-- dump date 20140619_124218 -- class Genbank::misc_feature -- table misc_feature_note -- id note 220668000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 220668000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 220668000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668000004 Walker A motif; other site 220668000005 ATP binding site [chemical binding]; other site 220668000006 Walker B motif; other site 220668000007 arginine finger; other site 220668000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 220668000009 DnaA box-binding interface [nucleotide binding]; other site 220668000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 220668000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 220668000012 putative DNA binding surface [nucleotide binding]; other site 220668000013 dimer interface [polypeptide binding]; other site 220668000014 beta-clamp/clamp loader binding surface; other site 220668000015 beta-clamp/translesion DNA polymerase binding surface; other site 220668000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 220668000017 RNA binding surface [nucleotide binding]; other site 220668000018 recombination protein F; Reviewed; Region: recF; PRK00064 220668000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 220668000020 Walker A/P-loop; other site 220668000021 ATP binding site [chemical binding]; other site 220668000022 Q-loop/lid; other site 220668000023 ABC transporter signature motif; other site 220668000024 Walker B; other site 220668000025 D-loop; other site 220668000026 H-loop/switch region; other site 220668000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 220668000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 220668000029 ATP binding site [chemical binding]; other site 220668000030 Mg2+ binding site [ion binding]; other site 220668000031 G-X-G motif; other site 220668000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 220668000033 anchoring element; other site 220668000034 dimer interface [polypeptide binding]; other site 220668000035 ATP binding site [chemical binding]; other site 220668000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 220668000037 active site 220668000038 putative metal-binding site [ion binding]; other site 220668000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 220668000040 DNA gyrase subunit A; Validated; Region: PRK05560 220668000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 220668000042 CAP-like domain; other site 220668000043 active site 220668000044 primary dimer interface [polypeptide binding]; other site 220668000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 220668000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 220668000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 220668000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 220668000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 220668000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 220668000051 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 220668000052 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 220668000053 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 220668000054 dimer interface [polypeptide binding]; other site 220668000055 ssDNA binding site [nucleotide binding]; other site 220668000056 tetramer (dimer of dimers) interface [polypeptide binding]; other site 220668000057 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 220668000058 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 220668000059 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 220668000060 metal binding site [ion binding]; metal-binding site 220668000061 DHH family; Region: DHH; pfam01368 220668000062 DHHA1 domain; Region: DHHA1; pfam02272 220668000063 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 220668000064 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 220668000065 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 220668000066 replicative DNA helicase; Provisional; Region: PRK05748 220668000067 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 220668000068 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 220668000069 Walker A motif; other site 220668000070 ATP binding site [chemical binding]; other site 220668000071 Walker B motif; other site 220668000072 DNA binding loops [nucleotide binding] 220668000073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668000074 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668000075 putative substrate translocation pore; other site 220668000076 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 220668000077 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 220668000078 nucleotide binding site [chemical binding]; other site 220668000079 homotetrameric interface [polypeptide binding]; other site 220668000080 putative phosphate binding site [ion binding]; other site 220668000081 putative allosteric binding site; other site 220668000082 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 220668000083 putative catalytic cysteine [active] 220668000084 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 220668000085 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 220668000086 peptide binding site [polypeptide binding]; other site 220668000087 glycogen branching enzyme; Provisional; Region: PRK12313 220668000088 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 220668000089 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 220668000090 active site 220668000091 catalytic site [active] 220668000092 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 220668000093 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 220668000094 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 220668000095 ligand binding site; other site 220668000096 oligomer interface; other site 220668000097 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 220668000098 dimer interface [polypeptide binding]; other site 220668000099 N-terminal domain interface [polypeptide binding]; other site 220668000100 sulfate 1 binding site; other site 220668000101 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 220668000102 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 220668000103 ligand binding site; other site 220668000104 oligomer interface; other site 220668000105 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 220668000106 dimer interface [polypeptide binding]; other site 220668000107 N-terminal domain interface [polypeptide binding]; other site 220668000108 sulfate 1 binding site; other site 220668000109 glycogen synthase; Provisional; Region: glgA; PRK00654 220668000110 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 220668000111 ADP-binding pocket [chemical binding]; other site 220668000112 homodimer interface [polypeptide binding]; other site 220668000113 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 220668000114 homodimer interface [polypeptide binding]; other site 220668000115 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 220668000116 active site pocket [active] 220668000117 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 220668000118 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 220668000119 active site 220668000120 homodimer interface [polypeptide binding]; other site 220668000121 catalytic site [active] 220668000122 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 220668000123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668000124 active site 220668000125 motif I; other site 220668000126 motif II; other site 220668000127 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 220668000128 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 220668000129 beta-phosphoglucomutase; Region: bPGM; TIGR01990 220668000130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668000131 motif II; other site 220668000132 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 220668000133 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 220668000134 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 220668000135 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 220668000136 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 220668000137 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 220668000138 DNA-binding site [nucleotide binding]; DNA binding site 220668000139 RNA-binding motif; other site 220668000140 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 220668000141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 220668000142 active site 220668000143 phosphorylation site [posttranslational modification] 220668000144 intermolecular recognition site; other site 220668000145 dimerization interface [polypeptide binding]; other site 220668000146 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 220668000147 DNA binding site [nucleotide binding] 220668000148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 220668000149 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 220668000150 dimerization interface [polypeptide binding]; other site 220668000151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 220668000152 putative active site [active] 220668000153 heme pocket [chemical binding]; other site 220668000154 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 220668000155 dimer interface [polypeptide binding]; other site 220668000156 phosphorylation site [posttranslational modification] 220668000157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 220668000158 ATP binding site [chemical binding]; other site 220668000159 Mg2+ binding site [ion binding]; other site 220668000160 G-X-G motif; other site 220668000161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 220668000162 YycH protein; Region: YycH; pfam07435 220668000163 YycH protein; Region: YycI; pfam09648 220668000164 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 220668000165 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 220668000166 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 220668000167 protein binding site [polypeptide binding]; other site 220668000168 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 220668000169 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668000170 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 220668000171 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 220668000172 NAD(P) binding site [chemical binding]; other site 220668000173 catalytic residues [active] 220668000174 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 220668000175 putative uracil binding site [chemical binding]; other site 220668000176 putative active site [active] 220668000177 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 220668000178 putative FMN binding site [chemical binding]; other site 220668000179 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 220668000180 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 220668000181 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 220668000182 Predicted flavoprotein [General function prediction only]; Region: COG0431 220668000183 hypothetical protein; Provisional; Region: PRK12839 220668000184 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668000185 FMN-binding domain; Region: FMN_bind; cl01081 220668000186 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 220668000187 anion transporter; Region: dass; TIGR00785 220668000188 transmembrane helices; other site 220668000189 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668000190 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668000191 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 220668000192 dimerization interface [polypeptide binding]; other site 220668000193 flavodoxin; Provisional; Region: PRK06242 220668000194 Low molecular weight phosphatase family; Region: LMWPc; cd00115 220668000195 active site 220668000196 hypothetical protein; Provisional; Region: PRK06194 220668000197 classical (c) SDRs; Region: SDR_c; cd05233 220668000198 NAD(P) binding site [chemical binding]; other site 220668000199 active site 220668000200 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 220668000201 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 220668000202 dimer interface [polypeptide binding]; other site 220668000203 FMN binding site [chemical binding]; other site 220668000204 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 220668000205 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 220668000206 beta-phosphoglucomutase; Region: bPGM; TIGR01990 220668000207 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668000208 motif II; other site 220668000209 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 220668000210 active site 220668000211 Uncharacterized conserved protein [Function unknown]; Region: COG2966 220668000212 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 220668000213 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 220668000214 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 220668000215 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 220668000216 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 220668000217 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 220668000218 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 220668000219 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 220668000220 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 220668000221 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 220668000222 catalytic triad [active] 220668000223 Predicted transcriptional regulator [Transcription]; Region: COG2378 220668000224 HTH domain; Region: HTH_11; pfam08279 220668000225 WYL domain; Region: WYL; pfam13280 220668000226 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 220668000227 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 220668000228 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 220668000229 G1 box; other site 220668000230 putative GEF interaction site [polypeptide binding]; other site 220668000231 GTP/Mg2+ binding site [chemical binding]; other site 220668000232 Switch I region; other site 220668000233 G2 box; other site 220668000234 G3 box; other site 220668000235 Switch II region; other site 220668000236 G4 box; other site 220668000237 G5 box; other site 220668000238 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 220668000239 Elongation Factor G, domain II; Region: EFG_II; pfam14492 220668000240 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 220668000241 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 220668000242 Protein of unknown function; Region: DUF3658; pfam12395 220668000243 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 220668000244 EamA-like transporter family; Region: EamA; pfam00892 220668000245 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 220668000246 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668000247 Coenzyme A binding pocket [chemical binding]; other site 220668000248 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 220668000249 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 220668000250 potential catalytic triad [active] 220668000251 conserved cys residue [active] 220668000252 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 220668000253 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 220668000254 putative NAD(P) binding site [chemical binding]; other site 220668000255 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 220668000256 dimerization interface [polypeptide binding]; other site 220668000257 putative DNA binding site [nucleotide binding]; other site 220668000258 putative Zn2+ binding site [ion binding]; other site 220668000259 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 220668000260 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 220668000261 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 220668000262 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668000263 hypothetical protein; Validated; Region: PRK02101 220668000264 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 220668000265 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 220668000266 peptide binding site [polypeptide binding]; other site 220668000267 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 220668000268 active site 220668000269 NTP binding site [chemical binding]; other site 220668000270 metal binding triad [ion binding]; metal-binding site 220668000271 antibiotic binding site [chemical binding]; other site 220668000272 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 220668000273 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 220668000274 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 220668000275 Walker A/P-loop; other site 220668000276 ATP binding site [chemical binding]; other site 220668000277 Q-loop/lid; other site 220668000278 ABC transporter signature motif; other site 220668000279 Walker B; other site 220668000280 D-loop; other site 220668000281 H-loop/switch region; other site 220668000282 Cobalt transport protein; Region: CbiQ; cl00463 220668000283 cobalt transport protein CbiM; Provisional; Region: PRK07331 220668000284 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 220668000285 PDGLE domain; Region: PDGLE; pfam13190 220668000286 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 220668000287 putative switch regulator; other site 220668000288 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 220668000289 non-specific DNA interactions [nucleotide binding]; other site 220668000290 DNA binding site [nucleotide binding] 220668000291 sequence specific DNA binding site [nucleotide binding]; other site 220668000292 putative cAMP binding site [chemical binding]; other site 220668000293 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 220668000294 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 220668000295 AIR carboxylase; Region: AIRC; smart01001 220668000296 Protein of unknown function DUF111; Region: DUF111; cl03398 220668000297 Protein of unknown function DUF111; Region: DUF111; cl03398 220668000298 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 220668000299 amphipathic channel; other site 220668000300 Asn-Pro-Ala signature motifs; other site 220668000301 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 220668000302 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 220668000303 Ligand Binding Site [chemical binding]; other site 220668000304 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 220668000305 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 220668000306 putative NAD(P) binding site [chemical binding]; other site 220668000307 substrate binding site [chemical binding]; other site 220668000308 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 220668000309 substrate binding site [chemical binding]; other site 220668000310 multimerization interface [polypeptide binding]; other site 220668000311 ATP binding site [chemical binding]; other site 220668000312 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 220668000313 dimer interface [polypeptide binding]; other site 220668000314 substrate binding site [chemical binding]; other site 220668000315 ATP binding site [chemical binding]; other site 220668000316 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 220668000317 thiamine phosphate binding site [chemical binding]; other site 220668000318 active site 220668000319 pyrophosphate binding site [ion binding]; other site 220668000320 putative hydroxymethylpyrimidine transporter CytX; Region: thia_cytX; TIGR02358 220668000321 Na binding site [ion binding]; other site 220668000322 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 220668000323 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 220668000324 catalytic triad [active] 220668000325 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 220668000326 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 220668000327 nudix motif; other site 220668000328 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 220668000329 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 220668000330 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668000331 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 220668000332 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 220668000333 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 220668000334 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 220668000335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668000336 motif II; other site 220668000337 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 220668000338 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 220668000339 PspC domain; Region: PspC; pfam04024 220668000340 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 220668000341 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 220668000342 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668000343 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 220668000344 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 220668000345 putative dimer interface [polypeptide binding]; other site 220668000346 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 220668000347 LytTr DNA-binding domain; Region: LytTR; smart00850 220668000348 drug efflux system protein MdtG; Provisional; Region: PRK09874 220668000349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668000350 putative substrate translocation pore; other site 220668000351 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 220668000352 dimerization interface [polypeptide binding]; other site 220668000353 putative DNA binding site [nucleotide binding]; other site 220668000354 putative Zn2+ binding site [ion binding]; other site 220668000355 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 220668000356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668000357 putative substrate translocation pore; other site 220668000358 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 220668000359 active site 220668000360 catalytic tetrad [active] 220668000361 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 220668000362 active site 220668000363 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 220668000364 catalytic tetrad [active] 220668000365 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 220668000366 myosin-cross-reactive antigen; Provisional; Region: PRK13977 220668000367 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; pfam06100 220668000368 adenylate kinase; Provisional; Region: PRK13808 220668000369 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 220668000370 putative active site [active] 220668000371 putative FMN binding site [chemical binding]; other site 220668000372 putative substrate binding site [chemical binding]; other site 220668000373 putative catalytic residue [active] 220668000374 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 220668000375 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 220668000376 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 220668000377 Walker A/P-loop; other site 220668000378 ATP binding site [chemical binding]; other site 220668000379 Q-loop/lid; other site 220668000380 ABC transporter signature motif; other site 220668000381 Walker B; other site 220668000382 D-loop; other site 220668000383 H-loop/switch region; other site 220668000384 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 220668000385 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 220668000386 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 220668000387 Walker A/P-loop; other site 220668000388 ATP binding site [chemical binding]; other site 220668000389 Q-loop/lid; other site 220668000390 ABC transporter signature motif; other site 220668000391 Walker B; other site 220668000392 D-loop; other site 220668000393 H-loop/switch region; other site 220668000394 hypothetical protein; Provisional; Region: PRK13661 220668000395 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 220668000396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668000397 DNA-binding site [nucleotide binding]; DNA binding site 220668000398 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 220668000399 Transcriptional regulator PadR-like family; Region: PadR; cl17335 220668000400 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 220668000401 classical (c) SDRs; Region: SDR_c; cd05233 220668000402 NAD(P) binding site [chemical binding]; other site 220668000403 active site 220668000404 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 220668000405 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 220668000406 Walker A/P-loop; other site 220668000407 ATP binding site [chemical binding]; other site 220668000408 Q-loop/lid; other site 220668000409 ABC transporter signature motif; other site 220668000410 Walker B; other site 220668000411 D-loop; other site 220668000412 H-loop/switch region; other site 220668000413 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 220668000414 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 220668000415 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668000416 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 220668000417 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 220668000418 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 220668000419 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 220668000420 active site 220668000421 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 220668000422 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 220668000423 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 220668000424 probable dihydroxyacetone kinase DhaK1b subunit; Region: dhaK1b; TIGR02362 220668000425 dihydroxyacetone kinase, DhaK subunit; Region: dhaK1; TIGR02363 220668000426 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 220668000427 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 220668000428 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 220668000429 amphipathic channel; other site 220668000430 Asn-Pro-Ala signature motifs; other site 220668000431 Transcriptional regulators [Transcription]; Region: PurR; COG1609 220668000432 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 220668000433 DNA binding site [nucleotide binding] 220668000434 domain linker motif; other site 220668000435 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 220668000436 putative dimerization interface [polypeptide binding]; other site 220668000437 putative ligand binding site [chemical binding]; other site 220668000438 Transcriptional regulators [Transcription]; Region: PurR; COG1609 220668000439 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 220668000440 DNA binding site [nucleotide binding] 220668000441 domain linker motif; other site 220668000442 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 220668000443 ligand binding site [chemical binding]; other site 220668000444 dimerization interface [polypeptide binding]; other site 220668000445 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 220668000446 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 220668000447 Ca binding site [ion binding]; other site 220668000448 active site 220668000449 catalytic site [active] 220668000450 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 220668000451 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 220668000452 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 220668000453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668000454 dimer interface [polypeptide binding]; other site 220668000455 conserved gate region; other site 220668000456 putative PBP binding loops; other site 220668000457 ABC-ATPase subunit interface; other site 220668000458 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 220668000459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668000460 dimer interface [polypeptide binding]; other site 220668000461 conserved gate region; other site 220668000462 putative PBP binding loops; other site 220668000463 ABC-ATPase subunit interface; other site 220668000464 Predicted integral membrane protein [Function unknown]; Region: COG5521 220668000465 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 220668000466 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 220668000467 active site 220668000468 catalytic site [active] 220668000469 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 220668000470 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 220668000471 Walker A/P-loop; other site 220668000472 ATP binding site [chemical binding]; other site 220668000473 Q-loop/lid; other site 220668000474 ABC transporter signature motif; other site 220668000475 Walker B; other site 220668000476 D-loop; other site 220668000477 H-loop/switch region; other site 220668000478 TOBE domain; Region: TOBE_2; pfam08402 220668000479 maltose phosphorylase; Provisional; Region: PRK13807 220668000480 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 220668000481 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 220668000482 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 220668000483 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 220668000484 putative active site [active] 220668000485 FOG: PKD repeat [General function prediction only]; Region: COG3291 220668000486 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 220668000487 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 220668000488 sugar binding site [chemical binding]; other site 220668000489 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 220668000490 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 220668000491 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 220668000492 nucleotide binding site [chemical binding]; other site 220668000493 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 220668000494 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 220668000495 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 220668000496 active site turn [active] 220668000497 phosphorylation site [posttranslational modification] 220668000498 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 220668000499 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 220668000500 HPr interaction site; other site 220668000501 glycerol kinase (GK) interaction site [polypeptide binding]; other site 220668000502 active site 220668000503 phosphorylation site [posttranslational modification] 220668000504 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 220668000505 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 220668000506 substrate binding [chemical binding]; other site 220668000507 active site 220668000508 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 220668000509 Transcriptional regulators [Transcription]; Region: PurR; COG1609 220668000510 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 220668000511 DNA binding site [nucleotide binding] 220668000512 domain linker motif; other site 220668000513 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 220668000514 dimerization interface [polypeptide binding]; other site 220668000515 ligand binding site [chemical binding]; other site 220668000516 sodium binding site [ion binding]; other site 220668000517 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 220668000518 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 220668000519 Ca binding site [ion binding]; other site 220668000520 active site 220668000521 catalytic site [active] 220668000522 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 220668000523 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 220668000524 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 220668000525 putative NAD(P) binding site [chemical binding]; other site 220668000526 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 220668000527 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 220668000528 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 220668000529 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 220668000530 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 220668000531 Ca binding site [ion binding]; other site 220668000532 active site 220668000533 catalytic site [active] 220668000534 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 220668000535 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668000536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668000537 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 220668000538 dimerization interface [polypeptide binding]; other site 220668000539 Cna protein B-type domain; Region: Cna_B; pfam05738 220668000540 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 220668000541 domain interaction interfaces [polypeptide binding]; other site 220668000542 Cna protein B-type domain; Region: Cna_B; pfam05738 220668000543 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668000544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668000545 non-specific DNA binding site [nucleotide binding]; other site 220668000546 salt bridge; other site 220668000547 sequence-specific DNA binding site [nucleotide binding]; other site 220668000548 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 220668000549 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 220668000550 peptide binding site [polypeptide binding]; other site 220668000551 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 220668000552 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 220668000553 peptide binding site [polypeptide binding]; other site 220668000554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 220668000555 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 220668000556 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 220668000557 putative ligand binding site [chemical binding]; other site 220668000558 putative NAD binding site [chemical binding]; other site 220668000559 putative catalytic site [active] 220668000560 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 220668000561 L-serine binding site [chemical binding]; other site 220668000562 ACT domain interface; other site 220668000563 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 220668000564 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 220668000565 catalytic residue [active] 220668000566 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 220668000567 catalytic core [active] 220668000568 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 220668000569 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 220668000570 active site 220668000571 catalytic tetrad [active] 220668000572 Cytochrome c; Region: Cytochrom_C; cl11414 220668000573 Domain of unknown function (DU1801); Region: DUF1801; cl17490 220668000574 Domain of unknown function (DUF814); Region: DUF814; pfam05670 220668000575 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 220668000576 CrcB-like protein; Region: CRCB; cl09114 220668000577 CrcB-like protein; Region: CRCB; cl09114 220668000578 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 220668000579 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 220668000580 ABC transporter; Region: ABC_tran_2; pfam12848 220668000581 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 220668000582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 220668000583 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 220668000584 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 220668000585 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 220668000586 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 220668000587 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 220668000588 Walker A/P-loop; other site 220668000589 ATP binding site [chemical binding]; other site 220668000590 Q-loop/lid; other site 220668000591 ABC transporter signature motif; other site 220668000592 Walker B; other site 220668000593 D-loop; other site 220668000594 H-loop/switch region; other site 220668000595 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 220668000596 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 220668000597 Walker A/P-loop; other site 220668000598 ATP binding site [chemical binding]; other site 220668000599 Q-loop/lid; other site 220668000600 ABC transporter signature motif; other site 220668000601 Walker B; other site 220668000602 D-loop; other site 220668000603 H-loop/switch region; other site 220668000604 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 220668000605 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 220668000606 catalytic residues [active] 220668000607 dimer interface [polypeptide binding]; other site 220668000608 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 220668000609 active site 220668000610 catalytic tetrad [active] 220668000611 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 220668000612 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 220668000613 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 220668000614 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668000615 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668000616 non-specific DNA binding site [nucleotide binding]; other site 220668000617 salt bridge; other site 220668000618 sequence-specific DNA binding site [nucleotide binding]; other site 220668000619 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 220668000620 active site 220668000621 trimer interface [polypeptide binding]; other site 220668000622 allosteric site; other site 220668000623 active site lid [active] 220668000624 hexamer (dimer of trimers) interface [polypeptide binding]; other site 220668000625 Peptidase family C69; Region: Peptidase_C69; pfam03577 220668000626 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 220668000627 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 220668000628 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 220668000629 active site 220668000630 P-loop; other site 220668000631 phosphorylation site [posttranslational modification] 220668000632 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 220668000633 active site 220668000634 P-loop; other site 220668000635 phosphorylation site [posttranslational modification] 220668000636 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 220668000637 PRD domain; Region: PRD; pfam00874 220668000638 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 220668000639 active site 220668000640 P-loop; other site 220668000641 phosphorylation site [posttranslational modification] 220668000642 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 220668000643 active site 220668000644 phosphorylation site [posttranslational modification] 220668000645 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 220668000646 active site 220668000647 phosphorylation site [posttranslational modification] 220668000648 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 220668000649 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 220668000650 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 220668000651 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 220668000652 DNA binding residues [nucleotide binding] 220668000653 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 220668000654 catalytic residues [active] 220668000655 Nucleoside diphosphate kinase; Region: NDK; pfam00334 220668000656 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 220668000657 active site 220668000658 multimer interface [polypeptide binding]; other site 220668000659 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 220668000660 Predicted flavoprotein [General function prediction only]; Region: COG0431 220668000661 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 220668000662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668000663 DNA-binding site [nucleotide binding]; DNA binding site 220668000664 UTRA domain; Region: UTRA; pfam07702 220668000665 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 220668000666 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 220668000667 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 220668000668 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 220668000669 active site 220668000670 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 220668000671 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 220668000672 catalytic residue [active] 220668000673 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 220668000674 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 220668000675 substrate binding site [chemical binding]; other site 220668000676 ATP binding site [chemical binding]; other site 220668000677 serine O-acetyltransferase; Region: cysE; TIGR01172 220668000678 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 220668000679 trimer interface [polypeptide binding]; other site 220668000680 active site 220668000681 substrate binding site [chemical binding]; other site 220668000682 CoA binding site [chemical binding]; other site 220668000683 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 220668000684 homodimer interface [polypeptide binding]; other site 220668000685 substrate-cofactor binding pocket; other site 220668000686 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668000687 catalytic residue [active] 220668000688 cysteine synthase; Region: PLN02565 220668000689 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 220668000690 dimer interface [polypeptide binding]; other site 220668000691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668000692 catalytic residue [active] 220668000693 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 220668000694 active site 220668000695 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 220668000696 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 220668000697 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 220668000698 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668000699 DNA-binding site [nucleotide binding]; DNA binding site 220668000700 UTRA domain; Region: UTRA; pfam07702 220668000701 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 220668000702 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 220668000703 Ca binding site [ion binding]; other site 220668000704 active site 220668000705 catalytic site [active] 220668000706 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 220668000707 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 220668000708 HPr interaction site; other site 220668000709 glycerol kinase (GK) interaction site [polypeptide binding]; other site 220668000710 active site 220668000711 phosphorylation site [posttranslational modification] 220668000712 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 220668000713 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 220668000714 active site turn [active] 220668000715 phosphorylation site [posttranslational modification] 220668000716 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 220668000717 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 220668000718 HPr interaction site; other site 220668000719 glycerol kinase (GK) interaction site [polypeptide binding]; other site 220668000720 active site 220668000721 phosphorylation site [posttranslational modification] 220668000722 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 220668000723 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 220668000724 active site turn [active] 220668000725 phosphorylation site [posttranslational modification] 220668000726 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 220668000727 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 220668000728 active site 220668000729 nucleotide binding site [chemical binding]; other site 220668000730 HIGH motif; other site 220668000731 KMSKS motif; other site 220668000732 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 220668000733 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 220668000734 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 220668000735 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 220668000736 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 220668000737 putative ADP-binding pocket [chemical binding]; other site 220668000738 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 220668000739 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 220668000740 Archaeal flavoproteins [Energy production and conversion]; Region: COG1036 220668000741 Predicted transcriptional regulator [Transcription]; Region: COG1959 220668000742 Rrf2 family protein; Region: rrf2_super; TIGR00738 220668000743 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668000744 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 220668000745 manganese transport protein MntH; Reviewed; Region: PRK00701 220668000746 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 220668000747 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 220668000748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668000749 putative substrate translocation pore; other site 220668000750 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 220668000751 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 220668000752 DNA binding residues [nucleotide binding] 220668000753 putative dimer interface [polypeptide binding]; other site 220668000754 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 220668000755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 220668000756 dimer interface [polypeptide binding]; other site 220668000757 phosphorylation site [posttranslational modification] 220668000758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 220668000759 ATP binding site [chemical binding]; other site 220668000760 Mg2+ binding site [ion binding]; other site 220668000761 G-X-G motif; other site 220668000762 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 220668000763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 220668000764 active site 220668000765 phosphorylation site [posttranslational modification] 220668000766 intermolecular recognition site; other site 220668000767 dimerization interface [polypeptide binding]; other site 220668000768 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 220668000769 DNA binding site [nucleotide binding] 220668000770 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 220668000771 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 220668000772 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 220668000773 putative active site [active] 220668000774 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 220668000775 Bacteriophage Mu transposase; Region: DDE_2; pfam02914 220668000776 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 220668000777 FAD binding domain; Region: FAD_binding_4; pfam01565 220668000778 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 220668000779 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 220668000780 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 220668000781 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 220668000782 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 220668000783 synthetase active site [active] 220668000784 NTP binding site [chemical binding]; other site 220668000785 metal binding site [ion binding]; metal-binding site 220668000786 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 220668000787 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 220668000788 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 220668000789 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 220668000790 MMPL family; Region: MMPL; cl14618 220668000791 Predicted membrane protein [Function unknown]; Region: COG1511 220668000792 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913 220668000793 MMPL family; Region: MMPL; cl14618 220668000794 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 220668000795 legume lectins; Region: lectin_L-type; cl14058 220668000796 homotetramer interaction site [polypeptide binding]; other site 220668000797 carbohydrate binding site [chemical binding]; other site 220668000798 metal binding site [ion binding]; metal-binding site 220668000799 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668000800 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 220668000801 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 220668000802 FtsX-like permease family; Region: FtsX; pfam02687 220668000803 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 220668000804 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 220668000805 Walker A/P-loop; other site 220668000806 ATP binding site [chemical binding]; other site 220668000807 Q-loop/lid; other site 220668000808 ABC transporter signature motif; other site 220668000809 Walker B; other site 220668000810 D-loop; other site 220668000811 H-loop/switch region; other site 220668000812 CAAX protease self-immunity; Region: Abi; pfam02517 220668000813 CAAX protease self-immunity; Region: Abi; pfam02517 220668000814 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 220668000815 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 220668000816 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 220668000817 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 220668000818 lipoyl attachment site [posttranslational modification]; other site 220668000819 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 220668000820 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 220668000821 DEAD_2; Region: DEAD_2; pfam06733 220668000822 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 220668000823 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 220668000824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668000825 Coenzyme A binding pocket [chemical binding]; other site 220668000826 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668000827 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 220668000828 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 220668000829 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 220668000830 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 220668000831 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 220668000832 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 220668000833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668000834 dimer interface [polypeptide binding]; other site 220668000835 conserved gate region; other site 220668000836 putative PBP binding loops; other site 220668000837 ABC-ATPase subunit interface; other site 220668000838 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 220668000839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668000840 dimer interface [polypeptide binding]; other site 220668000841 conserved gate region; other site 220668000842 putative PBP binding loops; other site 220668000843 ABC-ATPase subunit interface; other site 220668000844 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 220668000845 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 220668000846 Walker A/P-loop; other site 220668000847 ATP binding site [chemical binding]; other site 220668000848 Q-loop/lid; other site 220668000849 ABC transporter signature motif; other site 220668000850 Walker B; other site 220668000851 D-loop; other site 220668000852 H-loop/switch region; other site 220668000853 TOBE domain; Region: TOBE_2; pfam08402 220668000854 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668000855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668000856 non-specific DNA binding site [nucleotide binding]; other site 220668000857 salt bridge; other site 220668000858 sequence-specific DNA binding site [nucleotide binding]; other site 220668000859 Cupin domain; Region: Cupin_2; pfam07883 220668000860 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 220668000861 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 220668000862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668000863 Coenzyme A binding pocket [chemical binding]; other site 220668000864 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 220668000865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668000866 Coenzyme A binding pocket [chemical binding]; other site 220668000867 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 220668000868 Predicted transcriptional regulators [Transcription]; Region: COG1725 220668000869 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668000870 DNA-binding site [nucleotide binding]; DNA binding site 220668000871 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 220668000872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668000873 ATP binding site [chemical binding]; other site 220668000874 Q-loop/lid; other site 220668000875 ABC transporter signature motif; other site 220668000876 Walker B; other site 220668000877 D-loop; other site 220668000878 H-loop/switch region; other site 220668000879 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 220668000880 putative catalytic cysteine [active] 220668000881 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 220668000882 intersubunit interface [polypeptide binding]; other site 220668000883 active site 220668000884 zinc binding site [ion binding]; other site 220668000885 Na+ binding site [ion binding]; other site 220668000886 putative symporter YagG; Provisional; Region: PRK09669; cl15392 220668000887 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 220668000888 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 220668000889 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 220668000890 Peptidase family C69; Region: Peptidase_C69; pfam03577 220668000891 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 220668000892 Biotin operon repressor [Transcription]; Region: BirA; COG1654 220668000893 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 220668000894 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 220668000895 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 220668000896 CHY zinc finger; Region: zf-CHY; cl19861 220668000897 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 220668000898 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 220668000899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668000900 homodimer interface [polypeptide binding]; other site 220668000901 catalytic residue [active] 220668000902 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 220668000903 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 220668000904 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 220668000905 Walker A/P-loop; other site 220668000906 ATP binding site [chemical binding]; other site 220668000907 Q-loop/lid; other site 220668000908 ABC transporter signature motif; other site 220668000909 Walker B; other site 220668000910 D-loop; other site 220668000911 H-loop/switch region; other site 220668000912 type II secretion system protein F; Region: GspF; TIGR02120 220668000913 Predicted transcriptional regulators [Transcription]; Region: COG1695 220668000914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668000915 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668000916 putative substrate translocation pore; other site 220668000917 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 220668000918 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 220668000919 tetramer (dimer of dimers) interface [polypeptide binding]; other site 220668000920 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 220668000921 NAD binding site [chemical binding]; other site 220668000922 dimer interface [polypeptide binding]; other site 220668000923 substrate binding site [chemical binding]; other site 220668000924 ATP-dependent protease Lon; Provisional; Region: PRK13765 220668000925 Zinc-dependent metalloprotease; Region: ZnMc; smart00235 220668000926 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 220668000927 active site 220668000928 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 220668000929 tetramer (dimer of dimers) interface [polypeptide binding]; other site 220668000930 active site 220668000931 dimer interface [polypeptide binding]; other site 220668000932 multicopper oxidase; Provisional; Region: PRK10965 220668000933 Cupredoxin superfamily; Region: Cupredoxin; cl19115 220668000934 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 220668000935 Domain 1 interface [polypeptide binding]; other site 220668000936 Domain 3 interface [polypeptide binding]; other site 220668000937 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 220668000938 Domain 2 interface [polypeptide binding]; other site 220668000939 Domain 1 interface [polypeptide binding]; other site 220668000940 Type 1 (T1) Cu binding site [ion binding]; other site 220668000941 trinuclear Cu binding site [ion binding]; other site 220668000942 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 220668000943 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 220668000944 substrate binding site [chemical binding]; other site 220668000945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668000946 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 220668000947 Walker A motif; other site 220668000948 ATP binding site [chemical binding]; other site 220668000949 Walker B motif; other site 220668000950 Uncharacterized conserved protein [Function unknown]; Region: COG3410 220668000951 Transcriptional regulator; Region: Rrf2; pfam02082 220668000952 Rrf2 family protein; Region: rrf2_super; TIGR00738 220668000953 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 220668000954 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 220668000955 carboxyltransferase (CT) interaction site; other site 220668000956 biotinylation site [posttranslational modification]; other site 220668000957 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 220668000958 active site 220668000959 tetramer interface [polypeptide binding]; other site 220668000960 short chain dehydrogenase; Validated; Region: PRK06182 220668000961 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 220668000962 NADP binding site [chemical binding]; other site 220668000963 active site 220668000964 steroid binding site; other site 220668000965 Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8; Region: RNase_H_like; cl14782 220668000966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668000967 dimer interface [polypeptide binding]; other site 220668000968 conserved gate region; other site 220668000969 putative PBP binding loops; other site 220668000970 ABC-ATPase subunit interface; other site 220668000971 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 220668000972 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 220668000973 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668000974 Walker A/P-loop; other site 220668000975 ATP binding site [chemical binding]; other site 220668000976 Q-loop/lid; other site 220668000977 ABC transporter signature motif; other site 220668000978 Walker B; other site 220668000979 D-loop; other site 220668000980 H-loop/switch region; other site 220668000981 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 220668000982 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668000983 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 220668000984 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 220668000985 glycerol kinase; Provisional; Region: glpK; PRK00047 220668000986 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 220668000987 N- and C-terminal domain interface [polypeptide binding]; other site 220668000988 active site 220668000989 MgATP binding site [chemical binding]; other site 220668000990 catalytic site [active] 220668000991 metal binding site [ion binding]; metal-binding site 220668000992 glycerol binding site [chemical binding]; other site 220668000993 homotetramer interface [polypeptide binding]; other site 220668000994 homodimer interface [polypeptide binding]; other site 220668000995 FBP binding site [chemical binding]; other site 220668000996 protein IIAGlc interface [polypeptide binding]; other site 220668000997 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 220668000998 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668000999 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 220668001000 amphipathic channel; other site 220668001001 Asn-Pro-Ala signature motifs; other site 220668001002 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668001003 Pre-toxin TG; Region: PT-TG; pfam14449 220668001004 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 220668001005 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 220668001006 Putative toxin 53; Region: Toxin_53; pfam15532 220668001007 Immunity protein 38; Region: Imm38; pfam15599 220668001008 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 220668001009 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 220668001010 active site 220668001011 substrate binding site [chemical binding]; other site 220668001012 trimer interface [polypeptide binding]; other site 220668001013 CoA binding site [chemical binding]; other site 220668001014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668001015 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668001016 putative substrate translocation pore; other site 220668001017 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 220668001018 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668001019 active site 220668001020 motif I; other site 220668001021 motif II; other site 220668001022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668001023 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 220668001024 Cupin domain; Region: Cupin_2; cl17218 220668001025 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 220668001026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 220668001027 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668001028 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 220668001029 active site 220668001030 motif I; other site 220668001031 motif II; other site 220668001032 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 220668001033 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 220668001034 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 220668001035 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 220668001036 putative metal binding site; other site 220668001037 CAAX protease self-immunity; Region: Abi; pfam02517 220668001038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 220668001039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 220668001040 ATP binding site [chemical binding]; other site 220668001041 Mg2+ binding site [ion binding]; other site 220668001042 G-X-G motif; other site 220668001043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 220668001044 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 220668001045 active site 220668001046 phosphorylation site [posttranslational modification] 220668001047 intermolecular recognition site; other site 220668001048 dimerization interface [polypeptide binding]; other site 220668001049 LytTr DNA-binding domain; Region: LytTR; pfam04397 220668001050 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 220668001051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 220668001052 active site 220668001053 phosphorylation site [posttranslational modification] 220668001054 intermolecular recognition site; other site 220668001055 dimerization interface [polypeptide binding]; other site 220668001056 LytTr DNA-binding domain; Region: LytTR; pfam04397 220668001057 CAAX protease self-immunity; Region: Abi; pfam02517 220668001058 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 220668001059 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 220668001060 putative active site [active] 220668001061 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 220668001062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668001063 Walker A/P-loop; other site 220668001064 ATP binding site [chemical binding]; other site 220668001065 Q-loop/lid; other site 220668001066 ABC transporter signature motif; other site 220668001067 Walker B; other site 220668001068 D-loop; other site 220668001069 H-loop/switch region; other site 220668001070 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 220668001071 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 220668001072 HlyD family secretion protein; Region: HlyD_3; pfam13437 220668001073 CAAX protease self-immunity; Region: Abi; pfam02517 220668001074 CAAX protease self-immunity; Region: Abi; pfam02517 220668001075 CAAX protease self-immunity; Region: Abi; pfam02517 220668001076 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 220668001077 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668001078 sequence-specific DNA binding site [nucleotide binding]; other site 220668001079 salt bridge; other site 220668001080 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 220668001081 Part of AAA domain; Region: AAA_19; pfam13245 220668001082 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 220668001083 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 220668001084 putative active site [active] 220668001085 catalytic triad [active] 220668001086 putative dimer interface [polypeptide binding]; other site 220668001087 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 220668001088 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 220668001089 active site 220668001090 HIGH motif; other site 220668001091 dimer interface [polypeptide binding]; other site 220668001092 KMSKS motif; other site 220668001093 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 220668001094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668001095 DNA-binding site [nucleotide binding]; DNA binding site 220668001096 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 220668001097 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 220668001098 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 220668001099 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 220668001100 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 220668001101 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 220668001102 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 220668001103 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 220668001104 nucleotide binding site [chemical binding]; other site 220668001105 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 220668001106 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 220668001107 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 220668001108 putative active site [active] 220668001109 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 220668001110 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 220668001111 FMN binding site [chemical binding]; other site 220668001112 active site 220668001113 catalytic residues [active] 220668001114 substrate binding site [chemical binding]; other site 220668001115 exopolyphosphatase; Region: exo_poly_only; TIGR03706 220668001116 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 220668001117 homodimer interface [polypeptide binding]; other site 220668001118 catalytic residues [active] 220668001119 NAD binding site [chemical binding]; other site 220668001120 substrate binding pocket [chemical binding]; other site 220668001121 flexible flap; other site 220668001122 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 220668001123 NAD+ binding site [chemical binding]; other site 220668001124 substrate binding site [chemical binding]; other site 220668001125 putative Zn binding site [ion binding]; other site 220668001126 Protein of unknown function DUF72; Region: DUF72; pfam01904 220668001127 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 220668001128 nudix motif; other site 220668001129 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 220668001130 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 220668001131 active site 220668001132 HIGH motif; other site 220668001133 KMSKS motif; other site 220668001134 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 220668001135 tRNA binding surface [nucleotide binding]; other site 220668001136 anticodon binding site; other site 220668001137 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 220668001138 dimer interface [polypeptide binding]; other site 220668001139 putative tRNA-binding site [nucleotide binding]; other site 220668001140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668001141 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 220668001142 putative substrate translocation pore; other site 220668001143 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 220668001144 active site 220668001145 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 220668001146 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 220668001147 putative active site [active] 220668001148 putative metal binding site [ion binding]; other site 220668001149 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 220668001150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 220668001151 S-adenosylmethionine binding site [chemical binding]; other site 220668001152 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 220668001153 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 220668001154 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 220668001155 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 220668001156 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 220668001157 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 220668001158 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 220668001159 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 220668001160 