G4 box; other site 767468003848 G5 box; other site 767468003849 G1 box; other site 767468003850 Switch I region; other site 767468003851 G2 box; other site 767468003852 G3 box; other site 767468003853 Switch II region; other site 767468003854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468003855 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767468003856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468003857 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468003858 putative substrate translocation pore; other site 767468003859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468003860 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 767468003861 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 767468003862 Enterocin A Immunity; Region: EntA_Immun; pfam08951 767468003863 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 767468003864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767468003865 S-adenosylmethionine binding site [chemical binding]; other site 767468003866 putative transposase OrfB; Reviewed; Region: PHA02517 767468003867 Integrase core domain; Region: rve; pfam00665 767468003868 Chitin binding domain; Region: Chitin_bind_3; pfam03067 767468003869 Uncharacterized conserved protein [Function unknown]; Region: COG1359 767468003870 TspO/MBR family; Region: TspO_MBR; pfam03073 767468003871 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767468003872 Ligand Binding Site [chemical binding]; other site 767468003873 Protein of unknown function (DUF805); Region: DUF805; pfam05656 767468003874 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 767468003875 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 767468003876 Predicted membrane protein [Function unknown]; Region: COG2261 767468003877 CsbD-like; Region: CsbD; cl17424 767468003878 Peptidase family C69; Region: Peptidase_C69; pfam03577 767468003879 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 767468003880 active site 1 [active] 767468003881 dimer interface [polypeptide binding]; other site 767468003882 hexamer interface [polypeptide binding]; other site 767468003883 active site 2 [active] 767468003884 diaminopimelate decarboxylase; Region: lysA; TIGR01048 767468003885 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 767468003886 active site 767468003887 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 767468003888 substrate binding site [chemical binding]; other site 767468003889 catalytic residues [active] 767468003890 dimer interface [polypeptide binding]; other site 767468003891 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 767468003892 UbiA prenyltransferase family; Region: UbiA; pfam01040 767468003893 Ion channel; Region: Ion_trans_2; pfam07885 767468003894 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 767468003895 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 767468003896 inhibitor-cofactor binding pocket; inhibition site 767468003897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468003898 catalytic residue [active] 767468003899 amino acid transporter; Region: 2A0306; TIGR00909 767468003900 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 767468003901 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 767468003902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468003903 active site 767468003904 motif I; other site 767468003905 motif II; other site 767468003906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 767468003907 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 767468003908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767468003909 S-adenosylmethionine binding site [chemical binding]; other site 767468003910 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 767468003911 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 767468003912 Double zinc ribbon; Region: DZR; pfam12773 767468003913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468003914 putative substrate translocation pore; other site 767468003915 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468003916 maltose phosphorylase; Provisional; Region: PRK13807 767468003917 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 767468003918 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 767468003919 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 767468003920 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 767468003921 active site 767468003922 catalytic residues [active] 767468003923 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 767468003924 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 767468003925 homotetramer interface [polypeptide binding]; other site 767468003926 FMN binding site [chemical binding]; other site 767468003927 homodimer contacts [polypeptide binding]; other site 767468003928 putative active site [active] 767468003929 putative substrate binding site [chemical binding]; other site 767468003930 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 767468003931 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767468003932 diphosphomevalonate decarboxylase; Region: PLN02407 767468003933 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 767468003934 mevalonate kinase; Region: mevalon_kin; TIGR00549 767468003935 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767468003936 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 767468003937 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 767468003938 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 767468003939 active site 767468003940 catalytic site [active] 767468003941 substrate binding site [chemical binding]; other site 767468003942 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767468003943 ATP binding site [chemical binding]; other site 767468003944 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 767468003945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 767468003946 aspartate aminotransferase; Provisional; Region: PRK05764 767468003947 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767468003948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468003949 homodimer interface [polypeptide binding]; other site 767468003950 catalytic residue [active] 767468003951 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 767468003952 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 767468003953 Dimer interface [polypeptide binding]; other site 767468003954 anticodon binding site; other site 767468003955 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 767468003956 homodimer interface [polypeptide binding]; other site 767468003957 motif 1; other site 767468003958 motif 2; other site 767468003959 active site 767468003960 motif 3; other site 767468003961 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 767468003962 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 767468003963 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 767468003964 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 767468003965 Walker A/P-loop; other site 767468003966 ATP binding site [chemical binding]; other site 767468003967 Q-loop/lid; other site 767468003968 ABC transporter signature motif; other site 767468003969 Walker B; other site 767468003970 D-loop; other site 767468003971 H-loop/switch region; other site 767468003972 NIL domain; Region: NIL; pfam09383 767468003973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468003974 dimer interface [polypeptide binding]; other site 767468003975 conserved gate region; other site 767468003976 ABC-ATPase subunit interface; other site 767468003977 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 767468003978 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 767468003979 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767468003980 Ligand Binding Site [chemical binding]; other site 767468003981 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 767468003982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468003983 dimer interface [polypeptide binding]; other site 767468003984 conserved gate region; other site 767468003985 putative PBP binding loops; other site 767468003986 ABC-ATPase subunit interface; other site 767468003987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468003988 dimer interface [polypeptide binding]; other site 767468003989 conserved gate region; other site 767468003990 putative PBP binding loops; other site 767468003991 ABC-ATPase subunit interface; other site 767468003992 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 767468003993 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 767468003994 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 767468003995 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 767468003996 Walker A/P-loop; other site 767468003997 ATP binding site [chemical binding]; other site 767468003998 Q-loop/lid; other site 767468003999 ABC transporter signature motif; other site 767468004000 Walker B; other site 767468004001 D-loop; other site 767468004002 H-loop/switch region; other site 767468004003 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 767468004004 Transglycosylase; Region: Transgly; pfam00912 767468004005 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767468004006 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 767468004007 hypothetical protein; Provisional; Region: PRK13660 767468004008 cell division protein GpsB; Provisional; Region: PRK14127 767468004009 DivIVA domain; Region: DivI1A_domain; TIGR03544 767468004010 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 767468004011 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 767468004012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 767468004013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767468004014 dimerization interface [polypeptide binding]; other site 767468004015 putative DNA binding site [nucleotide binding]; other site 767468004016 putative Zn2+ binding site [ion binding]; other site 767468004017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468004018 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468004019 putative substrate translocation pore; other site 767468004020 esterase; Provisional; Region: PRK10566 767468004021 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767468004022 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 767468004023 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767468004024 active site 767468004025 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 767468004026 putative dimer interface [polypeptide binding]; other site 767468004027 catalytic triad [active] 767468004028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468004029 Coenzyme A binding pocket [chemical binding]; other site 767468004030 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468004031 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468004032 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 767468004033 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 767468004034 active site 767468004035 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 767468004036 putative dimer interface [polypeptide binding]; other site 767468004037 catalytic triad [active] 767468004038 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767468004039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 767468004040 Walker A/P-loop; other site 767468004041 ATP binding site [chemical binding]; other site 767468004042 Q-loop/lid; other site 767468004043 ABC transporter signature motif; other site 767468004044 Walker B; other site 767468004045 D-loop; other site 767468004046 H-loop/switch region; other site 767468004047 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 767468004048 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 767468004049 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767468004050 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 767468004051 RNA/DNA hybrid binding site [nucleotide binding]; other site 767468004052 active site 767468004053 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 767468004054 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 767468004055 Potassium binding sites [ion binding]; other site 767468004056 Cesium cation binding sites [ion binding]; other site 767468004057 lipoprotein signal peptidase; Provisional; Region: PRK14797 767468004058 lipoprotein signal peptidase; Provisional; Region: PRK14787 767468004059 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767468004060 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767468004061 RNA binding surface [nucleotide binding]; other site 767468004062 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767468004063 active site 767468004064 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 767468004065 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767468004066 active site 767468004067 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 767468004068 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 767468004069 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 767468004070 catalytic site [active] 767468004071 subunit interface [polypeptide binding]; other site 767468004072 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767468004073 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 767468004074 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767468004075 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 767468004076 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 767468004077 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767468004078 catalytic core [active] 767468004079 Domain of unknown function (DU1801); Region: DUF1801; cl17490 767468004080 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 767468004081 Chloramphenicol acetyltransferase; Region: CAT; smart01059 767468004082 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 767468004083 GIY-YIG motif/motif A; other site 767468004084 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 767468004085 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 767468004086 nudix motif; other site 767468004087 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767468004088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468004089 Walker A/P-loop; other site 767468004090 ATP binding site [chemical binding]; other site 767468004091 Q-loop/lid; other site 767468004092 ABC transporter signature motif; other site 767468004093 Walker B; other site 767468004094 D-loop; other site 767468004095 H-loop/switch region; other site 767468004096 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 767468004097 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 767468004098 Domain of unknown function (DUF814); Region: DUF814; pfam05670 767468004099 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767468004100 MarR family; Region: MarR_2; pfam12802 767468004101 EDD domain protein, DegV family; Region: DegV; TIGR00762 767468004102 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767468004103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468004104 Coenzyme A binding pocket [chemical binding]; other site 767468004105 Protein of unknown function (DUF975); Region: DUF975; cl10504 767468004106 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 767468004107 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 767468004108 nucleotide binding site/active site [active] 767468004109 HIT family signature motif; other site 767468004110 catalytic residue [active] 767468004111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468004112 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468004113 putative substrate translocation pore; other site 767468004114 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 767468004115 Predicted membrane protein [Function unknown]; Region: COG4420 767468004116 Predicted membrane protein [Function unknown]; Region: COG2035 767468004117 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 767468004118 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 767468004119 L-lactate permease; Region: Lactate_perm; cl00701 767468004120 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 767468004121 substrate binding site; other site 767468004122 dimer interface; other site 767468004123 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 767468004124 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 767468004125 putative NAD(P) binding site [chemical binding]; other site 767468004126 putative catalytic Zn binding site [ion binding]; other site 767468004127 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 767468004128 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 767468004129 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 767468004130 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 767468004131 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 767468004132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468004133 Coenzyme A binding pocket [chemical binding]; other site 767468004134 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767468004135 MarR family; Region: MarR; pfam01047 767468004136 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 767468004137 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767468004138 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767468004139 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 767468004140 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 767468004141 active site 767468004142 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 767468004143 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 767468004144 methionine sulfoxide reductase A; Provisional; Region: PRK14054 767468004145 methionine sulfoxide reductase B; Provisional; Region: PRK00222 767468004146 SelR domain; Region: SelR; pfam01641 767468004147 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 767468004148 DHH family; Region: DHH; pfam01368 767468004149 DHHA2 domain; Region: DHHA2; pfam02833 767468004150 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468004151 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767468004152 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767468004153 dimerization interface [polypeptide binding]; other site 767468004154 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 767468004155 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 767468004156 CAP-like domain; other site 767468004157 active site 767468004158 primary dimer interface [polypeptide binding]; other site 767468004159 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767468004160 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 767468004161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767468004162 ATP binding site [chemical binding]; other site 767468004163 Mg2+ binding site [ion binding]; other site 767468004164 G-X-G motif; other site 767468004165 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 767468004166 anchoring element; other site 767468004167 dimer interface [polypeptide binding]; other site 767468004168 ATP binding site [chemical binding]; other site 767468004169 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 767468004170 active site 767468004171 putative metal-binding site [ion binding]; other site 767468004172 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 767468004173 membrane protein; Provisional; Region: PRK14392 767468004174 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 767468004175 active site 767468004176 catalytic residues [active] 767468004177 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 767468004178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468004179 Walker A motif; other site 767468004180 ATP binding site [chemical binding]; other site 767468004181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468004182 Walker B motif; other site 767468004183 arginine finger; other site 767468004184 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 767468004185 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 767468004186 active site 767468004187 HslU subunit interaction site [polypeptide binding]; other site 767468004188 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 767468004189 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767468004190 active site 767468004191 DNA binding site [nucleotide binding] 767468004192 Int/Topo IB signature motif; other site 767468004193 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 767468004194 Glucose inhibited division protein A; Region: GIDA; pfam01134 767468004195 DNA topoisomerase I; Validated; Region: PRK05582 767468004196 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 767468004197 active site 767468004198 interdomain interaction site; other site 767468004199 putative metal-binding site [ion binding]; other site 767468004200 nucleotide binding site [chemical binding]; other site 767468004201 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 767468004202 domain I; other site 767468004203 DNA binding groove [nucleotide binding] 767468004204 phosphate binding site [ion binding]; other site 767468004205 domain II; other site 767468004206 domain III; other site 767468004207 nucleotide binding site [chemical binding]; other site 767468004208 catalytic site [active] 767468004209 domain IV; other site 767468004210 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 767468004211 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 767468004212 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 767468004213 DNA protecting protein DprA; Region: dprA; TIGR00732 767468004214 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 767468004215 RNA/DNA hybrid binding site [nucleotide binding]; other site 767468004216 active site 767468004217 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 767468004218 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 767468004219 GTP/Mg2+ binding site [chemical binding]; other site 767468004220 G4 box; other site 767468004221 G5 box; other site 767468004222 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 767468004223 G1 box; other site 767468004224 G1 box; other site 767468004225 GTP/Mg2+ binding site [chemical binding]; other site 767468004226 Switch I region; other site 767468004227 G2 box; other site 767468004228 G2 box; other site 767468004229 G3 box; other site 767468004230 G3 box; other site 767468004231 Switch II region; other site 767468004232 Switch II region; other site 767468004233 G4 box; other site 767468004234 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 767468004235 substrate binding site [chemical binding]; other site 767468004236 THF binding site; other site 767468004237 zinc-binding site [ion binding]; other site 767468004238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468004239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767468004240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767468004241 dimerization interface [polypeptide binding]; other site 767468004242 Mrr N-terminal domain; Region: Mrr_N; pfam14338 767468004243 Restriction endonuclease; Region: Mrr_cat; pfam04471 767468004244 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 767468004245 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 767468004246 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 767468004247 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 767468004248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468004249 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468004250 putative substrate translocation pore; other site 767468004251 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 767468004252 C-terminal peptidase (prc); Region: prc; TIGR00225 767468004253 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 767468004254 protein binding site [polypeptide binding]; other site 767468004255 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 767468004256 Catalytic dyad [active] 767468004257 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 767468004258 hypothetical protein; Provisional; Region: PRK13672 767468004259 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 767468004260 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 767468004261 active site 767468004262 catalytic triad [active] 767468004263 oxyanion hole [active] 767468004264 EDD domain protein, DegV family; Region: DegV; TIGR00762 767468004265 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767468004266 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 767468004267 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 767468004268 folate binding site [chemical binding]; other site 767468004269 NADP+ binding site [chemical binding]; other site 767468004270 thymidylate synthase; Region: thym_sym; TIGR03284 767468004271 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 767468004272 dimerization interface [polypeptide binding]; other site 767468004273 active site 767468004274 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 767468004275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468004276 Walker A/P-loop; other site 767468004277 ATP binding site [chemical binding]; other site 767468004278 Q-loop/lid; other site 767468004279 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767468004280 ABC transporter signature motif; other site 767468004281 Walker B; other site 767468004282 D-loop; other site 767468004283 ABC transporter; Region: ABC_tran_2; pfam12848 767468004284 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767468004285 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 767468004286 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 767468004287 active site 767468004288 NTP binding site [chemical binding]; other site 767468004289 metal binding triad [ion binding]; metal-binding site 767468004290 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 767468004291 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 767468004292 dihydrodipicolinate reductase; Provisional; Region: PRK00048 767468004293 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 767468004294 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 767468004295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 767468004296 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767468004297 active site 767468004298 motif I; other site 767468004299 motif II; other site 767468004300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468004301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767468004302 binding surface 767468004303 TPR motif; other site 767468004304 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 767468004305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767468004306 binding surface 767468004307 TPR motif; other site 767468004308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767468004309 binding surface 767468004310 TPR motif; other site 767468004311 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 767468004312 IHF dimer interface [polypeptide binding]; other site 767468004313 IHF - DNA interface [nucleotide binding]; other site 767468004314 GTP-binding protein Der; Reviewed; Region: PRK00093 767468004315 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 767468004316 G1 box; other site 767468004317 GTP/Mg2+ binding site [chemical binding]; other site 767468004318 Switch I region; other site 767468004319 G2 box; other site 767468004320 Switch II region; other site 767468004321 G3 box; other site 767468004322 G4 box; other site 767468004323 G5 box; other site 767468004324 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 767468004325 G1 box; other site 767468004326 GTP/Mg2+ binding site [chemical binding]; other site 767468004327 Switch I region; other site 767468004328 G2 box; other site 767468004329 G3 box; other site 767468004330 Switch II region; other site 767468004331 G4 box; other site 767468004332 G5 box; other site 767468004333 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 767468004334 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 767468004335 RNA binding site [nucleotide binding]; other site 767468004336 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 767468004337 RNA binding site [nucleotide binding]; other site 767468004338 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 767468004339 RNA binding site [nucleotide binding]; other site 767468004340 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 767468004341 RNA binding site [nucleotide binding]; other site 767468004342 cytidylate kinase; Provisional; Region: cmk; PRK00023 767468004343 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 767468004344 CMP-binding site; other site 767468004345 The sites determining sugar specificity; other site 767468004346 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767468004347 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 767468004348 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767468004349 ATP binding site [chemical binding]; other site 767468004350 putative Mg++ binding site [ion binding]; other site 767468004351 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767468004352 nucleotide binding region [chemical binding]; other site 767468004353 ATP-binding site [chemical binding]; other site 767468004354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 767468004355 Predicted membrane protein [Function unknown]; Region: COG3601 767468004356 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 767468004357 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 767468004358 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767468004359 RNA binding surface [nucleotide binding]; other site 767468004360 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 767468004361 active site 767468004362 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 767468004363 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 767468004364 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 767468004365 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 767468004366 active site 767468004367 Int/Topo IB signature motif; other site 767468004368 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 767468004369 S1 domain; Region: S1_2; pfam13509 767468004370 Protein of unknown function (DUF441); Region: DUF441; pfam04284 767468004371 pyruvate kinase; Provisional; Region: PRK06354 767468004372 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 767468004373 domain interfaces; other site 767468004374 active site 767468004375 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 767468004376 6-phosphofructokinase; Provisional; Region: PRK03202 767468004377 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 767468004378 active site 767468004379 ADP/pyrophosphate binding site [chemical binding]; other site 767468004380 dimerization interface [polypeptide binding]; other site 767468004381 allosteric effector site; other site 767468004382 fructose-1,6-bisphosphate binding site; other site 767468004383 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 767468004384 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 767468004385 active site 767468004386 PHP Thumb interface [polypeptide binding]; other site 767468004387 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 767468004388 generic binding surface I; other site 767468004389 generic binding surface II; other site 767468004390 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 767468004391 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 767468004392 Clp amino terminal domain; Region: Clp_N; pfam02861 767468004393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468004394 Walker A motif; other site 767468004395 ATP binding site [chemical binding]; other site 767468004396 Walker B motif; other site 767468004397 arginine finger; other site 767468004398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468004399 Walker A motif; other site 767468004400 ATP binding site [chemical binding]; other site 767468004401 Walker B motif; other site 767468004402 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 767468004403 peptidase T; Region: peptidase-T; TIGR01882 767468004404 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 767468004405 metal binding site [ion binding]; metal-binding site 767468004406 dimer interface [polypeptide binding]; other site 767468004407 Uncharacterized conserved protein [Function unknown]; Region: COG0327 767468004408 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 767468004409 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 767468004410 Uncharacterized conserved protein [Function unknown]; Region: COG0327 767468004411 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 767468004412 Family of unknown function (DUF633); Region: DUF633; pfam04816 767468004413 O-Antigen ligase; Region: Wzy_C; pfam04932 767468004414 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 767468004415 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 767468004416 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468004417 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 767468004418 Walker A/P-loop; other site 767468004419 ATP binding site [chemical binding]; other site 767468004420 Q-loop/lid; other site 767468004421 ABC transporter signature motif; other site 767468004422 Walker B; other site 767468004423 D-loop; other site 767468004424 H-loop/switch region; other site 767468004425 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767468004426 MarR family; Region: MarR_2; pfam12802 767468004427 phosphoenolpyruvate synthase; Validated; Region: PRK06464 767468004428 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 767468004429 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 767468004430 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 767468004431 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 767468004432 active site residue [active] 767468004433 MarR family; Region: MarR_2; cl17246 767468004434 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767468004435 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 767468004436 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 767468004437 putative NAD(P) binding site [chemical binding]; other site 767468004438 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 767468004439 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 767468004440 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767468004441 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 767468004442 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767468004443 enolase; Provisional; Region: eno; PRK00077 767468004444 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 767468004445 dimer interface [polypeptide binding]; other site 767468004446 metal binding site [ion binding]; metal-binding site 767468004447 substrate binding pocket [chemical binding]; other site 767468004448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468004449 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468004450 putative substrate translocation pore; other site 767468004451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468004452 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767468004453 MarR family; Region: MarR_2; pfam12802 767468004454 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 767468004455 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 767468004456 metal binding site [ion binding]; metal-binding site 767468004457 dimer interface [polypeptide binding]; other site 767468004458 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 767468004459 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767468004460 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767468004461 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 767468004462 active site residue [active] 767468004463 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 767468004464 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 767468004465 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 767468004466 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 767468004467 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 767468004468 nudix motif; other site 767468004469 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 767468004470 ArsC family; Region: ArsC; pfam03960 767468004471 putative catalytic residues [active] 767468004472 thiol/disulfide switch; other site 767468004473 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 