-- dump date   	20140619_124256
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1284663000001	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1284663000002	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1284663000003	dimer interface [polypeptide binding]; other site
1284663000004	active site
1284663000005	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1284663000006	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1284663000007	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1284663000008	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1284663000009	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1284663000010	tetramer interfaces [polypeptide binding]; other site
1284663000011	binuclear metal-binding site [ion binding]; other site
1284663000012	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663000013	NmrA-like family; Region: NmrA; pfam05368
1284663000014	NAD(P) binding site [chemical binding]; other site
1284663000015	active site
1284663000016	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1284663000017	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1284663000018	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1284663000019	ArsC family; Region: ArsC; pfam03960
1284663000020	putative catalytic residues [active]
1284663000021	thiol/disulfide switch; other site
1284663000022	Uncharacterized conserved protein [Function unknown]; Region: COG3189
1284663000023	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1284663000024	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1284663000025	minor groove reading motif; other site
1284663000026	helix-hairpin-helix signature motif; other site
1284663000027	substrate binding pocket [chemical binding]; other site
1284663000028	active site
1284663000029	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1284663000030	DNA binding and oxoG recognition site [nucleotide binding]
1284663000031	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1284663000032	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
1284663000033	putative dimer interface [polypeptide binding]; other site
1284663000034	atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267
1284663000035	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1284663000036	putative NAD(P) binding site [chemical binding]; other site
1284663000037	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1284663000038	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663000039	Coenzyme A binding pocket [chemical binding]; other site
1284663000040	EamA-like transporter family; Region: EamA; pfam00892
1284663000041	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1284663000042	EamA-like transporter family; Region: EamA; pfam00892
1284663000043	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
1284663000044	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
1284663000045	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1284663000046	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
1284663000047	active site
1284663000048	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1284663000049	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1284663000050	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663000051	motif II; other site
1284663000052	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
1284663000053	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1284663000054	zinc-finger; Region: zf-RING_3; pfam14369
1284663000055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663000056	putative substrate translocation pore; other site
1284663000057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663000058	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1284663000059	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1284663000060	Na binding site [ion binding]; other site
1284663000061	drug efflux system protein MdtG; Provisional; Region: PRK09874
1284663000062	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663000063	putative substrate translocation pore; other site
1284663000064	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1284663000065	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1284663000066	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
1284663000067	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
1284663000068	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1284663000069	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1284663000070	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1284663000071	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1284663000072	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663000073	active site
1284663000074	motif I; other site
1284663000075	motif II; other site
1284663000076	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1284663000077	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1284663000078	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1284663000079	active site
1284663000080	metal binding site [ion binding]; metal-binding site
1284663000081	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1284663000082	Membrane transport protein; Region: Mem_trans; cl09117
1284663000083	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1284663000084	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1284663000085	active site
1284663000086	catalytic tetrad [active]
1284663000087	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1284663000088	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1284663000089	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
1284663000090	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
1284663000091	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1284663000092	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
1284663000093	putative ADP-ribose binding site [chemical binding]; other site
1284663000094	putative active site [active]
1284663000095	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663000096	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663000097	Predicted secreted protein [Function unknown]; Region: COG4086
1284663000098	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
1284663000099	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1284663000100	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1284663000101	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1284663000102	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1284663000103	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1284663000104	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1284663000105	MarR family; Region: MarR_2; pfam12802
1284663000106	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663000107	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663000108	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
1284663000109	active site
1284663000110	nucleotide-binding site [chemical binding]; other site
1284663000111	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
1284663000112	non-specific DNA binding site [nucleotide binding]; other site
1284663000113	salt bridge; other site
1284663000114	sequence-specific DNA binding site [nucleotide binding]; other site
1284663000115	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
1284663000116	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
1284663000117	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663000118	catalytic residue [active]
1284663000119	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1284663000120	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1284663000121	NlpC/P60 family; Region: NLPC_P60; pfam00877
1284663000122	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663000123	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
1284663000124	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
1284663000125	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1284663000126	S-adenosylmethionine binding site [chemical binding]; other site
1284663000127	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1284663000128	putative active site [active]
1284663000129	Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831
1284663000130	active site
1284663000131	catalytic triad [active]
1284663000132	oxyanion hole [active]
1284663000133	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1284663000134	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1284663000135	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1284663000136	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1284663000137	amphipathic channel; other site
1284663000138	Asn-Pro-Ala signature motifs; other site
1284663000139	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1284663000140	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1284663000141	catalytic residues [active]
1284663000142	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
1284663000143	putative homodimer interface [polypeptide binding]; other site
1284663000144	putative homotetramer interface [polypeptide binding]; other site
1284663000145	putative metal binding site [ion binding]; other site
1284663000146	putative homodimer-homodimer interface [polypeptide binding]; other site
1284663000147	putative allosteric switch controlling residues; other site
1284663000148	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1284663000149	Ferritin-like domain; Region: Ferritin; pfam00210
1284663000150	dimerization interface [polypeptide binding]; other site
1284663000151	DPS ferroxidase diiron center [ion binding]; other site
1284663000152	ion pore; other site
1284663000153	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1284663000154	metal-binding site [ion binding]
1284663000155	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1284663000156	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1284663000157	ligand binding site [chemical binding]; other site
1284663000158	flexible hinge region; other site
1284663000159	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1284663000160	non-specific DNA interactions [nucleotide binding]; other site
1284663000161	DNA binding site [nucleotide binding]
1284663000162	sequence specific DNA binding site [nucleotide binding]; other site
1284663000163	putative cAMP binding site [chemical binding]; other site
1284663000164	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1284663000165	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1284663000166	active site
1284663000167	Zn binding site [ion binding]; other site
1284663000168	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
1284663000169	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1284663000170	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1284663000171	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1284663000172	legume lectins; Region: lectin_L-type; cl14058
1284663000173	homotetramer interaction site [polypeptide binding]; other site
1284663000174	carbohydrate binding site [chemical binding]; other site
1284663000175	metal binding site [ion binding]; metal-binding site
1284663000176	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1284663000177	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1284663000178	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1284663000179	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1284663000180	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1284663000181	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663000182	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663000183	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
1284663000184	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1284663000185	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663000186	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1284663000187	Walker A motif; other site
1284663000188	ATP binding site [chemical binding]; other site
1284663000189	Walker B motif; other site
1284663000190	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
1284663000191	amphipathic channel; other site
1284663000192	Asn-Pro-Ala signature motifs; other site
1284663000193	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1284663000194	ABC1 family; Region: ABC1; cl17513
1284663000195	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
1284663000196	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1284663000197	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1284663000198	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1284663000199	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1284663000200	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1284663000201	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1284663000202	Melibiase; Region: Melibiase; pfam02065
1284663000203	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1284663000204	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1284663000205	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1284663000206	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1284663000207	DNA binding site [nucleotide binding]
1284663000208	domain linker motif; other site
1284663000209	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1284663000210	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1284663000211	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663000212	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663000213	putative substrate translocation pore; other site
1284663000214	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1284663000215	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663000216	putative substrate translocation pore; other site
1284663000217	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663000218	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1284663000219	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1284663000220	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1284663000221	Fic/DOC family; Region: Fic; cl00960
1284663000222	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663000223	non-specific DNA binding site [nucleotide binding]; other site
1284663000224	salt bridge; other site
1284663000225	sequence-specific DNA binding site [nucleotide binding]; other site
1284663000226	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
1284663000227	FIC domain binding interface [polypeptide binding]; other site
1284663000228	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
1284663000229	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1284663000230	DNA binding site [nucleotide binding]
1284663000231	domain linker motif; other site
1284663000232	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
1284663000233	putative dimerization interface [polypeptide binding]; other site
1284663000234	putative ligand binding site [chemical binding]; other site
1284663000235	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
1284663000236	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
1284663000237	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
1284663000238	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1284663000239	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1284663000240	NAD binding site [chemical binding]; other site
1284663000241	homodimer interface [polypeptide binding]; other site
1284663000242	active site
1284663000243	substrate binding site [chemical binding]; other site
1284663000244	galactokinase; Provisional; Region: PRK05322
1284663000245	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1284663000246	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1284663000247	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1284663000248	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1284663000249	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1284663000250	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1284663000251	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
1284663000252	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1284663000253	Melibiase; Region: Melibiase; pfam02065
1284663000254	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
1284663000255	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663000256	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
1284663000257	HPr interaction site; other site
1284663000258	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1284663000259	active site
1284663000260	phosphorylation site [posttranslational modification]
1284663000261	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1284663000262	active site
1284663000263	catalytic residues [active]
1284663000264	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
1284663000265	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1284663000266	DNA binding site [nucleotide binding]
1284663000267	domain linker motif; other site
1284663000268	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
1284663000269	putative dimerization interface [polypeptide binding]; other site
1284663000270	putative ligand binding site [chemical binding]; other site
1284663000271	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1284663000272	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1284663000273	active site
1284663000274	catalytic tetrad [active]
1284663000275	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1284663000276	FMN-binding domain; Region: FMN_bind; cl01081
1284663000277	L-aspartate oxidase; Provisional; Region: PRK06175
1284663000278	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
1284663000279	Predicted flavoprotein [General function prediction only]; Region: COG0431
1284663000280	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1284663000281	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1284663000282	ApbE family; Region: ApbE; pfam02424
1284663000283	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1284663000284	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1284663000285	active site
1284663000286	catalytic residue [active]
1284663000287	dimer interface [polypeptide binding]; other site
1284663000288	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
1284663000289	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1284663000290	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1284663000291	shikimate binding site; other site
1284663000292	NAD(P) binding site [chemical binding]; other site
1284663000293	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663000294	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663000295	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1284663000296	putative dimerization interface [polypeptide binding]; other site
1284663000297	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663000298	putative substrate translocation pore; other site
1284663000299	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
1284663000300	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1284663000301	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1284663000302	shikimate binding site; other site
1284663000303	NAD(P) binding site [chemical binding]; other site
1284663000304	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
1284663000305	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1284663000306	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1284663000307	shikimate binding site; other site
1284663000308	NAD(P) binding site [chemical binding]; other site
1284663000309	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1284663000310	classical (c) SDRs; Region: SDR_c; cd05233
1284663000311	NAD(P) binding site [chemical binding]; other site
1284663000312	active site
1284663000313	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1284663000314	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663000315	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663000316	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1284663000317	putative dimerization interface [polypeptide binding]; other site
1284663000318	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663000319	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663000320	putative substrate translocation pore; other site
1284663000321	Putative esterase; Region: Esterase; pfam00756
1284663000322	S-formylglutathione hydrolase; Region: PLN02442
1284663000323	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
1284663000324	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1284663000325	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1284663000326	DNA-binding site [nucleotide binding]; DNA binding site
1284663000327	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1284663000328	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1284663000329	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1284663000330	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570
1284663000331	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1284663000332	putative active site [active]
1284663000333	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1284663000334	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1284663000335	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1284663000336	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1284663000337	beta-galactosidase; Region: BGL; TIGR03356
1284663000338	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
1284663000339	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1284663000340	active site turn [active]
1284663000341	phosphorylation site [posttranslational modification]
1284663000342	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1284663000343	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1284663000344	HPr interaction site; other site
1284663000345	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1284663000346	active site
1284663000347	phosphorylation site [posttranslational modification]
1284663000348	PRD domain; Region: PRD; pfam00874
1284663000349	PRD domain; Region: PRD; pfam00874
1284663000350	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1284663000351	beta-galactosidase; Region: BGL; TIGR03356
1284663000352	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1284663000353	beta-galactosidase; Region: BGL; TIGR03356
1284663000354	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
1284663000355	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1284663000356	active site turn [active]
1284663000357	phosphorylation site [posttranslational modification]
1284663000358	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1284663000359	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1284663000360	HPr interaction site; other site
1284663000361	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1284663000362	active site
1284663000363	phosphorylation site [posttranslational modification]
1284663000364	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1284663000365	CAT RNA binding domain; Region: CAT_RBD; smart01061
1284663000366	PRD domain; Region: PRD; pfam00874
1284663000367	PRD domain; Region: PRD; pfam00874
1284663000368	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
1284663000369	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1284663000370	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1284663000371	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
1284663000372	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1284663000373	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1284663000374	DNA binding site [nucleotide binding]
1284663000375	domain linker motif; other site
1284663000376	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1284663000377	dimerization interface [polypeptide binding]; other site
1284663000378	ligand binding site [chemical binding]; other site
1284663000379	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663000380	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663000381	putative substrate translocation pore; other site
1284663000382	putative alpha-glucosidase; Provisional; Region: PRK10658
1284663000383	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1284663000384	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
1284663000385	trimer interface [polypeptide binding]; other site
1284663000386	active site
1284663000387	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
1284663000388	catalytic site [active]
1284663000389	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1284663000390	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
1284663000391	active site
1284663000392	sugar phosphate phosphatase; Provisional; Region: PRK10513
1284663000393	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663000394	active site
1284663000395	motif I; other site
1284663000396	motif II; other site
1284663000397	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1284663000398	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1284663000399	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1284663000400	TPP-binding site [chemical binding]; other site
1284663000401	dimer interface [polypeptide binding]; other site
1284663000402	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1284663000403	PYR/PP interface [polypeptide binding]; other site
1284663000404	dimer interface [polypeptide binding]; other site
1284663000405	TPP binding site [chemical binding]; other site
1284663000406	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1284663000407	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1284663000408	active site
1284663000409	intersubunit interactions; other site
1284663000410	catalytic residue [active]
1284663000411	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1284663000412	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1284663000413	active site
1284663000414	P-loop; other site
1284663000415	phosphorylation site [posttranslational modification]
1284663000416	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1284663000417	active site
1284663000418	phosphorylation site [posttranslational modification]
1284663000419	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1284663000420	PRD domain; Region: PRD; pfam00874
1284663000421	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1284663000422	active site
1284663000423	P-loop; other site
1284663000424	phosphorylation site [posttranslational modification]
1284663000425	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1284663000426	active site
1284663000427	phosphorylation site [posttranslational modification]
1284663000428	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1284663000429	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663000430	motif II; other site
1284663000431	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1284663000432	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
1284663000433	putative NAD(P) binding site [chemical binding]; other site
1284663000434	catalytic Zn binding site [ion binding]; other site
1284663000435	structural Zn binding site [ion binding]; other site
1284663000436	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
1284663000437	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
1284663000438	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
1284663000439	active site
1284663000440	P-loop; other site
1284663000441	phosphorylation site [posttranslational modification]
1284663000442	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1284663000443	active site
1284663000444	phosphorylation site [posttranslational modification]
1284663000445	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1284663000446	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1284663000447	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1284663000448	putative phosphoketolase; Provisional; Region: PRK05261
1284663000449	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
1284663000450	TPP-binding site; other site
1284663000451	XFP C-terminal domain; Region: XFP_C; pfam09363
1284663000452	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1284663000453	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1284663000454	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1284663000455	putative active site [active]
1284663000456	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
1284663000457	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1284663000458	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1284663000459	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1284663000460	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1284663000461	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
1284663000462	Na binding site [ion binding]; other site
1284663000463	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1284663000464	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1284663000465	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1284663000466	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1284663000467	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1284663000468	nucleotide binding site [chemical binding]; other site
1284663000469	N-acetylneuraminate lyase; Provisional; Region: PRK04147
1284663000470	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
1284663000471	inhibitor site; inhibition site
1284663000472	active site
1284663000473	dimer interface [polypeptide binding]; other site
1284663000474	catalytic residue [active]
1284663000475	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1284663000476	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
1284663000477	putative active site cavity [active]
1284663000478	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1284663000479	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1284663000480	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1284663000481	conserved hypothetical protein; Region: TIGR02328
1284663000482	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
1284663000483	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1284663000484	Predicted membrane protein [Function unknown]; Region: COG2261
1284663000485	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1284663000486	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
1284663000487	heme binding pocket [chemical binding]; other site
1284663000488	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1284663000489	ArsC family; Region: ArsC; pfam03960
1284663000490	putative catalytic residues [active]
1284663000491	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1284663000492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1284663000493	active site
1284663000494	phosphorylation site [posttranslational modification]
1284663000495	intermolecular recognition site; other site
1284663000496	dimerization interface [polypeptide binding]; other site
1284663000497	LytTr DNA-binding domain; Region: LytTR; pfam04397
1284663000498	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1284663000499	Accessory gene regulator B; Region: AgrB; smart00793
1284663000500	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663000501	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1284663000502	Walker A motif; other site
1284663000503	ATP binding site [chemical binding]; other site
1284663000504	Walker B motif; other site
1284663000505	arginine finger; other site
1284663000506	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663000507	Walker A motif; other site
1284663000508	ATP binding site [chemical binding]; other site
1284663000509	Walker B motif; other site
1284663000510	arginine finger; other site
1284663000511	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1284663000512	L-lactate oxidase; Region: L_lactate_ox; TIGR02708
1284663000513	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
1284663000514	teramer interface [polypeptide binding]; other site
1284663000515	active site
1284663000516	FMN binding site [chemical binding]; other site
1284663000517	catalytic residues [active]
1284663000518	pyruvate oxidase; Provisional; Region: PRK08611
1284663000519	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1284663000520	PYR/PP interface [polypeptide binding]; other site
1284663000521	dimer interface [polypeptide binding]; other site
1284663000522	tetramer interface [polypeptide binding]; other site
1284663000523	TPP binding site [chemical binding]; other site
1284663000524	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1284663000525	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1284663000526	TPP-binding site [chemical binding]; other site
1284663000527	Transcriptional regulator; Region: Rrf2; pfam02082
1284663000528	Rrf2 family protein; Region: rrf2_super; TIGR00738
1284663000529	Transcriptional regulator; Region: Rrf2; cl17282
1284663000530	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
1284663000531	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1284663000532	PYR/PP interface [polypeptide binding]; other site
1284663000533	dimer interface [polypeptide binding]; other site
1284663000534	tetramer interface [polypeptide binding]; other site
1284663000535	TPP binding site [chemical binding]; other site
1284663000536	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1284663000537	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1284663000538	TPP-binding site [chemical binding]; other site
1284663000539	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
1284663000540	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
1284663000541	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
1284663000542	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
1284663000543	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
1284663000544	Glucitol operon activator protein (GutM); Region: GutM; pfam06923
1284663000545	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1284663000546	HTH domain; Region: HTH_11; pfam08279
1284663000547	PRD domain; Region: PRD; pfam00874
1284663000548	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
1284663000549	active site
1284663000550	phosphorylation site [posttranslational modification]
1284663000551	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
1284663000552	classical (c) SDRs; Region: SDR_c; cd05233
1284663000553	NAD(P) binding site [chemical binding]; other site
1284663000554	active site
1284663000555	Sugar transport protein; Region: Sugar_transport; pfam06800
1284663000556	D-ribose pyranase; Provisional; Region: PRK11797
1284663000557	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1284663000558	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1284663000559	substrate binding site [chemical binding]; other site
1284663000560	dimer interface [polypeptide binding]; other site
1284663000561	ATP binding site [chemical binding]; other site
1284663000562	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1284663000563	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1284663000564	DNA binding site [nucleotide binding]
1284663000565	domain linker motif; other site
1284663000566	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1284663000567	dimerization interface [polypeptide binding]; other site
1284663000568	ligand binding site [chemical binding]; other site
1284663000569	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1284663000570	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1284663000571	putative catalytic cysteine [active]
1284663000572	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1284663000573	putative active site [active]
1284663000574	metal binding site [ion binding]; metal-binding site
1284663000575	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1284663000576	Ligand Binding Site [chemical binding]; other site
1284663000577	Predicted transcriptional regulators [Transcription]; Region: COG1695
1284663000578	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1284663000579	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1284663000580	Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870
1284663000581	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1284663000582	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1284663000583	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663000584	Coenzyme A binding pocket [chemical binding]; other site
1284663000585	EDD domain protein, DegV family; Region: DegV; TIGR00762
1284663000586	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1284663000587	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663000588	non-specific DNA binding site [nucleotide binding]; other site
1284663000589	salt bridge; other site
1284663000590	sequence-specific DNA binding site [nucleotide binding]; other site
1284663000591	potential frameshift: common BLAST hit: pepC2
1284663000592	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298
1284663000593	active site
1284663000594	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
1284663000595	trimer interface [polypeptide binding]; other site
1284663000596	active site
1284663000597	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1284663000598	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
1284663000599	Catalytic site [active]
1284663000600	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1284663000601	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1284663000602	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1284663000603	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1284663000604	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1284663000605	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1284663000606	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1284663000607	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1284663000608	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1284663000609	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1284663000610	G1 box; other site
1284663000611	GTP/Mg2+ binding site [chemical binding]; other site
1284663000612	Switch I region; other site
1284663000613	G2 box; other site
1284663000614	Switch II region; other site
1284663000615	G3 box; other site
1284663000616	G4 box; other site
1284663000617	G5 box; other site
1284663000618	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1284663000619	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1284663000620	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1284663000621	G-X-X-G motif; other site
1284663000622	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1284663000623	RxxxH motif; other site
1284663000624	potential frameshift: common BLAST hit: Amidohydrolase family protein
1284663000625	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1284663000626	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1284663000627	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
1284663000628	active site
1284663000629	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1284663000630	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1284663000631	peptide binding site [polypeptide binding]; other site
1284663000632	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1284663000633	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
1284663000634	ribonuclease P; Reviewed; Region: rnpA; PRK00499
1284663000635	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1284663000636	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1284663000637	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663000638	Walker A motif; other site
1284663000639	ATP binding site [chemical binding]; other site
1284663000640	Walker B motif; other site
1284663000641	arginine finger; other site
1284663000642	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1284663000643	DnaA box-binding interface [nucleotide binding]; other site
1284663000644	DNA polymerase III subunit beta; Validated; Region: PRK05643
1284663000645	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1284663000646	putative DNA binding surface [nucleotide binding]; other site
1284663000647	dimer interface [polypeptide binding]; other site
1284663000648	beta-clamp/clamp loader binding surface; other site
1284663000649	beta-clamp/translesion DNA polymerase binding surface; other site
1284663000650	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
1284663000651	recombination protein F; Reviewed; Region: recF; PRK00064
1284663000652	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1284663000653	Walker A/P-loop; other site
1284663000654	ATP binding site [chemical binding]; other site
1284663000655	Q-loop/lid; other site
1284663000656	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663000657	ABC transporter signature motif; other site
1284663000658	Walker B; other site
1284663000659	D-loop; other site
1284663000660	H-loop/switch region; other site
1284663000661	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1284663000662	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1284663000663	Mg2+ binding site [ion binding]; other site
1284663000664	G-X-G motif; other site
1284663000665	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1284663000666	anchoring element; other site
1284663000667	dimer interface [polypeptide binding]; other site
1284663000668	ATP binding site [chemical binding]; other site
1284663000669	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1284663000670	active site
1284663000671	putative metal-binding site [ion binding]; other site
1284663000672	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1284663000673	DNA gyrase subunit A; Validated; Region: PRK05560
1284663000674	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1284663000675	CAP-like domain; other site
1284663000676	active site
1284663000677	primary dimer interface [polypeptide binding]; other site
1284663000678	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1284663000679	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1284663000680	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1284663000681	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1284663000682	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1284663000683	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1284663000684	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1284663000685	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1284663000686	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1284663000687	dimer interface [polypeptide binding]; other site
1284663000688	ssDNA binding site [nucleotide binding]; other site
1284663000689	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1284663000690	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1284663000691	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
1284663000692	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1284663000693	metal binding site [ion binding]; metal-binding site
1284663000694	DHH family; Region: DHH; pfam01368
1284663000695	DHHA1 domain; Region: DHHA1; pfam02272
1284663000696	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1284663000697	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1284663000698	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1284663000699	replicative DNA helicase; Provisional; Region: PRK05748
1284663000700	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1284663000701	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1284663000702	Walker A motif; other site
1284663000703	ATP binding site [chemical binding]; other site
1284663000704	Walker B motif; other site
1284663000705	DNA binding loops [nucleotide binding]
1284663000706	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663000707	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663000708	putative substrate translocation pore; other site
1284663000709	gamma-glutamyl kinase; Provisional; Region: PRK05429
1284663000710	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1284663000711	nucleotide binding site [chemical binding]; other site
1284663000712	homotetrameric interface [polypeptide binding]; other site
1284663000713	putative phosphate binding site [ion binding]; other site
1284663000714	putative allosteric binding site; other site
1284663000715	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1284663000716	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1284663000717	putative catalytic cysteine [active]
1284663000718	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1284663000719	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1284663000720	peptide binding site [polypeptide binding]; other site
1284663000721	glycogen branching enzyme; Provisional; Region: PRK12313
1284663000722	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1284663000723	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1284663000724	active site
1284663000725	catalytic site [active]
1284663000726	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1284663000727	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
1284663000728	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1284663000729	ligand binding site; other site
1284663000730	oligomer interface; other site
1284663000731	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1284663000732	dimer interface [polypeptide binding]; other site
1284663000733	N-terminal domain interface [polypeptide binding]; other site
1284663000734	sulfate 1 binding site; other site
1284663000735	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
1284663000736	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1284663000737	ligand binding site; other site
1284663000738	oligomer interface; other site
1284663000739	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1284663000740	dimer interface [polypeptide binding]; other site
1284663000741	N-terminal domain interface [polypeptide binding]; other site
1284663000742	sulfate 1 binding site; other site
1284663000743	glycogen synthase; Provisional; Region: glgA; PRK00654
1284663000744	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1284663000745	ADP-binding pocket [chemical binding]; other site
1284663000746	homodimer interface [polypeptide binding]; other site
1284663000747	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1284663000748	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1284663000749	active site pocket [active]
1284663000750	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1284663000751	active site
1284663000752	homodimer interface [polypeptide binding]; other site
1284663000753	catalytic site [active]
1284663000754	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1284663000755	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663000756	active site
1284663000757	motif I; other site
1284663000758	motif II; other site
1284663000759	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1284663000760	beta-phosphoglucomutase; Region: bPGM; TIGR01990
1284663000761	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663000762	motif II; other site
1284663000763	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
1284663000764	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1284663000765	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1284663000766	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
1284663000767	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1284663000768	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1284663000769	DNA-binding site [nucleotide binding]; DNA binding site
1284663000770	RNA-binding motif; other site
1284663000771	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1284663000772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1284663000773	active site
1284663000774	phosphorylation site [posttranslational modification]
1284663000775	intermolecular recognition site; other site
1284663000776	dimerization interface [polypeptide binding]; other site
1284663000777	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1284663000778	DNA binding site [nucleotide binding]
1284663000779	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1284663000780	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1284663000781	dimerization interface [polypeptide binding]; other site
1284663000782	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1284663000783	putative active site [active]
1284663000784	heme pocket [chemical binding]; other site
1284663000785	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1284663000786	dimer interface [polypeptide binding]; other site
1284663000787	phosphorylation site [posttranslational modification]
1284663000788	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1284663000789	ATP binding site [chemical binding]; other site
1284663000790	Mg2+ binding site [ion binding]; other site
1284663000791	G-X-G motif; other site
1284663000792	YycH protein; Region: YycH; pfam07435
1284663000793	YycH protein; Region: YycI; pfam09648
1284663000794	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1284663000795	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1284663000796	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1284663000797	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1284663000798	protein binding site [polypeptide binding]; other site
1284663000799	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1284663000800	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663000801	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1284663000802	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1284663000803	NAD(P) binding site [chemical binding]; other site