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 220668001161 ABC-ATPase subunit interface; other site 220668001162 dimer interface [polypeptide binding]; other site 220668001163 putative PBP binding regions; other site 220668001164 pur operon repressor; Provisional; Region: PRK09213 220668001165 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 220668001166 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 220668001167 active site 220668001168 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 220668001169 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 220668001170 Substrate binding site; other site 220668001171 Mg++ binding site; other site 220668001172 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 220668001173 active site 220668001174 substrate binding site [chemical binding]; other site 220668001175 CoA binding site [chemical binding]; other site 220668001176 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 220668001177 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 220668001178 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 220668001179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 220668001180 active site 220668001181 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 220668001182 putative active site [active] 220668001183 sugar phosphate phosphatase; Provisional; Region: PRK10513 220668001184 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 220668001185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668001186 active site 220668001187 motif I; other site 220668001188 motif II; other site 220668001189 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 220668001190 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 220668001191 Zn2+ binding site [ion binding]; other site 220668001192 Mg2+ binding site [ion binding]; other site 220668001193 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 220668001194 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 220668001195 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 220668001196 CTP synthetase; Validated; Region: pyrG; PRK05380 220668001197 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 220668001198 Catalytic site [active] 220668001199 active site 220668001200 UTP binding site [chemical binding]; other site 220668001201 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 220668001202 active site 220668001203 putative oxyanion hole; other site 220668001204 catalytic triad [active] 220668001205 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668001206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668001207 non-specific DNA binding site [nucleotide binding]; other site 220668001208 salt bridge; other site 220668001209 sequence-specific DNA binding site [nucleotide binding]; other site 220668001210 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 220668001211 Lysine biosynthesis protein LysW; Region: LysW; cl11748 220668001212 Zn binding site [ion binding]; other site 220668001213 ArgX binding interface [polypeptide binding]; other site 220668001214 AAA attachment site [active] 220668001215 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 220668001216 ATP-grasp domain; Region: ATP-grasp_4; cl17255 220668001217 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 220668001218 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 220668001219 inhibitor-cofactor binding pocket; inhibition site 220668001220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668001221 catalytic residue [active] 220668001222 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 220668001223 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 220668001224 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 220668001225 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 220668001226 nucleotide binding site [chemical binding]; other site 220668001227 substrate binding site [chemical binding]; other site 220668001228 M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653 220668001229 N-acetyl-ornithine/N-acetyl-lysine deacetylase; Region: dapE-lys-deAc; TIGR01902 220668001230 metal binding site [ion binding]; metal-binding site 220668001231 putative dimer interface [polypeptide binding]; other site 220668001232 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 220668001233 TPP-binding site [chemical binding]; other site 220668001234 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 220668001235 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 220668001236 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 220668001237 PYR/PP interface [polypeptide binding]; other site 220668001238 dimer interface [polypeptide binding]; other site 220668001239 TPP binding site [chemical binding]; other site 220668001240 H+ Antiporter protein; Region: 2A0121; TIGR00900 220668001241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668001242 putative substrate translocation pore; other site 220668001243 hypothetical protein; Provisional; Region: PRK07206 220668001244 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 220668001245 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 220668001246 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 220668001247 DNA binding residues [nucleotide binding] 220668001248 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 220668001249 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 220668001250 intersubunit interface [polypeptide binding]; other site 220668001251 active site 220668001252 catalytic residue [active] 220668001253 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 220668001254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668001255 putative substrate translocation pore; other site 220668001256 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 220668001257 active site 220668001258 catalytic residues [active] 220668001259 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 220668001260 substrate binding site [chemical binding]; other site 220668001261 dimer interface [polypeptide binding]; other site 220668001262 ATP binding site [chemical binding]; other site 220668001263 seryl-tRNA synthetase; Provisional; Region: PRK05431 220668001264 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 220668001265 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 220668001266 dimer interface [polypeptide binding]; other site 220668001267 active site 220668001268 motif 1; other site 220668001269 motif 2; other site 220668001270 motif 3; other site 220668001271 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 220668001272 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 220668001273 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 220668001274 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 220668001275 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 220668001276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 220668001277 YheO-like PAS domain; Region: PAS_6; pfam08348 220668001278 HTH domain; Region: HTH_22; pfam13309 220668001279 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 220668001280 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 220668001281 hinge; other site 220668001282 active site 220668001283 transcription termination factor Rho; Provisional; Region: rho; PRK09376 220668001284 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 220668001285 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 220668001286 RNA binding site [nucleotide binding]; other site 220668001287 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 220668001288 Walker A motif; other site 220668001289 ATP binding site [chemical binding]; other site 220668001290 Walker B motif; other site 220668001291 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 220668001292 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 220668001293 active site 220668001294 catalytic site [active] 220668001295 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 220668001296 heat shock protein HtpX; Provisional; Region: PRK04897 220668001297 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 220668001298 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 220668001299 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 220668001300 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 220668001301 DEAD-like helicases superfamily; Region: DEXDc; smart00487 220668001302 ATP binding site [chemical binding]; other site 220668001303 Mg++ binding site [ion binding]; other site 220668001304 motif III; other site 220668001305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 220668001306 nucleotide binding region [chemical binding]; other site 220668001307 ATP-binding site [chemical binding]; other site 220668001308 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 220668001309 alanine racemase; Reviewed; Region: alr; PRK00053 220668001310 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 220668001311 active site 220668001312 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 220668001313 dimer interface [polypeptide binding]; other site 220668001314 substrate binding site [chemical binding]; other site 220668001315 catalytic residues [active] 220668001316 PemK-like protein; Region: PemK; pfam02452 220668001317 K+ potassium transporter; Region: K_trans; cl15781 220668001318 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 220668001319 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 220668001320 ATP-grasp domain; Region: ATP-grasp_4; cl17255 220668001321 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 220668001322 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 220668001323 ATP-grasp domain; Region: ATP-grasp_4; cl17255 220668001324 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 220668001325 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 220668001326 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 220668001327 catalytic site [active] 220668001328 subunit interface [polypeptide binding]; other site 220668001329 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 220668001330 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 220668001331 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 220668001332 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 220668001333 heterotetramer interface [polypeptide binding]; other site 220668001334 active site pocket [active] 220668001335 cleavage site 220668001336 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 220668001337 nucleotide binding site [chemical binding]; other site 220668001338 N-acetyl-L-glutamate binding site [chemical binding]; other site 220668001339 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 220668001340 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 220668001341 inhibitor-cofactor binding pocket; inhibition site 220668001342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668001343 catalytic residue [active] 220668001344 ornithine carbamoyltransferase; Validated; Region: PRK02102 220668001345 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 220668001346 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 220668001347 QueT transporter; Region: QueT; pfam06177 220668001348 FOG: CBS domain [General function prediction only]; Region: COG0517 220668001349 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 220668001350 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 220668001351 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 220668001352 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 220668001353 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 220668001354 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 220668001355 tetramer (dimer of dimers) interface [polypeptide binding]; other site 220668001356 NAD binding site [chemical binding]; other site 220668001357 dimer interface [polypeptide binding]; other site 220668001358 substrate binding site [chemical binding]; other site 220668001359 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 220668001360 putative active site [active] 220668001361 catalytic residue [active] 220668001362 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 220668001363 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 220668001364 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 220668001365 ATP binding site [chemical binding]; other site 220668001366 putative Mg++ binding site [ion binding]; other site 220668001367 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 220668001368 nucleotide binding region [chemical binding]; other site 220668001369 ATP-binding site [chemical binding]; other site 220668001370 TRCF domain; Region: TRCF; pfam03461 220668001371 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 220668001372 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 220668001373 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667 220668001374 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 220668001375 RNA binding surface [nucleotide binding]; other site 220668001376 Septum formation initiator; Region: DivIC; pfam04977 220668001377 hypothetical protein; Provisional; Region: PRK08582 220668001378 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 220668001379 RNA binding site [nucleotide binding]; other site 220668001380 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 220668001381 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 220668001382 Ligand Binding Site [chemical binding]; other site 220668001383 TilS substrate C-terminal domain; Region: TilS_C; smart00977 220668001384 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 220668001385 active site 220668001386 FtsH Extracellular; Region: FtsH_ext; pfam06480 220668001387 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 220668001388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668001389 Walker A motif; other site 220668001390 ATP binding site [chemical binding]; other site 220668001391 Walker B motif; other site 220668001392 arginine finger; other site 220668001393 Peptidase family M41; Region: Peptidase_M41; pfam01434 220668001394 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 220668001395 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 220668001396 dimerization interface [polypeptide binding]; other site 220668001397 domain crossover interface; other site 220668001398 redox-dependent activation switch; other site 220668001399 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 220668001400 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 220668001401 FMN binding site [chemical binding]; other site 220668001402 active site 220668001403 catalytic residues [active] 220668001404 substrate binding site [chemical binding]; other site 220668001405 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 220668001406 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 220668001407 dimer interface [polypeptide binding]; other site 220668001408 putative anticodon binding site; other site 220668001409 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 220668001410 motif 1; other site 220668001411 active site 220668001412 motif 2; other site 220668001413 motif 3; other site 220668001414 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 220668001415 POT family; Region: PTR2; cl17359 220668001416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668001417 putative substrate translocation pore; other site 220668001418 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 220668001419 putative phosphoesterase; Region: acc_ester; TIGR03729 220668001420 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 220668001421 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 220668001422 Cupin domain; Region: Cupin_2; cl17218 220668001423 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 220668001424 active site 220668001425 metal binding site [ion binding]; metal-binding site 220668001426 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 220668001427 transmembrane helices; other site 220668001428 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 220668001429 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 220668001430 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 220668001431 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 220668001432 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 220668001433 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 220668001434 active site 220668001435 dimer interface [polypeptide binding]; other site 220668001436 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 220668001437 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668001438 DNA-binding site [nucleotide binding]; DNA binding site 220668001439 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 220668001440 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 220668001441 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 220668001442 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 220668001443 active site 220668001444 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 220668001445 homodimer interface [polypeptide binding]; other site 220668001446 NAD binding pocket [chemical binding]; other site 220668001447 ATP binding pocket [chemical binding]; other site 220668001448 Mg binding site [ion binding]; other site 220668001449 active-site loop [active] 220668001450 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 220668001451 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 220668001452 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 220668001453 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 220668001454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668001455 motif II; other site 220668001456 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 220668001457 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 220668001458 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 220668001459 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 220668001460 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 220668001461 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 220668001462 RNA binding site [nucleotide binding]; other site 220668001463 hypothetical protein; Provisional; Region: PRK04351 220668001464 homoserine dehydrogenase; Provisional; Region: PRK06349 220668001465 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 220668001466 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 220668001467 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 220668001468 homoserine kinase; Provisional; Region: PRK01212 220668001469 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 220668001470 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 220668001471 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 220668001472 putative active site [active] 220668001473 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 220668001474 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 220668001475 active pocket/dimerization site; other site 220668001476 active site 220668001477 phosphorylation site [posttranslational modification] 220668001478 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 220668001479 active site 220668001480 phosphorylation site [posttranslational modification] 220668001481 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 220668001482 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 220668001483 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 220668001484 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 220668001485 acyl-activating enzyme (AAE) consensus motif; other site 220668001486 AMP binding site [chemical binding]; other site 220668001487 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 220668001488 Condensation domain; Region: Condensation; cl19241 220668001489 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 220668001490 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 220668001491 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 220668001492 acyl-activating enzyme (AAE) consensus motif; other site 220668001493 AMP binding site [chemical binding]; other site 220668001494 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 220668001495 peptide synthase; Provisional; Region: PRK12467 220668001496 Condensation domain; Region: Condensation; pfam00668 220668001497 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 220668001498 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 220668001499 acyl-activating enzyme (AAE) consensus motif; other site 220668001500 AMP binding site [chemical binding]; other site 220668001501 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 220668001502 Condensation domain; Region: Condensation; pfam00668 220668001503 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 220668001504 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 220668001505 acyl-activating enzyme (AAE) consensus motif; other site 220668001506 AMP binding site [chemical binding]; other site 220668001507 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 220668001508 Condensation domain; Region: Condensation; cl19241 220668001509 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 220668001510 Condensation domain; Region: Condensation; cl19241 220668001511 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 220668001512 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 220668001513 acyl-activating enzyme (AAE) consensus motif; other site 220668001514 AMP binding site [chemical binding]; other site 220668001515 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 220668001516 Condensation domain; Region: Condensation; cl19241 220668001517 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 220668001518 tetramerization interface [polypeptide binding]; other site 220668001519 active site 220668001520 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 220668001521 Zn2+ binding site [ion binding]; other site 220668001522 Mg2+ binding site [ion binding]; other site 220668001523 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 220668001524 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 220668001525 acyl-activating enzyme (AAE) consensus motif; other site 220668001526 AMP binding site [chemical binding]; other site 220668001527 active site 220668001528 CoA binding site [chemical binding]; other site 220668001529 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 220668001530 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 220668001531 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668001532 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 220668001533 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 220668001534 Domain of unknown function (DUF956); Region: DUF956; pfam06115 220668001535 H+ Antiporter protein; Region: 2A0121; TIGR00900 220668001536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668001537 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 220668001538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668001539 Walker A motif; other site 220668001540 ATP binding site [chemical binding]; other site 220668001541 Walker B motif; other site 220668001542 arginine finger; other site 220668001543 Transcriptional antiterminator [Transcription]; Region: COG3933 220668001544 PRD domain; Region: PRD; pfam00874 220668001545 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 220668001546 active pocket/dimerization site; other site 220668001547 active site 220668001548 phosphorylation site [posttranslational modification] 220668001549 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 220668001550 active site 220668001551 P-loop; other site 220668001552 phosphorylation site [posttranslational modification] 220668001553 PRD domain; Region: PRD; pfam00874 220668001554 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 220668001555 active pocket/dimerization site; other site 220668001556 active site 220668001557 phosphorylation site [posttranslational modification] 220668001558 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 220668001559 active site 220668001560 phosphorylation site [posttranslational modification] 220668001561 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 220668001562 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 220668001563 dimer interface [polypeptide binding]; other site 220668001564 active site 220668001565 CoA binding pocket [chemical binding]; other site 220668001566 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 220668001567 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 220668001568 carboxyltransferase (CT) interaction site; other site 220668001569 biotinylation site [posttranslational modification]; other site 220668001570 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 220668001571 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 220668001572 ATP-grasp domain; Region: ATP-grasp_4; cl17255 220668001573 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 220668001574 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 220668001575 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 220668001576 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 220668001577 Membrane transport protein; Region: Mem_trans; pfam03547 220668001578 EamA-like transporter family; Region: EamA; pfam00892 220668001579 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 220668001580 EamA-like transporter family; Region: EamA; pfam00892 220668001581 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 220668001582 catalytic core [active] 220668001583 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 220668001584 active site 220668001585 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 220668001586 trimer interface [polypeptide binding]; other site 220668001587 active site 220668001588 G bulge; other site 220668001589 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 220668001590 tetramer (dimer of dimers) interface [polypeptide binding]; other site 220668001591 active site 220668001592 dimer interface [polypeptide binding]; other site 220668001593 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668001594 Coenzyme A binding pocket [chemical binding]; other site 220668001595 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 220668001596 trimer interface [polypeptide binding]; other site 220668001597 active site 220668001598 DNA repair protein RadA; Provisional; Region: PRK11823 220668001599 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 220668001600 Walker A motif/ATP binding site; other site 220668001601 ATP binding site [chemical binding]; other site 220668001602 Walker B motif; other site 220668001603 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 220668001604 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 220668001605 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 220668001606 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 220668001607 putative active site [active] 220668001608 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 220668001609 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 220668001610 active site 220668001611 HIGH motif; other site 220668001612 KMSKS motif; other site 220668001613 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 220668001614 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 220668001615 active site 220668001616 HIGH motif; other site 220668001617 KMSKS motif; other site 220668001618 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 220668001619 tRNA binding surface [nucleotide binding]; other site 220668001620 anticodon binding site; other site 220668001621 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 220668001622 active site 220668001623 metal binding site [ion binding]; metal-binding site 220668001624 dimerization interface [polypeptide binding]; other site 220668001625 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 220668001626 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 220668001627 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 220668001628 YacP-like NYN domain; Region: NYN_YacP; pfam05991 220668001629 RNA polymerase factor sigma-70; Validated; Region: PRK08295 220668001630 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 220668001631 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 220668001632 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 220668001633 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 220668001634 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 220668001635 putative homodimer interface [polypeptide binding]; other site 220668001636 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 220668001637 heterodimer interface [polypeptide binding]; other site 220668001638 homodimer interface [polypeptide binding]; other site 220668001639 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668001640 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 220668001641 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 220668001642 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 220668001643 23S rRNA interface [nucleotide binding]; other site 220668001644 L7/L12 interface [polypeptide binding]; other site 220668001645 putative thiostrepton binding site; other site 220668001646 L25 interface [polypeptide binding]; other site 220668001647 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 220668001648 mRNA/rRNA interface [nucleotide binding]; other site 220668001649 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 220668001650 23S rRNA interface [nucleotide binding]; other site 220668001651 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 220668001652 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 220668001653 peripheral dimer interface [polypeptide binding]; other site 220668001654 core dimer interface [polypeptide binding]; other site 220668001655 L10 interface [polypeptide binding]; other site 220668001656 L11 interface [polypeptide binding]; other site 220668001657 putative EF-Tu interaction site [polypeptide binding]; other site 220668001658 putative EF-G interaction site [polypeptide binding]; other site 220668001659 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 220668001660 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 220668001661 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 220668001662 active site 220668001663 catalytic residues [active] 220668001664 DNA binding site [nucleotide binding] 220668001665 Int/Topo IB signature motif; other site 220668001666 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 220668001667 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 220668001668 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 220668001669 Domain of unknown function (DUF955); Region: DUF955; pfam06114 220668001670 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668001671 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668001672 non-specific DNA binding site [nucleotide binding]; other site 220668001673 salt bridge; other site 220668001674 sequence-specific DNA binding site [nucleotide binding]; other site 220668001675 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668001676 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668001677 non-specific DNA binding site [nucleotide binding]; other site 220668001678 salt bridge; other site 220668001679 sequence-specific DNA binding site [nucleotide binding]; other site 220668001680 proteasome ATPase; Region: pup_AAA; TIGR03689 220668001681 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668001682 non-specific DNA binding site [nucleotide binding]; other site 220668001683 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668001684 salt bridge; other site 220668001685 sequence-specific DNA binding site [nucleotide binding]; other site 220668001686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668001687 non-specific DNA binding site [nucleotide binding]; other site 220668001688 salt bridge; other site 220668001689 sequence-specific DNA binding site [nucleotide binding]; other site 220668001690 Helix-turn-helix domain; Region: HTH_17; pfam12728 220668001691 RecT family; Region: RecT; pfam03837 220668001692 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 220668001693 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 220668001694 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 220668001695 Endodeoxyribonuclease RusA; Region: RusA; cl01885 220668001696 YopX protein; Region: YopX; pfam09643 220668001697 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 220668001698 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 220668001699 Terminase small subunit; Region: Terminase_2; cl01513 220668001700 Phage terminase large subunit; Region: Terminase_3; cl12054 220668001701 Terminase-like family; Region: Terminase_6; pfam03237 220668001702 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 220668001703 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 220668001704 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 220668001705 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 220668001706 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 220668001707 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; cl12124 220668001708 Phage protein; Region: DUF3647; pfam12363 220668001709 phiKZ-like phage internal head proteins; Region: phiKZ_IP; pfam12699 220668001710 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 220668001711 tape measure domain; Region: tape_meas_nterm; TIGR02675 220668001712 membrane protein P6; Region: PHA01399 220668001713 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 220668001714 catalytic residue [active] 220668001715 Phage tail protein; Region: Sipho_tail; cl17486 220668001716 Prophage endopeptidase tail; Region: Prophage_tail; cl19379 220668001717 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 220668001718 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 220668001719 active site 220668001720 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 220668001721 active site 220668001722 catalytic triad [active] 220668001723 oxyanion hole [active] 220668001724 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 220668001725 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 220668001726 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 220668001727 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 220668001728 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 220668001729 active site 220668001730 Bacterial SH3 domain; Region: SH3_5; pfam08460 220668001731 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 220668001732 Bacteriophage holin; Region: Phage_holin_1; cl02344 220668001733 cell division control protein 6; Reviewed; Region: cdc6; PRK00411 220668001734 Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250 220668001735 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 220668001736 Predicted integral membrane protein [Function unknown]; Region: COG0392 220668001737 Uncharacterized conserved protein [Function unknown]; Region: COG2898 220668001738 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 220668001739 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 220668001740 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 220668001741 dimer interface [polypeptide binding]; other site 220668001742 putative radical transfer pathway; other site 220668001743 diiron center [ion binding]; other site 220668001744 tyrosyl radical; other site 220668001745 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 220668001746 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 220668001747 Class I ribonucleotide reductase; Region: RNR_I; cd01679 220668001748 active site 220668001749 dimer interface [polypeptide binding]; other site 220668001750 catalytic residues [active] 220668001751 effector binding site; other site 220668001752 R2 peptide binding site; other site 220668001753 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 220668001754 catalytic residues [active] 220668001755 Methyltransferase domain; Region: Methyltransf_31; pfam13847 220668001756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 220668001757 S-adenosylmethionine binding site [chemical binding]; other site 220668001758 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 220668001759 nucleoside/Zn binding site; other site 220668001760 dimer interface [polypeptide binding]; other site 220668001761 catalytic motif [active] 220668001762 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 220668001763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668001764 Walker A motif; other site 220668001765 ATP binding site [chemical binding]; other site 220668001766 DNA polymerase III subunit delta'; Validated; Region: PRK08485 220668001767 Walker B motif; other site 220668001768 arginine finger; other site 220668001769 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 220668001770 hypothetical protein; Validated; Region: PRK00153 220668001771 recombination protein RecR; Reviewed; Region: recR; PRK00076 220668001772 RecR protein; Region: RecR; pfam02132 220668001773 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 220668001774 putative active site [active] 220668001775 putative metal-binding site [ion binding]; other site 220668001776 tetramer interface [polypeptide binding]; other site 220668001777 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 220668001778 thymidylate kinase; Validated; Region: tmk; PRK00698 220668001779 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 220668001780 TMP-binding site; other site 220668001781 ATP-binding site [chemical binding]; other site 220668001782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 220668001783 DNA polymerase III subunit delta'; Validated; Region: PRK08058 220668001784 DNA polymerase III subunit delta'; Validated; Region: PRK08485 220668001785 Protein of unknown function (DUF972); Region: DUF972; pfam06156 220668001786 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 220668001787 putative SAM binding site [chemical binding]; other site 220668001788 putative homodimer interface [polypeptide binding]; other site 220668001789 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 220668001790 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 220668001791 active site 220668001792 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 220668001793 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 220668001794 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 220668001795 NAD binding site [chemical binding]; other site 220668001796 homodimer interface [polypeptide binding]; other site 220668001797 active site 220668001798 substrate binding site [chemical binding]; other site 220668001799 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 220668001800 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 220668001801 catalytic residue [active] 220668001802 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 220668001803 phosphonoacetaldehyde hydrolase; Region: phosphonatase; TIGR01422 220668001804 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 220668001805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668001806 dimer interface [polypeptide binding]; other site 220668001807 conserved gate region; other site 220668001808 ABC-ATPase subunit interface; other site 220668001809 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 220668001810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668001811 dimer interface [polypeptide binding]; other site 220668001812 conserved gate region; other site 220668001813 putative PBP binding loops; other site 220668001814 ABC-ATPase subunit interface; other site 220668001815 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 220668001816 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 220668001817 Walker A/P-loop; other site 220668001818 ATP binding site [chemical binding]; other site 220668001819 Q-loop/lid; other site 220668001820 ABC transporter signature motif; other site 220668001821 Walker B; other site 220668001822 D-loop; other site 220668001823 H-loop/switch region; other site 220668001824 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 220668001825 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 220668001826 Glycoprotease family; Region: Peptidase_M22; pfam00814 220668001827 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 220668001828 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 220668001829 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668001830 Coenzyme A binding pocket [chemical binding]; other site 220668001831 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 220668001832 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668001833 Coenzyme A binding pocket [chemical binding]; other site 220668001834 UGMP family protein; Validated; Region: PRK09604 220668001835 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 220668001836 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 220668001837 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 220668001838 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 220668001839 ABC transporter; Region: ABC_tran_2; pfam12848 220668001840 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 220668001841 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 220668001842 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 220668001843 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 220668001844 CoA binding domain; Region: CoA_binding; pfam02629 220668001845 CAAX protease self-immunity; Region: Abi; pfam02517 220668001846 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 220668001847 oligomerisation interface [polypeptide binding]; other site 220668001848 mobile loop; other site 220668001849 roof hairpin; other site 220668001850 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 220668001851 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 220668001852 ring oligomerisation interface [polypeptide binding]; other site 220668001853 ATP/Mg binding site [chemical binding]; other site 220668001854 stacking interactions; other site 220668001855 hinge regions; other site 220668001856 Amino acid permease; Region: AA_permease_2; pfam13520 220668001857 K+ potassium transporter; Region: K_trans; cl15781 220668001858 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 220668001859 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 220668001860 Mg++ binding site [ion binding]; other site 220668001861 putative catalytic motif [active] 220668001862 substrate binding site [chemical binding]; other site 220668001863 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 220668001864 Uncharacterized conserved protein [Function unknown]; Region: COG1739 220668001865 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 220668001866 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 220668001867 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 220668001868 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 220668001869 ATP binding site [chemical binding]; other site 220668001870 putative Mg++ binding site [ion binding]; other site 220668001871 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 220668001872 ATP-binding site [chemical binding]; other site 220668001873 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 220668001874 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 220668001875 active site 220668001876 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 220668001877 30S subunit binding site; other site 220668001878 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 220668001879 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 220668001880 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 220668001881 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 220668001882 nucleotide binding region [chemical binding]; other site 220668001883 ATP-binding site [chemical binding]; other site 220668001884 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 220668001885 peptide chain release factor 2; Validated; Region: prfB; PRK00578 220668001886 This domain is found in peptide chain release factors; Region: PCRF; smart00937 220668001887 RF-1 domain; Region: RF-1; pfam00472 220668001888 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 220668001889 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 220668001890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 220668001891 active site 220668001892 phosphorylation site [posttranslational modification] 220668001893 intermolecular recognition site; other site 220668001894 dimerization interface [polypeptide binding]; other site 220668001895 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 220668001896 DNA binding site [nucleotide binding] 220668001897 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 220668001898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 220668001899 dimer interface [polypeptide binding]; other site 220668001900 phosphorylation site [posttranslational modification] 220668001901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 220668001902 ATP binding site [chemical binding]; other site 220668001903 Mg2+ binding site [ion binding]; other site 220668001904 G-X-G motif; other site 220668001905 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 220668001906 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 220668001907 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 220668001908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668001909 dimer interface [polypeptide binding]; other site 220668001910 conserved gate region; other site 220668001911 putative PBP binding loops; other site 220668001912 ABC-ATPase subunit interface; other site 220668001913 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 220668001914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668001915 dimer interface [polypeptide binding]; other site 220668001916 conserved gate region; other site 220668001917 putative PBP binding loops; other site 220668001918 ABC-ATPase subunit interface; other site 220668001919 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 220668001920 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 220668001921 Walker A/P-loop; other site 220668001922 ATP binding site [chemical binding]; other site 220668001923 Q-loop/lid; other site 220668001924 ABC transporter signature motif; other site 220668001925 Walker B; other site 220668001926 D-loop; other site 220668001927 H-loop/switch region; other site 220668001928 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 220668001929 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 220668001930 Walker A/P-loop; other site 220668001931 ATP binding site [chemical binding]; other site 220668001932 Q-loop/lid; other site 220668001933 ABC transporter signature motif; other site 220668001934 Walker B; other site 220668001935 D-loop; other site 220668001936 H-loop/switch region; other site 220668001937 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 220668001938 PhoU domain; Region: PhoU; pfam01895 220668001939 PhoU domain; Region: PhoU; pfam01895 220668001940 PspC domain; Region: PspC; pfam04024 220668001941 Membrane protein of unknown function; Region: DUF360; cl00850 220668001942 HPr kinase/phosphorylase; Provisional; Region: PRK05428 220668001943 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 220668001944 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 220668001945 Hpr binding site; other site 220668001946 active site 220668001947 homohexamer subunit interaction site [polypeptide binding]; other site 220668001948 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 220668001949 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 220668001950 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 220668001951 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 220668001952 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 220668001953 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 220668001954 active site 220668001955 tetramer interface; other site 220668001956 EAL domain; Region: EAL; pfam00563 220668001957 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 220668001958 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 220668001959 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 220668001960 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 220668001961 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668001962 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 220668001963 Predicted membrane protein [Function unknown]; Region: COG2323 220668001964 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 220668001965 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 220668001966 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 220668001967 active site 220668001968 substrate binding site [chemical binding]; other site 220668001969 metal binding site [ion binding]; metal-binding site 220668001970 EAL domain; Region: EAL; pfam00563 220668001971 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 220668001972 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668001973 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 220668001974 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 220668001975 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 220668001976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668001977 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668001978 putative substrate translocation pore; other site 220668001979 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 220668001980 Zn2+ binding site [ion binding]; other site 220668001981 Mg2+ binding site [ion binding]; other site 220668001982 excinuclease ABC subunit B; Provisional; Region: PRK05298 220668001983 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 220668001984 ATP binding site [chemical binding]; other site 220668001985 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 220668001986 nucleotide binding region [chemical binding]; other site 220668001987 ATP-binding site [chemical binding]; other site 220668001988 Ultra-violet resistance protein B; Region: UvrB; pfam12344 220668001989 UvrB/uvrC motif; Region: UVR; pfam02151 220668001990 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 220668001991 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 220668001992 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 220668001993 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 220668001994 S-ribosylhomocysteinase; Provisional; Region: PRK02260 220668001995 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 220668001996 ANP binding site [chemical binding]; other site 220668001997 Substrate Binding Site II [chemical binding]; other site 220668001998 Substrate Binding Site I [chemical binding]; other site 220668001999 argininosuccinate lyase; Provisional; Region: PRK00855 220668002000 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 220668002001 active sites [active] 220668002002 tetramer interface [polypeptide binding]; other site 220668002003 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 220668002004 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 220668002005 AAA domain; Region: AAA_33; pfam13671 220668002006 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 220668002007 phosphate binding site [ion binding]; other site 220668002008 putative substrate binding pocket [chemical binding]; other site 220668002009 dimer interface [polypeptide binding]; other site 220668002010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 220668002011 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 220668002012 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 220668002013 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 220668002014 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 220668002015 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 220668002016 peptide binding site [polypeptide binding]; other site 220668002017 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 220668002018 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 220668002019 putative ligand binding site [chemical binding]; other site 220668002020 putative NAD binding site [chemical binding]; other site 220668002021 catalytic site [active] 220668002022 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 220668002023 oligomer interface [polypeptide binding]; other site 220668002024 active site residues [active] 220668002025 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 220668002026 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 220668002027 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 220668002028 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 220668002029 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 220668002030 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 220668002031 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 220668002032 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 220668002033 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 220668002034 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 220668002035 substrate binding site [chemical binding]; other site 220668002036 hinge regions; other site 220668002037 ADP binding site [chemical binding]; other site 220668002038 catalytic site [active] 220668002039 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 220668002040 substrate binding site [chemical binding]; other site 220668002041 dimer interface [polypeptide binding]; other site 220668002042 catalytic triad [active] 220668002043 enolase; Provisional; Region: eno; PRK00077 220668002044 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 220668002045 dimer interface [polypeptide binding]; other site 220668002046 metal binding site [ion binding]; metal-binding site 220668002047 substrate binding pocket [chemical binding]; other site 220668002048 Phosphotransferase enzyme family; Region: APH; pfam01636 220668002049 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 220668002050 Cl- selectivity filter; other site 220668002051 Cl- binding residues [ion binding]; other site 220668002052 pore gating glutamate residue; other site 220668002053 dimer interface [polypeptide binding]; other site 220668002054 H+/Cl- coupling transport residue; other site 220668002055 TrkA-C domain; Region: TrkA_C; pfam02080 220668002056 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 220668002057 Esterase/lipase [General function prediction only]; Region: COG1647 220668002058 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cl00230 220668002059 ribonuclease R; Region: RNase_R; TIGR02063 220668002060 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 220668002061 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 220668002062 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 220668002063 RNA binding site [nucleotide binding]; other site 220668002064 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 220668002065 SmpB-tmRNA interface; other site 220668002066 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 220668002067 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 220668002068 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 220668002069 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 220668002070 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 220668002071 substrate binding pocket [chemical binding]; other site 220668002072 membrane-bound complex binding site; other site 220668002073 hinge residues; other site 220668002074 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 220668002075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668002076 dimer interface [polypeptide binding]; other site 220668002077 conserved gate region; other site 220668002078 putative PBP binding loops; other site 220668002079 ABC-ATPase subunit interface; other site 220668002080 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 220668002081 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 220668002082 Walker A/P-loop; other site 220668002083 ATP binding site [chemical binding]; other site 220668002084 Q-loop/lid; other site 220668002085 ABC transporter signature motif; other site 220668002086 Walker B; other site 220668002087 D-loop; other site 220668002088 H-loop/switch region; other site 220668002089 Tubby C 2; Region: Tub_2; cl02043 220668002090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668002091 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 220668002092 active site 220668002093 motif I; other site 220668002094 motif II; other site 220668002095 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 220668002096 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 220668002097 ligand binding site [chemical binding]; other site 220668002098 active site 220668002099 UGI interface [polypeptide binding]; other site 220668002100 catalytic site [active] 220668002101 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 220668002102 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 220668002103 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 220668002104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668002105 Coenzyme A binding pocket [chemical binding]; other site 220668002106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 220668002107 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 220668002108 active site 220668002109 catalytic site [active] 220668002110 substrate binding site [chemical binding]; other site 220668002111 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 220668002112 active site 220668002113 putative catalytic site [active] 220668002114 DNA binding site [nucleotide binding] 220668002115 putative phosphate binding site [ion binding]; other site 220668002116 metal binding site A [ion binding]; metal-binding site 220668002117 AP binding site [nucleotide binding]; other site 220668002118 metal binding site B [ion binding]; metal-binding site 220668002119 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 220668002120 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 220668002121 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 220668002122 FAD binding domain; Region: FAD_binding_4; pfam01565 220668002123 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 220668002124 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 220668002125 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 220668002126 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668002127 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 220668002128 dimerization interface [polypeptide binding]; other site 220668002129 putative Zn2+ binding site [ion binding]; other site 220668002130 putative DNA binding site [nucleotide binding]; other site 220668002131 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 220668002132 Uncharacterized conserved protein [Function unknown]; Region: COG1624 220668002133 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 220668002134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 220668002135 YbbR-like protein; Region: YbbR; pfam07949 220668002136 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 220668002137 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 220668002138 active site 220668002139 substrate binding site [chemical binding]; other site 220668002140 metal binding site [ion binding]; metal-binding site 220668002141 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 220668002142 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 220668002143 glutaminase active site [active] 220668002144 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 220668002145 dimer interface [polypeptide binding]; other site 220668002146 active site 220668002147 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 220668002148 dimer interface [polypeptide binding]; other site 220668002149 active site 220668002150 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 220668002151 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 220668002152 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668002153 active site 220668002154 motif I; other site 220668002155 motif II; other site 220668002156 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 220668002157 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668002158 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 220668002159 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 220668002160 active site 220668002161 catalytic residues [active] 220668002162 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 220668002163 dimer interface [polypeptide binding]; other site 220668002164 FMN binding site [chemical binding]; other site 220668002165 NADPH bind site [chemical binding]; other site 220668002166 glycerol kinase; Provisional; Region: glpK; PRK00047 220668002167 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 220668002168 N- and C-terminal domain interface [polypeptide binding]; other site 220668002169 active site 220668002170 MgATP binding site [chemical binding]; other site 220668002171 catalytic site [active] 220668002172 metal binding site [ion binding]; metal-binding site 220668002173 glycerol binding site [chemical binding]; other site 220668002174 homotetramer interface [polypeptide binding]; other site 220668002175 homodimer interface [polypeptide binding]; other site 220668002176 FBP binding site [chemical binding]; other site 220668002177 protein IIAGlc interface [polypeptide binding]; other site 220668002178 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 220668002179 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 220668002180 putative catalytic residues [active] 220668002181 VanZ like family; Region: VanZ; cl01971 220668002182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668002183 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668002184 putative substrate translocation pore; other site 220668002185 exopolyphosphatase; Region: exo_poly_only; TIGR03706 220668002186 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 220668002187 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 220668002188 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 220668002189 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 220668002190 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 220668002191 putative domain interface [polypeptide binding]; other site 220668002192 putative active site [active] 220668002193 catalytic site [active] 220668002194 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 220668002195 putative domain interface [polypeptide binding]; other site 220668002196 putative active site [active] 220668002197 catalytic site [active] 220668002198 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 220668002199 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 220668002200 Zn2+ binding site [ion binding]; other site 220668002201 Mg2+ binding site [ion binding]; other site 220668002202 LicD family; Region: LicD; pfam04991 220668002203 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668002204 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 220668002205 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 220668002206 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 220668002207 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 220668002208 PYR/PP interface [polypeptide binding]; other site 220668002209 dimer interface [polypeptide binding]; other site 220668002210 tetramer interface [polypeptide binding]; other site 220668002211 TPP binding site [chemical binding]; other site 220668002212 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 220668002213 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 220668002214 TPP-binding site [chemical binding]; other site 220668002215 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 220668002216 active site 220668002217 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 220668002218 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 220668002219 PYR/PP interface [polypeptide binding]; other site 220668002220 dimer interface [polypeptide binding]; other site 220668002221 tetramer interface [polypeptide binding]; other site 220668002222 TPP binding site [chemical binding]; other site 220668002223 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 220668002224 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 220668002225 TPP-binding site [chemical binding]; other site 220668002226 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 220668002227 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668002228 TAP-like protein; Region: Abhydrolase_4; pfam08386 220668002229 Biotin operon repressor [Transcription]; Region: BirA; COG1654 220668002230 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 220668002231 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 220668002232 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 220668002233 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 220668002234 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 220668002235 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 220668002236 catalytic triad [active] 220668002237 catalytic triad [active] 220668002238 oxyanion hole [active] 220668002239 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 220668002240 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 220668002241 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 220668002242 OsmC-like protein; Region: OsmC; cl00767 220668002243 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 220668002244 amino acid transporter; Region: 2A0306; TIGR00909 220668002245 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 220668002246 AP2 domain; Region: AP2; pfam00847 220668002247 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 220668002248 dimer interface [polypeptide binding]; other site 220668002249 pyridoxal binding site [chemical binding]; other site 220668002250 ATP binding site [chemical binding]; other site 220668002251 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 220668002252 active site 220668002253 Ap4A binding cleft/pocket [chemical binding]; other site 220668002254 P4 phosphate binding site; other site 220668002255 nudix motif; other site 220668002256 putative P2/P3 phosphate binding site [ion binding]; other site 220668002257 Guanylate kinase; Region: Guanylate_kin; pfam00625 220668002258 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 220668002259 catalytic site [active] 220668002260 G-X2-G-X-G-K; other site 220668002261 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 220668002262 metal binding site 2 [ion binding]; metal-binding site 220668002263 putative DNA binding helix; other site 220668002264 metal binding site 1 [ion binding]; metal-binding site 220668002265 dimer interface [polypeptide binding]; other site 220668002266 structural Zn2+ binding site [ion binding]; other site 220668002267 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 220668002268 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668002269 active site 220668002270 motif I; other site 220668002271 motif II; other site 220668002272 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 220668002273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668002274 homodimer interface [polypeptide binding]; other site 220668002275 catalytic residue [active] 220668002276 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 220668002277 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 220668002278 NAD binding site [chemical binding]; other site 220668002279 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 220668002280 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 220668002281 Walker A/P-loop; other site 220668002282 ATP binding site [chemical binding]; other site 220668002283 Q-loop/lid; other site 220668002284 ABC transporter signature motif; other site 220668002285 Walker B; other site 220668002286 D-loop; other site 220668002287 H-loop/switch region; other site 220668002288 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 220668002289 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 220668002290 substrate binding pocket [chemical binding]; other site 220668002291 membrane-bound complex binding site; other site 220668002292 hinge residues; other site 220668002293 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 220668002294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668002295 dimer interface [polypeptide binding]; other site 220668002296 conserved gate region; other site 220668002297 putative PBP binding loops; other site 220668002298 ABC-ATPase subunit interface; other site 220668002299 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 220668002300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668002301 dimer interface [polypeptide binding]; other site 220668002302 conserved gate region; other site 220668002303 putative PBP binding loops; other site 220668002304 ABC-ATPase subunit interface; other site 220668002305 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 220668002306 HPr interaction site; other site 220668002307 glycerol kinase (GK) interaction site [polypeptide binding]; other site 220668002308 active site 220668002309 phosphorylation site [posttranslational modification] 220668002310 transcriptional antiterminator BglG; Provisional; Region: PRK09772 220668002311 CAT RNA binding domain; Region: CAT_RBD; smart01061 220668002312 PRD domain; Region: PRD; pfam00874 220668002313 PRD domain; Region: PRD; pfam00874 220668002314 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 220668002315 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 220668002316 active site turn [active] 220668002317 phosphorylation site [posttranslational modification] 220668002318 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 220668002319 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 220668002320 putative active site [active] 220668002321 YdjC motif; other site 220668002322 Mg binding site [ion binding]; other site 220668002323 putative homodimer interface [polypeptide binding]; other site 220668002324 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 220668002325 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 220668002326 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668002327 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 220668002328 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668002329 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 220668002330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668002331 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668002332 putative substrate translocation pore; other site 220668002333 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 220668002334 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668002335 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 220668002336 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 220668002337 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 220668002338 HflX GTPase family; Region: HflX; cd01878 220668002339 G1 box; other site 220668002340 GTP/Mg2+ binding site [chemical binding]; other site 220668002341 Switch I region; other site 220668002342 G2 box; other site 220668002343 G3 box; other site 220668002344 Switch II region; other site 220668002345 G4 box; other site 220668002346 G5 box; other site 220668002347 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 220668002348 nudix motif; other site 220668002349 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 220668002350 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 220668002351 catalytic core [active] 220668002352 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 220668002353 catalytic core [active] 220668002354 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 220668002355 TrkA-N domain; Region: TrkA_N; pfam02254 220668002356 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 220668002357 TrkA-C domain; Region: TrkA_C; pfam02080 220668002358 GrpB protein; Region: GrpB; cl00987 220668002359 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 220668002360 putative active site [active] 220668002361 nucleotide binding site [chemical binding]; other site 220668002362 nudix motif; other site 220668002363 putative metal binding site [ion binding]; other site 220668002364 transcriptional antiterminator BglG; Provisional; Region: PRK09772 220668002365 CAT RNA binding domain; Region: CAT_RBD; smart01061 220668002366 PRD domain; Region: PRD; pfam00874 220668002367 PRD domain; Region: PRD; pfam00874 220668002368 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 220668002369 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 220668002370 active site turn [active] 220668002371 phosphorylation site [posttranslational modification] 220668002372 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 220668002373 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 220668002374 HPr interaction site; other site 220668002375 glycerol kinase (GK) interaction site [polypeptide binding]; other site 220668002376 active site 220668002377 phosphorylation site [posttranslational modification] 220668002378 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 220668002379 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 220668002380 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 220668002381 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 220668002382 Part of AAA domain; Region: AAA_19; pfam13245 220668002383 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 220668002384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 220668002385 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 220668002386 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 220668002387 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 220668002388 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 220668002389 FMN binding site [chemical binding]; other site 220668002390 substrate binding site [chemical binding]; other site 220668002391 putative catalytic residue [active] 220668002392 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 220668002393 ATP-binding site [chemical binding]; other site 220668002394 CoA-binding site [chemical binding]; other site 220668002395 Mg2+-binding site [ion binding]; other site 220668002396 GMP synthase; Reviewed; Region: guaA; PRK00074 220668002397 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 220668002398 AMP/PPi binding site [chemical binding]; other site 220668002399 candidate oxyanion hole; other site 220668002400 catalytic triad [active] 220668002401 potential glutamine specificity residues [chemical binding]; other site 220668002402 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 220668002403 ATP Binding subdomain [chemical binding]; other site 220668002404 Ligand Binding sites [chemical binding]; other site 220668002405 Dimerization subdomain; other site 220668002406 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668002407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668002408 non-specific DNA binding site [nucleotide binding]; other site 220668002409 salt bridge; other site 220668002410 sequence-specific DNA binding site [nucleotide binding]; other site 220668002411 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 220668002412 AAA domain; Region: AAA_12; pfam13087 220668002413 CAAX protease self-immunity; Region: Abi; pfam02517 220668002414 Predicted transcriptional regulators [Transcription]; Region: COG1733 220668002415 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 220668002416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668002417 putative substrate translocation pore; other site 220668002418 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 220668002419 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 220668002420 MORN repeat; Region: MORN; cl14787 220668002421 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 220668002422 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 220668002423 catalytic triad [active] 220668002424 catalytic triad [active] 220668002425 oxyanion hole [active] 220668002426 Predicted membrane protein [Function unknown]; Region: COG2261 220668002427 Carbon starvation protein CstA; Region: CstA; pfam02554 220668002428 Asp23 family; Region: Asp23; pfam03780 220668002429 Asp23 family; Region: Asp23; pfam03780 220668002430 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 220668002431 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 220668002432 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 220668002433 active site 220668002434 methionine cluster; other site 220668002435 phosphorylation site [posttranslational modification] 220668002436 metal binding site [ion binding]; metal-binding site 220668002437 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 220668002438 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 220668002439 Zn binding site [ion binding]; other site 220668002440 ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838 220668002441 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 220668002442 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 220668002443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 220668002444 ATP binding site [chemical binding]; other site 220668002445 putative Mg++ binding site [ion binding]; other site 220668002446 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 220668002447 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 220668002448 HsdM N-terminal domain; Region: HsdM_N; pfam12161 220668002449 Methyltransferase domain; Region: Methyltransf_26; pfam13659 220668002450 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 220668002451 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 220668002452 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 220668002453 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 220668002454 Int/Topo IB signature motif; other site 220668002455 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 220668002456 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 220668002457 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 220668002458 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 220668002459 catalytic core [active] 220668002460 Leucine rich repeat; Region: LRR_8; pfam13855 220668002461 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 220668002462 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 220668002463 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668002464 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668002465 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668002466 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668002467 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668002468 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668002469 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668002470 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668002471 hypothetical protein; Provisional; Region: PRK06762 220668002472 AAA domain; Region: AAA_33; pfam13671 220668002473 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668002474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668002475 non-specific DNA binding site [nucleotide binding]; other site 220668002476 salt bridge; other site 220668002477 sequence-specific DNA binding site [nucleotide binding]; other site 220668002478 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668002479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668002480 non-specific DNA binding site [nucleotide binding]; other site 220668002481 salt bridge; other site 220668002482 sequence-specific DNA binding site [nucleotide binding]; other site 220668002483 Enterocin A Immunity; Region: EntA_Immun; pfam08951 220668002484 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668002485 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668002486 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 220668002487 dimerization interface [polypeptide binding]; other site 220668002488 tricarballylate dehydrogenase; Validated; Region: PRK08274 220668002489 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668002490 FMN-binding domain; Region: FMN_bind; pfam04205 220668002491 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668002492 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 220668002493 putative Zn2+ binding site [ion binding]; other site 220668002494 putative DNA binding site [nucleotide binding]; other site 220668002495 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 220668002496 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 220668002497 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 220668002498 putative dimer interface [polypeptide binding]; other site 220668002499 putative anticodon binding site; other site 220668002500 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 220668002501 homodimer interface [polypeptide binding]; other site 220668002502 motif 1; other site 220668002503 motif 2; other site 220668002504 active site 220668002505 motif 3; other site 220668002506 asparagine synthetase AsnA; Provisional; Region: PRK05425 220668002507 motif 1; other site 220668002508 dimer interface [polypeptide binding]; other site 220668002509 active site 220668002510 motif 2; other site 220668002511 motif 3; other site 220668002512 Peptidase family C69; Region: Peptidase_C69; pfam03577 220668002513 Helix-turn-helix domain; Region: HTH_28; pfam13518 220668002514 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 220668002515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 220668002516 ATP binding site [chemical binding]; other site 220668002517 putative Mg++ binding site [ion binding]; other site 220668002518 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 220668002519 nucleotide binding region [chemical binding]; other site 220668002520 ATP-binding site [chemical binding]; other site 220668002521 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 220668002522 HRDC domain; Region: HRDC; pfam00570 220668002523 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 220668002524 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 220668002525 active site 220668002526 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 220668002527 dimerization interface [polypeptide binding]; other site 220668002528 putative DNA binding site [nucleotide binding]; other site 220668002529 putative Zn2+ binding site [ion binding]; other site 220668002530 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 220668002531 YibE/F-like protein; Region: YibE_F; pfam07907 220668002532 YibE/F-like protein; Region: YibE_F; cl02259 220668002533 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 220668002534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668002535 Coenzyme A binding pocket [chemical binding]; other site 220668002536 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 220668002537 catalytic core [active] 220668002538 Enterocin A Immunity; Region: EntA_Immun; pfam08951 220668002539 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 220668002540 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 220668002541 putative symporter YagG; Provisional; Region: PRK09669; cl15392 220668002542 MFS/sugar transport protein; Region: MFS_2; pfam13347 220668002543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668002544 putative substrate translocation pore; other site 220668002545 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 220668002546 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 220668002547 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 220668002548 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 220668002549 aspartate kinase I; Reviewed; Region: PRK08210 220668002550 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 220668002551 putative catalytic residues [active] 220668002552 putative nucleotide binding site [chemical binding]; other site 220668002553 putative aspartate binding site [chemical binding]; other site 220668002554 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 220668002555 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 220668002556 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 220668002557 active site 220668002558 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 220668002559 dimer interface [polypeptide binding]; other site 220668002560 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 220668002561 Ligand Binding Site [chemical binding]; other site 220668002562 Molecular Tunnel; other site 220668002563 Predicted membrane protein [Function unknown]; Region: COG4392 220668002564 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 220668002565 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 220668002566 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 220668002567 DNA binding residues [nucleotide binding] 220668002568 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 220668002569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668002570 putative substrate translocation pore; other site 220668002571 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 220668002572 DNA binding residues [nucleotide binding] 220668002573 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 220668002574 putative dimer interface [polypeptide binding]; other site 220668002575 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 220668002576 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 220668002577 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 220668002578 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 220668002579 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 220668002580 DNA-binding site [nucleotide binding]; DNA binding site 220668002581 RNA-binding motif; other site 220668002582 Uncharacterized conserved protein [Function unknown]; Region: COG2966 220668002583 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 220668002584 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 220668002585 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 220668002586 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 220668002587 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 220668002588 active site 220668002589 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 220668002590 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 220668002591 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 220668002592 Predicted transcriptional regulator [Transcription]; Region: COG1959 220668002593 Rrf2 family protein; Region: rrf2_super; TIGR00738 220668002594 acetolactate synthase; Reviewed; Region: PRK08617 220668002595 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 220668002596 PYR/PP interface [polypeptide binding]; other site 220668002597 dimer interface [polypeptide binding]; other site 220668002598 TPP binding site [chemical binding]; other site 220668002599 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 220668002600 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 220668002601 TPP-binding site [chemical binding]; other site 220668002602 lysine transporter; Provisional; Region: PRK10836 220668002603 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 220668002604 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 220668002605 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 220668002606 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 220668002607 Substrate-binding site [chemical binding]; other site 220668002608 Substrate specificity [chemical binding]; other site 220668002609 seryl-tRNA synthetase; Provisional; Region: PRK05431 220668002610 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 220668002611 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 220668002612 dimer interface [polypeptide binding]; other site 220668002613 active site 220668002614 motif 1; other site 220668002615 motif 2; other site 220668002616 motif 3; other site 220668002617 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 220668002618 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 220668002619 Clp amino terminal domain; Region: Clp_N; pfam02861 220668002620 Clp amino terminal domain; Region: Clp_N; pfam02861 220668002621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668002622 Walker A motif; other site 220668002623 ATP binding site [chemical binding]; other site 220668002624 Walker B motif; other site 220668002625 arginine finger; other site 220668002626 UvrB/uvrC motif; Region: UVR; pfam02151 220668002627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668002628 Walker A motif; other site 220668002629 ATP binding site [chemical binding]; other site 220668002630 Walker B motif; other site 220668002631 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 220668002632 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668002633 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 220668002634 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 220668002635 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 220668002636 RPB12 interaction site [polypeptide binding]; other site 220668002637 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 220668002638 RPB1 interaction site [polypeptide binding]; other site 220668002639 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 220668002640 RPB10 interaction site [polypeptide binding]; other site 220668002641 RPB11 interaction site [polypeptide binding]; other site 220668002642 RPB3 interaction site [polypeptide binding]; other site 220668002643 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 220668002644 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 220668002645 beta and beta' interface [polypeptide binding]; other site 220668002646 beta' and sigma factor interface [polypeptide binding]; other site 220668002647 Zn-binding [ion binding]; other site 220668002648 active site region [active] 220668002649 catalytic site [active] 220668002650 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 220668002651 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 220668002652 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 220668002653 G-loop; other site 220668002654 DNA binding site [nucleotide binding] 220668002655 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 220668002656 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 220668002657 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 220668002658 S17 interaction site [polypeptide binding]; other site 220668002659 S8 interaction site; other site 220668002660 16S rRNA interaction site [nucleotide binding]; other site 220668002661 streptomycin interaction site [chemical binding]; other site 220668002662 23S rRNA interaction site [nucleotide binding]; other site 220668002663 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 220668002664 30S ribosomal protein S7; Validated; Region: PRK05302 220668002665 elongation factor G; Reviewed; Region: PRK12739 220668002666 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 220668002667 G1 box; other site 220668002668 putative GEF interaction site [polypeptide binding]; other site 220668002669 GTP/Mg2+ binding site [chemical binding]; other site 220668002670 Switch I region; other site 220668002671 G2 box; other site 220668002672 G3 box; other site 220668002673 Switch II region; other site 220668002674 G4 box; other site 220668002675 G5 box; other site 220668002676 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 220668002677 Elongation Factor G, domain II; Region: EFG_II; pfam14492 220668002678 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 220668002679 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 220668002680 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 220668002681 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 220668002682 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 220668002683 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 220668002684 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 220668002685 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 220668002686 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 220668002687 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 220668002688 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 220668002689 putative translocon binding site; other site 220668002690 protein-rRNA interface [nucleotide binding]; other site 220668002691 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 220668002692 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 220668002693 G-X-X-G motif; other site 220668002694 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 220668002695 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 220668002696 23S rRNA interface [nucleotide binding]; other site 220668002697 5S rRNA interface [nucleotide binding]; other site 220668002698 putative antibiotic binding site [chemical binding]; other site 220668002699 L25 interface [polypeptide binding]; other site 220668002700 L27 interface [polypeptide binding]; other site 220668002701 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 220668002702 23S rRNA interface [nucleotide binding]; other site 220668002703 putative translocon interaction site; other site 220668002704 signal recognition particle (SRP54) interaction site; other site 220668002705 L23 interface [polypeptide binding]; other site 220668002706 trigger factor interaction site; other site 220668002707 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 220668002708 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 220668002709 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 220668002710 RNA binding site [nucleotide binding]; other site 220668002711 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 220668002712 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 220668002713 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 220668002714 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 220668002715 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 220668002716 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 220668002717 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 220668002718 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 220668002719 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 220668002720 5S rRNA interface [nucleotide binding]; other site 220668002721 L27 interface [polypeptide binding]; other site 220668002722 23S rRNA interface [nucleotide binding]; other site 220668002723 L5 interface [polypeptide binding]; other site 220668002724 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 220668002725 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 220668002726 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 220668002727 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 220668002728 23S rRNA binding site [nucleotide binding]; other site 220668002729 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 220668002730 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 220668002731 SecY translocase; Region: SecY; pfam00344 220668002732 adenylate kinase; Reviewed; Region: adk; PRK00279 220668002733 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 220668002734 AMP-binding site [chemical binding]; other site 220668002735 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 220668002736 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 220668002737 rRNA binding site [nucleotide binding]; other site 220668002738 predicted 30S ribosome binding site; other site 220668002739 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 220668002740 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 220668002741 30S ribosomal protein S11; Validated; Region: PRK05309 220668002742 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 220668002743 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 220668002744 alphaNTD homodimer interface [polypeptide binding]; other site 220668002745 alphaNTD - beta interaction site [polypeptide binding]; other site 220668002746 alphaNTD - beta' interaction site [polypeptide binding]; other site 220668002747 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 220668002748 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 220668002749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 220668002750 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 220668002751 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 220668002752 Transposase; Region: DDE_Tnp_ISL3; pfam01610 220668002753 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 220668002754 substrate binding pocket [chemical binding]; other site 220668002755 chain length determination region; other site 220668002756 substrate-Mg2+ binding site; other site 220668002757 catalytic residues [active] 220668002758 aspartate-rich region 1; other site 220668002759 active site lid residues [active] 220668002760 aspartate-rich region 2; other site 220668002761 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 220668002762 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 220668002763 trimer interface [polypeptide binding]; other site 220668002764 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 220668002765 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668002766 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 220668002767 FMN-binding domain; Region: FMN_bind; cl01081 220668002768 FMN-binding domain; Region: FMN_bind; cl01081 220668002769 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 220668002770 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 220668002771 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 220668002772 Walker A/P-loop; other site 220668002773 ATP binding site [chemical binding]; other site 220668002774 Q-loop/lid; other site 220668002775 ABC transporter signature motif; other site 220668002776 Walker B; other site 220668002777 D-loop; other site 220668002778 H-loop/switch region; other site 220668002779 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 220668002780 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 220668002781 Walker A/P-loop; other site 220668002782 ATP binding site [chemical binding]; other site 220668002783 Q-loop/lid; other site 220668002784 ABC transporter signature motif; other site 220668002785 Walker B; other site 220668002786 D-loop; other site 220668002787 H-loop/switch region; other site 220668002788 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 220668002789 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 220668002790 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 220668002791 dimerization interface 3.5A [polypeptide binding]; other site 220668002792 active site 220668002793 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 220668002794 23S rRNA interface [nucleotide binding]; other site 220668002795 L3 interface [polypeptide binding]; other site 220668002796 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 220668002797 EDD domain protein, DegV family; Region: DegV; TIGR00762 220668002798 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 220668002799 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 220668002800 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 220668002801 TPP-binding site [chemical binding]; other site 220668002802 dimer interface [polypeptide binding]; other site 220668002803 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 220668002804 PYR/PP interface [polypeptide binding]; other site 220668002805 dimer interface [polypeptide binding]; other site 220668002806 TPP binding site [chemical binding]; other site 220668002807 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 220668002808 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 220668002809 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 220668002810 shikimate binding site; other site 220668002811 NAD(P) binding site [chemical binding]; other site 220668002812 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 220668002813 DAHP synthetase I family; Region: DAHP_synth_1; cl17225 220668002814 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 220668002815 active site 220668002816 dimer interface [polypeptide binding]; other site 220668002817 metal binding site [ion binding]; metal-binding site 220668002818 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 220668002819 anion transporter; Region: dass; TIGR00785 220668002820 transmembrane helices; other site 220668002821 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 220668002822 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 220668002823 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 220668002824 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 220668002825 Cupin domain; Region: Cupin_2; pfam07883 220668002826 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 220668002827 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 220668002828 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 220668002829 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 220668002830 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 220668002831 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 220668002832 ABC-ATPase subunit interface; other site 220668002833 dimer interface [polypeptide binding]; other site 220668002834 putative PBP binding regions; other site 220668002835 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 220668002836 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 220668002837 intersubunit interface [polypeptide binding]; other site 220668002838 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 220668002839 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 220668002840 tetramer (dimer of dimers) interface [polypeptide binding]; other site 220668002841 NAD binding site [chemical binding]; other site 220668002842 dimer interface [polypeptide binding]; other site 220668002843 substrate binding site [chemical binding]; other site 220668002844 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 220668002845 anion transporter; Region: dass; TIGR00785 220668002846 transmembrane helices; other site 220668002847 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 220668002848 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 220668002849 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 220668002850 Malic enzyme, N-terminal domain; Region: malic; pfam00390 220668002851 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 220668002852 NAD(P) binding pocket [chemical binding]; other site 220668002853 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 220668002854 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 220668002855 putative active site [active] 220668002856 (T/H)XGH motif; other site 220668002857 citrate lyase subunit gamma; Provisional; Region: PRK13253 220668002858 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 220668002859 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 220668002860 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 220668002861 fumarate hydratase; Reviewed; Region: fumC; PRK00485 220668002862 Class II fumarases; Region: Fumarase_classII; cd01362 220668002863 active site 220668002864 tetramer interface [polypeptide binding]; other site 220668002865 L-aspartate oxidase; Provisional; Region: PRK06175 220668002866 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 220668002867 holo-ACP synthase CitX; Region: citrate_citX; TIGR03124 220668002868 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668002869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668002870 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 220668002871 dimerization interface [polypeptide binding]; other site 220668002872 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668002873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668002874 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 220668002875 dimerization interface [polypeptide binding]; other site 220668002876 malate dehydrogenase; Provisional; Region: PRK13529 220668002877 Malic enzyme, N-terminal domain; Region: malic; pfam00390 220668002878 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 220668002879 NAD(P) binding pocket [chemical binding]; other site 220668002880 Membrane transport protein; Region: Mem_trans; pfam03547 220668002881 amino acid transporter; Region: 2A0306; TIGR00909 220668002882 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 220668002883 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 220668002884 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 220668002885 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 220668002886 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 220668002887 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 220668002888 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 220668002889 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 220668002890 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 220668002891 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 220668002892 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 220668002893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668002894 Walker A/P-loop; other site 220668002895 ATP binding site [chemical binding]; other site 220668002896 Q-loop/lid; other site 220668002897 ABC transporter signature motif; other site 220668002898 Walker B; other site 220668002899 D-loop; other site 220668002900 H-loop/switch region; other site 220668002901 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 220668002902 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 220668002903 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 220668002904 Walker A/P-loop; other site 220668002905 ATP binding site [chemical binding]; other site 220668002906 Q-loop/lid; other site 220668002907 ABC transporter signature motif; other site 220668002908 Walker B; other site 220668002909 D-loop; other site 220668002910 H-loop/switch region; other site 220668002911 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 220668002912 substrate binding pocket [chemical binding]; other site 220668002913 chain length determination region; other site 220668002914 substrate-Mg2+ binding site; other site 220668002915 catalytic residues [active] 220668002916 aspartate-rich region 1; other site 220668002917 active site lid residues [active] 220668002918 aspartate-rich region 2; other site 220668002919 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 220668002920 putative active site [active] 220668002921 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 220668002922 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 220668002923 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 220668002924 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 220668002925 active site 220668002926 hypothetical protein; Provisional; Region: PRK04164 220668002927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 220668002928 ATP-grasp domain; Region: ATP-grasp_4; cl17255 220668002929 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 220668002930 Part of AAA domain; Region: AAA_19; pfam13245 220668002931 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 220668002932 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 220668002933 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 220668002934 nucleotide binding pocket [chemical binding]; other site 220668002935 K-X-D-G motif; other site 220668002936 catalytic site [active] 220668002937 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 220668002938 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 220668002939 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 220668002940 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 220668002941 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 220668002942 Dimer interface [polypeptide binding]; other site 220668002943 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 220668002944 putative dimer interface [polypeptide binding]; other site 220668002945 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 220668002946 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 220668002947 putative dimer interface [polypeptide binding]; other site 220668002948 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 220668002949 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 220668002950 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 220668002951 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 220668002952 GatB domain; Region: GatB_Yqey; pfam02637 220668002953 putative lipid kinase; Reviewed; Region: PRK13055 220668002954 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 220668002955 TRAM domain; Region: TRAM; pfam01938 220668002956 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 220668002957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 220668002958 S-adenosylmethionine binding site [chemical binding]; other site 220668002959 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668002960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 220668002961 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 220668002962 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 220668002963 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 220668002964 Soluble P-type ATPase [General function prediction only]; Region: COG4087 220668002965 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 220668002966 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668002967 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 220668002968 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 220668002969 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 220668002970 putative active site [active] 220668002971 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 220668002972 active site 220668002973 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 220668002974 DNA-binding site [nucleotide binding]; DNA binding site 220668002975 RNA-binding motif; other site 220668002976 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 220668002977 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 220668002978 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 220668002979 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 220668002980 ATP binding site [chemical binding]; other site 220668002981 putative Mg++ binding site [ion binding]; other site 220668002982 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 220668002983 nucleotide binding region [chemical binding]; other site 220668002984 ATP-binding site [chemical binding]; other site 220668002985 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 220668002986 Ligand Binding Site [chemical binding]; other site 220668002987 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 220668002988 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668002989 glutamate dehydrogenase; Provisional; Region: PRK09414 220668002990 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 220668002991 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 220668002992 NAD(P) binding site [chemical binding]; other site 220668002993 Beta-lactamase; Region: Beta-lactamase; pfam00144 220668002994 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 220668002995 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 220668002996 active site 220668002997 homodimer interface [polypeptide binding]; other site 220668002998 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 220668002999 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 220668003000 amphipathic channel; other site 220668003001 Asn-Pro-Ala signature motifs; other site 220668003002 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 220668003003 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 220668003004 UDP-galactopyranose mutase; Region: GLF; pfam03275 220668003005 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 220668003006 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; cl19952 220668003007 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 220668003008 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 220668003009 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 220668003010 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 220668003011 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 220668003012 Acyltransferase family; Region: Acyl_transf_3; pfam01757 220668003013 Chain length determinant protein; Region: Wzz; pfam02706 220668003014 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 220668003015 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 220668003016 putative ADP-binding pocket [chemical binding]; other site 220668003017 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 220668003018 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 220668003019 Probable Catalytic site; other site 220668003020 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 220668003021 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 220668003022 substrate binding site; other site 220668003023 tetramer interface; other site 220668003024 Sugar-binding cellulase-like; Region: Cellulase-like; cl19200 220668003025 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 220668003026 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 220668003027 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 220668003028 NAD binding site [chemical binding]; other site 220668003029 substrate binding site [chemical binding]; other site 220668003030 homodimer interface [polypeptide binding]; other site 220668003031 active site 220668003032 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 220668003033 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 220668003034 NADP binding site [chemical binding]; other site 220668003035 active site 220668003036 putative substrate binding site [chemical binding]; other site 220668003037 Integrase core domain; Region: rve_3; cl15866 220668003038 Integrase core domain; Region: rve; pfam00665 220668003039 Helix-turn-helix domain; Region: HTH_28; pfam13518 220668003040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 220668003041 Helix-turn-helix domain; Region: HTH_28; pfam13518 220668003042 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 220668003043 Int/Topo IB signature motif; other site 220668003044 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 220668003045 Chain length determinant protein; Region: Wzz; pfam02706 220668003046 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 220668003047 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 220668003048 AAA domain; Region: AAA_31; pfam13614 220668003049 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 220668003050 PHP domain; Region: PHP; pfam02811 220668003051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 220668003052 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 220668003053 NAD(P) binding site [chemical binding]; other site 220668003054 active site 220668003055 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 220668003056 Bacterial sugar transferase; Region: Bac_transf; pfam02397 220668003057 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 220668003058 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 220668003059 putative ADP-binding pocket [chemical binding]; other site 220668003060 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 220668003061 EpsG family; Region: EpsG; pfam14897 220668003062 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 220668003063 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 220668003064 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 220668003065 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 220668003066 putative ADP-binding pocket [chemical binding]; other site 220668003067 RelB antitoxin; Region: RelB; cl01171 220668003068 Uncharacterized conserved protein [Function unknown]; Region: COG4715 220668003069 Helix-turn-helix domain; Region: HTH_28; pfam13518 220668003070 Homeodomain-like domain; Region: HTH_32; pfam13565 220668003071 Helix-turn-helix domain; Region: HTH_28; pfam13518 220668003072 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 220668003073 Transposase; Region: HTH_Tnp_1; cl17663 220668003074 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 220668003075 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 220668003076 Probable Catalytic site; other site 220668003077 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 220668003078 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 220668003079 Probable Catalytic site; other site 220668003080 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 220668003081 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 220668003082 UDP-galactopyranose mutase; Region: GLF; pfam03275 220668003083 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 220668003084 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 220668003085 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 220668003086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 220668003087 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 220668003088 legume lectins; Region: lectin_L-type; cd01951 220668003089 homotetramer interaction site [polypeptide binding]; other site 220668003090 carbohydrate binding site [chemical binding]; other site 220668003091 metal binding site [ion binding]; metal-binding site 220668003092 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668003093 MucBP domain; Region: MucBP; pfam06458 220668003094 MucBP domain; Region: MucBP; pfam06458 220668003095 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 220668003096 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668003097 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 220668003098 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 220668003099 Bacterial sugar transferase; Region: Bac_transf; pfam02397 220668003100 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 220668003101 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 220668003102 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 220668003103 ComK protein; Region: ComK; cl11560 220668003104 recombination regulator RecX; Provisional; Region: recX; PRK14135 220668003105 hypothetical protein; Provisional; Region: PRK13662 220668003106 NlpC/P60 family; Region: NLPC_P60; pfam00877 220668003107 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668003108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668003109 non-specific DNA binding site [nucleotide binding]; other site 220668003110 salt bridge; other site 220668003111 sequence-specific DNA binding site [nucleotide binding]; other site 220668003112 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 220668003113 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 220668003114 tetramer (dimer of dimers) interface [polypeptide binding]; other site 220668003115 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 220668003116 NAD binding site [chemical binding]; other site 220668003117 dimer interface [polypeptide binding]; other site 220668003118 substrate binding site [chemical binding]; other site 220668003119 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 220668003120 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 220668003121 active site 220668003122 nucleotide binding site [chemical binding]; other site 220668003123 HIGH motif; other site 220668003124 KMSKS motif; other site 220668003125 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 220668003126 GntP family permease; Region: GntP_permease; pfam02447 220668003127 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 220668003128 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 220668003129 N- and C-terminal domain interface [polypeptide binding]; other site 220668003130 active site 220668003131 catalytic site [active] 220668003132 metal binding site [ion binding]; metal-binding site 220668003133 carbohydrate binding site [chemical binding]; other site 220668003134 ATP binding site [chemical binding]; other site 220668003135 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 220668003136 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 220668003137 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 220668003138 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 220668003139 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668003140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 220668003141 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 220668003142 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 220668003143 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 220668003144 G1 box; other site 220668003145 putative GEF interaction site [polypeptide binding]; other site 220668003146 GTP/Mg2+ binding site [chemical binding]; other site 220668003147 Switch I region; other site 220668003148 G2 box; other site 220668003149 G3 box; other site 220668003150 Switch II region; other site 220668003151 G4 box; other site 220668003152 G5 box; other site 220668003153 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 220668003154 Elongation Factor G, domain II; Region: EFG_II; pfam14492 220668003155 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668003156 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668003157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668003158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668003159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 220668003160 dimerization interface [polypeptide binding]; other site 220668003161 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 220668003162 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 220668003163 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 220668003164 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 220668003165 peptide binding site [polypeptide binding]; other site 220668003166 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 220668003167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668003168 dimer interface [polypeptide binding]; other site 220668003169 conserved gate region; other site 220668003170 putative PBP binding loops; other site 220668003171 ABC-ATPase subunit interface; other site 220668003172 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 220668003173 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 220668003174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668003175 dimer interface [polypeptide binding]; other site 220668003176 conserved gate region; other site 220668003177 putative PBP binding loops; other site 220668003178 ABC-ATPase subunit interface; other site 220668003179 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 220668003180 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 220668003181 Walker A/P-loop; other site 220668003182 ATP binding site [chemical binding]; other site 220668003183 Q-loop/lid; other site 220668003184 ABC transporter signature motif; other site 220668003185 Walker B; other site 220668003186 D-loop; other site 220668003187 H-loop/switch region; other site 220668003188 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 220668003189 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 220668003190 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 220668003191 Walker A/P-loop; other site 220668003192 ATP binding site [chemical binding]; other site 220668003193 Q-loop/lid; other site 220668003194 ABC transporter signature motif; other site 220668003195 Walker B; other site 220668003196 D-loop; other site 220668003197 H-loop/switch region; other site 220668003198 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 220668003199 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668003200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 220668003201 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 220668003202 Int/Topo IB signature motif; other site 220668003203 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 220668003204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668003205 Walker A motif; other site 220668003206 ATP binding site [chemical binding]; other site 220668003207 Walker B motif; other site 220668003208 arginine finger; other site 220668003209 UvrB/uvrC motif; Region: UVR; pfam02151 220668003210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668003211 Walker A motif; other site 220668003212 ATP binding site [chemical binding]; other site 220668003213 Walker B motif; other site 220668003214 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 220668003215 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 220668003216 dimerization domain swap beta strand [polypeptide binding]; other site 220668003217 regulatory protein interface [polypeptide binding]; other site 220668003218 active site 220668003219 regulatory phosphorylation site [posttranslational modification]; other site 220668003220 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 220668003221 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 220668003222 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 220668003223 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 220668003224 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 220668003225 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 220668003226 putative ADP-binding pocket [chemical binding]; other site 220668003227 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 220668003228 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 220668003229 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 220668003230 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 220668003231 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 220668003232 aminotransferase A; Validated; Region: PRK07683 220668003233 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 220668003234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668003235 homodimer interface [polypeptide binding]; other site 220668003236 catalytic residue [active] 220668003237 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 220668003238 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 220668003239 Sulfatase; Region: Sulfatase; pfam00884 220668003240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 220668003241 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 220668003242 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 220668003243 Transposase; Region: DDE_Tnp_ISL3; pfam01610 220668003244 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 220668003245 active site 220668003246 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 220668003247 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 220668003248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668003249 Coenzyme A binding pocket [chemical binding]; other site 220668003250 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 220668003251 active site 220668003252 metal binding site [ion binding]; metal-binding site 220668003253 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 220668003254 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 220668003255 Ferrochelatase; Region: Ferrochelatase; pfam00762 220668003256 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 220668003257 C-terminal domain interface [polypeptide binding]; other site 220668003258 active site 220668003259 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 220668003260 active site 220668003261 N-terminal domain interface [polypeptide binding]; other site 220668003262 S-methylmethionine transporter; Provisional; Region: PRK11387 220668003263 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 220668003264 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 220668003265 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 220668003266 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 220668003267 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 220668003268 S-adenosylmethionine synthetase; Validated; Region: PRK05250 220668003269 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 220668003270 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 220668003271 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 220668003272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668003273 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668003274 putative substrate translocation pore; other site 220668003275 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 220668003276 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 220668003277 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 220668003278 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 220668003279 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 220668003280 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 220668003281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 220668003282 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 220668003283 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 220668003284 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 220668003285 active site 220668003286 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 220668003287 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 220668003288 active site 220668003289 HIGH motif; other site 220668003290 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 220668003291 KMSKS motif; other site 220668003292 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 220668003293 tRNA binding surface [nucleotide binding]; other site 220668003294 stage V sporulation protein B; Region: spore_V_B; TIGR02900 220668003295 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 220668003296 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 220668003297 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 220668003298 RNA binding surface [nucleotide binding]; other site 220668003299 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 220668003300 active site 220668003301 uracil binding [chemical binding]; other site 220668003302 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 220668003303 putative substrate binding site [chemical binding]; other site 220668003304 putative ATP binding site [chemical binding]; other site 220668003305 dipeptidase PepV; Reviewed; Region: PRK07318 220668003306 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 220668003307 active site 220668003308 metal binding site [ion binding]; metal-binding site 220668003309 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 220668003310 Ligand Binding Site [chemical binding]; other site 220668003311 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 220668003312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668003313 Walker A/P-loop; other site 220668003314 ATP binding site [chemical binding]; other site 220668003315 Q-loop/lid; other site 220668003316 ABC transporter signature motif; other site 220668003317 Walker B; other site 220668003318 D-loop; other site 220668003319 H-loop/switch region; other site 220668003320 TOBE domain; Region: TOBE_2; pfam08402 220668003321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668003322 dimer interface [polypeptide binding]; other site 220668003323 conserved gate region; other site 220668003324 putative PBP binding loops; other site 220668003325 ABC-ATPase subunit interface; other site 220668003326 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 220668003327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668003328 dimer interface [polypeptide binding]; other site 220668003329 conserved gate region; other site 220668003330 putative PBP binding loops; other site 220668003331 ABC-ATPase subunit interface; other site 220668003332 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 220668003333 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 220668003334 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 220668003335 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 220668003336 active site 220668003337 catalytic site [active] 220668003338 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 220668003339 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 220668003340 Substrate-binding site [chemical binding]; other site 220668003341 Substrate specificity [chemical binding]; other site 220668003342 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 220668003343 Predicted membrane protein [Function unknown]; Region: COG1511 220668003344 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 220668003345 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 220668003346 Acyltransferase family; Region: Acyl_transf_3; cl19154 220668003347 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 220668003348 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 220668003349 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 220668003350 Walker A/P-loop; other site 220668003351 ATP binding site [chemical binding]; other site 220668003352 Q-loop/lid; other site 220668003353 ABC transporter signature motif; other site 220668003354 Walker B; other site 220668003355 D-loop; other site 220668003356 H-loop/switch region; other site 220668003357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668003358 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 220668003359 Walker A/P-loop; other site 220668003360 ATP binding site [chemical binding]; other site 220668003361 Q-loop/lid; other site 220668003362 ABC transporter signature motif; other site 220668003363 Walker B; other site 220668003364 D-loop; other site 220668003365 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 220668003366 H-loop/switch region; other site 220668003367 LytTr DNA-binding domain; Region: LytTR; pfam04397 220668003368 Enterocin A Immunity; Region: EntA_Immun; pfam08951 220668003369 methionine sulfoxide reductase A; Provisional; Region: PRK14054 220668003370 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 220668003371 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 220668003372 DNA binding residues [nucleotide binding] 220668003373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 220668003374 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 220668003375 NAD(P) binding site [chemical binding]; other site 220668003376 active site 220668003377 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 220668003378 EamA-like transporter family; Region: EamA; pfam00892 220668003379 EamA-like transporter family; Region: EamA; pfam00892 220668003380 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 220668003381 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 220668003382 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 220668003383 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 220668003384 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 220668003385 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 220668003386 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 220668003387 putative active site [active] 220668003388 putative FMN binding site [chemical binding]; other site 220668003389 putative substrate binding site [chemical binding]; other site 220668003390 putative catalytic residue [active] 220668003391 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 220668003392 catalytic residues [active] 220668003393 Predicted transcriptional regulators [Transcription]; Region: COG1733 220668003394 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 220668003395 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 220668003396 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 220668003397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 220668003398 ATP binding site [chemical binding]; other site 220668003399 Mg2+ binding site [ion binding]; other site 220668003400 G-X-G motif; other site 220668003401 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 220668003402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 220668003403 active site 220668003404 phosphorylation site [posttranslational modification] 220668003405 intermolecular recognition site; other site 220668003406 dimerization interface [polypeptide binding]; other site 220668003407 LytTr DNA-binding domain; Region: LytTR; pfam04397 220668003408 CAAX protease self-immunity; Region: Abi; pfam02517 220668003409 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668003410 MarR family; Region: MarR_2; cl17246 220668003411 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 220668003412 putative DNA binding site [nucleotide binding]; other site 220668003413 putative Zn2+ binding site [ion binding]; other site 220668003414 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 220668003415 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 220668003416 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 220668003417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668003418 Walker A/P-loop; other site 220668003419 ATP binding site [chemical binding]; other site 220668003420 Q-loop/lid; other site 220668003421 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 220668003422 ABC transporter signature motif; other site 220668003423 Walker B; other site 220668003424 D-loop; other site 220668003425 H-loop/switch region; other site 220668003426 GtrA-like protein; Region: GtrA; pfam04138 220668003427 hypothetical protein; Provisional; Region: PRK13673 220668003428 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 220668003429 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 220668003430 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 220668003431 FAD binding site [chemical binding]; other site 220668003432 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 220668003433 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 220668003434 THF binding site; other site 220668003435 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 220668003436 substrate binding site [chemical binding]; other site 220668003437 THF binding site; other site 220668003438 zinc-binding site [ion binding]; other site 220668003439 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 220668003440 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 220668003441 ATP-sulfurylase; Region: ATPS; cd00517 220668003442 active site 220668003443 HXXH motif; other site 220668003444 flexible loop; other site 220668003445 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 220668003446 ligand-binding site [chemical binding]; other site 220668003447 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 220668003448 DHH family; Region: DHH; pfam01368 220668003449 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 220668003450 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 220668003451 transmembrane helices; other site 220668003452 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 220668003453 TrkA-C domain; Region: TrkA_C; pfam02080 220668003454 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 