767468004474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767468004475 NADH(P)-binding; Region: NAD_binding_10; pfam13460 767468004476 NAD(P) binding site [chemical binding]; other site 767468004477 active site 767468004478 Uncharacterized conserved protein [Function unknown]; Region: COG4715 767468004479 tetratricopeptide repeat protein; Provisional; Region: PRK11788 767468004480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767468004481 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 767468004482 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468004483 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 767468004484 DNA-binding interface [nucleotide binding]; DNA binding site 767468004485 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767468004486 putative transposase OrfB; Reviewed; Region: PHA02517 767468004487 HTH-like domain; Region: HTH_21; pfam13276 767468004488 Integrase core domain; Region: rve; pfam00665 767468004489 Integrase core domain; Region: rve_2; pfam13333 767468004490 Winged helix-turn helix; Region: HTH_29; pfam13551 767468004491 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468004492 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767468004493 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468004494 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 767468004495 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 767468004496 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468004497 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468004498 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 767468004499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468004500 motif II; other site 767468004501 maltose O-acetyltransferase; Provisional; Region: PRK10092 767468004502 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 767468004503 active site 767468004504 substrate binding site [chemical binding]; other site 767468004505 trimer interface [polypeptide binding]; other site 767468004506 CoA binding site [chemical binding]; other site 767468004507 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 767468004508 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 767468004509 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 767468004510 putative active site [active] 767468004511 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767468004512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767468004513 NADH(P)-binding; Region: NAD_binding_10; pfam13460 767468004514 NAD(P) binding site [chemical binding]; other site 767468004515 active site 767468004516 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012 767468004517 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468004518 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767468004519 putative Zn2+ binding site [ion binding]; other site 767468004520 putative DNA binding site [nucleotide binding]; other site 767468004521 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767468004522 dimerization interface [polypeptide binding]; other site 767468004523 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 767468004524 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 767468004525 putative NAD(P) binding site [chemical binding]; other site 767468004526 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 767468004527 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767468004528 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767468004529 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 767468004530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767468004531 active site 767468004532 phosphorylation site [posttranslational modification] 767468004533 intermolecular recognition site; other site 767468004534 dimerization interface [polypeptide binding]; other site 767468004535 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 767468004536 DNA binding residues [nucleotide binding] 767468004537 dimerization interface [polypeptide binding]; other site 767468004538 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 767468004539 Histidine kinase; Region: HisKA_3; pfam07730 767468004540 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 767468004541 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767468004542 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767468004543 Walker A/P-loop; other site 767468004544 ATP binding site [chemical binding]; other site 767468004545 Q-loop/lid; other site 767468004546 ABC transporter signature motif; other site 767468004547 Walker B; other site 767468004548 D-loop; other site 767468004549 H-loop/switch region; other site 767468004550 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 767468004551 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468004552 Coenzyme A binding pocket [chemical binding]; other site 767468004553 MarR family; Region: MarR; pfam01047 767468004554 Predicted membrane protein [Function unknown]; Region: COG2364 767468004555 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 767468004556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468004557 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 767468004558 Walker A/P-loop; other site 767468004559 ATP binding site [chemical binding]; other site 767468004560 Q-loop/lid; other site 767468004561 ABC transporter signature motif; other site 767468004562 Walker B; other site 767468004563 D-loop; other site 767468004564 H-loop/switch region; other site 767468004565 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 767468004566 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767468004567 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767468004568 Walker A/P-loop; other site 767468004569 ATP binding site [chemical binding]; other site 767468004570 Q-loop/lid; other site 767468004571 ABC transporter signature motif; other site 767468004572 Walker B; other site 767468004573 D-loop; other site 767468004574 H-loop/switch region; other site 767468004575 Predicted transcriptional regulators [Transcription]; Region: COG1725 767468004576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767468004577 DNA-binding site [nucleotide binding]; DNA binding site 767468004578 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 767468004579 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 767468004580 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 767468004581 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767468004582 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 767468004583 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767468004584 DNA binding residues [nucleotide binding] 767468004585 DNA primase; Validated; Region: dnaG; PRK05667 767468004586 CHC2 zinc finger; Region: zf-CHC2; pfam01807 767468004587 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 767468004588 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 767468004589 active site 767468004590 metal binding site [ion binding]; metal-binding site 767468004591 interdomain interaction site; other site 767468004592 PE-PPE domain; Region: PE-PPE; pfam08237 767468004593 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 767468004594 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 767468004595 dimer interface [polypeptide binding]; other site 767468004596 motif 1; other site 767468004597 active site 767468004598 motif 2; other site 767468004599 motif 3; other site 767468004600 DNA repair protein RecO; Region: reco; TIGR00613 767468004601 Recombination protein O N terminal; Region: RecO_N; pfam11967 767468004602 Recombination protein O C terminal; Region: RecO_C; pfam02565 767468004603 GTPase Era; Reviewed; Region: era; PRK00089 767468004604 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 767468004605 G1 box; other site 767468004606 GTP/Mg2+ binding site [chemical binding]; other site 767468004607 Switch I region; other site 767468004608 G2 box; other site 767468004609 Switch II region; other site 767468004610 G3 box; other site 767468004611 G4 box; other site 767468004612 G5 box; other site 767468004613 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 767468004614 metal-binding heat shock protein; Provisional; Region: PRK00016 767468004615 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 767468004616 PhoH-like protein; Region: PhoH; pfam02562 767468004617 Yqey-like protein; Region: YqeY; pfam09424 767468004618 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 767468004619 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 767468004620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767468004621 NAD(P) binding site [chemical binding]; other site 767468004622 active site 767468004623 endonuclease IV; Provisional; Region: PRK01060 767468004624 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 767468004625 AP (apurinic/apyrimidinic) site pocket; other site 767468004626 DNA interaction; other site 767468004627 Metal-binding active site; metal-binding site 767468004628 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 767468004629 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 767468004630 Uncharacterized conserved protein [Function unknown]; Region: COG1284 767468004631 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 767468004632 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 767468004633 methionine sulfoxide reductase A; Provisional; Region: PRK14054 767468004634 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 767468004635 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 767468004636 dimer interface [polypeptide binding]; other site 767468004637 anticodon binding site; other site 767468004638 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 767468004639 homodimer interface [polypeptide binding]; other site 767468004640 motif 1; other site 767468004641 active site 767468004642 motif 2; other site 767468004643 GAD domain; Region: GAD; pfam02938 767468004644 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 767468004645 active site 767468004646 motif 3; other site 767468004647 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 767468004648 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 767468004649 dimer interface [polypeptide binding]; other site 767468004650 motif 1; other site 767468004651 active site 767468004652 motif 2; other site 767468004653 motif 3; other site 767468004654 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 767468004655 anticodon binding site; other site 767468004656 Bacterial SH3 domain; Region: SH3_3; pfam08239 767468004657 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 767468004658 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 767468004659 active site 767468004660 metal binding site [ion binding]; metal-binding site 767468004661 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 767468004662 Phosphotransferase enzyme family; Region: APH; pfam01636 767468004663 active site 767468004664 ATP binding site [chemical binding]; other site 767468004665 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 767468004666 substrate binding site [chemical binding]; other site 767468004667 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 767468004668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468004669 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 767468004670 putative active site [active] 767468004671 dimerization interface [polypeptide binding]; other site 767468004672 putative tRNAtyr binding site [nucleotide binding]; other site 767468004673 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 767468004674 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767468004675 Zn2+ binding site [ion binding]; other site 767468004676 Mg2+ binding site [ion binding]; other site 767468004677 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 767468004678 synthetase active site [active] 767468004679 NTP binding site [chemical binding]; other site 767468004680 metal binding site [ion binding]; metal-binding site 767468004681 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 767468004682 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 767468004683 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 767468004684 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 767468004685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767468004686 S-adenosylmethionine binding site [chemical binding]; other site 767468004687 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 767468004688 active site 767468004689 DNA binding site [nucleotide binding] 767468004690 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 767468004691 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 767468004692 Int/Topo IB signature motif; other site 767468004693 GTP-binding protein LepA; Provisional; Region: PRK05433 767468004694 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 767468004695 G1 box; other site 767468004696 putative GEF interaction site [polypeptide binding]; other site 767468004697 GTP/Mg2+ binding site [chemical binding]; other site 767468004698 Switch I region; other site 767468004699 G2 box; other site 767468004700 G3 box; other site 767468004701 Switch II region; other site 767468004702 G4 box; other site 767468004703 G5 box; other site 767468004704 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 767468004705 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 767468004706 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 767468004707 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 767468004708 DltD N-terminal region; Region: DltD_N; pfam04915 767468004709 DltD central region; Region: DltD_M; pfam04918 767468004710 DltD C-terminal region; Region: DltD_C; pfam04914 767468004711 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 767468004712 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 767468004713 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 767468004714 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 767468004715 acyl-activating enzyme (AAE) consensus motif; other site 767468004716 AMP binding site [chemical binding]; other site 767468004717 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 767468004718 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767468004719 Beta-lactamase; Region: Beta-lactamase; pfam00144 767468004720 chaperone protein DnaJ; Provisional; Region: PRK14276 767468004721 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 767468004722 HSP70 interaction site [polypeptide binding]; other site 767468004723 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 767468004724 substrate binding site [polypeptide binding]; other site 767468004725 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 767468004726 Zn binding sites [ion binding]; other site 767468004727 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 767468004728 dimer interface [polypeptide binding]; other site 767468004729 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 767468004730 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 767468004731 nucleotide binding site [chemical binding]; other site 767468004732 GrpE; Region: GrpE; pfam01025 767468004733 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 767468004734 dimer interface [polypeptide binding]; other site 767468004735 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 767468004736 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 767468004737 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 767468004738 NLE (NUC135) domain; Region: NLE; pfam08154 767468004739 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 767468004740 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 767468004741 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 767468004742 active site 767468004743 Riboflavin kinase; Region: Flavokinase; smart00904 767468004744 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 767468004745 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 767468004746 RNA binding site [nucleotide binding]; other site 767468004747 active site 767468004748 shikimate kinase; Reviewed; Region: aroK; PRK00131 767468004749 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 767468004750 ADP binding site [chemical binding]; other site 767468004751 magnesium binding site [ion binding]; other site 767468004752 putative shikimate binding site; other site 767468004753 prephenate dehydrogenase; Validated; Region: PRK06545 767468004754 prephenate dehydrogenase; Validated; Region: PRK08507 767468004755 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 767468004756 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 767468004757 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 767468004758 hinge; other site 767468004759 active site 767468004760 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 767468004761 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 767468004762 Tetramer interface [polypeptide binding]; other site 767468004763 active site 767468004764 FMN-binding site [chemical binding]; other site 767468004765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468004766 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468004767 putative substrate translocation pore; other site 767468004768 Chorismate mutase type II; Region: CM_2; pfam01817 767468004769 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 767468004770 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 767468004771 translation initiation factor IF-2; Region: IF-2; TIGR00487 767468004772 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 767468004773 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 767468004774 G1 box; other site 767468004775 putative GEF interaction site [polypeptide binding]; other site 767468004776 GTP/Mg2+ binding site [chemical binding]; other site 767468004777 Switch I region; other site 767468004778 G2 box; other site 767468004779 G3 box; other site 767468004780 Switch II region; other site 767468004781 G4 box; other site 767468004782 G5 box; other site 767468004783 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 767468004784 Translation-initiation factor 2; Region: IF-2; pfam11987 767468004785 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 767468004786 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 767468004787 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 767468004788 putative RNA binding cleft [nucleotide binding]; other site 767468004789 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 767468004790 NusA N-terminal domain; Region: NusA_N; pfam08529 767468004791 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 767468004792 RNA binding site [nucleotide binding]; other site 767468004793 homodimer interface [polypeptide binding]; other site 767468004794 NusA-like KH domain; Region: KH_5; pfam13184 767468004795 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 767468004796 G-X-X-G motif; other site 767468004797 ribosome maturation protein RimP; Reviewed; Region: PRK00092 767468004798 Sm and related proteins; Region: Sm_like; cl00259 767468004799 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 767468004800 putative oligomer interface [polypeptide binding]; other site 767468004801 putative RNA binding site [nucleotide binding]; other site 767468004802 DNA polymerase III PolC; Validated; Region: polC; PRK00448 767468004803 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 767468004804 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 767468004805 generic binding surface II; other site 767468004806 generic binding surface I; other site 767468004807 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 767468004808 active site 767468004809 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 767468004810 active site 767468004811 catalytic site [active] 767468004812 substrate binding site [chemical binding]; other site 767468004813 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 767468004814 prolyl-tRNA synthetase; Provisional; Region: PRK09194 767468004815 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 767468004816 dimer interface [polypeptide binding]; other site 767468004817 motif 1; other site 767468004818 active site 767468004819 motif 2; other site 767468004820 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 767468004821 putative deacylase active site [active] 767468004822 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 767468004823 active site 767468004824 motif 3; other site 767468004825 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 767468004826 anticodon binding site; other site 767468004827 RIP metalloprotease RseP; Region: TIGR00054 767468004828 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 767468004829 active site 767468004830 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 767468004831 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 767468004832 putative substrate binding region [chemical binding]; other site 767468004833 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 767468004834 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 767468004835 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 767468004836 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 767468004837 catalytic residue [active] 767468004838 putative FPP diphosphate binding site; other site 767468004839 putative FPP binding hydrophobic cleft; other site 767468004840 dimer interface [polypeptide binding]; other site 767468004841 putative IPP diphosphate binding site; other site 767468004842 ribosome recycling factor; Reviewed; Region: frr; PRK00083 767468004843 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 767468004844 hinge region; other site 767468004845 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 767468004846 putative nucleotide binding site [chemical binding]; other site 767468004847 uridine monophosphate binding site [chemical binding]; other site 767468004848 homohexameric interface [polypeptide binding]; other site 767468004849 elongation factor Ts; Provisional; Region: tsf; PRK09377 767468004850 UBA/TS-N domain; Region: UBA; pfam00627 767468004851 Elongation factor TS; Region: EF_TS; pfam00889 767468004852 Elongation factor TS; Region: EF_TS; pfam00889 767468004853 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 767468004854 rRNA interaction site [nucleotide binding]; other site 767468004855 S8 interaction site; other site 767468004856 putative laminin-1 binding site; other site 767468004857 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 767468004858 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468004859 motif II; other site 767468004860 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 767468004861 D-lactate dehydrogenase; Validated; Region: PRK08605 767468004862 homodimer interface [polypeptide binding]; other site 767468004863 ligand binding site [chemical binding]; other site 767468004864 NAD binding site [chemical binding]; other site 767468004865 catalytic site [active] 767468004866 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 767468004867 GIY-YIG motif/motif A; other site 767468004868 putative active site [active] 767468004869 putative metal binding site [ion binding]; other site 767468004870 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 767468004871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767468004872 S-adenosylmethionine binding site [chemical binding]; other site 767468004873 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 767468004874 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 767468004875 putative acyl-acceptor binding pocket; other site 767468004876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 767468004877 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 767468004878 LexA repressor; Validated; Region: PRK00215 767468004879 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767468004880 putative DNA binding site [nucleotide binding]; other site 767468004881 putative Zn2+ binding site [ion binding]; other site 767468004882 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 767468004883 Catalytic site [active] 767468004884 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 767468004885 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 767468004886 dimer interface [polypeptide binding]; other site 767468004887 active site 767468004888 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 767468004889 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 767468004890 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 767468004891 Ligand binding site; other site 767468004892 Putative Catalytic site; other site 767468004893 DXD motif; other site 767468004894 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468004895 Transcriptional regulator [Transcription]; Region: LytR; COG1316 767468004896 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767468004897 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 767468004898 Walker A/P-loop; other site 767468004899 ATP binding site [chemical binding]; other site 767468004900 Q-loop/lid; other site 767468004901 ABC transporter signature motif; other site 767468004902 Walker B; other site 767468004903 D-loop; other site 767468004904 H-loop/switch region; other site 767468004905 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 767468004906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468004907 dimer interface [polypeptide binding]; other site 767468004908 conserved gate region; other site 767468004909 ABC-ATPase subunit interface; other site 767468004910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 767468004911 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 767468004912 Bacteriophage holin; Region: Phage_holin_1; cl02344 767468004913 Haemolysin XhlA; Region: XhlA; pfam10779 767468004914 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 767468004915 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 767468004916 active site 767468004917 Bacterial SH3 domain; Region: SH3_5; pfam08460 767468004918 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 767468004919 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767468004920 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 767468004921 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 767468004922 Phage tail protein; Region: Sipho_tail; cl17486 767468004923 Phage-related tail protein [Function unknown]; Region: COG5283 767468004924 NlpC/P60 family; Region: NLPC_P60; pfam00877 767468004925 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767468004926 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 767468004927 N-acetyl-D-glucosamine binding site [chemical binding]; other site 767468004928 catalytic residue [active] 767468004929 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 767468004930 Phage major tail protein; Region: Phage_tail; pfam04630 767468004931 Protein of unknown function (DUF806); Region: DUF806; pfam05657 767468004932 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 767468004933 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 767468004934 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 767468004935 oligomerization interface [polypeptide binding]; other site 767468004936 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 767468004937 Phage capsid family; Region: Phage_capsid; pfam05065 767468004938 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 767468004939 oligomer interface [polypeptide binding]; other site 767468004940 active site residues [active] 767468004941 Phage-related protein [Function unknown]; Region: COG4695 767468004942 Phage portal protein; Region: Phage_portal; pfam04860 767468004943 Protein of unknown function (DUF1056); Region: DUF1056; pfam06341 767468004944 Phage Terminase; Region: Terminase_1; pfam03354 767468004945 Phage terminase, small subunit; Region: Terminase_4; cl01525 767468004946 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 767468004947 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 767468004948 active site 767468004949 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 767468004950 YopX protein; Region: YopX; pfam09643 767468004951 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 767468004952 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 767468004953 cofactor binding site; other site 767468004954 DNA binding site [nucleotide binding] 767468004955 substrate interaction site [chemical binding]; other site 767468004956 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 767468004957 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 767468004958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468004959 Walker A motif; other site 767468004960 ATP binding site [chemical binding]; other site 767468004961 Protein of unknown function (DUF968); Region: DUF968; pfam06147 767468004962 Protein of unknown function (DUF669); Region: DUF669; pfam05037 767468004963 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 767468004964 AAA domain; Region: AAA_24; pfam13479 767468004965 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 767468004966 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 767468004967 ORF6C domain; Region: ORF6C; pfam10552 767468004968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468004969 non-specific DNA binding site [nucleotide binding]; other site 767468004970 salt bridge; other site 767468004971 sequence-specific DNA binding site [nucleotide binding]; other site 767468004972 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468004973 non-specific DNA binding site [nucleotide binding]; other site 767468004974 salt bridge; other site 767468004975 sequence-specific DNA binding site [nucleotide binding]; other site 767468004976 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 767468004977 Catalytic site [active] 767468004978 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 767468004979 Int/Topo IB signature motif; other site 767468004980 Methyltransferase domain; Region: Methyltransf_23; pfam13489 767468004981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 767468004982 hypothetical protein; Provisional; Region: PRK00967 767468004983 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468004984 Helix-turn-helix domain; Region: HTH_20; pfam12840 767468004985 dimerization interface [polypeptide binding]; other site 767468004986 putative DNA binding site [nucleotide binding]; other site 767468004987 putative Zn2+ binding site [ion binding]; other site 767468004988 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767468004989 active site 767468004990 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 767468004991 DHH family; Region: DHH; pfam01368 767468004992 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 767468004993 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 767468004994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767468004995 NAD(P) binding site [chemical binding]; other site 767468004996 active site 767468004997 ribonuclease Z; Region: RNase_Z; TIGR02651 767468004998 GTPase CgtA; Reviewed; Region: obgE; PRK12297 767468004999 GTP1/OBG; Region: GTP1_OBG; pfam01018 767468005000 Obg GTPase; Region: Obg; cd01898 767468005001 G1 box; other site 767468005002 GTP/Mg2+ binding site [chemical binding]; other site 767468005003 Switch I region; other site 767468005004 G2 box; other site 767468005005 G3 box; other site 767468005006 Switch II region; other site 767468005007 G4 box; other site 767468005008 G5 box; other site 767468005009 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 767468005010 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 767468005011 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 767468005012 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 767468005013 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 767468005014 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 767468005015 putative substrate binding site [chemical binding]; other site 767468005016 putative ATP binding site [chemical binding]; other site 767468005017 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 767468005018 active site 767468005019 phosphorylation site [posttranslational modification] 767468005020 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 767468005021 active site 767468005022 P-loop; other site 767468005023 phosphorylation site [posttranslational modification] 767468005024 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 767468005025 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 767468005026 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 767468005027 active site 767468005028 metal binding site [ion binding]; metal-binding site 767468005029 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 767468005030 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 767468005031 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 767468005032 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 767468005033 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 767468005034 active site 767468005035 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 767468005036 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 767468005037 putative ADP-binding pocket [chemical binding]; other site 767468005038 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 767468005039 Bacterial sugar transferase; Region: Bac_transf; pfam02397 767468005040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767468005041 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 767468005042 NAD(P) binding site [chemical binding]; other site 767468005043 active site 767468005044 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 767468005045 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 767468005046 active site 767468005047 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 767468005048 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 767468005049 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 767468005050 Chain length determinant protein; Region: Wzz; cl15801 767468005051 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 767468005052 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 767468005053 GIY-YIG motif/motif A; other site 767468005054 active site 767468005055 catalytic site [active] 767468005056 putative DNA binding site [nucleotide binding]; other site 767468005057 metal binding site [ion binding]; metal-binding site 767468005058 UvrB/uvrC motif; Region: UVR; pfam02151 767468005059 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 767468005060 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 767468005061 DNA binding site [nucleotide binding] 767468005062 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767468005063 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767468005064 Walker A/P-loop; other site 767468005065 ATP binding site [chemical binding]; other site 767468005066 Q-loop/lid; other site 767468005067 ABC transporter signature motif; other site 767468005068 Walker B; other site 767468005069 D-loop; other site 767468005070 H-loop/switch region; other site 767468005071 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767468005072 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767468005073 substrate binding pocket [chemical binding]; other site 767468005074 membrane-bound complex binding site; other site 767468005075 hinge residues; other site 767468005076 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 767468005077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468005078 dimer interface [polypeptide binding]; other site 767468005079 conserved gate region; other site 767468005080 putative PBP binding loops; other site 767468005081 ABC-ATPase subunit interface; other site 767468005082 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 767468005083 putative metal binding site [ion binding]; other site 767468005084 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 767468005085 G1 box; other site 767468005086 GTP/Mg2+ binding site [chemical binding]; other site 767468005087 Switch I region; other site 767468005088 G2 box; other site 767468005089 G3 box; other site 767468005090 Switch II region; other site 767468005091 G4 box; other site 767468005092 G5 box; other site 767468005093 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 767468005094 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 767468005095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468005096 