1284663000804	catalytic residues [active]
1284663000805	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
1284663000806	Uncharacterized conserved protein [Function unknown]; Region: COG3586
1284663000807	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
1284663000808	putative uracil binding site [chemical binding]; other site
1284663000809	putative active site [active]
1284663000810	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
1284663000811	putative FMN binding site [chemical binding]; other site
1284663000812	6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112
1284663000813	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
1284663000814	Predicted flavoprotein [General function prediction only]; Region: COG0431
1284663000815	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1284663000816	FAD binding domain; Region: FAD_binding_2; pfam00890
1284663000817	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1284663000818	FMN-binding domain; Region: FMN_bind; cl01081
1284663000819	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1284663000820	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1284663000821	transmembrane helices; other site
1284663000822	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663000823	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663000824	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1284663000825	dimerization interface [polypeptide binding]; other site
1284663000826	flavodoxin; Provisional; Region: PRK06242
1284663000827	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1284663000828	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1284663000829	active site
1284663000830	hypothetical protein; Provisional; Region: PRK06194
1284663000831	classical (c) SDRs; Region: SDR_c; cd05233
1284663000832	NAD(P) binding site [chemical binding]; other site
1284663000833	active site
1284663000834	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
1284663000835	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1284663000836	dimer interface [polypeptide binding]; other site
1284663000837	FMN binding site [chemical binding]; other site
1284663000838	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1284663000839	beta-phosphoglucomutase; Region: bPGM; TIGR01990
1284663000840	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663000841	motif II; other site
1284663000842	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1284663000843	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
1284663000844	active site
1284663000845	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1284663000846	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1284663000847	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
1284663000848	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1284663000849	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1284663000850	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309
1284663000851	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
1284663000852	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
1284663000853	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1284663000854	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1284663000855	catalytic triad [active]
1284663000856	Predicted transcriptional regulator [Transcription]; Region: COG2378
1284663000857	HTH domain; Region: HTH_11; pfam08279
1284663000858	WYL domain; Region: WYL; pfam13280
1284663000859	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1284663000860	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
1284663000861	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
1284663000862	G1 box; other site
1284663000863	putative GEF interaction site [polypeptide binding]; other site
1284663000864	GTP/Mg2+ binding site [chemical binding]; other site
1284663000865	Switch I region; other site
1284663000866	G2 box; other site
1284663000867	G3 box; other site
1284663000868	Switch II region; other site
1284663000869	G4 box; other site
1284663000870	G5 box; other site
1284663000871	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
1284663000872	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
1284663000873	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
1284663000874	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
1284663000875	Protein of unknown function; Region: DUF3658; pfam12395
1284663000876	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1284663000877	EamA-like transporter family; Region: EamA; pfam00892
1284663000878	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1284663000879	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663000880	Coenzyme A binding pocket [chemical binding]; other site
1284663000881	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1284663000882	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1284663000883	potential catalytic triad [active]
1284663000884	conserved cys residue [active]
1284663000885	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1284663000886	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1284663000887	putative NAD(P) binding site [chemical binding]; other site
1284663000888	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1284663000889	dimerization interface [polypeptide binding]; other site
1284663000890	putative DNA binding site [nucleotide binding]; other site
1284663000891	putative Zn2+ binding site [ion binding]; other site
1284663000892	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1284663000893	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1284663000894	potential frameshift: common BLAST hit: pepI
1284663000895	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
1284663000896	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1284663000897	hypothetical protein; Validated; Region: PRK02101
1284663000898	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1284663000899	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1284663000900	peptide binding site [polypeptide binding]; other site
1284663000901	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1284663000902	active site
1284663000903	NTP binding site [chemical binding]; other site
1284663000904	metal binding triad [ion binding]; metal-binding site
1284663000905	antibiotic binding site [chemical binding]; other site
1284663000906	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1284663000907	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1284663000908	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1284663000909	Walker A/P-loop; other site
1284663000910	ATP binding site [chemical binding]; other site
1284663000911	Q-loop/lid; other site
1284663000912	ABC transporter signature motif; other site
1284663000913	Walker B; other site
1284663000914	D-loop; other site
1284663000915	H-loop/switch region; other site
1284663000916	Cobalt transport protein; Region: CbiQ; cl00463
1284663000917	cobalt transport protein CbiM; Provisional; Region: PRK07331
1284663000918	cobalt transport protein CbiM; Provisional; Region: PRK11909
1284663000919	PDGLE domain; Region: PDGLE; pfam13190
1284663000920	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1284663000921	putative switch regulator; other site
1284663000922	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1284663000923	non-specific DNA interactions [nucleotide binding]; other site
1284663000924	DNA binding site [nucleotide binding]
1284663000925	sequence specific DNA binding site [nucleotide binding]; other site
1284663000926	putative cAMP binding site [chemical binding]; other site
1284663000927	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
1284663000928	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
1284663000929	AIR carboxylase; Region: AIRC; smart01001
1284663000930	Protein of unknown function DUF111; Region: DUF111; cl03398
1284663000931	Protein of unknown function DUF111; Region: DUF111; cl03398
1284663000932	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1284663000933	amphipathic channel; other site
1284663000934	Asn-Pro-Ala signature motifs; other site
1284663000935	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
1284663000936	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
1284663000937	Ligand Binding Site [chemical binding]; other site
1284663000938	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271
1284663000939	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1284663000940	putative NAD(P) binding site [chemical binding]; other site
1284663000941	substrate binding site [chemical binding]; other site
1284663000942	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1284663000943	substrate binding site [chemical binding]; other site
1284663000944	multimerization interface [polypeptide binding]; other site
1284663000945	ATP binding site [chemical binding]; other site
1284663000946	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1284663000947	dimer interface [polypeptide binding]; other site
1284663000948	substrate binding site [chemical binding]; other site
1284663000949	ATP binding site [chemical binding]; other site
1284663000950	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1284663000951	thiamine phosphate binding site [chemical binding]; other site
1284663000952	active site
1284663000953	pyrophosphate binding site [ion binding]; other site
1284663000954	putative hydroxymethylpyrimidine transporter CytX; Region: thia_cytX; TIGR02358
1284663000955	Na binding site [ion binding]; other site
1284663000956	Peptidase C26; Region: Peptidase_C26; pfam07722
1284663000957	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1284663000958	catalytic triad [active]
1284663000959	The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910
1284663000960	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
1284663000961	nudix motif; other site
1284663000962	putative transport protein YifK; Provisional; Region: PRK10746
1284663000963	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1284663000964	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
1284663000965	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
1284663000966	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
1284663000967	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
1284663000968	CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd12218
1284663000969	CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866
1284663000970	tetramer interface [polypeptide binding]; other site
1284663000971	putative DNA binding site [nucleotide binding]; other site
1284663000972	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1284663000973	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1284663000974	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1284663000975	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1284663000976	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1284663000977	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1284663000978	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
1284663000979	PspC domain; Region: PspC; pfam04024
1284663000980	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1284663000981	Predicted flavoprotein [General function prediction only]; Region: COG0431
1284663000982	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1284663000983	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1284663000984	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
1284663000985	putative dimer interface [polypeptide binding]; other site
1284663000986	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
1284663000987	LytTr DNA-binding domain; Region: LytTR; cl04498
1284663000988	drug efflux system protein MdtG; Provisional; Region: PRK09874
1284663000989	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663000990	putative substrate translocation pore; other site
1284663000991	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1284663000992	dimerization interface [polypeptide binding]; other site
1284663000993	putative DNA binding site [nucleotide binding]; other site
1284663000994	putative Zn2+ binding site [ion binding]; other site
1284663000995	potential frameshift: common BLAST hit: Transport protein, major facilitator superfamily (MFS)
1284663000996	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663000997	putative substrate translocation pore; other site
1284663000998	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1284663000999	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1284663001000	active site
1284663001001	catalytic tetrad [active]
1284663001002	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1284663001003	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1284663001004	active site
1284663001005	catalytic tetrad [active]
1284663001006	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
1284663001007	myosin-cross-reactive antigen; Provisional; Region: PRK13977
1284663001008	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1284663001009	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1284663001010	putative active site [active]
1284663001011	putative FMN binding site [chemical binding]; other site
1284663001012	putative substrate binding site [chemical binding]; other site
1284663001013	putative catalytic residue [active]
1284663001014	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1284663001015	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1284663001016	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1284663001017	Walker A/P-loop; other site
1284663001018	ATP binding site [chemical binding]; other site
1284663001019	Q-loop/lid; other site
1284663001020	ABC transporter signature motif; other site
1284663001021	Walker B; other site
1284663001022	D-loop; other site
1284663001023	H-loop/switch region; other site
1284663001024	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
1284663001025	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1284663001026	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1284663001027	Walker A/P-loop; other site
1284663001028	ATP binding site [chemical binding]; other site
1284663001029	Q-loop/lid; other site
1284663001030	ABC transporter signature motif; other site
1284663001031	Walker B; other site
1284663001032	D-loop; other site
1284663001033	H-loop/switch region; other site
1284663001034	hypothetical protein; Provisional; Region: PRK13661
1284663001035	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1284663001036	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1284663001037	DNA-binding site [nucleotide binding]; DNA binding site
1284663001038	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1284663001039	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1284663001040	classical (c) SDRs; Region: SDR_c; cd05233
1284663001041	NAD(P) binding site [chemical binding]; other site
1284663001042	active site
1284663001043	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1284663001044	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1284663001045	Walker A/P-loop; other site
1284663001046	ATP binding site [chemical binding]; other site
1284663001047	Q-loop/lid; other site
1284663001048	ABC transporter signature motif; other site
1284663001049	Walker B; other site
1284663001050	D-loop; other site
1284663001051	H-loop/switch region; other site
1284663001052	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1284663001053	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
1284663001054	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663001055	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663001056	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1284663001057	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1284663001058	active site
1284663001059	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1284663001060	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1284663001061	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663001062	probable dihydroxyacetone kinase DhaK1b subunit; Region: dhaK1b; TIGR02362
1284663001063	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1284663001064	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1284663001065	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1284663001066	DAK2 domain; Region: Dak2; cl03685
1284663001067	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
1284663001068	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1284663001069	amphipathic channel; other site
1284663001070	Asn-Pro-Ala signature motifs; other site
1284663001071	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1284663001072	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1284663001073	DNA binding site [nucleotide binding]
1284663001074	domain linker motif; other site
1284663001075	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
1284663001076	putative dimerization interface [polypeptide binding]; other site
1284663001077	putative ligand binding site [chemical binding]; other site
1284663001078	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1284663001079	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1284663001080	DNA binding site [nucleotide binding]
1284663001081	domain linker motif; other site
1284663001082	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1284663001083	ligand binding site [chemical binding]; other site
1284663001084	dimerization interface [polypeptide binding]; other site
1284663001085	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1284663001086	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1284663001087	Ca binding site [ion binding]; other site
1284663001088	active site
1284663001089	catalytic site [active]
1284663001090	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1284663001091	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1284663001092	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663001093	dimer interface [polypeptide binding]; other site
1284663001094	conserved gate region; other site
1284663001095	putative PBP binding loops; other site
1284663001096	ABC-ATPase subunit interface; other site
1284663001097	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1284663001098	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663001099	dimer interface [polypeptide binding]; other site
1284663001100	conserved gate region; other site
1284663001101	putative PBP binding loops; other site
1284663001102	ABC-ATPase subunit interface; other site
1284663001103	Predicted integral membrane protein [Function unknown]; Region: COG5521
1284663001104	Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313
1284663001105	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1284663001106	active site
1284663001107	catalytic site [active]
1284663001108	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1284663001109	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1284663001110	Walker A/P-loop; other site
1284663001111	ATP binding site [chemical binding]; other site
1284663001112	Q-loop/lid; other site
1284663001113	ABC transporter signature motif; other site
1284663001114	Walker B; other site
1284663001115	D-loop; other site
1284663001116	H-loop/switch region; other site
1284663001117	TOBE domain; Region: TOBE_2; pfam08402
1284663001118	maltose phosphorylase; Provisional; Region: PRK13807
1284663001119	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1284663001120	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1284663001121	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
1284663001122	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1284663001123	Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724
1284663001124	Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins.  The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547
1284663001125	putative active site [active]
1284663001126	FOG: PKD repeat [General function prediction only]; Region: COG3291
1284663001127	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
1284663001128	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1284663001129	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1284663001130	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1284663001131	Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083
1284663001132	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1284663001133	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1284663001134	nucleotide binding site [chemical binding]; other site
1284663001135	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1284663001136	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1284663001137	Melibiase; Region: Melibiase; pfam02065
1284663001138	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1284663001139	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1284663001140	active site turn [active]
1284663001141	phosphorylation site [posttranslational modification]
1284663001142	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1284663001143	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1284663001144	HPr interaction site; other site
1284663001145	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1284663001146	active site
1284663001147	phosphorylation site [posttranslational modification]
1284663001148	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
1284663001149	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1284663001150	substrate binding [chemical binding]; other site
1284663001151	active site
1284663001152	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1284663001153	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1284663001154	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1284663001155	DNA binding site [nucleotide binding]
1284663001156	domain linker motif; other site
1284663001157	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
1284663001158	dimerization interface [polypeptide binding]; other site
1284663001159	ligand binding site [chemical binding]; other site
1284663001160	sodium binding site [ion binding]; other site
1284663001161	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1284663001162	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1284663001163	Ca binding site [ion binding]; other site
1284663001164	active site
1284663001165	catalytic site [active]
1284663001166	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1284663001167	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1284663001168	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1284663001169	putative NAD(P) binding site [chemical binding]; other site
1284663001170	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
1284663001171	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1284663001172	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1284663001173	Ca binding site [ion binding]; other site
1284663001174	active site
1284663001175	catalytic site [active]
1284663001176	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1284663001177	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663001178	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663001179	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1284663001180	dimerization interface [polypeptide binding]; other site
1284663001181	potential frameshift: common BLAST hit: Cell surface protein, LPXTG-motif cell wall anchor
1284663001182	Cna protein B-type domain; Region: Cna_B; pfam05738
1284663001183	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1284663001184	domain interaction interfaces [polypeptide binding]; other site
1284663001185	Cna protein B-type domain; Region: Cna_B; pfam05738
1284663001186	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1284663001187	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663001188	non-specific DNA binding site [nucleotide binding]; other site
1284663001189	salt bridge; other site
1284663001190	sequence-specific DNA binding site [nucleotide binding]; other site
1284663001191	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1284663001192	peptide binding site [polypeptide binding]; other site
1284663001193	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1284663001194	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1284663001195	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1284663001196	peptide binding site [polypeptide binding]; other site
1284663001197	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1284663001198	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1284663001199	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
1284663001200	putative ligand binding site [chemical binding]; other site
1284663001201	putative NAD binding site [chemical binding]; other site
1284663001202	putative catalytic site [active]
1284663001203	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
1284663001204	L-serine binding site [chemical binding]; other site
1284663001205	ACT domain interface; other site
1284663001206	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
1284663001207	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1284663001208	catalytic residue [active]
1284663001209	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1284663001210	catalytic core [active]
1284663001211	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1284663001212	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1284663001213	active site
1284663001214	catalytic tetrad [active]
1284663001215	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
1284663001216	Domain of unknown function (DU1801); Region: DUF1801; cl17490
1284663001217	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1284663001218	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1284663001219	propionate/acetate kinase; Provisional; Region: PRK12379
1284663001220	CrcB-like protein; Region: CRCB; cl09114
1284663001221	CrcB-like protein; Region: CRCB; cl09114
1284663001222	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1284663001223	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1284663001224	ABC transporter; Region: ABC_tran_2; pfam12848
1284663001225	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1284663001226	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1284663001227	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1284663001228	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1284663001229	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1284663001230	Walker A/P-loop; other site
1284663001231	ATP binding site [chemical binding]; other site
1284663001232	Q-loop/lid; other site
1284663001233	ABC transporter signature motif; other site
1284663001234	Walker B; other site
1284663001235	D-loop; other site
1284663001236	H-loop/switch region; other site
1284663001237	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1284663001238	AAA domain; Region: AAA_23; pfam13476
1284663001239	Walker A/P-loop; other site
1284663001240	ATP binding site [chemical binding]; other site
1284663001241	ABC transporter; Region: ABC_tran; pfam00005
1284663001242	Q-loop/lid; other site
1284663001243	ABC transporter signature motif; other site
1284663001244	Walker B; other site
1284663001245	D-loop; other site
1284663001246	H-loop/switch region; other site
1284663001247	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
1284663001248	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1284663001249	catalytic residues [active]
1284663001250	dimer interface [polypeptide binding]; other site
1284663001251	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1284663001252	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1284663001253	active site
1284663001254	catalytic tetrad [active]
1284663001255	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1284663001256	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1284663001257	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1284663001258	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1284663001259	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663001260	non-specific DNA binding site [nucleotide binding]; other site
1284663001261	salt bridge; other site
1284663001262	sequence-specific DNA binding site [nucleotide binding]; other site
1284663001263	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1284663001264	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1284663001265	active site
1284663001266	trimer interface [polypeptide binding]; other site
1284663001267	allosteric site; other site
1284663001268	active site lid [active]
1284663001269	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1284663001270	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663001271	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663001272	putative substrate translocation pore; other site
1284663001273	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
1284663001274	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1284663001275	Predicted oxidoreductase [General function prediction only]; Region: COG3573
1284663001276	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1284663001277	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1284663001278	Peptidase family C69; Region: Peptidase_C69; pfam03577
1284663001279	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
1284663001280	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1284663001281	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1284663001282	active site
1284663001283	P-loop; other site
1284663001284	phosphorylation site [posttranslational modification]
1284663001285	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1284663001286	active site
1284663001287	P-loop; other site
1284663001288	phosphorylation site [posttranslational modification]
1284663001289	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1284663001290	PRD domain; Region: PRD; pfam00874
1284663001291	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1284663001292	active site
1284663001293	P-loop; other site
1284663001294	phosphorylation site [posttranslational modification]
1284663001295	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1284663001296	active site
1284663001297	phosphorylation site [posttranslational modification]
1284663001298	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1284663001299	active site
1284663001300	phosphorylation site [posttranslational modification]
1284663001301	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1284663001302	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1284663001303	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1284663001304	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1284663001305	DNA binding residues [nucleotide binding]
1284663001306	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1284663001307	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1284663001308	catalytic residues [active]
1284663001309	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1284663001310	active site
1284663001311	multimer interface [polypeptide binding]; other site
1284663001312	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
1284663001313	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
1284663001314	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1284663001315	Predicted flavoprotein [General function prediction only]; Region: COG0431
1284663001316	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1284663001317	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1284663001318	DNA-binding site [nucleotide binding]; DNA binding site
1284663001319	UTRA domain; Region: UTRA; pfam07702
1284663001320	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1284663001321	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1284663001322	potential frameshift: common BLAST hit: PTS-associated protein
1284663001323	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1284663001324	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1284663001325	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1284663001326	probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583
1284663001327	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
1284663001328	active site
1284663001329	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
1284663001330	L-seryl-tRNA selenium transferase; Region: SelA; pfam03841
1284663001331	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1284663001332	catalytic residue [active]
1284663001333	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
1284663001334	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1284663001335	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1284663001336	substrate binding site [chemical binding]; other site
1284663001337	ATP binding site [chemical binding]; other site
1284663001338	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1284663001339	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1284663001340	trimer interface [polypeptide binding]; other site
1284663001341	active site
1284663001342	substrate binding site [chemical binding]; other site
1284663001343	CoA binding site [chemical binding]; other site
1284663001344	cystathionine beta-lyase; Provisional; Region: PRK07671
1284663001345	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1284663001346	homodimer interface [polypeptide binding]; other site
1284663001347	substrate-cofactor binding pocket; other site
1284663001348	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663001349	catalytic residue [active]
1284663001350	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1284663001351	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1284663001352	dimer interface [polypeptide binding]; other site
1284663001353	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663001354	catalytic residue [active]
1284663001355	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1284663001356	methionine aminopeptidase; Provisional; Region: PRK08671
1284663001357	active site
1284663001358	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
1284663001359	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
1284663001360	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
1284663001361	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1284663001362	DNA-binding site [nucleotide binding]; DNA binding site
1284663001363	UTRA domain; Region: UTRA; pfam07702
1284663001364	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1284663001365	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1284663001366	Ca binding site [ion binding]; other site
1284663001367	active site
1284663001368	catalytic site [active]
1284663001369	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1284663001370	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1284663001371	HPr interaction site; other site
1284663001372	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1284663001373	active site
1284663001374	phosphorylation site [posttranslational modification]
1284663001375	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1284663001376	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1284663001377	active site turn [active]
1284663001378	phosphorylation site [posttranslational modification]
1284663001379	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1284663001380	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1284663001381	HPr interaction site; other site
1284663001382	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1284663001383	active site
1284663001384	phosphorylation site [posttranslational modification]
1284663001385	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1284663001386	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1284663001387	active site turn [active]
1284663001388	phosphorylation site [posttranslational modification]
1284663001389	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1284663001390	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1284663001391	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
1284663001392	active site
1284663001393	nucleotide binding site [chemical binding]; other site
1284663001394	HIGH motif; other site
1284663001395	KMSKS motif; other site
1284663001396	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1284663001397	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1284663001398	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1284663001399	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1284663001400	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1284663001401	putative ADP-binding pocket [chemical binding]; other site
1284663001402	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1284663001403	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1284663001404	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1284663001405	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1284663001406	Predicted transcriptional regulator [Transcription]; Region: COG1959
1284663001407	Transcriptional regulator; Region: Rrf2; pfam02082
1284663001408	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663001409	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663001410	manganese transport protein MntH; Reviewed; Region: PRK00701
1284663001411	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1284663001412	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1284663001413	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663001414	putative substrate translocation pore; other site
1284663001415	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1284663001416	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1284663001417	DNA binding residues [nucleotide binding]
1284663001418	putative dimer interface [polypeptide binding]; other site
1284663001419	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1284663001420	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1284663001421	dimer interface [polypeptide binding]; other site
1284663001422	phosphorylation site [posttranslational modification]
1284663001423	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1284663001424	ATP binding site [chemical binding]; other site
1284663001425	Mg2+ binding site [ion binding]; other site
1284663001426	G-X-G motif; other site
1284663001427	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1284663001428	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1284663001429	active site
1284663001430	phosphorylation site [posttranslational modification]
1284663001431	intermolecular recognition site; other site
1284663001432	dimerization interface [polypeptide binding]; other site
1284663001433	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1284663001434	DNA binding site [nucleotide binding]
1284663001435	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1284663001436	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1284663001437	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1284663001438	putative active site [active]
1284663001439	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1284663001440	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1284663001441	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1284663001442	FAD binding domain; Region: FAD_binding_4; pfam01565
1284663001443	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1284663001444	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1284663001445	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1284663001446	synthetase active site [active]
1284663001447	NTP binding site [chemical binding]; other site
1284663001448	metal binding site [ion binding]; metal-binding site
1284663001449	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1284663001450	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663001451	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1284663001452	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1284663001453	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1284663001454	Cation efflux family; Region: Cation_efflux; cl00316
1284663001455	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1284663001456	legume lectins; Region: lectin_L-type; cl14058
1284663001457	homotetramer interaction site [polypeptide binding]; other site
1284663001458	carbohydrate binding site [chemical binding]; other site
1284663001459	metal binding site [ion binding]; metal-binding site
1284663001460	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1284663001461	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1284663001462	FtsX-like permease family; Region: FtsX; pfam02687
1284663001463	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1284663001464	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1284663001465	Walker A/P-loop; other site
1284663001466	ATP binding site [chemical binding]; other site
1284663001467	Q-loop/lid; other site
1284663001468	ABC transporter signature motif; other site
1284663001469	Walker B; other site
1284663001470	D-loop; other site
1284663001471	H-loop/switch region; other site
1284663001472	CAAX protease self-immunity; Region: Abi; pfam02517
1284663001473	CAAX protease self-immunity; Region: Abi; pfam02517
1284663001474	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1284663001475	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1284663001476	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1284663001477	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1284663001478	lipoyl attachment site [posttranslational modification]; other site
1284663001479	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1284663001480	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1284663001481	DEAD_2; Region: DEAD_2; pfam06733
1284663001482	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1284663001483	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1284663001484	propionate/acetate kinase; Provisional; Region: PRK12379
1284663001485	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663001486	Coenzyme A binding pocket [chemical binding]; other site
1284663001487	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1284663001488	MarR family; Region: MarR_2; pfam12802
1284663001489	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
1284663001490	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1284663001491	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1284663001492	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1284663001493	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1284663001494	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1284663001495	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663001496	dimer interface [polypeptide binding]; other site
1284663001497	conserved gate region; other site
1284663001498	putative PBP binding loops; other site
1284663001499	ABC-ATPase subunit interface; other site
1284663001500	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1284663001501	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663001502	dimer interface [polypeptide binding]; other site
1284663001503	conserved gate region; other site
1284663001504	putative PBP binding loops; other site
1284663001505	ABC-ATPase subunit interface; other site
1284663001506	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1284663001507	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1284663001508	Walker A/P-loop; other site
1284663001509	ATP binding site [chemical binding]; other site
1284663001510	Q-loop/lid; other site
1284663001511	ABC transporter signature motif; other site
1284663001512	Walker B; other site
1284663001513	D-loop; other site
1284663001514	H-loop/switch region; other site
1284663001515	TOBE domain; Region: TOBE_2; pfam08402
1284663001516	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1284663001517	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663001518	non-specific DNA binding site [nucleotide binding]; other site
1284663001519	salt bridge; other site
1284663001520	sequence-specific DNA binding site [nucleotide binding]; other site
1284663001521	Cupin domain; Region: Cupin_2; pfam07883
1284663001522	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
1284663001523	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663001524	Coenzyme A binding pocket [chemical binding]; other site
1284663001525	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663001526	Coenzyme A binding pocket [chemical binding]; other site
1284663001527	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
1284663001528	Predicted transcriptional regulators [Transcription]; Region: COG1725
1284663001529	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1284663001530	DNA-binding site [nucleotide binding]; DNA binding site
1284663001531	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1284663001532	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1284663001533	Walker A/P-loop; other site
1284663001534	ATP binding site [chemical binding]; other site
1284663001535	Q-loop/lid; other site
1284663001536	ABC transporter signature motif; other site
1284663001537	Walker B; other site
1284663001538	D-loop; other site
1284663001539	H-loop/switch region; other site
1284663001540	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1284663001541	putative catalytic cysteine [active]
1284663001542	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1284663001543	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1284663001544	intersubunit interface [polypeptide binding]; other site
1284663001545	active site
1284663001546	zinc binding site [ion binding]; other site
1284663001547	Na+ binding site [ion binding]; other site
1284663001548	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1284663001549	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
1284663001550	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1284663001551	HflK protein; Region: hflK; TIGR01933
1284663001552	Peptidase family C69; Region: Peptidase_C69; pfam03577
1284663001553	BioY family; Region: BioY; pfam02632
1284663001554	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1284663001555	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
1284663001556	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1284663001557	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1284663001558	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
1284663001559	CHY zinc finger; Region: zf-CHY; pfam05495
1284663001560	transaminase; Reviewed; Region: PRK08068
1284663001561	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1284663001562	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663001563	homodimer interface [polypeptide binding]; other site
1284663001564	catalytic residue [active]
1284663001565	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1284663001566	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1284663001567	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1284663001568	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1284663001569	Walker A/P-loop; other site
1284663001570	ATP binding site [chemical binding]; other site
1284663001571	Q-loop/lid; other site
1284663001572	ABC transporter signature motif; other site
1284663001573	Walker B; other site
1284663001574	D-loop; other site
1284663001575	H-loop/switch region; other site
1284663001576	type II secretion system protein F; Region: GspF; TIGR02120
1284663001577	Predicted transcriptional regulators [Transcription]; Region: COG1695
1284663001578	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1284663001579	potential frameshift: common BLAST hit: Multidrug-efflux transporter, major facilitator superfamily (MFS), EmrB family
1284663001580	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663001581	putative substrate translocation pore; other site
1284663001582	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1284663001583	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1284663001584	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1284663001585	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1284663001586	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
1284663001587	NAD binding site [chemical binding]; other site
1284663001588	dimer interface [polypeptide binding]; other site
1284663001589	substrate binding site [chemical binding]; other site
1284663001590	ATP-dependent protease Lon; Provisional; Region: PRK13765
1284663001591	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
1284663001592	active site
1284663001593	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1284663001594	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1284663001595	active site
1284663001596	dimer interface [polypeptide binding]; other site
1284663001597	multicopper oxidase; Provisional; Region: PRK10965
1284663001598	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1284663001599	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1284663001600	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
1284663001601	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1284663001602	substrate binding site [chemical binding]; other site
1284663001603	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
1284663001604	Uncharacterized conserved protein [Function unknown]; Region: COG3410
1284663001605	Transcriptional regulator; Region: Rrf2; pfam02082
1284663001606	Rrf2 family protein; Region: rrf2_super; TIGR00738