220668003455 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 220668003456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668003457 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 220668003458 Coenzyme A binding pocket [chemical binding]; other site 220668003459 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 220668003460 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 220668003461 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 220668003462 active site 220668003463 HIGH motif; other site 220668003464 KMSK motif region; other site 220668003465 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 220668003466 tRNA binding surface [nucleotide binding]; other site 220668003467 anticodon binding site; other site 220668003468 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 220668003469 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 220668003470 Walker A/P-loop; other site 220668003471 ATP binding site [chemical binding]; other site 220668003472 Q-loop/lid; other site 220668003473 ABC transporter signature motif; other site 220668003474 Walker B; other site 220668003475 D-loop; other site 220668003476 H-loop/switch region; other site 220668003477 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 220668003478 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 220668003479 FtsX-like permease family; Region: FtsX; pfam02687 220668003480 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 220668003481 Transcriptional antiterminator [Transcription]; Region: COG3933 220668003482 PRD domain; Region: PRD; pfam00874 220668003483 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 220668003484 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 220668003485 active site 220668003486 methionine cluster; other site 220668003487 phosphorylation site [posttranslational modification] 220668003488 metal binding site [ion binding]; metal-binding site 220668003489 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 220668003490 active site 220668003491 P-loop; other site 220668003492 phosphorylation site [posttranslational modification] 220668003493 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 220668003494 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 220668003495 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 220668003496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668003497 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668003498 putative substrate translocation pore; other site 220668003499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 220668003500 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 220668003501 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 220668003502 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 220668003503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668003504 DNA-binding site [nucleotide binding]; DNA binding site 220668003505 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 220668003506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668003507 homodimer interface [polypeptide binding]; other site 220668003508 catalytic residue [active] 220668003509 LysE type translocator; Region: LysE; cl00565 220668003510 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 220668003511 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 220668003512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668003513 homodimer interface [polypeptide binding]; other site 220668003514 catalytic residue [active] 220668003515 Arginine repressor [Transcription]; Region: ArgR; COG1438 220668003516 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 220668003517 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 220668003518 Transglycosylase; Region: Transgly; pfam00912 220668003519 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 220668003520 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 220668003521 hypothetical protein; Provisional; Region: PRK13676 220668003522 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 220668003523 active site 220668003524 metal binding site [ion binding]; metal-binding site 220668003525 DNA binding site [nucleotide binding] 220668003526 Uncharacterized conserved protein [Function unknown]; Region: COG4717 220668003527 AAA domain; Region: AAA_23; pfam13476 220668003528 Walker A/P-loop; other site 220668003529 ATP binding site [chemical binding]; other site 220668003530 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 220668003531 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 220668003532 generic binding surface II; other site 220668003533 generic binding surface I; other site 220668003534 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 220668003535 Zn2+ binding site [ion binding]; other site 220668003536 Mg2+ binding site [ion binding]; other site 220668003537 Peptidase family S41; Region: Peptidase_S41; pfam03572 220668003538 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668003539 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668003540 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 220668003541 dimerization interface [polypeptide binding]; other site 220668003542 Predicted flavoprotein [General function prediction only]; Region: COG0431 220668003543 Predicted flavoprotein [General function prediction only]; Region: COG0431 220668003544 FMN-binding domain; Region: FMN_bind; cl01081 220668003545 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 220668003546 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668003547 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 220668003548 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 220668003549 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 220668003550 Ligand binding site; other site 220668003551 Putative Catalytic site; other site 220668003552 DXD motif; other site 220668003553 conserved hypothetical integral membrane protein; Region: TIGR03766 220668003554 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 220668003555 nudix motif; other site 220668003556 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 220668003557 Lumazine binding domain; Region: Lum_binding; pfam00677 220668003558 Lumazine binding domain; Region: Lum_binding; pfam00677 220668003559 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 220668003560 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 220668003561 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 220668003562 dimerization interface [polypeptide binding]; other site 220668003563 active site 220668003564 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 220668003565 homopentamer interface [polypeptide binding]; other site 220668003566 active site 220668003567 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 220668003568 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 220668003569 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 220668003570 ligand binding site [chemical binding]; other site 220668003571 flexible hinge region; other site 220668003572 putative switch regulator; other site 220668003573 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 220668003574 non-specific DNA interactions [nucleotide binding]; other site 220668003575 DNA binding site [nucleotide binding] 220668003576 sequence specific DNA binding site [nucleotide binding]; other site 220668003577 putative cAMP binding site [chemical binding]; other site 220668003578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668003579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 220668003580 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 220668003581 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668003582 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 220668003583 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 220668003584 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668003585 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 220668003586 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 220668003587 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 220668003588 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 220668003589 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668003590 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668003591 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 220668003592 SurA N-terminal domain; Region: SurA_N_3; cl07813 220668003593 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 220668003594 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 220668003595 HIT family signature motif; other site 220668003596 catalytic residue [active] 220668003597 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 220668003598 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 220668003599 Walker A/P-loop; other site 220668003600 ATP binding site [chemical binding]; other site 220668003601 Q-loop/lid; other site 220668003602 ABC transporter signature motif; other site 220668003603 Walker B; other site 220668003604 D-loop; other site 220668003605 H-loop/switch region; other site 220668003606 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 220668003607 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 220668003608 active site 220668003609 substrate binding site [chemical binding]; other site 220668003610 ATP binding site [chemical binding]; other site 220668003611 Phosphotransferase enzyme family; Region: APH; pfam01636 220668003612 Protein of unknown function (DUF1679); Region: DUF1679; pfam07914 220668003613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 220668003614 S-adenosylmethionine binding site [chemical binding]; other site 220668003615 Predicted small secreted protein [Function unknown]; Region: COG5584 220668003616 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 220668003617 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 220668003618 putative tRNA-binding site [nucleotide binding]; other site 220668003619 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 220668003620 AAA-like domain; Region: AAA_10; pfam12846 220668003621 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 220668003622 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 220668003623 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 220668003624 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 220668003625 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 220668003626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 220668003627 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 220668003628 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 220668003629 Transposase; Region: DDE_Tnp_ISL3; pfam01610 220668003630 Virus attachment protein p12 family; Region: P12; pfam12669 220668003631 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 220668003632 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 220668003633 G1 box; other site 220668003634 GTP/Mg2+ binding site [chemical binding]; other site 220668003635 Switch I region; other site 220668003636 G2 box; other site 220668003637 G3 box; other site 220668003638 Switch II region; other site 220668003639 G4 box; other site 220668003640 G5 box; other site 220668003641 Nucleoside recognition; Region: Gate; pfam07670 220668003642 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 220668003643 Nucleoside recognition; Region: Gate; pfam07670 220668003644 FeoA domain; Region: FeoA; pfam04023 220668003645 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 220668003646 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 220668003647 Walker A/P-loop; other site 220668003648 ATP binding site [chemical binding]; other site 220668003649 Q-loop/lid; other site 220668003650 ABC transporter signature motif; other site 220668003651 Walker B; other site 220668003652 D-loop; other site 220668003653 H-loop/switch region; other site 220668003654 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 220668003655 FeS assembly protein SufD; Region: sufD; TIGR01981 220668003656 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 220668003657 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 220668003658 catalytic residue [active] 220668003659 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 220668003660 trimerization site [polypeptide binding]; other site 220668003661 active site 220668003662 FeS assembly protein SufB; Region: sufB; TIGR01980 220668003663 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 220668003664 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 220668003665 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 220668003666 putative ligand binding residues [chemical binding]; other site 220668003667 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 220668003668 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 220668003669 Walker A/P-loop; other site 220668003670 ATP binding site [chemical binding]; other site 220668003671 Q-loop/lid; other site 220668003672 ABC transporter signature motif; other site 220668003673 Walker B; other site 220668003674 D-loop; other site 220668003675 H-loop/switch region; other site 220668003676 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 220668003677 ABC-ATPase subunit interface; other site 220668003678 dimer interface [polypeptide binding]; other site 220668003679 putative PBP binding regions; other site 220668003680 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 220668003681 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 220668003682 MoaE homodimer interface [polypeptide binding]; other site 220668003683 MoaD interaction [polypeptide binding]; other site 220668003684 active site residues [active] 220668003685 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 220668003686 MoaE interaction surface [polypeptide binding]; other site 220668003687 MoeB interaction surface [polypeptide binding]; other site 220668003688 thiocarboxylated glycine; other site 220668003689 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 220668003690 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 220668003691 FeS/SAM binding site; other site 220668003692 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 220668003693 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 220668003694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668003695 putative substrate translocation pore; other site 220668003696 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 220668003697 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668003698 non-specific DNA binding site [nucleotide binding]; other site 220668003699 salt bridge; other site 220668003700 sequence-specific DNA binding site [nucleotide binding]; other site 220668003701 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 220668003702 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 220668003703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 220668003704 active site 220668003705 phosphorylation site [posttranslational modification] 220668003706 intermolecular recognition site; other site 220668003707 dimerization interface [polypeptide binding]; other site 220668003708 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 220668003709 DNA binding residues [nucleotide binding] 220668003710 dimerization interface [polypeptide binding]; other site 220668003711 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 220668003712 Histidine kinase; Region: HisKA_3; pfam07730 220668003713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 220668003714 ATP binding site [chemical binding]; other site 220668003715 Mg2+ binding site [ion binding]; other site 220668003716 G-X-G motif; other site 220668003717 GAF domain; Region: GAF_2; pfam13185 220668003718 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 220668003719 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 220668003720 GTP binding site; other site 220668003721 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 220668003722 trimer interface [polypeptide binding]; other site 220668003723 dimer interface [polypeptide binding]; other site 220668003724 putative active site [active] 220668003725 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 220668003726 Walker A motif; other site 220668003727 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 220668003728 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 220668003729 dimer interface [polypeptide binding]; other site 220668003730 putative functional site; other site 220668003731 putative MPT binding site; other site 220668003732 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 220668003733 MPT binding site; other site 220668003734 trimer interface [polypeptide binding]; other site 220668003735 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 220668003736 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 220668003737 ATP binding site [chemical binding]; other site 220668003738 substrate interface [chemical binding]; other site 220668003739 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 220668003740 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 220668003741 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 220668003742 [4Fe-4S] binding site [ion binding]; other site 220668003743 molybdopterin cofactor binding site [chemical binding]; other site 220668003744 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 220668003745 molybdopterin cofactor binding site; other site 220668003746 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 220668003747 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 220668003748 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 220668003749 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 220668003750 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 220668003751 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 220668003752 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668003753 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668003754 sequence-specific DNA binding site [nucleotide binding]; other site 220668003755 salt bridge; other site 220668003756 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 220668003757 DNA polymerase I; Provisional; Region: PRK05755 220668003758 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 220668003759 active site 220668003760 metal binding site 1 [ion binding]; metal-binding site 220668003761 putative 5' ssDNA interaction site; other site 220668003762 metal binding site 3; metal-binding site 220668003763 metal binding site 2 [ion binding]; metal-binding site 220668003764 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 220668003765 putative DNA binding site [nucleotide binding]; other site 220668003766 putative metal binding site [ion binding]; other site 220668003767 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 220668003768 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 220668003769 active site 220668003770 DNA binding site [nucleotide binding] 220668003771 catalytic site [active] 220668003772 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 220668003773 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 220668003774 DNA binding site [nucleotide binding] 220668003775 catalytic residue [active] 220668003776 H2TH interface [polypeptide binding]; other site 220668003777 putative catalytic residues [active] 220668003778 turnover-facilitating residue; other site 220668003779 intercalation triad [nucleotide binding]; other site 220668003780 8OG recognition residue [nucleotide binding]; other site 220668003781 putative reading head residues; other site 220668003782 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 220668003783 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 220668003784 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 220668003785 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 220668003786 CoA-binding site [chemical binding]; other site 220668003787 ATP-binding [chemical binding]; other site 220668003788 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 220668003789 ATP cone domain; Region: ATP-cone; pfam03477 220668003790 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 220668003791 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 220668003792 primosomal protein DnaI; Reviewed; Region: PRK08939 220668003793 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 220668003794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668003795 Walker A motif; other site 220668003796 ATP binding site [chemical binding]; other site 220668003797 Walker B motif; other site 220668003798 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 220668003799 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 220668003800 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 220668003801 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 220668003802 active site 220668003803 dimer interface [polypeptide binding]; other site 220668003804 motif 1; other site 220668003805 motif 2; other site 220668003806 motif 3; other site 220668003807 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 220668003808 anticodon binding site; other site 220668003809 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 220668003810 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 220668003811 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 220668003812 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 220668003813 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 220668003814 23S rRNA binding site [nucleotide binding]; other site 220668003815 L21 binding site [polypeptide binding]; other site 220668003816 L13 binding site [polypeptide binding]; other site 220668003817 recombination factor protein RarA; Reviewed; Region: PRK13342 220668003818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668003819 Walker A motif; other site 220668003820 ATP binding site [chemical binding]; other site 220668003821 Walker B motif; other site 220668003822 arginine finger; other site 220668003823 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 220668003824 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 220668003825 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 220668003826 putative NAD(P) binding site [chemical binding]; other site 220668003827 dimer interface [polypeptide binding]; other site 220668003828 Predicted transcriptional regulators [Transcription]; Region: COG1733 220668003829 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 220668003830 N-glycosyltransferase; Provisional; Region: PRK11204 220668003831 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 220668003832 DXD motif; other site 220668003833 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 220668003834 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668003835 active site 220668003836 motif I; other site 220668003837 motif II; other site 220668003838 GTPase YqeH; Provisional; Region: PRK13796 220668003839 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 220668003840 GTP/Mg2+ binding site [chemical binding]; other site 220668003841 G4 box; other site 220668003842 G5 box; other site 220668003843 G1 box; other site 220668003844 Switch I region; other site 220668003845 G2 box; other site 220668003846 G3 box; other site 220668003847 Switch II region; other site 220668003848 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 220668003849 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 220668003850 active site 220668003851 (T/H)XGH motif; other site 220668003852 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 220668003853 Zn2+ binding site [ion binding]; other site 220668003854 Mg2+ binding site [ion binding]; other site 220668003855 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 220668003856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 220668003857 S-adenosylmethionine binding site [chemical binding]; other site 220668003858 hypothetical protein; Provisional; Region: PRK13670 220668003859 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 220668003860 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 220668003861 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 220668003862 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 220668003863 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 220668003864 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 220668003865 Transposase; Region: DDE_Tnp_ISL3; pfam01610 220668003866 Predicted membrane protein [Function unknown]; Region: COG3212 220668003867 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 220668003868 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 220668003869 Cation efflux family; Region: Cation_efflux; cl00316 220668003870 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 220668003871 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 220668003872 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 220668003873 recombination factor protein RarA; Reviewed; Region: PRK13342 220668003874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668003875 Walker A motif; other site 220668003876 ATP binding site [chemical binding]; other site 220668003877 Walker B motif; other site 220668003878 arginine finger; other site 220668003879 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 220668003880 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 220668003881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 220668003882 active site 220668003883 phosphorylation site [posttranslational modification] 220668003884 intermolecular recognition site; other site 220668003885 dimerization interface [polypeptide binding]; other site 220668003886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 220668003887 DNA binding site [nucleotide binding] 220668003888 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 220668003889 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 220668003890 dimerization interface [polypeptide binding]; other site 220668003891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 220668003892 dimer interface [polypeptide binding]; other site 220668003893 phosphorylation site [posttranslational modification] 220668003894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 220668003895 ATP binding site [chemical binding]; other site 220668003896 Mg2+ binding site [ion binding]; other site 220668003897 G-X-G motif; other site 220668003898 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 220668003899 putative active site [active] 220668003900 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 220668003901 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 220668003902 Walker A/P-loop; other site 220668003903 ATP binding site [chemical binding]; other site 220668003904 Q-loop/lid; other site 220668003905 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 220668003906 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 220668003907 ABC transporter signature motif; other site 220668003908 Walker B; other site 220668003909 D-loop; other site 220668003910 H-loop/switch region; other site 220668003911 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 220668003912 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 220668003913 active site 220668003914 metal binding site [ion binding]; metal-binding site 220668003915 DNA binding site [nucleotide binding] 220668003916 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 220668003917 Predicted integral membrane protein [Function unknown]; Region: COG5658 220668003918 SdpI/YhfL protein family; Region: SdpI; pfam13630 220668003919 OxaA-like protein precursor; Provisional; Region: PRK02463 220668003920 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 220668003921 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 220668003922 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 220668003923 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 220668003924 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 220668003925 HD domain; Region: HD; pfam01966 220668003926 Predicted transcriptional regulators [Transcription]; Region: COG1733 220668003927 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 220668003928 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 220668003929 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 220668003930 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 220668003931 dimer interface [polypeptide binding]; other site 220668003932 motif 1; other site 220668003933 active site 220668003934 motif 2; other site 220668003935 motif 3; other site 220668003936 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 220668003937 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 220668003938 putative tRNA-binding site [nucleotide binding]; other site 220668003939 B3/4 domain; Region: B3_4; pfam03483 220668003940 tRNA synthetase B5 domain; Region: B5; smart00874 220668003941 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 220668003942 dimer interface [polypeptide binding]; other site 220668003943 motif 1; other site 220668003944 motif 3; other site 220668003945 motif 2; other site 220668003946 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 220668003947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 220668003948 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 220668003949 dimerization interface [polypeptide binding]; other site 220668003950 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 220668003951 ATP-binding site [chemical binding]; other site 220668003952 Sugar specificity; other site 220668003953 Pyrimidine base specificity; other site 220668003954 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 220668003955 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 220668003956 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 220668003957 LytTr DNA-binding domain; Region: LytTR; smart00850 220668003958 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 220668003959 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 220668003960 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 220668003961 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 220668003962 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 220668003963 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 220668003964 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 220668003965 Rhomboid family; Region: Rhomboid; pfam01694 220668003966 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 220668003967 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 220668003968 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 220668003969 nucleotide binding site [chemical binding]; other site 220668003970 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 220668003971 conserved cys residue [active] 220668003972 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 220668003973 active site residue [active] 220668003974 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 220668003975 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 220668003976 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 220668003977 active site 220668003978 catalytic site [active] 220668003979 metal binding site [ion binding]; metal-binding site 220668003980 dimer interface [polypeptide binding]; other site 220668003981 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 220668003982 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 220668003983 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 220668003984 DNA binding residues [nucleotide binding] 220668003985 putative dimer interface [polypeptide binding]; other site 220668003986 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 220668003987 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 220668003988 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 220668003989 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 220668003990 dUTPase; Region: dUTPase_2; pfam08761 220668003991 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 220668003992 active site 220668003993 homodimer interface [polypeptide binding]; other site 220668003994 metal binding site [ion binding]; metal-binding site 220668003995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668003996 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 220668003997 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 220668003998 Protein of unknown function (DUF464); Region: DUF464; pfam04327 220668003999 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 220668004000 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 220668004001 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 220668004002 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 220668004003 active site 220668004004 elongation factor P; Validated; Region: PRK00529 220668004005 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 220668004006 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 220668004007 RNA binding site [nucleotide binding]; other site 220668004008 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 220668004009 RNA binding site [nucleotide binding]; other site 220668004010 Asp23 family; Region: Asp23; pfam03780 220668004011 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 220668004012 putative RNA binding site [nucleotide binding]; other site 220668004013 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 220668004014 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 220668004015 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 220668004016 homodimer interface [polypeptide binding]; other site 220668004017 NADP binding site [chemical binding]; other site 220668004018 substrate binding site [chemical binding]; other site 220668004019 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 220668004020 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 220668004021 generic binding surface II; other site 220668004022 generic binding surface I; other site 220668004023 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 220668004024 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 220668004025 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 220668004026 substrate binding pocket [chemical binding]; other site 220668004027 chain length determination region; other site 220668004028 substrate-Mg2+ binding site; other site 220668004029 catalytic residues [active] 220668004030 aspartate-rich region 1; other site 220668004031 active site lid residues [active] 220668004032 aspartate-rich region 2; other site 220668004033 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 220668004034 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 220668004035 RNA binding surface [nucleotide binding]; other site 220668004036 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 220668004037 Arginine repressor [Transcription]; Region: ArgR; COG1438 220668004038 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 220668004039 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 220668004040 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 220668004041 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 220668004042 Walker A/P-loop; other site 220668004043 ATP binding site [chemical binding]; other site 220668004044 Q-loop/lid; other site 220668004045 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 220668004046 ABC transporter signature motif; other site 220668004047 Walker B; other site 220668004048 D-loop; other site 220668004049 H-loop/switch region; other site 220668004050 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 220668004051 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 220668004052 Walker A/P-loop; other site 220668004053 ATP binding site [chemical binding]; other site 220668004054 Q-loop/lid; other site 220668004055 ABC transporter signature motif; other site 220668004056 Walker B; other site 220668004057 D-loop; other site 220668004058 H-loop/switch region; other site 220668004059 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 220668004060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668004061 dimer interface [polypeptide binding]; other site 220668004062 conserved gate region; other site 220668004063 putative PBP binding loops; other site 220668004064 ABC-ATPase subunit interface; other site 220668004065 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 220668004066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668004067 dimer interface [polypeptide binding]; other site 220668004068 conserved gate region; other site 220668004069 putative PBP binding loops; other site 220668004070 ABC-ATPase subunit interface; other site 220668004071 Guanylate kinase; Region: Guanylate_kin; pfam00625 220668004072 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 220668004073 catalytic site [active] 220668004074 G-X2-G-X-G-K; other site 220668004075 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 220668004076 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 220668004077 Flavoprotein; Region: Flavoprotein; cl19190 220668004078 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 220668004079 primosome assembly protein PriA; Validated; Region: PRK05580 220668004080 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 220668004081 ATP binding site [chemical binding]; other site 220668004082 putative Mg++ binding site [ion binding]; other site 220668004083 helicase superfamily c-terminal domain; Region: HELICc; smart00490 220668004084 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 220668004085 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 220668004086 putative active site [active] 220668004087 substrate binding site [chemical binding]; other site 220668004088 putative cosubstrate binding site; other site 220668004089 catalytic site [active] 220668004090 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 220668004091 substrate binding site [chemical binding]; other site 220668004092 16S rRNA methyltransferase B; Provisional; Region: PRK14902 220668004093 NusB family; Region: NusB; pfam01029 220668004094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 220668004095 S-adenosylmethionine binding site [chemical binding]; other site 220668004096 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 220668004097 active site 220668004098 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 220668004099 Catalytic domain of Protein Kinases; Region: PKc; cd00180 220668004100 active site 220668004101 ATP binding site [chemical binding]; other site 220668004102 substrate binding site [chemical binding]; other site 220668004103 activation loop (A-loop); other site 220668004104 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 220668004105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 220668004106 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 220668004107 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 220668004108 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 220668004109 GTPase RsgA; Reviewed; Region: PRK00098 220668004110 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 220668004111 RNA binding site [nucleotide binding]; other site 220668004112 homodimer interface [polypeptide binding]; other site 220668004113 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 220668004114 GTPase/Zn-binding domain interface [polypeptide binding]; other site 220668004115 GTP/Mg2+ binding site [chemical binding]; other site 220668004116 G4 box; other site 220668004117 G5 box; other site 220668004118 G1 box; other site 220668004119 Switch I region; other site 220668004120 G2 box; other site 220668004121 G3 box; other site 220668004122 Switch II region; other site 220668004123 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 220668004124 substrate binding site [chemical binding]; other site 220668004125 hexamer interface [polypeptide binding]; other site 220668004126 metal binding site [ion binding]; metal-binding site 220668004127 Thiamine pyrophosphokinase; Region: TPK; cd07995 220668004128 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 220668004129 active site 220668004130 dimerization interface [polypeptide binding]; other site 220668004131 thiamine binding site [chemical binding]; other site 220668004132 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 220668004133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 220668004134 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 220668004135 DAK2 domain; Region: Dak2; pfam02734 220668004136 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 220668004137 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 220668004138 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 220668004139 generic binding surface II; other site 220668004140 ssDNA binding site; other site 220668004141 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 220668004142 ATP binding site [chemical binding]; other site 220668004143 putative Mg++ binding site [ion binding]; other site 220668004144 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 220668004145 nucleotide binding region [chemical binding]; other site 220668004146 ATP-binding site [chemical binding]; other site 220668004147 putative phosphate acyltransferase; Provisional; Region: PRK05331 220668004148 acyl carrier protein; Provisional; Region: acpP; PRK00982 220668004149 ribonuclease III; Reviewed; Region: rnc; PRK00102 220668004150 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 220668004151 dimerization interface [polypeptide binding]; other site 220668004152 active site 220668004153 metal binding site [ion binding]; metal-binding site 220668004154 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 220668004155 dsRNA binding site [nucleotide binding]; other site 220668004156 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 220668004157 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 220668004158 Walker A/P-loop; other site 220668004159 ATP binding site [chemical binding]; other site 220668004160 Q-loop/lid; other site 220668004161 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 220668004162 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 220668004163 ABC transporter signature motif; other site 220668004164 Walker B; other site 220668004165 D-loop; other site 220668004166 H-loop/switch region; other site 220668004167 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 220668004168 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 220668004169 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 220668004170 P loop; other site 220668004171 GTP binding site [chemical binding]; other site 220668004172 putative DNA-binding protein; Validated; Region: PRK00118 220668004173 signal recognition particle protein; Provisional; Region: PRK10867 220668004174 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 220668004175 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 220668004176 P loop; other site 220668004177 GTP binding site [chemical binding]; other site 220668004178 Signal peptide binding domain; Region: SRP_SPB; pfam02978 220668004179 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 220668004180 KH domain; Region: KH_4; pfam13083 220668004181 G-X-X-G motif; other site 220668004182 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 220668004183 RimM N-terminal domain; Region: RimM; pfam01782 220668004184 PRC-barrel domain; Region: PRC; pfam05239 220668004185 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 220668004186 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 220668004187 Enterocin A Immunity; Region: EntA_Immun; pfam08951 220668004188 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 220668004189 MucBP domain; Region: MucBP; pfam06458 220668004190 MucBP domain; Region: MucBP; pfam06458 220668004191 MucBP domain; Region: MucBP; pfam06458 220668004192 AP2 domain; Region: AP2; pfam00847 220668004193 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 220668004194 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 220668004195 Walker A/P-loop; other site 220668004196 ATP binding site [chemical binding]; other site 220668004197 Q-loop/lid; other site 220668004198 ABC transporter signature motif; other site 220668004199 Walker B; other site 220668004200 D-loop; other site 220668004201 H-loop/switch region; other site 220668004202 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 220668004203 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 220668004204 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 220668004205 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 220668004206 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 220668004207 glutamine binding [chemical binding]; other site 220668004208 catalytic triad [active] 220668004209 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 220668004210 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 220668004211 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 220668004212 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 220668004213 active site 220668004214 ribulose/triose binding site [chemical binding]; other site 220668004215 phosphate binding site [ion binding]; other site 220668004216 substrate (anthranilate) binding pocket [chemical binding]; other site 220668004217 product (indole) binding pocket [chemical binding]; other site 220668004218 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 220668004219 active site 220668004220 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 220668004221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668004222 catalytic residue [active] 220668004223 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 220668004224 substrate binding site [chemical binding]; other site 220668004225 active site 220668004226 catalytic residues [active] 220668004227 heterodimer interface [polypeptide binding]; other site 220668004228 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 220668004229 catalytic triad [active] 220668004230 conserved cis-peptide bond; other site 220668004231 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 220668004232 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 220668004233 NAD(P) binding site [chemical binding]; other site 220668004234 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 220668004235 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 220668004236 metal binding site [ion binding]; metal-binding site 220668004237 dimer interface [polypeptide binding]; other site 220668004238 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 220668004239 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 220668004240 NAD(P) binding site [chemical binding]; other site 220668004241 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 220668004242 short chain dehydrogenase; Validated; Region: PRK06182 220668004243 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 220668004244 NADP binding site [chemical binding]; other site 220668004245 active site 220668004246 steroid binding site; other site 220668004247 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 220668004248 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 220668004249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 220668004250 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 220668004251 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 220668004252 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 220668004253 dimer interface [polypeptide binding]; other site 220668004254 active site 220668004255 CoA binding pocket [chemical binding]; other site 220668004256 acyl carrier protein; Provisional; Region: acpP; PRK00982 220668004257 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 220668004258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 220668004259 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 220668004260 NAD(P) binding site [chemical binding]; other site 220668004261 active site 220668004262 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 220668004263 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 220668004264 dimer interface [polypeptide binding]; other site 220668004265 active site 220668004266 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 220668004267 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 220668004268 carboxyltransferase (CT) interaction site; other site 220668004269 biotinylation site [posttranslational modification]; other site 220668004270 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 220668004271 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 220668004272 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 220668004273 ATP-grasp domain; Region: ATP-grasp_4; cl17255 220668004274 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 220668004275 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 220668004276 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 220668004277 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 220668004278 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 220668004279 NAD binding site [chemical binding]; other site 220668004280 homotetramer interface [polypeptide binding]; other site 220668004281 homodimer interface [polypeptide binding]; other site 220668004282 substrate binding site [chemical binding]; other site 220668004283 active site 220668004284 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 220668004285 Protein of unknown function (DUF554); Region: DUF554; pfam04474 220668004286 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668004287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668004288 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 220668004289 dimerization interface [polypeptide binding]; other site 220668004290 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 220668004291 GTPase RsgA; Reviewed; Region: PRK01889 220668004292 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 220668004293 RNA binding site [nucleotide binding]; other site 220668004294 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 220668004295 GTPase/Zn-binding domain interface [polypeptide binding]; other site 220668004296 GTP/Mg2+ binding site [chemical binding]; other site 220668004297 G4 box; other site 220668004298 G5 box; other site 220668004299 G1 box; other site 220668004300 Switch I region; other site 220668004301 G2 box; other site 220668004302 G3 box; other site 220668004303 Switch II region; other site 220668004304 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668004305 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 220668004306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668004307 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668004308 putative substrate translocation pore; other site 220668004309 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u2; cd03402 220668004310 prohibitin homologues; Region: PHB; smart00244 220668004311 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 220668004312 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668004313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 220668004314 Enterocin A Immunity; Region: EntA_Immun; pfam08951 220668004315 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 220668004316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 220668004317 S-adenosylmethionine binding site [chemical binding]; other site 220668004318 Chitin binding domain; Region: Chitin_bind_3; pfam03067 220668004319 Uncharacterized conserved protein [Function unknown]; Region: COG1359 220668004320 TspO/MBR family; Region: TspO_MBR; pfam03073 220668004321 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 220668004322 Ligand Binding Site [chemical binding]; other site 220668004323 Protein of unknown function (DUF805); Region: DUF805; pfam05656 220668004324 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 220668004325 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 220668004326 Predicted membrane protein [Function unknown]; Region: COG2261 220668004327 CsbD-like; Region: CsbD; cl17424 220668004328 Peptidase family C69; Region: Peptidase_C69; pfam03577 220668004329 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 220668004330 active site 1 [active] 220668004331 dimer interface [polypeptide binding]; other site 220668004332 hexamer interface [polypeptide binding]; other site 220668004333 active site 2 [active] 220668004334 diaminopimelate decarboxylase; Region: lysA; TIGR01048 220668004335 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 220668004336 active site 220668004337 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 220668004338 substrate binding site [chemical binding]; other site 220668004339 catalytic residues [active] 220668004340 dimer interface [polypeptide binding]; other site 220668004341 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 220668004342 putative active site [active] 220668004343 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 220668004344 Ion channel; Region: Ion_trans_2; pfam07885 220668004345 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 220668004346 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 220668004347 inhibitor-cofactor binding pocket; inhibition site 220668004348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668004349 catalytic residue [active] 220668004350 amino acid transporter; Region: 2A0306; TIGR00909 220668004351 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 220668004352 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 220668004353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668004354 active site 220668004355 motif I; other site 220668004356 motif II; other site 220668004357 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 220668004358 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 220668004359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 220668004360 S-adenosylmethionine binding site [chemical binding]; other site 220668004361 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 220668004362 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 220668004363 Double zinc ribbon; Region: DZR; pfam12773 220668004364 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 220668004365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668004366 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 220668004367 putative substrate translocation pore; other site 220668004368 maltose phosphorylase; Provisional; Region: PRK13807 220668004369 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 220668004370 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 220668004371 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 220668004372 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 220668004373 active site 220668004374 catalytic residues [active] 220668004375 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 220668004376 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 220668004377 homotetramer interface [polypeptide binding]; other site 220668004378 FMN binding site [chemical binding]; other site 220668004379 homodimer contacts [polypeptide binding]; other site 220668004380 putative active site [active] 220668004381 putative substrate binding site [chemical binding]; other site 220668004382 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 220668004383 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 220668004384 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 220668004385 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 220668004386 diphosphomevalonate decarboxylase; Region: PLN02407 220668004387 mevalonate kinase; Region: mevalon_kin; TIGR00549 220668004388 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 220668004389 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 220668004390 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 220668004391 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 220668004392 active site 220668004393 catalytic site [active] 220668004394 substrate binding site [chemical binding]; other site 220668004395 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 220668004396 ATP binding site [chemical binding]; other site 220668004397 AAA domain; Region: AAA_22; pfam13401 220668004398 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 220668004399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 220668004400 aspartate aminotransferase; Provisional; Region: PRK05764 220668004401 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 220668004402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668004403 homodimer interface [polypeptide binding]; other site 220668004404 catalytic residue [active] 220668004405 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 220668004406 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 220668004407 putative dimer interface [polypeptide binding]; other site 220668004408 putative anticodon binding site; other site 220668004409 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 220668004410 homodimer interface [polypeptide binding]; other site 220668004411 motif 1; other site 220668004412 motif 2; other site 220668004413 active site 220668004414 motif 3; other site 220668004415 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 220668004416 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 220668004417 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 220668004418 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 220668004419 Walker A/P-loop; other site 220668004420 ATP binding site [chemical binding]; other site 220668004421 Q-loop/lid; other site 220668004422 ABC transporter signature motif; other site 220668004423 Walker B; other site 220668004424 D-loop; other site 220668004425 H-loop/switch region; other site 220668004426 NIL domain; Region: NIL; pfam09383 220668004427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668004428 dimer interface [polypeptide binding]; other site 220668004429 conserved gate region; other site 220668004430 putative PBP binding loops; other site 220668004431 ABC-ATPase subunit interface; other site 220668004432 NLPA lipoprotein; Region: Lipoprotein_9; cl19159 220668004433 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 220668004434 Ligand Binding Site [chemical binding]; other site 220668004435 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 220668004436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668004437 dimer interface [polypeptide binding]; other site 220668004438 conserved gate region; other site 220668004439 putative PBP binding loops; other site 220668004440 ABC-ATPase subunit interface; other site 220668004441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668004442 dimer interface [polypeptide binding]; other site 220668004443 conserved gate region; other site 220668004444 putative PBP binding loops; other site 220668004445 ABC-ATPase subunit interface; other site 220668004446 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 220668004447 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 220668004448 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 220668004449 Walker A/P-loop; other site 220668004450 ATP binding site [chemical binding]; other site 220668004451 Q-loop/lid; other site 220668004452 ABC transporter signature motif; other site 220668004453 Walker B; other site 220668004454 D-loop; other site 220668004455 H-loop/switch region; other site 220668004456 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 220668004457 Transglycosylase; Region: Transgly; pfam00912 220668004458 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 220668004459 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 220668004460 hypothetical protein; Provisional; Region: PRK13660 220668004461 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 220668004462 cell division protein GpsB; Provisional; Region: PRK14127 220668004463 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 220668004464 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 220668004465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 220668004466 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 220668004467 dimerization interface [polypeptide binding]; other site 220668004468 putative DNA binding site [nucleotide binding]; other site 220668004469 putative Zn2+ binding site [ion binding]; other site 220668004470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668004471 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668004472 putative substrate translocation pore; other site 220668004473 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 220668004474 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 220668004475 SnoaL-like domain; Region: SnoaL_2; pfam12680 220668004476 putative glycosyl transferase; Provisional; Region: PRK10073 220668004477 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 220668004478 active site 220668004479 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 220668004480 putative dimer interface [polypeptide binding]; other site 220668004481 catalytic triad [active] 220668004482 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 220668004483 active site 220668004484 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 220668004485 putative dimer interface [polypeptide binding]; other site 220668004486 catalytic triad [active] 220668004487 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 220668004488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668004489 Walker A/P-loop; other site 220668004490 ATP binding site [chemical binding]; other site 220668004491 Q-loop/lid; other site 220668004492 ABC transporter signature motif; other site 220668004493 Walker B; other site 220668004494 D-loop; other site 220668004495 H-loop/switch region; other site 220668004496 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 220668004497 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668004498 FAD dependent oxidoreductase; Region: DAO; pfam01266 220668004499 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 220668004500 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668004501 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 220668004502 RNA/DNA hybrid binding site [nucleotide binding]; other site 220668004503 active site 220668004504 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 220668004505 Potassium binding sites [ion binding]; other site 220668004506 Cesium cation binding sites [ion binding]; other site 220668004507 lipoprotein signal peptidase; Provisional; Region: PRK14797 220668004508 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 220668004509 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 220668004510 RNA binding surface [nucleotide binding]; other site 220668004511 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 220668004512 active site 220668004513 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 220668004514 active site 220668004515 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 220668004516 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 220668004517 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 220668004518 catalytic site [active] 220668004519 subunit interface [polypeptide binding]; other site 220668004520 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 220668004521 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 220668004522 ATP-grasp domain; Region: ATP-grasp_4; cl17255 220668004523 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 220668004524 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 220668004525 catalytic core [active] 220668004526 Domain of unknown function (DU1801); Region: DUF1801; cl17490 220668004527 Chloramphenicol acetyltransferase; Region: CAT; smart01059 220668004528 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 220668004529 GIY-YIG motif/motif A; other site 220668004530 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 220668004531 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 220668004532 nudix motif; other site 220668004533 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 220668004534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668004535 Walker A/P-loop; other site 220668004536 ATP binding site [chemical binding]; other site 220668004537 Q-loop/lid; other site 220668004538 ABC transporter signature motif; other site 220668004539 Walker B; other site 220668004540 D-loop; other site 220668004541 H-loop/switch region; other site 220668004542 Acyltransferase family; Region: Acyl_transf_3; cl19154 220668004543 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 220668004544 Domain of unknown function (DUF814); Region: DUF814; pfam05670 220668004545 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668004546 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 220668004547 EDD domain protein, DegV family; Region: DegV; TIGR00762 220668004548 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668004549 Coenzyme A binding pocket [chemical binding]; other site 220668004550 Protein of unknown function (DUF975); Region: DUF975; cl10504 220668004551 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 220668004552 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 220668004553 nucleotide binding site/active site [active] 220668004554 HIT family signature motif; other site 220668004555 catalytic residue [active] 220668004556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668004557 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668004558 putative substrate translocation pore; other site 220668004559 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 220668004560 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 220668004561 Predicted membrane protein [Function unknown]; Region: COG2035 220668004562 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 220668004563 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 220668004564 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 220668004565 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 220668004566 substrate binding site; other site 220668004567 dimer interface; other site 220668004568 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 220668004569 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 220668004570 putative NAD(P) binding site [chemical binding]; other site 220668004571 putative catalytic Zn binding site [ion binding]; other site 220668004572 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 220668004573 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 220668004574 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 220668004575 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 220668004576 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 220668004577 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668004578 Coenzyme A binding pocket [chemical binding]; other site 220668004579 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668004580 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 220668004581 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 220668004582 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 220668004583 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 220668004584 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 220668004585 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 220668004586 active site 220668004587 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_4; pfam13495 220668004588 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 220668004589 methionine sulfoxide reductase A; Provisional; Region: PRK14054 220668004590 methionine sulfoxide reductase B; Provisional; Region: PRK00222 220668004591 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 220668004592 DHH family; Region: DHH; pfam01368 220668004593 DHHA2 domain; Region: DHHA2; pfam02833 220668004594 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668004595 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668004596 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 220668004597 dimerization interface [polypeptide binding]; other site 220668004598 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 220668004599 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 220668004600 CAP-like domain; other site 220668004601 active site 220668004602 primary dimer interface [polypeptide binding]; other site 220668004603 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 220668004604 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 220668004605 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 220668004606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 220668004607 ATP binding site [chemical binding]; other site 220668004608 Mg2+ binding site [ion binding]; other site 220668004609 G-X-G motif; other site 220668004610 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 220668004611 anchoring element; other site 220668004612 dimer interface [polypeptide binding]; other site 220668004613 ATP binding site [chemical binding]; other site 220668004614 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 220668004615 active site 220668004616 metal binding site [ion binding]; metal-binding site 220668004617 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 220668004618 membrane protein; Provisional; Region: PRK14392 220668004619 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 220668004620 active site 220668004621 catalytic residues [active] 220668004622 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 220668004623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668004624 