Walker A motif; other site 767468005097 ATP binding site [chemical binding]; other site 767468005098 Walker B motif; other site 767468005099 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 767468005100 trigger factor; Provisional; Region: tig; PRK01490 767468005101 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 767468005102 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 767468005103 elongation factor Tu; Reviewed; Region: PRK12736 767468005104 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 767468005105 G1 box; other site 767468005106 GEF interaction site [polypeptide binding]; other site 767468005107 GTP/Mg2+ binding site [chemical binding]; other site 767468005108 Switch I region; other site 767468005109 G2 box; other site 767468005110 G3 box; other site 767468005111 Switch II region; other site 767468005112 G4 box; other site 767468005113 G5 box; other site 767468005114 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 767468005115 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 767468005116 Antibiotic Binding Site [chemical binding]; other site 767468005117 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 767468005118 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767468005119 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 767468005120 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 767468005121 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 767468005122 dimer interface [polypeptide binding]; other site 767468005123 active site 767468005124 catalytic residue [active] 767468005125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468005126 putative substrate translocation pore; other site 767468005127 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 767468005128 16S/18S rRNA binding site [nucleotide binding]; other site 767468005129 S13e-L30e interaction site [polypeptide binding]; other site 767468005130 25S rRNA binding site [nucleotide binding]; other site 767468005131 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 767468005132 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 767468005133 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 767468005134 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 767468005135 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 767468005136 Competence protein; Region: Competence; pfam03772 767468005137 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 767468005138 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 767468005139 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 767468005140 catalytic motif [active] 767468005141 Zn binding site [ion binding]; other site 767468005142 SLBB domain; Region: SLBB; pfam10531 767468005143 comEA protein; Region: comE; TIGR01259 767468005144 Helix-hairpin-helix motif; Region: HHH; pfam00633 767468005145 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 767468005146 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 767468005147 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 767468005148 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 767468005149 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 767468005150 active site 767468005151 (T/H)XGH motif; other site 767468005152 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 767468005153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767468005154 S-adenosylmethionine binding site [chemical binding]; other site 767468005155 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 767468005156 pyruvate carboxylase; Reviewed; Region: PRK12999 767468005157 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767468005158 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767468005159 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 767468005160 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 767468005161 active site 767468005162 catalytic residues [active] 767468005163 metal binding site [ion binding]; metal-binding site 767468005164 homodimer binding site [polypeptide binding]; other site 767468005165 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 767468005166 carboxyltransferase (CT) interaction site; other site 767468005167 biotinylation site [posttranslational modification]; other site 767468005168 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 767468005169 conserved hypothetical integral membrane protein; Region: TIGR03766 767468005170 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 767468005171 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 767468005172 DXD motif; other site 767468005173 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468005174 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468005175 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 767468005176 exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110 767468005177 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 767468005178 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 767468005179 G1 box; other site 767468005180 putative GEF interaction site [polypeptide binding]; other site 767468005181 GTP/Mg2+ binding site [chemical binding]; other site 767468005182 Switch I region; other site 767468005183 G2 box; other site 767468005184 G3 box; other site 767468005185 Switch II region; other site 767468005186 G4 box; other site 767468005187 G5 box; other site 767468005188 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 767468005189 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 767468005190 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 767468005191 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 767468005192 active site 767468005193 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 767468005194 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 767468005195 substrate binding site [chemical binding]; other site 767468005196 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 767468005197 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767468005198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767468005199 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767468005200 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 767468005201 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 767468005202 E3 interaction surface; other site 767468005203 lipoyl attachment site [posttranslational modification]; other site 767468005204 e3 binding domain; Region: E3_binding; pfam02817 767468005205 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 767468005206 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 767468005207 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 767468005208 alpha subunit interface [polypeptide binding]; other site 767468005209 TPP binding site [chemical binding]; other site 767468005210 heterodimer interface [polypeptide binding]; other site 767468005211 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767468005212 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 767468005213 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 767468005214 TPP-binding site [chemical binding]; other site 767468005215 heterodimer interface [polypeptide binding]; other site 767468005216 tetramer interface [polypeptide binding]; other site 767468005217 phosphorylation loop region [posttranslational modification] 767468005218 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 767468005219 active site 767468005220 catalytic residues [active] 767468005221 metal binding site [ion binding]; metal-binding site 767468005222 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 767468005223 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 767468005224 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767468005225 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 767468005226 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 767468005227 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 767468005228 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767468005229 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767468005230 NlpC/P60 family; Region: NLPC_P60; pfam00877 767468005231 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767468005232 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 767468005233 AAA domain; Region: AAA_30; pfam13604 767468005234 Family description; Region: UvrD_C_2; pfam13538 767468005235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767468005236 binding surface 767468005237 TPR motif; other site 767468005238 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767468005239 catalytic core [active] 767468005240 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 767468005241 WxL domain surface cell wall-binding; Region: WxL; pfam13731 767468005242 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 767468005243 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 767468005244 WxL domain surface cell wall-binding; Region: WxL; pfam13731 767468005245 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 767468005246 TrkA-N domain; Region: TrkA_N; pfam02254 767468005247 TrkA-C domain; Region: TrkA_C; pfam02080 767468005248 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 767468005249 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 767468005250 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 767468005251 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 767468005252 Putative amino acid metabolism; Region: DUF1831; pfam08866 767468005253 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 767468005254 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 767468005255 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767468005256 catalytic residue [active] 767468005257 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 767468005258 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 767468005259 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 767468005260 dimer interface [polypeptide binding]; other site 767468005261 ADP-ribose binding site [chemical binding]; other site 767468005262 active site 767468005263 nudix motif; other site 767468005264 metal binding site [ion binding]; metal-binding site 767468005265 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 767468005266 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 767468005267 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 767468005268 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 767468005269 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767468005270 active site 767468005271 HIGH motif; other site 767468005272 nucleotide binding site [chemical binding]; other site 767468005273 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 767468005274 active site 767468005275 KMSKS motif; other site 767468005276 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 767468005277 tRNA binding surface [nucleotide binding]; other site 767468005278 anticodon binding site; other site 767468005279 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 767468005280 DivIVA protein; Region: DivIVA; pfam05103 767468005281 DivIVA domain; Region: DivI1A_domain; TIGR03544 767468005282 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 767468005283 YGGT family; Region: YGGT; pfam02325 767468005284 Protein of unknown function (DUF552); Region: DUF552; cl00775 767468005285 cell division protein FtsZ; Validated; Region: PRK09330 767468005286 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 767468005287 nucleotide binding site [chemical binding]; other site 767468005288 SulA interaction site; other site 767468005289 cell division protein FtsA; Region: ftsA; TIGR01174 767468005290 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 767468005291 nucleotide binding site [chemical binding]; other site 767468005292 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 767468005293 Cell division protein FtsA; Region: FtsA; pfam14450 767468005294 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 767468005295 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 767468005296 Cell division protein FtsQ; Region: FtsQ; pfam03799 767468005297 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 767468005298 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 767468005299 active site 767468005300 homodimer interface [polypeptide binding]; other site 767468005301 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 767468005302 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 767468005303 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767468005304 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767468005305 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 767468005306 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 767468005307 Mg++ binding site [ion binding]; other site 767468005308 putative catalytic motif [active] 767468005309 putative substrate binding site [chemical binding]; other site 767468005310 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 767468005311 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 767468005312 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767468005313 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 767468005314 cell division protein FtsL; Region: ftsL_broad; TIGR02209 767468005315 MraW methylase family; Region: Methyltransf_5; pfam01795 767468005316 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 767468005317 cell division protein MraZ; Reviewed; Region: PRK00326 767468005318 MraZ protein; Region: MraZ; pfam02381 767468005319 MraZ protein; Region: MraZ; pfam02381 767468005320 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 767468005321 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 767468005322 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 767468005323 Cl binding site [ion binding]; other site 767468005324 oligomer interface [polypeptide binding]; other site 767468005325 putative transposase OrfB; Reviewed; Region: PHA02517 767468005326 HTH-like domain; Region: HTH_21; pfam13276 767468005327 Integrase core domain; Region: rve; pfam00665 767468005328 Integrase core domain; Region: rve_2; pfam13333 767468005329 Winged helix-turn helix; Region: HTH_29; pfam13551 767468005330 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468005331 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767468005332 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468005333 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 767468005334 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 767468005335 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 767468005336 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 767468005337 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 767468005338 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 767468005339 NADH(P)-binding; Region: NAD_binding_10; pfam13460 767468005340 NAD binding site [chemical binding]; other site 767468005341 substrate binding site [chemical binding]; other site 767468005342 putative active site [active] 767468005343 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 767468005344 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 767468005345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767468005346 S-adenosylmethionine binding site [chemical binding]; other site 767468005347 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 767468005348 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 767468005349 Domain of unknown function DUF20; Region: UPF0118; pfam01594 767468005350 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 767468005351 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 767468005352 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 767468005353 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767468005354 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767468005355 active site 767468005356 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 767468005357 ATP-NAD kinase; Region: NAD_kinase; pfam01513 767468005358 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 767468005359 synthetase active site [active] 767468005360 NTP binding site [chemical binding]; other site 767468005361 metal binding site [ion binding]; metal-binding site 767468005362 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 767468005363 catalytic residues [active] 767468005364 oligoendopeptidase F; Region: pepF; TIGR00181 767468005365 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 767468005366 active site 767468005367 Zn binding site [ion binding]; other site 767468005368 Competence protein CoiA-like family; Region: CoiA; cl11541 767468005369 adaptor protein; Provisional; Region: PRK02315 767468005370 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 767468005371 ArsC family; Region: ArsC; pfam03960 767468005372 putative catalytic residues [active] 767468005373 thiol/disulfide switch; other site 767468005374 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 767468005375 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 767468005376 putative transposase OrfB; Reviewed; Region: PHA02517 767468005377 HTH-like domain; Region: HTH_21; pfam13276 767468005378 Integrase core domain; Region: rve; pfam00665 767468005379 Integrase core domain; Region: rve_2; pfam13333 767468005380 Winged helix-turn helix; Region: HTH_29; pfam13551 767468005381 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468005382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767468005383 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468005384 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 767468005385 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 767468005386 RNA binding site [nucleotide binding]; other site 767468005387 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 767468005388 active site 767468005389 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 767468005390 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 767468005391 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 767468005392 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 767468005393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468005394 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 767468005395 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 767468005396 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 767468005397 active site 767468005398 metal binding site [ion binding]; metal-binding site 767468005399 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 767468005400 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 767468005401 putative active site [active] 767468005402 putative metal binding site [ion binding]; other site 767468005403 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 767468005404 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 767468005405 propionate/acetate kinase; Provisional; Region: PRK12379 767468005406 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 767468005407 Methyltransferase domain; Region: Methyltransf_26; pfam13659 767468005408 S-adenosylmethionine binding site [chemical binding]; other site 767468005409 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 767468005410 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 767468005411 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 767468005412 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 767468005413 Type II/IV secretion system protein; Region: T2SE; pfam00437 767468005414 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 767468005415 Walker A motif; other site 767468005416 ATP binding site [chemical binding]; other site 767468005417 Walker B motif; other site 767468005418 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 767468005419 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 767468005420 substrate binding site [chemical binding]; other site 767468005421 dimer interface [polypeptide binding]; other site 767468005422 ATP binding site [chemical binding]; other site 767468005423 hypothetical protein; Validated; Region: PRK00110 767468005424 DsrE/DsrF-like family; Region: DrsE; cl00672 767468005425 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 767468005426 catabolite control protein A; Region: ccpA; TIGR01481 767468005427 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767468005428 DNA binding site [nucleotide binding] 767468005429 domain linker motif; other site 767468005430 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 767468005431 dimerization interface [polypeptide binding]; other site 767468005432 effector binding site; other site 767468005433 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 767468005434 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 767468005435 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 767468005436 active site 767468005437 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 767468005438 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 767468005439 putative dimer interface [polypeptide binding]; other site 767468005440 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 767468005441 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 767468005442 Mechanosensitive ion channel; Region: MS_channel; pfam00924 767468005443 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 767468005444 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 767468005445 metal binding site [ion binding]; metal-binding site 767468005446 putative dimer interface [polypeptide binding]; other site 767468005447 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 767468005448 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 767468005449 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 767468005450 active site 767468005451 trimer interface [polypeptide binding]; other site 767468005452 substrate binding site [chemical binding]; other site 767468005453 CoA binding site [chemical binding]; other site 767468005454 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 767468005455 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 767468005456 active site 767468005457 metal binding site [ion binding]; metal-binding site 767468005458 homotetramer interface [polypeptide binding]; other site 767468005459 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 767468005460 active site 767468005461 dimerization interface [polypeptide binding]; other site 767468005462 glutamate racemase; Provisional; Region: PRK00865 767468005463 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 767468005464 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 767468005465 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 767468005466 catalytic residues [active] 767468005467 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 767468005468 MutS domain III; Region: MutS_III; pfam05192 767468005469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468005470 Walker A/P-loop; other site 767468005471 ATP binding site [chemical binding]; other site 767468005472 Q-loop/lid; other site 767468005473 ABC transporter signature motif; other site 767468005474 Walker B; other site 767468005475 D-loop; other site 767468005476 H-loop/switch region; other site 767468005477 Smr domain; Region: Smr; pfam01713 767468005478 Cell division protein ZapA; Region: ZapA; cl01146 767468005479 hypothetical protein; Provisional; Region: PRK13678 767468005480 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 767468005481 hypothetical protein; Provisional; Region: PRK05473 767468005482 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 767468005483 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 767468005484 motif 1; other site 767468005485 active site 767468005486 motif 2; other site 767468005487 motif 3; other site 767468005488 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 767468005489 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 767468005490 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767468005491 ATP binding site [chemical binding]; other site 767468005492 Mg++ binding site [ion binding]; other site 767468005493 motif III; other site 767468005494 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767468005495 nucleotide binding region [chemical binding]; other site 767468005496 ATP-binding site [chemical binding]; other site 767468005497 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 767468005498 DHH family; Region: DHH; pfam01368 767468005499 DHHA1 domain; Region: DHHA1; pfam02272 767468005500 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 767468005501 active site 767468005502 DNA polymerase IV; Validated; Region: PRK02406 767468005503 DNA binding site [nucleotide binding] 767468005504 Preprotein translocase subunit; Region: YajC; pfam02699 767468005505 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 767468005506 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 767468005507 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 767468005508 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 767468005509 Holliday junction DNA helicase, RuvB subunit; Region: ruvB; TIGR00635 767468005510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468005511 Walker A motif; other site 767468005512 ATP binding site [chemical binding]; other site 767468005513 Walker B motif; other site 767468005514 arginine finger; other site 767468005515 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 767468005516 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 767468005517 RuvA N terminal domain; Region: RuvA_N; pfam01330 767468005518 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 767468005519 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 767468005520 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 767468005521 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468005522 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 767468005523 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 767468005524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 767468005525 ATP binding site [chemical binding]; other site 767468005526 Mg2+ binding site [ion binding]; other site 767468005527 G-X-G motif; other site 767468005528 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 767468005529 ATP binding site [chemical binding]; other site 767468005530 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 767468005531 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 767468005532 MutS domain I; Region: MutS_I; pfam01624 767468005533 MutS domain II; Region: MutS_II; pfam05188 767468005534 MutS domain III; Region: MutS_III; pfam05192 767468005535 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 767468005536 Walker A/P-loop; other site 767468005537 ATP binding site [chemical binding]; other site 767468005538 Q-loop/lid; other site 767468005539 ABC transporter signature motif; other site 767468005540 Walker B; other site 767468005541 D-loop; other site 767468005542 H-loop/switch region; other site 767468005543 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 767468005544 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767468005545 putative active site [active] 767468005546 metal binding site [ion binding]; metal-binding site 767468005547 homodimer binding site [polypeptide binding]; other site 767468005548 ribonuclease Y; Region: RNase_Y; TIGR03319 767468005549 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767468005550 Zn2+ binding site [ion binding]; other site 767468005551 Mg2+ binding site [ion binding]; other site 767468005552 recombinase A; Provisional; Region: recA; PRK09354 767468005553 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 767468005554 hexamer interface [polypeptide binding]; other site 767468005555 Walker A motif; other site 767468005556 ATP binding site [chemical binding]; other site 767468005557 Walker B motif; other site 767468005558 competence damage-inducible protein A; Provisional; Region: PRK00549 767468005559 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 767468005560 putative MPT binding site; other site 767468005561 Competence-damaged protein; Region: CinA; pfam02464 767468005562 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 767468005563 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 767468005564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468005565 non-specific DNA binding site [nucleotide binding]; other site 767468005566 salt bridge; other site 767468005567 sequence-specific DNA binding site [nucleotide binding]; other site 767468005568 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 767468005569 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 767468005570 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 767468005571 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 767468005572 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 767468005573 aspartate kinase; Reviewed; Region: PRK09034 767468005574 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 767468005575 putative catalytic residues [active] 767468005576 putative nucleotide binding site [chemical binding]; other site 767468005577 putative aspartate binding site [chemical binding]; other site 767468005578 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 767468005579 allosteric regulatory residue; other site 767468005580 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 767468005581 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767468005582 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767468005583 substrate binding pocket [chemical binding]; other site 767468005584 membrane-bound complex binding site; other site 767468005585 hinge residues; other site 767468005586 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767468005587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468005588 Walker A/P-loop; other site 767468005589 ATP binding site [chemical binding]; other site 767468005590 Q-loop/lid; other site 767468005591 ABC transporter signature motif; other site 767468005592 Walker B; other site 767468005593 D-loop; other site 767468005594 H-loop/switch region; other site 767468005595 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 767468005596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468005597 dimer interface [polypeptide binding]; other site 767468005598 conserved gate region; other site 767468005599 putative PBP binding loops; other site 767468005600 ABC-ATPase subunit interface; other site 767468005601 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 767468005602 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 767468005603 Switch I; other site 767468005604 Switch II; other site 767468005605 septum formation inhibitor; Reviewed; Region: minC; PRK00513 767468005606 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 767468005607 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 767468005608 rod shape-determining protein MreC; Provisional; Region: PRK13922 767468005609 rod shape-determining protein MreC; Region: MreC; pfam04085 767468005610 rod shape-determining protein MreB; Provisional; Region: PRK13927 767468005611 MreB and similar proteins; Region: MreB_like; cd10225 767468005612 nucleotide binding site [chemical binding]; other site 767468005613 Mg binding site [ion binding]; other site 767468005614 putative protofilament interaction site [polypeptide binding]; other site 767468005615 RodZ interaction site [polypeptide binding]; other site 767468005616 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 767468005617 MPN+ (JAMM) motif; other site 767468005618 Zinc-binding site [ion binding]; other site 767468005619 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 767468005620 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767468005621 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767468005622 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 767468005623 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767468005624 active site 767468005625 HIGH motif; other site 767468005626 nucleotide binding site [chemical binding]; other site 767468005627 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 767468005628 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 767468005629 active site 767468005630 KMSKS motif; other site 767468005631 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 767468005632 tRNA binding surface [nucleotide binding]; other site 767468005633 anticodon binding site; other site 767468005634 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 767468005635 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 767468005636 dimer interface [polypeptide binding]; other site 767468005637 catalytic triad [active] 767468005638 peroxidatic and resolving cysteines [active] 767468005639 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 767468005640 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 767468005641 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 767468005642 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 767468005643 Ligand Binding Site [chemical binding]; other site 767468005644 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 767468005645 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 767468005646 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767468005647 catalytic residue [active] 767468005648 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 767468005649 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 767468005650 GAF domain; Region: GAF_2; pfam13185 767468005651 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 767468005652 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 767468005653 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767468005654 RNA binding surface [nucleotide binding]; other site 767468005655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 767468005656 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 767468005657 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 767468005658 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 767468005659 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767468005660 dimerization interface [polypeptide binding]; other site 767468005661 putative DNA binding site [nucleotide binding]; other site 767468005662 putative Zn2+ binding site [ion binding]; other site 767468005663 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 767468005664 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 767468005665 recombination factor protein RarA; Reviewed; Region: PRK13342 767468005666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468005667 Walker A motif; other site 767468005668 ATP binding site [chemical binding]; other site 767468005669 Walker B motif; other site 767468005670 arginine finger; other site 767468005671 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 767468005672 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767468005673 Ligand Binding Site [chemical binding]; other site 767468005674 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 767468005675 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 767468005676 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468005677 non-specific DNA binding site [nucleotide binding]; other site 767468005678 salt bridge; other site 767468005679 sequence-specific DNA binding site [nucleotide binding]; other site 767468005680 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 767468005681 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 767468005682 putative active site [active] 767468005683 catalytic site [active] 767468005684 putative metal binding site [ion binding]; other site 767468005685 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 767468005686 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 767468005687 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 767468005688 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 767468005689 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 767468005690 putative NAD(P) binding site [chemical binding]; other site 767468005691 dimer interface [polypeptide binding]; other site 767468005692 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 767468005693 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 767468005694 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767468005695 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 767468005696 NAD binding site [chemical binding]; other site 767468005697 dimer interface [polypeptide binding]; other site 767468005698 substrate binding site [chemical