1284663001607	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1284663001608	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1284663001609	carboxyltransferase (CT) interaction site; other site
1284663001610	biotinylation site [posttranslational modification]; other site
1284663001611	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1284663001612	active site
1284663001613	tetramer interface [polypeptide binding]; other site
1284663001614	short chain dehydrogenase; Validated; Region: PRK06182
1284663001615	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1284663001616	NADP binding site [chemical binding]; other site
1284663001617	active site
1284663001618	steroid binding site; other site
1284663001619	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1284663001620	Helix-turn-helix domain; Region: HTH_38; pfam13936
1284663001621	Integrase core domain; Region: rve; pfam00665
1284663001622	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663001623	dimer interface [polypeptide binding]; other site
1284663001624	conserved gate region; other site
1284663001625	ABC-ATPase subunit interface; other site
1284663001626	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1284663001627	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1284663001628	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663001629	Walker A/P-loop; other site
1284663001630	ATP binding site [chemical binding]; other site
1284663001631	Q-loop/lid; other site
1284663001632	ABC transporter signature motif; other site
1284663001633	Walker B; other site
1284663001634	D-loop; other site
1284663001635	H-loop/switch region; other site
1284663001636	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1284663001637	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1284663001638	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1284663001639	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1284663001640	glycerol kinase; Provisional; Region: glpK; PRK00047
1284663001641	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1284663001642	N- and C-terminal domain interface [polypeptide binding]; other site
1284663001643	active site
1284663001644	MgATP binding site [chemical binding]; other site
1284663001645	catalytic site [active]
1284663001646	metal binding site [ion binding]; metal-binding site
1284663001647	glycerol binding site [chemical binding]; other site
1284663001648	homotetramer interface [polypeptide binding]; other site
1284663001649	homodimer interface [polypeptide binding]; other site
1284663001650	FBP binding site [chemical binding]; other site
1284663001651	protein IIAGlc interface [polypeptide binding]; other site
1284663001652	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1284663001653	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1284663001654	amphipathic channel; other site
1284663001655	Asn-Pro-Ala signature motifs; other site
1284663001656	galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527
1284663001657	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1284663001658	active site
1284663001659	substrate binding site [chemical binding]; other site
1284663001660	trimer interface [polypeptide binding]; other site
1284663001661	CoA binding site [chemical binding]; other site
1284663001662	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663001663	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663001664	putative substrate translocation pore; other site
1284663001665	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1284663001666	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1284663001667	Cupin domain; Region: Cupin_2; pfam07883
1284663001668	Helix-turn-helix domain; Region: HTH_18; pfam12833
1284663001669	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1284663001670	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1284663001671	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663001672	motif II; other site
1284663001673	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1284663001674	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1284663001675	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1284663001676	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1284663001677	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
1284663001678	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1284663001679	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1284663001680	CAAX protease self-immunity; Region: Abi; pfam02517
1284663001681	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1284663001682	MULE transposase domain; Region: MULE; pfam10551
1284663001683	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1284663001684	Helix-turn-helix domain; Region: HTH_38; pfam13936
1284663001685	Integrase core domain; Region: rve; pfam00665
1284663001686	potential frameshift: common BLAST hit: plnG
1284663001687	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
1284663001688	putative active site [active]
1284663001689	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1284663001690	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663001691	Walker A/P-loop; other site
1284663001692	ATP binding site [chemical binding]; other site
1284663001693	ABC transporter; Region: ABC_tran; pfam00005
1284663001694	Q-loop/lid; other site
1284663001695	ABC transporter signature motif; other site
1284663001696	Walker B; other site
1284663001697	D-loop; other site
1284663001698	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663001699	H-loop/switch region; other site
1284663001700	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
1284663001701	HlyD family secretion protein; Region: HlyD_3; pfam13437
1284663001702	CAAX protease self-immunity; Region: Abi; pfam02517
1284663001703	CAAX protease self-immunity; Region: Abi; pfam02517
1284663001704	CAAX protease self-immunity; Region: Abi; pfam02517
1284663001705	CAAX protease self-immunity; Region: Abi; pfam02517
1284663001706	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1284663001707	Part of AAA domain; Region: AAA_19; pfam13245
1284663001708	Family description; Region: UvrD_C_2; pfam13538
1284663001709	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1284663001710	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
1284663001711	putative active site [active]
1284663001712	catalytic triad [active]
1284663001713	putative dimer interface [polypeptide binding]; other site
1284663001714	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1284663001715	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1284663001716	active site
1284663001717	HIGH motif; other site
1284663001718	dimer interface [polypeptide binding]; other site
1284663001719	KMSKS motif; other site
1284663001720	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1284663001721	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1284663001722	DNA-binding site [nucleotide binding]; DNA binding site
1284663001723	UTRA domain; Region: UTRA; pfam07702
1284663001724	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1284663001725	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1284663001726	N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; Region: Tweety_N; cl12141
1284663001727	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
1284663001728	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1284663001729	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1284663001730	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1284663001731	beta-galactosidase; Region: BGL; TIGR03356
1284663001732	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1284663001733	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1284663001734	nucleotide binding site [chemical binding]; other site
1284663001735	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1284663001736	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1284663001737	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1284663001738	putative active site [active]
1284663001739	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1284663001740	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1284663001741	FMN binding site [chemical binding]; other site
1284663001742	active site
1284663001743	catalytic residues [active]
1284663001744	substrate binding site [chemical binding]; other site
1284663001745	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1284663001746	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1284663001747	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
1284663001748	homodimer interface [polypeptide binding]; other site
1284663001749	catalytic residues [active]
1284663001750	NAD binding site [chemical binding]; other site
1284663001751	substrate binding pocket [chemical binding]; other site
1284663001752	flexible flap; other site
1284663001753	NAD-dependent deacetylase; Provisional; Region: PRK00481
1284663001754	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
1284663001755	NAD+ binding site [chemical binding]; other site
1284663001756	substrate binding site [chemical binding]; other site
1284663001757	putative Zn binding site [ion binding]; other site
1284663001758	Protein of unknown function DUF72; Region: DUF72; pfam01904
1284663001759	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1284663001760	nudix motif; other site
1284663001761	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1284663001762	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1284663001763	HIGH motif; other site
1284663001764	active site
1284663001765	KMSKS motif; other site
1284663001766	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1284663001767	tRNA binding surface [nucleotide binding]; other site
1284663001768	anticodon binding site; other site
1284663001769	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1284663001770	dimer interface [polypeptide binding]; other site
1284663001771	putative tRNA-binding site [nucleotide binding]; other site
1284663001772	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1284663001773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663001774	putative substrate translocation pore; other site
1284663001775	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1284663001776	active site
1284663001777	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1284663001778	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1284663001779	putative active site [active]
1284663001780	putative metal binding site [ion binding]; other site
1284663001781	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1284663001782	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1284663001783	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1284663001784	S-adenosylmethionine binding site [chemical binding]; other site
1284663001785	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
1284663001786	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1284663001787	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1284663001788	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1284663001789	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1284663001790	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750
1284663001791	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1284663001792	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1284663001793	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1284663001794	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1284663001795	putative PBP binding regions; other site
1284663001796	ABC-ATPase subunit  interface; other site
1284663001797	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1284663001798	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
1284663001799	pur operon repressor; Provisional; Region: PRK09213
1284663001800	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1284663001801	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1284663001802	active site
1284663001803	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1284663001804	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1284663001805	Substrate binding site; other site
1284663001806	Mg++ binding site; other site
1284663001807	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1284663001808	active site
1284663001809	substrate binding site [chemical binding]; other site
1284663001810	CoA binding site [chemical binding]; other site
1284663001811	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1284663001812	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1284663001813	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1284663001814	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1284663001815	active site
1284663001816	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1284663001817	putative active site [active]
1284663001818	sugar phosphate phosphatase; Provisional; Region: PRK10513
1284663001819	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663001820	active site
1284663001821	motif I; other site
1284663001822	motif II; other site
1284663001823	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663001824	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1284663001825	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1284663001826	Zn2+ binding site [ion binding]; other site
1284663001827	Mg2+ binding site [ion binding]; other site
1284663001828	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1284663001829	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
1284663001830	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
1284663001831	CTP synthetase; Validated; Region: pyrG; PRK05380
1284663001832	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1284663001833	Catalytic site [active]
1284663001834	active site
1284663001835	UTP binding site [chemical binding]; other site
1284663001836	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1284663001837	active site
1284663001838	putative oxyanion hole; other site
1284663001839	catalytic triad [active]
1284663001840	seryl-tRNA synthetase; Provisional; Region: PRK05431
1284663001841	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1284663001842	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1284663001843	dimer interface [polypeptide binding]; other site
1284663001844	active site
1284663001845	motif 1; other site
1284663001846	motif 2; other site
1284663001847	motif 3; other site
1284663001848	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1284663001849	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1284663001850	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1284663001851	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1284663001852	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1284663001853	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1284663001854	YheO-like PAS domain; Region: PAS_6; pfam08348
1284663001855	HTH domain; Region: HTH_22; pfam13309
1284663001856	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1284663001857	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1284663001858	hinge; other site
1284663001859	active site
1284663001860	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1284663001861	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1284663001862	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1284663001863	RNA binding site [nucleotide binding]; other site
1284663001864	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1284663001865	multimer interface [polypeptide binding]; other site
1284663001866	Walker A motif; other site
1284663001867	ATP binding site [chemical binding]; other site
1284663001868	Walker B motif; other site
1284663001869	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1284663001870	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
1284663001871	active site
1284663001872	catalytic site [active]
1284663001873	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
1284663001874	heat shock protein HtpX; Provisional; Region: PRK04897
1284663001875	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1284663001876	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1284663001877	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1284663001878	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1284663001879	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1284663001880	ATP binding site [chemical binding]; other site
1284663001881	Mg++ binding site [ion binding]; other site
1284663001882	motif III; other site
1284663001883	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1284663001884	nucleotide binding region [chemical binding]; other site
1284663001885	ATP-binding site [chemical binding]; other site
1284663001886	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1284663001887	alanine racemase; Reviewed; Region: alr; PRK00053
1284663001888	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1284663001889	active site
1284663001890	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1284663001891	dimer interface [polypeptide binding]; other site
1284663001892	substrate binding site [chemical binding]; other site
1284663001893	catalytic residues [active]
1284663001894	PemK-like protein; Region: PemK; pfam02452
1284663001895	K+ potassium transporter; Region: K_trans; cl15781
1284663001896	NMT1/THI5 like; Region: NMT1; pfam09084
1284663001897	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1284663001898	substrate binding pocket [chemical binding]; other site
1284663001899	membrane-bound complex binding site; other site
1284663001900	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1284663001901	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663001902	dimer interface [polypeptide binding]; other site
1284663001903	conserved gate region; other site
1284663001904	putative PBP binding loops; other site
1284663001905	ABC-ATPase subunit interface; other site
1284663001906	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1284663001907	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1284663001908	Walker A/P-loop; other site
1284663001909	ATP binding site [chemical binding]; other site
1284663001910	Q-loop/lid; other site
1284663001911	ABC transporter signature motif; other site
1284663001912	Walker B; other site
1284663001913	D-loop; other site
1284663001914	H-loop/switch region; other site
1284663001915	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815
1284663001916	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1284663001917	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1284663001918	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1284663001919	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1284663001920	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1284663001921	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838
1284663001922	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
1284663001923	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1284663001924	catalytic site [active]
1284663001925	subunit interface [polypeptide binding]; other site
1284663001926	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
1284663001927	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1284663001928	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1284663001929	heterotetramer interface [polypeptide binding]; other site
1284663001930	active site pocket [active]
1284663001931	cleavage site
1284663001932	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
1284663001933	nucleotide binding site [chemical binding]; other site
1284663001934	N-acetyl-L-glutamate binding site [chemical binding]; other site
1284663001935	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
1284663001936	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1284663001937	inhibitor-cofactor binding pocket; inhibition site
1284663001938	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663001939	catalytic residue [active]
1284663001940	ornithine carbamoyltransferase; Validated; Region: PRK02102
1284663001941	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1284663001942	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1284663001943	QueT transporter; Region: QueT; pfam06177
1284663001944	FOG: CBS domain [General function prediction only]; Region: COG0517
1284663001945	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1284663001946	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
1284663001947	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
1284663001948	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1284663001949	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1284663001950	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1284663001951	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1284663001952	NAD binding site [chemical binding]; other site
1284663001953	dimer interface [polypeptide binding]; other site
1284663001954	substrate binding site [chemical binding]; other site
1284663001955	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1284663001956	putative active site [active]
1284663001957	catalytic residue [active]
1284663001958	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1284663001959	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1284663001960	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1284663001961	ATP binding site [chemical binding]; other site
1284663001962	putative Mg++ binding site [ion binding]; other site
1284663001963	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1284663001964	nucleotide binding region [chemical binding]; other site
1284663001965	ATP-binding site [chemical binding]; other site
1284663001966	TRCF domain; Region: TRCF; pfam03461
1284663001967	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1284663001968	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1284663001969	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1284663001970	RNA binding surface [nucleotide binding]; other site
1284663001971	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1284663001972	Septum formation initiator; Region: DivIC; pfam04977
1284663001973	hypothetical protein; Provisional; Region: PRK08582
1284663001974	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1284663001975	RNA binding site [nucleotide binding]; other site
1284663001976	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1284663001977	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1284663001978	Ligand Binding Site [chemical binding]; other site
1284663001979	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1284663001980	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1284663001981	active site
1284663001982	FtsH Extracellular; Region: FtsH_ext; pfam06480
1284663001983	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1284663001984	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663001985	Walker A motif; other site
1284663001986	ATP binding site [chemical binding]; other site
1284663001987	Walker B motif; other site
1284663001988	arginine finger; other site
1284663001989	Peptidase family M41; Region: Peptidase_M41; pfam01434
1284663001990	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1284663001991	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1284663001992	dimerization interface [polypeptide binding]; other site
1284663001993	domain crossover interface; other site
1284663001994	redox-dependent activation switch; other site
1284663001995	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1284663001996	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1284663001997	FMN binding site [chemical binding]; other site
1284663001998	active site
1284663001999	catalytic residues [active]
1284663002000	substrate binding site [chemical binding]; other site
1284663002001	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1284663002002	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1284663002003	dimer interface [polypeptide binding]; other site
1284663002004	putative anticodon binding site; other site
1284663002005	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1284663002006	motif 1; other site
1284663002007	active site
1284663002008	motif 2; other site
1284663002009	motif 3; other site
1284663002010	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1284663002011	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663002012	putative substrate translocation pore; other site
1284663002013	POT family; Region: PTR2; cl17359
1284663002014	putative phosphoesterase; Region: acc_ester; TIGR03729
1284663002015	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1284663002016	Cupin domain; Region: Cupin_2; cl17218
1284663002017	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1284663002018	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1284663002019	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1284663002020	active site
1284663002021	metal binding site [ion binding]; metal-binding site
1284663002022	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1284663002023	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1284663002024	transmembrane helices; other site
1284663002025	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
1284663002026	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1284663002027	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
1284663002028	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1284663002029	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1284663002030	active site
1284663002031	dimer interface [polypeptide binding]; other site
1284663002032	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1284663002033	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1284663002034	DNA-binding site [nucleotide binding]; DNA binding site
1284663002035	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1284663002036	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1284663002037	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1284663002038	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1284663002039	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1284663002040	active site
1284663002041	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1284663002042	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1284663002043	homodimer interface [polypeptide binding]; other site
1284663002044	NAD binding pocket [chemical binding]; other site
1284663002045	ATP binding pocket [chemical binding]; other site
1284663002046	Mg binding site [ion binding]; other site
1284663002047	active-site loop [active]
1284663002048	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1284663002049	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1284663002050	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1284663002051	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1284663002052	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663002053	motif II; other site
1284663002054	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1284663002055	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1284663002056	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1284663002057	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1284663002058	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1284663002059	RNA binding site [nucleotide binding]; other site
1284663002060	hypothetical protein; Provisional; Region: PRK04351
1284663002061	SprT homologues; Region: SprT; cl01182
1284663002062	homoserine dehydrogenase; Provisional; Region: PRK06349
1284663002063	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1284663002064	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1284663002065	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1284663002066	homoserine kinase; Provisional; Region: PRK01212
1284663002067	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1284663002068	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
1284663002069	putative active site [active]
1284663002070	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
1284663002071	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1284663002072	active pocket/dimerization site; other site
1284663002073	active site
1284663002074	phosphorylation site [posttranslational modification]
1284663002075	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1284663002076	active site
1284663002077	phosphorylation site [posttranslational modification]
1284663002078	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
1284663002079	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
1284663002080	Domain of unknown function (DUF956); Region: DUF956; pfam06115
1284663002081	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1284663002082	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663002083	Walker A motif; other site
1284663002084	ATP binding site [chemical binding]; other site
1284663002085	Walker B motif; other site
1284663002086	arginine finger; other site
1284663002087	Transcriptional antiterminator [Transcription]; Region: COG3933
1284663002088	PRD domain; Region: PRD; pfam00874
1284663002089	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1284663002090	active pocket/dimerization site; other site
1284663002091	active site
1284663002092	phosphorylation site [posttranslational modification]
1284663002093	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1284663002094	active pocket/dimerization site; other site
1284663002095	active site
1284663002096	phosphorylation site [posttranslational modification]
1284663002097	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1284663002098	active site
1284663002099	phosphorylation site [posttranslational modification]
1284663002100	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
1284663002101	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1284663002102	dimer interface [polypeptide binding]; other site
1284663002103	active site
1284663002104	CoA binding pocket [chemical binding]; other site
1284663002105	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
1284663002106	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1284663002107	carboxyltransferase (CT) interaction site; other site
1284663002108	biotinylation site [posttranslational modification]; other site
1284663002109	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1284663002110	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1284663002111	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1284663002112	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1284663002113	acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515
1284663002114	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1284663002115	substrate binding site [chemical binding]; other site
1284663002116	trimer interface [polypeptide binding]; other site
1284663002117	oxyanion hole (OAH) forming residues; other site
1284663002118	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1284663002119	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1284663002120	Membrane transport protein; Region: Mem_trans; pfam03547
1284663002121	EamA-like transporter family; Region: EamA; pfam00892
1284663002122	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1284663002123	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1284663002124	catalytic core [active]
1284663002125	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1284663002126	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
1284663002127	active site
1284663002128	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1284663002129	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1284663002130	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1284663002131	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1284663002132	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1284663002133	active site
1284663002134	dimer interface [polypeptide binding]; other site
1284663002135	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663002136	Coenzyme A binding pocket [chemical binding]; other site
1284663002137	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1284663002138	trimer interface [polypeptide binding]; other site
1284663002139	active site
1284663002140	DNA repair protein RadA; Provisional; Region: PRK11823
1284663002141	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1284663002142	Walker A motif/ATP binding site; other site
1284663002143	ATP binding site [chemical binding]; other site
1284663002144	Walker B motif; other site
1284663002145	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1284663002146	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1284663002147	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1284663002148	putative active site [active]
1284663002149	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1284663002150	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1284663002151	active site
1284663002152	HIGH motif; other site
1284663002153	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1284663002154	active site
1284663002155	KMSKS motif; other site
1284663002156	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1284663002157	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1284663002158	active site
1284663002159	HIGH motif; other site
1284663002160	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1284663002161	KMSKS motif; other site
1284663002162	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1284663002163	tRNA binding surface [nucleotide binding]; other site
1284663002164	anticodon binding site; other site
1284663002165	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
1284663002166	active site
1284663002167	metal binding site [ion binding]; metal-binding site
1284663002168	dimerization interface [polypeptide binding]; other site
1284663002169	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1284663002170	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1284663002171	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1284663002172	YacP-like NYN domain; Region: NYN_YacP; pfam05991
1284663002173	RNA polymerase factor sigma-70; Validated; Region: PRK08295
1284663002174	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1284663002175	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1284663002176	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1284663002177	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1284663002178	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1284663002179	putative homodimer interface [polypeptide binding]; other site
1284663002180	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1284663002181	heterodimer interface [polypeptide binding]; other site
1284663002182	homodimer interface [polypeptide binding]; other site
1284663002183	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1284663002184	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1284663002185	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1284663002186	23S rRNA interface [nucleotide binding]; other site
1284663002187	L7/L12 interface [polypeptide binding]; other site
1284663002188	putative thiostrepton binding site; other site
1284663002189	L25 interface [polypeptide binding]; other site
1284663002190	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1284663002191	mRNA/rRNA interface [nucleotide binding]; other site
1284663002192	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1284663002193	23S rRNA interface [nucleotide binding]; other site
1284663002194	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1284663002195	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1284663002196	peripheral dimer interface [polypeptide binding]; other site
1284663002197	core dimer interface [polypeptide binding]; other site
1284663002198	L10 interface [polypeptide binding]; other site
1284663002199	L11 interface [polypeptide binding]; other site
1284663002200	putative EF-Tu interaction site [polypeptide binding]; other site
1284663002201	putative EF-G interaction site [polypeptide binding]; other site
1284663002202	Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250
1284663002203	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
1284663002204	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1284663002205	Predicted integral membrane protein [Function unknown]; Region: COG0392
1284663002206	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1284663002207	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1284663002208	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1284663002209	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663002210	non-specific DNA binding site [nucleotide binding]; other site
1284663002211	salt bridge; other site
1284663002212	sequence-specific DNA binding site [nucleotide binding]; other site
1284663002213	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
1284663002214	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1284663002215	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1284663002216	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1284663002217	dimer interface [polypeptide binding]; other site
1284663002218	putative radical transfer pathway; other site
1284663002219	diiron center [ion binding]; other site
1284663002220	tyrosyl radical; other site
1284663002221	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
1284663002222	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1284663002223	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1284663002224	active site
1284663002225	dimer interface [polypeptide binding]; other site
1284663002226	catalytic residues [active]
1284663002227	effector binding site; other site
1284663002228	R2 peptide binding site; other site
1284663002229	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1284663002230	catalytic residues [active]
1284663002231	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
1284663002232	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1284663002233	S-adenosylmethionine binding site [chemical binding]; other site
1284663002234	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1284663002235	nucleoside/Zn binding site; other site
1284663002236	dimer interface [polypeptide binding]; other site
1284663002237	catalytic motif [active]
1284663002238	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1284663002239	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663002240	Walker A motif; other site
1284663002241	ATP binding site [chemical binding]; other site
1284663002242	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1284663002243	Walker B motif; other site
1284663002244	arginine finger; other site
1284663002245	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1284663002246	hypothetical protein; Validated; Region: PRK00153
1284663002247	recombination protein RecR; Reviewed; Region: recR; PRK00076
1284663002248	RecR protein; Region: RecR; pfam02132
1284663002249	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1284663002250	putative active site [active]
1284663002251	putative metal-binding site [ion binding]; other site
1284663002252	tetramer interface [polypeptide binding]; other site
1284663002253	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
1284663002254	thymidylate kinase; Validated; Region: tmk; PRK00698
1284663002255	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1284663002256	TMP-binding site; other site
1284663002257	ATP-binding site [chemical binding]; other site
1284663002258	Protein of unknown function (DUF970); Region: DUF970; pfam06153
1284663002259	DNA polymerase III subunit delta'; Validated; Region: PRK08058
1284663002260	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1284663002261	Protein of unknown function (DUF972); Region: DUF972; pfam06156
1284663002262	Predicted methyltransferases [General function prediction only]; Region: COG0313
1284663002263	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1284663002264	putative SAM binding site [chemical binding]; other site
1284663002265	putative homodimer interface [polypeptide binding]; other site
1284663002266	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
1284663002267	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1284663002268	active site
1284663002269	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1284663002270	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1284663002271	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1284663002272	NAD binding site [chemical binding]; other site
1284663002273	homodimer interface [polypeptide binding]; other site
1284663002274	active site
1284663002275	substrate binding site [chemical binding]; other site
1284663002276	2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326
1284663002277	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1284663002278	catalytic residue [active]
1284663002279	phosphonoacetaldehyde hydrolase; Region: phosphonatase; TIGR01422
1284663002280	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663002281	motif II; other site
1284663002282	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1284663002283	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663002284	dimer interface [polypeptide binding]; other site
1284663002285	conserved gate region; other site
1284663002286	ABC-ATPase subunit interface; other site
1284663002287	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1284663002288	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663002289	dimer interface [polypeptide binding]; other site
1284663002290	conserved gate region; other site
1284663002291	ABC-ATPase subunit interface; other site
1284663002292	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
1284663002293	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1284663002294	Walker A/P-loop; other site
1284663002295	ATP binding site [chemical binding]; other site
1284663002296	Q-loop/lid; other site
1284663002297	ABC transporter signature motif; other site
1284663002298	Walker B; other site
1284663002299	D-loop; other site
1284663002300	H-loop/switch region; other site
1284663002301	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1284663002302	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1284663002303	Glycoprotease family; Region: Peptidase_M22; pfam00814
1284663002304	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1284663002305	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663002306	Coenzyme A binding pocket [chemical binding]; other site
1284663002307	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1284663002308	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663002309	Coenzyme A binding pocket [chemical binding]; other site
1284663002310	UGMP family protein; Validated; Region: PRK09604
1284663002311	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1284663002312	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
1284663002313	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1284663002314	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1284663002315	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1284663002316	ABC transporter; Region: ABC_tran_2; pfam12848
1284663002317	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1284663002318	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1284663002319	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1284663002320	CoA binding domain; Region: CoA_binding; pfam02629
1284663002321	CAAX protease self-immunity; Region: Abi; pfam02517
1284663002322	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1284663002323	oligomerisation interface [polypeptide binding]; other site
1284663002324	mobile loop; other site
1284663002325	roof hairpin; other site
1284663002326	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1284663002327	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1284663002328	ring oligomerisation interface [polypeptide binding]; other site
1284663002329	ATP/Mg binding site [chemical binding]; other site
1284663002330	stacking interactions; other site
1284663002331	hinge regions; other site
1284663002332	Amino acid permease; Region: AA_permease_2; pfam13520
1284663002333	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1284663002334	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1284663002335	Mg++ binding site [ion binding]; other site
1284663002336	putative catalytic motif [active]
1284663002337	substrate binding site [chemical binding]; other site
1284663002338	PBP superfamily domain; Region: PBP_like_2; cl17296
1284663002339	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1284663002340	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1284663002341	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1284663002342	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1284663002343	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
1284663002344	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1284663002345	ATP binding site [chemical binding]; other site
1284663002346	putative Mg++ binding site [ion binding]; other site
1284663002347	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1284663002348	ATP-binding site [chemical binding]; other site
1284663002349	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1284663002350	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1284663002351	active site
1284663002352	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1284663002353	30S subunit binding site; other site
1284663002354	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906
1284663002355	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1284663002356	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1284663002357	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1284663002358	nucleotide binding region [chemical binding]; other site
1284663002359	ATP-binding site [chemical binding]; other site
1284663002360	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1284663002361	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1284663002362	RF-1 domain; Region: RF-1; pfam00472
1284663002363	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1284663002364	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1284663002365	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1284663002366	active site
1284663002367	phosphorylation site [posttranslational modification]
1284663002368	intermolecular recognition site; other site
1284663002369	dimerization interface [polypeptide binding]; other site
1284663002370	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1284663002371	DNA binding site [nucleotide binding]
1284663002372	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1284663002373	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1284663002374	dimer interface [polypeptide binding]; other site
1284663002375	phosphorylation site [posttranslational modification]
1284663002376	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1284663002377	ATP binding site [chemical binding]; other site
1284663002378	Mg2+ binding site [ion binding]; other site
1284663002379	G-X-G motif; other site
1284663002380	PBP superfamily domain; Region: PBP_like_2; cl17296
1284663002381	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1284663002382	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663002383	dimer interface [polypeptide binding]; other site
1284663002384	conserved gate region; other site
1284663002385	putative PBP binding loops; other site
1284663002386	ABC-ATPase subunit interface; other site
1284663002387	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1284663002388	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663002389	putative PBP binding loops; other site
1284663002390	ABC-ATPase subunit interface; other site
1284663002391	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
1284663002392	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1284663002393	Walker A/P-loop; other site
1284663002394	ATP binding site [chemical binding]; other site
1284663002395	Q-loop/lid; other site
1284663002396	ABC transporter signature motif; other site
1284663002397	Walker B; other site
1284663002398	D-loop; other site
1284663002399	H-loop/switch region; other site
1284663002400	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
1284663002401	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1284663002402	Walker A/P-loop; other site
1284663002403	ATP binding site [chemical binding]; other site
1284663002404	Q-loop/lid; other site
1284663002405	ABC transporter signature motif; other site
1284663002406	Walker B; other site
1284663002407	D-loop; other site
1284663002408	H-loop/switch region; other site
1284663002409	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1284663002410	PhoU domain; Region: PhoU; pfam01895
1284663002411	PhoU domain; Region: PhoU; pfam01895
1284663002412	PspC domain; Region: PspC; pfam04024
1284663002413	Predicted membrane protein [Function unknown]; Region: COG1950
1284663002414	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1284663002415	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1284663002416	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1284663002417	Hpr binding site; other site
1284663002418	active site
1284663002419	homohexamer subunit interaction site [polypeptide binding]; other site
1284663002420	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1284663002421	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1284663002422	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1284663002423	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1284663002424	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1284663002425	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1284663002426	active site