Walker A motif; other site 220668004625 ATP binding site [chemical binding]; other site 220668004626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668004627 Walker B motif; other site 220668004628 arginine finger; other site 220668004629 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 220668004630 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 220668004631 active site 220668004632 HslU subunit interaction site [polypeptide binding]; other site 220668004633 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 220668004634 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 220668004635 active site 220668004636 DNA binding site [nucleotide binding] 220668004637 Int/Topo IB signature motif; other site 220668004638 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 220668004639 Glucose inhibited division protein A; Region: GIDA; pfam01134 220668004640 DNA topoisomerase I; Validated; Region: PRK05582 220668004641 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 220668004642 active site 220668004643 interdomain interaction site; other site 220668004644 putative metal-binding site [ion binding]; other site 220668004645 nucleotide binding site [chemical binding]; other site 220668004646 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 220668004647 domain I; other site 220668004648 DNA binding groove [nucleotide binding] 220668004649 phosphate binding site [ion binding]; other site 220668004650 domain II; other site 220668004651 domain III; other site 220668004652 nucleotide binding site [chemical binding]; other site 220668004653 catalytic site [active] 220668004654 domain IV; other site 220668004655 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 220668004656 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 220668004657 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 220668004658 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 220668004659 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 220668004660 RNA/DNA hybrid binding site [nucleotide binding]; other site 220668004661 active site 220668004662 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 220668004663 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 220668004664 GTP/Mg2+ binding site [chemical binding]; other site 220668004665 G4 box; other site 220668004666 G5 box; other site 220668004667 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 220668004668 G1 box; other site 220668004669 G1 box; other site 220668004670 GTP/Mg2+ binding site [chemical binding]; other site 220668004671 Switch I region; other site 220668004672 G2 box; other site 220668004673 G2 box; other site 220668004674 G3 box; other site 220668004675 G3 box; other site 220668004676 Switch II region; other site 220668004677 Switch II region; other site 220668004678 G4 box; other site 220668004679 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 220668004680 substrate binding site [chemical binding]; other site 220668004681 THF binding site; other site 220668004682 zinc-binding site [ion binding]; other site 220668004683 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668004684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668004685 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 220668004686 dimerization interface [polypeptide binding]; other site 220668004687 Mrr N-terminal domain; Region: Mrr_N; pfam14338 220668004688 Restriction endonuclease; Region: Mrr_cat; pfam04471 220668004689 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 220668004690 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 220668004691 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 220668004692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668004693 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668004694 putative substrate translocation pore; other site 220668004695 HemX; Region: HemX; cl19375 220668004696 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 220668004697 C-terminal peptidase (prc); Region: prc; TIGR00225 220668004698 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 220668004699 protein binding site [polypeptide binding]; other site 220668004700 Catalytic dyad [active] 220668004701 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 220668004702 hypothetical protein; Provisional; Region: PRK13672 220668004703 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 220668004704 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 220668004705 active site 220668004706 catalytic triad [active] 220668004707 oxyanion hole [active] 220668004708 EDD domain protein, DegV family; Region: DegV; TIGR00762 220668004709 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 220668004710 folate binding site [chemical binding]; other site 220668004711 NADP+ binding site [chemical binding]; other site 220668004712 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 220668004713 dimerization interface [polypeptide binding]; other site 220668004714 active site 220668004715 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 220668004716 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 220668004717 ABC transporter; Region: ABC_tran_2; pfam12848 220668004718 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 220668004719 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 220668004720 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 220668004721 active site 220668004722 NTP binding site [chemical binding]; other site 220668004723 metal binding triad [ion binding]; metal-binding site 220668004724 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 220668004725 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 220668004726 dihydrodipicolinate reductase; Provisional; Region: PRK00048 220668004727 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 220668004728 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 220668004729 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 220668004730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668004731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 220668004732 binding surface 220668004733 TPR motif; other site 220668004734 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 220668004735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 220668004736 binding surface 220668004737 TPR motif; other site 220668004738 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 220668004739 binding surface 220668004740 TPR motif; other site 220668004741 histone-like DNA-binding protein HU; Region: HU; cd13831 220668004742 dimer interface [polypeptide binding]; other site 220668004743 DNA binding site [nucleotide binding] 220668004744 GTP-binding protein Der; Reviewed; Region: PRK00093 220668004745 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 220668004746 G1 box; other site 220668004747 GTP/Mg2+ binding site [chemical binding]; other site 220668004748 Switch I region; other site 220668004749 G2 box; other site 220668004750 Switch II region; other site 220668004751 G3 box; other site 220668004752 G4 box; other site 220668004753 G5 box; other site 220668004754 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 220668004755 G1 box; other site 220668004756 GTP/Mg2+ binding site [chemical binding]; other site 220668004757 Switch I region; other site 220668004758 G2 box; other site 220668004759 G3 box; other site 220668004760 Switch II region; other site 220668004761 G4 box; other site 220668004762 G5 box; other site 220668004763 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 220668004764 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 220668004765 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 220668004766 RNA binding site [nucleotide binding]; other site 220668004767 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 220668004768 RNA binding site [nucleotide binding]; other site 220668004769 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 220668004770 RNA binding site [nucleotide binding]; other site 220668004771 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 220668004772 RNA binding site [nucleotide binding]; other site 220668004773 cytidylate kinase; Provisional; Region: cmk; PRK00023 220668004774 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 220668004775 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 220668004776 active site 220668004777 CMP-binding site; other site 220668004778 The sites determining sugar specificity; other site 220668004779 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 220668004780 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 220668004781 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 220668004782 ATP binding site [chemical binding]; other site 220668004783 putative Mg++ binding site [ion binding]; other site 220668004784 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 220668004785 nucleotide binding region [chemical binding]; other site 220668004786 ATP-binding site [chemical binding]; other site 220668004787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 220668004788 Helix-turn-helix domain; Region: HTH_40; pfam14493 220668004789 Predicted membrane protein [Function unknown]; Region: COG3601 220668004790 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 220668004791 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 220668004792 RNA binding surface [nucleotide binding]; other site 220668004793 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 220668004794 active site 220668004795 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 220668004796 ScpA/B protein; Region: ScpA_ScpB; cl00598 220668004797 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 220668004798 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 220668004799 active site 220668004800 Int/Topo IB signature motif; other site 220668004801 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 220668004802 S1 domain; Region: S1_2; pfam13509 220668004803 Protein of unknown function (DUF441); Region: DUF441; pfam04284 220668004804 pyruvate kinase; Provisional; Region: PRK06354 220668004805 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 220668004806 domain interfaces; other site 220668004807 active site 220668004808 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 220668004809 6-phosphofructokinase; Provisional; Region: PRK03202 220668004810 active site 220668004811 ADP/pyrophosphate binding site [chemical binding]; other site 220668004812 dimerization interface [polypeptide binding]; other site 220668004813 allosteric effector site; other site 220668004814 fructose-1,6-bisphosphate binding site; other site 220668004815 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 220668004816 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 220668004817 active site 220668004818 PHP Thumb interface [polypeptide binding]; other site 220668004819 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 220668004820 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 220668004821 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 220668004822 generic binding surface I; other site 220668004823 generic binding surface II; other site 220668004824 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 220668004825 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 220668004826 Clp amino terminal domain; Region: Clp_N; pfam02861 220668004827 Clp amino terminal domain; Region: Clp_N; pfam02861 220668004828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668004829 Walker A motif; other site 220668004830 ATP binding site [chemical binding]; other site 220668004831 Walker B motif; other site 220668004832 arginine finger; other site 220668004833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668004834 Walker A motif; other site 220668004835 ATP binding site [chemical binding]; other site 220668004836 Walker B motif; other site 220668004837 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 220668004838 peptidase T-like protein; Region: PepT-like; TIGR01883 220668004839 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 220668004840 metal binding site [ion binding]; metal-binding site 220668004841 dimer interface [polypeptide binding]; other site 220668004842 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 220668004843 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 220668004844 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 220668004845 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 220668004846 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 220668004847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668004848 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 220668004849 Walker A/P-loop; other site 220668004850 ATP binding site [chemical binding]; other site 220668004851 Q-loop/lid; other site 220668004852 ABC transporter signature motif; other site 220668004853 Walker B; other site 220668004854 D-loop; other site 220668004855 H-loop/switch region; other site 220668004856 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 220668004857 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668004858 phosphoenolpyruvate synthase; Validated; Region: PRK06464 220668004859 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 220668004860 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; cl17700 220668004861 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 220668004862 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 220668004863 active site residue [active] 220668004864 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668004865 MarR family; Region: MarR_2; cl17246 220668004866 Acyltransferase family; Region: Acyl_transf_3; cl19154 220668004867 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 220668004868 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 220668004869 putative NAD(P) binding site [chemical binding]; other site 220668004870 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 220668004871 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 220668004872 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 220668004873 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 220668004874 enolase; Provisional; Region: eno; PRK00077 220668004875 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 220668004876 dimer interface [polypeptide binding]; other site 220668004877 metal binding site [ion binding]; metal-binding site 220668004878 substrate binding pocket [chemical binding]; other site 220668004879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668004880 putative substrate translocation pore; other site 220668004881 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668004882 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668004883 MarR family; Region: MarR_2; pfam12802 220668004884 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 220668004885 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 220668004886 metal binding site [ion binding]; metal-binding site 220668004887 dimer interface [polypeptide binding]; other site 220668004888 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 220668004889 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 220668004890 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 220668004891 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 220668004892 active site residue [active] 220668004893 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 220668004894 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 220668004895 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 220668004896 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 220668004897 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 220668004898 nudix motif; other site 220668004899 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 220668004900 putative catalytic residues [active] 220668004901 thiol/disulfide switch; other site 220668004902 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 220668004903 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 220668004904 putative NAD(P) binding site [chemical binding]; other site 220668004905 Uncharacterized conserved protein [Function unknown]; Region: COG4715 220668004906 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 220668004907 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 220668004908 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668004909 motif II; other site 220668004910 maltose O-acetyltransferase; Provisional; Region: PRK10092 220668004911 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 220668004912 active site 220668004913 substrate binding site [chemical binding]; other site 220668004914 trimer interface [polypeptide binding]; other site 220668004915 CoA binding site [chemical binding]; other site 220668004916 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 220668004917 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 220668004918 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 220668004919 putative active site [active] 220668004920 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 220668004921 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668004922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 220668004923 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 220668004924 NAD(P) binding site [chemical binding]; other site 220668004925 active site 220668004926 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012 220668004927 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668004928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668004929 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 220668004930 dimerization interface [polypeptide binding]; other site 220668004931 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 220668004932 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 220668004933 putative NAD(P) binding site [chemical binding]; other site 220668004934 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 220668004935 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 220668004936 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 220668004937 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 220668004938 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 220668004939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 220668004940 active site 220668004941 phosphorylation site [posttranslational modification] 220668004942 intermolecular recognition site; other site 220668004943 dimerization interface [polypeptide binding]; other site 220668004944 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 220668004945 DNA binding residues [nucleotide binding] 220668004946 dimerization interface [polypeptide binding]; other site 220668004947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 220668004948 Histidine kinase; Region: HisKA_3; pfam07730 220668004949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 220668004950 ATP binding site [chemical binding]; other site 220668004951 Mg2+ binding site [ion binding]; other site 220668004952 G-X-G motif; other site 220668004953 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 220668004954 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 220668004955 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 220668004956 Walker A/P-loop; other site 220668004957 ATP binding site [chemical binding]; other site 220668004958 Q-loop/lid; other site 220668004959 ABC transporter signature motif; other site 220668004960 Walker B; other site 220668004961 D-loop; other site 220668004962 H-loop/switch region; other site 220668004963 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 220668004964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668004965 Coenzyme A binding pocket [chemical binding]; other site 220668004966 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 220668004967 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668004968 Predicted membrane protein [Function unknown]; Region: COG2364 220668004969 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 220668004970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668004971 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 220668004972 Walker A/P-loop; other site 220668004973 ATP binding site [chemical binding]; other site 220668004974 Q-loop/lid; other site 220668004975 ABC transporter signature motif; other site 220668004976 Walker B; other site 220668004977 D-loop; other site 220668004978 H-loop/switch region; other site 220668004979 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 220668004980 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 220668004981 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 220668004982 Walker A/P-loop; other site 220668004983 ATP binding site [chemical binding]; other site 220668004984 Q-loop/lid; other site 220668004985 ABC transporter signature motif; other site 220668004986 Walker B; other site 220668004987 D-loop; other site 220668004988 H-loop/switch region; other site 220668004989 Predicted transcriptional regulators [Transcription]; Region: COG1725 220668004990 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668004991 DNA-binding site [nucleotide binding]; DNA binding site 220668004992 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 220668004993 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 220668004994 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 220668004995 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 220668004996 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 220668004997 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 220668004998 DNA binding residues [nucleotide binding] 220668004999 DNA primase; Validated; Region: dnaG; PRK05667 220668005000 CHC2 zinc finger; Region: zf-CHC2; pfam01807 220668005001 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 220668005002 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 220668005003 active site 220668005004 metal binding site [ion binding]; metal-binding site 220668005005 interdomain interaction site; other site 220668005006 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 220668005007 PE-PPE domain; Region: PE-PPE; pfam08237 220668005008 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 220668005009 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 220668005010 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 220668005011 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 220668005012 dimer interface [polypeptide binding]; other site 220668005013 motif 1; other site 220668005014 active site 220668005015 motif 2; other site 220668005016 motif 3; other site 220668005017 DNA repair protein RecO; Region: reco; TIGR00613 220668005018 Recombination protein O N terminal; Region: RecO_N; pfam11967 220668005019 Recombination protein O C terminal; Region: RecO_C; pfam02565 220668005020 GTPase Era; Reviewed; Region: era; PRK00089 220668005021 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 220668005022 G1 box; other site 220668005023 GTP/Mg2+ binding site [chemical binding]; other site 220668005024 Switch I region; other site 220668005025 G2 box; other site 220668005026 Switch II region; other site 220668005027 G3 box; other site 220668005028 G4 box; other site 220668005029 G5 box; other site 220668005030 KH domain; Region: KH_2; pfam07650 220668005031 G-X-X-G motif; other site 220668005032 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 220668005033 trimer interface [polypeptide binding]; other site 220668005034 putative active site [active] 220668005035 Zn binding site [ion binding]; other site 220668005036 metal-binding heat shock protein; Provisional; Region: PRK00016 220668005037 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 220668005038 PhoH-like protein; Region: PhoH; pfam02562 220668005039 Yqey-like protein; Region: YqeY; pfam09424 220668005040 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 220668005041 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 220668005042 short chain dehydrogenase; Provisional; Region: PRK07041 220668005043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 220668005044 NAD(P) binding site [chemical binding]; other site 220668005045 active site 220668005046 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 220668005047 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 220668005048 AP (apurinic/apyrimidinic) site pocket; other site 220668005049 DNA interaction; other site 220668005050 Metal-binding active site; metal-binding site 220668005051 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 220668005052 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 220668005053 Uncharacterized conserved protein [Function unknown]; Region: COG1284 220668005054 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 220668005055 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 220668005056 methionine sulfoxide reductase A; Provisional; Region: PRK14054 220668005057 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 220668005058 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 220668005059 dimer interface [polypeptide binding]; other site 220668005060 anticodon binding site; other site 220668005061 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 220668005062 homodimer interface [polypeptide binding]; other site 220668005063 motif 1; other site 220668005064 active site 220668005065 motif 2; other site 220668005066 GAD domain; Region: GAD; pfam02938 220668005067 motif 3; other site 220668005068 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 220668005069 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 220668005070 dimer interface [polypeptide binding]; other site 220668005071 motif 1; other site 220668005072 active site 220668005073 motif 2; other site 220668005074 motif 3; other site 220668005075 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 220668005076 anticodon binding site; other site 220668005077 Bacterial SH3 domain homologues; Region: SH3b; smart00287 220668005078 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 220668005079 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 220668005080 active site 220668005081 metal binding site [ion binding]; metal-binding site 220668005082 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 220668005083 Phosphotransferase enzyme family; Region: APH; pfam01636 220668005084 active site 220668005085 substrate binding site [chemical binding]; other site 220668005086 ATP binding site [chemical binding]; other site 220668005087 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 220668005088 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 220668005089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668005090 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 220668005091 putative active site [active] 220668005092 dimerization interface [polypeptide binding]; other site 220668005093 putative tRNAtyr binding site [nucleotide binding]; other site 220668005094 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 220668005095 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 220668005096 Zn2+ binding site [ion binding]; other site 220668005097 Mg2+ binding site [ion binding]; other site 220668005098 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 220668005099 synthetase active site [active] 220668005100 NTP binding site [chemical binding]; other site 220668005101 metal binding site [ion binding]; metal-binding site 220668005102 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 220668005103 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 220668005104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 220668005105 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 220668005106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 220668005107 S-adenosylmethionine binding site [chemical binding]; other site 220668005108 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 220668005109 active site 220668005110 DNA binding site [nucleotide binding] 220668005111 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 220668005112 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668005113 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668005114 non-specific DNA binding site [nucleotide binding]; other site 220668005115 salt bridge; other site 220668005116 sequence-specific DNA binding site [nucleotide binding]; other site 220668005117 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 220668005118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 220668005119 Transposase; Region: DDE_Tnp_ISL3; pfam01610 220668005120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 220668005121 Src homology 2 (SH2) domain; Region: SH2; cl15255 220668005122 phosphotyrosine binding pocket [polypeptide binding]; other site 220668005123 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 220668005124 hydrophobic binding pocket [polypeptide binding]; other site 220668005125 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 220668005126 Helix-turn-helix domain; Region: HTH_28; pfam13518 220668005127 putative transposase OrfB; Reviewed; Region: PHA02517 220668005128 Integrase core domain; Region: rve; pfam00665 220668005129 Integrase core domain; Region: rve_3; cl15866 220668005130 GTP-binding protein LepA; Provisional; Region: PRK05433 220668005131 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 220668005132 G1 box; other site 220668005133 putative GEF interaction site [polypeptide binding]; other site 220668005134 GTP/Mg2+ binding site [chemical binding]; other site 220668005135 Switch I region; other site 220668005136 G2 box; other site 220668005137 G3 box; other site 220668005138 Switch II region; other site 220668005139 G4 box; other site 220668005140 G5 box; other site 220668005141 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 220668005142 Elongation Factor G, domain II; Region: EFG_II; pfam14492 220668005143 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 220668005144 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 220668005145 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 220668005146 DltD N-terminal region; Region: DltD_N; pfam04915 220668005147 DltD central region; Region: DltD_M; pfam04918 220668005148 DltD C-terminal region; Region: DltD_C; pfam04914 220668005149 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 220668005150 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 220668005151 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 220668005152 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 220668005153 acyl-activating enzyme (AAE) consensus motif; other site 220668005154 AMP binding site [chemical binding]; other site 220668005155 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 220668005156 Beta-lactamase; Region: Beta-lactamase; pfam00144 220668005157 chaperone protein DnaJ; Provisional; Region: PRK14276 220668005158 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 220668005159 HSP70 interaction site [polypeptide binding]; other site 220668005160 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 220668005161 substrate binding site [polypeptide binding]; other site 220668005162 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 220668005163 Zn binding sites [ion binding]; other site 220668005164 dimer interface [polypeptide binding]; other site 220668005165 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 220668005166 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 220668005167 nucleotide binding site [chemical binding]; other site 220668005168 NEF interaction site [polypeptide binding]; other site 220668005169 SBD interface [polypeptide binding]; other site 220668005170 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 220668005171 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 220668005172 dimer interface [polypeptide binding]; other site 220668005173 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 220668005174 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 220668005175 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 220668005176 HrcA protein C terminal domain; Region: HrcA; pfam01628 220668005177 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 220668005178 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 220668005179 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 220668005180 active site 220668005181 Riboflavin kinase; Region: Flavokinase; smart00904 220668005182 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 220668005183 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 220668005184 RNA binding site [nucleotide binding]; other site 220668005185 active site 220668005186 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 220668005187 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 220668005188 ADP binding site [chemical binding]; other site 220668005189 magnesium binding site [ion binding]; other site 220668005190 putative shikimate binding site; other site 220668005191 prephenate dehydrogenase; Validated; Region: PRK06545 220668005192 prephenate dehydrogenase; Validated; Region: PRK08507 220668005193 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 220668005194 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 220668005195 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 220668005196 hinge; other site 220668005197 active site 220668005198 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 220668005199 Tetramer interface [polypeptide binding]; other site 220668005200 active site 220668005201 FMN-binding site [chemical binding]; other site 220668005202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668005203 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668005204 putative substrate translocation pore; other site 220668005205 Chorismate mutase type II; Region: CM_2; smart00830 220668005206 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 220668005207 translation initiation factor IF-2; Validated; Region: infB; PRK05306 220668005208 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 220668005209 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 220668005210 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 220668005211 G1 box; other site 220668005212 putative GEF interaction site [polypeptide binding]; other site 220668005213 GTP/Mg2+ binding site [chemical binding]; other site 220668005214 Switch I region; other site 220668005215 G2 box; other site 220668005216 G3 box; other site 220668005217 Switch II region; other site 220668005218 G4 box; other site 220668005219 G5 box; other site 220668005220 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 220668005221 Translation-initiation factor 2; Region: IF-2; pfam11987 220668005222 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 220668005223 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 220668005224 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 220668005225 putative RNA binding cleft [nucleotide binding]; other site 220668005226 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 220668005227 NusA N-terminal domain; Region: NusA_N; pfam08529 220668005228 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 220668005229 RNA binding site [nucleotide binding]; other site 220668005230 homodimer interface [polypeptide binding]; other site 220668005231 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 220668005232 G-X-X-G motif; other site 220668005233 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 220668005234 G-X-X-G motif; other site 220668005235 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 220668005236 putative oligomer interface [polypeptide binding]; other site 220668005237 putative RNA binding site [nucleotide binding]; other site 220668005238 DNA polymerase III PolC; Validated; Region: polC; PRK00448 220668005239 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 220668005240 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 220668005241 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 220668005242 generic binding surface II; other site 220668005243 generic binding surface I; other site 220668005244 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 220668005245 active site 220668005246 putative PHP Thumb interface [polypeptide binding]; other site 220668005247 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 220668005248 active site 220668005249 catalytic site [active] 220668005250 substrate binding site [chemical binding]; other site 220668005251 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 220668005252 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 220668005253 prolyl-tRNA synthetase; Provisional; Region: PRK09194 220668005254 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 220668005255 dimer interface [polypeptide binding]; other site 220668005256 motif 1; other site 220668005257 active site 220668005258 motif 2; other site 220668005259 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 220668005260 putative deacylase active site [active] 220668005261 motif 3; other site 220668005262 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 220668005263 anticodon binding site; other site 220668005264 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 220668005265 RIP metalloprotease RseP; Region: TIGR00054 220668005266 active site 220668005267 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 220668005268 putative substrate binding region [chemical binding]; other site 220668005269 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 220668005270 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 220668005271 active site 220668005272 dimer interface [polypeptide binding]; other site 220668005273 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 220668005274 hinge region; other site 220668005275 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 220668005276 putative nucleotide binding site [chemical binding]; other site 220668005277 uridine monophosphate binding site [chemical binding]; other site 220668005278 homohexameric interface [polypeptide binding]; other site 220668005279 elongation factor Ts; Provisional; Region: tsf; PRK09377 220668005280 UBA/TS-N domain; Region: UBA; pfam00627 220668005281 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 220668005282 rRNA interaction site [nucleotide binding]; other site 220668005283 S8 interaction site; other site 220668005284 putative laminin-1 binding site; other site 220668005285 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 220668005286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668005287 motif II; other site 220668005288 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 220668005289 D-lactate dehydrogenase; Validated; Region: PRK08605 220668005290 homodimer interface [polypeptide binding]; other site 220668005291 ligand binding site [chemical binding]; other site 220668005292 NAD binding site [chemical binding]; other site 220668005293 catalytic site [active] 220668005294 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 220668005295 GIY-YIG motif/motif A; other site 220668005296 putative active site [active] 220668005297 putative metal binding site [ion binding]; other site 220668005298 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 220668005299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 220668005300 S-adenosylmethionine binding site [chemical binding]; other site 220668005301 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 220668005302 putative acyl-acceptor binding pocket; other site 220668005303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 220668005304 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 220668005305 LexA repressor; Validated; Region: PRK00215 220668005306 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 220668005307 putative DNA binding site [nucleotide binding]; other site 220668005308 putative Zn2+ binding site [ion binding]; other site 220668005309 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 220668005310 Catalytic site [active] 220668005311 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 220668005312 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 220668005313 dimer interface [polypeptide binding]; other site 220668005314 active site 220668005315 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 220668005316 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 220668005317 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 220668005318 Ligand binding site; other site 220668005319 Putative Catalytic site; other site 220668005320 DXD motif; other site 220668005321 Helix-turn-helix domain; Region: HTH_28; pfam13518 220668005322 Transcriptional regulator [Transcription]; Region: LytR; COG1316 220668005323 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 220668005324 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 220668005325 Walker A/P-loop; other site 220668005326 ATP binding site [chemical binding]; other site 220668005327 Q-loop/lid; other site 220668005328 ABC transporter signature motif; other site 220668005329 Walker B; other site 220668005330 D-loop; other site 220668005331 H-loop/switch region; other site 220668005332 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 220668005333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668005334 dimer interface [polypeptide binding]; other site 220668005335 conserved gate region; other site 220668005336 putative PBP binding loops; other site 220668005337 ABC-ATPase subunit interface; other site 220668005338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668005339 dimer interface [polypeptide binding]; other site 220668005340 conserved gate region; other site 220668005341 putative PBP binding loops; other site 220668005342 ABC-ATPase subunit interface; other site 220668005343 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 220668005344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 220668005345 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 220668005346 hypothetical protein; Provisional; Region: PRK00967 220668005347 H+ Antiporter protein; Region: 2A0121; TIGR00900 220668005348 Helix-turn-helix domain; Region: HTH_20; pfam12840 220668005349 dimerization interface [polypeptide binding]; other site 220668005350 putative DNA binding site [nucleotide binding]; other site 220668005351 putative Zn2+ binding site [ion binding]; other site 220668005352 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 220668005353 active site 220668005354 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 220668005355 DHH family; Region: DHH; pfam01368 220668005356 DHHA1 domain; Region: DHHA1; pfam02272 220668005357 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 220668005358 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 220668005359 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 220668005360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 220668005361 NAD(P) binding site [chemical binding]; other site 220668005362 active site 220668005363 ribonuclease Z; Region: RNase_Z; TIGR02651 220668005364 GTPase CgtA; Reviewed; Region: obgE; PRK12297 220668005365 GTP1/OBG; Region: GTP1_OBG; pfam01018 220668005366 Obg GTPase; Region: Obg; cd01898 220668005367 G1 box; other site 220668005368 GTP/Mg2+ binding site [chemical binding]; other site 220668005369 Switch I region; other site 220668005370 G2 box; other site 220668005371 G3 box; other site 220668005372 Switch II region; other site 220668005373 G4 box; other site 220668005374 G5 box; other site 220668005375 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 220668005376 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 220668005377 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 220668005378 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 220668005379 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 220668005380 putative substrate binding site [chemical binding]; other site 220668005381 putative ATP binding site [chemical binding]; other site 220668005382 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 220668005383 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 220668005384 active site 220668005385 phosphorylation site [posttranslational modification] 220668005386 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 220668005387 active site 220668005388 P-loop; other site 220668005389 phosphorylation site [posttranslational modification] 220668005390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668005391 putative substrate translocation pore; other site 220668005392 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 220668005393 active site 220668005394 metal binding site [ion binding]; metal-binding site 220668005395 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 220668005396 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 220668005397 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 220668005398 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 220668005399 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 220668005400 active site 220668005401 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 220668005402 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 220668005403 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 220668005404 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 220668005405 putative ADP-binding pocket [chemical binding]; other site 220668005406 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 220668005407 Bacterial sugar transferase; Region: Bac_transf; pfam02397 220668005408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 220668005409 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 220668005410 NAD(P) binding site [chemical binding]; other site 220668005411 active site 220668005412 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 220668005413 PHP domain; Region: PHP; pfam02811 220668005414 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 220668005415 AAA domain; Region: AAA_31; pfam13614 220668005416 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 220668005417 Chain length determinant protein; Region: Wzz; pfam02706 220668005418 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 220668005419 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 220668005420 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 220668005421 GIY-YIG motif/motif A; other site 220668005422 active site 220668005423 catalytic site [active] 220668005424 putative DNA binding site [nucleotide binding]; other site 220668005425 metal binding site [ion binding]; metal-binding site 220668005426 UvrB/uvrC motif; Region: UVR; pfam02151 220668005427 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 220668005428 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 220668005429 DNA binding site [nucleotide binding] 220668005430 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 220668005431 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 220668005432 Walker A/P-loop; other site 220668005433 ATP binding site [chemical binding]; other site 220668005434 Q-loop/lid; other site 220668005435 ABC transporter signature motif; other site 220668005436 Walker B; other site 220668005437 D-loop; other site 220668005438 H-loop/switch region; other site 220668005439 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 220668005440 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 220668005441 substrate binding pocket [chemical binding]; other site 220668005442 membrane-bound complex binding site; other site 220668005443 hinge residues; other site 220668005444 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 220668005445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668005446 dimer interface [polypeptide binding]; other site 220668005447 conserved gate region; other site 220668005448 putative PBP binding loops; other site 220668005449 ABC-ATPase subunit interface; other site 220668005450 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; pfam01521 220668005451 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 220668005452 putative metal binding site [ion binding]; other site 220668005453 Predicted GTPase [General function prediction only]; Region: COG0218 220668005454 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 220668005455 G1 box; other site 220668005456 GTP/Mg2+ binding site [chemical binding]; other site 220668005457 Switch I region; other site 220668005458 G2 box; other site 220668005459 G3 box; other site 220668005460 Switch II region; other site 220668005461 G4 box; other site 220668005462 G5 box; other site 220668005463 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 220668005464 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 220668005465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668005466 Walker A motif; other site 220668005467 ATP binding site [chemical binding]; other site 220668005468 Walker B motif; other site 220668005469 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 220668005470 trigger factor; Provisional; Region: tig; PRK01490 220668005471 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 220668005472 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 220668005473 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 220668005474 elongation factor Tu; Reviewed; Region: PRK12736 220668005475 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 220668005476 G1 box; other site 220668005477 GEF interaction site [polypeptide binding]; other site 220668005478 GTP/Mg2+ binding site [chemical binding]; other site 220668005479 Switch I region; other site 220668005480 G2 box; other site 220668005481 G3 box; other site 220668005482 Switch II region; other site 220668005483 G4 box; other site 220668005484 G5 box; other site 220668005485 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 220668005486 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 220668005487 Antibiotic Binding Site [chemical binding]; other site 220668005488 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 220668005489 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 220668005490 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 220668005491 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 220668005492 dimer interface [polypeptide binding]; other site 220668005493 active site 220668005494 catalytic residue [active] 220668005495 drug efflux system protein MdtG; Provisional; Region: PRK09874 220668005496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668005497 putative substrate translocation pore; other site 220668005498 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 220668005499 16S/18S rRNA binding site [nucleotide binding]; other site 220668005500 S13e-L30e interaction site [polypeptide binding]; other site 220668005501 25S rRNA binding site [nucleotide binding]; other site 220668005502 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 220668005503 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 220668005504 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 220668005505 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 220668005506 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 220668005507 Competence protein; Region: Competence; pfam03772 220668005508 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 220668005509 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 220668005510 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 220668005511 catalytic motif [active] 220668005512 Zn binding site [ion binding]; other site 220668005513 Fungal domain of unknown function (DUF1750); Region: SWI-SNF_Ssr4; pfam08549 220668005514 SLBB domain; Region: SLBB; pfam10531 220668005515 comEA protein; Region: comE; TIGR01259 220668005516 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 220668005517 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 220668005518 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 220668005519 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 220668005520 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 220668005521 active site 220668005522 (T/H)XGH motif; other site 220668005523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 220668005524 S-adenosylmethionine binding site [chemical binding]; other site 220668005525 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 220668005526 pyruvate carboxylase; Reviewed; Region: PRK12999 220668005527 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 220668005528 ATP-grasp domain; Region: ATP-grasp_4; cl17255 220668005529 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 220668005530 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 220668005531 active site 220668005532 catalytic residues [active] 220668005533 metal binding site [ion binding]; metal-binding site 220668005534 homodimer binding site [polypeptide binding]; other site 220668005535 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 220668005536 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 220668005537 carboxyltransferase (CT) interaction site; other site 220668005538 biotinylation site [posttranslational modification]; other site 220668005539 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 220668005540 conserved hypothetical integral membrane protein; Region: TIGR03766 220668005541 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 220668005542 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 220668005543 DXD motif; other site 220668005544 exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110 220668005545 Firmicu-CTERM domain; Region: Firmicu_CTERM; TIGR04145 220668005546 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 220668005547 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 220668005548 G1 box; other site 220668005549 putative GEF interaction site [polypeptide binding]; other site 220668005550 GTP/Mg2+ binding site [chemical binding]; other site 220668005551 Switch I region; other site 220668005552 G2 box; other site 220668005553 G3 box; other site 220668005554 Switch II region; other site 220668005555 G4 box; other site 220668005556 G5 box; other site 220668005557 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 220668005558 Elongation Factor G, domain II; Region: EFG_II; pfam14492 220668005559 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 220668005560 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 220668005561 active site 220668005562 hypothetical protein; Provisional; Region: PRK04387 220668005563 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 220668005564 substrate binding site [chemical binding]; other site 220668005565 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 220668005566 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668005567 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 220668005568 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 220668005569 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 220668005570 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 220668005571 E3 interaction surface; other site 220668005572 lipoyl attachment site [posttranslational modification]; other site 220668005573 e3 binding domain; Region: E3_binding; pfam02817 220668005574 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 220668005575 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 220668005576 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 220668005577 alpha subunit interface [polypeptide binding]; other site 220668005578 TPP binding site [chemical binding]; other site 220668005579 heterodimer interface [polypeptide binding]; other site 220668005580 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 220668005581 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 220668005582 TPP-binding site [chemical binding]; other site 220668005583 heterodimer interface [polypeptide binding]; other site 220668005584 tetramer interface [polypeptide binding]; other site 220668005585 phosphorylation loop region [posttranslational modification] 220668005586 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 220668005587 active site 220668005588 catalytic residues [active] 220668005589 metal binding site [ion binding]; metal-binding site 220668005590 hypothetical protein; Provisional; Region: PRK13667 220668005591 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 220668005592 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 220668005593 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 220668005594 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 220668005595 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 220668005596 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 220668005597 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 220668005598 NlpC/P60 family; Region: NLPC_P60; pfam00877 220668005599 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 220668005600 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 220668005601 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 220668005602 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 220668005603 Transposase; Region: DDE_Tnp_ISL3; pfam01610 220668005604 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 220668005605 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 220668005606 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 220668005607 active site 220668005608 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 220668005609 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 220668005610 AAA domain; Region: AAA_30; pfam13604 220668005611 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 220668005612 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 220668005613 binding surface 220668005614 TPR motif; other site 220668005615 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 220668005616 catalytic core [active] 220668005617 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668005618 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 220668005619 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 220668005620 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668005621 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 220668005622 TrkA-N domain; Region: TrkA_N; pfam02254 220668005623 TrkA-C domain; Region: TrkA_C; pfam02080 220668005624 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 220668005625 Cation transport protein; Region: TrkH; cl17365 220668005626 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 220668005627 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 220668005628 Ligand Binding Site [chemical binding]; other site 220668005629 Putative amino acid metabolizm; Region: DUF1831; pfam08866 220668005630 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 220668005631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 220668005632 catalytic residue [active] 220668005633 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 220668005634 TIGR03503 family protein; Region: TIGR03503 220668005635 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 220668005636 dimer interface [polypeptide binding]; other site 220668005637 ADP-ribose binding site [chemical binding]; other site 220668005638 active site 220668005639 nudix motif; other site 220668005640 metal binding site [ion binding]; metal-binding site 220668005641 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 220668005642 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 220668005643 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 220668005644 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 220668005645 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 220668005646 active site 220668005647 HIGH motif; other site 220668005648 KMSKS motif; other site 220668005649 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 220668005650 tRNA binding surface [nucleotide binding]; other site 220668005651 anticodon binding site; other site 220668005652 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 220668005653 DivIVA protein; Region: DivIVA; pfam05103 220668005654 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 220668005655 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 220668005656 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 220668005657 YGGT family; Region: YGGT; pfam02325 220668005658 Protein of unknown function (DUF552); Region: DUF552; cl00775 220668005659 cell division protein FtsZ; Validated; Region: PRK09330 220668005660 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 220668005661 nucleotide binding site [chemical binding]; other site 220668005662 SulA interaction site; other site 220668005663 cell division protein FtsA; Region: ftsA; TIGR01174 220668005664 Cell division protein FtsA; Region: FtsA; smart00842 220668005665 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 220668005666 nucleotide binding site [chemical binding]; other site 220668005667 Cell division protein FtsA; Region: FtsA; pfam14450 220668005668 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 220668005669 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 220668005670 Cell division protein FtsQ; Region: FtsQ; pfam03799 220668005671 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 220668005672 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 220668005673 active site 220668005674 homodimer interface [polypeptide binding]; other site 220668005675 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 220668005676 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 220668005677 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 220668005678 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 220668005679 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 220668005680 Mg++ binding site [ion binding]; other site 220668005681 putative catalytic motif [active] 220668005682 putative substrate binding site [chemical binding]; other site 220668005683 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 220668005684 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 220668005685 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 220668005686 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 220668005687 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 220668005688 cell division protein FtsL; Region: ftsL_broad; TIGR02209 220668005689 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 220668005690 cell division protein MraZ; Reviewed; Region: PRK00326 220668005691 MraZ protein; Region: MraZ; pfam02381 220668005692 MraZ protein; Region: MraZ; pfam02381 220668005693 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 220668005694 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 220668005695 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 220668005696 Cl binding site [ion binding]; other site 220668005697 oligomer interface [polypeptide binding]; other site 220668005698 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 220668005699 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 220668005700 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 220668005701 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 220668005702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 220668005703 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 220668005704 NAD(P) binding site [chemical binding]; other site 220668005705 active site 220668005706 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 220668005707 Methyltransferase domain; Region: Methyltransf_31; pfam13847 220668005708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 220668005709 S-adenosylmethionine binding site [chemical binding]; other site 220668005710 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 220668005711 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 220668005712 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 220668005713 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 220668005714 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 220668005715 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 220668005716 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 220668005717 active site 220668005718 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 220668005719 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 220668005720 synthetase active site [active] 220668005721 NTP binding site [chemical binding]; other site 220668005722 metal binding site [ion binding]; metal-binding site 220668005723 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 220668005724 catalytic residues [active] 220668005725 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 220668005726 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 220668005727 active site 220668005728 Zn binding site [ion binding]; other site 220668005729 Competence protein CoiA-like family; Region: CoiA; cl11541 220668005730 adaptor protein; Provisional; Region: PRK02315 220668005731 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 220668005732 putative catalytic residues [active] 220668005733 thiol/disulfide switch; other site 220668005734 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 220668005735 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 220668005736 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 220668005737 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 220668005738 RNA binding site [nucleotide binding]; other site 220668005739 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 220668005740 active site 220668005741 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 220668005742 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 220668005743 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 220668005744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668005745 active site 220668005746 motif I; other site 220668005747 motif II; other site 220668005748 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 220668005749 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 220668005750 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 220668005751 active site 220668005752 metal binding site [ion binding]; metal-binding site 220668005753 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 220668005754 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 220668005755 putative active site [active] 220668005756 putative metal binding site [ion binding]; other site 220668005757 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 220668005758 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 220668005759 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 220668005760 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 220668005761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 220668005762 S-adenosylmethionine binding site [chemical binding]; other site 220668005763 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 220668005764 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 220668005765 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 220668005766 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 220668005767 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 220668005768 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 220668005769 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 220668005770 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 220668005771 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 220668005772 Walker A motif; other site 220668005773 ATP binding site [chemical binding]; other site 220668005774 Walker B motif; other site 220668005775 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 220668005776 substrate binding site [chemical binding]; other site 220668005777 dimer interface [polypeptide binding]; other site 220668005778 ATP binding site [chemical binding]; other site 220668005779 hypothetical protein; Validated; Region: PRK00110 220668005780 DsrE/DsrF-like family; Region: DrsE; cl00672 220668005781 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 220668005782 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 220668005783 catabolite control protein A; Region: ccpA; TIGR01481 220668005784 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 220668005785 DNA binding site [nucleotide binding] 220668005786 domain linker motif; other site 220668005787 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 220668005788 dimerization interface [polypeptide binding]; other site 220668005789 effector binding site; other site 220668005790 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 220668005791 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 220668005792 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 220668005793 active site 220668005794 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 220668005795 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 220668005796 DNA binding residues [nucleotide binding] 220668005797 putative dimer interface [polypeptide binding]; other site 220668005798 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 220668005799 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 220668005800 Mechanosensitive ion channel; Region: MS_channel; pfam00924 220668005801 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 220668005802 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 220668005803 metal binding site [ion binding]; metal-binding site 220668005804 putative dimer interface [polypeptide binding]; other site 220668005805 