binding]; other site 767468005699 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 767468005700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468005701 dimer interface [polypeptide binding]; other site 767468005702 conserved gate region; other site 767468005703 ABC-ATPase subunit interface; other site 767468005704 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 767468005705 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 767468005706 Walker A/P-loop; other site 767468005707 ATP binding site [chemical binding]; other site 767468005708 Q-loop/lid; other site 767468005709 ABC transporter signature motif; other site 767468005710 Walker B; other site 767468005711 D-loop; other site 767468005712 H-loop/switch region; other site 767468005713 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 767468005714 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 767468005715 lipoyl attachment site [posttranslational modification]; other site 767468005716 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 767468005717 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 767468005718 hypothetical protein; Validated; Region: PRK00041 767468005719 rod shape-determining protein MreB; Provisional; Region: PRK13930 767468005720 MreB and similar proteins; Region: MreB_like; cd10225 767468005721 nucleotide binding site [chemical binding]; other site 767468005722 Mg binding site [ion binding]; other site 767468005723 putative protofilament interaction site [polypeptide binding]; other site 767468005724 RodZ interaction site [polypeptide binding]; other site 767468005725 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 767468005726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 767468005727 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 767468005728 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 767468005729 hinge; other site 767468005730 active site 767468005731 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 767468005732 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 767468005733 gamma subunit interface [polypeptide binding]; other site 767468005734 epsilon subunit interface [polypeptide binding]; other site 767468005735 LBP interface [polypeptide binding]; other site 767468005736 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 767468005737 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 767468005738 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 767468005739 alpha subunit interaction interface [polypeptide binding]; other site 767468005740 Walker A motif; other site 767468005741 ATP binding site [chemical binding]; other site 767468005742 Walker B motif; other site 767468005743 inhibitor binding site; inhibition site 767468005744 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 767468005745 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 767468005746 core domain interface [polypeptide binding]; other site 767468005747 delta subunit interface [polypeptide binding]; other site 767468005748 epsilon subunit interface [polypeptide binding]; other site 767468005749 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 767468005750 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 767468005751 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 767468005752 beta subunit interaction interface [polypeptide binding]; other site 767468005753 Walker A motif; other site 767468005754 ATP binding site [chemical binding]; other site 767468005755 Walker B motif; other site 767468005756 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 767468005757 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 767468005758 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 767468005759 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 767468005760 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 767468005761 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 767468005762 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 767468005763 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 767468005764 uracil transporter; Provisional; Region: PRK10720 767468005765 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767468005766 MULE transposase domain; Region: MULE; pfam10551 767468005767 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767468005768 active site 767468005769 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 767468005770 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 767468005771 dimer interface [polypeptide binding]; other site 767468005772 active site 767468005773 glycine-pyridoxal phosphate binding site [chemical binding]; other site 767468005774 folate binding site [chemical binding]; other site 767468005775 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 767468005776 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 767468005777 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 767468005778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767468005779 S-adenosylmethionine binding site [chemical binding]; other site 767468005780 peptide chain release factor 1; Validated; Region: prfA; PRK00591 767468005781 This domain is found in peptide chain release factors; Region: PCRF; smart00937 767468005782 RF-1 domain; Region: RF-1; pfam00472 767468005783 thymidine kinase; Provisional; Region: PRK04296 767468005784 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 767468005785 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767468005786 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 767468005787 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 767468005788 catalytic triad [active] 767468005789 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 767468005790 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 767468005791 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767468005792 Beta-lactamase; Region: Beta-lactamase; pfam00144 767468005793 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 767468005794 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 767468005795 homodimer interface [polypeptide binding]; other site 767468005796 substrate-cofactor binding pocket; other site 767468005797 catalytic residue [active] 767468005798 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767468005799 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767468005800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468005801 Walker A/P-loop; other site 767468005802 ATP binding site [chemical binding]; other site 767468005803 Q-loop/lid; other site 767468005804 ABC transporter signature motif; other site 767468005805 Walker B; other site 767468005806 D-loop; other site 767468005807 H-loop/switch region; other site 767468005808 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767468005809 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767468005810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468005811 Walker A/P-loop; other site 767468005812 ATP binding site [chemical binding]; other site 767468005813 Q-loop/lid; other site 767468005814 ABC transporter signature motif; other site 767468005815 Walker B; other site 767468005816 D-loop; other site 767468005817 H-loop/switch region; other site 767468005818 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 767468005819 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 767468005820 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 767468005821 putative active site [active] 767468005822 putative metal binding site [ion binding]; other site 767468005823 Abi-like protein; Region: Abi_2; pfam07751 767468005824 Haemolysin XhlA; Region: XhlA; pfam10779 767468005825 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 767468005826 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 767468005827 active site 767468005828 Bacterial SH3 domain; Region: SH3_5; pfam08460 767468005829 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 767468005830 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767468005831 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 767468005832 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 767468005833 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 767468005834 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 767468005835 active site 767468005836 catalytic triad [active] 767468005837 oxyanion hole [active] 767468005838 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 767468005839 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 767468005840 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 767468005841 active site 767468005842 Phage tail protein; Region: Sipho_tail; cl17486 767468005843 Phage-related tail protein [Function unknown]; Region: COG5283 767468005844 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 767468005845 Phage protein; Region: DUF3647; pfam12363 767468005846 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 767468005847 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 767468005848 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 767468005849 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 767468005850 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 767468005851 Phage terminase large subunit; Region: Terminase_3; cl12054 767468005852 Terminase-like family; Region: Terminase_6; pfam03237 767468005853 Terminase small subunit; Region: Terminase_2; pfam03592 767468005854 Uncharacterized conserved protein [Function unknown]; Region: COG4933 767468005855 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 767468005856 YopX protein; Region: YopX; pfam09643 767468005857 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 767468005858 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 767468005859 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 767468005860 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 767468005861 sequence-specific DNA binding site [nucleotide binding]; other site 767468005862 salt bridge; other site 767468005863 Domain of unknown function (DUF771); Region: DUF771; cl09962 767468005864 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767468005865 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468005866 non-specific DNA binding site [nucleotide binding]; other site 767468005867 salt bridge; other site 767468005868 sequence-specific DNA binding site [nucleotide binding]; other site 767468005869 Domain of unknown function (DUF955); Region: DUF955; pfam06114 767468005870 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 767468005871 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767468005872 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 767468005873 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 767468005874 Int/Topo IB signature motif; other site 767468005875 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 767468005876 oligomerization interface [polypeptide binding]; other site 767468005877 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 767468005878 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 767468005879 Phage capsid family; Region: Phage_capsid; pfam05065 767468005880 Phage-related protein [Function unknown]; Region: COG4695; cl01923 767468005881 Phage Terminase; Region: Terminase_1; pfam03354 767468005882 Phage terminase, small subunit; Region: Terminase_4; pfam05119 767468005883 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 767468005884 active site 767468005885 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 767468005886 Virulence-associated protein E; Region: VirE; pfam05272 767468005887 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 767468005888 polymerase nucleotide-binding site; other site 767468005889 DNA-binding residues [nucleotide binding]; DNA binding site 767468005890 nucleotide binding site [chemical binding]; other site 767468005891 primase nucleotide-binding site [nucleotide binding]; other site 767468005892 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 767468005893 Helix-turn-helix domain; Region: HTH_17; pfam12728 767468005894 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767468005895 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468005896 non-specific DNA binding site [nucleotide binding]; other site 767468005897 salt bridge; other site 767468005898 sequence-specific DNA binding site [nucleotide binding]; other site 767468005899 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 767468005900 Int/Topo IB signature motif; other site 767468005901 Transcriptional regulators [Transcription]; Region: MarR; COG1846 767468005902 MarR family; Region: MarR_2; pfam12802 767468005903 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 767468005904 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 767468005905 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 767468005906 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 767468005907 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 767468005908 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 767468005909 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767468005910 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767468005911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468005912 Walker A/P-loop; other site 767468005913 ATP binding site [chemical binding]; other site 767468005914 Q-loop/lid; other site 767468005915 ABC transporter signature motif; other site 767468005916 Walker B; other site 767468005917 D-loop; other site 767468005918 H-loop/switch region; other site 767468005919 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767468005920 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767468005921 Walker A/P-loop; other site 767468005922 ATP binding site [chemical binding]; other site 767468005923 Q-loop/lid; other site 767468005924 ABC transporter signature motif; other site 767468005925 Walker B; other site 767468005926 D-loop; other site 767468005927 H-loop/switch region; other site 767468005928 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767468005929 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 767468005930 FtsX-like permease family; Region: FtsX; pfam02687 767468005931 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 767468005932 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 767468005933 active site 767468005934 dimer interface [polypeptide binding]; other site 767468005935 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 767468005936 dimer interface [polypeptide binding]; other site 767468005937 active site 767468005938 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468005939 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468005940 Integrase core domain; Region: rve; pfam00665 767468005941 Sugar transport protein; Region: Sugar_transport; pfam06800 767468005942 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 767468005943 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 767468005944 putative RNA binding site [nucleotide binding]; other site 767468005945 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767468005946 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767468005947 dimerization interface [polypeptide binding]; other site 767468005948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767468005949 dimer interface [polypeptide binding]; other site 767468005950 phosphorylation site [posttranslational modification] 767468005951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767468005952 ATP binding site [chemical binding]; other site 767468005953 Mg2+ binding site [ion binding]; other site 767468005954 G-X-G motif; other site 767468005955 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767468005956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767468005957 active site 767468005958 phosphorylation site [posttranslational modification] 767468005959 intermolecular recognition site; other site 767468005960 dimerization interface [polypeptide binding]; other site 767468005961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767468005962 DNA binding site [nucleotide binding] 767468005963 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 767468005964 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 767468005965 EamA-like transporter family; Region: EamA; pfam00892 767468005966 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 767468005967 EamA-like transporter family; Region: EamA; pfam00892 767468005968 Winged helix-turn helix; Region: HTH_29; pfam13551 767468005969 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468005970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767468005971 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468005972 putative transposase OrfB; Reviewed; Region: PHA02517 767468005973 HTH-like domain; Region: HTH_21; pfam13276 767468005974 Integrase core domain; Region: rve; pfam00665 767468005975 Integrase core domain; Region: rve_2; pfam13333 767468005976 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 767468005977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468005978 benzoate transport; Region: 2A0115; TIGR00895 767468005979 putative substrate translocation pore; other site 767468005980 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 767468005981 nudix motif; other site 767468005982 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 767468005983 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767468005984 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767468005985 NlpC/P60 family; Region: NLPC_P60; pfam00877 767468005986 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 767468005987 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767468005988 putative DNA binding site [nucleotide binding]; other site 767468005989 putative Zn2+ binding site [ion binding]; other site 767468005990 AsnC family; Region: AsnC_trans_reg; pfam01037 767468005991 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 767468005992 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 767468005993 metal binding site [ion binding]; metal-binding site 767468005994 active site 767468005995 I-site; other site 767468005996 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468005997 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468005998 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 767468005999 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 767468006000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468006001 Walker A/P-loop; other site 767468006002 ATP binding site [chemical binding]; other site 767468006003 Q-loop/lid; other site 767468006004 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767468006005 ABC transporter signature motif; other site 767468006006 Walker B; other site 767468006007 D-loop; other site 767468006008 ABC transporter; Region: ABC_tran_2; pfam12848 767468006009 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767468006010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468006011 Coenzyme A binding pocket [chemical binding]; other site 767468006012 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 767468006013 dimer interface [polypeptide binding]; other site 767468006014 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 767468006015 metal binding site [ion binding]; metal-binding site 767468006016 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 767468006017 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767468006018 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767468006019 active site turn [active] 767468006020 phosphorylation site [posttranslational modification] 767468006021 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 767468006022 HPr interaction site; other site 767468006023 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767468006024 active site 767468006025 phosphorylation site [posttranslational modification] 767468006026 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 767468006027 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 767468006028 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 767468006029 EDD domain protein, DegV family; Region: DegV; TIGR00762 767468006030 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767468006031 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 767468006032 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 767468006033 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 767468006034 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 767468006035 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 767468006036 homodimer interface [polypeptide binding]; other site 767468006037 substrate-cofactor binding pocket; other site 767468006038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468006039 catalytic residue [active] 767468006040 Homoserine O-succinyltransferase; Region: HTS; pfam04204 767468006041 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 767468006042 proposed active site lysine [active] 767468006043 conserved cys residue [active] 767468006044 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 767468006045 zinc binding site [ion binding]; other site 767468006046 putative ligand binding site [chemical binding]; other site 767468006047 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 767468006048 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 767468006049 TM-ABC transporter signature motif; other site 767468006050 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 767468006051 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468006052 Walker A/P-loop; other site 767468006053 ATP binding site [chemical binding]; other site 767468006054 Q-loop/lid; other site 767468006055 ABC transporter signature motif; other site 767468006056 Walker B; other site 767468006057 D-loop; other site 767468006058 H-loop/switch region; other site 767468006059 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 767468006060 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767468006061 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767468006062 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767468006063 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 767468006064 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 767468006065 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 767468006066 maltose O-acetyltransferase; Provisional; Region: PRK10092 767468006067 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 767468006068 active site 767468006069 substrate binding site [chemical binding]; other site 767468006070 trimer interface [polypeptide binding]; other site 767468006071 CoA binding site [chemical binding]; other site 767468006072 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 767468006073 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767468006074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468006075 homodimer interface [polypeptide binding]; other site 767468006076 catalytic residue [active] 767468006077 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 767468006078 metal binding site [ion binding]; metal-binding site 767468006079 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; pfam01502 767468006080 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 767468006081 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 767468006082 substrate binding site [chemical binding]; other site 767468006083 glutamase interaction surface [polypeptide binding]; other site 767468006084 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 767468006085 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 767468006086 catalytic residues [active] 767468006087 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 767468006088 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 767468006089 putative active site [active] 767468006090 oxyanion strand; other site 767468006091 catalytic triad [active] 767468006092 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 767468006093 putative active site pocket [active] 767468006094 4-fold oligomerization interface [polypeptide binding]; other site 767468006095 metal binding residues [ion binding]; metal-binding site 767468006096 3-fold/trimer interface [polypeptide binding]; other site 767468006097 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 767468006098 histidinol dehydrogenase; Region: hisD; TIGR00069 767468006099 NAD binding site [chemical binding]; other site 767468006100 dimerization interface [polypeptide binding]; other site 767468006101 product binding site; other site 767468006102 substrate binding site [chemical binding]; other site 767468006103 zinc binding site [ion binding]; other site 767468006104 catalytic residues [active] 767468006105 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 767468006106 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 767468006107 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 767468006108 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 767468006109 dimer interface [polypeptide binding]; other site 767468006110 motif 1; other site 767468006111 active site 767468006112 motif 2; other site 767468006113 motif 3; other site 767468006114 histidinol-phosphatase; Reviewed; Region: PRK08123 767468006115 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 767468006116 active site 767468006117 dimer interface [polypeptide binding]; other site 767468006118 VanZ like family; Region: VanZ; pfam04892 767468006119 RDD family; Region: RDD; pfam06271 767468006120 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 767468006121 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 767468006122 Cl binding site [ion binding]; other site 767468006123 oligomer interface [polypeptide binding]; other site 767468006124 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 767468006125 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 767468006126 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 767468006127 DNA binding residues [nucleotide binding] 767468006128 putative dimer interface [polypeptide binding]; other site 767468006129 short chain dehydrogenase; Provisional; Region: PRK06180 767468006130 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 767468006131 NADP binding site [chemical binding]; other site 767468006132 active site 767468006133 steroid binding site; other site 767468006134 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 767468006135 hydrophobic ligand binding site; other site 767468006136 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 767468006137 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 767468006138 Peptidase M15; Region: Peptidase_M15_3; cl01194 767468006139 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 767468006140 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 767468006141 active site 767468006142 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 767468006143 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 767468006144 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468006145 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 767468006146 Coenzyme A binding pocket [chemical binding]; other site 767468006147 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 767468006148 Sulfatase; Region: Sulfatase; pfam00884 767468006149 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 767468006150 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 767468006151 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 767468006152 putative active site [active] 767468006153 catalytic site [active] 767468006154 putative metal binding site [ion binding]; other site 767468006155 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 767468006156 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767468006157 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767468006158 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767468006159 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 767468006160 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 767468006161 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 767468006162 dimer interface [polypeptide binding]; other site 767468006163 FMN binding site [chemical binding]; other site 767468006164 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 767468006165 active site 767468006166 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 767468006167 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 767468006168 RNA/DNA hybrid binding site [nucleotide binding]; other site 767468006169 active site 767468006170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468006171 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767468006172 active site 767468006173 motif I; other site 767468006174 motif II; other site 767468006175 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468006176 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767468006177 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767468006178 DNA binding site [nucleotide binding] 767468006179 domain linker motif; other site 767468006180 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 767468006181 putative dimerization interface [polypeptide binding]; other site 767468006182 putative ligand binding site [chemical binding]; other site 767468006183 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 767468006184 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 767468006185 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 767468006186 putative active site [active] 767468006187 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 767468006188 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767468006189 putative oxidoreductase; Provisional; Region: PRK10206 767468006190 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767468006191 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 767468006192 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 767468006193 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 767468006194 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 767468006195 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 767468006196 TPP-binding site; other site 767468006197 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 767468006198 PYR/PP interface [polypeptide binding]; other site 767468006199 dimer interface [polypeptide binding]; other site 767468006200 TPP binding site [chemical binding]; other site 767468006201 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767468006202 Isochorismatase family; Region: Isochorismatase; pfam00857 767468006203 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 767468006204 catalytic triad [active] 767468006205 conserved cis-peptide bond; other site 767468006206 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 767468006207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468006208 Walker A/P-loop; other site 767468006209 ATP binding site [chemical binding]; other site 767468006210 Q-loop/lid; other site 767468006211 ABC transporter signature motif; other site 767468006212 Walker B; other site 767468006213 D-loop; other site 767468006214 H-loop/switch region; other site 767468006215 Predicted transcriptional regulators [Transcription]; Region: COG1725 767468006216 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767468006217 DNA-binding site [nucleotide binding]; DNA binding site 767468006218 Enterocin A Immunity; Region: EntA_Immun; pfam08951 767468006219 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 767468006220 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 767468006221 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 767468006222 active site 767468006223 Zn binding site [ion binding]; other site 767468006224 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767468006225 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468006226 non-specific DNA binding site [nucleotide binding]; other site 767468006227 salt bridge; other site 767468006228 sequence-specific DNA binding site [nucleotide binding]; other site 767468006229 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 767468006230 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 767468006231 PYR/PP interface [polypeptide binding]; other site 767468006232 dimer interface [polypeptide binding]; other site 767468006233 tetramer interface [polypeptide binding]; other site 767468006234 TPP binding site [chemical binding]; other site 767468006235 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 767468006236 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 767468006237 TPP-binding site [chemical binding]; other site 767468006238 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 767468006239 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767468006240 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 767468006241 catalytic residues [active] 767468006242 cystathionine gamma-synthase; Reviewed; Region: PRK08247 767468006243 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 767468006244 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767468006245 catalytic residue [active] 767468006246 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 767468006247 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 767468006248 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 767468006249 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 767468006250 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 767468006251 Bacterial SH3 domain; Region: SH3_5; pfam08460 767468006252 Bacterial SH3 domain; Region: SH3_5; pfam08460 767468006253 Bacterial SH3 domain; Region: SH3_5; pfam08460 767468006254 Bacterial SH3 domain; Region: SH3_5; pfam08460 767468006255 Bacterial SH3 domain; Region: SH3_5; pfam08460 767468006256 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767468006257 Ligand Binding Site [chemical binding]; other site 767468006258 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767468006259 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767468006260 active site 767468006261 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468006262 non-specific DNA binding site [nucleotide binding]; other site 767468006263 salt bridge; other site 767468006264 sequence-specific DNA binding site [nucleotide binding]; other site 767468006265 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767468006266 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 767468006267 putative ADP-binding pocket [chemical binding]; other site 767468006268 putative phosphoketolase; Provisional; Region: PRK05261 767468006269 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 767468006270 TPP-binding site; other site 767468006271 XFP C-terminal domain; Region: XFP_C; pfam09363 767468006272 Predicted esterase [General function prediction only]; Region: COG0627 767468006273 S-formylglutathione hydrolase; Region: PLN02442 767468006274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767468006275 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 767468006276 DNA-binding site [nucleotide binding]; DNA binding site 767468006277 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 767468006278 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 767468006279 putative deacylase active site [active] 767468006280 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 767468006281 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 767468006282 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 767468006283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767468006284 active site 767468006285 phosphorylation site [posttranslational modification] 767468006286 intermolecular recognition site; other site 767468006287 dimerization interface [polypeptide binding]; other site 767468006288 LytTr DNA-binding domain; Region: LytTR; pfam04397 767468006289 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 767468006290 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 767468006291 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 767468006292 putative dimer interface [polypeptide binding]; other site 767468006293 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 767468006294 Domain of unknown function DUF21; Region: DUF21; pfam01595 767468006295 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 767468006296 Transporter associated domain; Region: CorC_HlyC; smart01091 767468006297 flavoprotein NrdI; Provisional; Region: PRK02551 767468006298 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 767468006299 