1284663002427	tetramer interface; other site
1284663002428	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1284663002429	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
1284663002430	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1284663002431	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1284663002432	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1284663002433	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1284663002434	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1284663002435	Predicted membrane protein [Function unknown]; Region: COG2323
1284663002436	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
1284663002437	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1284663002438	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1284663002439	active site
1284663002440	substrate binding site [chemical binding]; other site
1284663002441	metal binding site [ion binding]; metal-binding site
1284663002442	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1284663002443	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
1284663002444	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1284663002445	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1284663002446	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1284663002447	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
1284663002448	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663002449	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663002450	putative substrate translocation pore; other site
1284663002451	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1284663002452	Zn2+ binding site [ion binding]; other site
1284663002453	Mg2+ binding site [ion binding]; other site
1284663002454	excinuclease ABC subunit B; Provisional; Region: PRK05298
1284663002455	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1284663002456	ATP binding site [chemical binding]; other site
1284663002457	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1284663002458	nucleotide binding region [chemical binding]; other site
1284663002459	ATP-binding site [chemical binding]; other site
1284663002460	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1284663002461	UvrB/uvrC motif; Region: UVR; pfam02151
1284663002462	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1284663002463	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1284663002464	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1284663002465	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1284663002466	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1284663002467	argininosuccinate synthase; Provisional; Region: PRK13820
1284663002468	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1284663002469	ANP binding site [chemical binding]; other site
1284663002470	Substrate Binding Site II [chemical binding]; other site
1284663002471	Substrate Binding Site I [chemical binding]; other site
1284663002472	argininosuccinate lyase; Provisional; Region: PRK00855
1284663002473	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1284663002474	active sites [active]
1284663002475	tetramer interface [polypeptide binding]; other site
1284663002476	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
1284663002477	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1284663002478	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1284663002479	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1284663002480	phosphate binding site [ion binding]; other site
1284663002481	putative substrate binding pocket [chemical binding]; other site
1284663002482	dimer interface [polypeptide binding]; other site
1284663002483	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1284663002484	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1284663002485	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1284663002486	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1284663002487	peptide binding site [polypeptide binding]; other site
1284663002488	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
1284663002489	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1284663002490	putative ligand binding site [chemical binding]; other site
1284663002491	putative NAD binding site [chemical binding]; other site
1284663002492	catalytic site [active]
1284663002493	Clp protease; Region: CLP_protease; pfam00574
1284663002494	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1284663002495	oligomer interface [polypeptide binding]; other site
1284663002496	active site residues [active]
1284663002497	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1284663002498	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1284663002499	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1284663002500	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1284663002501	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1284663002502	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1284663002503	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1284663002504	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1284663002505	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1284663002506	Phosphoglycerate kinase; Region: PGK; pfam00162
1284663002507	substrate binding site [chemical binding]; other site
1284663002508	hinge regions; other site
1284663002509	ADP binding site [chemical binding]; other site
1284663002510	catalytic site [active]
1284663002511	triosephosphate isomerase; Provisional; Region: PRK14567
1284663002512	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1284663002513	dimer interface [polypeptide binding]; other site
1284663002514	substrate binding site [chemical binding]; other site
1284663002515	catalytic triad [active]
1284663002516	enolase; Provisional; Region: eno; PRK00077
1284663002517	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1284663002518	dimer interface [polypeptide binding]; other site
1284663002519	metal binding site [ion binding]; metal-binding site
1284663002520	substrate binding pocket [chemical binding]; other site
1284663002521	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1284663002522	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1284663002523	Cl- selectivity filter; other site
1284663002524	Cl- binding residues [ion binding]; other site
1284663002525	pore gating glutamate residue; other site
1284663002526	dimer interface [polypeptide binding]; other site
1284663002527	H+/Cl- coupling transport residue; other site
1284663002528	TrkA-C domain; Region: TrkA_C; pfam02080
1284663002529	protein translocase, SecG subunit; Region: secG; TIGR00810
1284663002530	Esterase/lipase [General function prediction only]; Region: COG1647
1284663002531	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1284663002532	ribonuclease R; Region: RNase_R; TIGR02063
1284663002533	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1284663002534	RNB domain; Region: RNB; pfam00773
1284663002535	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1284663002536	RNA binding site [nucleotide binding]; other site
1284663002537	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1284663002538	SmpB-tmRNA interface; other site
1284663002539	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1284663002540	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
1284663002541	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
1284663002542	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1284663002543	Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297
1284663002544	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1284663002545	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1284663002546	substrate binding pocket [chemical binding]; other site
1284663002547	membrane-bound complex binding site; other site
1284663002548	hinge residues; other site
1284663002549	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663002550	dimer interface [polypeptide binding]; other site
1284663002551	conserved gate region; other site
1284663002552	putative PBP binding loops; other site
1284663002553	ABC-ATPase subunit interface; other site
1284663002554	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1284663002555	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1284663002556	Walker A/P-loop; other site
1284663002557	ATP binding site [chemical binding]; other site
1284663002558	Q-loop/lid; other site
1284663002559	ABC transporter signature motif; other site
1284663002560	Walker B; other site
1284663002561	D-loop; other site
1284663002562	H-loop/switch region; other site
1284663002563	Tubby C 2; Region: Tub_2; cl02043
1284663002564	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663002565	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1284663002566	active site
1284663002567	motif I; other site
1284663002568	motif II; other site
1284663002569	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1284663002570	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1284663002571	ligand binding site [chemical binding]; other site
1284663002572	active site
1284663002573	UGI interface [polypeptide binding]; other site
1284663002574	catalytic site [active]
1284663002575	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1284663002576	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1284663002577	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1284663002578	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663002579	Coenzyme A binding pocket [chemical binding]; other site
1284663002580	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1284663002581	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1284663002582	active site
1284663002583	catalytic site [active]
1284663002584	substrate binding site [chemical binding]; other site
1284663002585	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
1284663002586	active site
1284663002587	putative catalytic site [active]
1284663002588	DNA binding site [nucleotide binding]
1284663002589	putative phosphate binding site [ion binding]; other site
1284663002590	metal binding site A [ion binding]; metal-binding site
1284663002591	AP binding site [nucleotide binding]; other site
1284663002592	metal binding site B [ion binding]; metal-binding site
1284663002593	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1284663002594	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1284663002595	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1284663002596	FAD binding domain; Region: FAD_binding_4; pfam01565
1284663002597	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1284663002598	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1284663002599	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1284663002600	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1284663002601	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
1284663002602	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1284663002603	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1284663002604	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1284663002605	YbbR-like protein; Region: YbbR; pfam07949
1284663002606	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1284663002607	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1284663002608	active site
1284663002609	substrate binding site [chemical binding]; other site
1284663002610	metal binding site [ion binding]; metal-binding site
1284663002611	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1284663002612	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1284663002613	glutaminase active site [active]
1284663002614	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1284663002615	dimer interface [polypeptide binding]; other site
1284663002616	active site
1284663002617	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1284663002618	dimer interface [polypeptide binding]; other site
1284663002619	active site
1284663002620	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1284663002621	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1284663002622	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663002623	active site
1284663002624	motif I; other site
1284663002625	motif II; other site
1284663002626	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1284663002627	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663002628	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1284663002629	active site
1284663002630	catalytic residues [active]
1284663002631	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1284663002632	dimer interface [polypeptide binding]; other site
1284663002633	FMN binding site [chemical binding]; other site
1284663002634	NADPH bind site [chemical binding]; other site
1284663002635	H+ Antiporter protein; Region: 2A0121; TIGR00900
1284663002636	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663002637	putative substrate translocation pore; other site
1284663002638	glycerol kinase; Provisional; Region: glpK; PRK00047
1284663002639	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1284663002640	N- and C-terminal domain interface [polypeptide binding]; other site
1284663002641	active site
1284663002642	MgATP binding site [chemical binding]; other site
1284663002643	catalytic site [active]
1284663002644	metal binding site [ion binding]; metal-binding site
1284663002645	glycerol binding site [chemical binding]; other site
1284663002646	homotetramer interface [polypeptide binding]; other site
1284663002647	homodimer interface [polypeptide binding]; other site
1284663002648	FBP binding site [chemical binding]; other site
1284663002649	protein IIAGlc interface [polypeptide binding]; other site
1284663002650	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
1284663002651	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1284663002652	putative catalytic residues [active]
1284663002653	thiol/disulfide switch; other site
1284663002654	ArsC family; Region: ArsC; pfam03960
1284663002655	VanZ like family; Region: VanZ; cl01971
1284663002656	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663002657	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663002658	putative substrate translocation pore; other site
1284663002659	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663002660	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1284663002661	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1284663002662	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1284663002663	polyphosphate kinase 1; Region: poly_P_kin; TIGR03705
1284663002664	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1284663002665	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1284663002666	putative domain interface [polypeptide binding]; other site
1284663002667	putative active site [active]
1284663002668	catalytic site [active]
1284663002669	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1284663002670	putative domain interface [polypeptide binding]; other site
1284663002671	putative active site [active]
1284663002672	catalytic site [active]
1284663002673	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1284663002674	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1284663002675	Zn2+ binding site [ion binding]; other site
1284663002676	Mg2+ binding site [ion binding]; other site
1284663002677	LicD family; Region: LicD; pfam04991
1284663002678	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1284663002679	MarR family; Region: MarR_2; pfam12802
1284663002680	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1284663002681	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
1284663002682	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1284663002683	PYR/PP interface [polypeptide binding]; other site
1284663002684	dimer interface [polypeptide binding]; other site
1284663002685	tetramer interface [polypeptide binding]; other site
1284663002686	TPP binding site [chemical binding]; other site
1284663002687	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1284663002688	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1284663002689	TPP-binding site [chemical binding]; other site
1284663002690	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1284663002691	active site
1284663002692	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
1284663002693	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1284663002694	PYR/PP interface [polypeptide binding]; other site
1284663002695	dimer interface [polypeptide binding]; other site
1284663002696	tetramer interface [polypeptide binding]; other site
1284663002697	TPP binding site [chemical binding]; other site
1284663002698	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1284663002699	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1284663002700	TPP-binding site [chemical binding]; other site
1284663002701	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
1284663002702	recA bacterial DNA recombination protein; Region: RecA; cl17211
1284663002703	TAP-like protein; Region: Abhydrolase_4; pfam08386
1284663002704	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1284663002705	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
1284663002706	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1284663002707	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1284663002708	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1284663002709	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1284663002710	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1284663002711	catalytic triad [active]
1284663002712	catalytic triad [active]
1284663002713	oxyanion hole [active]
1284663002714	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
1284663002715	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940
1284663002716	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1284663002717	OsmC-like protein; Region: OsmC; cl00767
1284663002718	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
1284663002719	amino acid transporter; Region: 2A0306; TIGR00909
1284663002720	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1284663002721	AP2 domain; Region: AP2; pfam00847
1284663002722	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1284663002723	substrate binding site [chemical binding]; other site
1284663002724	ATP binding site [chemical binding]; other site
1284663002725	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428
1284663002726	active site
1284663002727	Ap4A binding cleft/pocket [chemical binding]; other site
1284663002728	P4 phosphate binding site; other site
1284663002729	nudix motif; other site
1284663002730	putative P2/P3 phosphate binding site [ion binding]; other site
1284663002731	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1284663002732	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1284663002733	catalytic site [active]
1284663002734	G-X2-G-X-G-K; other site
1284663002735	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1284663002736	metal binding site 2 [ion binding]; metal-binding site
1284663002737	putative DNA binding helix; other site
1284663002738	metal binding site 1 [ion binding]; metal-binding site
1284663002739	dimer interface [polypeptide binding]; other site
1284663002740	structural Zn2+ binding site [ion binding]; other site
1284663002741	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1284663002742	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663002743	motif II; other site
1284663002744	aromatic amino acid aminotransferase; Validated; Region: PRK07309
1284663002745	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1284663002746	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663002747	homodimer interface [polypeptide binding]; other site
1284663002748	catalytic residue [active]
1284663002749	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
1284663002750	D-lactate dehydrogenase; Validated; Region: PRK08605
1284663002751	homodimer interface [polypeptide binding]; other site
1284663002752	ligand binding site [chemical binding]; other site
1284663002753	NAD binding site [chemical binding]; other site
1284663002754	catalytic site [active]
1284663002755	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1284663002756	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1284663002757	Walker A/P-loop; other site
1284663002758	ATP binding site [chemical binding]; other site
1284663002759	Q-loop/lid; other site
1284663002760	ABC transporter signature motif; other site
1284663002761	Walker B; other site
1284663002762	D-loop; other site
1284663002763	H-loop/switch region; other site
1284663002764	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1284663002765	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1284663002766	substrate binding pocket [chemical binding]; other site
1284663002767	membrane-bound complex binding site; other site
1284663002768	hinge residues; other site
1284663002769	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1284663002770	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663002771	dimer interface [polypeptide binding]; other site
1284663002772	conserved gate region; other site
1284663002773	putative PBP binding loops; other site
1284663002774	ABC-ATPase subunit interface; other site
1284663002775	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663002776	dimer interface [polypeptide binding]; other site
1284663002777	conserved gate region; other site
1284663002778	putative PBP binding loops; other site
1284663002779	ABC-ATPase subunit interface; other site
1284663002780	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
1284663002781	HPr interaction site; other site
1284663002782	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1284663002783	active site
1284663002784	phosphorylation site [posttranslational modification]
1284663002785	CAT RNA binding domain; Region: CAT_RBD; smart01061
1284663002786	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1284663002787	PRD domain; Region: PRD; pfam00874
1284663002788	PRD domain; Region: PRD; pfam00874
1284663002789	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1284663002790	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1284663002791	active site turn [active]
1284663002792	phosphorylation site [posttranslational modification]
1284663002793	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1284663002794	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805
1284663002795	putative active site [active]
1284663002796	YdjC motif; other site
1284663002797	Mg binding site [ion binding]; other site
1284663002798	putative homodimer interface [polypeptide binding]; other site
1284663002799	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
1284663002800	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1284663002801	MarR family; Region: MarR; pfam01047
1284663002802	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1284663002803	MarR family; Region: MarR_2; pfam12802
1284663002804	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663002805	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663002806	putative substrate translocation pore; other site
1284663002807	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1284663002808	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663002809	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663002810	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1284663002811	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1284663002812	HflX GTPase family; Region: HflX; cd01878
1284663002813	G1 box; other site
1284663002814	GTP/Mg2+ binding site [chemical binding]; other site
1284663002815	Switch I region; other site
1284663002816	G2 box; other site
1284663002817	G3 box; other site
1284663002818	Switch II region; other site
1284663002819	G4 box; other site
1284663002820	G5 box; other site
1284663002821	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
1284663002822	nudix motif; other site
1284663002823	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1284663002824	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1284663002825	catalytic core [active]
1284663002826	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1284663002827	catalytic core [active]
1284663002828	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1284663002829	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1284663002830	TrkA-N domain; Region: TrkA_N; pfam02254
1284663002831	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1284663002832	TrkA-C domain; Region: TrkA_C; pfam02080
1284663002833	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
1284663002834	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1284663002835	putative active site [active]
1284663002836	nucleotide binding site [chemical binding]; other site
1284663002837	nudix motif; other site
1284663002838	putative metal binding site [ion binding]; other site
1284663002839	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1284663002840	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1284663002841	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1284663002842	Part of AAA domain; Region: AAA_19; pfam13245
1284663002843	Family description; Region: UvrD_C_2; pfam13538
1284663002844	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
1284663002845	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1284663002846	FMN binding site [chemical binding]; other site
1284663002847	substrate binding site [chemical binding]; other site
1284663002848	putative catalytic residue [active]
1284663002849	pantothenate kinase; Provisional; Region: PRK05439
1284663002850	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1284663002851	ATP-binding site [chemical binding]; other site
1284663002852	CoA-binding site [chemical binding]; other site
1284663002853	Mg2+-binding site [ion binding]; other site
1284663002854	GMP synthase; Reviewed; Region: guaA; PRK00074
1284663002855	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1284663002856	AMP/PPi binding site [chemical binding]; other site
1284663002857	candidate oxyanion hole; other site
1284663002858	catalytic triad [active]
1284663002859	potential glutamine specificity residues [chemical binding]; other site
1284663002860	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1284663002861	ATP Binding subdomain [chemical binding]; other site
1284663002862	Dimerization subdomain; other site
1284663002863	stage V sporulation protein K; Region: spore_V_K; TIGR02881
1284663002864	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663002865	Walker A motif; other site
1284663002866	ATP binding site [chemical binding]; other site
1284663002867	Walker B motif; other site
1284663002868	arginine finger; other site
1284663002869	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1284663002870	Transposase; Region: HTH_Tnp_1; cl17663
1284663002871	Helix-turn-helix domain; Region: HTH_28; pfam13518
1284663002872	putative transposase OrfB; Reviewed; Region: PHA02517
1284663002873	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1284663002874	Helix-turn-helix domain; Region: HTH_38; pfam13936
1284663002875	Integrase core domain; Region: rve; pfam00665
1284663002876	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663002877	sequence-specific DNA binding site [nucleotide binding]; other site
1284663002878	salt bridge; other site
1284663002879	CAAX protease self-immunity; Region: Abi; pfam02517
1284663002880	Predicted transcriptional regulators [Transcription]; Region: COG1733
1284663002881	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1284663002882	Helix-turn-helix domain; Region: HTH_28; pfam13518
1284663002883	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1284663002884	Transposase; Region: HTH_Tnp_1; cl17663
1284663002885	Helix-turn-helix domain; Region: HTH_28; pfam13518
1284663002886	putative transposase OrfB; Reviewed; Region: PHA02517
1284663002887	HTH-like domain; Region: HTH_21; pfam13276
1284663002888	Integrase core domain; Region: rve; pfam00665
1284663002889	Integrase core domain; Region: rve_3; pfam13683
1284663002890	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1284663002891	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663002892	putative substrate translocation pore; other site
1284663002893	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1284663002894	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
1284663002895	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1284663002896	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
1284663002897	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1284663002898	catalytic triad [active]
1284663002899	catalytic triad [active]
1284663002900	oxyanion hole [active]
1284663002901	Predicted membrane protein [Function unknown]; Region: COG2261
1284663002902	Asp23 family; Region: Asp23; pfam03780
1284663002903	Asp23 family; Region: Asp23; pfam03780
1284663002904	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1284663002905	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1284663002906	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166
1284663002907	methionine cluster; other site
1284663002908	active site
1284663002909	phosphorylation site [posttranslational modification]
1284663002910	metal binding site [ion binding]; metal-binding site
1284663002911	Peptidase family M1; Region: Peptidase_M1; pfam01433
1284663002912	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
1284663002913	Zn binding site [ion binding]; other site
1284663002914	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
1284663002915	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1284663002916	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1284663002917	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1284663002918	ATP binding site [chemical binding]; other site
1284663002919	putative Mg++ binding site [ion binding]; other site
1284663002920	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
1284663002921	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1284663002922	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1284663002923	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1284663002924	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1284663002925	Int/Topo IB signature motif; other site
1284663002926	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1284663002927	catalytic core [active]
1284663002928	potential frameshift: common BLAST hit: Mucus-binding protein, LPXTG-motif cell wall anchor
1284663002929	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1284663002930	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663002931	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663002932	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663002933	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663002934	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663002935	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663002936	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663002937	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663002938	hypothetical protein; Provisional; Region: PRK06762
1284663002939	hypothetical protein; Provisional; Region: PRK06762
1284663002940	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1284663002941	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663002942	non-specific DNA binding site [nucleotide binding]; other site
1284663002943	salt bridge; other site
1284663002944	sequence-specific DNA binding site [nucleotide binding]; other site
1284663002945	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1284663002946	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663002947	non-specific DNA binding site [nucleotide binding]; other site
1284663002948	salt bridge; other site
1284663002949	sequence-specific DNA binding site [nucleotide binding]; other site
1284663002950	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1284663002951	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663002952	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663002953	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1284663002954	dimerization interface [polypeptide binding]; other site
1284663002955	FAD binding domain; Region: FAD_binding_2; pfam00890
1284663002956	Predicted oxidoreductase [General function prediction only]; Region: COG3573
1284663002957	FMN-binding domain; Region: FMN_bind; cl01081
1284663002958	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1284663002959	MarR family; Region: MarR_2; cl17246
1284663002960	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1284663002961	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1284663002962	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1284663002963	putative dimer interface [polypeptide binding]; other site
1284663002964	putative anticodon binding site; other site
1284663002965	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1284663002966	homodimer interface [polypeptide binding]; other site
1284663002967	motif 1; other site
1284663002968	motif 2; other site
1284663002969	active site
1284663002970	motif 3; other site
1284663002971	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
1284663002972	dimer interface [polypeptide binding]; other site
1284663002973	active site
1284663002974	Peptidase family C69; Region: Peptidase_C69; pfam03577
1284663002975	Helix-turn-helix domain; Region: HTH_28; pfam13518
1284663002976	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1284663002977	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1284663002978	ATP binding site [chemical binding]; other site
1284663002979	putative Mg++ binding site [ion binding]; other site
1284663002980	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1284663002981	nucleotide binding region [chemical binding]; other site
1284663002982	ATP-binding site [chemical binding]; other site
1284663002983	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1284663002984	HRDC domain; Region: HRDC; pfam00570
1284663002985	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1284663002986	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1284663002987	active site
1284663002988	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1284663002989	dimerization interface [polypeptide binding]; other site
1284663002990	putative DNA binding site [nucleotide binding]; other site
1284663002991	putative Zn2+ binding site [ion binding]; other site
1284663002992	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1284663002993	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1284663002994	YibE/F-like protein; Region: YibE_F; pfam07907
1284663002995	YibE/F-like protein; Region: YibE_F; cl02259
1284663002996	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
1284663002997	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663002998	Coenzyme A binding pocket [chemical binding]; other site
1284663002999	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1284663003000	catalytic core [active]
1284663003001	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1284663003002	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1284663003003	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1284663003004	active site pocket [active]
1284663003005	GntP family permease; Region: GntP_permease; pfam02447
1284663003006	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1284663003007	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1284663003008	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1284663003009	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1284663003010	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1284663003011	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1284663003012	transmembrane helices; other site
1284663003013	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1284663003014	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1284663003015	ligand binding site [chemical binding]; other site
1284663003016	NAD binding site [chemical binding]; other site
1284663003017	dimerization interface [polypeptide binding]; other site
1284663003018	catalytic site [active]
1284663003019	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663003020	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663003021	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1284663003022	dimerization interface [polypeptide binding]; other site
1284663003023	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
1284663003024	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1284663003025	metal binding site [ion binding]; metal-binding site
1284663003026	substrate binding pocket [chemical binding]; other site
1284663003027	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1284663003028	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1284663003029	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1284663003030	MFS/sugar transport protein; Region: MFS_2; pfam13347
1284663003031	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663003032	putative substrate translocation pore; other site
1284663003033	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1284663003034	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1284663003035	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1284663003036	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1284663003037	aspartate kinase I; Reviewed; Region: PRK08210
1284663003038	AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of  the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260
1284663003039	putative catalytic residues [active]
1284663003040	putative nucleotide binding site [chemical binding]; other site
1284663003041	putative aspartate binding site [chemical binding]; other site
1284663003042	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1284663003043	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1284663003044	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
1284663003045	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1284663003046	active site
1284663003047	dimer interface [polypeptide binding]; other site
1284663003048	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1284663003049	Ligand Binding Site [chemical binding]; other site
1284663003050	Molecular Tunnel; other site
1284663003051	Predicted membrane protein [Function unknown]; Region: COG4392
1284663003052	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1284663003053	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1284663003054	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1284663003055	DNA binding residues [nucleotide binding]
1284663003056	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663003057	putative substrate translocation pore; other site
1284663003058	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663003059	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1284663003060	DNA binding residues [nucleotide binding]
1284663003061	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1284663003062	putative dimer interface [polypeptide binding]; other site
1284663003063	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1284663003064	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
1284663003065	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1284663003066	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
1284663003067	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1284663003068	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1284663003069	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1284663003070	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1284663003071	DNA-binding site [nucleotide binding]; DNA binding site
1284663003072	RNA-binding motif; other site
1284663003073	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1284663003074	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1284663003075	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
1284663003076	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1284663003077	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1284663003078	active site
1284663003079	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1284663003080	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1284663003081	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1284663003082	Predicted transcriptional regulator [Transcription]; Region: COG1959
1284663003083	Transcriptional regulator; Region: Rrf2; pfam02082
1284663003084	acetolactate synthase; Reviewed; Region: PRK08617
1284663003085	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1284663003086	PYR/PP interface [polypeptide binding]; other site
1284663003087	dimer interface [polypeptide binding]; other site
1284663003088	TPP binding site [chemical binding]; other site
1284663003089	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1284663003090	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
1284663003091	TPP-binding site [chemical binding]; other site
1284663003092	dimer interface [polypeptide binding]; other site
1284663003093	lysine transporter; Provisional; Region: PRK10836
1284663003094	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1284663003095	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1284663003096	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1284663003097	Substrate-binding site [chemical binding]; other site
1284663003098	Substrate specificity [chemical binding]; other site
1284663003099	seryl-tRNA synthetase; Provisional; Region: PRK05431
1284663003100	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1284663003101	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1284663003102	dimer interface [polypeptide binding]; other site
1284663003103	active site
1284663003104	motif 1; other site
1284663003105	motif 2; other site
1284663003106	motif 3; other site
1284663003107	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
1284663003108	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1284663003109	Clp amino terminal domain; Region: Clp_N; pfam02861
1284663003110	Clp amino terminal domain; Region: Clp_N; pfam02861
1284663003111	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663003112	Walker A motif; other site
1284663003113	ATP binding site [chemical binding]; other site
1284663003114	Walker B motif; other site
1284663003115	arginine finger; other site
1284663003116	UvrB/uvrC motif; Region: UVR; pfam02151
1284663003117	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663003118	Walker A motif; other site
1284663003119	ATP binding site [chemical binding]; other site
1284663003120	Walker B motif; other site
1284663003121	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1284663003122	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663003123	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663003124	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1284663003125	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1284663003126	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1284663003127	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1284663003128	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
1284663003129	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1284663003130	RPB1 interaction site [polypeptide binding]; other site
1284663003131	RPB10 interaction site [polypeptide binding]; other site
1284663003132	RPB11 interaction site [polypeptide binding]; other site
1284663003133	RPB3 interaction site [polypeptide binding]; other site
1284663003134	RPB12 interaction site [polypeptide binding]; other site
1284663003135	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1284663003136	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1284663003137	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1284663003138	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1284663003139	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1284663003140	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1284663003141	cleft; other site
1284663003142	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
1284663003143	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1284663003144	DNA binding site [nucleotide binding]
1284663003145	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1284663003146	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1284663003147	S17 interaction site [polypeptide binding]; other site
1284663003148	S8 interaction site; other site
1284663003149	16S rRNA interaction site [nucleotide binding]; other site
1284663003150	streptomycin interaction site [chemical binding]; other site
1284663003151	23S rRNA interaction site [nucleotide binding]; other site
1284663003152	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1284663003153	30S ribosomal protein S7; Validated; Region: PRK05302
1284663003154	elongation factor G; Reviewed; Region: PRK12739
1284663003155	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1284663003156	G1 box; other site
1284663003157	putative GEF interaction site [polypeptide binding]; other site
1284663003158	GTP/Mg2+ binding site [chemical binding]; other site
1284663003159	Switch I region; other site
1284663003160	G2 box; other site
1284663003161	G3 box; other site
1284663003162	Switch II region; other site
1284663003163	G4 box; other site
1284663003164	G5 box; other site
1284663003165	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1284663003166	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1284663003167	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1284663003168	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1284663003169	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1284663003170	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1284663003171	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1284663003172	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1284663003173	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1284663003174	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1284663003175	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1284663003176	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1284663003177	putative translocon binding site; other site
1284663003178	protein-rRNA interface [nucleotide binding]; other site
1284663003179	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1284663003180	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1284663003181	G-X-X-G motif; other site
1284663003182	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1284663003183	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1284663003184	23S rRNA interface [nucleotide binding]; other site
1284663003185	5S rRNA interface [nucleotide binding]; other site
1284663003186	putative antibiotic binding site [chemical binding]; other site
1284663003187	L25 interface [polypeptide binding]; other site
1284663003188	L27 interface [polypeptide binding]; other site
1284663003189	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1284663003190	23S rRNA interface [nucleotide binding]; other site
1284663003191	putative translocon interaction site; other site
1284663003192	signal recognition particle (SRP54) interaction site; other site
1284663003193	L23 interface [polypeptide binding]; other site
1284663003194	trigger factor interaction site; other site
1284663003195	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1284663003196	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1284663003197	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1284663003198	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1284663003199	RNA binding site [nucleotide binding]; other site
1284663003200	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1284663003201	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1284663003202	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1284663003203	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1284663003204	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1284663003205	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1284663003206	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1284663003207	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1284663003208	5S rRNA interface [nucleotide binding]; other site
1284663003209	L27 interface [polypeptide binding]; other site
1284663003210	23S rRNA interface [nucleotide binding]; other site
1284663003211	L5 interface [polypeptide binding]; other site
1284663003212	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1284663003213	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1284663003214	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1284663003215	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1284663003216	23S rRNA binding site [nucleotide binding]; other site
1284663003217	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1284663003218	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1284663003219	SecY translocase; Region: SecY; pfam00344
1284663003220	adenylate kinase; Reviewed; Region: adk; PRK00279
1284663003221	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1284663003222	AMP-binding site [chemical binding]; other site