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 220668005806 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 220668005807 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 220668005808 trimer interface [polypeptide binding]; other site 220668005809 active site 220668005810 substrate binding site [chemical binding]; other site 220668005811 CoA binding site [chemical binding]; other site 220668005812 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 220668005813 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 220668005814 active site 220668005815 metal binding site [ion binding]; metal-binding site 220668005816 homotetramer interface [polypeptide binding]; other site 220668005817 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 220668005818 active site 220668005819 dimerization interface [polypeptide binding]; other site 220668005820 glutamate racemase; Provisional; Region: PRK00865 220668005821 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 220668005822 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 220668005823 catalytic residues [active] 220668005824 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 220668005825 MutS domain III; Region: MutS_III; pfam05192 220668005826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668005827 Walker A/P-loop; other site 220668005828 ATP binding site [chemical binding]; other site 220668005829 Q-loop/lid; other site 220668005830 ABC transporter signature motif; other site 220668005831 Walker B; other site 220668005832 D-loop; other site 220668005833 H-loop/switch region; other site 220668005834 Smr domain; Region: Smr; pfam01713 220668005835 Cell division protein ZapA; Region: ZapA; cl01146 220668005836 hypothetical protein; Provisional; Region: PRK13678 220668005837 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 220668005838 hypothetical protein; Provisional; Region: PRK05473 220668005839 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 220668005840 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 220668005841 motif 1; other site 220668005842 active site 220668005843 motif 2; other site 220668005844 motif 3; other site 220668005845 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 220668005846 DHHA1 domain; Region: DHHA1; pfam02272 220668005847 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 220668005848 DEAD-like helicases superfamily; Region: DEXDc; smart00487 220668005849 ATP binding site [chemical binding]; other site 220668005850 Mg++ binding site [ion binding]; other site 220668005851 motif III; other site 220668005852 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 220668005853 nucleotide binding region [chemical binding]; other site 220668005854 ATP-binding site [chemical binding]; other site 220668005855 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 220668005856 DHH family; Region: DHH; pfam01368 220668005857 DHHA1 domain; Region: DHHA1; pfam02272 220668005858 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 220668005859 active site 220668005860 DNA polymerase IV; Validated; Region: PRK02406 220668005861 DNA binding site [nucleotide binding] 220668005862 Preprotein translocase subunit; Region: YajC; pfam02699 220668005863 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 220668005864 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 220668005865 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 220668005866 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 220668005867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668005868 Walker A motif; other site 220668005869 ATP binding site [chemical binding]; other site 220668005870 Walker B motif; other site 220668005871 arginine finger; other site 220668005872 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 220668005873 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 220668005874 RuvA N terminal domain; Region: RuvA_N; pfam01330 220668005875 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 220668005876 Protein of unknown function (DUF1015); Region: DUF1015; cl19858 220668005877 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 220668005878 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 220668005879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 220668005880 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 220668005881 ATP binding site [chemical binding]; other site 220668005882 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 220668005883 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 220668005884 MutS domain I; Region: MutS_I; pfam01624 220668005885 MutS domain II; Region: MutS_II; pfam05188 220668005886 MutS domain III; Region: MutS_III; pfam05192 220668005887 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 220668005888 Walker A/P-loop; other site 220668005889 ATP binding site [chemical binding]; other site 220668005890 Q-loop/lid; other site 220668005891 ABC transporter signature motif; other site 220668005892 Walker B; other site 220668005893 D-loop; other site 220668005894 H-loop/switch region; other site 220668005895 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 220668005896 putative active site [active] 220668005897 metal binding site [ion binding]; metal-binding site 220668005898 homodimer binding site [polypeptide binding]; other site 220668005899 ribonuclease Y; Region: RNase_Y; TIGR03319 220668005900 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 220668005901 KH domain; Region: KH_1; pfam00013 220668005902 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 220668005903 Zn2+ binding site [ion binding]; other site 220668005904 Mg2+ binding site [ion binding]; other site 220668005905 recombinase A; Provisional; Region: recA; PRK09354 220668005906 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 220668005907 hexamer interface [polypeptide binding]; other site 220668005908 Walker A motif; other site 220668005909 ATP binding site [chemical binding]; other site 220668005910 Walker B motif; other site 220668005911 competence damage-inducible protein A; Provisional; Region: PRK00549 220668005912 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 220668005913 putative MPT binding site; other site 220668005914 Competence-damaged protein; Region: CinA; pfam02464 220668005915 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 220668005916 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 220668005917 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668005918 non-specific DNA binding site [nucleotide binding]; other site 220668005919 salt bridge; other site 220668005920 sequence-specific DNA binding site [nucleotide binding]; other site 220668005921 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 220668005922 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 220668005923 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 220668005924 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 220668005925 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 220668005926 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 220668005927 aspartate kinase; Reviewed; Region: PRK09034 220668005928 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 220668005929 putative catalytic residues [active] 220668005930 putative nucleotide binding site [chemical binding]; other site 220668005931 putative aspartate binding site [chemical binding]; other site 220668005932 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 220668005933 allosteric regulatory residue; other site 220668005934 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 220668005935 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 220668005936 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 220668005937 substrate binding pocket [chemical binding]; other site 220668005938 membrane-bound complex binding site; other site 220668005939 hinge residues; other site 220668005940 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 220668005941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668005942 Walker A/P-loop; other site 220668005943 ATP binding site [chemical binding]; other site 220668005944 Q-loop/lid; other site 220668005945 ABC transporter signature motif; other site 220668005946 Walker B; other site 220668005947 D-loop; other site 220668005948 H-loop/switch region; other site 220668005949 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 220668005950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668005951 dimer interface [polypeptide binding]; other site 220668005952 conserved gate region; other site 220668005953 putative PBP binding loops; other site 220668005954 ABC-ATPase subunit interface; other site 220668005955 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 220668005956 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 220668005957 P-loop; other site 220668005958 ADP binding residues [chemical binding]; other site 220668005959 Switch I; other site 220668005960 Switch II; other site 220668005961 septum formation inhibitor; Reviewed; Region: minC; PRK00513 220668005962 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 220668005963 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 220668005964 rod shape-determining protein MreC; Provisional; Region: PRK13922 220668005965 rod shape-determining protein MreB; Provisional; Region: PRK13927 220668005966 MreB and similar proteins; Region: MreB_like; cd10225 220668005967 nucleotide binding site [chemical binding]; other site 220668005968 Mg binding site [ion binding]; other site 220668005969 putative protofilament interaction site [polypeptide binding]; other site 220668005970 RodZ interaction site [polypeptide binding]; other site 220668005971 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 220668005972 MPN+ (JAMM) motif; other site 220668005973 Zinc-binding site [ion binding]; other site 220668005974 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 220668005975 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 220668005976 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 220668005977 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 220668005978 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 220668005979 active site 220668005980 HIGH motif; other site 220668005981 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 220668005982 KMSKS motif; other site 220668005983 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 220668005984 tRNA binding surface [nucleotide binding]; other site 220668005985 anticodon binding site; other site 220668005986 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 220668005987 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 220668005988 dimer interface [polypeptide binding]; other site 220668005989 catalytic triad [active] 220668005990 peroxidatic and resolving cysteines [active] 220668005991 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 220668005992 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 220668005993 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 220668005994 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 220668005995 Ligand Binding Site [chemical binding]; other site 220668005996 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 220668005997 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 220668005998 catalytic residue [active] 220668005999 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 220668006000 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 220668006001 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 220668006002 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 220668006003 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 220668006004 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 220668006005 RNA binding surface [nucleotide binding]; other site 220668006006 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 220668006007 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 220668006008 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 220668006009 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 220668006010 dimerization interface [polypeptide binding]; other site 220668006011 putative DNA binding site [nucleotide binding]; other site 220668006012 putative Zn2+ binding site [ion binding]; other site 220668006013 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 220668006014 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 220668006015 ATP-grasp domain; Region: ATP-grasp_4; cl17255 220668006016 recombination factor protein RarA; Reviewed; Region: PRK13342 220668006017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668006018 Walker A motif; other site 220668006019 ATP binding site [chemical binding]; other site 220668006020 Walker B motif; other site 220668006021 arginine finger; other site 220668006022 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 220668006023 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 220668006024 Ligand Binding Site [chemical binding]; other site 220668006025 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 220668006026 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 220668006027 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 220668006028 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668006029 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668006030 non-specific DNA binding site [nucleotide binding]; other site 220668006031 salt bridge; other site 220668006032 sequence-specific DNA binding site [nucleotide binding]; other site 220668006033 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 220668006034 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 220668006035 putative active site [active] 220668006036 catalytic site [active] 220668006037 putative metal binding site [ion binding]; other site 220668006038 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 220668006039 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 220668006040 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 220668006041 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 220668006042 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 220668006043 putative NAD(P) binding site [chemical binding]; other site 220668006044 dimer interface [polypeptide binding]; other site 220668006045 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 220668006046 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 220668006047 tetramer (dimer of dimers) interface [polypeptide binding]; other site 220668006048 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 220668006049 NAD binding site [chemical binding]; other site 220668006050 dimer interface [polypeptide binding]; other site 220668006051 substrate binding site [chemical binding]; other site 220668006052 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 220668006053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668006054 dimer interface [polypeptide binding]; other site 220668006055 conserved gate region; other site 220668006056 ABC-ATPase subunit interface; other site 220668006057 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 220668006058 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 220668006059 Walker A/P-loop; other site 220668006060 ATP binding site [chemical binding]; other site 220668006061 Q-loop/lid; other site 220668006062 ABC transporter signature motif; other site 220668006063 Walker B; other site 220668006064 D-loop; other site 220668006065 H-loop/switch region; other site 220668006066 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 220668006067 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 220668006068 lipoyl attachment site [posttranslational modification]; other site 220668006069 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 220668006070 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 220668006071 hypothetical protein; Validated; Region: PRK00041 220668006072 rod shape-determining protein MreB; Provisional; Region: PRK13930 220668006073 MreB and similar proteins; Region: MreB_like; cd10225 220668006074 nucleotide binding site [chemical binding]; other site 220668006075 Mg binding site [ion binding]; other site 220668006076 putative protofilament interaction site [polypeptide binding]; other site 220668006077 RodZ interaction site [polypeptide binding]; other site 220668006078 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 220668006079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 220668006080 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 220668006081 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 220668006082 hinge; other site 220668006083 active site 220668006084 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 220668006085 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 220668006086 gamma subunit interface [polypeptide binding]; other site 220668006087 epsilon subunit interface [polypeptide binding]; other site 220668006088 LBP interface [polypeptide binding]; other site 220668006089 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 220668006090 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 220668006091 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 220668006092 alpha subunit interaction interface [polypeptide binding]; other site 220668006093 Walker A motif; other site 220668006094 ATP binding site [chemical binding]; other site 220668006095 Walker B motif; other site 220668006096 inhibitor binding site; inhibition site 220668006097 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 220668006098 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 220668006099 core domain interface [polypeptide binding]; other site 220668006100 delta subunit interface [polypeptide binding]; other site 220668006101 epsilon subunit interface [polypeptide binding]; other site 220668006102 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 220668006103 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 220668006104 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 220668006105 beta subunit interaction interface [polypeptide binding]; other site 220668006106 Walker A motif; other site 220668006107 ATP binding site [chemical binding]; other site 220668006108 Walker B motif; other site 220668006109 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 220668006110 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 220668006111 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 220668006112 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 220668006113 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 220668006114 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 220668006115 Sulfate transporter family; Region: Sulfate_transp; cl19250 220668006116 uracil-xanthine permease; Region: ncs2; TIGR00801 220668006117 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 220668006118 active site 220668006119 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 220668006120 dimer interface [polypeptide binding]; other site 220668006121 active site 220668006122 glycine-pyridoxal phosphate binding site [chemical binding]; other site 220668006123 folate binding site [chemical binding]; other site 220668006124 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 220668006125 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 220668006126 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 220668006127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 220668006128 S-adenosylmethionine binding site [chemical binding]; other site 220668006129 peptide chain release factor 1; Validated; Region: prfA; PRK00591 220668006130 This domain is found in peptide chain release factors; Region: PCRF; smart00937 220668006131 RF-1 domain; Region: RF-1; pfam00472 220668006132 thymidine kinase; Provisional; Region: PRK04296 220668006133 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 220668006134 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 220668006135 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 220668006136 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 220668006137 catalytic triad [active] 220668006138 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 220668006139 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 220668006140 Beta-lactamase; Region: Beta-lactamase; pfam00144 220668006141 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 220668006142 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 220668006143 homodimer interface [polypeptide binding]; other site 220668006144 substrate-cofactor binding pocket; other site 220668006145 catalytic residue [active] 220668006146 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 220668006147 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 220668006148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668006149 Walker A/P-loop; other site 220668006150 ATP binding site [chemical binding]; other site 220668006151 Q-loop/lid; other site 220668006152 ABC transporter signature motif; other site 220668006153 Walker B; other site 220668006154 D-loop; other site 220668006155 H-loop/switch region; other site 220668006156 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 220668006157 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 220668006158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668006159 Walker A/P-loop; other site 220668006160 ATP binding site [chemical binding]; other site 220668006161 Q-loop/lid; other site 220668006162 ABC transporter signature motif; other site 220668006163 Walker B; other site 220668006164 D-loop; other site 220668006165 H-loop/switch region; other site 220668006166 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 220668006167 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 220668006168 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 220668006169 putative active site [active] 220668006170 putative metal binding site [ion binding]; other site 220668006171 Bacteriophage holin; Region: Phage_holin_1; cl02344 220668006172 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 220668006173 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 220668006174 active site 220668006175 Bacterial SH3 domain; Region: SH3_5; pfam08460 220668006176 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 220668006177 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 220668006178 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 220668006179 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 220668006180 active site 220668006181 catalytic triad [active] 220668006182 oxyanion hole [active] 220668006183 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 220668006184 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 220668006185 Phage tail protein; Region: Sipho_tail; cl17486 220668006186 phiKZ-like phage internal head proteins; Region: phiKZ_IP; pfam12699 220668006187 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 220668006188 tape measure domain; Region: tape_meas_nterm; TIGR02675 220668006189 Phage-related protein [Function unknown]; Region: COG5412 220668006190 membrane protein P6; Region: PHA01399 220668006191 membrane protein P6; Region: PHA01399 220668006192 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 220668006193 catalytic residue [active] 220668006194 Phage protein; Region: DUF3647; pfam12363 220668006195 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; cl12124 220668006196 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 220668006197 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 220668006198 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 220668006199 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 220668006200 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 220668006201 Terminase small subunit; Region: Terminase_2; pfam03592 220668006202 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 220668006203 YopX protein; Region: YopX; pfam09643 220668006204 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 220668006205 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 220668006206 Protein of unknown function (DUF669); Region: DUF669; pfam05037 220668006207 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 220668006208 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 220668006209 Autophagy protein Apg6; Region: APG6; pfam04111 220668006210 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 220668006211 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668006212 sequence-specific DNA binding site [nucleotide binding]; other site 220668006213 salt bridge; other site 220668006214 Domain of unknown function (DUF771); Region: DUF771; cl09962 220668006215 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668006216 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668006217 non-specific DNA binding site [nucleotide binding]; other site 220668006218 salt bridge; other site 220668006219 sequence-specific DNA binding site [nucleotide binding]; other site 220668006220 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668006221 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668006222 non-specific DNA binding site [nucleotide binding]; other site 220668006223 salt bridge; other site 220668006224 sequence-specific DNA binding site [nucleotide binding]; other site 220668006225 Domain of unknown function (DUF955); Region: DUF955; pfam06114 220668006226 Uncharacterized conserved protein [Function unknown]; Region: COG4748 220668006227 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 220668006228 AAA ATPase domain; Region: AAA_15; pfam13175 220668006229 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668006230 Walker A/P-loop; other site 220668006231 ATP binding site [chemical binding]; other site 220668006232 AAA domain; Region: AAA_21; pfam13304 220668006233 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 220668006234 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 220668006235 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 220668006236 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 220668006237 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 220668006238 Int/Topo IB signature motif; other site 220668006239 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 220668006240 oligomerization interface [polypeptide binding]; other site 220668006241 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 220668006242 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 220668006243 Phage capsid family; Region: Phage_capsid; pfam05065 220668006244 Phage portal protein; Region: Phage_portal; cl19194 220668006245 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 220668006246 Phage Terminase; Region: Terminase_1; cl19862 220668006247 Phage terminase, small subunit; Region: Terminase_4; pfam05119 220668006248 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 220668006249 active site 220668006250 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 220668006251 Virulence-associated protein E; Region: VirE; pfam05272 220668006252 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 220668006253 polymerase nucleotide-binding site; other site 220668006254 DNA-binding residues [nucleotide binding]; DNA binding site 220668006255 nucleotide binding site [chemical binding]; other site 220668006256 primase nucleotide-binding site [nucleotide binding]; other site 220668006257 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 220668006258 Helix-turn-helix domain; Region: HTH_17; pfam12728 220668006259 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668006260 non-specific DNA binding site [nucleotide binding]; other site 220668006261 salt bridge; other site 220668006262 sequence-specific DNA binding site [nucleotide binding]; other site 220668006263 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 220668006264 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 220668006265 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 220668006266 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 220668006267 Int/Topo IB signature motif; other site 220668006268 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668006269 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 220668006270 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 220668006271 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 220668006272 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668006273 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668006274 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668006275 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668006276 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668006277 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 220668006278 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 220668006279 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 220668006280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668006281 Walker A/P-loop; other site 220668006282 ATP binding site [chemical binding]; other site 220668006283 Q-loop/lid; other site 220668006284 ABC transporter signature motif; other site 220668006285 Walker B; other site 220668006286 D-loop; other site 220668006287 H-loop/switch region; other site 220668006288 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 220668006289 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 220668006290 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 220668006291 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 220668006292 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 220668006293 Walker A/P-loop; other site 220668006294 ATP binding site [chemical binding]; other site 220668006295 Q-loop/lid; other site 220668006296 ABC transporter signature motif; other site 220668006297 Walker B; other site 220668006298 D-loop; other site 220668006299 H-loop/switch region; other site 220668006300 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 220668006301 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 220668006302 FtsX-like permease family; Region: FtsX; pfam02687 220668006303 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 220668006304 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 220668006305 active site 220668006306 dimer interface [polypeptide binding]; other site 220668006307 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 220668006308 dimer interface [polypeptide binding]; other site 220668006309 active site 220668006310 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 220668006311 Sugar transport protein; Region: Sugar_transport; pfam06800 220668006312 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 220668006313 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 220668006314 putative RNA binding site [nucleotide binding]; other site 220668006315 Peptidase family S64; Region: Peptidase_S64; pfam08192 220668006316 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 220668006317 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 220668006318 dimerization interface [polypeptide binding]; other site 220668006319 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 220668006320 dimer interface [polypeptide binding]; other site 220668006321 phosphorylation site [posttranslational modification] 220668006322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 220668006323 ATP binding site [chemical binding]; other site 220668006324 Mg2+ binding site [ion binding]; other site 220668006325 G-X-G motif; other site 220668006326 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 220668006327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 220668006328 active site 220668006329 phosphorylation site [posttranslational modification] 220668006330 intermolecular recognition site; other site 220668006331 dimerization interface [polypeptide binding]; other site 220668006332 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 220668006333 DNA binding site [nucleotide binding] 220668006334 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 220668006335 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 220668006336 EamA-like transporter family; Region: EamA; pfam00892 220668006337 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 220668006338 EamA-like transporter family; Region: EamA; pfam00892 220668006339 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 220668006340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668006341 benzoate transport; Region: 2A0115; TIGR00895 220668006342 putative substrate translocation pore; other site 220668006343 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 220668006344 nudix motif; other site 220668006345 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 220668006346 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668006347 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 220668006348 NlpC/P60 family; Region: NLPC_P60; pfam00877 220668006349 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 220668006350 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 220668006351 putative DNA binding site [nucleotide binding]; other site 220668006352 putative Zn2+ binding site [ion binding]; other site 220668006353 AsnC family; Region: AsnC_trans_reg; pfam01037 220668006354 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 220668006355 metal binding site [ion binding]; metal-binding site 220668006356 active site 220668006357 I-site; other site 220668006358 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 220668006359 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 220668006360 ABC transporter; Region: ABC_tran_2; pfam12848 220668006361 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 220668006362 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668006363 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 220668006364 Coenzyme A binding pocket [chemical binding]; other site 220668006365 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 220668006366 dimer interface [polypeptide binding]; other site 220668006367 metal binding site [ion binding]; metal-binding site 220668006368 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 220668006369 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 220668006370 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 220668006371 active site turn [active] 220668006372 phosphorylation site [posttranslational modification] 220668006373 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 220668006374 HPr interaction site; other site 220668006375 glycerol kinase (GK) interaction site [polypeptide binding]; other site 220668006376 active site 220668006377 phosphorylation site [posttranslational modification] 220668006378 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 220668006379 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 220668006380 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 220668006381 EDD domain protein, DegV family; Region: DegV; TIGR00762 220668006382 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 220668006383 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 220668006384 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 220668006385 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 220668006386 homodimer interface [polypeptide binding]; other site 220668006387 substrate-cofactor binding pocket; other site 220668006388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668006389 catalytic residue [active] 220668006390 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 220668006391 proposed active site lysine [active] 220668006392 conserved cys residue [active] 220668006393 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 220668006394 zinc binding site [ion binding]; other site 220668006395 putative ligand binding site [chemical binding]; other site 220668006396 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 220668006397 TM-ABC transporter signature motif; other site 220668006398 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 220668006399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668006400 Walker A/P-loop; other site 220668006401 ATP binding site [chemical binding]; other site 220668006402 Q-loop/lid; other site 220668006403 ABC transporter signature motif; other site 220668006404 Walker B; other site 220668006405 D-loop; other site 220668006406 H-loop/switch region; other site 220668006407 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 220668006408 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668006409 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 220668006410 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 220668006411 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 220668006412 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 220668006413 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 220668006414 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 220668006415 maltose O-acetyltransferase; Provisional; Region: PRK10092 220668006416 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 220668006417 active site 220668006418 substrate binding site [chemical binding]; other site 220668006419 trimer interface [polypeptide binding]; other site 220668006420 CoA binding site [chemical binding]; other site 220668006421 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 220668006422 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 220668006423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668006424 homodimer interface [polypeptide binding]; other site 220668006425 catalytic residue [active] 220668006426 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 220668006427 metal binding site [ion binding]; metal-binding site 220668006428 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 220668006429 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 220668006430 substrate binding site [chemical binding]; other site 220668006431 glutamase interaction surface [polypeptide binding]; other site 220668006432 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 220668006433 catalytic residues [active] 220668006434 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 220668006435 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 220668006436 putative active site [active] 220668006437 oxyanion strand; other site 220668006438 catalytic triad [active] 220668006439 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 220668006440 putative active site pocket [active] 220668006441 4-fold oligomerization interface [polypeptide binding]; other site 220668006442 metal binding residues [ion binding]; metal-binding site 220668006443 3-fold/trimer interface [polypeptide binding]; other site 220668006444 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 220668006445 histidinol dehydrogenase; Region: hisD; TIGR00069 220668006446 NAD binding site [chemical binding]; other site 220668006447 dimerization interface [polypeptide binding]; other site 220668006448 product binding site; other site 220668006449 substrate binding site [chemical binding]; other site 220668006450 zinc binding site [ion binding]; other site 220668006451 catalytic residues [active] 220668006452 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 220668006453 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 220668006454 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 220668006455 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 220668006456 dimer interface [polypeptide binding]; other site 220668006457 motif 1; other site 220668006458 active site 220668006459 motif 2; other site 220668006460 motif 3; other site 220668006461 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 220668006462 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 220668006463 active site 220668006464 dimer interface [polypeptide binding]; other site 220668006465 VanZ like family; Region: VanZ; pfam04892 220668006466 RDD family; Region: RDD; pfam06271 220668006467 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 220668006468 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 220668006469 Cl binding site [ion binding]; other site 220668006470 oligomer interface [polypeptide binding]; other site 220668006471 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 220668006472 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 220668006473 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 220668006474 DNA binding residues [nucleotide binding] 220668006475 putative dimer interface [polypeptide binding]; other site 220668006476 short chain dehydrogenase; Provisional; Region: PRK06180 220668006477 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 220668006478 NADP binding site [chemical binding]; other site 220668006479 active site 220668006480 steroid binding site; other site 220668006481 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 220668006482 hydrophobic ligand binding site; other site 220668006483 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 220668006484 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 220668006485 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 220668006486 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 220668006487 active site 220668006488 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 220668006489 Transport protein; Region: actII; TIGR00833 220668006490 Collagen binding domain; Region: Collagen_bind; pfam05737 220668006491 Cna protein B-type domain; Region: Cna_B; pfam05738 220668006492 Cna protein B-type domain; Region: Cna_B; pfam05738 220668006493 Mid-1-related chloride channel (MCLC); Region: MCLC; pfam05934 220668006494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668006495 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 220668006496 Coenzyme A binding pocket [chemical binding]; other site 220668006497 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 220668006498 Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292 220668006499 Sulfatase; Region: Sulfatase; pfam00884 220668006500 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 220668006501 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 220668006502 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 220668006503 putative active site [active] 220668006504 catalytic site [active] 220668006505 putative metal binding site [ion binding]; other site 220668006506 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 220668006507 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668006508 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 220668006509 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668006510 Collagen binding domain; Region: Collagen_bind; pfam05737 220668006511 DHHW protein; Region: DHHW; pfam14286 220668006512 Cornifin (SPRR) family; Region: Cornifin; pfam02389 220668006513 DHHW protein; Region: DHHW; pfam14286 220668006514 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 220668006515 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 220668006516 dimer interface [polypeptide binding]; other site 220668006517 FMN binding site [chemical binding]; other site 220668006518 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 220668006519 active site 220668006520 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 220668006521 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 220668006522 RNA/DNA hybrid binding site [nucleotide binding]; other site 220668006523 active site 220668006524 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 220668006525 Sugar transport protein; Region: Sugar_transport; pfam06800 220668006526 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 220668006527 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 220668006528 nucleotide binding site [chemical binding]; other site 220668006529 Protein of unknown function (DUF3206); Region: DUF3206; pfam11472 220668006530 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 220668006531 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 220668006532 FeS/SAM binding site; other site 220668006533 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 220668006534 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 220668006535 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 220668006536 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 220668006537 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 220668006538 dimer interface [polypeptide binding]; other site 220668006539 active site 220668006540 glycine loop; other site 220668006541 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 220668006542 Helix-turn-helix domain; Region: HTH_28; pfam13518 220668006543 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 220668006544 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 220668006545 active site 220668006546 intersubunit interactions; other site 220668006547 catalytic residue [active] 220668006548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668006549 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 220668006550 active site 220668006551 motif I; other site 220668006552 motif II; other site 220668006553 Transcriptional regulators [Transcription]; Region: PurR; COG1609 220668006554 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 220668006555 DNA binding site [nucleotide binding] 220668006556 domain linker motif; other site 220668006557 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 220668006558 putative dimerization interface [polypeptide binding]; other site 220668006559 putative ligand binding site [chemical binding]; other site 220668006560 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 220668006561 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 220668006562 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 220668006563 putative active site [active] 220668006564 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 220668006565 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 220668006566 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 220668006567 putative oxidoreductase; Provisional; Region: PRK10206 220668006568 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 220668006569 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 220668006570 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 220668006571 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 220668006572 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 220668006573 TPP-binding site; other site 220668006574 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 220668006575 PYR/PP interface [polypeptide binding]; other site 220668006576 dimer interface [polypeptide binding]; other site 220668006577 TPP binding site [chemical binding]; other site 220668006578 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 220668006579 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 220668006580 catalytic triad [active] 220668006581 conserved cis-peptide bond; other site 220668006582 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 220668006583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668006584 Walker A/P-loop; other site 220668006585 ATP binding site [chemical binding]; other site 220668006586 Q-loop/lid; other site 220668006587 ABC transporter signature motif; other site 220668006588 Walker B; other site 220668006589 D-loop; other site 220668006590 H-loop/switch region; other site 220668006591 Predicted transcriptional regulators [Transcription]; Region: COG1725 220668006592 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668006593 DNA-binding site [nucleotide binding]; DNA binding site 220668006594 Enterocin A Immunity; Region: EntA_Immun; pfam08951 220668006595 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 220668006596 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 220668006597 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 220668006598 Transposase; Region: DDE_Tnp_ISL3; pfam01610 220668006599 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668006600 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 220668006601 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 220668006602 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 220668006603 active site 220668006604 Zn binding site [ion binding]; other site 220668006605 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668006606 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668006607 non-specific DNA binding site [nucleotide binding]; other site 220668006608 salt bridge; other site 220668006609 sequence-specific DNA binding site [nucleotide binding]; other site 220668006610 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 220668006611 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 220668006612 PYR/PP interface [polypeptide binding]; other site 220668006613 dimer interface [polypeptide binding]; other site 220668006614 tetramer interface [polypeptide binding]; other site 220668006615 TPP binding site [chemical binding]; other site 220668006616 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 220668006617 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 220668006618 TPP-binding site [chemical binding]; other site 220668006619 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 220668006620 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 220668006621 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 220668006622 catalytic residues [active] 220668006623 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 220668006624 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 220668006625 catalytic residue [active] 220668006626 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 220668006627 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 220668006628 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 220668006629 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 220668006630 autolysin; Reviewed; Region: PRK06347 220668006631 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 220668006632 Bacterial SH3 domain; Region: SH3_5; pfam08460 220668006633 Bacterial SH3 domain; Region: SH3_5; pfam08460 220668006634 Bacterial SH3 domain; Region: SH3_5; pfam08460 220668006635 Bacterial SH3 domain; Region: SH3_5; pfam08460 220668006636 Bacterial SH3 domain; Region: SH3_5; pfam08460 220668006637 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 220668006638 active pocket/dimerization site; other site 220668006639 active site 220668006640 phosphorylation site [posttranslational modification] 220668006641 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 220668006642 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 220668006643 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 220668006644 active site 220668006645 phosphorylation site [posttranslational modification] 220668006646 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 220668006647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668006648 DNA-binding site [nucleotide binding]; DNA binding site 220668006649 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 220668006650 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 220668006651 Ligand Binding Site [chemical binding]; other site 220668006652 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 220668006653 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 220668006654 active site 220668006655 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668006656 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668006657 non-specific DNA binding site [nucleotide binding]; other site 220668006658 salt bridge; other site 220668006659 sequence-specific DNA binding site [nucleotide binding]; other site 220668006660 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 220668006661 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 220668006662 putative ADP-binding pocket [chemical binding]; other site 220668006663 putative phosphoketolase; Provisional; Region: PRK05261 220668006664 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 220668006665 TPP-binding site; other site 220668006666 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 220668006667 XFP C-terminal domain; Region: XFP_C; pfam09363 220668006668 Putative esterase; Region: Esterase; pfam00756 220668006669 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 220668006670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668006671 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 220668006672 DNA-binding site [nucleotide binding]; DNA binding site 220668006673 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 220668006674 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 220668006675 putative deacylase active site [active] 220668006676 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 220668006677 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 220668006678 Zn2+ binding site [ion binding]; other site 220668006679 Mg2+ binding site [ion binding]; other site 220668006680 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 220668006681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 220668006682 active site 220668006683 phosphorylation site [posttranslational modification] 220668006684 intermolecular recognition site; other site 220668006685 dimerization interface [polypeptide binding]; other site 220668006686 LytTr DNA-binding domain; Region: LytTR; smart00850 220668006687 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 220668006688 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 220668006689 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 220668006690 putative dimer interface [polypeptide binding]; other site 220668006691 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 220668006692 Domain of unknown function DUF21; Region: DUF21; pfam01595 220668006693 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 220668006694 Transporter associated domain; Region: CorC_HlyC; smart01091 220668006695 flavoprotein NrdI; Provisional; Region: PRK02551 220668006696 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 220668006697 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 220668006698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668006699 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668006700 putative substrate translocation pore; other site 220668006701 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 220668006702 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 220668006703 DNA binding residues [nucleotide binding] 220668006704 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 220668006705 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 220668006706 putative NAD(P) binding site [chemical binding]; other site 220668006707 SdpI/YhfL protein family; Region: SdpI; pfam13630 220668006708 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 220668006709 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 220668006710 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 220668006711 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 220668006712 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668006713 DNA-binding site [nucleotide binding]; DNA binding site 220668006714 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 220668006715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668006716 homodimer interface [polypeptide binding]; other site 220668006717 aminotransferase A; Validated; Region: PRK07683 220668006718 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 220668006719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668006720 homodimer interface [polypeptide binding]; other site 220668006721 catalytic residue [active] 220668006722 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 220668006723 dimer interface [polypeptide binding]; other site 220668006724 active site 220668006725 catalytic residue [active] 220668006726 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 220668006727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668006728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668006729 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 220668006730 dimerization interface [polypeptide binding]; other site 220668006731 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 220668006732 NAD(P) binding site [chemical binding]; other site 220668006733 putative active site [active] 220668006734 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 220668006735 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 220668006736 Part of AAA domain; Region: AAA_19; pfam13245 220668006737 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 220668006738 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 220668006739 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 220668006740 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 220668006741 Protein of unknown function, DUF606; Region: DUF606; pfam04657 220668006742 Protein of unknown function, DUF606; Region: DUF606; pfam04657 220668006743 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 220668006744 active site 220668006745 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 220668006746 active site 220668006747 dimer interface [polypeptide binding]; other site 220668006748 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 220668006749 heterodimer interface [polypeptide binding]; other site 220668006750 active site 220668006751 FMN binding site [chemical binding]; other site 220668006752 homodimer interface [polypeptide binding]; other site 220668006753 substrate binding site [chemical binding]; other site 220668006754 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 220668006755 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 220668006756 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 220668006757 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 220668006758 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 220668006759 ATP-grasp domain; Region: ATP-grasp_4; cl17255 220668006760 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 220668006761 IMP binding site; other site 220668006762 dimer interface [polypeptide binding]; other site 220668006763 interdomain contacts; other site 220668006764 partial ornithine binding site; other site 220668006765 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 220668006766 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 220668006767 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 220668006768 catalytic site [active] 220668006769 subunit interface [polypeptide binding]; other site 220668006770 dihydroorotase; Validated; Region: pyrC; PRK09357 220668006771 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 220668006772 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 220668006773 active site 220668006774 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 220668006775 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 220668006776 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 220668006777 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 220668006778 active site 220668006779 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 220668006780 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 220668006781 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 220668006782 Sulfate transporter family; Region: Sulfate_transp; cl19250 220668006783 xanthine permease; Region: pbuX; TIGR03173 220668006784 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 220668006785 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 220668006786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 220668006787 NAD(P) binding site [chemical binding]; other site 220668006788 active site 220668006789 EAL domain; Region: EAL; pfam00563 220668006790 N-glycosyltransferase; Provisional; Region: PRK11204 220668006791 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 220668006792 DXD motif; other site 220668006793 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 220668006794 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 220668006795 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 220668006796 ATP-grasp domain; Region: ATP-grasp_4; cl17255 220668006797 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 220668006798 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 220668006799 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 220668006800 purine monophosphate binding site [chemical binding]; other site 220668006801 dimer interface [polypeptide binding]; other site 220668006802 putative catalytic residues [active] 220668006803 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 220668006804 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 220668006805 active site 220668006806 substrate binding site [chemical binding]; other site 220668006807 cosubstrate binding site; other site 220668006808 catalytic site [active] 220668006809 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 220668006810 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 220668006811 dimerization interface [polypeptide binding]; other site 220668006812 putative ATP binding site [chemical binding]; other site 220668006813 amidophosphoribosyltransferase; Provisional; Region: PRK07272 220668006814 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 220668006815 active site 220668006816 tetramer interface [polypeptide binding]; other site 220668006817 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 220668006818 active site 220668006819 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 220668006820 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 220668006821 dimerization interface [polypeptide binding]; other site 220668006822 ATP binding site [chemical binding]; other site 220668006823 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 220668006824 dimerization interface [polypeptide binding]; other site 220668006825 ATP binding site [chemical binding]; other site 220668006826 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 220668006827 putative active site [active] 220668006828 catalytic triad [active] 220668006829 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 220668006830 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 220668006831 ATP binding site [chemical binding]; other site 220668006832 active site 220668006833 substrate binding site [chemical binding]; other site 220668006834 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 220668006835 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 220668006836 NAD binding site [chemical binding]; other site 220668006837 ATP-grasp domain; Region: ATP-grasp_4; cl17255 220668006838 AIR carboxylase; Region: AIRC; pfam00731 220668006839 Predicted flavoprotein [General function prediction only]; Region: COG0431 220668006840 PAS domain; Region: PAS_10; pfam13596 220668006841 Predicted flavoprotein [General function prediction only]; Region: COG0431 220668006842 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 220668006843 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 220668006844 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 220668006845 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 220668006846 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 220668006847 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 220668006848 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 220668006849 active site 220668006850 zinc binding site [ion binding]; other site 220668006851 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668006852 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 220668006853 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 220668006854 active site 220668006855 homotetramer interface [polypeptide binding]; other site 220668006856 homodimer interface [polypeptide binding]; other site 220668006857 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 220668006858 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 220668006859 Walker A/P-loop; other site 220668006860 ATP binding site [chemical binding]; other site 220668006861 Q-loop/lid; other site 220668006862 ABC transporter signature motif; other site 220668006863 Walker B; other site 220668006864 D-loop; other site 220668006865 H-loop/switch region; other site 220668006866 FtsX-like permease family; Region: FtsX; pfam02687 220668006867 Predicted transcriptional regulators [Transcription]; Region: COG1725 220668006868 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668006869 DNA-binding site [nucleotide binding]; DNA binding site 220668006870 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668006871 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 220668006872 Walker A/P-loop; other site 220668006873 ATP binding site [chemical binding]; other site 220668006874 Q-loop/lid; other site 220668006875 ABC transporter signature motif; other site 220668006876 Walker B; other site 220668006877 D-loop; other site 220668006878 H-loop/switch region; other site 220668006879 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 220668006880 Ligand Binding Site [chemical binding]; other site 220668006881 GtrA-like protein; Region: GtrA; pfam04138 220668006882 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 220668006883 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 220668006884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668006885 homodimer interface [polypeptide binding]; other site 220668006886 catalytic residue [active] 220668006887 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 220668006888 homodimer interface [polypeptide binding]; other site 220668006889 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 220668006890 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 220668006891 active site 220668006892 homodimer interface [polypeptide binding]; other site 220668006893 catalytic site [active] 220668006894 threonine synthase; Validated; Region: PRK09225 220668006895 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 220668006896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668006897 catalytic residue [active] 220668006898 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 220668006899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668006900 active site 220668006901 motif I; other site 220668006902 motif II; other site 220668006903 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 220668006904 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 220668006905 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 220668006906 maltose O-acetyltransferase; Provisional; Region: PRK10092 220668006907 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 220668006908 active site 220668006909 substrate binding site [chemical binding]; other site 220668006910 trimer interface [polypeptide binding]; other site 220668006911 CoA binding site [chemical binding]; other site 220668006912 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 220668006913 dimer interface [polypeptide binding]; other site 220668006914 ADP-ribose binding site [chemical binding]; other site 220668006915 active site 220668006916 nudix motif; other site 220668006917 metal binding site [ion binding]; metal-binding site 220668006918 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 220668006919 nucleotide binding site/active site [active] 220668006920 HIT family signature motif; other site 220668006921 catalytic residue [active] 220668006922 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 220668006923 classical (c) SDRs; Region: SDR_c; cd05233 220668006924 NAD(P) binding site [chemical binding]; other site 220668006925 active site 220668006926 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 220668006927 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 220668006928 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 220668006929 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 220668006930 Sterol carrier protein domain; Region: SCP2_2; pfam13530 220668006931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668006932 H+ Antiporter protein; Region: 2A0121; TIGR00900 220668006933 putative substrate translocation pore; other site 220668006934 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 220668006935 HTH domain; Region: HTH_11; pfam08279 220668006936 3H domain; Region: 3H; pfam02829 220668006937 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 220668006938 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 220668006939 active site 220668006940 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668006941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 220668006942 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 220668006943 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 220668006944 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 220668006945 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 220668006946 Walker A/P-loop; other site 220668006947 ATP binding site [chemical binding]; other site 220668006948 Q-loop/lid; other site 220668006949 ABC transporter signature motif; other site 220668006950 Walker B; other site 220668006951 D-loop; other site 220668006952 H-loop/switch region; other site 220668006953 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 220668006954 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 220668006955 catalytic residue [active] 220668006956 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 220668006957 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 220668006958 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 