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 767468006300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468006301 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468006302 putative substrate translocation pore; other site 767468006303 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 767468006304 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 767468006305 DNA binding residues [nucleotide binding] 767468006306 putative dimer interface [polypeptide binding]; other site 767468006307 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 767468006308 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 767468006309 SdpI/YhfL protein family; Region: SdpI; pfam13630 767468006310 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 767468006311 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 767468006312 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 767468006313 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 767468006314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767468006315 DNA-binding site [nucleotide binding]; DNA binding site 767468006316 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767468006317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468006318 homodimer interface [polypeptide binding]; other site 767468006319 aromatic amino acid aminotransferase; Validated; Region: PRK07309 767468006320 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767468006321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468006322 homodimer interface [polypeptide binding]; other site 767468006323 catalytic residue [active] 767468006324 dihydrodipicolinate synthase; Region: dapA; TIGR00674 767468006325 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 767468006326 dimer interface [polypeptide binding]; other site 767468006327 active site 767468006328 catalytic residue [active] 767468006329 hypothetical protein; Provisional; Region: PRK10621 767468006330 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 767468006331 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468006332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767468006333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 767468006334 dimerization interface [polypeptide binding]; other site 767468006335 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 767468006336 NADH(P)-binding; Region: NAD_binding_10; pfam13460 767468006337 NAD(P) binding site [chemical binding]; other site 767468006338 putative active site [active] 767468006339 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 767468006340 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 767468006341 Part of AAA domain; Region: AAA_19; pfam13245 767468006342 Family description; Region: UvrD_C_2; pfam13538 767468006343 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 767468006344 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 767468006345 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 767468006346 Protein of unknown function, DUF606; Region: DUF606; pfam04657 767468006347 Protein of unknown function, DUF606; Region: DUF606; pfam04657 767468006348 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767468006349 active site 767468006350 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 767468006351 active site 767468006352 dimer interface [polypeptide binding]; other site 767468006353 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 767468006354 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 767468006355 heterodimer interface [polypeptide binding]; other site 767468006356 active site 767468006357 FMN binding site [chemical binding]; other site 767468006358 homodimer interface [polypeptide binding]; other site 767468006359 substrate binding site [chemical binding]; other site 767468006360 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 767468006361 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767468006362 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 767468006363 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 767468006364 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767468006365 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767468006366 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 767468006367 IMP binding site; other site 767468006368 dimer interface [polypeptide binding]; other site 767468006369 interdomain contacts; other site 767468006370 partial ornithine binding site; other site 767468006371 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 767468006372 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 767468006373 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 767468006374 catalytic site [active] 767468006375 subunit interface [polypeptide binding]; other site 767468006376 dihydroorotase; Validated; Region: pyrC; PRK09357 767468006377 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767468006378 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 767468006379 active site 767468006380 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 767468006381 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 767468006382 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 767468006383 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 767468006384 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767468006385 active site 767468006386 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 767468006387 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 767468006388 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 767468006389 xanthine permease; Region: pbuX; TIGR03173 767468006390 Sulfate transporter family; Region: Sulfate_transp; pfam00916 767468006391 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 767468006392 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 767468006393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767468006394 NAD(P) binding site [chemical binding]; other site 767468006395 active site 767468006396 EAL domain; Region: EAL; pfam00563 767468006397 N-glycosyltransferase; Provisional; Region: PRK11204 767468006398 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 767468006399 DXD motif; other site 767468006400 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 767468006401 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 767468006402 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 767468006403 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 767468006404 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 767468006405 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 767468006406 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 767468006407 purine monophosphate binding site [chemical binding]; other site 767468006408 dimer interface [polypeptide binding]; other site 767468006409 putative catalytic residues [active] 767468006410 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 767468006411 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 767468006412 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 767468006413 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 767468006414 active site 767468006415 substrate binding site [chemical binding]; other site 767468006416 cosubstrate binding site; other site 767468006417 catalytic site [active] 767468006418 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 767468006419 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 767468006420 dimerization interface [polypeptide binding]; other site 767468006421 putative ATP binding site [chemical binding]; other site 767468006422 amidophosphoribosyltransferase; Provisional; Region: PRK07272 767468006423 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 767468006424 active site 767468006425 tetramer interface [polypeptide binding]; other site 767468006426 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767468006427 active site 767468006428 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 767468006429 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 767468006430 dimerization interface [polypeptide binding]; other site 767468006431 ATP binding site [chemical binding]; other site 767468006432 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 767468006433 dimerization interface [polypeptide binding]; other site 767468006434 ATP binding site [chemical binding]; other site 767468006435 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 767468006436 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 767468006437 putative active site [active] 767468006438 catalytic triad [active] 767468006439 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 767468006440 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 767468006441 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 767468006442 ATP binding site [chemical binding]; other site 767468006443 active site 767468006444 substrate binding site [chemical binding]; other site 767468006445 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 767468006446 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 767468006447 NAD binding site [chemical binding]; other site 767468006448 ATP-grasp domain; Region: ATP-grasp; pfam02222 767468006449 AIR carboxylase; Region: AIRC; pfam00731 767468006450 Predicted flavoprotein [General function prediction only]; Region: COG0431 767468006451 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767468006452 PAS domain; Region: PAS_10; pfam13596 767468006453 Predicted flavoprotein [General function prediction only]; Region: COG0431 767468006454 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767468006455 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 767468006456 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 767468006457 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 767468006458 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 767468006459 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 767468006460 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 767468006461 active site 767468006462 zinc binding site [ion binding]; other site 767468006463 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767468006464 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 767468006465 active site 767468006466 homotetramer interface [polypeptide binding]; other site 767468006467 homodimer interface [polypeptide binding]; other site 767468006468 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767468006469 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767468006470 Walker A/P-loop; other site 767468006471 ATP binding site [chemical binding]; other site 767468006472 Q-loop/lid; other site 767468006473 ABC transporter signature motif; other site 767468006474 Walker B; other site 767468006475 D-loop; other site 767468006476 H-loop/switch region; other site 767468006477 FtsX-like permease family; Region: FtsX; pfam02687 767468006478 Predicted transcriptional regulators [Transcription]; Region: COG1725 767468006479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767468006480 DNA-binding site [nucleotide binding]; DNA binding site 767468006481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468006482 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767468006483 Walker A/P-loop; other site 767468006484 ATP binding site [chemical binding]; other site 767468006485 Q-loop/lid; other site 767468006486 ABC transporter signature motif; other site 767468006487 Walker B; other site 767468006488 D-loop; other site 767468006489 H-loop/switch region; other site 767468006490 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767468006491 Ligand Binding Site [chemical binding]; other site 767468006492 Predicted membrane protein [Function unknown]; Region: COG2246 767468006493 GtrA-like protein; Region: GtrA; pfam04138 767468006494 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 767468006495 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767468006496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468006497 homodimer interface [polypeptide binding]; other site 767468006498 catalytic residue [active] 767468006499 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 767468006500 homodimer interface [polypeptide binding]; other site 767468006501 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 767468006502 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 767468006503 active site 767468006504 homodimer interface [polypeptide binding]; other site 767468006505 catalytic site [active] 767468006506 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 767468006507 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 767468006508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468006509 catalytic residue [active] 767468006510 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767468006511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468006512 active site 767468006513 motif I; other site 767468006514 motif II; other site 767468006515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 767468006516 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 767468006517 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 767468006518 maltose O-acetyltransferase; Provisional; Region: PRK10092 767468006519 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 767468006520 active site 767468006521 substrate binding site [chemical binding]; other site 767468006522 trimer interface [polypeptide binding]; other site 767468006523 CoA binding site [chemical binding]; other site 767468006524 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 767468006525 dimer interface [polypeptide binding]; other site 767468006526 ADP-ribose binding site [chemical binding]; other site 767468006527 active site 767468006528 nudix motif; other site 767468006529 metal binding site [ion binding]; metal-binding site 767468006530 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 767468006531 nucleotide binding site/active site [active] 767468006532 HIT family signature motif; other site 767468006533 catalytic residue [active] 767468006534 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 767468006535 classical (c) SDRs; Region: SDR_c; cd05233 767468006536 NAD(P) binding site [chemical binding]; other site 767468006537 active site 767468006538 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 767468006539 Uncharacterized conserved protein [Function unknown]; Region: COG3589 767468006540 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 767468006541 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 767468006542 Sterol carrier protein domain; Region: SCP2_2; pfam13530 767468006543 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 767468006544 HTH domain; Region: HTH_11; pfam08279 767468006545 3H domain; Region: 3H; pfam02829 767468006546 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 767468006547 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 767468006548 active site 767468006549 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468006550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767468006551 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 767468006552 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 767468006553 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767468006554 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 767468006555 Walker A/P-loop; other site 767468006556 ATP binding site [chemical binding]; other site 767468006557 Q-loop/lid; other site 767468006558 ABC transporter signature motif; other site 767468006559 Walker B; other site 767468006560 D-loop; other site 767468006561 H-loop/switch region; other site 767468006562 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 767468006563 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 767468006564 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767468006565 catalytic residue [active] 767468006566 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 767468006567 beta-galactosidase; Region: BGL; TIGR03356 767468006568 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 767468006569 beta-galactosidase; Region: BGL; TIGR03356 767468006570 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 767468006571 active site 767468006572 methionine cluster; other site 767468006573 phosphorylation site [posttranslational modification] 767468006574 metal binding site [ion binding]; metal-binding site 767468006575 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 767468006576 active site 767468006577 P-loop; other site 767468006578 phosphorylation site [posttranslational modification] 767468006579 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 767468006580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767468006581 DNA-binding site [nucleotide binding]; DNA binding site 767468006582 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 767468006583 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 767468006584 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767468006585 active site 767468006586 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767468006587 catalytic core [active] 767468006588 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767468006589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468006590 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767468006591 active site 767468006592 motif I; other site 767468006593 motif II; other site 767468006594 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767468006595 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 767468006596 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 767468006597 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 767468006598 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 767468006599 EamA-like transporter family; Region: EamA; pfam00892 767468006600 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 767468006601 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 767468006602 putative ligand binding site [chemical binding]; other site 767468006603 NAD binding site [chemical binding]; other site 767468006604 catalytic site [active] 767468006605 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 767468006606 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 767468006607 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 767468006608 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 767468006609 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 767468006610 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 767468006611 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 767468006612 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 767468006613 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 767468006614 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 767468006615 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 767468006616 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 767468006617 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 767468006618 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 767468006619 active site 767468006620 catalytic residue [active] 767468006621 dimer interface [polypeptide binding]; other site 767468006622 inner membrane transporter YjeM; Provisional; Region: PRK15238 767468006623 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767468006624 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767468006625 active site 767468006626 catalytic tetrad [active] 767468006627 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767468006628 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767468006629 active site 767468006630 catalytic tetrad [active] 767468006631 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468006632 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767468006633 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 767468006634 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 767468006635 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 767468006636 active site 767468006637 HIGH motif; other site 767468006638 dimer interface [polypeptide binding]; other site 767468006639 KMSKS motif; other site 767468006640 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767468006641 RNA binding surface [nucleotide binding]; other site 767468006642 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 767468006643 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 767468006644 active site 767468006645 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 767468006646 putative active site [active] 767468006647 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 767468006648 Protein of unknown function (DUF554); Region: DUF554; pfam04474 767468006649 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 767468006650 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 767468006651 DNA binding residues [nucleotide binding] 767468006652 drug binding residues [chemical binding]; other site 767468006653 dimer interface [polypeptide binding]; other site 767468006654 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 767468006655 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 767468006656 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 767468006657 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 767468006658 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767468006659 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767468006660 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767468006661 Walker A/P-loop; other site 767468006662 ATP binding site [chemical binding]; other site 767468006663 Q-loop/lid; other site 767468006664 ABC transporter signature motif; other site 767468006665 Walker B; other site 767468006666 D-loop; other site 767468006667 H-loop/switch region; other site 767468006668 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 767468006669 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 767468006670 active site 767468006671 RibD C-terminal domain; Region: RibD_C; cl17279 767468006672 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 767468006673 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 767468006674 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 767468006675 Predicted permeases [General function prediction only]; Region: COG0679 767468006676 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 767468006677 Aspartase; Region: Aspartase; cd01357 767468006678 active sites [active] 767468006679 tetramer interface [polypeptide binding]; other site 767468006680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468006681 putative substrate translocation pore; other site 767468006682 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 767468006683 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 767468006684 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 767468006685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468006686 putative substrate translocation pore; other site 767468006687 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468006688 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 767468006689 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 767468006690 Predicted membrane protein [Function unknown]; Region: COG2855 767468006691 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468006692 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767468006693 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 767468006694 dimerization interface [polypeptide binding]; other site 767468006695 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 767468006696 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 767468006697 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767468006698 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 767468006699 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 767468006700 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767468006701 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767468006702 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 767468006703 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767468006704 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 767468006705 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 767468006706 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 767468006707 DNA binding site [nucleotide binding] 767468006708 active site 767468006709 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 767468006710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468006711 Walker A/P-loop; other site 767468006712 ATP binding site [chemical binding]; other site 767468006713 Q-loop/lid; other site 767468006714 ABC transporter signature motif; other site 767468006715 Walker B; other site 767468006716 D-loop; other site 767468006717 H-loop/switch region; other site 767468006718 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 767468006719 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 767468006720 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 767468006721 classical (c) SDRs; Region: SDR_c; cd05233 767468006722 NAD(P) binding site [chemical binding]; other site 767468006723 active site 767468006724 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 767468006725 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 767468006726 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 767468006727 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 767468006728 DNA binding residues [nucleotide binding] 767468006729 putative dimer interface [polypeptide binding]; other site 767468006730 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 767468006731 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 767468006732 metal binding site [ion binding]; metal-binding site 767468006733 dimer interface [polypeptide binding]; other site 767468006734 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767468006735 FtsX-like permease family; Region: FtsX; pfam02687 767468006736 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767468006737 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 767468006738 FtsX-like permease family; Region: FtsX; pfam02687 767468006739 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767468006740 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767468006741 Walker A/P-loop; other site 767468006742 ATP binding site [chemical binding]; other site 767468006743 Q-loop/lid; other site 767468006744 ABC transporter signature motif; other site 767468006745 Walker B; other site 767468006746 D-loop; other site 767468006747 H-loop/switch region; other site 767468006748 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 767468006749 endonuclease III; Region: ENDO3c; smart00478 767468006750 minor groove reading motif; other site 767468006751 helix-hairpin-helix signature motif; other site 767468006752 substrate binding pocket [chemical binding]; other site 767468006753 active site 767468006754 maltose O-acetyltransferase; Provisional; Region: PRK10092 767468006755 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 767468006756 active site 767468006757 substrate binding site [chemical binding]; other site 767468006758 trimer interface [polypeptide binding]; other site 767468006759 CoA binding site [chemical binding]; other site 767468006760 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 767468006761 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 767468006762 Catalytic site [active] 767468006763 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 767468006764 PYR/PP interface [polypeptide binding]; other site 767468006765 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 767468006766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468006767 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 767468006768 Coenzyme A binding pocket [chemical binding]; other site 767468006769 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767468006770 catalytic core [active] 767468006771 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468006772 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767468006773 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767468006774 dimerization interface [polypeptide binding]; other site 767468006775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767468006776 NAD(P) binding site [chemical binding]; other site 767468006777 NADH(P)-binding; Region: NAD_binding_10; pfam13460 767468006778 active site 767468006779 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 767468006780 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 767468006781 catalytic Zn binding site [ion binding]; other site 767468006782 NAD(P) binding site [chemical binding]; other site 767468006783 structural Zn binding site [ion binding]; other site 767468006784 short chain dehydrogenase; Provisional; Region: PRK06940 767468006785 classical (c) SDRs; Region: SDR_c; cd05233 767468006786 NAD(P) binding site [chemical binding]; other site 767468006787 active site 767468006788 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767468006789 Ligand Binding Site [chemical binding]; other site 767468006790 maltose O-acetyltransferase; Provisional; Region: PRK10092 767468006791 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 767468006792 active site 767468006793 substrate binding site [chemical binding]; other site 767468006794 trimer interface [polypeptide binding]; other site 767468006795 CoA binding site [chemical binding]; other site 767468006796 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 767468006797 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468006798 motif II; other site 767468006799 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468006800 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468006801 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767468006802 MULE transposase domain; Region: MULE; pfam10551 767468006803 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 767468006804 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 767468006805 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 767468006806 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767468006807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468006808 homodimer interface [polypeptide binding]; other site 767468006809 catalytic residue [active] 767468006810 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 767468006811 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767468006812 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767468006813 active site 767468006814 catalytic tetrad [active] 767468006815 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767468006816 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767468006817 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 767468006818 Walker A/P-loop; other site 767468006819 ATP binding site [chemical binding]; other site 767468006820 Q-loop/lid; other site 767468006821 ABC transporter signature motif; other site 767468006822 Walker B; other site 767468006823 D-loop; other site 767468006824 H-loop/switch region; other site 767468006825 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767468006826 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 767468006827 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468006828 Walker A/P-loop; other site 767468006829 ATP binding site [chemical binding]; other site 767468006830 Q-loop/lid; other site 767468006831 ABC transporter signature motif; other site 767468006832 Walker B; other site 767468006833 D-loop; other site 767468006834 H-loop/switch region; other site 767468006835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468006836 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468006837 putative substrate translocation pore; other site 767468006838 Predicted membrane protein [Function unknown]; Region: COG1511 767468006839 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 767468006840 Predicted membrane protein [Function unknown]; Region: COG1511 767468006841 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 767468006842 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468006843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767468006844 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767468006845 dimerization interface [polypeptide binding]; other site 767468006846 putative DNA binding site [nucleotide binding]; other site 767468006847 putative Zn2+ binding site [ion binding]; other site 767468006848 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 767468006849 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 767468006850 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 767468006851 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 767468006852 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 767468006853 CAAX protease self-immunity; Region: Abi; pfam02517 767468006854 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 767468006855 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767468006856 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767468006857 ABC transporter; Region: ABC_tran_2; pfam12848 767468006858 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767468006859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468006860 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767468006861 active site 767468006862 motif I; other site 767468006863 motif II; other site 767468006864 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468006865 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 767468006866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468006867 Walker A/P-loop; other site 767468006868 ATP binding site [chemical binding]; other site 767468006869 Q-loop/lid; other site 767468006870 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 767468006871 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 767468006872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468006873 ABC transporter signature motif; other site 767468006874 Walker B; other site 767468006875 D-loop; other site 767468006876 H-loop/switch region; other site 767468006877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468006878 Walker A/P-loop; other site 767468006879 ATP binding site [chemical binding]; other site 767468006880 Q-loop/lid; other site 767468006881 ABC transporter signature motif; other site 767468006882 Walker B; other site 767468006883 D-loop; other site 767468006884 H-loop/switch region; other site 767468006885 Helix-turn-helix domain; Region: HTH_19; pfam12844 767468006886 sequence-specific DNA binding site [nucleotide binding]; other site 767468006887 salt bridge; other site 767468006888 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 767468006889 Uncharacterized conserved protein [Function unknown]; Region: COG3379 767468006890 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 767468006891 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 767468006892 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 767468006893 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767468006894 DNA-binding site [nucleotide binding]; DNA binding site 767468006895 UTRA domain; Region: UTRA; pfam07702 767468006896 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 767468006897 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 767468006898 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 767468006899 HPr interaction site; other site 767468006900 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767468006901 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 767468006902 active site 767468006903 phosphorylation site [posttranslational modification] 767468006904 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 767468006905 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 767468006906 metal binding site [ion binding]; metal-binding site 767468006907 active site 767468006908 I-site; other site 767468006909 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468006910 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468006911 Integrase core domain; Region: rve; pfam00665 767468006912 EAL domain; Region: EAL; pfam00563 767468006913 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 767468006914 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767468006915 FeS/SAM binding site; other site 767468006916 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 767468006917 Class III ribonucleotide reductase; Region: RNR_III; cd01675 767468006918 effector binding