1284663003223	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1284663003224	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1284663003225	rRNA binding site [nucleotide binding]; other site
1284663003226	predicted 30S ribosome binding site; other site
1284663003227	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1284663003228	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1284663003229	30S ribosomal protein S11; Validated; Region: PRK05309
1284663003230	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1284663003231	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1284663003232	alphaNTD homodimer interface [polypeptide binding]; other site
1284663003233	alphaNTD - beta interaction site [polypeptide binding]; other site
1284663003234	alphaNTD - beta' interaction site [polypeptide binding]; other site
1284663003235	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1284663003236	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1284663003237	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1284663003238	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1284663003239	substrate binding pocket [chemical binding]; other site
1284663003240	chain length determination region; other site
1284663003241	substrate-Mg2+ binding site; other site
1284663003242	catalytic residues [active]
1284663003243	aspartate-rich region 1; other site
1284663003244	active site lid residues [active]
1284663003245	aspartate-rich region 2; other site
1284663003246	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
1284663003247	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
1284663003248	trimer interface [polypeptide binding]; other site
1284663003249	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1284663003250	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1284663003251	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
1284663003252	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
1284663003253	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1284663003254	ApbE family; Region: ApbE; pfam02424
1284663003255	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
1284663003256	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1284663003257	Walker A/P-loop; other site
1284663003258	ATP binding site [chemical binding]; other site
1284663003259	Q-loop/lid; other site
1284663003260	ABC transporter signature motif; other site
1284663003261	Walker B; other site
1284663003262	D-loop; other site
1284663003263	H-loop/switch region; other site
1284663003264	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
1284663003265	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1284663003266	Walker A/P-loop; other site
1284663003267	ATP binding site [chemical binding]; other site
1284663003268	Q-loop/lid; other site
1284663003269	ABC transporter signature motif; other site
1284663003270	Walker B; other site
1284663003271	D-loop; other site
1284663003272	H-loop/switch region; other site
1284663003273	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1284663003274	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1284663003275	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1284663003276	dimerization interface 3.5A [polypeptide binding]; other site
1284663003277	active site
1284663003278	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1284663003279	23S rRNA interface [nucleotide binding]; other site
1284663003280	L3 interface [polypeptide binding]; other site
1284663003281	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1284663003282	EDD domain protein, DegV family; Region: DegV; TIGR00762
1284663003283	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1284663003284	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
1284663003285	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1284663003286	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1284663003287	TPP-binding site [chemical binding]; other site
1284663003288	dimer interface [polypeptide binding]; other site
1284663003289	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1284663003290	PYR/PP interface [polypeptide binding]; other site
1284663003291	dimer interface [polypeptide binding]; other site
1284663003292	TPP binding site [chemical binding]; other site
1284663003293	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1284663003294	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1284663003295	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1284663003296	shikimate binding site; other site
1284663003297	NAD(P) binding site [chemical binding]; other site
1284663003298	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
1284663003299	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
1284663003300	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1284663003301	active site
1284663003302	dimer interface [polypeptide binding]; other site
1284663003303	metal binding site [ion binding]; metal-binding site
1284663003304	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1284663003305	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1284663003306	transmembrane helices; other site
1284663003307	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1284663003308	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
1284663003309	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
1284663003310	Cupin domain; Region: Cupin_2; pfam07883
1284663003311	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1284663003312	triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125
1284663003313	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1284663003314	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1284663003315	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1284663003316	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1284663003317	ABC-ATPase subunit  interface; other site
1284663003318	dimer interface [polypeptide binding]; other site
1284663003319	putative PBP binding regions; other site
1284663003320	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1284663003321	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1284663003322	metal binding site [ion binding]; metal-binding site
1284663003323	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1284663003324	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1284663003325	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1284663003326	NAD binding site [chemical binding]; other site
1284663003327	dimer interface [polypeptide binding]; other site
1284663003328	substrate binding site [chemical binding]; other site
1284663003329	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1284663003330	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1284663003331	transmembrane helices; other site
1284663003332	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1284663003333	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1284663003334	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1284663003335	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1284663003336	Malic enzyme, NAD binding domain; Region: Malic_M; smart00919
1284663003337	NAD(P) binding pocket [chemical binding]; other site
1284663003338	[citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124
1284663003339	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
1284663003340	putative active site [active]
1284663003341	(T/H)XGH motif; other site
1284663003342	citrate lyase subunit gamma; Provisional; Region: PRK13253
1284663003343	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1284663003344	citrate lyase, alpha subunit; Region: citF; TIGR01584
1284663003345	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1284663003346	Helix-turn-helix domain; Region: HTH_38; pfam13936
1284663003347	Homeodomain-like domain; Region: HTH_32; pfam13565
1284663003348	Integrase core domain; Region: rve; pfam00665
1284663003349	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1284663003350	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663003351	non-specific DNA binding site [nucleotide binding]; other site
1284663003352	salt bridge; other site
1284663003353	sequence-specific DNA binding site [nucleotide binding]; other site
1284663003354	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1284663003355	MULE transposase domain; Region: MULE; pfam10551
1284663003356	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1284663003357	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1284663003358	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1284663003359	putative active site [active]
1284663003360	putative NTP binding site [chemical binding]; other site
1284663003361	putative nucleic acid binding site [nucleotide binding]; other site
1284663003362	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1284663003363	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1284663003364	Class II fumarases; Region: Fumarase_classII; cd01362
1284663003365	active site
1284663003366	tetramer interface [polypeptide binding]; other site
1284663003367	L-aspartate oxidase; Provisional; Region: PRK06175
1284663003368	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
1284663003369	L-aspartate oxidase; Provisional; Region: PRK06175
1284663003370	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802
1284663003371	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663003372	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663003373	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1284663003374	dimerization interface [polypeptide binding]; other site
1284663003375	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663003376	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663003377	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1284663003378	dimerization interface [polypeptide binding]; other site
1284663003379	malate dehydrogenase; Provisional; Region: PRK13529
1284663003380	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1284663003381	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1284663003382	NAD(P) binding site [chemical binding]; other site
1284663003383	Membrane transport protein; Region: Mem_trans; cl09117
1284663003384	amino acid transporter; Region: 2A0306; TIGR00909
1284663003385	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1284663003386	Predicted membrane protein [Function unknown]; Region: COG4684
1284663003387	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1284663003388	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1284663003389	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1284663003390	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1284663003391	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1284663003392	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1284663003393	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1284663003394	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1284663003395	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1284663003396	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663003397	Walker A/P-loop; other site
1284663003398	ATP binding site [chemical binding]; other site
1284663003399	Q-loop/lid; other site
1284663003400	ABC transporter signature motif; other site
1284663003401	Walker B; other site
1284663003402	D-loop; other site
1284663003403	H-loop/switch region; other site
1284663003404	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
1284663003405	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1284663003406	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
1284663003407	Walker A/P-loop; other site
1284663003408	ATP binding site [chemical binding]; other site
1284663003409	Q-loop/lid; other site
1284663003410	ABC transporter signature motif; other site
1284663003411	Walker B; other site
1284663003412	D-loop; other site
1284663003413	H-loop/switch region; other site
1284663003414	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
1284663003415	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1284663003416	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1284663003417	substrate binding pocket [chemical binding]; other site
1284663003418	chain length determination region; other site
1284663003419	substrate-Mg2+ binding site; other site
1284663003420	catalytic residues [active]
1284663003421	aspartate-rich region 1; other site
1284663003422	active site lid residues [active]
1284663003423	aspartate-rich region 2; other site
1284663003424	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1284663003425	UbiA prenyltransferase family; Region: UbiA; pfam01040
1284663003426	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1284663003427	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1284663003428	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1284663003429	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1284663003430	active site
1284663003431	hypothetical protein; Provisional; Region: PRK04164
1284663003432	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1284663003433	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1284663003434	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1284663003435	Part of AAA domain; Region: AAA_19; pfam13245
1284663003436	Family description; Region: UvrD_C_2; pfam13538
1284663003437	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1284663003438	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1284663003439	nucleotide binding pocket [chemical binding]; other site
1284663003440	K-X-D-G motif; other site
1284663003441	catalytic site [active]
1284663003442	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1284663003443	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1284663003444	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1284663003445	Dimer interface [polypeptide binding]; other site
1284663003446	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
1284663003447	putative dimer interface [polypeptide binding]; other site
1284663003448	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
1284663003449	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
1284663003450	putative dimer interface [polypeptide binding]; other site
1284663003451	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1284663003452	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1284663003453	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1284663003454	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1284663003455	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1284663003456	GatB domain; Region: GatB_Yqey; pfam02637
1284663003457	putative lipid kinase; Reviewed; Region: PRK13055
1284663003458	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1284663003459	TRAM domain; Region: TRAM; pfam01938
1284663003460	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1284663003461	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1284663003462	S-adenosylmethionine binding site [chemical binding]; other site
1284663003463	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663003464	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663003465	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1284663003466	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1284663003467	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1284663003468	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1284663003469	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1284663003470	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1284663003471	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1284663003472	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1284663003473	putative active site [active]
1284663003474	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419
1284663003475	active site
1284663003476	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1284663003477	DNA-binding site [nucleotide binding]; DNA binding site
1284663003478	RNA-binding motif; other site
1284663003479	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1284663003480	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1284663003481	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1284663003482	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1284663003483	ATP binding site [chemical binding]; other site
1284663003484	putative Mg++ binding site [ion binding]; other site
1284663003485	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1284663003486	nucleotide binding region [chemical binding]; other site
1284663003487	ATP-binding site [chemical binding]; other site
1284663003488	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1284663003489	Ligand Binding Site [chemical binding]; other site
1284663003490	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1284663003491	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1284663003492	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1284663003493	glutamate dehydrogenase; Provisional; Region: PRK09414
1284663003494	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1284663003495	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1284663003496	NAD(P) binding site [chemical binding]; other site
1284663003497	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1284663003498	Beta-lactamase; Region: Beta-lactamase; pfam00144
1284663003499	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1284663003500	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1284663003501	active site
1284663003502	homodimer interface [polypeptide binding]; other site
1284663003503	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1284663003504	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1284663003505	amphipathic channel; other site
1284663003506	Asn-Pro-Ala signature motifs; other site
1284663003507	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1284663003508	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1284663003509	UDP-galactopyranose mutase; Region: GLF; pfam03275
1284663003510	Chain length determinant protein; Region: Wzz; cl15801
1284663003511	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1284663003512	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1284663003513	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
1284663003514	UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922
1284663003515	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1284663003516	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1284663003517	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1284663003518	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1284663003519	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
1284663003520	Probable Catalytic site; other site
1284663003521	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1284663003522	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1284663003523	glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171
1284663003524	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
1284663003525	active site
1284663003526	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663003527	NAD(P) binding site [chemical binding]; other site
1284663003528	active site
1284663003529	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663003530	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1284663003531	active site
1284663003532	DNA binding site [nucleotide binding]
1284663003533	Int/Topo IB signature motif; other site
1284663003534	Chain length determinant protein; Region: Wzz; cl15801
1284663003535	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1284663003536	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1284663003537	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1284663003538	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663003539	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1284663003540	NAD(P) binding site [chemical binding]; other site
1284663003541	active site
1284663003542	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1284663003543	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1284663003544	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1284663003545	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1284663003546	putative ADP-binding pocket [chemical binding]; other site
1284663003547	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1284663003548	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1284663003549	putative ADP-binding pocket [chemical binding]; other site
1284663003550	Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111
1284663003551	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1284663003552	active site
1284663003553	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1284663003554	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1284663003555	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1284663003556	RelB antitoxin; Region: RelB; cl01171
1284663003557	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
1284663003558	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1284663003559	Helix-turn-helix domain; Region: HTH_38; pfam13936
1284663003560	Integrase core domain; Region: rve; pfam00665
1284663003561	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1284663003562	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1284663003563	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
1284663003564	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
1284663003565	RNAase interaction site [polypeptide binding]; other site
1284663003566	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1284663003567	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
1284663003568	Probable Catalytic site; other site
1284663003569	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1284663003570	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
1284663003571	Probable Catalytic site; other site
1284663003572	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1284663003573	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1284663003574	UDP-galactopyranose mutase; Region: GLF; pfam03275
1284663003575	potential frameshift: common BLAST hit: cps3D
1284663003576	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
1284663003577	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1284663003578	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
1284663003579	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1284663003580	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1284663003581	legume lectins; Region: lectin_L-type; cd01951
1284663003582	homotetramer interaction site [polypeptide binding]; other site
1284663003583	carbohydrate binding site [chemical binding]; other site
1284663003584	metal binding site [ion binding]; metal-binding site
1284663003585	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663003586	MucBP domain; Region: MucBP; pfam06458
1284663003587	MucBP domain; Region: MucBP; pfam06458
1284663003588	MucBP domain; Region: MucBP; pfam06458
1284663003589	MarR family; Region: MarR; pfam01047
1284663003590	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1284663003591	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1284663003592	potential frameshift: common BLAST hit: rfbP2
1284663003593	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1284663003594	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
1284663003595	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1284663003596	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1284663003597	recombination regulator RecX; Provisional; Region: recX; PRK14135
1284663003598	hypothetical protein; Provisional; Region: PRK13662
1284663003599	NlpC/P60 family; Region: NLPC_P60; pfam00877
1284663003600	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1284663003601	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663003602	non-specific DNA binding site [nucleotide binding]; other site
1284663003603	salt bridge; other site
1284663003604	sequence-specific DNA binding site [nucleotide binding]; other site
1284663003605	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046
1284663003606	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1284663003607	dimer interface [polypeptide binding]; other site
1284663003608	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1284663003609	NAD binding site [chemical binding]; other site
1284663003610	substrate binding site [chemical binding]; other site
1284663003611	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1284663003612	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1284663003613	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1284663003614	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
1284663003615	active site
1284663003616	nucleotide binding site [chemical binding]; other site
1284663003617	HIGH motif; other site
1284663003618	KMSKS motif; other site
1284663003619	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1284663003620	GntP family permease; Region: GntP_permease; pfam02447
1284663003621	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1284663003622	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1284663003623	N- and C-terminal domain interface [polypeptide binding]; other site
1284663003624	active site
1284663003625	catalytic site [active]
1284663003626	metal binding site [ion binding]; metal-binding site
1284663003627	carbohydrate binding site [chemical binding]; other site
1284663003628	ATP binding site [chemical binding]; other site
1284663003629	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1284663003630	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
1284663003631	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1284663003632	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1284663003633	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1284663003634	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1284663003635	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1284663003636	G1 box; other site
1284663003637	putative GEF interaction site [polypeptide binding]; other site
1284663003638	GTP/Mg2+ binding site [chemical binding]; other site
1284663003639	Switch I region; other site
1284663003640	G2 box; other site
1284663003641	G3 box; other site
1284663003642	Switch II region; other site
1284663003643	G4 box; other site
1284663003644	G5 box; other site
1284663003645	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1284663003646	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663003647	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663003648	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663003649	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663003650	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1284663003651	dimerization interface [polypeptide binding]; other site
1284663003652	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1284663003653	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
1284663003654	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1284663003655	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1284663003656	peptide binding site [polypeptide binding]; other site
1284663003657	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1284663003658	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663003659	dimer interface [polypeptide binding]; other site
1284663003660	conserved gate region; other site
1284663003661	putative PBP binding loops; other site
1284663003662	ABC-ATPase subunit interface; other site
1284663003663	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1284663003664	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663003665	dimer interface [polypeptide binding]; other site
1284663003666	conserved gate region; other site
1284663003667	putative PBP binding loops; other site
1284663003668	ABC-ATPase subunit interface; other site
1284663003669	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1284663003670	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1284663003671	Walker A/P-loop; other site
1284663003672	ATP binding site [chemical binding]; other site
1284663003673	Q-loop/lid; other site
1284663003674	ABC transporter signature motif; other site
1284663003675	Walker B; other site
1284663003676	D-loop; other site
1284663003677	H-loop/switch region; other site
1284663003678	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1284663003679	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1284663003680	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1284663003681	Walker A/P-loop; other site
1284663003682	ATP binding site [chemical binding]; other site
1284663003683	Q-loop/lid; other site
1284663003684	ABC transporter signature motif; other site
1284663003685	Walker B; other site
1284663003686	D-loop; other site
1284663003687	H-loop/switch region; other site
1284663003688	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1284663003689	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1284663003690	MarR family; Region: MarR_2; pfam12802
1284663003691	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
1284663003692	Int/Topo IB signature motif; other site
1284663003693	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663003694	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1284663003695	Walker A motif; other site
1284663003696	ATP binding site [chemical binding]; other site
1284663003697	Walker B motif; other site
1284663003698	arginine finger; other site
1284663003699	UvrB/uvrC motif; Region: UVR; pfam02151
1284663003700	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663003701	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1284663003702	Walker A motif; other site
1284663003703	ATP binding site [chemical binding]; other site
1284663003704	Walker B motif; other site
1284663003705	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1284663003706	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1284663003707	dimerization domain swap beta strand [polypeptide binding]; other site
1284663003708	regulatory protein interface [polypeptide binding]; other site
1284663003709	active site
1284663003710	regulatory phosphorylation site [posttranslational modification]; other site
1284663003711	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1284663003712	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1284663003713	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1284663003714	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1284663003715	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1284663003716	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
1284663003717	putative ADP-binding pocket [chemical binding]; other site
1284663003718	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1284663003719	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1284663003720	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
1284663003721	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1284663003722	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1284663003723	aromatic amino acid aminotransferase; Validated; Region: PRK07309
1284663003724	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1284663003725	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663003726	homodimer interface [polypeptide binding]; other site
1284663003727	catalytic residue [active]
1284663003728	Protein of unknown function (DUF1797); Region: DUF1797; pfam08796
1284663003729	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1284663003730	Sulfatase; Region: Sulfatase; pfam00884
1284663003731	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1284663003732	active site
1284663003733	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1284663003734	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663003735	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1284663003736	Coenzyme A binding pocket [chemical binding]; other site
1284663003737	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1284663003738	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1284663003739	Cupin domain; Region: Cupin_2; pfam07883
1284663003740	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1284663003741	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1284663003742	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1284663003743	potential frameshift: common BLAST hit: Transport protein
1284663003744	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663003745	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663003746	putative substrate translocation pore; other site
1284663003747	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1284663003748	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1284663003749	nucleotide binding site [chemical binding]; other site
1284663003750	butyrate kinase; Region: butyr_kinase; TIGR02707
1284663003751	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
1284663003752	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1284663003753	Ferrochelatase; Region: Ferrochelatase; pfam00762
1284663003754	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1284663003755	C-terminal domain interface [polypeptide binding]; other site
1284663003756	active site
1284663003757	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1284663003758	active site
1284663003759	N-terminal domain interface [polypeptide binding]; other site
1284663003760	S-methylmethionine transporter; Provisional; Region: PRK11387
1284663003761	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1284663003762	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
1284663003763	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1284663003764	potential frameshift: common BLAST hit: tagE1
1284663003765	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1284663003766	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1284663003767	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1284663003768	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1284663003769	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1284663003770	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1284663003771	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1284663003772	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1284663003773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663003774	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663003775	putative substrate translocation pore; other site
1284663003776	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663003777	potential frameshift: common BLAST hit: sdr
1284663003778	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1284663003779	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1284663003780	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1284663003781	potential frameshift: common BLAST hit: tagE3
1284663003782	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1284663003783	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1284663003784	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1284663003785	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1284663003786	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
1284663003787	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1284663003788	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1284663003789	active site
1284663003790	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1284663003791	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1284663003792	HIGH motif; other site
1284663003793	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1284663003794	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1284663003795	active site
1284663003796	KMSKS motif; other site
1284663003797	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1284663003798	tRNA binding surface [nucleotide binding]; other site
1284663003799	stage V sporulation protein B; Region: spore_V_B; TIGR02900
1284663003800	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1284663003801	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1284663003802	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1284663003803	RNA binding surface [nucleotide binding]; other site
1284663003804	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1284663003805	active site
1284663003806	uracil binding [chemical binding]; other site
1284663003807	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1284663003808	putative substrate binding site [chemical binding]; other site
1284663003809	putative ATP binding site [chemical binding]; other site
1284663003810	dipeptidase PepV; Reviewed; Region: PRK07318
1284663003811	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1284663003812	active site
1284663003813	metal binding site [ion binding]; metal-binding site
1284663003814	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1284663003815	Ligand Binding Site [chemical binding]; other site
1284663003816	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1284663003817	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663003818	Walker A/P-loop; other site
1284663003819	ATP binding site [chemical binding]; other site
1284663003820	Q-loop/lid; other site
1284663003821	ABC transporter signature motif; other site
1284663003822	Walker B; other site
1284663003823	D-loop; other site
1284663003824	H-loop/switch region; other site
1284663003825	TOBE domain; Region: TOBE_2; pfam08402
1284663003826	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663003827	dimer interface [polypeptide binding]; other site
1284663003828	conserved gate region; other site
1284663003829	putative PBP binding loops; other site
1284663003830	ABC-ATPase subunit interface; other site
1284663003831	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1284663003832	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663003833	dimer interface [polypeptide binding]; other site
1284663003834	conserved gate region; other site
1284663003835	putative PBP binding loops; other site
1284663003836	ABC-ATPase subunit interface; other site
1284663003837	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1284663003838	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1284663003839	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1284663003840	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1284663003841	active site
1284663003842	catalytic site [active]
1284663003843	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1284663003844	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1284663003845	Substrate-binding site [chemical binding]; other site
1284663003846	Substrate specificity [chemical binding]; other site
1284663003847	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1284663003848	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
1284663003849	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1284663003850	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
1284663003851	Predicted membrane protein [Function unknown]; Region: COG1511
1284663003852	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1284663003853	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1284663003854	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1284663003855	Walker A/P-loop; other site
1284663003856	ATP binding site [chemical binding]; other site
1284663003857	Q-loop/lid; other site
1284663003858	ABC transporter signature motif; other site
1284663003859	Walker B; other site
1284663003860	D-loop; other site
1284663003861	H-loop/switch region; other site
1284663003862	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663003863	Walker A/P-loop; other site
1284663003864	ATP binding site [chemical binding]; other site
1284663003865	ABC transporter; Region: ABC_tran; pfam00005
1284663003866	Q-loop/lid; other site
1284663003867	ABC transporter signature motif; other site
1284663003868	Walker B; other site
1284663003869	D-loop; other site
1284663003870	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1284663003871	H-loop/switch region; other site
1284663003872	LytTr DNA-binding domain; Region: LytTR; pfam04397
1284663003873	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1284663003874	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1284663003875	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1284663003876	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1284663003877	DNA binding residues [nucleotide binding]
1284663003878	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663003879	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1284663003880	NAD(P) binding site [chemical binding]; other site
1284663003881	active site
1284663003882	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1284663003883	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1284663003884	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1284663003885	active site
1284663003886	motif I; other site
1284663003887	motif II; other site
1284663003888	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1284663003889	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1284663003890	ATP binding site [chemical binding]; other site
1284663003891	Mg2+ binding site [ion binding]; other site
1284663003892	G-X-G motif; other site
1284663003893	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1284663003894	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1284663003895	active site
1284663003896	phosphorylation site [posttranslational modification]
1284663003897	intermolecular recognition site; other site
1284663003898	dimerization interface [polypeptide binding]; other site
1284663003899	LytTr DNA-binding domain; Region: LytTR; pfam04397
1284663003900	CAAX protease self-immunity; Region: Abi; pfam02517
1284663003901	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1284663003902	MarR family; Region: MarR; pfam01047
1284663003903	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
1284663003904	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663003905	Walker A/P-loop; other site
1284663003906	ATP binding site [chemical binding]; other site
1284663003907	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
1284663003908	Q-loop/lid; other site
1284663003909	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663003910	ABC transporter signature motif; other site
1284663003911	Walker B; other site
1284663003912	D-loop; other site
1284663003913	H-loop/switch region; other site
1284663003914	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663003915	Walker A/P-loop; other site
1284663003916	ATP binding site [chemical binding]; other site
1284663003917	Q-loop/lid; other site
1284663003918	ABC transporter signature motif; other site
1284663003919	Walker B; other site
1284663003920	D-loop; other site
1284663003921	H-loop/switch region; other site
1284663003922	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1284663003923	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1284663003924	Int/Topo IB signature motif; other site
1284663003925	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
1284663003926	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1284663003927	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1284663003928	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1284663003929	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663003930	non-specific DNA binding site [nucleotide binding]; other site
1284663003931	salt bridge; other site
1284663003932	sequence-specific DNA binding site [nucleotide binding]; other site
1284663003933	Domain of unknown function (DUF771); Region: DUF771; pfam05595
1284663003934	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
1284663003935	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1284663003936	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1284663003937	putative Mg++ binding site [ion binding]; other site
1284663003938	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1284663003939	nucleotide binding region [chemical binding]; other site
1284663003940	ATP-binding site [chemical binding]; other site
1284663003941	phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618
1284663003942	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
1284663003943	polymerase nucleotide-binding site; other site
1284663003944	DNA-binding residues [nucleotide binding]; DNA binding site
1284663003945	nucleotide binding site [chemical binding]; other site
1284663003946	primase nucleotide-binding site [nucleotide binding]; other site
1284663003947	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
1284663003948	Virulence-associated protein E; Region: VirE; pfam05272
1284663003949	VRR-NUC domain; Region: VRR_NUC; pfam08774
1284663003950	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442
1284663003951	YfbU domain; Region: YfbU; cl01137
1284663003952	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
1284663003953	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
1284663003954	Phage-related protein [Function unknown]; Region: COG4695; cl01923
1284663003955	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
1284663003956	oligomer interface [polypeptide binding]; other site
1284663003957	active site residues [active]
1284663003958	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1284663003959	Phage capsid family; Region: Phage_capsid; pfam05065
1284663003960	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
1284663003961	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
1284663003962	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
1284663003963	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
1284663003964	Phage tail protein; Region: Sipho_tail; cl17486
1284663003965	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
1284663003966	surface protein repeat Ser-Ala-175; Region: SerAla_Lrha_rpt; TIGR04319
1284663003967	Protein of unknown function (DUF1617); Region: DUF1617; pfam07761
1284663003968	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
1284663003969	active site
1284663003970	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1284663003971	Bacterial SH3 domain; Region: SH3_5; pfam08460
1284663003972	Predicted membrane protein [Function unknown]; Region: COG2246
1284663003973	GtrA-like protein; Region: GtrA; pfam04138
1284663003974	hypothetical protein; Provisional; Region: PRK13673
1284663003975	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
1284663003976	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
1284663003977	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1284663003978	FAD binding site [chemical binding]; other site
1284663003979	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1284663003980	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1284663003981	THF binding site; other site
1284663003982	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1284663003983	substrate binding site [chemical binding]; other site
1284663003984	THF binding site; other site
1284663003985	zinc-binding site [ion binding]; other site
1284663003986	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
1284663003987	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
1284663003988	ATP-sulfurylase; Region: ATPS; cd00517
1284663003989	active site
1284663003990	HXXH motif; other site
1284663003991	flexible loop; other site
1284663003992	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1284663003993	ligand-binding site [chemical binding]; other site
1284663003994	potential frameshift: common BLAST hit: Phosphoesterase, DHH family
1284663003995	DHH family; Region: DHH; pfam01368
1284663003996	DHH family; Region: DHH; pfam01368
1284663003997	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1284663003998	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
1284663003999	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
1284663004000	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1284663004001	TrkA-C domain; Region: TrkA_C; pfam02080
1284663004002	TrkA-C domain; Region: TrkA_C; pfam02080
1284663004003	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1284663004004	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1284663004005	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1284663004006	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
1284663004007	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1284663004008	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
1284663004009	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1284663004010	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1284663004011	active site
1284663004012	HIGH motif; other site
1284663004013	KMSK motif region; other site
1284663004014	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1284663004015	tRNA binding surface [nucleotide binding]; other site
1284663004016	anticodon binding site; other site
1284663004017	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1284663004018	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1284663004019	Walker A/P-loop; other site
1284663004020	ATP binding site [chemical binding]; other site
1284663004021	Q-loop/lid; other site
1284663004022	ABC transporter signature motif; other site
1284663004023	Walker B; other site
1284663004024	D-loop; other site
1284663004025	H-loop/switch region; other site
1284663004026	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1284663004027	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1284663004028	FtsX-like permease family; Region: FtsX; pfam02687