220668006959 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 220668006960 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 220668006961 active site 220668006962 methionine cluster; other site 220668006963 phosphorylation site [posttranslational modification] 220668006964 metal binding site [ion binding]; metal-binding site 220668006965 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 220668006966 active site 220668006967 P-loop; other site 220668006968 phosphorylation site [posttranslational modification] 220668006969 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 220668006970 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668006971 DNA-binding site [nucleotide binding]; DNA binding site 220668006972 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 220668006973 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 220668006974 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 220668006975 active site 220668006976 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 220668006977 catalytic core [active] 220668006978 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668006979 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 220668006980 active site 220668006981 motif I; other site 220668006982 motif II; other site 220668006983 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 220668006984 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 220668006985 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 220668006986 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 220668006987 EamA-like transporter family; Region: EamA; pfam00892 220668006988 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 220668006989 EamA-like transporter family; Region: EamA; pfam00892 220668006990 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 220668006991 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 220668006992 putative ligand binding site [chemical binding]; other site 220668006993 NAD binding site [chemical binding]; other site 220668006994 catalytic site [active] 220668006995 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 220668006996 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 220668006997 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 220668006998 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 220668006999 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 220668007000 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 220668007001 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 220668007002 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 220668007003 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 220668007004 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 220668007005 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 220668007006 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 220668007007 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 220668007008 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 220668007009 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 220668007010 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 220668007011 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 220668007012 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 220668007013 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 220668007014 active site 220668007015 catalytic residue [active] 220668007016 dimer interface [polypeptide binding]; other site 220668007017 inner membrane transporter YjeM; Provisional; Region: PRK15238 220668007018 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668007019 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 220668007020 putative Zn2+ binding site [ion binding]; other site 220668007021 putative DNA binding site [nucleotide binding]; other site 220668007022 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668007023 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 220668007024 putative Zn2+ binding site [ion binding]; other site 220668007025 putative DNA binding site [nucleotide binding]; other site 220668007026 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 220668007027 active site 220668007028 catalytic tetrad [active] 220668007029 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 220668007030 active site 220668007031 catalytic tetrad [active] 220668007032 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668007033 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668007034 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 220668007035 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 220668007036 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 220668007037 active site 220668007038 HIGH motif; other site 220668007039 dimer interface [polypeptide binding]; other site 220668007040 KMSKS motif; other site 220668007041 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 220668007042 RNA binding surface [nucleotide binding]; other site 220668007043 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 220668007044 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 220668007045 active site 220668007046 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 220668007047 putative active site [active] 220668007048 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 220668007049 Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; Region: DHR2_DOCK; cl06123 220668007050 Protein of unknown function (DUF554); Region: DUF554; pfam04474 220668007051 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 220668007052 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 220668007053 DNA binding residues [nucleotide binding] 220668007054 drug binding residues [chemical binding]; other site 220668007055 dimer interface [polypeptide binding]; other site 220668007056 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 220668007057 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 220668007058 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 220668007059 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 220668007060 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 220668007061 FtsX-like permease family; Region: FtsX; pfam02687 220668007062 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 220668007063 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 220668007064 Walker A/P-loop; other site 220668007065 ATP binding site [chemical binding]; other site 220668007066 Q-loop/lid; other site 220668007067 ABC transporter signature motif; other site 220668007068 Walker B; other site 220668007069 D-loop; other site 220668007070 H-loop/switch region; other site 220668007071 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 220668007072 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 220668007073 active site 220668007074 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 220668007075 NADP+ binding site [chemical binding]; other site 220668007076 folate binding site [chemical binding]; other site 220668007077 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 220668007078 Predicted permeases [General function prediction only]; Region: COG0679 220668007079 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 220668007080 Aspartase; Region: Aspartase; cd01357 220668007081 active sites [active] 220668007082 tetramer interface [polypeptide binding]; other site 220668007083 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 220668007084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668007085 putative substrate translocation pore; other site 220668007086 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 220668007087 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 220668007088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668007089 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668007090 putative substrate translocation pore; other site 220668007091 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 220668007092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 220668007093 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 220668007094 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668007095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668007096 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 220668007097 dimerization interface [polypeptide binding]; other site 220668007098 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 220668007099 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 220668007100 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 220668007101 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 220668007102 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 220668007103 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 220668007104 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 220668007105 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 220668007106 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 220668007107 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 220668007108 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 220668007109 DNA binding site [nucleotide binding] 220668007110 active site 220668007111 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 220668007112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668007113 Walker A/P-loop; other site 220668007114 ATP binding site [chemical binding]; other site 220668007115 Q-loop/lid; other site 220668007116 ABC transporter signature motif; other site 220668007117 Walker B; other site 220668007118 D-loop; other site 220668007119 H-loop/switch region; other site 220668007120 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 220668007121 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 220668007122 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 220668007123 classical (c) SDRs; Region: SDR_c; cd05233 220668007124 NAD(P) binding site [chemical binding]; other site 220668007125 active site 220668007126 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 220668007127 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 220668007128 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 220668007129 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 220668007130 DNA binding residues [nucleotide binding] 220668007131 putative dimer interface [polypeptide binding]; other site 220668007132 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 220668007133 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 220668007134 metal binding site [ion binding]; metal-binding site 220668007135 dimer interface [polypeptide binding]; other site 220668007136 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 220668007137 FtsX-like permease family; Region: FtsX; pfam02687 220668007138 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 220668007139 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 220668007140 FtsX-like permease family; Region: FtsX; pfam02687 220668007141 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 220668007142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668007143 ABC transporter signature motif; other site 220668007144 Walker B; other site 220668007145 D-loop; other site 220668007146 H-loop/switch region; other site 220668007147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668007148 Walker A/P-loop; other site 220668007149 ATP binding site [chemical binding]; other site 220668007150 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 220668007151 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 220668007152 minor groove reading motif; other site 220668007153 helix-hairpin-helix signature motif; other site 220668007154 substrate binding pocket [chemical binding]; other site 220668007155 active site 220668007156 maltose O-acetyltransferase; Provisional; Region: PRK10092 220668007157 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 220668007158 active site 220668007159 substrate binding site [chemical binding]; other site 220668007160 trimer interface [polypeptide binding]; other site 220668007161 CoA binding site [chemical binding]; other site 220668007162 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 220668007163 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 220668007164 Catalytic site [active] 220668007165 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 220668007166 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 220668007167 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 220668007168 Catalytic site [active] 220668007169 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 220668007170 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668007171 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 220668007172 Coenzyme A binding pocket [chemical binding]; other site 220668007173 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 220668007174 catalytic core [active] 220668007175 Domain of unknown function (DUF4440); Region: DUF4440; pfam14534 220668007176 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668007177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668007178 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 220668007179 dimerization interface [polypeptide binding]; other site 220668007180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 220668007181 NAD(P) binding site [chemical binding]; other site 220668007182 active site 220668007183 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 220668007184 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 220668007185 catalytic Zn binding site [ion binding]; other site 220668007186 NAD(P) binding site [chemical binding]; other site 220668007187 structural Zn binding site [ion binding]; other site 220668007188 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 220668007189 short chain dehydrogenase; Provisional; Region: PRK06940 220668007190 NAD(P) binding site [chemical binding]; other site 220668007191 active site 220668007192 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 220668007193 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 220668007194 Ligand Binding Site [chemical binding]; other site 220668007195 maltose O-acetyltransferase; Provisional; Region: PRK10092 220668007196 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 220668007197 active site 220668007198 substrate binding site [chemical binding]; other site 220668007199 trimer interface [polypeptide binding]; other site 220668007200 CoA binding site [chemical binding]; other site 220668007201 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 220668007202 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668007203 motif I; other site 220668007204 motif II; other site 220668007205 PemK-like protein; Region: PemK; pfam02452 220668007206 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 220668007207 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 220668007208 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 220668007209 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 220668007210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668007211 homodimer interface [polypeptide binding]; other site 220668007212 catalytic residue [active] 220668007213 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 220668007214 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 220668007215 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 220668007216 active site 220668007217 catalytic tetrad [active] 220668007218 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 220668007219 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 220668007220 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 220668007221 Walker A/P-loop; other site 220668007222 ATP binding site [chemical binding]; other site 220668007223 Q-loop/lid; other site 220668007224 ABC transporter signature motif; other site 220668007225 Walker B; other site 220668007226 D-loop; other site 220668007227 H-loop/switch region; other site 220668007228 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 220668007229 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 220668007230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668007231 Walker A/P-loop; other site 220668007232 ATP binding site [chemical binding]; other site 220668007233 Q-loop/lid; other site 220668007234 ABC transporter signature motif; other site 220668007235 Walker B; other site 220668007236 D-loop; other site 220668007237 H-loop/switch region; other site 220668007238 Predicted membrane protein [Function unknown]; Region: COG1511 220668007239 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 220668007240 DNA circularisation protein N-terminus; Region: DNA_circ_N; cl19561 220668007241 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 220668007242 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 220668007243 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668007244 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 220668007245 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 220668007246 dimerization interface [polypeptide binding]; other site 220668007247 putative DNA binding site [nucleotide binding]; other site 220668007248 putative Zn2+ binding site [ion binding]; other site 220668007249 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 220668007250 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 220668007251 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 220668007252 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 220668007253 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 220668007254 CAAX protease self-immunity; Region: Abi; pfam02517 220668007255 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 220668007256 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 220668007257 ABC transporter; Region: ABC_tran_2; pfam12848 220668007258 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 220668007259 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 220668007260 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 220668007261 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668007262 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 220668007263 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 220668007264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668007265 Walker A/P-loop; other site 220668007266 ATP binding site [chemical binding]; other site 220668007267 Q-loop/lid; other site 220668007268 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 220668007269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668007270 ABC transporter signature motif; other site 220668007271 Walker B; other site 220668007272 D-loop; other site 220668007273 H-loop/switch region; other site 220668007274 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668007275 Walker A/P-loop; other site 220668007276 ATP binding site [chemical binding]; other site 220668007277 Q-loop/lid; other site 220668007278 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 220668007279 ABC transporter signature motif; other site 220668007280 Walker B; other site 220668007281 D-loop; other site 220668007282 H-loop/switch region; other site 220668007283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668007284 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668007285 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668007286 non-specific DNA binding site [nucleotide binding]; other site 220668007287 salt bridge; other site 220668007288 sequence-specific DNA binding site [nucleotide binding]; other site 220668007289 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 220668007290 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668007291 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 220668007292 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 220668007293 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 220668007294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668007295 putative substrate translocation pore; other site 220668007296 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 220668007297 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 220668007298 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 220668007299 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 220668007300 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668007301 DNA-binding site [nucleotide binding]; DNA binding site 220668007302 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 220668007303 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 220668007304 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 220668007305 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 220668007306 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 220668007307 HPr interaction site; other site 220668007308 glycerol kinase (GK) interaction site [polypeptide binding]; other site 220668007309 active site 220668007310 phosphorylation site [posttranslational modification] 220668007311 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 220668007312 metal binding site [ion binding]; metal-binding site 220668007313 active site 220668007314 I-site; other site 220668007315 EAL domain; Region: EAL; pfam00563 220668007316 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 220668007317 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 220668007318 FeS/SAM binding site; other site 220668007319 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 220668007320 Class III ribonucleotide reductase; Region: RNR_III; cd01675 220668007321 effector binding site; other site 220668007322 active site 220668007323 Zn binding site [ion binding]; other site 220668007324 glycine loop; other site 220668007325 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 220668007326 active site 220668007327 catalytic residues [active] 220668007328 metal binding site [ion binding]; metal-binding site 220668007329 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 220668007330 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 220668007331 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 220668007332 FMN binding site [chemical binding]; other site 220668007333 active site 220668007334 catalytic residues [active] 220668007335 substrate binding site [chemical binding]; other site 220668007336 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 220668007337 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668007338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668007339 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 220668007340 dimerization interface [polypeptide binding]; other site 220668007341 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 220668007342 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 220668007343 transmembrane helices; other site 220668007344 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 220668007345 Predicted membrane protein [Function unknown]; Region: COG4640 220668007346 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 220668007347 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 220668007348 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 220668007349 Double zinc ribbon; Region: DZR; pfam12773 220668007350 Enterocin A Immunity; Region: EntA_Immun; pfam08951 220668007351 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668007352 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 220668007353 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668007354 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 220668007355 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 220668007356 Collagen binding domain; Region: Collagen_bind; pfam05737 220668007357 EamA-like transporter family; Region: EamA; pfam00892 220668007358 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 220668007359 EamA-like transporter family; Region: EamA; pfam00892 220668007360 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 220668007361 catalytic triad [active] 220668007362 catalytic triad [active] 220668007363 oxyanion hole [active] 220668007364 Amidohydrolase; Region: Amidohydro_2; pfam04909 220668007365 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668007366 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 220668007367 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 220668007368 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 220668007369 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 220668007370 nucleotide binding site [chemical binding]; other site 220668007371 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 220668007372 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 220668007373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668007374 Walker A/P-loop; other site 220668007375 ATP binding site [chemical binding]; other site 220668007376 Q-loop/lid; other site 220668007377 ABC transporter signature motif; other site 220668007378 Walker B; other site 220668007379 D-loop; other site 220668007380 H-loop/switch region; other site 220668007381 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668007382 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 220668007383 putative Zn2+ binding site [ion binding]; other site 220668007384 putative DNA binding site [nucleotide binding]; other site 220668007385 MarR family; Region: MarR_2; cl17246 220668007386 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 220668007387 dimer interface [polypeptide binding]; other site 220668007388 FMN binding site [chemical binding]; other site 220668007389 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 220668007390 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 220668007391 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 220668007392 active site turn [active] 220668007393 phosphorylation site [posttranslational modification] 220668007394 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 220668007395 HPr interaction site; other site 220668007396 glycerol kinase (GK) interaction site [polypeptide binding]; other site 220668007397 active site 220668007398 phosphorylation site [posttranslational modification] 220668007399 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 220668007400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668007401 Walker A/P-loop; other site 220668007402 ATP binding site [chemical binding]; other site 220668007403 Q-loop/lid; other site 220668007404 ABC transporter signature motif; other site 220668007405 Walker B; other site 220668007406 D-loop; other site 220668007407 H-loop/switch region; other site 220668007408 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 220668007409 TM-ABC transporter signature motif; other site 220668007410 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 220668007411 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 220668007412 zinc binding site [ion binding]; other site 220668007413 putative ligand binding site [chemical binding]; other site 220668007414 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668007415 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 220668007416 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 220668007417 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668007418 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 220668007419 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 220668007420 Walker A/P-loop; other site 220668007421 ATP binding site [chemical binding]; other site 220668007422 Q-loop/lid; other site 220668007423 ABC transporter signature motif; other site 220668007424 Walker B; other site 220668007425 D-loop; other site 220668007426 H-loop/switch region; other site 220668007427 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 220668007428 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 220668007429 Walker A/P-loop; other site 220668007430 ATP binding site [chemical binding]; other site 220668007431 Q-loop/lid; other site 220668007432 ABC transporter signature motif; other site 220668007433 Walker B; other site 220668007434 D-loop; other site 220668007435 H-loop/switch region; other site 220668007436 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 220668007437 TM-ABC transporter signature motif; other site 220668007438 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 220668007439 TM-ABC transporter signature motif; other site 220668007440 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 220668007441 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 220668007442 putative ligand binding site [chemical binding]; other site 220668007443 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 220668007444 active site 220668007445 GtrA-like protein; Region: GtrA; pfam04138 220668007446 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668007447 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668007448 non-specific DNA binding site [nucleotide binding]; other site 220668007449 salt bridge; other site 220668007450 sequence-specific DNA binding site [nucleotide binding]; other site 220668007451 manganese transport protein MntH; Reviewed; Region: PRK00701 220668007452 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 220668007453 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 220668007454 Ligand Binding Site [chemical binding]; other site 220668007455 Uncharacterized conserved protein [Function unknown]; Region: COG0398 220668007456 Cadmium resistance transporter; Region: Cad; cl19409 220668007457 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 220668007458 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 220668007459 Walker A/P-loop; other site 220668007460 ATP binding site [chemical binding]; other site 220668007461 Q-loop/lid; other site 220668007462 ABC transporter signature motif; other site 220668007463 Walker B; other site 220668007464 D-loop; other site 220668007465 H-loop/switch region; other site 220668007466 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 220668007467 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 220668007468 FtsX-like permease family; Region: FtsX; pfam02687 220668007469 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 220668007470 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 220668007471 BDLF3; Provisional; Region: PHA03255 220668007472 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 220668007473 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 220668007474 active site 220668007475 metal binding site [ion binding]; metal-binding site 220668007476 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668007477 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668007478 non-specific DNA binding site [nucleotide binding]; other site 220668007479 salt bridge; other site 220668007480 sequence-specific DNA binding site [nucleotide binding]; other site 220668007481 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 220668007482 glycerol kinase (GK) interaction site [polypeptide binding]; other site 220668007483 HPr interaction site; other site 220668007484 active site 220668007485 phosphorylation site [posttranslational modification] 220668007486 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 220668007487 active site 220668007488 P-loop; other site 220668007489 phosphorylation site [posttranslational modification] 220668007490 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 220668007491 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 220668007492 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 220668007493 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 220668007494 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 220668007495 NADP binding site [chemical binding]; other site 220668007496 putative substrate binding site [chemical binding]; other site 220668007497 active site 220668007498 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 220668007499 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 220668007500 DNA binding residues [nucleotide binding] 220668007501 putative dimer interface [polypeptide binding]; other site 220668007502 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 220668007503 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 220668007504 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 220668007505 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 220668007506 SdpI/YhfL protein family; Region: SdpI; pfam13630 220668007507 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 220668007508 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 220668007509 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 220668007510 metal binding site [ion binding]; metal-binding site 220668007511 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 220668007512 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 220668007513 metal binding site [ion binding]; metal-binding site 220668007514 active site 220668007515 I-site; other site 220668007516 DNA polymerase IV; Reviewed; Region: PRK03103 220668007517 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 220668007518 active site 220668007519 DNA binding site [nucleotide binding] 220668007520 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668007521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668007522 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 220668007523 dimerization interface [polypeptide binding]; other site 220668007524 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 220668007525 classical (c) SDRs; Region: SDR_c; cd05233 220668007526 NAD(P) binding site [chemical binding]; other site 220668007527 active site 220668007528 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 220668007529 putative NAD(P) binding site [chemical binding]; other site 220668007530 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 220668007531 substrate binding site [chemical binding]; other site 220668007532 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 220668007533 Cyclophilin-like; Region: Cyclophil_like; cl17583 220668007534 short chain dehydrogenase; Provisional; Region: PRK06172 220668007535 classical (c) SDRs; Region: SDR_c; cd05233 220668007536 NAD(P) binding site [chemical binding]; other site 220668007537 active site 220668007538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 220668007539 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 220668007540 NAD(P) binding site [chemical binding]; other site 220668007541 active site 220668007542 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 220668007543 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 220668007544 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 220668007545 Transposase; Region: DDE_Tnp_ISL3; pfam01610 220668007546 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 220668007547 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 220668007548 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 220668007549 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 220668007550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668007551 Walker A/P-loop; other site 220668007552 ATP binding site [chemical binding]; other site 220668007553 Q-loop/lid; other site 220668007554 ABC transporter signature motif; other site 220668007555 Walker B; other site 220668007556 D-loop; other site 220668007557 H-loop/switch region; other site 220668007558 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 220668007559 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 220668007560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668007561 Walker A/P-loop; other site 220668007562 ATP binding site [chemical binding]; other site 220668007563 Q-loop/lid; other site 220668007564 ABC transporter signature motif; other site 220668007565 Walker B; other site 220668007566 D-loop; other site 220668007567 H-loop/switch region; other site 220668007568 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 220668007569 active site 220668007570 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 220668007571 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 220668007572 metal binding site [ion binding]; metal-binding site 220668007573 dimer interface [polypeptide binding]; other site 220668007574 oxidoreductase; Provisional; Region: PRK07985 220668007575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 220668007576 NAD(P) binding site [chemical binding]; other site 220668007577 active site 220668007578 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 220668007579 hydrophobic ligand binding site; other site 220668007580 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668007581 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668007582 non-specific DNA binding site [nucleotide binding]; other site 220668007583 salt bridge; other site 220668007584 sequence-specific DNA binding site [nucleotide binding]; other site 220668007585 inner membrane transporter YjeM; Provisional; Region: PRK15238 220668007586 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 220668007587 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 220668007588 dimer interface [polypeptide binding]; other site 220668007589 active site 220668007590 metal binding site [ion binding]; metal-binding site 220668007591 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 220668007592 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 220668007593 catalytic Zn binding site [ion binding]; other site 220668007594 NAD binding site [chemical binding]; other site 220668007595 structural Zn binding site [ion binding]; other site 220668007596 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 220668007597 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 220668007598 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 220668007599 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 220668007600 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 220668007601 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 220668007602 MucBP domain; Region: MucBP; pfam06458 220668007603 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 220668007604 Helix-turn-helix domain; Region: HTH_18; pfam12833 220668007605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 220668007606 TfoX C-terminal domain; Region: TfoX_C; pfam04994 220668007607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 220668007608 ATP binding site [chemical binding]; other site 220668007609 Mg2+ binding site [ion binding]; other site 220668007610 G-X-G motif; other site 220668007611 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668007612 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 220668007613 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 220668007614 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 220668007615 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668007616 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 220668007617 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 220668007618 NAD(P) binding site [chemical binding]; other site 220668007619 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; pfam01521 220668007620 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 220668007621 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 220668007622 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 220668007623 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668007624 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 220668007625 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 220668007626 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 220668007627 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 220668007628 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 220668007629 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 220668007630 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 220668007631 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 220668007632 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 220668007633 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 220668007634 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668007635 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 220668007636 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 220668007637 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668007638 motif II; other site 220668007639 Predicted transcriptional regulators [Transcription]; Region: COG1695 220668007640 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 220668007641 Predicted transcriptional regulators [Transcription]; Region: COG1733 220668007642 putative Zn2+ binding site [ion binding]; other site 220668007643 putative DNA binding site [nucleotide binding]; other site 220668007644 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 220668007645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668007646 putative substrate translocation pore; other site 220668007647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 220668007648 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 220668007649 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 220668007650 active site 220668007651 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 220668007652 dimer interface [polypeptide binding]; other site 220668007653 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 220668007654 Ligand Binding Site [chemical binding]; other site 220668007655 Molecular Tunnel; other site 220668007656 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 220668007657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 220668007658 active site 220668007659 phosphorylation site [posttranslational modification] 220668007660 intermolecular recognition site; other site 220668007661 dimerization interface [polypeptide binding]; other site 220668007662 LytTr DNA-binding domain; Region: LytTR; pfam04397 220668007663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 220668007664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668007665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 220668007666 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 220668007667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 220668007668 NAD(P) binding site [chemical binding]; other site 220668007669 active site 220668007670 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 220668007671 NAD(P) binding site [chemical binding]; other site 220668007672 catalytic residues [active] 220668007673 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 220668007674 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 220668007675 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 220668007676 active site 220668007677 Bacterial SH3 domain; Region: SH3_5; pfam08460 220668007678 Bacterial SH3 domain; Region: SH3_5; pfam08460 220668007679 Bacterial SH3 domain; Region: SH3_5; pfam08460 220668007680 Bacterial SH3 domain; Region: SH3_5; pfam08460 220668007681 Bacterial SH3 domain; Region: SH3_5; pfam08460 220668007682 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 220668007683 Predicted transcriptional regulators [Transcription]; Region: COG1733 220668007684 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 220668007685 classical (c) SDRs; Region: SDR_c; cd05233 220668007686 NAD(P) binding site [chemical binding]; other site 220668007687 active site 220668007688 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668007689 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 220668007690 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 220668007691 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 220668007692 NADP binding site [chemical binding]; other site 220668007693 putative substrate binding site [chemical binding]; other site 220668007694 active site 220668007695 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 220668007696 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 220668007697 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 220668007698 active site 220668007699 catalytic tetrad [active] 220668007700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668007701 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668007702 putative substrate translocation pore; other site 220668007703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668007704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 220668007705 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 220668007706 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 220668007707 intersubunit interface [polypeptide binding]; other site 220668007708 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 220668007709 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 220668007710 Walker A/P-loop; other site 220668007711 ATP binding site [chemical binding]; other site 220668007712 Q-loop/lid; other site 220668007713 ABC transporter signature motif; other site 220668007714 Walker B; other site 220668007715 D-loop; other site 220668007716 H-loop/switch region; other site 220668007717 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 220668007718 ABC-ATPase subunit interface; other site 220668007719 dimer interface [polypeptide binding]; other site 220668007720 putative PBP binding regions; other site 220668007721 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 220668007722 ABC-ATPase subunit interface; other site 220668007723 dimer interface [polypeptide binding]; other site 220668007724 putative PBP binding regions; other site 220668007725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 220668007726 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 220668007727 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 220668007728 putative NAD(P) binding site [chemical binding]; other site 220668007729 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 220668007730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 220668007731 NAD(P) binding site [chemical binding]; other site 220668007732 active site 220668007733 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 220668007734 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 220668007735 putative trimer interface [polypeptide binding]; other site 220668007736 putative CoA binding site [chemical binding]; other site 220668007737 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 220668007738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 220668007739 NAD(P) binding site [chemical binding]; other site 220668007740 active site 220668007741 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 220668007742 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 220668007743 DNA binding residues [nucleotide binding] 220668007744 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 220668007745 Cation channel sperm-associated protein subunit delta; Region: CATSPERD; pfam15020 220668007746 MucBP domain; Region: MucBP; pfam06458 220668007747 MucBP domain; Region: MucBP; pfam06458 220668007748 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 220668007749 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 220668007750 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668007751 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 220668007752 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 220668007753 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 220668007754 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 220668007755 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 220668007756 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 220668007757 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 220668007758 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 220668007759 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 220668007760 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 220668007761 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 220668007762 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668007763 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668007764 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668007765 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 220668007766 GTP-binding protein LepA; Provisional; Region: PRK05433 220668007767 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 220668007768 G1 box; other site 220668007769 putative GEF interaction site [polypeptide binding]; other site 220668007770 GTP/Mg2+ binding site [chemical binding]; other site 220668007771 Switch I region; other site 220668007772 G2 box; other site 220668007773 G3 box; other site 220668007774 Switch II region; other site 220668007775 G4 box; other site 220668007776 G5 box; other site 220668007777 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 220668007778 Elongation Factor G, domain II; Region: EFG_II; pfam14492 220668007779 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 220668007780 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 220668007781 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 220668007782 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 220668007783 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 220668007784 putative NADH binding site [chemical binding]; other site 220668007785 putative active site [active] 220668007786 nudix motif; other site 220668007787 putative metal binding site [ion binding]; other site 220668007788 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668007789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668007790 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 220668007791 dimerization interface [polypeptide binding]; other site 220668007792 hypothetical protein; Validated; Region: PRK07121 220668007793 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668007794 Leucine rich repeat; Region: LRR_8; pfam13855 220668007795 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 220668007796 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 220668007797 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668007798 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668007799 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668007800 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668007801 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 220668007802 Ferritin-like domain; Region: Ferritin; pfam00210 220668007803 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 220668007804 dimerization interface [polypeptide binding]; other site 220668007805 DPS ferroxidase diiron center [ion binding]; other site 220668007806 ion pore; other site 220668007807 transcriptional antiterminator BglG; Provisional; Region: PRK09772 220668007808 CAT RNA binding domain; Region: CAT_RBD; smart01061 220668007809 PRD domain; Region: PRD; pfam00874 220668007810 PRD domain; Region: PRD; pfam00874 220668007811 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 220668007812 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 220668007813 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 220668007814 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 220668007815 active site turn [active] 220668007816 phosphorylation site [posttranslational modification] 220668007817 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 220668007818 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 220668007819 HPr interaction site; other site 220668007820 glycerol kinase (GK) interaction site [polypeptide binding]; other site 220668007821 active site 220668007822 phosphorylation site [posttranslational modification] 220668007823 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 220668007824 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 220668007825 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 220668007826 TPP-binding site [chemical binding]; other site 220668007827 dimer interface [polypeptide binding]; other site 220668007828 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 220668007829 PYR/PP interface [polypeptide binding]; other site 220668007830 dimer interface [polypeptide binding]; other site 220668007831 TPP binding site [chemical binding]; other site 220668007832 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 220668007833 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 220668007834 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 220668007835 active site 220668007836 P-loop; other site 220668007837 phosphorylation site [posttranslational modification] 220668007838 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 220668007839 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 220668007840 DNA binding residues [nucleotide binding] 220668007841 PRD domain; Region: PRD; pfam00874 220668007842 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 220668007843 active site 220668007844 P-loop; other site 220668007845 phosphorylation site [posttranslational modification] 220668007846 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 220668007847 active site 220668007848 phosphorylation site [posttranslational modification] 220668007849 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 220668007850 Double zinc ribbon; Region: DZR; pfam12773 220668007851 Protein of unknown function (DUF805); Region: DUF805; pfam05656 220668007852 Protein of unknown function (DUF3781); Region: DUF3781; pfam12636 220668007853 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 220668007854 intracellular protease, PfpI family; Region: PfpI; TIGR01382 220668007855 conserved cys residue [active] 220668007856 Predicted transcriptional regulators [Transcription]; Region: COG1733 220668007857 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 220668007858 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 220668007859 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 220668007860 putative NAD(P) binding site [chemical binding]; other site 220668007861 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 220668007862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 220668007863 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 220668007864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 220668007865 NAD(P) binding site [chemical binding]; other site 220668007866 active site 220668007867 SnoaL-like domain; Region: SnoaL_4; pfam13577 220668007868 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 220668007869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668007870 putative substrate translocation pore; other site 220668007871 Domain of unknown function (DUF4440); Region: DUF4440; pfam14534 220668007872 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668007873 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 220668007874 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 220668007875 catalytic core [active] 220668007876 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 220668007877 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 220668007878 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 220668007879 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 220668007880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 220668007881 S-adenosylmethionine binding site [chemical binding]; other site 220668007882 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 220668007883 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 220668007884 active site 220668007885 ATP binding site [chemical binding]; other site 220668007886 substrate binding site [chemical binding]; other site 220668007887 activation loop (A-loop); other site 220668007888 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 220668007889 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 220668007890 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 220668007891 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 220668007892 AzlC protein; Region: AzlC; pfam03591 220668007893 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 220668007894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668007895 Coenzyme A binding pocket [chemical binding]; other site 220668007896 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 220668007897 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 220668007898 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 220668007899 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 220668007900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 220668007901 dimer interface [polypeptide binding]; other site 220668007902 phosphorylation site [posttranslational modification] 220668007903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 220668007904 ATP binding site [chemical binding]; other site 220668007905 Mg2+ binding site [ion binding]; other site 220668007906 G-X-G motif; other site 220668007907 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 220668007908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 220668007909 active site 220668007910 phosphorylation site [posttranslational modification] 220668007911 intermolecular recognition site; other site 220668007912 dimerization interface [polypeptide binding]; other site 220668007913 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 220668007914 DNA binding site [nucleotide binding] 220668007915 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 220668007916 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 220668007917 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 220668007918 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 220668007919 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 220668007920 active site 220668007921 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 220668007922 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 220668007923 GTP-binding protein YchF; Reviewed; Region: PRK09601 220668007924 YchF GTPase; Region: YchF; cd01900 220668007925 G1 box; other site 220668007926 GTP/Mg2+ binding site [chemical binding]; other site 220668007927 Switch I region; other site 220668007928 G2 box; other site 220668007929 Switch II region; other site 220668007930 G3 box; other site 220668007931 G4 box; other site 220668007932 G5 box; other site 220668007933 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 220668007934 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 220668007935 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 220668007936 ParB-like nuclease domain; Region: ParB; smart00470 220668007937 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668007938 salt bridge; other site 220668007939 non-specific DNA binding site [nucleotide binding]; other site 220668007940 sequence-specific DNA binding site [nucleotide binding]; other site 220668007941 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 220668007942 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 220668007943 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 220668007944 P-loop; other site 220668007945 Magnesium ion binding site [ion binding]; other site 220668007946 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 220668007947 ParB-like nuclease domain; Region: ParBc; pfam02195 220668007948 KorB domain; Region: KorB; pfam08535 220668007949 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 220668007950 Methyltransferase domain; Region: Methyltransf_31; pfam13847 220668007951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 220668007952 S-adenosylmethionine binding site [chemical binding]; other site 220668007953 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 220668007954 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 220668007955 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 220668007956 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668007957 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668007958 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668007959 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 220668007960 dimerization interface [polypeptide binding]; other site 220668007961 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 220668007962 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 220668007963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668007964 homodimer interface [polypeptide binding]; other site 220668007965 catalytic residue [active] 220668007966 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 220668007967 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 220668007968 substrate binding pocket [chemical binding]; other site 220668007969 membrane-bound complex binding site; other site 220668007970 hinge residues; other site 220668007971 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 220668007972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668007973 dimer interface [polypeptide binding]; other site 220668007974 conserved gate region; other site 220668007975 putative PBP binding loops; other site 220668007976 ABC-ATPase subunit interface; other site 220668007977 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 220668007978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668007979 Walker A/P-loop; other site 220668007980 ATP binding site [chemical binding]; other site 220668007981 Q-loop/lid; other site 220668007982 ABC transporter signature motif; other site 220668007983 Walker B; other site 220668007984 D-loop; other site 220668007985 H-loop/switch region; other site 220668007986 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 220668007987 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 220668007988 substrate binding pocket [chemical binding]; other site 220668007989 membrane-bound complex binding site; other site 220668007990 hinge residues; other site 220668007991 Predicted transcriptional regulators [Transcription]; Region: COG1695 220668007992 putative DNA binding site [nucleotide binding]; other site 220668007993 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 220668007994 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 220668007995 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 220668007996 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 220668007997 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 220668007998 active site turn [active] 220668007999 phosphorylation site [posttranslational modification] 220668008000 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 220668008001 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 220668008002 HPr interaction site; other site 220668008003 glycerol kinase (GK) interaction site [polypeptide binding]; other site 220668008004 active site 220668008005 phosphorylation site [posttranslational modification] 220668008006 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 220668008007 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 220668008008 Ca binding site [ion binding]; other site 220668008009 active site 220668008010 catalytic site [active] 220668008011 Transcriptional regulators [Transcription]; Region: PurR; COG1609 220668008012 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 220668008013 DNA binding site [nucleotide binding] 220668008014 domain linker motif; other site 220668008015 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 220668008016 putative dimerization interface [polypeptide binding]; other site 220668008017 putative ligand binding site [chemical binding]; other site 220668008018 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 220668008019 putative active site [active] 220668008020 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 220668008021 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 220668008022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668008023 Walker A/P-loop; other site 220668008024 ATP binding site [chemical binding]; other site 220668008025 Q-loop/lid; other site 220668008026 ABC transporter signature motif; other site 220668008027 Walker B; other site 220668008028 D-loop; other site 220668008029 H-loop/switch region; other site 220668008030 TRAM domain; Region: TRAM; cl01282 220668008031 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 220668008032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 220668008033 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 220668008034 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 220668008035 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 220668008036 active site turn [active] 220668008037 phosphorylation site [posttranslational modification] 220668008038 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 220668008039 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 220668008040 HPr interaction site; other site 220668008041 glycerol kinase (GK) interaction site [polypeptide binding]; other site 220668008042 active site 220668008043 phosphorylation site [posttranslational modification] 220668008044 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 220668008045 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 220668008046 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668008047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668008048 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 220668008049 dimerization interface [polypeptide binding]; other site 220668008050 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 220668008051 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 220668008052 NADP binding site [chemical binding]; other site 220668008053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668008054 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 220668008055 active site 220668008056 motif I; other site 220668008057 motif II; other site 220668008058 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 220668008059 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 220668008060 DNA binding residues [nucleotide binding] 220668008061 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 220668008062 putative dimer interface [polypeptide binding]; other site 220668008063 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 220668008064 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 220668008065 NADP binding site [chemical binding]; other site 220668008066 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 220668008067 HPr interaction site; other site 220668008068 glycerol kinase (GK) interaction site [polypeptide binding]; other site 220668008069 active site 220668008070 phosphorylation site [posttranslational modification] 220668008071 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 220668008072 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 220668008073 active site turn [active] 220668008074 phosphorylation site [posttranslational modification] 220668008075 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 220668008076 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 220668008077 minor groove reading motif; other site 220668008078 helix-hairpin-helix signature motif; other site 220668008079 substrate binding pocket [chemical binding]; other site 220668008080 active site 220668008081 Predicted flavoprotein [General function prediction only]; Region: COG0431 220668008082 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 220668008083 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 220668008084 metal binding site 2 [ion binding]; metal-binding site 220668008085 putative DNA binding helix; other site 220668008086 metal binding site 1 [ion binding]; metal-binding site 220668008087 dimer interface [polypeptide binding]; other site 220668008088 structural Zn2+ binding site [ion binding]; other site 220668008089 Enterocin A Immunity; Region: EntA_Immun; pfam08951 220668008090 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 220668008091 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 220668008092 active site 220668008093 metal binding site [ion binding]; metal-binding site 220668008094 hexamer interface [polypeptide binding]; other site 220668008095 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 220668008096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668008097 Coenzyme A binding pocket [chemical binding]; other site 220668008098 LrgA family; Region: LrgA; cl00608 220668008099 LrgB-like family; Region: LrgB; cl00596 220668008100 EDD domain protein, DegV family; Region: DegV; TIGR00762 220668008101 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 220668008102 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668008103 phytoene desaturase; Region: crtI_fam; TIGR02734 220668008104 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 220668008105 active site lid residues [active] 220668008106 substrate binding pocket [chemical binding]; other site 220668008107 catalytic residues [active] 220668008108 substrate-Mg2+ binding site; other site 220668008109 aspartate-rich region 1; other site 220668008110 aspartate-rich region 2; other site 220668008111 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668008112 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 220668008113 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 220668008114 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 220668008115 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668008116 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 220668008117 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 220668008118 Enterocin A Immunity; Region: EntA_Immun; pfam08951 220668008119 adenylosuccinate lyase; Provisional; Region: PRK07492 220668008120 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 220668008121 tetramer interface [polypeptide binding]; other site 220668008122 active site 220668008123 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 