site; other site 767468006919 active site 767468006920 Zn binding site [ion binding]; other site 767468006921 glycine loop; other site 767468006922 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 767468006923 active site 767468006924 catalytic residues [active] 767468006925 metal binding site [ion binding]; metal-binding site 767468006926 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 767468006927 ApbE family; Region: ApbE; pfam02424 767468006928 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 767468006929 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 767468006930 FMN binding site [chemical binding]; other site 767468006931 active site 767468006932 catalytic residues [active] 767468006933 substrate binding site [chemical binding]; other site 767468006934 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 767468006935 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468006936 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767468006937 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767468006938 dimerization interface [polypeptide binding]; other site 767468006939 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 767468006940 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 767468006941 transmembrane helices; other site 767468006942 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 767468006943 Predicted membrane protein [Function unknown]; Region: COG4640 767468006944 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 767468006945 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 767468006946 Double zinc ribbon; Region: DZR; pfam12773 767468006947 Enterocin A Immunity; Region: EntA_Immun; pfam08951 767468006948 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 767468006949 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 767468006950 Collagen binding domain; Region: Collagen_bind; pfam05737 767468006951 EamA-like transporter family; Region: EamA; pfam00892 767468006952 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 767468006953 EamA-like transporter family; Region: EamA; pfam00892 767468006954 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 767468006955 catalytic triad [active] 767468006956 catalytic triad [active] 767468006957 oxyanion hole [active] 767468006958 Amidohydrolase; Region: Amidohydro_2; pfam04909 767468006959 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468006960 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 767468006961 Predicted transcriptional regulators [Transcription]; Region: COG1733 767468006962 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 767468006963 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 767468006964 nucleotide binding site [chemical binding]; other site 767468006965 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 767468006966 active site 767468006967 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767468006968 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767468006969 putative Zn2+ binding site [ion binding]; other site 767468006970 putative DNA binding site [nucleotide binding]; other site 767468006971 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767468006972 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767468006973 DNA binding site [nucleotide binding] 767468006974 domain linker motif; other site 767468006975 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 767468006976 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767468006977 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468006978 active site 767468006979 motif I; other site 767468006980 motif II; other site 767468006981 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767468006982 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 767468006983 dimer interface [polypeptide binding]; other site 767468006984 FMN binding site [chemical binding]; other site 767468006985 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 767468006986 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767468006987 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767468006988 active site turn [active] 767468006989 phosphorylation site [posttranslational modification] 767468006990 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 767468006991 HPr interaction site; other site 767468006992 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767468006993 active site 767468006994 phosphorylation site [posttranslational modification] 767468006995 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 767468006996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468006997 Walker A/P-loop; other site 767468006998 ATP binding site [chemical binding]; other site 767468006999 Q-loop/lid; other site 767468007000 ABC transporter signature motif; other site 767468007001 Walker B; other site 767468007002 D-loop; other site 767468007003 H-loop/switch region; other site 767468007004 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 767468007005 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 767468007006 TM-ABC transporter signature motif; other site 767468007007 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 767468007008 zinc binding site [ion binding]; other site 767468007009 putative ligand binding site [chemical binding]; other site 767468007010 WxL domain surface cell wall-binding; Region: WxL; pfam13731 767468007011 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 767468007012 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 767468007013 WxL domain surface cell wall-binding; Region: WxL; pfam13731 767468007014 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 767468007015 Walker A/P-loop; other site 767468007016 ATP binding site [chemical binding]; other site 767468007017 ABC transporter; Region: ABC_tran; pfam00005 767468007018 Q-loop/lid; other site 767468007019 ABC transporter signature motif; other site 767468007020 Walker B; other site 767468007021 D-loop; other site 767468007022 H-loop/switch region; other site 767468007023 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 767468007024 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 767468007025 Walker A/P-loop; other site 767468007026 ATP binding site [chemical binding]; other site 767468007027 Q-loop/lid; other site 767468007028 ABC transporter signature motif; other site 767468007029 Walker B; other site 767468007030 D-loop; other site 767468007031 H-loop/switch region; other site 767468007032 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 767468007033 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 767468007034 TM-ABC transporter signature motif; other site 767468007035 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 767468007036 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 767468007037 TM-ABC transporter signature motif; other site 767468007038 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 767468007039 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 767468007040 putative ligand binding site [chemical binding]; other site 767468007041 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468007042 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468007043 Integrase core domain; Region: rve; pfam00665 767468007044 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 767468007045 active site 767468007046 Predicted membrane protein [Function unknown]; Region: COG2246 767468007047 GtrA-like protein; Region: GtrA; pfam04138 767468007048 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767468007049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468007050 non-specific DNA binding site [nucleotide binding]; other site 767468007051 salt bridge; other site 767468007052 sequence-specific DNA binding site [nucleotide binding]; other site 767468007053 manganese transport protein MntH; Reviewed; Region: PRK00701 767468007054 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 767468007055 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767468007056 Ligand Binding Site [chemical binding]; other site 767468007057 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 767468007058 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767468007059 dimerization interface [polypeptide binding]; other site 767468007060 putative DNA binding site [nucleotide binding]; other site 767468007061 putative Zn2+ binding site [ion binding]; other site 767468007062 Cadmium resistance transporter; Region: Cad; pfam03596 767468007063 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767468007064 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767468007065 Walker A/P-loop; other site 767468007066 ATP binding site [chemical binding]; other site 767468007067 Q-loop/lid; other site 767468007068 ABC transporter signature motif; other site 767468007069 Walker B; other site 767468007070 D-loop; other site 767468007071 H-loop/switch region; other site 767468007072 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767468007073 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 767468007074 FtsX-like permease family; Region: FtsX; pfam02687 767468007075 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 767468007076 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 767468007077 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 767468007078 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767468007079 active site 767468007080 metal binding site [ion binding]; metal-binding site 767468007081 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767468007082 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468007083 non-specific DNA binding site [nucleotide binding]; other site 767468007084 salt bridge; other site 767468007085 sequence-specific DNA binding site [nucleotide binding]; other site 767468007086 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 767468007087 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767468007088 HPr interaction site; other site 767468007089 active site 767468007090 phosphorylation site [posttranslational modification] 767468007091 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 767468007092 active site 767468007093 P-loop; other site 767468007094 phosphorylation site [posttranslational modification] 767468007095 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 767468007096 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 767468007097 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 767468007098 beta-galactosidase; Region: BGL; TIGR03356 767468007099 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 767468007100 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 767468007101 NADP binding site [chemical binding]; other site 767468007102 putative substrate binding site [chemical binding]; other site 767468007103 active site 767468007104 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 767468007105 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 767468007106 DNA binding residues [nucleotide binding] 767468007107 putative dimer interface [polypeptide binding]; other site 767468007108 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767468007109 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 767468007110 catalytic residue [active] 767468007111 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767468007112 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 767468007113 SdpI/YhfL protein family; Region: SdpI; pfam13630 767468007114 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 767468007115 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 767468007116 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 767468007117 metal binding site [ion binding]; metal-binding site 767468007118 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 767468007119 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 767468007120 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 767468007121 metal binding site [ion binding]; metal-binding site 767468007122 active site 767468007123 I-site; other site 767468007124 DNA polymerase IV; Reviewed; Region: PRK03103 767468007125 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 767468007126 active site 767468007127 DNA binding site [nucleotide binding] 767468007128 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 767468007129 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767468007130 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767468007131 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 767468007132 Walker A/P-loop; other site 767468007133 ATP binding site [chemical binding]; other site 767468007134 Q-loop/lid; other site 767468007135 ABC transporter signature motif; other site 767468007136 Walker B; other site 767468007137 D-loop; other site 767468007138 H-loop/switch region; other site 767468007139 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767468007140 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767468007141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468007142 Walker A/P-loop; other site 767468007143 ATP binding site [chemical binding]; other site 767468007144 Q-loop/lid; other site 767468007145 ABC transporter signature motif; other site 767468007146 Walker B; other site 767468007147 D-loop; other site 767468007148 H-loop/switch region; other site 767468007149 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 767468007150 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 767468007151 metal binding site [ion binding]; metal-binding site 767468007152 dimer interface [polypeptide binding]; other site 767468007153 oxidoreductase; Provisional; Region: PRK06128 767468007154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767468007155 NAD(P) binding site [chemical binding]; other site 767468007156 active site 767468007157 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 767468007158 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767468007159 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468007160 non-specific DNA binding site [nucleotide binding]; other site 767468007161 salt bridge; other site 767468007162 sequence-specific DNA binding site [nucleotide binding]; other site 767468007163 inner membrane transporter YjeM; Provisional; Region: PRK15238 767468007164 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 767468007165 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 767468007166 dimer interface [polypeptide binding]; other site 767468007167 active site 767468007168 metal binding site [ion binding]; metal-binding site 767468007169 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 767468007170 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 767468007171 catalytic Zn binding site [ion binding]; other site 767468007172 NAD binding site [chemical binding]; other site 767468007173 structural Zn binding site [ion binding]; other site 767468007174 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 767468007175 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767468007176 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767468007177 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 767468007178 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 767468007179 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 767468007180 MucBP domain; Region: MucBP; pfam06458 767468007181 Helix-turn-helix domain; Region: HTH_18; pfam12833 767468007182 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767468007183 TfoX C-terminal domain; Region: TfoX_C; pfam04994 767468007184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 767468007185 ATP binding site [chemical binding]; other site 767468007186 Mg2+ binding site [ion binding]; other site 767468007187 G-X-G motif; other site 767468007188 WxL domain surface cell wall-binding; Region: WxL; pfam13731 767468007189 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 767468007190 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 767468007191 WxL domain surface cell wall-binding; Region: WxL; pfam13731 767468007192 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 767468007193 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468007194 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468007195 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 767468007196 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 767468007197 NAD(P) binding site [chemical binding]; other site 767468007198 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 767468007199 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 767468007200 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 767468007201 WxL domain surface cell wall-binding; Region: WxL; pfam13731 767468007202 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 767468007203 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 767468007204 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 767468007205 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 767468007206 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 767468007207 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 767468007208 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 767468007209 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 767468007210 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 767468007211 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 767468007212 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 767468007213 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 767468007214 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 767468007215 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468007216 motif II; other site 767468007217 Predicted transcriptional regulators [Transcription]; Region: COG1733 767468007218 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 767468007219 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 767468007220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468007221 putative substrate translocation pore; other site 767468007222 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 767468007223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 767468007224 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 767468007225 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 767468007226 active site 767468007227 dimer interface [polypeptide binding]; other site 767468007228 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 767468007229 Ligand Binding Site [chemical binding]; other site 767468007230 Molecular Tunnel; other site 767468007231 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 767468007232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767468007233 active site 767468007234 phosphorylation site [posttranslational modification] 767468007235 intermolecular recognition site; other site 767468007236 dimerization interface [polypeptide binding]; other site 767468007237 LytTr DNA-binding domain; Region: LytTR; pfam04397 767468007238 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 767468007239 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468007240 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767468007241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767468007242 NADH(P)-binding; Region: NAD_binding_10; pfam13460 767468007243 NAD(P) binding site [chemical binding]; other site 767468007244 active site 767468007245 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 767468007246 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 767468007247 NAD(P) binding site [chemical binding]; other site 767468007248 catalytic residues [active] 767468007249 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 767468007250 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 767468007251 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 767468007252 active site 767468007253 Bacterial SH3 domain; Region: SH3_5; pfam08460 767468007254 Bacterial SH3 domain; Region: SH3_5; pfam08460 767468007255 Bacterial SH3 domain; Region: SH3_5; pfam08460 767468007256 Bacterial SH3 domain; Region: SH3_5; pfam08460 767468007257 Bacterial SH3 domain; Region: SH3_5; pfam08460 767468007258 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 767468007259 Predicted transcriptional regulators [Transcription]; Region: COG1733 767468007260 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 767468007261 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 767468007262 classical (c) SDRs; Region: SDR_c; cd05233 767468007263 NAD(P) binding site [chemical binding]; other site 767468007264 active site 767468007265 putative transposase OrfB; Reviewed; Region: PHA02517 767468007266 HTH-like domain; Region: HTH_21; pfam13276 767468007267 Integrase core domain; Region: rve; pfam00665 767468007268 Integrase core domain; Region: rve_2; pfam13333 767468007269 Winged helix-turn helix; Region: HTH_29; pfam13551 767468007270 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468007271 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767468007272 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468007273 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468007274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767468007275 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 767468007276 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 767468007277 NADP binding site [chemical binding]; other site 767468007278 putative substrate binding site [chemical binding]; other site 767468007279 active site 767468007280 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 767468007281 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468007282 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468007283 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 767468007284 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 767468007285 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 767468007286 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 767468007287 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 767468007288 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 767468007289 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 767468007290 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 767468007291 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 767468007292 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 767468007293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468007294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767468007295 GTP-binding protein LepA; Provisional; Region: PRK05433 767468007296 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 767468007297 G1 box; other site 767468007298 putative GEF interaction site [polypeptide binding]; other site 767468007299 GTP/Mg2+ binding site [chemical binding]; other site 767468007300 Switch I region; other site 767468007301 G2 box; other site 767468007302 G3 box; other site 767468007303 Switch II region; other site 767468007304 G4 box; other site 767468007305 G5 box; other site 767468007306 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 767468007307 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 767468007308 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 767468007309 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 767468007310 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 767468007311 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 767468007312 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 767468007313 putative NADH binding site [chemical binding]; other site 767468007314 putative active site [active] 767468007315 nudix motif; other site 767468007316 putative metal binding site [ion binding]; other site 767468007317 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468007318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767468007319 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767468007320 dimerization interface [polypeptide binding]; other site 767468007321 hypothetical protein; Validated; Region: PRK07121 767468007322 Predicted oxidoreductase [General function prediction only]; Region: COG3573 767468007323 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 767468007324 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 767468007325 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 767468007326 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 767468007327 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 767468007328 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 767468007329 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 767468007330 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 767468007331 dimerization interface [polypeptide binding]; other site 767468007332 DPS ferroxidase diiron center [ion binding]; other site 767468007333 ion pore; other site 767468007334 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 767468007335 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767468007336 DNA-binding site [nucleotide binding]; DNA binding site 767468007337 UTRA domain; Region: UTRA; pfam07702 767468007338 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 767468007339 beta-galactosidase; Region: BGL; TIGR03356 767468007340 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 767468007341 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 767468007342 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 767468007343 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 767468007344 Protein of unknown function (DUF805); Region: DUF805; pfam05656 767468007345 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 767468007346 Protein of unknown function (DUF3781); Region: DUF3781; pfam12636 767468007347 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 767468007348 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 767468007349 conserved cys residue [active] 767468007350 Predicted transcriptional regulators [Transcription]; Region: COG1733 767468007351 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 767468007352 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767468007353 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767468007354 Walker A/P-loop; other site 767468007355 ATP binding site [chemical binding]; other site 767468007356 Q-loop/lid; other site 767468007357 ABC transporter signature motif; other site 767468007358 Walker B; other site 767468007359 D-loop; other site 767468007360 H-loop/switch region; other site 767468007361 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468007362 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767468007363 sequence-specific DNA binding site [nucleotide binding]; other site 767468007364 salt bridge; other site 767468007365 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 767468007366 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767468007367 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468007368 non-specific DNA binding site [nucleotide binding]; other site 767468007369 salt bridge; other site 767468007370 sequence-specific DNA binding site [nucleotide binding]; other site 767468007371 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 767468007372 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 767468007373 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 767468007374 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767468007375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767468007376 Walker A/P-loop; other site 767468007377 ATP binding site [chemical binding]; other site 767468007378 Q-loop/lid; other site 767468007379 ABC transporter signature motif; other site 767468007380 Walker B; other site 767468007381 D-loop; other site 767468007382 H-loop/switch region; other site 767468007383 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767468007384 catalytic core [active] 767468007385 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767468007386 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 767468007387 Domain of unknown function DUF20; Region: UPF0118; pfam01594 767468007388 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 767468007389 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 767468007390 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 767468007391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767468007392 S-adenosylmethionine binding site [chemical binding]; other site 767468007393 Catalytic domain of Protein Kinases; Region: PKc; cd00180 767468007394 active site 767468007395 ATP binding site [chemical binding]; other site 767468007396 substrate binding site [chemical binding]; other site 767468007397 activation loop (A-loop); other site 767468007398 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 767468007399 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468007400 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468007401 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 767468007402 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 767468007403 AzlC protein; Region: AzlC; pfam03591 767468007404 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 767468007405 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 767468007406 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 767468007407 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 767468007408 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 767468007409 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 767468007410 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767468007411 dimer interface [polypeptide binding]; other site 767468007412 phosphorylation site [posttranslational modification] 767468007413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767468007414 ATP binding site [chemical binding]; other site 767468007415 Mg2+ binding site [ion binding]; other site 767468007416 G-X-G motif; other site 767468007417 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767468007418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767468007419 active site 767468007420 phosphorylation site [posttranslational modification] 767468007421 intermolecular recognition site; other site 767468007422 dimerization interface [polypeptide binding]; other site 767468007423 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767468007424 DNA binding site [nucleotide binding] 767468007425 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 767468007426 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 767468007427 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 767468007428 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 767468007429 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 767468007430 active site 767468007431 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 767468007432 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 767468007433 GTP-binding protein YchF; Reviewed; Region: PRK09601 767468007434 YchF GTPase; Region: YchF; cd01900 767468007435 G1 box; other site 767468007436 GTP/Mg2+ binding site [chemical binding]; other site 767468007437 Switch I region; other site 767468007438 G2 box; other site 767468007439 Switch II region; other site 767468007440 G3 box; other site 767468007441 G4 box; other site 767468007442 G5 box; other site 767468007443 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 767468007444 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 767468007445 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 767468007446 ParB-like nuclease domain; Region: ParB; smart00470 767468007447 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 767468007448 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 767468007449 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767468007450 P-loop; other site 767468007451 Magnesium ion binding site [ion binding]; other site 767468007452 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767468007453 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 767468007454 ParB-like nuclease domain; Region: ParBc; pfam02195 767468007455 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 767468007456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767468007457 S-adenosylmethionine binding site [chemical binding]; other site 767468007458 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 767468007459 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 767468007460 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 767468007461 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 767468007462 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468007463 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468007464 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 767468007465 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767468007466 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468007467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767468007468 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767468007469 dimerization interface [polypeptide binding]; other site 767468007470 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767468007471 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 767468007472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468007473 homodimer interface [polypeptide binding]; other site 767468007474 catalytic residue [active] 767468007475 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767468007476 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767468007477 substrate binding pocket [chemical binding]; other site 767468007478 membrane-bound complex binding site; other site 767468007479 hinge residues; other site 767468007480 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 767468007481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468007482 dimer interface [polypeptide binding]; other site 767468007483 conserved gate region; other site 767468007484 putative PBP binding loops; other site 767468007485 ABC-ATPase subunit interface; other site 767468007486 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767468007487 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767468007488 Walker A/P-loop; other site 767468007489 ATP binding site [chemical binding]; other site 767468007490 Q-loop/lid; other site 767468007491 ABC transporter signature motif; other site 767468007492 Walker B; other site 767468007493 D-loop; other site 767468007494 H-loop/switch region; other site 767468007495 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767468007496 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767468007497 substrate binding pocket [chemical binding]; other site 767468007498 membrane-bound complex binding site; other site 767468007499 hinge residues; other site 767468007500 Predicted transcriptional regulators [Transcription]; Region: COG1695 767468007501 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 767468007502 Predicted membrane protein [Function unknown]; Region: COG4709 767468007503 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 767468007504 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 767468007505 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 767468007506 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767468007507 active site turn [active] 767468007508 phosphorylation site [posttranslational modification] 767468007509 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767468007510 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 767468007511 HPr interaction site; other site 767468007512 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767468007513 active site 767468007514 phosphorylation site [posttranslational modification] 767468007515 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 767468007516 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 767468007517 Ca binding site [ion binding]; other site 767468007518 active site 767468007519 catalytic site [active] 767468007520 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 767468007521 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 767468007522 putative dimerization interface [polypeptide binding]; other site 767468007523 putative ligand binding site [chemical binding]; other site 767468007524 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 767468007525 putative active site [active] 767468007526 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 767468007527 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 767468007528 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767468007529 Walker