1284663004029	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1284663004030	Transcriptional antiterminator [Transcription]; Region: COG3933
1284663004031	PRD domain; Region: PRD; pfam00874
1284663004032	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
1284663004033	PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255
1284663004034	active site
1284663004035	methionine cluster; other site
1284663004036	phosphorylation site [posttranslational modification]
1284663004037	metal binding site [ion binding]; metal-binding site
1284663004038	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1284663004039	active site
1284663004040	P-loop; other site
1284663004041	phosphorylation site [posttranslational modification]
1284663004042	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1284663004043	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1284663004044	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1284663004045	beta-galactosidase; Region: BGL; TIGR03356
1284663004046	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663004047	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663004048	putative substrate translocation pore; other site
1284663004049	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1284663004050	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1284663004051	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
1284663004052	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1284663004053	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1284663004054	DNA-binding site [nucleotide binding]; DNA binding site
1284663004055	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1284663004056	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663004057	homodimer interface [polypeptide binding]; other site
1284663004058	catalytic residue [active]
1284663004059	LysE type translocator; Region: LysE; cl00565
1284663004060	transaminase; Validated; Region: PRK07324
1284663004061	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1284663004062	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663004063	homodimer interface [polypeptide binding]; other site
1284663004064	catalytic residue [active]
1284663004065	Arginine repressor [Transcription]; Region: ArgR; COG1438
1284663004066	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1284663004067	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1284663004068	Transglycosylase; Region: Transgly; pfam00912
1284663004069	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1284663004070	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1284663004071	hypothetical protein; Provisional; Region: PRK13676
1284663004072	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1284663004073	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1284663004074	active site
1284663004075	metal binding site [ion binding]; metal-binding site
1284663004076	DNA binding site [nucleotide binding]
1284663004077	Uncharacterized conserved protein [Function unknown]; Region: COG4717
1284663004078	Uncharacterized conserved protein [Function unknown]; Region: COG4717
1284663004079	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1284663004080	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1284663004081	generic binding surface II; other site
1284663004082	generic binding surface I; other site
1284663004083	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1284663004084	Zn2+ binding site [ion binding]; other site
1284663004085	Mg2+ binding site [ion binding]; other site
1284663004086	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
1284663004087	Active site serine [active]
1284663004088	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663004089	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663004090	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1284663004091	dimerization interface [polypeptide binding]; other site
1284663004092	Predicted flavoprotein [General function prediction only]; Region: COG0431
1284663004093	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1284663004094	Predicted flavoprotein [General function prediction only]; Region: COG0431
1284663004095	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1284663004096	FMN-binding domain; Region: FMN_bind; cl01081
1284663004097	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844
1284663004098	L-aspartate oxidase; Provisional; Region: PRK06175
1284663004099	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
1284663004100	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1284663004101	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1284663004102	Ligand binding site; other site
1284663004103	Putative Catalytic site; other site
1284663004104	DXD motif; other site
1284663004105	conserved hypothetical integral membrane protein; Region: TIGR03766
1284663004106	potential frameshift: common BLAST hit: Phosphohydrolase, MutT/NudX family
1284663004107	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
1284663004108	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1284663004109	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1284663004110	catalytic motif [active]
1284663004111	Zn binding site [ion binding]; other site
1284663004112	RibD C-terminal domain; Region: RibD_C; cl17279
1284663004113	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1284663004114	Lumazine binding domain; Region: Lum_binding; pfam00677
1284663004115	Lumazine binding domain; Region: Lum_binding; pfam00677
1284663004116	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1284663004117	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1284663004118	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1284663004119	dimerization interface [polypeptide binding]; other site
1284663004120	active site
1284663004121	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1284663004122	homopentamer interface [polypeptide binding]; other site
1284663004123	active site
1284663004124	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
1284663004125	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1284663004126	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1284663004127	ligand binding site [chemical binding]; other site
1284663004128	flexible hinge region; other site
1284663004129	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1284663004130	non-specific DNA interactions [nucleotide binding]; other site
1284663004131	DNA binding site [nucleotide binding]
1284663004132	sequence specific DNA binding site [nucleotide binding]; other site
1284663004133	putative cAMP binding site [chemical binding]; other site
1284663004134	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663004135	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1284663004136	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1284663004137	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1284663004138	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1284663004139	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1284663004140	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1284663004141	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
1284663004142	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1284663004143	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1284663004144	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
1284663004145	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
1284663004146	SurA N-terminal domain; Region: SurA_N; pfam09312
1284663004147	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1284663004148	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1284663004149	HIT family signature motif; other site
1284663004150	catalytic residue [active]
1284663004151	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1284663004152	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1284663004153	Walker A/P-loop; other site
1284663004154	ATP binding site [chemical binding]; other site
1284663004155	Q-loop/lid; other site
1284663004156	ABC transporter signature motif; other site
1284663004157	Walker B; other site
1284663004158	D-loop; other site
1284663004159	H-loop/switch region; other site
1284663004160	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
1284663004161	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1284663004162	active site
1284663004163	substrate binding site [chemical binding]; other site
1284663004164	ATP binding site [chemical binding]; other site
1284663004165	Phosphotransferase enzyme family; Region: APH; pfam01636
1284663004166	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1284663004167	S-adenosylmethionine binding site [chemical binding]; other site
1284663004168	Predicted small secreted protein [Function unknown]; Region: COG5584
1284663004169	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1284663004170	putative tRNA-binding site [nucleotide binding]; other site
1284663004171	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1284663004172	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1284663004173	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
1284663004174	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1284663004175	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1284663004176	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1284663004177	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1284663004178	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1284663004179	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1284663004180	G1 box; other site
1284663004181	GTP/Mg2+ binding site [chemical binding]; other site
1284663004182	Switch I region; other site
1284663004183	G2 box; other site
1284663004184	G3 box; other site
1284663004185	Switch II region; other site
1284663004186	G4 box; other site
1284663004187	G5 box; other site
1284663004188	Nucleoside recognition; Region: Gate; pfam07670
1284663004189	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1284663004190	Nucleoside recognition; Region: Gate; pfam07670
1284663004191	FeoA domain; Region: FeoA; pfam04023
1284663004192	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1284663004193	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1284663004194	Walker A/P-loop; other site
1284663004195	ATP binding site [chemical binding]; other site
1284663004196	Q-loop/lid; other site
1284663004197	ABC transporter signature motif; other site
1284663004198	Walker B; other site
1284663004199	D-loop; other site
1284663004200	H-loop/switch region; other site
1284663004201	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1284663004202	FeS assembly protein SufD; Region: sufD; TIGR01981
1284663004203	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1284663004204	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1284663004205	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1284663004206	catalytic residue [active]
1284663004207	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1284663004208	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1284663004209	trimerization site [polypeptide binding]; other site
1284663004210	active site
1284663004211	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1284663004212	FeS assembly protein SufB; Region: sufB; TIGR01980
1284663004213	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1284663004214	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663004215	non-specific DNA binding site [nucleotide binding]; other site
1284663004216	salt bridge; other site
1284663004217	sequence-specific DNA binding site [nucleotide binding]; other site
1284663004218	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1284663004219	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1284663004220	DNA polymerase I; Provisional; Region: PRK05755
1284663004221	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1284663004222	active site
1284663004223	metal binding site 1 [ion binding]; metal-binding site
1284663004224	putative 5' ssDNA interaction site; other site
1284663004225	metal binding site 3; metal-binding site
1284663004226	metal binding site 2 [ion binding]; metal-binding site
1284663004227	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1284663004228	putative DNA binding site [nucleotide binding]; other site
1284663004229	putative metal binding site [ion binding]; other site
1284663004230	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1284663004231	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1284663004232	active site
1284663004233	DNA binding site [nucleotide binding]
1284663004234	catalytic site [active]
1284663004235	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1284663004236	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1284663004237	DNA binding site [nucleotide binding]
1284663004238	catalytic residue [active]
1284663004239	H2TH interface [polypeptide binding]; other site
1284663004240	putative catalytic residues [active]
1284663004241	turnover-facilitating residue; other site
1284663004242	intercalation triad [nucleotide binding]; other site
1284663004243	8OG recognition residue [nucleotide binding]; other site
1284663004244	putative reading head residues; other site
1284663004245	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1284663004246	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1284663004247	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1284663004248	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1284663004249	CoA-binding site [chemical binding]; other site
1284663004250	ATP-binding [chemical binding]; other site
1284663004251	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1284663004252	ATP cone domain; Region: ATP-cone; pfam03477
1284663004253	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1284663004254	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
1284663004255	primosomal protein DnaI; Reviewed; Region: PRK08939
1284663004256	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1284663004257	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663004258	Walker A motif; other site
1284663004259	ATP binding site [chemical binding]; other site
1284663004260	Walker B motif; other site
1284663004261	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1284663004262	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1284663004263	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1284663004264	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1284663004265	active site
1284663004266	dimer interface [polypeptide binding]; other site
1284663004267	motif 1; other site
1284663004268	motif 2; other site
1284663004269	motif 3; other site
1284663004270	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1284663004271	anticodon binding site; other site
1284663004272	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1284663004273	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1284663004274	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1284663004275	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1284663004276	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1284663004277	23S rRNA binding site [nucleotide binding]; other site
1284663004278	L21 binding site [polypeptide binding]; other site
1284663004279	L13 binding site [polypeptide binding]; other site
1284663004280	recombination factor protein RarA; Reviewed; Region: PRK13342
1284663004281	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663004282	Walker A motif; other site
1284663004283	ATP binding site [chemical binding]; other site
1284663004284	Walker B motif; other site
1284663004285	arginine finger; other site
1284663004286	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1284663004287	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1284663004288	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1284663004289	putative NAD(P) binding site [chemical binding]; other site
1284663004290	dimer interface [polypeptide binding]; other site
1284663004291	Predicted transcriptional regulators [Transcription]; Region: COG1733
1284663004292	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1284663004293	aspartate racemase; Region: asp_race; TIGR00035
1284663004294	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1284663004295	N-glycosyltransferase; Provisional; Region: PRK11204
1284663004296	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1284663004297	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
1284663004298	DXD motif; other site
1284663004299	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1284663004300	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663004301	active site
1284663004302	motif I; other site
1284663004303	motif II; other site
1284663004304	GTPase YqeH; Provisional; Region: PRK13796
1284663004305	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1284663004306	GTP/Mg2+ binding site [chemical binding]; other site
1284663004307	G4 box; other site
1284663004308	G5 box; other site
1284663004309	G1 box; other site
1284663004310	Switch I region; other site
1284663004311	G2 box; other site
1284663004312	G3 box; other site
1284663004313	Switch II region; other site
1284663004314	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
1284663004315	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1284663004316	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1284663004317	active site
1284663004318	(T/H)XGH motif; other site
1284663004319	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1284663004320	Zn2+ binding site [ion binding]; other site
1284663004321	Mg2+ binding site [ion binding]; other site
1284663004322	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1284663004323	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1284663004324	S-adenosylmethionine binding site [chemical binding]; other site
1284663004325	hypothetical protein; Provisional; Region: PRK13670
1284663004326	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
1284663004327	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1284663004328	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1284663004329	Predicted membrane protein [Function unknown]; Region: COG3212
1284663004330	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1284663004331	Cation efflux family; Region: Cation_efflux; pfam01545
1284663004332	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1284663004333	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1284663004334	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1284663004335	recombination factor protein RarA; Reviewed; Region: PRK13342
1284663004336	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663004337	Walker A motif; other site
1284663004338	ATP binding site [chemical binding]; other site
1284663004339	Walker B motif; other site
1284663004340	arginine finger; other site
1284663004341	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1284663004342	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1284663004343	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1284663004344	active site
1284663004345	phosphorylation site [posttranslational modification]
1284663004346	intermolecular recognition site; other site
1284663004347	dimerization interface [polypeptide binding]; other site
1284663004348	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1284663004349	DNA binding site [nucleotide binding]
1284663004350	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1284663004351	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1284663004352	dimerization interface [polypeptide binding]; other site
1284663004353	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1284663004354	dimer interface [polypeptide binding]; other site
1284663004355	phosphorylation site [posttranslational modification]
1284663004356	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1284663004357	ATP binding site [chemical binding]; other site
1284663004358	Mg2+ binding site [ion binding]; other site
1284663004359	G-X-G motif; other site
1284663004360	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
1284663004361	UbiA prenyltransferase family; Region: UbiA; pfam01040
1284663004362	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1284663004363	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1284663004364	Walker A/P-loop; other site
1284663004365	ATP binding site [chemical binding]; other site
1284663004366	Q-loop/lid; other site
1284663004367	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1284663004368	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1284663004369	ABC transporter signature motif; other site
1284663004370	Walker B; other site
1284663004371	D-loop; other site
1284663004372	H-loop/switch region; other site
1284663004373	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1284663004374	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1284663004375	active site
1284663004376	metal binding site [ion binding]; metal-binding site
1284663004377	DNA binding site [nucleotide binding]
1284663004378	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1284663004379	SdpI/YhfL protein family; Region: SdpI; pfam13630
1284663004380	OxaA-like protein precursor; Provisional; Region: PRK02463
1284663004381	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1284663004382	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
1284663004383	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1284663004384	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1284663004385	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1284663004386	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
1284663004387	Predicted transcriptional regulators [Transcription]; Region: COG1733
1284663004388	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1284663004389	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1284663004390	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1284663004391	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1284663004392	dimer interface [polypeptide binding]; other site
1284663004393	motif 1; other site
1284663004394	active site
1284663004395	motif 2; other site
1284663004396	motif 3; other site
1284663004397	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1284663004398	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1284663004399	putative tRNA-binding site [nucleotide binding]; other site
1284663004400	B3/4 domain; Region: B3_4; pfam03483
1284663004401	tRNA synthetase B5 domain; Region: B5; smart00874
1284663004402	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1284663004403	dimer interface [polypeptide binding]; other site
1284663004404	motif 1; other site
1284663004405	motif 3; other site
1284663004406	motif 2; other site
1284663004407	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1284663004408	YceG-like family; Region: YceG; pfam02618
1284663004409	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1284663004410	dimerization interface [polypeptide binding]; other site
1284663004411	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1284663004412	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1284663004413	Pyrimidine base specificity; other site
1284663004414	Sugar specificity; other site
1284663004415	ATP-binding site [chemical binding]; other site
1284663004416	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1284663004417	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1284663004418	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1284663004419	LytTr DNA-binding domain; Region: LytTR; pfam04397
1284663004420	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
1284663004421	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
1284663004422	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1284663004423	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1284663004424	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1284663004425	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1284663004426	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1284663004427	Rhomboid family; Region: Rhomboid; pfam01694
1284663004428	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
1284663004429	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1284663004430	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1284663004431	nucleotide binding site [chemical binding]; other site
1284663004432	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129
1284663004433	catalytic triad [active]
1284663004434	active site nucleophile [active]
1284663004435	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1284663004436	active site residue [active]
1284663004437	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
1284663004438	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1284663004439	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
1284663004440	active site
1284663004441	catalytic site [active]
1284663004442	metal binding site [ion binding]; metal-binding site
1284663004443	dimer interface [polypeptide binding]; other site
1284663004444	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1284663004445	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1284663004446	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1284663004447	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1284663004448	DNA binding residues [nucleotide binding]
1284663004449	putative dimer interface [polypeptide binding]; other site
1284663004450	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1284663004451	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1284663004452	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1284663004453	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
1284663004454	dUTPase; Region: dUTPase_2; pfam08761
1284663004455	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
1284663004456	active site
1284663004457	homodimer interface [polypeptide binding]; other site
1284663004458	metal binding site [ion binding]; metal-binding site
1284663004459	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663004460	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1284663004461	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1284663004462	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1284663004463	Protein of unknown function (DUF464); Region: DUF464; pfam04327
1284663004464	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1284663004465	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1284663004466	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1284663004467	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1284663004468	active site
1284663004469	elongation factor P; Validated; Region: PRK00529
1284663004470	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1284663004471	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1284663004472	RNA binding site [nucleotide binding]; other site
1284663004473	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1284663004474	RNA binding site [nucleotide binding]; other site
1284663004475	Asp23 family; Region: Asp23; pfam03780
1284663004476	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1284663004477	putative RNA binding site [nucleotide binding]; other site
1284663004478	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
1284663004479	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1284663004480	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1284663004481	homodimer interface [polypeptide binding]; other site
1284663004482	NADP binding site [chemical binding]; other site
1284663004483	substrate binding site [chemical binding]; other site
1284663004484	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1284663004485	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1284663004486	generic binding surface II; other site
1284663004487	generic binding surface I; other site
1284663004488	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1284663004489	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1284663004490	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1284663004491	substrate binding pocket [chemical binding]; other site
1284663004492	chain length determination region; other site
1284663004493	substrate-Mg2+ binding site; other site
1284663004494	catalytic residues [active]
1284663004495	aspartate-rich region 1; other site
1284663004496	active site lid residues [active]
1284663004497	aspartate-rich region 2; other site
1284663004498	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1284663004499	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1284663004500	RNA binding surface [nucleotide binding]; other site
1284663004501	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1284663004502	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1284663004503	arginine repressor; Provisional; Region: PRK04280
1284663004504	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1284663004505	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1284663004506	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1284663004507	Walker A/P-loop; other site
1284663004508	ATP binding site [chemical binding]; other site
1284663004509	Q-loop/lid; other site
1284663004510	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1284663004511	ABC transporter signature motif; other site
1284663004512	Walker B; other site
1284663004513	D-loop; other site
1284663004514	H-loop/switch region; other site
1284663004515	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1284663004516	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
1284663004517	Walker A/P-loop; other site
1284663004518	ATP binding site [chemical binding]; other site
1284663004519	Q-loop/lid; other site
1284663004520	ABC transporter signature motif; other site
1284663004521	Walker B; other site
1284663004522	D-loop; other site
1284663004523	H-loop/switch region; other site
1284663004524	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1284663004525	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663004526	dimer interface [polypeptide binding]; other site
1284663004527	conserved gate region; other site
1284663004528	putative PBP binding loops; other site
1284663004529	ABC-ATPase subunit interface; other site
1284663004530	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1284663004531	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1284663004532	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663004533	dimer interface [polypeptide binding]; other site
1284663004534	conserved gate region; other site
1284663004535	putative PBP binding loops; other site
1284663004536	ABC-ATPase subunit interface; other site
1284663004537	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1284663004538	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1284663004539	catalytic site [active]
1284663004540	G-X2-G-X-G-K; other site
1284663004541	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1284663004542	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1284663004543	Flavoprotein; Region: Flavoprotein; pfam02441
1284663004544	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1284663004545	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1284663004546	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1284663004547	ATP binding site [chemical binding]; other site
1284663004548	putative Mg++ binding site [ion binding]; other site
1284663004549	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1284663004550	nucleotide binding region [chemical binding]; other site
1284663004551	ATP-binding site [chemical binding]; other site
1284663004552	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1284663004553	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1284663004554	putative active site [active]
1284663004555	substrate binding site [chemical binding]; other site
1284663004556	putative cosubstrate binding site; other site
1284663004557	catalytic site [active]
1284663004558	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1284663004559	substrate binding site [chemical binding]; other site
1284663004560	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1284663004561	NusB family; Region: NusB; pfam01029
1284663004562	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1284663004563	S-adenosylmethionine binding site [chemical binding]; other site
1284663004564	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1284663004565	active site
1284663004566	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1284663004567	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1284663004568	active site
1284663004569	ATP binding site [chemical binding]; other site
1284663004570	substrate binding site [chemical binding]; other site
1284663004571	activation loop (A-loop); other site
1284663004572	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1284663004573	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1284663004574	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1284663004575	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1284663004576	GTPase RsgA; Reviewed; Region: PRK00098
1284663004577	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1284663004578	RNA binding site [nucleotide binding]; other site
1284663004579	homodimer interface [polypeptide binding]; other site
1284663004580	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1284663004581	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1284663004582	GTP/Mg2+ binding site [chemical binding]; other site
1284663004583	G4 box; other site
1284663004584	G5 box; other site
1284663004585	G1 box; other site
1284663004586	Switch I region; other site
1284663004587	G2 box; other site
1284663004588	G3 box; other site
1284663004589	Switch II region; other site
1284663004590	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1284663004591	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1284663004592	substrate binding site [chemical binding]; other site
1284663004593	hexamer interface [polypeptide binding]; other site
1284663004594	metal binding site [ion binding]; metal-binding site
1284663004595	Thiamine pyrophosphokinase; Region: TPK; cd07995
1284663004596	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
1284663004597	active site
1284663004598	dimerization interface [polypeptide binding]; other site
1284663004599	thiamine binding site [chemical binding]; other site
1284663004600	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1284663004601	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1284663004602	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
1284663004603	DAK2 domain; Region: Dak2; pfam02734
1284663004604	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1284663004605	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1284663004606	generic binding surface II; other site
1284663004607	ssDNA binding site; other site
1284663004608	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1284663004609	ATP binding site [chemical binding]; other site
1284663004610	putative Mg++ binding site [ion binding]; other site
1284663004611	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1284663004612	nucleotide binding region [chemical binding]; other site
1284663004613	ATP-binding site [chemical binding]; other site
1284663004614	putative phosphate acyltransferase; Provisional; Region: PRK05331
1284663004615	acyl carrier protein; Provisional; Region: acpP; PRK00982
1284663004616	ribonuclease III; Reviewed; Region: rnc; PRK00102
1284663004617	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1284663004618	dimerization interface [polypeptide binding]; other site
1284663004619	active site
1284663004620	metal binding site [ion binding]; metal-binding site
1284663004621	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1284663004622	dsRNA binding site [nucleotide binding]; other site
1284663004623	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1284663004624	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1284663004625	Walker A/P-loop; other site
1284663004626	ATP binding site [chemical binding]; other site
1284663004627	Q-loop/lid; other site
1284663004628	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1284663004629	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1284663004630	ABC transporter signature motif; other site
1284663004631	Walker B; other site
1284663004632	D-loop; other site
1284663004633	H-loop/switch region; other site
1284663004634	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1284663004635	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1284663004636	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1284663004637	P loop; other site
1284663004638	GTP binding site [chemical binding]; other site
1284663004639	putative DNA-binding protein; Validated; Region: PRK00118
1284663004640	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
1284663004641	signal recognition particle protein; Provisional; Region: PRK10867
1284663004642	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1284663004643	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1284663004644	P loop; other site
1284663004645	GTP binding site [chemical binding]; other site
1284663004646	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1284663004647	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1284663004648	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1284663004649	KH domain; Region: KH_4; pfam13083
1284663004650	G-X-X-G motif; other site
1284663004651	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1284663004652	RimM N-terminal domain; Region: RimM; pfam01782
1284663004653	PRC-barrel domain; Region: PRC; pfam05239
1284663004654	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1284663004655	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1284663004656	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1284663004657	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1284663004658	MucBP domain; Region: MucBP; pfam06458
1284663004659	MucBP domain; Region: MucBP; pfam06458
1284663004660	MucBP domain; Region: MucBP; pfam06458
1284663004661	MucBP domain; Region: MucBP; pfam06458
1284663004662	MucBP domain; Region: MucBP; pfam06458
1284663004663	DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033
1284663004664	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663004665	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663004666	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1284663004667	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1284663004668	putative NAD(P) binding site [chemical binding]; other site
1284663004669	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1284663004670	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1284663004671	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1284663004672	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1284663004673	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1284663004674	MFS/sugar transport protein; Region: MFS_2; pfam13347
1284663004675	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663004676	putative substrate translocation pore; other site
1284663004677	N-acetylmannosamine kinase; Provisional; Region: PRK05082
1284663004678	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1284663004679	nucleotide binding site [chemical binding]; other site
1284663004680	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663004681	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663004682	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1284663004683	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1284663004684	Walker A/P-loop; other site
1284663004685	ATP binding site [chemical binding]; other site
1284663004686	Q-loop/lid; other site
1284663004687	ABC transporter signature motif; other site
1284663004688	Walker B; other site
1284663004689	D-loop; other site
1284663004690	H-loop/switch region; other site
1284663004691	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1284663004692	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1284663004693	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1284663004694	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1284663004695	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1284663004696	glutamine binding [chemical binding]; other site
1284663004697	catalytic triad [active]
1284663004698	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1284663004699	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1284663004700	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1284663004701	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1284663004702	active site
1284663004703	ribulose/triose binding site [chemical binding]; other site
1284663004704	phosphate binding site [ion binding]; other site
1284663004705	substrate (anthranilate) binding pocket [chemical binding]; other site
1284663004706	product (indole) binding pocket [chemical binding]; other site
1284663004707	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1284663004708	active site
1284663004709	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1284663004710	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1284663004711	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663004712	catalytic residue [active]
1284663004713	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1284663004714	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1284663004715	substrate binding site [chemical binding]; other site
1284663004716	active site
1284663004717	catalytic residues [active]
1284663004718	heterodimer interface [polypeptide binding]; other site
1284663004719	potential frameshift: common BLAST hit: Isochorismatase
1284663004720	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1284663004721	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1284663004722	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1284663004723	NADP binding site [chemical binding]; other site
1284663004724	dimer interface [polypeptide binding]; other site
1284663004725	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1284663004726	potential frameshift: common BLAST hit: Hypothetical membrane protein
1284663004727	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1284663004728	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1284663004729	metal binding site [ion binding]; metal-binding site
1284663004730	potential frameshift: common BLAST hit: adh1
1284663004731	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1284663004732	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1284663004733	NAD(P) binding site [chemical binding]; other site
1284663004734	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1284663004735	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1284663004736	short chain dehydrogenase; Validated; Region: PRK06182
1284663004737	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1284663004738	NADP binding site [chemical binding]; other site
1284663004739	active site
1284663004740	steroid binding site; other site
1284663004741	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1284663004742	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1284663004743	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1284663004744	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1284663004745	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1284663004746	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1284663004747	dimer interface [polypeptide binding]; other site
1284663004748	active site
1284663004749	CoA binding pocket [chemical binding]; other site
1284663004750	acyl carrier protein; Provisional; Region: acpP; PRK00982
1284663004751	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1284663004752	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1284663004753	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663004754	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1284663004755	NAD(P) binding site [chemical binding]; other site
1284663004756	active site
1284663004757	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1284663004758	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1284663004759	dimer interface [polypeptide binding]; other site
1284663004760	active site
1284663004761	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1284663004762	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1284663004763	carboxyltransferase (CT) interaction site; other site
1284663004764	biotinylation site [posttranslational modification]; other site
1284663004765	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1284663004766	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1284663004767	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1284663004768	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1284663004769	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1284663004770	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1284663004771	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1284663004772	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825
1284663004773	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079
1284663004774	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1284663004775	NAD binding site [chemical binding]; other site
1284663004776	homotetramer interface [polypeptide binding]; other site
1284663004777	homodimer interface [polypeptide binding]; other site
1284663004778	substrate binding site [chemical binding]; other site
1284663004779	active site
1284663004780	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1284663004781	Protein of unknown function (DUF554); Region: DUF554; pfam04474
1284663004782	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663004783	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663004784	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1284663004785	dimerization interface [polypeptide binding]; other site
1284663004786	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1284663004787	GTPase RsgA; Reviewed; Region: PRK01889
1284663004788	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1284663004789	RNA binding site [nucleotide binding]; other site
1284663004790	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1284663004791	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1284663004792	GTP/Mg2+ binding site [chemical binding]; other site
1284663004793	G4 box; other site
1284663004794	G5 box; other site
1284663004795	G1 box; other site
1284663004796	Switch I region; other site
1284663004797	G2 box; other site
1284663004798	G3 box; other site
1284663004799	Switch II region; other site
1284663004800	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663004801	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663004802	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663004803	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663004804	putative substrate translocation pore; other site
1284663004805	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663004806	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
1284663004807	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1284663004808	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1284663004809	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1284663004810	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1284663004811	S-adenosylmethionine binding site [chemical binding]; other site
1284663004812	potential frameshift: common BLAST hit: Integrase
1284663004813	putative transposase OrfB; Reviewed; Region: PHA02517
1284663004814	Integrase core domain; Region: rve_3; cl15866
1284663004815	Chitin binding domain; Region: Chitin_bind_3; pfam03067
1284663004816	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1284663004817	TspO/MBR family; Region: TspO_MBR; pfam03073
1284663004818	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1284663004819	Ligand Binding Site [chemical binding]; other site
1284663004820	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1284663004821	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1284663004822	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1284663004823	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1284663004824	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1284663004825	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1284663004826	CsbD-like; Region: CsbD; cl17424
1284663004827	Peptidase family C69; Region: Peptidase_C69; pfam03577
1284663004828	4-oxalocrotonate tautomerase; Provisional; Region: PRK02220
1284663004829	active site 1 [active]
1284663004830	dimer interface [polypeptide binding]; other site
1284663004831	hexamer interface [polypeptide binding]; other site
1284663004832	active site 2 [active]
1284663004833	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1284663004834	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1284663004835	active site
1284663004836	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1284663004837	substrate binding site [chemical binding]; other site
1284663004838	catalytic residues [active]
1284663004839	dimer interface [polypeptide binding]; other site
1284663004840	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1284663004841	UbiA prenyltransferase family; Region: UbiA; pfam01040
1284663004842	Ion channel; Region: Ion_trans_2; pfam07885