220668008124 GDP-binding site [chemical binding]; other site 220668008125 ACT binding site; other site 220668008126 IMP binding site; other site 220668008127 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 220668008128 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 220668008129 active site 220668008130 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 220668008131 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 220668008132 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 220668008133 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 220668008134 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 220668008135 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 220668008136 putative active site [active] 220668008137 catalytic site [active] 220668008138 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 220668008139 putative active site [active] 220668008140 catalytic site [active] 220668008141 amino acid transporter; Region: 2A0306; TIGR00909 220668008142 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 220668008143 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 220668008144 K+ potassium transporter; Region: K_trans; pfam02705 220668008145 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 220668008146 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 220668008147 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 220668008148 substrate binding site [chemical binding]; other site 220668008149 THF binding site; other site 220668008150 zinc-binding site [ion binding]; other site 220668008151 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 220668008152 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 220668008153 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 220668008154 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 220668008155 dimerization interface [polypeptide binding]; other site 220668008156 putative DNA binding site [nucleotide binding]; other site 220668008157 putative Zn2+ binding site [ion binding]; other site 220668008158 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 220668008159 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 220668008160 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668008161 non-specific DNA binding site [nucleotide binding]; other site 220668008162 salt bridge; other site 220668008163 sequence-specific DNA binding site [nucleotide binding]; other site 220668008164 flagellar motor protein MotB; Validated; Region: motB; PRK09041 220668008165 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 220668008166 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 220668008167 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 220668008168 substrate binding pocket [chemical binding]; other site 220668008169 dimer interface [polypeptide binding]; other site 220668008170 inhibitor binding site; inhibition site 220668008171 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 220668008172 active site 220668008173 dimerization interface [polypeptide binding]; other site 220668008174 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 220668008175 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 220668008176 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 220668008177 GTP cyclohydrolase I; Region: GTP_cyclohydroI; pfam01227 220668008178 active site 220668008179 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 220668008180 catalytic center binding site [active] 220668008181 ATP binding site [chemical binding]; other site 220668008182 Dihydroneopterin aldolase; Region: FolB; pfam02152 220668008183 active site 220668008184 Colicin V production protein; Region: Colicin_V; pfam02674 220668008185 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 220668008186 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 220668008187 intersubunit interface [polypeptide binding]; other site 220668008188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668008189 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668008190 putative substrate translocation pore; other site 220668008191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 220668008192 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 220668008193 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 220668008194 Transposase; Region: DDE_Tnp_ISL3; pfam01610 220668008195 VanZ like family; Region: VanZ; cl01971 220668008196 Beta-lactamase; Region: Beta-lactamase; pfam00144 220668008197 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 220668008198 Pyruvate formate lyase 1; Region: PFL1; cd01678 220668008199 coenzyme A binding site [chemical binding]; other site 220668008200 active site 220668008201 catalytic residues [active] 220668008202 glycine loop; other site 220668008203 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 220668008204 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 220668008205 FeS/SAM binding site; other site 220668008206 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 220668008207 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 220668008208 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 220668008209 active site 220668008210 catalytic tetrad [active] 220668008211 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 220668008212 nucleotide binding site/active site [active] 220668008213 HIT family signature motif; other site 220668008214 catalytic residue [active] 220668008215 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 220668008216 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 220668008217 active site 220668008218 catalytic triad [active] 220668008219 oxyanion hole [active] 220668008220 BCCT family transporter; Region: BCCT; pfam02028 220668008221 Fungal pheromone mating factor STE2 GPCR; Region: STE2; pfam02116 220668008222 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 220668008223 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 220668008224 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 220668008225 YjbR; Region: YjbR; cl15265 220668008226 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 220668008227 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 220668008228 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 220668008229 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 220668008230 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 220668008231 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 220668008232 active site 220668008233 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 220668008234 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 220668008235 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 220668008236 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 220668008237 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 220668008238 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 220668008239 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 220668008240 Na binding site [ion binding]; other site 220668008241 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668008242 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 220668008243 tetramer interfaces [polypeptide binding]; other site 220668008244 binuclear metal-binding site [ion binding]; other site 220668008245 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 220668008246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 220668008247 NAD(P) binding site [chemical binding]; other site 220668008248 active site 220668008249 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668008250 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 220668008251 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 220668008252 putative catalytic residues [active] 220668008253 thiol/disulfide switch; other site 220668008254 Protein of unknown function, DUF488; Region: DUF488; cl01246 220668008255 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 220668008256 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 220668008257 minor groove reading motif; other site 220668008258 helix-hairpin-helix signature motif; other site 220668008259 substrate binding pocket [chemical binding]; other site 220668008260 active site 220668008261 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 220668008262 DNA binding and oxoG recognition site [nucleotide binding] 220668008263 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 220668008264 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 220668008265 putative dimer interface [polypeptide binding]; other site 220668008266 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 220668008267 putative NAD(P) binding site [chemical binding]; other site 220668008268 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 220668008269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668008270 Coenzyme A binding pocket [chemical binding]; other site 220668008271 EamA-like transporter family; Region: EamA; pfam00892 220668008272 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 220668008273 EamA-like transporter family; Region: EamA; pfam00892 220668008274 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 220668008275 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 220668008276 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 220668008277 active site 220668008278 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 220668008279 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 220668008280 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 220668008281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668008282 motif II; other site 220668008283 Penicillinase repressor; Region: Penicillinase_R; cl17580 220668008284 zinc-finger; Region: zf-RING_3; pfam14369 220668008285 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 220668008286 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 220668008287 Na binding site [ion binding]; other site 220668008288 Putative lysophospholipase; Region: Hydrolase_4; cl19140 220668008289 D5 N terminal like; Region: D5_N; smart00885 220668008290 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 220668008291 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 220668008292 polymerase nucleotide-binding site; other site 220668008293 DNA-binding residues [nucleotide binding]; DNA binding site 220668008294 nucleotide binding site [chemical binding]; other site 220668008295 primase nucleotide-binding site [nucleotide binding]; other site 220668008296 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 220668008297 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 220668008298 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 220668008299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668008300 sequence-specific DNA binding site [nucleotide binding]; other site 220668008301 salt bridge; other site 220668008302 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 220668008303 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 220668008304 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 220668008305 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 220668008306 Int/Topo IB signature motif; other site 220668008307 drug efflux system protein MdtG; Provisional; Region: PRK09874 220668008308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668008309 putative substrate translocation pore; other site 220668008310 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 220668008311 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 220668008312 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 220668008313 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 220668008314 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 220668008315 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 220668008316 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 220668008317 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 220668008318 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668008319 active site 220668008320 motif I; other site 220668008321 motif II; other site 220668008322 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 220668008323 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 220668008324 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 220668008325 active site 220668008326 metal binding site [ion binding]; metal-binding site 220668008327 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 220668008328 Membrane transport protein; Region: Mem_trans; cl09117 220668008329 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 220668008330 active site 220668008331 catalytic tetrad [active] 220668008332 Uncharacterized conserved protein [Function unknown]; Region: COG2966 220668008333 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 220668008334 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 220668008335 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 220668008336 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 220668008337 putative ADP-ribose binding site [chemical binding]; other site 220668008338 putative active site [active] 220668008339 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 220668008340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668008341 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 220668008342 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668008343 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 220668008344 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 220668008345 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668008346 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 220668008347 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 220668008348 Transcriptional regulators [Transcription]; Region: MarR; COG1846 220668008349 MarR family; Region: MarR_2; pfam12802 220668008350 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668008351 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 220668008352 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 220668008353 active site 220668008354 metal-binding site [ion binding] 220668008355 active site 220668008356 nucleotide-binding site [chemical binding]; other site 220668008357 nucleotide-binding site [chemical binding]; other site 220668008358 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 220668008359 non-specific DNA binding site [nucleotide binding]; other site 220668008360 salt bridge; other site 220668008361 sequence-specific DNA binding site [nucleotide binding]; other site 220668008362 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 220668008363 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 220668008364 catalytic residue [active] 220668008365 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 220668008366 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 220668008367 NlpC/P60 family; Region: NLPC_P60; pfam00877 220668008368 SnoaL-like domain; Region: SnoaL_4; pfam13577 220668008369 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 220668008370 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 220668008371 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668008372 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 220668008373 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 220668008374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 220668008375 S-adenosylmethionine binding site [chemical binding]; other site 220668008376 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 220668008377 putative active site [active] 220668008378 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 220668008379 active site 220668008380 catalytic triad [active] 220668008381 oxyanion hole [active] 220668008382 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 220668008383 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 220668008384 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 220668008385 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 220668008386 amphipathic channel; other site 220668008387 Asn-Pro-Ala signature motifs; other site 220668008388 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 220668008389 catalytic residues [active] 220668008390 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 220668008391 putative homodimer interface [polypeptide binding]; other site 220668008392 putative homotetramer interface [polypeptide binding]; other site 220668008393 putative metal binding site [ion binding]; other site 220668008394 putative homodimer-homodimer interface [polypeptide binding]; other site 220668008395 putative allosteric switch controlling residues; other site 220668008396 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 220668008397 Ferritin-like domain; Region: Ferritin; pfam00210 220668008398 dimerization interface [polypeptide binding]; other site 220668008399 DPS ferroxidase diiron center [ion binding]; other site 220668008400 ion pore; other site 220668008401 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 220668008402 metal-binding site [ion binding] 220668008403 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 220668008404 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 220668008405 ligand binding site [chemical binding]; other site 220668008406 flexible hinge region; other site 220668008407 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 220668008408 non-specific DNA interactions [nucleotide binding]; other site 220668008409 DNA binding site [nucleotide binding] 220668008410 sequence specific DNA binding site [nucleotide binding]; other site 220668008411 putative cAMP binding site [chemical binding]; other site 220668008412 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 220668008413 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 220668008414 active site 220668008415 Zn binding site [ion binding]; other site 220668008416 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 220668008417 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 220668008418 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668008419 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 220668008420 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 220668008421 legume lectins; Region: lectin_L-type; cl14058 220668008422 homodimer interaction site [polypeptide binding]; other site 220668008423 homotetramer interaction site [polypeptide binding]; other site 220668008424 carbohydrate binding site [chemical binding]; other site 220668008425 metal binding site [ion binding]; metal-binding site 220668008426 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668008427 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 220668008428 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 220668008429 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668008430 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668008431 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 220668008432 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 220668008433 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 220668008434 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 220668008435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668008436 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 220668008437 Walker A motif; other site 220668008438 ATP binding site [chemical binding]; other site 220668008439 Walker B motif; other site 220668008440 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 220668008441 amphipathic channel; other site 220668008442 Asn-Pro-Ala signature motifs; other site 220668008443 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 220668008444 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 220668008445 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 220668008446 putative symporter YagG; Provisional; Region: PRK09669; cl15392 220668008447 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 220668008448 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 220668008449 HPr interaction site; other site 220668008450 glycerol kinase (GK) interaction site [polypeptide binding]; other site 220668008451 active site 220668008452 phosphorylation site [posttranslational modification] 220668008453 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 220668008454 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 220668008455 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 220668008456 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 220668008457 Transcriptional regulators [Transcription]; Region: PurR; COG1609 220668008458 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 220668008459 DNA binding site [nucleotide binding] 220668008460 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 220668008461 putative dimerization interface [polypeptide binding]; other site 220668008462 putative ligand binding site [chemical binding]; other site 220668008463 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 220668008464 benzoate transport; Region: 2A0115; TIGR00895 220668008465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668008466 putative substrate translocation pore; other site 220668008467 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 220668008468 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668008469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668008470 putative substrate translocation pore; other site 220668008471 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 220668008472 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 220668008473 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 220668008474 Fic/DOC family; Region: Fic; cl00960 220668008475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668008476 non-specific DNA binding site [nucleotide binding]; other site 220668008477 salt bridge; other site 220668008478 sequence-specific DNA binding site [nucleotide binding]; other site 220668008479 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 220668008480 FIC domain binding interface [polypeptide binding]; other site 220668008481 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 220668008482 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 220668008483 DNA binding site [nucleotide binding] 220668008484 domain linker motif; other site 220668008485 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 220668008486 putative dimerization interface [polypeptide binding]; other site 220668008487 putative ligand binding site [chemical binding]; other site 220668008488 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 220668008489 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 220668008490 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 220668008491 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 220668008492 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 220668008493 NAD binding site [chemical binding]; other site 220668008494 homodimer interface [polypeptide binding]; other site 220668008495 active site 220668008496 substrate binding site [chemical binding]; other site 220668008497 galactokinase; Provisional; Region: PRK05322 220668008498 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 220668008499 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 220668008500 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 220668008501 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 220668008502 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 220668008503 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 220668008504 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 220668008505 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 220668008506 Melibiase; Region: Melibiase; pfam02065 220668008507 putative symporter YagG; Provisional; Region: PRK09669; cl15392 220668008508 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 220668008509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668008510 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 220668008511 HPr interaction site; other site 220668008512 glycerol kinase (GK) interaction site [polypeptide binding]; other site 220668008513 active site 220668008514 phosphorylation site [posttranslational modification] 220668008515 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 220668008516 active site 220668008517 catalytic residues [active] 220668008518 Transcriptional regulators [Transcription]; Region: PurR; COG1609 220668008519 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 220668008520 DNA binding site [nucleotide binding] 220668008521 domain linker motif; other site 220668008522 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 220668008523 putative dimerization interface [polypeptide binding]; other site 220668008524 putative ligand binding site [chemical binding]; other site 220668008525 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 220668008526 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 220668008527 active site 220668008528 catalytic tetrad [active] 220668008529 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 220668008530 FMN-binding domain; Region: FMN_bind; cl01081 220668008531 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 220668008532 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668008533 Predicted flavoprotein [General function prediction only]; Region: COG0431 220668008534 ApbE family; Region: ApbE; pfam02424 220668008535 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 220668008536 active site 220668008537 catalytic residue [active] 220668008538 dimer interface [polypeptide binding]; other site 220668008539 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 220668008540 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 220668008541 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 220668008542 shikimate binding site; other site 220668008543 NAD(P) binding site [chemical binding]; other site 220668008544 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668008545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668008546 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 220668008547 putative dimerization interface [polypeptide binding]; other site 220668008548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 220668008549 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 220668008550 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 220668008551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668008552 putative substrate translocation pore; other site 220668008553 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668008554 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 220668008555 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 220668008556 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 220668008557 shikimate binding site; other site 220668008558 NAD(P) binding site [chemical binding]; other site 220668008559 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 220668008560 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 220668008561 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 220668008562 shikimate binding site; other site 220668008563 NAD(P) binding site [chemical binding]; other site 220668008564 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 220668008565 classical (c) SDRs; Region: SDR_c; cd05233 220668008566 NAD(P) binding site [chemical binding]; other site 220668008567 active site 220668008568 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 220668008569 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 220668008570 Transcriptional regulator [Transcription]; Region: LysR; COG0583 220668008571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 220668008572 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 220668008573 putative dimerization interface [polypeptide binding]; other site 220668008574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668008575 Major Facilitator Superfamily; Region: MFS_1; pfam07690 220668008576 putative substrate translocation pore; other site 220668008577 Putative esterase; Region: Esterase; pfam00756 220668008578 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 220668008579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 220668008580 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 220668008581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668008582 DNA-binding site [nucleotide binding]; DNA binding site 220668008583 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 220668008584 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 220668008585 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 220668008586 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 220668008587 putative active site [active] 220668008588 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 220668008589 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 220668008590 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 220668008591 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 220668008592 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 220668008593 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 220668008594 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 220668008595 active site turn [active] 220668008596 phosphorylation site [posttranslational modification] 220668008597 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 220668008598 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 220668008599 HPr interaction site; other site 220668008600 glycerol kinase (GK) interaction site [polypeptide binding]; other site 220668008601 active site 220668008602 phosphorylation site [posttranslational modification] 220668008603 transcriptional antiterminator BglG; Provisional; Region: PRK09772 220668008604 CAT RNA binding domain; Region: CAT_RBD; smart01061 220668008605 PRD domain; Region: PRD; pfam00874 220668008606 PRD domain; Region: PRD; pfam00874 220668008607 putative frv operon regulatory protein; Provisional; Region: PRK09863 220668008608 HTH domain; Region: HTH_11; pfam08279 220668008609 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 220668008610 active site 220668008611 phosphorylation site [posttranslational modification] 220668008612 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 220668008613 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 220668008614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 220668008615 homodimer interface [polypeptide binding]; other site 220668008616 catalytic residue [active] 220668008617 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 220668008618 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 220668008619 active site 220668008620 P-loop; other site 220668008621 phosphorylation site [posttranslational modification] 220668008622 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 220668008623 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 220668008624 active site 220668008625 phosphorylation site [posttranslational modification] 220668008626 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 220668008627 HPr interaction site; other site 220668008628 glycerol kinase (GK) interaction site [polypeptide binding]; other site 220668008629 active site 220668008630 phosphorylation site [posttranslational modification] 220668008631 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 220668008632 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 220668008633 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 220668008634 putative active site [active] 220668008635 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 220668008636 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 220668008637 active site turn [active] 220668008638 phosphorylation site [posttranslational modification] 220668008639 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 220668008640 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 220668008641 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 220668008642 putative active site [active] 220668008643 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 220668008644 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 220668008645 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 220668008646 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 220668008647 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 220668008648 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 220668008649 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 220668008650 active site turn [active] 220668008651 phosphorylation site [posttranslational modification] 220668008652 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 220668008653 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 220668008654 HPr interaction site; other site 220668008655 glycerol kinase (GK) interaction site [polypeptide binding]; other site 220668008656 active site 220668008657 phosphorylation site [posttranslational modification] 220668008658 transcriptional antiterminator BglG; Provisional; Region: PRK09772 220668008659 CAT RNA binding domain; Region: CAT_RBD; smart01061 220668008660 PRD domain; Region: PRD; pfam00874 220668008661 PRD domain; Region: PRD; pfam00874 220668008662 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 220668008663 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 220668008664 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 220668008665 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 220668008666 Transcriptional regulators [Transcription]; Region: PurR; COG1609 220668008667 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 220668008668 DNA binding site [nucleotide binding] 220668008669 domain linker motif; other site 220668008670 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 220668008671 dimerization interface [polypeptide binding]; other site 220668008672 ligand binding site [chemical binding]; other site 220668008673 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 220668008674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668008675 putative substrate translocation pore; other site 220668008676 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 220668008677 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 220668008678 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 220668008679 trimer interface [polypeptide binding]; other site 220668008680 active site 220668008681 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 220668008682 catalytic site [active] 220668008683 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 220668008684 active site 220668008685 sugar phosphate phosphatase; Provisional; Region: PRK10513 220668008686 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668008687 active site 220668008688 motif I; other site 220668008689 motif II; other site 220668008690 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 220668008691 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 220668008692 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 220668008693 TPP-binding site [chemical binding]; other site 220668008694 dimer interface [polypeptide binding]; other site 220668008695 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 220668008696 PYR/PP interface [polypeptide binding]; other site 220668008697 dimer interface [polypeptide binding]; other site 220668008698 TPP binding site [chemical binding]; other site 220668008699 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 220668008700 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 220668008701 active site 220668008702 intersubunit interactions; other site 220668008703 catalytic residue [active] 220668008704 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 220668008705 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 220668008706 active site 220668008707 P-loop; other site 220668008708 phosphorylation site [posttranslational modification] 220668008709 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 220668008710 active site 220668008711 phosphorylation site [posttranslational modification] 220668008712 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 220668008713 PRD domain; Region: PRD; pfam00874 220668008714 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 220668008715 active site 220668008716 P-loop; other site 220668008717 phosphorylation site [posttranslational modification] 220668008718 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 220668008719 active site 220668008720 phosphorylation site [posttranslational modification] 220668008721 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 220668008722 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 220668008723 motif II; other site 220668008724 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 220668008725 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 220668008726 putative NAD(P) binding site [chemical binding]; other site 220668008727 catalytic Zn binding site [ion binding]; other site 220668008728 structural Zn binding site [ion binding]; other site 220668008729 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 220668008730 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 220668008731 active site 220668008732 P-loop; other site 220668008733 phosphorylation site [posttranslational modification] 220668008734 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 220668008735 active site 220668008736 phosphorylation site [posttranslational modification] 220668008737 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 220668008738 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 220668008739 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 220668008740 putative phosphoketolase; Provisional; Region: PRK05261 220668008741 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 220668008742 TPP-binding site; other site 220668008743 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 220668008744 XFP C-terminal domain; Region: XFP_C; pfam09363 220668008745 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 220668008746 maltose O-acetyltransferase; Provisional; Region: PRK10092 220668008747 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 220668008748 active site 220668008749 substrate binding site [chemical binding]; other site 220668008750 trimer interface [polypeptide binding]; other site 220668008751 CoA binding site [chemical binding]; other site 220668008752 L-arabinose isomerase; Provisional; Region: PRK02929 220668008753 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 220668008754 hexamer (dimer of trimers) interface [polypeptide binding]; other site 220668008755 substrate binding site [chemical binding]; other site 220668008756 trimer interface [polypeptide binding]; other site 220668008757 Mn binding site [ion binding]; other site 220668008758 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 220668008759 intersubunit interface [polypeptide binding]; other site 220668008760 active site 220668008761 Zn2+ binding site [ion binding]; other site 220668008762 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 220668008763 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 220668008764 putative N- and C-terminal domain interface [polypeptide binding]; other site 220668008765 putative active site [active] 220668008766 MgATP binding site [chemical binding]; other site 220668008767 catalytic site [active] 220668008768 metal binding site [ion binding]; metal-binding site 220668008769 putative carbohydrate binding site [chemical binding]; other site 220668008770 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 220668008771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668008772 putative substrate translocation pore; other site 220668008773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668008774 DNA-binding site [nucleotide binding]; DNA binding site 220668008775 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 220668008776 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 220668008777 putative dimerization interface [polypeptide binding]; other site 220668008778 putative ligand binding site [chemical binding]; other site 220668008779 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 220668008780 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 220668008781 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 220668008782 putative active site [active] 220668008783 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 220668008784 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 220668008785 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 220668008786 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 220668008787 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 220668008788 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 220668008789 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 220668008790 Na binding site [ion binding]; other site 220668008791 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 220668008792 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 220668008793 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 220668008794 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 220668008795 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 220668008796 nucleotide binding site [chemical binding]; other site 220668008797 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 220668008798 inhibitor site; inhibition site 220668008799 active site 220668008800 dimer interface [polypeptide binding]; other site 220668008801 catalytic residue [active] 220668008802 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 220668008803 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 220668008804 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 220668008805 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 220668008806 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 220668008807 putative active site cavity [active] 220668008808 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 220668008809 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668008810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 220668008811 conserved hypothetical protein; Region: TIGR02328 220668008812 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 220668008813 Predicted membrane protein [Function unknown]; Region: COG2261 220668008814 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 220668008815 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 220668008816 heme binding pocket [chemical binding]; other site 220668008817 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 220668008818 putative catalytic residues [active] 220668008819 thiol/disulfide switch; other site 220668008820 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 220668008821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 220668008822 active site 220668008823 phosphorylation site [posttranslational modification] 220668008824 intermolecular recognition site; other site 220668008825 dimerization interface [polypeptide binding]; other site 220668008826 LytTr DNA-binding domain; Region: LytTR; pfam04397 220668008827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 220668008828 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 220668008829 Accessory gene regulator B; Region: AgrB; smart00793 220668008830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668008831 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 220668008832 Walker A motif; other site 220668008833 ATP binding site [chemical binding]; other site 220668008834 Walker B motif; other site 220668008835 arginine finger; other site 220668008836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 220668008837 Walker A motif; other site 220668008838 ATP binding site [chemical binding]; other site 220668008839 Walker B motif; other site 220668008840 arginine finger; other site 220668008841 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 220668008842 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 220668008843 teramer interface [polypeptide binding]; other site 220668008844 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 220668008845 active site 220668008846 FMN binding site [chemical binding]; other site 220668008847 catalytic residues [active] 220668008848 pyruvate oxidase; Provisional; Region: PRK08611 220668008849 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 220668008850 PYR/PP interface [polypeptide binding]; other site 220668008851 dimer interface [polypeptide binding]; other site 220668008852 tetramer interface [polypeptide binding]; other site 220668008853 TPP binding site [chemical binding]; other site 220668008854 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 220668008855 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 220668008856 TPP-binding site [chemical binding]; other site 220668008857 Transcriptional regulator; Region: Rrf2; pfam02082 220668008858 Rrf2 family protein; Region: rrf2_super; TIGR00738 220668008859 Transcriptional regulator; Region: Rrf2; cl17282 220668008860 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 220668008861 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 220668008862 PYR/PP interface [polypeptide binding]; other site 220668008863 dimer interface [polypeptide binding]; other site 220668008864 tetramer interface [polypeptide binding]; other site 220668008865 TPP binding site [chemical binding]; other site 220668008866 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 220668008867 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 220668008868 TPP-binding site [chemical binding]; other site 220668008869 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 220668008870 Predicted membrane protein [Function unknown]; Region: COG2364 220668008871 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 220668008872 intersubunit interface [polypeptide binding]; other site 220668008873 active site 220668008874 Zn2+ binding site [ion binding]; other site 220668008875 L-rhamnose isomerase; Provisional; Region: PRK01076 220668008876 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 220668008877 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 220668008878 N- and C-terminal domain interface [polypeptide binding]; other site 220668008879 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 220668008880 active site 220668008881 putative catalytic site [active] 220668008882 metal binding site [ion binding]; metal-binding site 220668008883 ATP binding site [chemical binding]; other site 220668008884 carbohydrate binding site [chemical binding]; other site 220668008885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668008886 putative substrate translocation pore; other site 220668008887 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 220668008888 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 220668008889 Cupin domain; Region: Cupin_2; cl17218 220668008890 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 220668008891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 220668008892 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 220668008893 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 220668008894 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 220668008895 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 220668008896 active site 220668008897 phosphorylation site [posttranslational modification] 220668008898 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 220668008899 active site 220668008900 P-loop; other site 220668008901 phosphorylation site [posttranslational modification] 220668008902 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 220668008903 hypothetical protein; Provisional; Region: PRK06357 220668008904 intersubunit interface [polypeptide binding]; other site 220668008905 active site 220668008906 Zn2+ binding site [ion binding]; other site 220668008907 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 220668008908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668008909 putative substrate translocation pore; other site 220668008910 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 220668008911 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 220668008912 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 220668008913 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 220668008914 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 220668008915 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 220668008916 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 220668008917 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 220668008918 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 220668008919 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 220668008920 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 220668008921 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 220668008922 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 220668008923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668008924 putative substrate translocation pore; other site 220668008925 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 220668008926 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 220668008927 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 220668008928 hypothetical protein; Provisional; Region: PRK02487 220668008929 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 220668008930 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 220668008931 putative NAD(P) binding site [chemical binding]; other site 220668008932 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 220668008933 active site 220668008934 tetramer interface [polypeptide binding]; other site 220668008935 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 220668008936 active site 220668008937 intersubunit interactions; other site 220668008938 catalytic residue [active] 220668008939 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 220668008940 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 220668008941 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 220668008942 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 220668008943 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 220668008944 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 220668008945 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 220668008946 HTH domain; Region: HTH_11; pfam08279 220668008947 PRD domain; Region: PRD; pfam00874 220668008948 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 220668008949 active site 220668008950 phosphorylation site [posttranslational modification] 220668008951 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 220668008952 classical (c) SDRs; Region: SDR_c; cd05233 220668008953 NAD(P) binding site [chemical binding]; other site 220668008954 active site 220668008955 Transcriptional regulators [Transcription]; Region: PurR; COG1609 220668008956 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 220668008957 DNA binding site [nucleotide binding] 220668008958 domain linker motif; other site 220668008959 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 220668008960 dimerization interface [polypeptide binding]; other site 220668008961 ligand binding site [chemical binding]; other site 220668008962 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 220668008963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 220668008964 putative substrate translocation pore; other site 220668008965 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 220668008966 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 220668008967 Ca binding site [ion binding]; other site 220668008968 active site 220668008969 catalytic site [active] 220668008970 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 220668008971 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 220668008972 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 220668008973 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 220668008974 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 220668008975 nucleotide binding site [chemical binding]; other site 220668008976 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 220668008977 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 220668008978 active site 220668008979 metal binding site [ion binding]; metal-binding site 220668008980 homodimer interface [polypeptide binding]; other site 220668008981 catalytic site [active] 220668008982 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 220668008983 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 220668008984 Protein of unknown function (DUF1237); Region: DUF1237; cl19841 220668008985 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668008986 DNA-binding site [nucleotide binding]; DNA binding site 220668008987 Transcriptional regulators [Transcription]; Region: PurR; COG1609 220668008988 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 220668008989 ligand binding site [chemical binding]; other site 220668008990 dimerization interface [polypeptide binding]; other site 220668008991 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 220668008992 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 220668008993 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 220668008994 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 220668008995 Walker A/P-loop; other site 220668008996 ATP binding site [chemical binding]; other site 220668008997 Q-loop/lid; other site 220668008998 ABC transporter signature motif; other site 220668008999 Walker B; other site 220668009000 D-loop; other site 220668009001 H-loop/switch region; other site 220668009002 TOBE domain; Region: TOBE_2; pfam08402 220668009003 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 220668009004 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 220668009005 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 220668009006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 220668009007 active site 220668009008 phosphorylation site [posttranslational modification] 220668009009 intermolecular recognition site; other site 220668009010 dimerization interface [polypeptide binding]; other site 220668009011 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 220668009012 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 220668009013 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 220668009014 dimerization interface [polypeptide binding]; other site 220668009015 Histidine kinase; Region: His_kinase; pfam06580 220668009016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 220668009017 ATP binding site [chemical binding]; other site 220668009018 Mg2+ binding site [ion binding]; other site 220668009019 G-X-G motif; other site 220668009020 Protein of unknown function, DUF624; Region: DUF624; cl02369 220668009021 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 220668009022 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 220668009023 Ca binding site [ion binding]; other site 220668009024 active site 220668009025 catalytic site [active] 220668009026 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 220668009027 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 220668009028 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 220668009029 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 220668009030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668009031 dimer interface [polypeptide binding]; other site 220668009032 conserved gate region; other site 220668009033 putative PBP binding loops; other site 220668009034 ABC-ATPase subunit interface; other site 220668009035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 220668009036 dimer interface [polypeptide binding]; other site 220668009037 putative PBP binding loops; other site 220668009038 ABC-ATPase subunit interface; other site 220668009039 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 220668009040 putative active site [active] 220668009041 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 220668009042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 220668009043 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 220668009044 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 220668009045 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 220668009046 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 220668009047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668009048 Walker A/P-loop; other site 220668009049 ATP binding site [chemical binding]; other site 220668009050 Q-loop/lid; other site 220668009051 ABC transporter signature motif; other site 220668009052 Walker B; other site 220668009053 D-loop; other site 220668009054 H-loop/switch region; other site 220668009055 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 220668009056 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 220668009057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 220668009058 Walker A/P-loop; other site 220668009059 ATP binding site [chemical binding]; other site 220668009060 Q-loop/lid; other site 220668009061 ABC transporter signature motif; other site 220668009062 Walker B; other site 220668009063 D-loop; other site 220668009064 H-loop/switch region; other site 220668009065 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 220668009066 DNA-binding site [nucleotide binding]; DNA binding site 220668009067 Transcriptional regulators [Transcription]; Region: PurR; COG1609 220668009068 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 220668009069 ligand binding site [chemical binding]; other site 220668009070 dimerization interface [polypeptide binding]; other site 220668009071 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 220668009072 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 220668009073 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 220668009074 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 220668009075 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 220668009076 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 220668009077 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 220668009078 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 220668009079 ATP synthase complex subunit h; Region: ATP_sub_h; pfam10775 220668009080 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 220668009081 HTH domain; Region: HTH_11; pfam08279 220668009082 PRD domain; Region: PRD; pfam00874 220668009083 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 220668009084 active site 220668009085 phosphorylation site [posttranslational modification] 220668009086 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 220668009087 classical (c) SDRs; Region: SDR_c; cd05233 220668009088 NAD(P) binding site [chemical binding]; other site 220668009089 active site 220668009090 Sugar transport protein; Region: Sugar_transport; pfam06800 220668009091 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 220668009092 D-ribose pyranase; Provisional; Region: PRK11797 220668009093 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 220668009094 substrate binding site [chemical binding]; other site 220668009095 dimer interface [polypeptide binding]; other site 220668009096 ATP binding site [chemical binding]; other site 220668009097 Transcriptional regulators [Transcription]; Region: PurR; COG1609 220668009098 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 220668009099 DNA binding site [nucleotide binding] 220668009100 domain linker motif; other site 220668009101 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 220668009102 dimerization interface [polypeptide binding]; other site 220668009103 ligand binding site [chemical binding]; other site 220668009104 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 220668009105 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 220668009106 putative catalytic cysteine [active] 220668009107 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 220668009108 putative active site [active] 220668009109 metal binding site [ion binding]; metal-binding site 220668009110 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 220668009111 Ligand Binding Site [chemical binding]; other site 220668009112 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 220668009113 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 220668009114 Phenolic Acid Decarboxylase; Region: PAD; cd14241 220668009115 active site 220668009116 dimer interface [polypeptide binding]; other site 220668009117 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 220668009118 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 220668009119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 220668009120 Coenzyme A binding pocket [chemical binding]; other site 220668009121 EDD domain protein, DegV family; Region: DegV; TIGR00762 220668009122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 220668009123 non-specific DNA binding site [nucleotide binding]; other site 220668009124 salt bridge; other site 220668009125 sequence-specific DNA binding site [nucleotide binding]; other site 220668009126 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 220668009127 trimer interface [polypeptide binding]; other site 220668009128 active site 220668009129 G bulge; other site 220668009130 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 220668009131 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 220668009132 Catalytic site [active] 220668009133 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 220668009134 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 220668009135 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 220668009136 WxL domain surface cell wall-binding; Region: WxL; pfam13731 220668009137 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 220668009138 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 220668009139 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 220668009140 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 220668009141 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 220668009142 trmE is a tRNA modification GTPase; Region: trmE; cd04164 220668009143 G1 box; other site 220668009144 GTP/Mg2+ binding site [chemical binding]; other site 220668009145 Switch I region; other site 220668009146 G2 box; other site 220668009147 Switch II region; other site 220668009148 G3 box; other site 220668009149 G4 box; other site 220668009150 G5 box; other site 220668009151 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 220668009152 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 220668009153 Jag N-terminus; Region: Jag_N; pfam14804 220668009154 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 220668009155 G-X-X-G motif; other site 220668009156 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 220668009157 RxxxH motif; other site 220668009158 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 220668009159 Amidohydrolase; Region: Amidohydro_4; pfam13147 220668009160 active site 220668009161 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 220668009162 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 220668009163 peptide binding site [polypeptide binding]; other site 220668009164 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 220668009165 ribonuclease P; Reviewed; Region: rnpA; PRK00499 220668009166 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 220668009167 Replication protein; Region: Rep_1; pfam01446 220668009168 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 220668009169 Plasmid replication protein; Region: Rep_2; pfam01719 220668009170 RelB antitoxin; Region: RelB; cl01171 220668009171 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 220668009172 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 220668009173 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 220668009174 P-loop; other site 220668009175 Magnesium ion binding site [ion binding]; other site 220668009176 multiple promoter invertase; Provisional; Region: mpi; PRK13413 220668009177 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 220668009178 catalytic residues [active] 220668009179 catalytic nucleophile [active] 220668009180 Presynaptic Site I dimer interface [polypeptide binding]; other site 220668009181 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 220668009182 Synaptic Flat tetramer interface [polypeptide binding]; other site 220668009183 Synaptic Site I dimer interface [polypeptide binding]; other site 220668009184 DNA binding site [nucleotide binding] 220668009185 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 220668009186 DNA-binding interface [nucleotide binding]; DNA binding site 220668009187 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 220668009188 dimerization interface [polypeptide binding]; other site 220668009189 putative DNA binding site [nucleotide binding]; other site 220668009190 putative Zn2+ binding site [ion binding]; other site 220668009191 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 220668009192 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 220668009193 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 220668009194 P loop; other site 220668009195 Nucleotide binding site [chemical binding]; other site 220668009196 DTAP/Switch II; other site 220668009197 Switch I; other site 220668009198 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 220668009199 P loop; other site 220668009200 Nucleotide binding site [chemical binding]; other site 220668009201 DTAP/Switch II; other site 220668009202 Switch I; other site 220668009203 Citrate transporter; Region: CitMHS; pfam03600 220668009204 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 220668009205 transmembrane helices; other site 220668009206 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 220668009207 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 220668009208 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 220668009209 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 220668009210 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 220668009211 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 220668009212 dimerization interface [polypeptide binding]; other site 220668009213 putative DNA binding site [nucleotide binding]; other site 220668009214 putative Zn2+ binding site [ion binding]; other site 220668009215 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 220668009216 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 220668009217 Helix-turn-helix domain; Region: HTH_38; pfam13936 220668009218 Integrase core domain; Region: rve; pfam00665 220668009219 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 220668009220 DNA topoisomerase III; Provisional; Region: PRK07726 220668009221 active site 220668009222 putative interdomain interaction site [polypeptide binding]; other site 220668009223 putative metal-binding site [ion binding]; other site 220668009224 putative nucleotide binding site [chemical binding]; other site 220668009225 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 220668009226 domain I; other site 220668009227 DNA binding groove [nucleotide binding] 220668009228 phosphate binding site [ion binding]; other site 220668009229 domain II; other site 220668009230 domain III; other site 220668009231 nucleotide binding site [chemical binding]; other site 220668009232 catalytic site [active] 220668009233 domain IV; other site 220668009234 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 220668009235 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 220668009236 Walker A motif; other site 220668009237 ATP binding site [chemical binding]; other site 220668009238 Walker B motif; other site 220668009239 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 220668009240 catalytic residues [active] 220668009241 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 220668009242 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 220668009243 catalytic residue [active] 220668009244 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 220668009245 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 220668009246 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 220668009247 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 220668009248 Domain of unknown function DUF87; Region: DUF87; cl19135 220668009249 AAA-like domain; Region: AAA_10; pfam12846 220668009250 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 220668009251 G1 box; other site 220668009252 GTP/Mg2+ binding site [chemical binding]; other site 220668009253 Switch I region; other site 220668009254 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 220668009255 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 220668009256 MobA/MobL family; Region: MobA_MobL; pfam03389 220668009257 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 220668009258 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 220668009259 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 220668009260 catalytic residues [active] 220668009261 catalytic nucleophile [active] 220668009262 Presynaptic Site I dimer interface [polypeptide binding]; other site 220668009263 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 220668009264 Synaptic Flat tetramer interface [polypeptide binding]; other site 220668009265 Synaptic Site I dimer interface [polypeptide binding]; other site 220668009266 DNA binding site [nucleotide binding] 220668009267 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 220668009268 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526