A/P-loop; other site 767468007530 ATP binding site [chemical binding]; other site 767468007531 Q-loop/lid; other site 767468007532 ABC transporter signature motif; other site 767468007533 Walker B; other site 767468007534 D-loop; other site 767468007535 H-loop/switch region; other site 767468007536 TRAM domain; Region: TRAM; cl01282 767468007537 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 767468007538 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 767468007539 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 767468007540 NADP binding site [chemical binding]; other site 767468007541 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468007542 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767468007543 active site 767468007544 motif I; other site 767468007545 motif II; other site 767468007546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468007547 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 767468007548 ROK family; Region: ROK; pfam00480 767468007549 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 767468007550 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 767468007551 active site 767468007552 metal binding site [ion binding]; metal-binding site 767468007553 catalytic site [active] 767468007554 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 767468007555 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 767468007556 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 767468007557 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 767468007558 active site 767468007559 P-loop; other site 767468007560 phosphorylation site [posttranslational modification] 767468007561 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 767468007562 active site 767468007563 phosphorylation site [posttranslational modification] 767468007564 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 767468007565 HTH domain; Region: HTH_11; pfam08279 767468007566 PRD domain; Region: PRD; pfam00874 767468007567 PRD domain; Region: PRD; pfam00874 767468007568 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 767468007569 active site 767468007570 P-loop; other site 767468007571 phosphorylation site [posttranslational modification] 767468007572 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 767468007573 active site 767468007574 phosphorylation site [posttranslational modification] 767468007575 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468007576 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468007577 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 767468007578 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 767468007579 DNA binding residues [nucleotide binding] 767468007580 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 767468007581 putative dimer interface [polypeptide binding]; other site 767468007582 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 767468007583 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 767468007584 NADP binding site [chemical binding]; other site 767468007585 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 767468007586 HPr interaction site; other site 767468007587 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767468007588 active site 767468007589 phosphorylation site [posttranslational modification] 767468007590 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 767468007591 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767468007592 active site turn [active] 767468007593 phosphorylation site [posttranslational modification] 767468007594 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767468007595 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 767468007596 endonuclease III; Region: ENDO3c; smart00478 767468007597 minor groove reading motif; other site 767468007598 helix-hairpin-helix signature motif; other site 767468007599 substrate binding pocket [chemical binding]; other site 767468007600 active site 767468007601 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767468007602 Predicted flavoprotein [General function prediction only]; Region: COG0431 767468007603 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 767468007604 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 767468007605 metal binding site 2 [ion binding]; metal-binding site 767468007606 putative DNA binding helix; other site 767468007607 metal binding site 1 [ion binding]; metal-binding site 767468007608 dimer interface [polypeptide binding]; other site 767468007609 structural Zn2+ binding site [ion binding]; other site 767468007610 Enterocin A Immunity; Region: EntA_Immun; pfam08951 767468007611 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 767468007612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468007613 Coenzyme A binding pocket [chemical binding]; other site 767468007614 LrgA family; Region: LrgA; pfam03788 767468007615 LrgB-like family; Region: LrgB; pfam04172 767468007616 EDD domain protein, DegV family; Region: DegV; TIGR00762 767468007617 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767468007618 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 767468007619 phytoene desaturase; Region: crtI_fam; TIGR02734 767468007620 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767468007621 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 767468007622 active site lid residues [active] 767468007623 substrate binding pocket [chemical binding]; other site 767468007624 catalytic residues [active] 767468007625 substrate-Mg2+ binding site; other site 767468007626 aspartate-rich region 1; other site 767468007627 aspartate-rich region 2; other site 767468007628 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 767468007629 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 767468007630 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 767468007631 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 767468007632 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767468007633 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767468007634 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767468007635 Enterocin A Immunity; Region: EntA_Immun; pfam08951 767468007636 adenylosuccinate lyase; Provisional; Region: PRK07492 767468007637 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 767468007638 tetramer interface [polypeptide binding]; other site 767468007639 active site 767468007640 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 767468007641 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 767468007642 GDP-binding site [chemical binding]; other site 767468007643 ACT binding site; other site 767468007644 IMP binding site; other site 767468007645 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 767468007646 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 767468007647 active site 767468007648 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 767468007649 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 767468007650 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 767468007651 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 767468007652 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 767468007653 putative active site [active] 767468007654 catalytic site [active] 767468007655 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 767468007656 putative active site [active] 767468007657 catalytic site [active] 767468007658 amino acid transporter; Region: 2A0306; TIGR00909 767468007659 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 767468007660 K+ potassium transporter; Region: K_trans; pfam02705 767468007661 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 767468007662 Cation efflux family; Region: Cation_efflux; pfam01545 767468007663 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 767468007664 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 767468007665 substrate binding site [chemical binding]; other site 767468007666 THF binding site; other site 767468007667 zinc-binding site [ion binding]; other site 767468007668 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 767468007669 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 767468007670 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 767468007671 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 767468007672 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767468007673 dimerization interface [polypeptide binding]; other site 767468007674 putative DNA binding site [nucleotide binding]; other site 767468007675 putative Zn2+ binding site [ion binding]; other site 767468007676 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 767468007677 flagellar motor protein MotB; Validated; Region: motB; PRK09041 767468007678 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 767468007679 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 767468007680 dihydropteroate synthase; Region: DHPS; TIGR01496 767468007681 substrate binding pocket [chemical binding]; other site 767468007682 dimer interface [polypeptide binding]; other site 767468007683 inhibitor binding site; inhibition site 767468007684 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 767468007685 active site 767468007686 dimerization interface [polypeptide binding]; other site 767468007687 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 767468007688 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767468007689 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 767468007690 active site 767468007691 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 767468007692 catalytic center binding site [active] 767468007693 ATP binding site [chemical binding]; other site 767468007694 Dihydroneopterin aldolase; Region: FolB; pfam02152 767468007695 active site 767468007696 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 767468007697 Colicin V production protein; Region: Colicin_V; pfam02674 767468007698 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 767468007699 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 767468007700 metal binding site [ion binding]; metal-binding site 767468007701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468007702 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468007703 putative substrate translocation pore; other site 767468007704 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767468007705 Beta-lactamase; Region: Beta-lactamase; pfam00144 767468007706 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 767468007707 Pyruvate formate lyase 1; Region: PFL1; cd01678 767468007708 coenzyme A binding site [chemical binding]; other site 767468007709 active site 767468007710 catalytic residues [active] 767468007711 glycine loop; other site 767468007712 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 767468007713 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767468007714 FeS/SAM binding site; other site 767468007715 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 767468007716 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767468007717 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767468007718 active site 767468007719 catalytic tetrad [active] 767468007720 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 767468007721 nucleotide binding site/active site [active] 767468007722 HIT family signature motif; other site 767468007723 catalytic residue [active] 767468007724 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 767468007725 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 767468007726 active site 767468007727 catalytic triad [active] 767468007728 oxyanion hole [active] 767468007729 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468007730 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468007731 Integrase core domain; Region: rve; pfam00665 767468007732 BCCT family transporter; Region: BCCT; pfam02028 767468007733 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 767468007734 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767468007735 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767468007736 Protein of unknown function (DUF419); Region: DUF419; cl15265 767468007737 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 767468007738 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767468007739 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 767468007740 active site 767468007741 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 767468007742 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 767468007743 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 767468007744 dimer interface [polypeptide binding]; other site 767468007745 active site 767468007746 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 767468007747 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 767468007748 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 767468007749 Spore germination protein; Region: Spore_permease; cl17796 767468007750 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 767468007751 tetramer interfaces [polypeptide binding]; other site 767468007752 binuclear metal-binding site [ion binding]; other site 767468007753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767468007754 NmrA-like family; Region: NmrA; pfam05368 767468007755 NAD(P) binding site [chemical binding]; other site 767468007756 active site 767468007757 Transcriptional regulators [Transcription]; Region: MarR; COG1846 767468007758 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 767468007759 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 767468007760 ArsC family; Region: ArsC; pfam03960 767468007761 putative catalytic residues [active] 767468007762 thiol/disulfide switch; other site 767468007763 Uncharacterized conserved protein [Function unknown]; Region: COG3189 767468007764 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 767468007765 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 767468007766 minor groove reading motif; other site 767468007767 helix-hairpin-helix signature motif; other site 767468007768 substrate binding pocket [chemical binding]; other site 767468007769 active site 767468007770 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 767468007771 DNA binding and oxoG recognition site [nucleotide binding] 767468007772 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 767468007773 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 767468007774 putative dimer interface [polypeptide binding]; other site 767468007775 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 767468007776 NADH(P)-binding; Region: NAD_binding_10; pfam13460 767468007777 putative NAD(P) binding site [chemical binding]; other site 767468007778 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 767468007779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468007780 Coenzyme A binding pocket [chemical binding]; other site 767468007781 EamA-like transporter family; Region: EamA; pfam00892 767468007782 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 767468007783 EamA-like transporter family; Region: EamA; pfam00892 767468007784 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 767468007785 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 767468007786 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 767468007787 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 767468007788 active site 767468007789 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 767468007790 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767468007791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468007792 motif II; other site 767468007793 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 767468007794 Penicillinase repressor; Region: Pencillinase_R; pfam03965 767468007795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468007796 putative substrate translocation pore; other site 767468007797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468007798 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 767468007799 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 767468007800 Na binding site [ion binding]; other site 767468007801 drug efflux system protein MdtG; Provisional; Region: PRK09874 767468007802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468007803 putative substrate translocation pore; other site 767468007804 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 767468007805 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767468007806 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 767468007807 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 767468007808 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 767468007809 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 767468007810 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767468007811 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 767468007812 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468007813 active site 767468007814 motif I; other site 767468007815 motif II; other site 767468007816 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 767468007817 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 767468007818 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 767468007819 active site 767468007820 metal binding site [ion binding]; metal-binding site 767468007821 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 767468007822 Membrane transport protein; Region: Mem_trans; cl09117 767468007823 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767468007824 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767468007825 active site 767468007826 catalytic tetrad [active] 767468007827 Uncharacterized conserved protein [Function unknown]; Region: COG2966 767468007828 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 767468007829 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 767468007830 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 767468007831 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 767468007832 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 767468007833 putative ADP-ribose binding site [chemical binding]; other site 767468007834 putative active site [active] 767468007835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767468007836 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468007837 Predicted secreted protein [Function unknown]; Region: COG4086 767468007838 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 767468007839 WxL domain surface cell wall-binding; Region: WxL; pfam13731 767468007840 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 767468007841 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 767468007842 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468007843 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468007844 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 767468007845 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 767468007846 WxL domain surface cell wall-binding; Region: WxL; pfam13731 767468007847 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 767468007848 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767468007849 MarR family; Region: MarR_2; pfam12802 767468007850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468007851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767468007852 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 767468007853 active site 767468007854 nucleotide-binding site [chemical binding]; other site 767468007855 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 767468007856 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 767468007857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468007858 catalytic residue [active] 767468007859 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767468007860 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767468007861 NlpC/P60 family; Region: NLPC_P60; pfam00877 767468007862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468007863 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 767468007864 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 767468007865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767468007866 S-adenosylmethionine binding site [chemical binding]; other site 767468007867 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 767468007868 putative active site [active] 767468007869 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 767468007870 active site 767468007871 catalytic triad [active] 767468007872 oxyanion hole [active] 767468007873 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 767468007874 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767468007875 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767468007876 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 767468007877 amphipathic channel; other site 767468007878 Asn-Pro-Ala signature motifs; other site 767468007879 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 767468007880 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 767468007881 catalytic residues [active] 767468007882 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 767468007883 putative homodimer interface [polypeptide binding]; other site 767468007884 putative homotetramer interface [polypeptide binding]; other site 767468007885 putative metal binding site [ion binding]; other site 767468007886 putative homodimer-homodimer interface [polypeptide binding]; other site 767468007887 putative allosteric switch controlling residues; other site 767468007888 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 767468007889 Ferritin-like domain; Region: Ferritin; pfam00210 767468007890 dimerization interface [polypeptide binding]; other site 767468007891 DPS ferroxidase diiron center [ion binding]; other site 767468007892 ion pore; other site 767468007893 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 767468007894 metal-binding site [ion binding] 767468007895 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 767468007896 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 767468007897 ligand binding site [chemical binding]; other site 767468007898 flexible hinge region; other site 767468007899 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 767468007900 non-specific DNA interactions [nucleotide binding]; other site 767468007901 DNA binding site [nucleotide binding] 767468007902 sequence specific DNA binding site [nucleotide binding]; other site 767468007903 putative cAMP binding site [chemical binding]; other site 767468007904 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 767468007905 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 767468007906 active site 767468007907 Zn binding site [ion binding]; other site 767468007908 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 767468007909 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767468007910 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767468007911 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767468007912 legume lectins; Region: lectin_L-type; cl14058 767468007913 homotetramer interaction site [polypeptide binding]; other site 767468007914 carbohydrate binding site [chemical binding]; other site 767468007915 metal binding site [ion binding]; metal-binding site 767468007916 WxL domain surface cell wall-binding; Region: WxL; pfam13731 767468007917 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 767468007918 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 767468007919 WxL domain surface cell wall-binding; Region: WxL; pfam13731 767468007920 WxL domain surface cell wall-binding; Region: WxL; pfam13731 767468007921 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767468007922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767468007923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 767468007924 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 767468007925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468007926 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767468007927 Walker A motif; other site 767468007928 ATP binding site [chemical binding]; other site 767468007929 Walker B motif; other site 767468007930 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 767468007931 amphipathic channel; other site 767468007932 Asn-Pro-Ala signature motifs; other site 767468007933 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 767468007934 ABC1 family; Region: ABC1; cl17513 767468007935 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 767468007936 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 767468007937 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468007938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468007939 putative substrate translocation pore; other site 767468007940 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 767468007941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468007942 putative substrate translocation pore; other site 767468007943 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468007944 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 767468007945 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 767468007946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767468007947 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468007948 non-specific DNA binding site [nucleotide binding]; other site 767468007949 salt bridge; other site 767468007950 sequence-specific DNA binding site [nucleotide binding]; other site 767468007951 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 767468007952 FIC domain binding interface [polypeptide binding]; other site 767468007953 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 767468007954 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767468007955 DNA binding site [nucleotide binding] 767468007956 domain linker motif; other site 767468007957 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 767468007958 putative dimerization interface [polypeptide binding]; other site 767468007959 putative ligand binding site [chemical binding]; other site 767468007960 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 767468007961 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 767468007962 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 767468007963 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 767468007964 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 767468007965 NAD binding site [chemical binding]; other site 767468007966 homodimer interface [polypeptide binding]; other site 767468007967 active site 767468007968 substrate binding site [chemical binding]; other site 767468007969 galactokinase; Provisional; Region: PRK05322 767468007970 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 767468007971 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767468007972 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 767468007973 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 767468007974 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 767468007975 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 767468007976 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 767468007977 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 767468007978 Melibiase; Region: Melibiase; pfam02065 767468007979 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 767468007980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468007981 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 767468007982 HPr interaction site; other site 767468007983 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767468007984 active site 767468007985 phosphorylation site [posttranslational modification] 767468007986 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 767468007987 active site 767468007988 catalytic residues [active] 767468007989 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767468007990 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767468007991 DNA binding site [nucleotide binding] 767468007992 domain linker motif; other site 767468007993 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 767468007994 putative dimerization interface [polypeptide binding]; other site 767468007995 putative ligand binding site [chemical binding]; other site 767468007996 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767468007997 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767468007998 active site 767468007999 catalytic tetrad [active] 767468008000 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 767468008001 FMN-binding domain; Region: FMN_bind; cl01081 767468008002 L-aspartate oxidase; Provisional; Region: PRK06175 767468008003 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 767468008004 Predicted flavoprotein [General function prediction only]; Region: COG0431 767468008005 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767468008006 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 767468008007 ApbE family; Region: ApbE; pfam02424 767468008008 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 767468008009 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 767468008010 active site 767468008011 catalytic residue [active] 767468008012 dimer interface [polypeptide binding]; other site 767468008013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468008014 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468008015 putative substrate translocation pore; other site 767468008016 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 767468008017 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 767468008018 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 767468008019 shikimate binding site; other site 767468008020 NAD(P) binding site [chemical binding]; other site 767468008021 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468008022 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767468008023 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 767468008024 putative dimerization interface [polypeptide binding]; other site 767468008025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468008026 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468008027 putative substrate translocation pore; other site 767468008028 Putative esterase; Region: Esterase; pfam00756 767468008029 S-formylglutathione hydrolase; Region: PLN02442 767468008030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 767468008031 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 767468008032 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767468008033 DNA-binding site [nucleotide binding]; DNA binding site 767468008034 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 767468008035 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 767468008036 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 767468008037 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570 767468008038 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 767468008039 putative active site [active] 767468008040 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 767468008041 Uncharacterized conserved protein [Function unknown]; Region: COG3589 767468008042 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 767468008043 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 767468008044 beta-galactosidase; Region: BGL; TIGR03356 767468008045 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 767468008046 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767468008047 active site turn [active] 767468008048 phosphorylation site [posttranslational modification] 767468008049 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767468008050 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 767468008051 HPr interaction site; other site 767468008052 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767468008053 active site 767468008054 phosphorylation site [posttranslational modification] 767468008055 transcriptional antiterminator BglG; Provisional; Region: PRK09772 767468008056 CAT RNA binding domain; Region: CAT_RBD; smart01061 767468008057 PRD domain; Region: PRD; pfam00874 767468008058 PRD domain; Region: PRD; pfam00874 767468008059 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 767468008060 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 767468008061 beta-galactosidase; Region: BGL; TIGR03356 767468008062 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 767468008063 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767468008064 active site turn [active] 767468008065 phosphorylation site [posttranslational modification] 767468008066 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767468008067 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 767468008068 HPr interaction site; other site 767468008069 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767468008070 active site 767468008071 phosphorylation site [posttranslational modification] 767468008072 transcriptional antiterminator BglG; Provisional; Region: PRK09772 767468008073 CAT RNA binding domain; Region: CAT_RBD; smart01061 767468008074 PRD domain; Region: PRD; pfam00874 767468008075 PRD domain; Region: PRD; pfam00874 767468008076 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 767468008077 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 767468008078 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 767468008079 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 767468008080 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767468008081 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767468008082 DNA binding site [nucleotide binding] 767468008083 domain linker motif; other site 767468008084 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 767468008085 dimerization interface [polypeptide binding]; other site 767468008086 ligand binding site [chemical binding]; other site 767468008087 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767468008088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468008089 putative substrate translocation pore; other site 767468008090 putative alpha-glucosidase; Provisional; Region: PRK10658 767468008091 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 767468008092 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 767468008093 trimer interface [polypeptide binding]; other site 767468008094 active site 767468008095 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 767468008096 catalytic site [active] 767468008097 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468008098 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468008099 Integrase core domain; Region: rve; pfam00665 767468008100 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 767468008101 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 767468008102 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767468008103 MULE transposase domain; Region: MULE; pfam10551 767468008104 sugar phosphate phosphatase; Provisional; Region: PRK10513 767468008105 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468008106 active site 767468008107 motif I; other site 767468008108 motif II; other site 767468008109 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767468008110 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 767468008111 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 767468008112 TPP-binding site [chemical binding]; other site 767468008113 dimer interface [polypeptide binding]; other site 767468008114 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 767468008115 PYR/PP interface [polypeptide binding]; other site 767468008116 dimer interface [polypeptide binding]; other site 767468008117 TPP binding site [chemical binding]; other site 767468008118 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767468008119 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 767468008120 active site 767468008121 intersubunit interactions; other site 767468008122 catalytic residue [active] 767468008123 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 767468008124 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 767468008125 active site 767468008126 P-loop; other site 767468008127 phosphorylation site [posttranslational modification] 767468008128 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 767468008129 active site 767468008130 phosphorylation site [posttranslational modification] 767468008131 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 767468008132 PRD domain; Region: PRD; pfam00874 767468008133 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 