1284663004843	4-aminobutyrate aminotransferase; Provisional; Region: PRK08593
1284663004844	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1284663004845	inhibitor-cofactor binding pocket; inhibition site
1284663004846	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663004847	catalytic residue [active]
1284663004848	amino acid transporter; Region: 2A0306; TIGR00909
1284663004849	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1284663004850	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1284663004851	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663004852	active site
1284663004853	motif I; other site
1284663004854	motif II; other site
1284663004855	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1284663004856	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
1284663004857	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1284663004858	S-adenosylmethionine binding site [chemical binding]; other site
1284663004859	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
1284663004860	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1284663004861	Double zinc ribbon; Region: DZR; pfam12773
1284663004862	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663004863	putative substrate translocation pore; other site
1284663004864	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663004865	maltose phosphorylase; Provisional; Region: PRK13807
1284663004866	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1284663004867	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1284663004868	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
1284663004869	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1284663004870	active site
1284663004871	catalytic residues [active]
1284663004872	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1284663004873	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1284663004874	homotetramer interface [polypeptide binding]; other site
1284663004875	FMN binding site [chemical binding]; other site
1284663004876	homodimer contacts [polypeptide binding]; other site
1284663004877	putative active site [active]
1284663004878	putative substrate binding site [chemical binding]; other site
1284663004879	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
1284663004880	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1284663004881	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
1284663004882	diphosphomevalonate decarboxylase; Region: PLN02407
1284663004883	mevalonate kinase; Region: mevalon_kin; TIGR00549
1284663004884	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1284663004885	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1284663004886	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
1284663004887	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1284663004888	active site
1284663004889	catalytic site [active]
1284663004890	substrate binding site [chemical binding]; other site
1284663004891	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1284663004892	ATP binding site [chemical binding]; other site
1284663004893	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1284663004894	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
1284663004895	aspartate aminotransferase; Provisional; Region: PRK05764
1284663004896	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1284663004897	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663004898	homodimer interface [polypeptide binding]; other site
1284663004899	catalytic residue [active]
1284663004900	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1284663004901	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1284663004902	Dimer interface [polypeptide binding]; other site
1284663004903	anticodon binding site; other site
1284663004904	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1284663004905	homodimer interface [polypeptide binding]; other site
1284663004906	motif 1; other site
1284663004907	motif 2; other site
1284663004908	active site
1284663004909	motif 3; other site
1284663004910	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1284663004911	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1284663004912	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1284663004913	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1284663004914	Walker A/P-loop; other site
1284663004915	ATP binding site [chemical binding]; other site
1284663004916	Q-loop/lid; other site
1284663004917	ABC transporter signature motif; other site
1284663004918	Walker B; other site
1284663004919	D-loop; other site
1284663004920	H-loop/switch region; other site
1284663004921	NIL domain; Region: NIL; pfam09383
1284663004922	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663004923	dimer interface [polypeptide binding]; other site
1284663004924	conserved gate region; other site
1284663004925	ABC-ATPase subunit interface; other site
1284663004926	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1284663004927	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1284663004928	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1284663004929	Ligand Binding Site [chemical binding]; other site
1284663004930	potential frameshift: common BLAST hit: Iron ABC transporter, permease protein
1284663004931	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663004932	dimer interface [polypeptide binding]; other site
1284663004933	conserved gate region; other site
1284663004934	putative PBP binding loops; other site
1284663004935	ABC-ATPase subunit interface; other site
1284663004936	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1284663004937	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663004938	dimer interface [polypeptide binding]; other site
1284663004939	conserved gate region; other site
1284663004940	putative PBP binding loops; other site
1284663004941	ABC-ATPase subunit interface; other site
1284663004942	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
1284663004943	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1284663004944	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1284663004945	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1284663004946	Walker A/P-loop; other site
1284663004947	ATP binding site [chemical binding]; other site
1284663004948	Q-loop/lid; other site
1284663004949	ABC transporter signature motif; other site
1284663004950	Walker B; other site
1284663004951	D-loop; other site
1284663004952	H-loop/switch region; other site
1284663004953	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1284663004954	Transglycosylase; Region: Transgly; pfam00912
1284663004955	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1284663004956	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
1284663004957	hypothetical protein; Provisional; Region: PRK13660
1284663004958	cell division protein GpsB; Provisional; Region: PRK14127
1284663004959	DivIVA domain; Region: DivI1A_domain; TIGR03544
1284663004960	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1284663004961	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1284663004962	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1284663004963	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1284663004964	dimerization interface [polypeptide binding]; other site
1284663004965	putative DNA binding site [nucleotide binding]; other site
1284663004966	putative Zn2+ binding site [ion binding]; other site
1284663004967	potential frameshift: common BLAST hit: Drug resistance transport protein, major facilitator subfamily (MFS), EmrB/QacA subfamily
1284663004968	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663004969	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1284663004970	putative substrate translocation pore; other site
1284663004971	esterase; Provisional; Region: PRK10566
1284663004972	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1284663004973	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1284663004974	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1284663004975	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1284663004976	active site
1284663004977	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
1284663004978	putative dimer interface [polypeptide binding]; other site
1284663004979	catalytic triad [active]
1284663004980	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663004981	Coenzyme A binding pocket [chemical binding]; other site
1284663004982	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
1284663004983	active site
1284663004984	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
1284663004985	putative dimer interface [polypeptide binding]; other site
1284663004986	catalytic triad [active]
1284663004987	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1284663004988	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
1284663004989	Walker A/P-loop; other site
1284663004990	ATP binding site [chemical binding]; other site
1284663004991	Q-loop/lid; other site
1284663004992	ABC transporter signature motif; other site
1284663004993	Walker B; other site
1284663004994	D-loop; other site
1284663004995	H-loop/switch region; other site
1284663004996	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1284663004997	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1284663004998	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1284663004999	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1284663005000	RNA/DNA hybrid binding site [nucleotide binding]; other site
1284663005001	active site
1284663005002	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1284663005003	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1284663005004	Potassium binding sites [ion binding]; other site
1284663005005	Cesium cation binding sites [ion binding]; other site
1284663005006	lipoprotein signal peptidase; Provisional; Region: PRK14797
1284663005007	lipoprotein signal peptidase; Provisional; Region: PRK14787
1284663005008	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1284663005009	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1284663005010	RNA binding surface [nucleotide binding]; other site
1284663005011	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1284663005012	active site
1284663005013	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1284663005014	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1284663005015	active site
1284663005016	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838
1284663005017	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1284663005018	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1284663005019	catalytic site [active]
1284663005020	subunit interface [polypeptide binding]; other site
1284663005021	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1284663005022	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
1284663005023	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1284663005024	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1284663005025	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
1284663005026	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1284663005027	catalytic core [active]
1284663005028	Domain of unknown function (DU1801); Region: DUF1801; cl17490
1284663005029	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1284663005030	Helix-turn-helix domain; Region: HTH_38; pfam13936
1284663005031	Integrase core domain; Region: rve; pfam00665
1284663005032	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
1284663005033	Chloramphenicol acetyltransferase; Region: CAT; smart01059
1284663005034	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
1284663005035	GIY-YIG motif/motif A; other site
1284663005036	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
1284663005037	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
1284663005038	nudix motif; other site
1284663005039	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1284663005040	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663005041	Walker A/P-loop; other site
1284663005042	ATP binding site [chemical binding]; other site
1284663005043	Q-loop/lid; other site
1284663005044	ABC transporter signature motif; other site
1284663005045	Walker B; other site
1284663005046	D-loop; other site
1284663005047	H-loop/switch region; other site
1284663005048	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1284663005049	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
1284663005050	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1284663005051	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1284663005052	MarR family; Region: MarR_2; pfam12802
1284663005053	EDD domain protein, DegV family; Region: DegV; TIGR00762
1284663005054	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1284663005055	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663005056	Coenzyme A binding pocket [chemical binding]; other site
1284663005057	Protein of unknown function (DUF975); Region: DUF975; cl10504
1284663005058	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
1284663005059	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1284663005060	nucleotide binding site/active site [active]
1284663005061	HIT family signature motif; other site
1284663005062	catalytic residue [active]
1284663005063	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663005064	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663005065	putative substrate translocation pore; other site
1284663005066	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
1284663005067	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
1284663005068	Predicted membrane protein [Function unknown]; Region: COG2035
1284663005069	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1284663005070	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1284663005071	L-lactate permease; Region: Lactate_perm; cl00701
1284663005072	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1284663005073	substrate binding site; other site
1284663005074	dimer interface; other site
1284663005075	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
1284663005076	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1284663005077	putative NAD(P) binding site [chemical binding]; other site
1284663005078	putative catalytic Zn binding site [ion binding]; other site
1284663005079	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1284663005080	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1284663005081	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1284663005082	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1284663005083	potential frameshift: common BLAST hit: Acetyltransferase, GNAT family
1284663005084	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1284663005085	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1284663005086	MarR family; Region: MarR; pfam01047
1284663005087	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1284663005088	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1284663005089	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1284663005090	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1284663005091	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1284663005092	active site
1284663005093	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1284663005094	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
1284663005095	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
1284663005096	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1284663005097	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1284663005098	SelR domain; Region: SelR; pfam01641
1284663005099	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1284663005100	DHH family; Region: DHH; pfam01368
1284663005101	DHHA2 domain; Region: DHHA2; pfam02833
1284663005102	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663005103	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663005104	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1284663005105	dimerization interface [polypeptide binding]; other site
1284663005106	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1284663005107	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1284663005108	CAP-like domain; other site
1284663005109	active site
1284663005110	primary dimer interface [polypeptide binding]; other site
1284663005111	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1284663005112	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1284663005113	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1284663005114	ATP binding site [chemical binding]; other site
1284663005115	Mg2+ binding site [ion binding]; other site
1284663005116	G-X-G motif; other site
1284663005117	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1284663005118	anchoring element; other site
1284663005119	dimer interface [polypeptide binding]; other site
1284663005120	ATP binding site [chemical binding]; other site
1284663005121	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1284663005122	active site
1284663005123	putative metal-binding site [ion binding]; other site
1284663005124	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1284663005125	membrane protein; Provisional; Region: PRK14392
1284663005126	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
1284663005127	active site
1284663005128	catalytic residues [active]
1284663005129	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1284663005130	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663005131	Walker A motif; other site
1284663005132	ATP binding site [chemical binding]; other site
1284663005133	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663005134	Walker B motif; other site
1284663005135	arginine finger; other site
1284663005136	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1284663005137	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1284663005138	active site
1284663005139	HslU subunit interaction site [polypeptide binding]; other site
1284663005140	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1284663005141	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1284663005142	active site
1284663005143	DNA binding site [nucleotide binding]
1284663005144	Int/Topo IB signature motif; other site
1284663005145	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1284663005146	Glucose inhibited division protein A; Region: GIDA; pfam01134
1284663005147	DNA topoisomerase I; Validated; Region: PRK05582
1284663005148	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1284663005149	active site
1284663005150	interdomain interaction site; other site
1284663005151	putative metal-binding site [ion binding]; other site
1284663005152	nucleotide binding site [chemical binding]; other site
1284663005153	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1284663005154	domain I; other site
1284663005155	DNA binding groove [nucleotide binding]
1284663005156	phosphate binding site [ion binding]; other site
1284663005157	domain II; other site
1284663005158	domain III; other site
1284663005159	nucleotide binding site [chemical binding]; other site
1284663005160	catalytic site [active]
1284663005161	domain IV; other site
1284663005162	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1284663005163	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1284663005164	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1284663005165	DNA protecting protein DprA; Region: dprA; TIGR00732
1284663005166	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1284663005167	RNA/DNA hybrid binding site [nucleotide binding]; other site
1284663005168	active site
1284663005169	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
1284663005170	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1284663005171	GTP/Mg2+ binding site [chemical binding]; other site
1284663005172	G4 box; other site
1284663005173	G5 box; other site
1284663005174	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1284663005175	G1 box; other site
1284663005176	G1 box; other site
1284663005177	GTP/Mg2+ binding site [chemical binding]; other site
1284663005178	Switch I region; other site
1284663005179	G2 box; other site
1284663005180	G2 box; other site
1284663005181	G3 box; other site
1284663005182	G3 box; other site
1284663005183	Switch II region; other site
1284663005184	Switch II region; other site
1284663005185	G4 box; other site
1284663005186	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1284663005187	substrate binding site [chemical binding]; other site
1284663005188	THF binding site; other site
1284663005189	zinc-binding site [ion binding]; other site
1284663005190	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663005191	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663005192	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1284663005193	dimerization interface [polypeptide binding]; other site
1284663005194	Mrr N-terminal domain; Region: Mrr_N; pfam14338
1284663005195	Restriction endonuclease; Region: Mrr_cat; pfam04471
1284663005196	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1284663005197	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1284663005198	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1284663005199	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1284663005200	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663005201	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663005202	putative substrate translocation pore; other site
1284663005203	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1284663005204	C-terminal peptidase (prc); Region: prc; TIGR00225
1284663005205	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1284663005206	protein binding site [polypeptide binding]; other site
1284663005207	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1284663005208	Catalytic dyad [active]
1284663005209	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1284663005210	hypothetical protein; Provisional; Region: PRK13672
1284663005211	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911
1284663005212	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
1284663005213	active site
1284663005214	catalytic triad [active]
1284663005215	oxyanion hole [active]
1284663005216	EDD domain protein, DegV family; Region: DegV; TIGR00762
1284663005217	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1284663005218	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1284663005219	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1284663005220	folate binding site [chemical binding]; other site
1284663005221	NADP+ binding site [chemical binding]; other site
1284663005222	thymidylate synthase; Region: thym_sym; TIGR03284
1284663005223	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1284663005224	dimerization interface [polypeptide binding]; other site
1284663005225	active site
1284663005226	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1284663005227	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663005228	Walker A/P-loop; other site
1284663005229	ATP binding site [chemical binding]; other site
1284663005230	Q-loop/lid; other site
1284663005231	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1284663005232	ABC transporter signature motif; other site
1284663005233	Walker B; other site
1284663005234	D-loop; other site
1284663005235	ABC transporter; Region: ABC_tran_2; pfam12848
1284663005236	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1284663005237	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1284663005238	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1284663005239	active site
1284663005240	NTP binding site [chemical binding]; other site
1284663005241	metal binding triad [ion binding]; metal-binding site
1284663005242	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1284663005243	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1284663005244	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1284663005245	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1284663005246	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1284663005247	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1284663005248	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1284663005249	active site
1284663005250	motif I; other site
1284663005251	motif II; other site
1284663005252	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663005253	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1284663005254	binding surface
1284663005255	TPR motif; other site
1284663005256	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
1284663005257	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1284663005258	binding surface
1284663005259	TPR motif; other site
1284663005260	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1284663005261	TPR motif; other site
1284663005262	binding surface
1284663005263	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1284663005264	IHF dimer interface [polypeptide binding]; other site
1284663005265	IHF - DNA interface [nucleotide binding]; other site
1284663005266	GTP-binding protein Der; Reviewed; Region: PRK00093
1284663005267	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1284663005268	G1 box; other site
1284663005269	GTP/Mg2+ binding site [chemical binding]; other site
1284663005270	Switch I region; other site
1284663005271	G2 box; other site
1284663005272	Switch II region; other site
1284663005273	G3 box; other site
1284663005274	G4 box; other site
1284663005275	G5 box; other site
1284663005276	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1284663005277	G1 box; other site
1284663005278	GTP/Mg2+ binding site [chemical binding]; other site
1284663005279	Switch I region; other site
1284663005280	G2 box; other site
1284663005281	G3 box; other site
1284663005282	Switch II region; other site
1284663005283	G4 box; other site
1284663005284	G5 box; other site
1284663005285	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1284663005286	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1284663005287	RNA binding site [nucleotide binding]; other site
1284663005288	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1284663005289	RNA binding site [nucleotide binding]; other site
1284663005290	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1284663005291	RNA binding site [nucleotide binding]; other site
1284663005292	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1284663005293	RNA binding site [nucleotide binding]; other site
1284663005294	cytidylate kinase; Provisional; Region: cmk; PRK00023
1284663005295	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1284663005296	CMP-binding site; other site
1284663005297	The sites determining sugar specificity; other site
1284663005298	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1284663005299	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1284663005300	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1284663005301	ATP binding site [chemical binding]; other site
1284663005302	putative Mg++ binding site [ion binding]; other site
1284663005303	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1284663005304	nucleotide binding region [chemical binding]; other site
1284663005305	ATP-binding site [chemical binding]; other site
1284663005306	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
1284663005307	Predicted membrane protein [Function unknown]; Region: COG3601
1284663005308	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1284663005309	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1284663005310	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1284663005311	RNA binding surface [nucleotide binding]; other site
1284663005312	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1284663005313	active site
1284663005314	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
1284663005315	ScpA/B protein; Region: ScpA_ScpB; cl00598
1284663005316	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1284663005317	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1284663005318	active site
1284663005319	Int/Topo IB signature motif; other site
1284663005320	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1284663005321	S1 domain; Region: S1_2; pfam13509
1284663005322	Protein of unknown function (DUF441); Region: DUF441; pfam04284
1284663005323	pyruvate kinase; Provisional; Region: PRK06354
1284663005324	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1284663005325	domain interfaces; other site
1284663005326	active site
1284663005327	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1284663005328	6-phosphofructokinase; Provisional; Region: PRK03202
1284663005329	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1284663005330	active site
1284663005331	ADP/pyrophosphate binding site [chemical binding]; other site
1284663005332	dimerization interface [polypeptide binding]; other site
1284663005333	allosteric effector site; other site
1284663005334	fructose-1,6-bisphosphate binding site; other site
1284663005335	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
1284663005336	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
1284663005337	active site
1284663005338	PHP Thumb interface [polypeptide binding]; other site
1284663005339	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1284663005340	generic binding surface I; other site
1284663005341	generic binding surface II; other site
1284663005342	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
1284663005343	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1284663005344	Clp amino terminal domain; Region: Clp_N; pfam02861
1284663005345	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663005346	Walker A motif; other site
1284663005347	ATP binding site [chemical binding]; other site
1284663005348	Walker B motif; other site
1284663005349	arginine finger; other site
1284663005350	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663005351	Walker A motif; other site
1284663005352	ATP binding site [chemical binding]; other site
1284663005353	Walker B motif; other site
1284663005354	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1284663005355	peptidase T; Region: peptidase-T; TIGR01882
1284663005356	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1284663005357	metal binding site [ion binding]; metal-binding site
1284663005358	dimer interface [polypeptide binding]; other site
1284663005359	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1284663005360	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1284663005361	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1284663005362	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1284663005363	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1284663005364	Family of unknown function (DUF633); Region: DUF633; pfam04816
1284663005365	O-Antigen ligase; Region: Wzy_C; pfam04932
1284663005366	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1284663005367	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1284663005368	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663005369	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1284663005370	Walker A/P-loop; other site
1284663005371	ATP binding site [chemical binding]; other site
1284663005372	Q-loop/lid; other site
1284663005373	ABC transporter signature motif; other site
1284663005374	Walker B; other site
1284663005375	D-loop; other site
1284663005376	H-loop/switch region; other site
1284663005377	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1284663005378	MarR family; Region: MarR_2; pfam12802
1284663005379	phosphoenolpyruvate synthase; Validated; Region: PRK06464
1284663005380	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1284663005381	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1284663005382	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1284663005383	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1284663005384	active site residue [active]
1284663005385	MarR family; Region: MarR_2; cl17246
1284663005386	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1284663005387	Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243
1284663005388	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1284663005389	putative NAD(P) binding site [chemical binding]; other site
1284663005390	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
1284663005391	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
1284663005392	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1284663005393	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1284663005394	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1284663005395	enolase; Provisional; Region: eno; PRK00077
1284663005396	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1284663005397	dimer interface [polypeptide binding]; other site
1284663005398	metal binding site [ion binding]; metal-binding site
1284663005399	substrate binding pocket [chemical binding]; other site
1284663005400	potential frameshift: common BLAST hit: Drug resistance transport protein, major facilitator subfamily (MFS), EmrB/QacA subfamily
1284663005401	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663005402	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663005403	putative substrate translocation pore; other site
1284663005404	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1284663005405	MarR family; Region: MarR_2; pfam12802
1284663005406	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
1284663005407	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
1284663005408	metal binding site [ion binding]; metal-binding site
1284663005409	dimer interface [polypeptide binding]; other site
1284663005410	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
1284663005411	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1284663005412	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1284663005413	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1284663005414	active site residue [active]
1284663005415	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1284663005416	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1284663005417	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1284663005418	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
1284663005419	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
1284663005420	nudix motif; other site
1284663005421	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1284663005422	ArsC family; Region: ArsC; pfam03960
1284663005423	putative catalytic residues [active]
1284663005424	thiol/disulfide switch; other site
1284663005425	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
1284663005426	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663005427	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1284663005428	NAD(P) binding site [chemical binding]; other site
1284663005429	active site
1284663005430	Uncharacterized conserved protein [Function unknown]; Region: COG4715
1284663005431	tetratricopeptide repeat protein; Provisional; Region: PRK11788
1284663005432	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663005433	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1284663005434	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663005435	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1284663005436	DNA-binding interface [nucleotide binding]; DNA binding site
1284663005437	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1284663005438	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1284663005439	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1284663005440	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1284663005441	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1284663005442	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1284663005443	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663005444	motif II; other site
1284663005445	maltose O-acetyltransferase; Provisional; Region: PRK10092
1284663005446	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1284663005447	active site
1284663005448	substrate binding site [chemical binding]; other site
1284663005449	trimer interface [polypeptide binding]; other site
1284663005450	CoA binding site [chemical binding]; other site
1284663005451	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1284663005452	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1284663005453	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1284663005454	putative active site [active]
1284663005455	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1284663005456	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663005457	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1284663005458	NAD(P) binding site [chemical binding]; other site
1284663005459	active site
1284663005460	Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012
1284663005461	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663005462	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1284663005463	putative Zn2+ binding site [ion binding]; other site
1284663005464	putative DNA binding site [nucleotide binding]; other site
1284663005465	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1284663005466	dimerization interface [polypeptide binding]; other site
1284663005467	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1284663005468	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1284663005469	putative NAD(P) binding site [chemical binding]; other site
1284663005470	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
1284663005471	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1284663005472	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1284663005473	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1284663005474	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1284663005475	active site
1284663005476	phosphorylation site [posttranslational modification]
1284663005477	intermolecular recognition site; other site
1284663005478	dimerization interface [polypeptide binding]; other site
1284663005479	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1284663005480	DNA binding residues [nucleotide binding]
1284663005481	dimerization interface [polypeptide binding]; other site
1284663005482	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1284663005483	Histidine kinase; Region: HisKA_3; pfam07730
1284663005484	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1284663005485	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1284663005486	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1284663005487	Walker A/P-loop; other site
1284663005488	ATP binding site [chemical binding]; other site
1284663005489	Q-loop/lid; other site
1284663005490	ABC transporter signature motif; other site
1284663005491	Walker B; other site
1284663005492	D-loop; other site
1284663005493	H-loop/switch region; other site
1284663005494	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1284663005495	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663005496	Coenzyme A binding pocket [chemical binding]; other site
1284663005497	MarR family; Region: MarR; pfam01047
1284663005498	Predicted membrane protein [Function unknown]; Region: COG2364
1284663005499	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
1284663005500	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663005501	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1284663005502	Walker A/P-loop; other site
1284663005503	ATP binding site [chemical binding]; other site
1284663005504	Q-loop/lid; other site
1284663005505	ABC transporter signature motif; other site
1284663005506	Walker B; other site
1284663005507	D-loop; other site
1284663005508	H-loop/switch region; other site
1284663005509	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1284663005510	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1284663005511	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1284663005512	Walker A/P-loop; other site
1284663005513	ATP binding site [chemical binding]; other site
1284663005514	Q-loop/lid; other site
1284663005515	ABC transporter signature motif; other site
1284663005516	Walker B; other site
1284663005517	D-loop; other site
1284663005518	H-loop/switch region; other site
1284663005519	Predicted transcriptional regulators [Transcription]; Region: COG1725
1284663005520	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1284663005521	DNA-binding site [nucleotide binding]; DNA binding site
1284663005522	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1284663005523	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1284663005524	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1284663005525	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1284663005526	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1284663005527	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1284663005528	DNA binding residues [nucleotide binding]
1284663005529	DNA primase; Validated; Region: dnaG; PRK05667
1284663005530	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1284663005531	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1284663005532	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1284663005533	active site
1284663005534	metal binding site [ion binding]; metal-binding site
1284663005535	interdomain interaction site; other site
1284663005536	PE-PPE domain; Region: PE-PPE; pfam08237
1284663005537	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1284663005538	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1284663005539	dimer interface [polypeptide binding]; other site
1284663005540	motif 1; other site
1284663005541	active site
1284663005542	motif 2; other site
1284663005543	motif 3; other site
1284663005544	DNA repair protein RecO; Region: reco; TIGR00613
1284663005545	Recombination protein O N terminal; Region: RecO_N; pfam11967
1284663005546	Recombination protein O C terminal; Region: RecO_C; pfam02565
1284663005547	GTPase Era; Reviewed; Region: era; PRK00089
1284663005548	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1284663005549	G1 box; other site
1284663005550	GTP/Mg2+ binding site [chemical binding]; other site
1284663005551	Switch I region; other site
1284663005552	G2 box; other site
1284663005553	Switch II region; other site
1284663005554	G3 box; other site
1284663005555	G4 box; other site
1284663005556	G5 box; other site
1284663005557	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
1284663005558	metal-binding heat shock protein; Provisional; Region: PRK00016
1284663005559	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1284663005560	PhoH-like protein; Region: PhoH; pfam02562
1284663005561	Yqey-like protein; Region: YqeY; pfam09424
1284663005562	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1284663005563	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
1284663005564	short chain dehydrogenase; Provisional; Region: PRK07041
1284663005565	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663005566	NAD(P) binding site [chemical binding]; other site
1284663005567	active site
1284663005568	endonuclease IV; Provisional; Region: PRK01060
1284663005569	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1284663005570	AP (apurinic/apyrimidinic) site pocket; other site
1284663005571	DNA interaction; other site
1284663005572	Metal-binding active site; metal-binding site
1284663005573	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1284663005574	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1284663005575	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1284663005576	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1284663005577	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1284663005578	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1284663005579	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1284663005580	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1284663005581	dimer interface [polypeptide binding]; other site
1284663005582	anticodon binding site; other site
1284663005583	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1284663005584	homodimer interface [polypeptide binding]; other site
1284663005585	motif 1; other site
1284663005586	active site
1284663005587	motif 2; other site
1284663005588	GAD domain; Region: GAD; pfam02938
1284663005589	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1284663005590	active site
1284663005591	motif 3; other site
1284663005592	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1284663005593	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1284663005594	dimer interface [polypeptide binding]; other site
1284663005595	motif 1; other site
1284663005596	active site
1284663005597	motif 2; other site
1284663005598	motif 3; other site
1284663005599	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1284663005600	anticodon binding site; other site
1284663005601	Bacterial SH3 domain; Region: SH3_3; pfam08239
1284663005602	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1284663005603	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1284663005604	active site
1284663005605	metal binding site [ion binding]; metal-binding site
1284663005606	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1284663005607	Phosphotransferase enzyme family; Region: APH; pfam01636
1284663005608	active site
1284663005609	ATP binding site [chemical binding]; other site
1284663005610	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1284663005611	substrate binding site [chemical binding]; other site
1284663005612	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1284663005613	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663005614	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1284663005615	putative active site [active]
1284663005616	dimerization interface [polypeptide binding]; other site
1284663005617	putative tRNAtyr binding site [nucleotide binding]; other site
1284663005618	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1284663005619	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1284663005620	Zn2+ binding site [ion binding]; other site
1284663005621	Mg2+ binding site [ion binding]; other site
1284663005622	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1284663005623	synthetase active site [active]
1284663005624	NTP binding site [chemical binding]; other site
1284663005625	metal binding site [ion binding]; metal-binding site
1284663005626	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1284663005627	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1284663005628	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
1284663005629	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
1284663005630	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1284663005631	S-adenosylmethionine binding site [chemical binding]; other site
1284663005632	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1284663005633	active site
1284663005634	DNA binding site [nucleotide binding]
1284663005635	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1284663005636	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1284663005637	Int/Topo IB signature motif; other site
1284663005638	GTP-binding protein LepA; Provisional; Region: PRK05433
1284663005639	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1284663005640	G1 box; other site
1284663005641	putative GEF interaction site [polypeptide binding]; other site
1284663005642	GTP/Mg2+ binding site [chemical binding]; other site
1284663005643	Switch I region; other site
1284663005644	G2 box; other site
1284663005645	G3 box; other site
1284663005646	Switch II region; other site
1284663005647	G4 box; other site
1284663005648	G5 box; other site
1284663005649	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1284663005650	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1284663005651	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1284663005652	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
1284663005653	DltD N-terminal region; Region: DltD_N; pfam04915
1284663005654	DltD central region; Region: DltD_M; pfam04918
1284663005655	DltD C-terminal region; Region: DltD_C; pfam04914
1284663005656	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
1284663005657	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
1284663005658	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1284663005659	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1284663005660	acyl-activating enzyme (AAE) consensus motif; other site
1284663005661	AMP binding site [chemical binding]; other site
1284663005662	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
1284663005663	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1284663005664	Beta-lactamase; Region: Beta-lactamase; pfam00144
1284663005665	chaperone protein DnaJ; Provisional; Region: PRK14276
1284663005666	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1284663005667	HSP70 interaction site [polypeptide binding]; other site
1284663005668	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1284663005669	substrate binding site [polypeptide binding]; other site
1284663005670	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1284663005671	Zn binding sites [ion binding]; other site
1284663005672	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1284663005673	dimer interface [polypeptide binding]; other site