767468008134 active site 767468008135 P-loop; other site 767468008136 phosphorylation site [posttranslational modification] 767468008137 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 767468008138 active site 767468008139 phosphorylation site [posttranslational modification] 767468008140 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 767468008141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468008142 motif II; other site 767468008143 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 767468008144 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 767468008145 putative NAD(P) binding site [chemical binding]; other site 767468008146 catalytic Zn binding site [ion binding]; other site 767468008147 structural Zn binding site [ion binding]; other site 767468008148 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 767468008149 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 767468008150 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 767468008151 active site 767468008152 P-loop; other site 767468008153 phosphorylation site [posttranslational modification] 767468008154 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 767468008155 active site 767468008156 phosphorylation site [posttranslational modification] 767468008157 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 767468008158 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 767468008159 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 767468008160 putative phosphoketolase; Provisional; Region: PRK05261 767468008161 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 767468008162 TPP-binding site; other site 767468008163 XFP C-terminal domain; Region: XFP_C; pfam09363 767468008164 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 767468008165 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 767468008166 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 767468008167 putative active site [active] 767468008168 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 767468008169 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 767468008170 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767468008171 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 767468008172 Na binding site [ion binding]; other site 767468008173 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 767468008174 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 767468008175 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 767468008176 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 767468008177 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 767468008178 nucleotide binding site [chemical binding]; other site 767468008179 N-acetylneuraminate lyase; Provisional; Region: PRK04147 767468008180 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 767468008181 inhibitor site; inhibition site 767468008182 active site 767468008183 dimer interface [polypeptide binding]; other site 767468008184 catalytic residue [active] 767468008185 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 767468008186 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 767468008187 putative active site cavity [active] 767468008188 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 767468008189 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767468008190 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767468008191 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468008192 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468008193 Integrase core domain; Region: rve; pfam00665 767468008194 conserved hypothetical protein; Region: TIGR02328 767468008195 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 767468008196 putative transposase OrfB; Reviewed; Region: PHA02517 767468008197 HTH-like domain; Region: HTH_21; pfam13276 767468008198 Integrase core domain; Region: rve; pfam00665 767468008199 Integrase core domain; Region: rve_2; pfam13333 767468008200 Winged helix-turn helix; Region: HTH_29; pfam13551 767468008201 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468008202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767468008203 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468008204 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 767468008205 Predicted membrane protein [Function unknown]; Region: COG2261 767468008206 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 767468008207 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 767468008208 heme binding pocket [chemical binding]; other site 767468008209 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 767468008210 ArsC family; Region: ArsC; pfam03960 767468008211 putative catalytic residues [active] 767468008212 thiol/disulfide switch; other site 767468008213 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 767468008214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767468008215 active site 767468008216 phosphorylation site [posttranslational modification] 767468008217 intermolecular recognition site; other site 767468008218 dimerization interface [polypeptide binding]; other site 767468008219 LytTr DNA-binding domain; Region: LytTR; pfam04397 767468008220 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 767468008221 Accessory gene regulator B; Region: AgrB; smart00793 767468008222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468008223 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767468008224 Walker A motif; other site 767468008225 ATP binding site [chemical binding]; other site 767468008226 Walker B motif; other site 767468008227 arginine finger; other site 767468008228 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767468008229 Walker A motif; other site 767468008230 ATP binding site [chemical binding]; other site 767468008231 Walker B motif; other site 767468008232 arginine finger; other site 767468008233 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 767468008234 pyruvate oxidase; Provisional; Region: PRK08611 767468008235 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 767468008236 PYR/PP interface [polypeptide binding]; other site 767468008237 dimer interface [polypeptide binding]; other site 767468008238 tetramer interface [polypeptide binding]; other site 767468008239 TPP binding site [chemical binding]; other site 767468008240 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 767468008241 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 767468008242 TPP-binding site [chemical binding]; other site 767468008243 Predicted transcriptional regulator [Transcription]; Region: COG1959 767468008244 Transcriptional regulator; Region: Rrf2; pfam02082 767468008245 Transcriptional regulator; Region: Rrf2; cl17282 767468008246 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 767468008247 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 767468008248 PYR/PP interface [polypeptide binding]; other site 767468008249 dimer interface [polypeptide binding]; other site 767468008250 tetramer interface [polypeptide binding]; other site 767468008251 TPP binding site [chemical binding]; other site 767468008252 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 767468008253 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 767468008254 TPP-binding site [chemical binding]; other site 767468008255 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 767468008256 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 767468008257 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 767468008258 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 767468008259 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 767468008260 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 767468008261 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 767468008262 HTH domain; Region: HTH_11; pfam08279 767468008263 PRD domain; Region: PRD; pfam00874 767468008264 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 767468008265 active site 767468008266 phosphorylation site [posttranslational modification] 767468008267 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 767468008268 classical (c) SDRs; Region: SDR_c; cd05233 767468008269 NAD(P) binding site [chemical binding]; other site 767468008270 active site 767468008271 Sugar transport protein; Region: Sugar_transport; pfam06800 767468008272 D-ribose pyranase; Provisional; Region: PRK11797 767468008273 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 767468008274 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 767468008275 substrate binding site [chemical binding]; other site 767468008276 dimer interface [polypeptide binding]; other site 767468008277 ATP binding site [chemical binding]; other site 767468008278 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767468008279 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767468008280 DNA binding site [nucleotide binding] 767468008281 domain linker motif; other site 767468008282 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 767468008283 dimerization interface [polypeptide binding]; other site 767468008284 ligand binding site [chemical binding]; other site 767468008285 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468008286 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468008287 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 767468008288 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 767468008289 putative catalytic cysteine [active] 767468008290 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 767468008291 putative active site [active] 767468008292 metal binding site [ion binding]; metal-binding site 767468008293 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767468008294 Ligand Binding Site [chemical binding]; other site 767468008295 Predicted transcriptional regulators [Transcription]; Region: COG1695 767468008296 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 767468008297 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 767468008298 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 767468008299 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468008300 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468008301 Integrase core domain; Region: rve; pfam00665 767468008302 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 767468008303 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 767468008304 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 767468008305 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767468008306 Coenzyme A binding pocket [chemical binding]; other site 767468008307 EDD domain protein, DegV family; Region: DegV; TIGR00762 767468008308 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767468008309 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468008310 non-specific DNA binding site [nucleotide binding]; other site 767468008311 salt bridge; other site 767468008312 sequence-specific DNA binding site [nucleotide binding]; other site 767468008313 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 767468008314 trimer interface [polypeptide binding]; other site 767468008315 active site 767468008316 G bulge; other site 767468008317 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 767468008318 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 767468008319 Catalytic site [active] 767468008320 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 767468008321 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 767468008322 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 767468008323 WxL domain surface cell wall-binding; Region: WxL; pfam13731 767468008324 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 767468008325 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 767468008326 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 767468008327 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 767468008328 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 767468008329 trmE is a tRNA modification GTPase; Region: trmE; cd04164 767468008330 G1 box; other site 767468008331 GTP/Mg2+ binding site [chemical binding]; other site 767468008332 Switch I region; other site 767468008333 G2 box; other site 767468008334 Switch II region; other site 767468008335 G3 box; other site 767468008336 G4 box; other site 767468008337 G5 box; other site 767468008338 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 767468008339 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 767468008340 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 767468008341 G-X-X-G motif; other site 767468008342 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 767468008343 RxxxH motif; other site 767468008344 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 767468008345 Amidohydrolase; Region: Amidohydro_4; pfam13147 767468008346 active site 767468008347 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767468008348 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767468008349 peptide binding site [polypeptide binding]; other site 767468008350 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 767468008351 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 767468008352 ribonuclease P; Reviewed; Region: rnpA; PRK00499 767468008353 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 767468008354 domain interaction interfaces [polypeptide binding]; other site 767468008355 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 767468008356 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 767468008357 Melibiase; Region: Melibiase; pfam02065 767468008358 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 767468008359 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 767468008360 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 767468008361 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 767468008362 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 767468008363 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 767468008364 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 767468008365 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 767468008366 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 767468008367 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 767468008368 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 767468008369 HPr interaction site; other site 767468008370 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767468008371 active site 767468008372 phosphorylation site [posttranslational modification] 767468008373 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 767468008374 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 767468008375 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 767468008376 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767468008377 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 767468008378 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 767468008379 catalytic triad [active] 767468008380 putative active site [active] 767468008381 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 767468008382 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 767468008383 Active site serine [active] 767468008384 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767468008385 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468008386 non-specific DNA binding site [nucleotide binding]; other site 767468008387 salt bridge; other site 767468008388 sequence-specific DNA binding site [nucleotide binding]; other site 767468008389 FRG domain; Region: FRG; pfam08867 767468008390 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767468008391 MULE transposase domain; Region: MULE; pfam10551 767468008392 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468008393 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468008394 Integrase core domain; Region: rve; pfam00665 767468008395 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767468008396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767468008397 dimerization interface [polypeptide binding]; other site 767468008398 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767468008399 DNA binding site [nucleotide binding] 767468008400 K+ potassium transporter; Region: K_trans; pfam02705 767468008401 MarR family; Region: MarR; pfam01047 767468008402 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 767468008403 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 767468008404 catalytic residues [active] 767468008405 catalytic nucleophile [active] 767468008406 Presynaptic Site I dimer interface [polypeptide binding]; other site 767468008407 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 767468008408 Synaptic Flat tetramer interface [polypeptide binding]; other site 767468008409 Synaptic Site I dimer interface [polypeptide binding]; other site 767468008410 DNA binding site [nucleotide binding] 767468008411 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767468008412 Ligand Binding Site [chemical binding]; other site 767468008413 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 767468008414 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 767468008415 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 767468008416 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 767468008417 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 767468008418 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 767468008419 Integrase core domain; Region: rve; pfam00665 767468008420 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 767468008421 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767468008422 P-loop; other site 767468008423 Magnesium ion binding site [ion binding]; other site 767468008424 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767468008425 Magnesium ion binding site [ion binding]; other site 767468008426 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468008427 Integrase core domain; Region: rve; pfam00665 767468008428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 767468008429 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468008430 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468008431 Integrase core domain; Region: rve; pfam00665 767468008432 MobA/MobL family; Region: MobA_MobL; pfam03389 767468008433 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 767468008434 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767468008435 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767468008436 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767468008437 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767468008438 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767468008439 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767468008440 dimerization interface [polypeptide binding]; other site 767468008441 FAD binding domain; Region: FAD_binding_2; pfam00890 767468008442 FMN-binding domain; Region: FMN_bind; pfam04205 767468008443 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 767468008444 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 767468008445 transmembrane helices; other site 767468008446 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 767468008447 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 767468008448 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767468008449 MULE transposase domain; Region: MULE; pfam10551 767468008450 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 767468008451 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 767468008452 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468008453 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468008454 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767468008455 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468008456 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468008457 Integrase core domain; Region: rve; pfam00665 767468008458 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 767468008459 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767468008460 P-loop; other site 767468008461 Magnesium ion binding site [ion binding]; other site 767468008462 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767468008463 Magnesium ion binding site [ion binding]; other site 767468008464 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468008465 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468008466 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 767468008467 xanthine permease; Region: pbuX; TIGR03173 767468008468 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 767468008469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767468008470 SlyX; Region: SlyX; cl01090 767468008471 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 767468008472 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468008473 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468008474 RelB antitoxin; Region: RelB; cl01171 767468008475 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 767468008476 MobA/MobL family; Region: MobA_MobL; pfam03389 767468008477 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 767468008478 DNA topoisomerase III; Provisional; Region: PRK07726 767468008479 active site 767468008480 putative interdomain interaction site [polypeptide binding]; other site 767468008481 putative metal-binding site [ion binding]; other site 767468008482 putative nucleotide binding site [chemical binding]; other site 767468008483 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 767468008484 domain I; other site 767468008485 DNA binding groove [nucleotide binding] 767468008486 phosphate binding site [ion binding]; other site 767468008487 domain II; other site 767468008488 domain III; other site 767468008489 nucleotide binding site [chemical binding]; other site 767468008490 catalytic site [active] 767468008491 domain IV; other site 767468008492 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 767468008493 Integrase core domain; Region: rve; pfam00665 767468008494 Domain of unknown function (DUF955); Region: DUF955; cl01076 767468008495 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 767468008496 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 767468008497 Integrase core domain; Region: rve; pfam00665 767468008498 Acetokinase family; Region: Acetate_kinase; cl17229 767468008499 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 767468008500 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767468008501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767468008502 homodimer interface [polypeptide binding]; other site 767468008503 catalytic residue [active] 767468008504 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 767468008505 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 767468008506 TrkA-C domain; Region: TrkA_C; pfam02080 767468008507 TrkA-C domain; Region: TrkA_C; pfam02080 767468008508 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 767468008509 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 767468008510 Integrase core domain; Region: rve; pfam00665 767468008511 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 767468008512 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 767468008513 catalytic residues [active] 767468008514 catalytic nucleophile [active] 767468008515 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468008516 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468008517 Predicted integral membrane protein [Function unknown]; Region: COG5617 767468008518 Initiator Replication protein; Region: Rep_3; cl17676 767468008519 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 767468008520 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 767468008521 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767468008522 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 767468008523 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767468008524 active site 767468008525 motif I; other site 767468008526 motif II; other site 767468008527 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 767468008528 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 767468008529 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 767468008530 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767468008531 salt bridge; other site 767468008532 non-specific DNA binding site [nucleotide binding]; other site 767468008533 sequence-specific DNA binding site [nucleotide binding]; other site 767468008534 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 767468008535 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767468008536 active site 767468008537 DNA binding site [nucleotide binding] 767468008538 Int/Topo IB signature motif; other site 767468008539 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 767468008540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 767468008541 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 767468008542 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468008543 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468008544 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 767468008545 active site 767468008546 PemK-like protein; Region: PemK; pfam02452 767468008547 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 767468008548 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767468008549 active site 767468008550 DNA binding site [nucleotide binding] 767468008551 Int/Topo IB signature motif; other site 767468008552 Initiator Replication protein; Region: Rep_3; pfam01051 767468008553 HTH domain; Region: HTH_11; cl17392 767468008554 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 767468008555 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 767468008556 dimerization interface [polypeptide binding]; other site 767468008557 DPS ferroxidase diiron center [ion binding]; other site 767468008558 ion pore; other site 767468008559 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468008560 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468008561 Integrase core domain; Region: rve; pfam00665 767468008562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468008563 dimer interface [polypeptide binding]; other site 767468008564 conserved gate region; other site 767468008565 putative PBP binding loops; other site 767468008566 ABC-ATPase subunit interface; other site 767468008567 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 767468008568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767468008569 dimer interface [polypeptide binding]; other site 767468008570 conserved gate region; other site 767468008571 putative PBP binding loops; other site 767468008572 ABC-ATPase subunit interface; other site 767468008573 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767468008574 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767468008575 Walker A/P-loop; other site 767468008576 ATP binding site [chemical binding]; other site 767468008577 Q-loop/lid; other site 767468008578 ABC transporter signature motif; other site 767468008579 Walker B; other site 767468008580 D-loop; other site 767468008581 H-loop/switch region; other site 767468008582 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 767468008583 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767468008584 substrate binding pocket [chemical binding]; other site 767468008585 membrane-bound complex binding site; other site 767468008586 hinge residues; other site 767468008587 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468008588 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468008589 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 767468008590 PemK-like protein; Region: PemK; pfam02452 767468008591 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 767468008592 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 767468008593 Int/Topo IB signature motif; other site 767468008594 Protein of unknown function, DUF536; Region: DUF536; pfam04394 767468008595 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468008596 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468008597 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 767468008598 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 767468008599 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 767468008600 YKOF-related Family; Region: Ykof; pfam07615 767468008601 YKOF-related Family; Region: Ykof; pfam07615 767468008602 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468008603 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468008604 Integrase core domain; Region: rve; pfam00665 767468008605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 767468008606 HTH-like domain; Region: HTH_21; pfam13276 767468008607 Integrase core domain; Region: rve; pfam00665 767468008608 Integrase core domain; Region: rve_3; cl15866 767468008609 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767468008610 Transposase; Region: HTH_Tnp_1; pfam01527 767468008611 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 767468008612 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 767468008613 catalytic residues [active] 767468008614 catalytic nucleophile [active] 767468008615 Presynaptic Site I dimer interface [polypeptide binding]; other site 767468008616 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 767468008617 Synaptic Flat tetramer interface [polypeptide binding]; other site 767468008618 Synaptic Site I dimer interface [polypeptide binding]; other site 767468008619 DNA binding site [nucleotide binding] 767468008620 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767468008621 Ligand Binding Site [chemical binding]; other site 767468008622 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 767468008623 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 767468008624 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 767468008625 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 767468008626 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 767468008627 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 767468008628 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468008629 Integrase core domain; Region: rve; pfam00665 767468008630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 767468008631 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468008632 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468008633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468008634 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 767468008635 putative substrate translocation pore; other site 767468008636 multicopper oxidase; Provisional; Region: PRK10965 767468008637 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 767468008638 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 767468008639 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468008640 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468008641 Integrase core domain; Region: rve; pfam00665 767468008642 Winged helix-turn helix; Region: HTH_29; pfam13551 767468008643 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468008644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767468008645 Helix-turn-helix domain; Region: HTH_28; pfam13518 767468008646 putative transposase OrfB; Reviewed; Region: PHA02517 767468008647 HTH-like domain; Region: HTH_21; pfam13276 767468008648 Integrase core domain; Region: rve; pfam00665 767468008649 Integrase core domain; Region: rve_2; pfam13333 767468008650 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 767468008651 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767468008652 Magnesium ion binding site [ion binding]; other site 767468008653 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 767468008654 Dimer interface [polypeptide binding]; other site 767468008655 BRCT sequence motif; other site 767468008656 Bacteriophage holin; Region: Phage_holin_1; cl02344 767468008657 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 767468008658 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 767468008659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 767468008660 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 767468008661 MobA/MobL family; Region: MobA_MobL; pfam03389 767468008662 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 767468008663 domain I; other site 767468008664 phosphate binding site [ion binding]; other site 767468008665 domain III; other site 767468008666 nucleotide binding site [chemical binding]; other site 767468008667 catalytic site [active] 767468008668 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468008669 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468008670 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 767468008671 DNA-binding site [nucleotide binding]; DNA binding site 767468008672 RNA-binding motif; other site 767468008673 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468008674 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468008675 Integrase core domain; Region: rve; pfam00665 767468008676 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 767468008677 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 767468008678 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 767468008679 UbiA prenyltransferase family; Region: UbiA; pfam01040 767468008680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767468008681 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468008682 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468008683 MarR family; Region: MarR; pfam01047 767468008684 K+ potassium transporter; Region: K_trans; pfam02705 767468008685 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767468008686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767468008687 dimerization interface [polypeptide binding]; other site 767468008688 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767468008689 DNA binding site [nucleotide binding] 767468008690 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767468008691 Helix-turn-helix domain; Region: HTH_38; pfam13936 767468008692 Integrase core domain; Region: rve; pfam00665 767468008693 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 767468008694 DNA-binding site [nucleotide binding]; DNA binding site 767468008695 RNA-binding motif; other site 767468008696 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767468008697 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767468008698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 767468008699 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 767468008700 MobA/MobL family; Region: MobA_MobL; pfam03389 767468008701 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 767468008702 DNA topoisomerase III; Provisional; Region: PRK07726 767468008703 active site 767468008704 putative interdomain interaction site [polypeptide binding]; other site 767468008705 putative metal-binding site [ion binding]; other site 767468008706 putative nucleotide binding site [chemical binding]; other site 767468008707 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 767468008708 domain I; other site 767468008709 DNA binding groove [nucleotide binding] 767468008710 phosphate binding site [ion binding]; other site 767468008711 domain II; other site 767468008712 domain III; other site 767468008713 nucleotide binding site [chemical binding]; other site 767468008714 catalytic site [active] 767468008715 domain IV; other site 767468008716 Domain of unknown function (DUF955); Region: DUF955; cl01076 767468008717 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 767468008718 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 767468008719 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 767468008720 HsdM N-terminal domain; Region: HsdM_N; pfam12161 767468008721 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 767468008722 Methyltransferase domain; Region: Methyltransf_26; pfam13659 767468008723 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 767468008724 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 767468008725 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767468008726 ATP binding site [chemical binding]; other site 767468008727 putative Mg++ binding site [ion binding]; other site 767468008728 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 767468008729 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 767468008730 catalytic residues [active] 767468008731 catalytic nucleophile [active] 767468008732 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 767468008733 Penicillinase repressor; Region: Pencillinase_R; pfam03965