1284663005674	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1284663005675	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1284663005676	nucleotide binding site [chemical binding]; other site
1284663005677	GrpE; Region: GrpE; pfam01025
1284663005678	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1284663005679	dimer interface [polypeptide binding]; other site
1284663005680	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1284663005681	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1284663005682	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1284663005683	NLE (NUC135) domain; Region: NLE; pfam08154
1284663005684	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
1284663005685	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1284663005686	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1284663005687	active site
1284663005688	Riboflavin kinase; Region: Flavokinase; smart00904
1284663005689	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
1284663005690	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1284663005691	RNA binding site [nucleotide binding]; other site
1284663005692	active site
1284663005693	shikimate kinase; Reviewed; Region: aroK; PRK00131
1284663005694	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1284663005695	ADP binding site [chemical binding]; other site
1284663005696	magnesium binding site [ion binding]; other site
1284663005697	putative shikimate binding site; other site
1284663005698	prephenate dehydrogenase; Validated; Region: PRK06545
1284663005699	prephenate dehydrogenase; Validated; Region: PRK08507
1284663005700	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
1284663005701	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1284663005702	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1284663005703	hinge; other site
1284663005704	active site
1284663005705	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1284663005706	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1284663005707	Tetramer interface [polypeptide binding]; other site
1284663005708	active site
1284663005709	FMN-binding site [chemical binding]; other site
1284663005710	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663005711	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663005712	putative substrate translocation pore; other site
1284663005713	Chorismate mutase type II; Region: CM_2; pfam01817
1284663005714	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1284663005715	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1284663005716	translation initiation factor IF-2; Region: IF-2; TIGR00487
1284663005717	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1284663005718	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1284663005719	G1 box; other site
1284663005720	putative GEF interaction site [polypeptide binding]; other site
1284663005721	GTP/Mg2+ binding site [chemical binding]; other site
1284663005722	Switch I region; other site
1284663005723	G2 box; other site
1284663005724	G3 box; other site
1284663005725	Switch II region; other site
1284663005726	G4 box; other site
1284663005727	G5 box; other site
1284663005728	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1284663005729	Translation-initiation factor 2; Region: IF-2; pfam11987
1284663005730	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1284663005731	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
1284663005732	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1284663005733	putative RNA binding cleft [nucleotide binding]; other site
1284663005734	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1284663005735	NusA N-terminal domain; Region: NusA_N; pfam08529
1284663005736	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1284663005737	RNA binding site [nucleotide binding]; other site
1284663005738	homodimer interface [polypeptide binding]; other site
1284663005739	NusA-like KH domain; Region: KH_5; pfam13184
1284663005740	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1284663005741	G-X-X-G motif; other site
1284663005742	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1284663005743	Sm and related proteins; Region: Sm_like; cl00259
1284663005744	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1284663005745	putative oligomer interface [polypeptide binding]; other site
1284663005746	putative RNA binding site [nucleotide binding]; other site
1284663005747	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1284663005748	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1284663005749	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1284663005750	generic binding surface II; other site
1284663005751	generic binding surface I; other site
1284663005752	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1284663005753	active site
1284663005754	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1284663005755	active site
1284663005756	catalytic site [active]
1284663005757	substrate binding site [chemical binding]; other site
1284663005758	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1284663005759	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1284663005760	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1284663005761	dimer interface [polypeptide binding]; other site
1284663005762	motif 1; other site
1284663005763	active site
1284663005764	motif 2; other site
1284663005765	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1284663005766	putative deacylase active site [active]
1284663005767	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1284663005768	active site
1284663005769	motif 3; other site
1284663005770	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1284663005771	anticodon binding site; other site
1284663005772	RIP metalloprotease RseP; Region: TIGR00054
1284663005773	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1284663005774	active site
1284663005775	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1284663005776	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1284663005777	putative substrate binding region [chemical binding]; other site
1284663005778	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1284663005779	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1284663005780	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830
1284663005781	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1284663005782	catalytic residue [active]
1284663005783	putative FPP diphosphate  binding site; other site
1284663005784	putative FPP binding hydrophobic cleft; other site
1284663005785	dimer interface [polypeptide binding]; other site
1284663005786	putative IPP diphosphate binding site; other site
1284663005787	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1284663005788	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1284663005789	hinge region; other site
1284663005790	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1284663005791	putative nucleotide binding site [chemical binding]; other site
1284663005792	uridine monophosphate binding site [chemical binding]; other site
1284663005793	homohexameric interface [polypeptide binding]; other site
1284663005794	elongation factor Ts; Provisional; Region: tsf; PRK09377
1284663005795	UBA/TS-N domain; Region: UBA; pfam00627
1284663005796	Elongation factor TS; Region: EF_TS; pfam00889
1284663005797	Elongation factor TS; Region: EF_TS; pfam00889
1284663005798	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1284663005799	rRNA interaction site [nucleotide binding]; other site
1284663005800	S8 interaction site; other site
1284663005801	putative laminin-1 binding site; other site
1284663005802	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1284663005803	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663005804	motif II; other site
1284663005805	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
1284663005806	D-lactate dehydrogenase; Validated; Region: PRK08605
1284663005807	homodimer interface [polypeptide binding]; other site
1284663005808	ligand binding site [chemical binding]; other site
1284663005809	NAD binding site [chemical binding]; other site
1284663005810	catalytic site [active]
1284663005811	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1284663005812	GIY-YIG motif/motif A; other site
1284663005813	putative active site [active]
1284663005814	putative metal binding site [ion binding]; other site
1284663005815	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1284663005816	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1284663005817	S-adenosylmethionine binding site [chemical binding]; other site
1284663005818	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1284663005819	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1284663005820	putative acyl-acceptor binding pocket; other site
1284663005821	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
1284663005822	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
1284663005823	LexA repressor; Validated; Region: PRK00215
1284663005824	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1284663005825	putative DNA binding site [nucleotide binding]; other site
1284663005826	putative Zn2+ binding site [ion binding]; other site
1284663005827	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1284663005828	Catalytic site [active]
1284663005829	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
1284663005830	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
1284663005831	dimer interface [polypeptide binding]; other site
1284663005832	active site
1284663005833	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
1284663005834	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1284663005835	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1284663005836	Ligand binding site; other site
1284663005837	Putative Catalytic site; other site
1284663005838	DXD motif; other site
1284663005839	Helix-turn-helix domain; Region: HTH_28; pfam13518
1284663005840	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1284663005841	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1284663005842	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1284663005843	Walker A/P-loop; other site
1284663005844	ATP binding site [chemical binding]; other site
1284663005845	Q-loop/lid; other site
1284663005846	ABC transporter signature motif; other site
1284663005847	Walker B; other site
1284663005848	D-loop; other site
1284663005849	H-loop/switch region; other site
1284663005850	potential frameshift: common BLAST hit: Nitrate/sulfonate/bicarbonate ABC transporter,permease protein
1284663005851	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663005852	dimer interface [polypeptide binding]; other site
1284663005853	conserved gate region; other site
1284663005854	ABC-ATPase subunit interface; other site
1284663005855	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1284663005856	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1284663005857	Haemolysin XhlA; Region: XhlA; pfam10779
1284663005858	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
1284663005859	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1284663005860	active site
1284663005861	Bacterial SH3 domain; Region: SH3_5; pfam08460
1284663005862	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1284663005863	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1284663005864	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
1284663005865	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
1284663005866	Phage tail protein; Region: Sipho_tail; cl17486
1284663005867	Phage-related tail protein [Function unknown]; Region: COG5283
1284663005868	MAEBL; Provisional; Region: PTZ00121
1284663005869	Phage major tail protein; Region: Phage_tail; pfam04630
1284663005870	Protein of unknown function (DUF806); Region: DUF806; pfam05657
1284663005871	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
1284663005872	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
1284663005873	oligomerization interface [polypeptide binding]; other site
1284663005874	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1284663005875	Phage capsid family; Region: Phage_capsid; pfam05065
1284663005876	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
1284663005877	oligomer interface [polypeptide binding]; other site
1284663005878	active site residues [active]
1284663005879	Phage-related protein [Function unknown]; Region: COG4695
1284663005880	Phage portal protein; Region: Phage_portal; pfam04860
1284663005881	Protein of unknown function (DUF1056); Region: DUF1056; pfam06341
1284663005882	Phage Terminase; Region: Terminase_1; pfam03354
1284663005883	Phage terminase, small subunit; Region: Terminase_4; cl01525
1284663005884	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1284663005885	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1284663005886	active site
1284663005887	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
1284663005888	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
1284663005889	YopX protein; Region: YopX; pfam09643
1284663005890	HeH/LEM domain; Region: HeH; pfam12949
1284663005891	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1284663005892	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1284663005893	Walker A motif; other site
1284663005894	ATP binding site [chemical binding]; other site
1284663005895	Walker B motif; other site
1284663005896	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
1284663005897	ORF6C domain; Region: ORF6C; pfam10552
1284663005898	potential frameshift: common BLAST hit: Prophage protein, integrase
1284663005899	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1284663005900	Int/Topo IB signature motif; other site
1284663005901	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1284663005902	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1284663005903	hypothetical protein; Provisional; Region: PRK00967
1284663005904	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663005905	Helix-turn-helix domain; Region: HTH_20; pfam12840
1284663005906	dimerization interface [polypeptide binding]; other site
1284663005907	putative DNA binding site [nucleotide binding]; other site
1284663005908	putative Zn2+ binding site [ion binding]; other site
1284663005909	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1284663005910	active site
1284663005911	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1284663005912	DHH family; Region: DHH; pfam01368
1284663005913	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141
1284663005914	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1284663005915	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663005916	NAD(P) binding site [chemical binding]; other site
1284663005917	active site
1284663005918	ribonuclease Z; Region: RNase_Z; TIGR02651
1284663005919	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1284663005920	GTP1/OBG; Region: GTP1_OBG; pfam01018
1284663005921	Obg GTPase; Region: Obg; cd01898
1284663005922	G1 box; other site
1284663005923	GTP/Mg2+ binding site [chemical binding]; other site
1284663005924	Switch I region; other site
1284663005925	G2 box; other site
1284663005926	G3 box; other site
1284663005927	Switch II region; other site
1284663005928	G4 box; other site
1284663005929	G5 box; other site
1284663005930	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1284663005931	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1284663005932	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1284663005933	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1284663005934	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1284663005935	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1284663005936	putative substrate binding site [chemical binding]; other site
1284663005937	putative ATP binding site [chemical binding]; other site
1284663005938	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1284663005939	active site
1284663005940	phosphorylation site [posttranslational modification]
1284663005941	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1284663005942	active site
1284663005943	P-loop; other site
1284663005944	phosphorylation site [posttranslational modification]
1284663005945	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1284663005946	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1284663005947	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1284663005948	active site
1284663005949	metal binding site [ion binding]; metal-binding site
1284663005950	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1284663005951	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1284663005952	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1284663005953	Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111
1284663005954	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1284663005955	active site
1284663005956	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1284663005957	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1284663005958	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1284663005959	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1284663005960	putative ADP-binding pocket [chemical binding]; other site
1284663005961	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1284663005962	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1284663005963	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663005964	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1284663005965	NAD(P) binding site [chemical binding]; other site
1284663005966	active site
1284663005967	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1284663005968	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1284663005969	active site
1284663005970	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1284663005971	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1284663005972	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1284663005973	Chain length determinant protein; Region: Wzz; cl15801
1284663005974	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1284663005975	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1284663005976	GIY-YIG motif/motif A; other site
1284663005977	active site
1284663005978	catalytic site [active]
1284663005979	putative DNA binding site [nucleotide binding]; other site
1284663005980	metal binding site [ion binding]; metal-binding site
1284663005981	UvrB/uvrC motif; Region: UVR; pfam02151
1284663005982	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1284663005983	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
1284663005984	DNA binding site [nucleotide binding]
1284663005985	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1284663005986	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1284663005987	Walker A/P-loop; other site
1284663005988	ATP binding site [chemical binding]; other site
1284663005989	Q-loop/lid; other site
1284663005990	ABC transporter signature motif; other site
1284663005991	Walker B; other site
1284663005992	D-loop; other site
1284663005993	H-loop/switch region; other site
1284663005994	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1284663005995	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1284663005996	substrate binding pocket [chemical binding]; other site
1284663005997	membrane-bound complex binding site; other site
1284663005998	hinge residues; other site
1284663005999	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1284663006000	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663006001	dimer interface [polypeptide binding]; other site
1284663006002	conserved gate region; other site
1284663006003	putative PBP binding loops; other site
1284663006004	ABC-ATPase subunit interface; other site
1284663006005	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
1284663006006	putative metal binding site [ion binding]; other site
1284663006007	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1284663006008	G1 box; other site
1284663006009	GTP/Mg2+ binding site [chemical binding]; other site
1284663006010	Switch I region; other site
1284663006011	G2 box; other site
1284663006012	G3 box; other site
1284663006013	Switch II region; other site
1284663006014	G4 box; other site
1284663006015	G5 box; other site
1284663006016	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1284663006017	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1284663006018	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663006019	Walker A motif; other site
1284663006020	ATP binding site [chemical binding]; other site
1284663006021	Walker B motif; other site
1284663006022	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1284663006023	trigger factor; Provisional; Region: tig; PRK01490
1284663006024	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1284663006025	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1284663006026	elongation factor Tu; Reviewed; Region: PRK00049
1284663006027	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1284663006028	G1 box; other site
1284663006029	GEF interaction site [polypeptide binding]; other site
1284663006030	GTP/Mg2+ binding site [chemical binding]; other site
1284663006031	Switch I region; other site
1284663006032	G2 box; other site
1284663006033	G3 box; other site
1284663006034	Switch II region; other site
1284663006035	G4 box; other site
1284663006036	G5 box; other site
1284663006037	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1284663006038	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1284663006039	Antibiotic Binding Site [chemical binding]; other site
1284663006040	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1284663006041	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1284663006042	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1284663006043	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1284663006044	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1284663006045	dimer interface [polypeptide binding]; other site
1284663006046	active site
1284663006047	catalytic residue [active]
1284663006048	drug efflux system protein MdtG; Provisional; Region: PRK09874
1284663006049	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663006050	putative substrate translocation pore; other site
1284663006051	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1284663006052	16S/18S rRNA binding site [nucleotide binding]; other site
1284663006053	S13e-L30e interaction site [polypeptide binding]; other site
1284663006054	25S rRNA binding site [nucleotide binding]; other site
1284663006055	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1284663006056	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1284663006057	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1284663006058	potential frameshift: common BLAST hit: comEC
1284663006059	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1284663006060	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1284663006061	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1284663006062	Competence protein; Region: Competence; pfam03772
1284663006063	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1284663006064	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1284663006065	catalytic motif [active]
1284663006066	Zn binding site [ion binding]; other site
1284663006067	SLBB domain; Region: SLBB; pfam10531
1284663006068	comEA protein; Region: comE; TIGR01259
1284663006069	Helix-hairpin-helix motif; Region: HHH; pfam00633
1284663006070	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1284663006071	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1284663006072	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1284663006073	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1284663006074	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1284663006075	active site
1284663006076	(T/H)XGH motif; other site
1284663006077	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1284663006078	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1284663006079	S-adenosylmethionine binding site [chemical binding]; other site
1284663006080	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902
1284663006081	pyruvate carboxylase; Reviewed; Region: PRK12999
1284663006082	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1284663006083	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1284663006084	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1284663006085	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1284663006086	active site
1284663006087	catalytic residues [active]
1284663006088	metal binding site [ion binding]; metal-binding site
1284663006089	homodimer binding site [polypeptide binding]; other site
1284663006090	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1284663006091	carboxyltransferase (CT) interaction site; other site
1284663006092	biotinylation site [posttranslational modification]; other site
1284663006093	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1284663006094	conserved hypothetical integral membrane protein; Region: TIGR03766
1284663006095	potential frameshift: common BLAST hit: ica2
1284663006096	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
1284663006097	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1284663006098	DXD motif; other site
1284663006099	exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110
1284663006100	Firmicu-CTERM domain; Region: Firmicu_CTERM; TIGR04145
1284663006101	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1284663006102	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1284663006103	G1 box; other site
1284663006104	putative GEF interaction site [polypeptide binding]; other site
1284663006105	GTP/Mg2+ binding site [chemical binding]; other site
1284663006106	Switch I region; other site
1284663006107	G2 box; other site
1284663006108	G3 box; other site
1284663006109	Switch II region; other site
1284663006110	G4 box; other site
1284663006111	G5 box; other site
1284663006112	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1284663006113	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1284663006114	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1284663006115	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1284663006116	active site
1284663006117	Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256
1284663006118	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
1284663006119	substrate binding site [chemical binding]; other site
1284663006120	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1284663006121	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1284663006122	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1284663006123	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1284663006124	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1284663006125	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1284663006126	E3 interaction surface; other site
1284663006127	lipoyl attachment site [posttranslational modification]; other site
1284663006128	e3 binding domain; Region: E3_binding; pfam02817
1284663006129	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1284663006130	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1284663006131	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1284663006132	alpha subunit interface [polypeptide binding]; other site
1284663006133	TPP binding site [chemical binding]; other site
1284663006134	heterodimer interface [polypeptide binding]; other site
1284663006135	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1284663006136	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1284663006137	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1284663006138	TPP-binding site [chemical binding]; other site
1284663006139	heterodimer interface [polypeptide binding]; other site
1284663006140	tetramer interface [polypeptide binding]; other site
1284663006141	phosphorylation loop region [posttranslational modification]
1284663006142	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1284663006143	active site
1284663006144	catalytic residues [active]
1284663006145	metal binding site [ion binding]; metal-binding site
1284663006146	Protein of unknown function (DUF1447); Region: DUF1447; pfam07288
1284663006147	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1284663006148	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1284663006149	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1284663006150	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1284663006151	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1284663006152	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1284663006153	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1284663006154	NlpC/P60 family; Region: NLPC_P60; pfam00877
1284663006155	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1284663006156	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
1284663006157	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1284663006158	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1284663006159	active site
1284663006160	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1284663006161	AAA domain; Region: AAA_30; pfam13604
1284663006162	Family description; Region: UvrD_C_2; pfam13538
1284663006163	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1284663006164	binding surface
1284663006165	TPR motif; other site
1284663006166	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1284663006167	catalytic core [active]
1284663006168	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1284663006169	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1284663006170	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1284663006171	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1284663006172	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1284663006173	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1284663006174	TrkA-N domain; Region: TrkA_N; pfam02254
1284663006175	TrkA-C domain; Region: TrkA_C; pfam02080
1284663006176	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1284663006177	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1284663006178	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
1284663006179	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1284663006180	Putative amino acid metabolism; Region: DUF1831; pfam08866
1284663006181	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1284663006182	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1284663006183	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1284663006184	catalytic residue [active]
1284663006185	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1284663006186	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1284663006187	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1284663006188	dimer interface [polypeptide binding]; other site
1284663006189	ADP-ribose binding site [chemical binding]; other site
1284663006190	active site
1284663006191	nudix motif; other site
1284663006192	metal binding site [ion binding]; metal-binding site
1284663006193	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1284663006194	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1284663006195	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1284663006196	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1284663006197	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1284663006198	active site
1284663006199	HIGH motif; other site
1284663006200	nucleotide binding site [chemical binding]; other site
1284663006201	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1284663006202	active site
1284663006203	KMSKS motif; other site
1284663006204	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1284663006205	tRNA binding surface [nucleotide binding]; other site
1284663006206	anticodon binding site; other site
1284663006207	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1284663006208	DivIVA protein; Region: DivIVA; pfam05103
1284663006209	DivIVA domain; Region: DivI1A_domain; TIGR03544
1284663006210	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1284663006211	YGGT family; Region: YGGT; pfam02325
1284663006212	Protein of unknown function (DUF552); Region: DUF552; cl00775
1284663006213	cell division protein FtsZ; Validated; Region: PRK09330
1284663006214	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1284663006215	nucleotide binding site [chemical binding]; other site
1284663006216	SulA interaction site; other site
1284663006217	cell division protein FtsA; Region: ftsA; TIGR01174
1284663006218	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1284663006219	nucleotide binding site [chemical binding]; other site
1284663006220	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
1284663006221	Cell division protein FtsA; Region: FtsA; pfam14450
1284663006222	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
1284663006223	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1284663006224	Cell division protein FtsQ; Region: FtsQ; pfam03799
1284663006225	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1284663006226	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1284663006227	active site
1284663006228	homodimer interface [polypeptide binding]; other site
1284663006229	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1284663006230	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1284663006231	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1284663006232	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1284663006233	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1284663006234	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1284663006235	Mg++ binding site [ion binding]; other site
1284663006236	putative catalytic motif [active]
1284663006237	putative substrate binding site [chemical binding]; other site
1284663006238	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1284663006239	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1284663006240	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1284663006241	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1284663006242	cell division protein FtsL; Region: ftsL_broad; TIGR02209
1284663006243	MraW methylase family; Region: Methyltransf_5; pfam01795
1284663006244	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1284663006245	cell division protein MraZ; Reviewed; Region: PRK00326
1284663006246	MraZ protein; Region: MraZ; pfam02381
1284663006247	MraZ protein; Region: MraZ; pfam02381
1284663006248	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
1284663006249	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1284663006250	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1284663006251	Cl binding site [ion binding]; other site
1284663006252	oligomer interface [polypeptide binding]; other site
1284663006253	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1284663006254	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1284663006255	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1284663006256	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1284663006257	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1284663006258	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1284663006259	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1284663006260	NAD binding site [chemical binding]; other site
1284663006261	substrate binding site [chemical binding]; other site
1284663006262	putative active site [active]
1284663006263	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
1284663006264	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
1284663006265	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1284663006266	S-adenosylmethionine binding site [chemical binding]; other site
1284663006267	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1284663006268	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1284663006269	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1284663006270	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516
1284663006271	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1284663006272	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
1284663006273	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1284663006274	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1284663006275	active site
1284663006276	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
1284663006277	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1284663006278	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1284663006279	synthetase active site [active]
1284663006280	NTP binding site [chemical binding]; other site
1284663006281	metal binding site [ion binding]; metal-binding site
1284663006282	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
1284663006283	catalytic residues [active]
1284663006284	oligoendopeptidase F; Region: pepF; TIGR00181
1284663006285	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1284663006286	active site
1284663006287	Zn binding site [ion binding]; other site
1284663006288	Competence protein CoiA-like family; Region: CoiA; cl11541
1284663006289	adaptor protein; Provisional; Region: PRK02315
1284663006290	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1284663006291	ArsC family; Region: ArsC; pfam03960
1284663006292	putative catalytic residues [active]
1284663006293	thiol/disulfide switch; other site
1284663006294	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1284663006295	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1284663006296	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
1284663006297	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1284663006298	RNA binding site [nucleotide binding]; other site
1284663006299	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1284663006300	active site
1284663006301	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1284663006302	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1284663006303	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
1284663006304	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
1284663006305	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663006306	active site
1284663006307	motif I; other site
1284663006308	motif II; other site
1284663006309	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663006310	Protein of unknown function (DUF1027); Region: DUF1027; pfam06265
1284663006311	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1284663006312	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1284663006313	active site
1284663006314	metal binding site [ion binding]; metal-binding site
1284663006315	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1284663006316	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
1284663006317	putative active site [active]
1284663006318	putative metal binding site [ion binding]; other site
1284663006319	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1284663006320	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1284663006321	propionate/acetate kinase; Provisional; Region: PRK12379
1284663006322	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1284663006323	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1284663006324	S-adenosylmethionine binding site [chemical binding]; other site
1284663006325	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
1284663006326	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
1284663006327	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1284663006328	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1284663006329	Type II/IV secretion system protein; Region: T2SE; pfam00437
1284663006330	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1284663006331	Walker A motif; other site
1284663006332	ATP binding site [chemical binding]; other site
1284663006333	Walker B motif; other site
1284663006334	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1284663006335	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1284663006336	substrate binding site [chemical binding]; other site
1284663006337	dimer interface [polypeptide binding]; other site
1284663006338	ATP binding site [chemical binding]; other site
1284663006339	hypothetical protein; Validated; Region: PRK00110
1284663006340	DsrE/DsrF-like family; Region: DrsE; cl00672
1284663006341	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1284663006342	catabolite control protein A; Region: ccpA; TIGR01481
1284663006343	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1284663006344	DNA binding site [nucleotide binding]
1284663006345	domain linker motif; other site
1284663006346	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1284663006347	dimerization interface [polypeptide binding]; other site
1284663006348	effector binding site; other site
1284663006349	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1284663006350	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1284663006351	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1284663006352	active site
1284663006353	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1284663006354	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1284663006355	DNA binding residues [nucleotide binding]
1284663006356	putative dimer interface [polypeptide binding]; other site
1284663006357	Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103
1284663006358	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1284663006359	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1284663006360	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1284663006361	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
1284663006362	metal binding site [ion binding]; metal-binding site
1284663006363	putative dimer interface [polypeptide binding]; other site
1284663006364	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
1284663006365	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
1284663006366	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1284663006367	active site
1284663006368	trimer interface [polypeptide binding]; other site
1284663006369	substrate binding site [chemical binding]; other site
1284663006370	CoA binding site [chemical binding]; other site
1284663006371	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
1284663006372	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1284663006373	active site
1284663006374	metal binding site [ion binding]; metal-binding site
1284663006375	homotetramer interface [polypeptide binding]; other site
1284663006376	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1284663006377	active site
1284663006378	dimerization interface [polypeptide binding]; other site
1284663006379	glutamate racemase; Provisional; Region: PRK00865
1284663006380	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
1284663006381	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1284663006382	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1284663006383	catalytic residues [active]
1284663006384	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1284663006385	MutS domain III; Region: MutS_III; pfam05192
1284663006386	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663006387	Walker A/P-loop; other site
1284663006388	ATP binding site [chemical binding]; other site
1284663006389	Q-loop/lid; other site
1284663006390	ABC transporter signature motif; other site
1284663006391	Walker B; other site
1284663006392	D-loop; other site
1284663006393	H-loop/switch region; other site
1284663006394	Smr domain; Region: Smr; pfam01713
1284663006395	Cell division protein ZapA; Region: ZapA; cl01146
1284663006396	hypothetical protein; Provisional; Region: PRK13678
1284663006397	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1284663006398	hypothetical protein; Provisional; Region: PRK05473
1284663006399	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1284663006400	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1284663006401	motif 1; other site
1284663006402	active site
1284663006403	motif 2; other site
1284663006404	motif 3; other site
1284663006405	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1284663006406	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1284663006407	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1284663006408	ATP binding site [chemical binding]; other site
1284663006409	Mg++ binding site [ion binding]; other site
1284663006410	motif III; other site
1284663006411	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1284663006412	nucleotide binding region [chemical binding]; other site
1284663006413	ATP-binding site [chemical binding]; other site
1284663006414	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1284663006415	DHH family; Region: DHH; pfam01368
1284663006416	DHHA1 domain; Region: DHHA1; pfam02272
1284663006417	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1284663006418	active site
1284663006419	DNA polymerase IV; Validated; Region: PRK02406
1284663006420	DNA binding site [nucleotide binding]
1284663006421	Preprotein translocase subunit; Region: YajC; pfam02699
1284663006422	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1284663006423	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1284663006424	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1284663006425	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1284663006426	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1284663006427	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663006428	Walker A motif; other site
1284663006429	ATP binding site [chemical binding]; other site
1284663006430	Walker B motif; other site
1284663006431	arginine finger; other site
1284663006432	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1284663006433	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1284663006434	RuvA N terminal domain; Region: RuvA_N; pfam01330
1284663006435	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
1284663006436	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
1284663006437	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1284663006438	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1284663006439	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1284663006440	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
1284663006441	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1284663006442	ATP binding site [chemical binding]; other site
1284663006443	Mg2+ binding site [ion binding]; other site
1284663006444	G-X-G motif; other site
1284663006445	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1284663006446	ATP binding site [chemical binding]; other site
1284663006447	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1284663006448	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1284663006449	MutS domain I; Region: MutS_I; pfam01624
1284663006450	MutS domain II; Region: MutS_II; pfam05188
1284663006451	MutS domain III; Region: MutS_III; pfam05192
1284663006452	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1284663006453	Walker A/P-loop; other site
1284663006454	ATP binding site [chemical binding]; other site
1284663006455	Q-loop/lid; other site
1284663006456	ABC transporter signature motif; other site
1284663006457	Walker B; other site
1284663006458	D-loop; other site
1284663006459	H-loop/switch region; other site
1284663006460	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1284663006461	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1284663006462	putative active site [active]
1284663006463	metal binding site [ion binding]; metal-binding site
1284663006464	homodimer binding site [polypeptide binding]; other site
1284663006465	ribonuclease Y; Region: RNase_Y; TIGR03319
1284663006466	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1284663006467	Zn2+ binding site [ion binding]; other site
1284663006468	Mg2+ binding site [ion binding]; other site
1284663006469	recombinase A; Provisional; Region: recA; PRK09354
1284663006470	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1284663006471	hexamer interface [polypeptide binding]; other site
1284663006472	Walker A motif; other site
1284663006473	ATP binding site [chemical binding]; other site
1284663006474	Walker B motif; other site
1284663006475	competence damage-inducible protein A; Provisional; Region: PRK00549
1284663006476	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1284663006477	putative MPT binding site; other site
1284663006478	Competence-damaged protein; Region: CinA; pfam02464
1284663006479	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1284663006480	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1284663006481	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663006482	non-specific DNA binding site [nucleotide binding]; other site
1284663006483	salt bridge; other site
1284663006484	sequence-specific DNA binding site [nucleotide binding]; other site
1284663006485	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1284663006486	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1284663006487	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1284663006488	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1284663006489	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1284663006490	aspartate kinase; Reviewed; Region: PRK09034
1284663006491	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
1284663006492	putative catalytic residues [active]
1284663006493	putative nucleotide binding site [chemical binding]; other site
1284663006494	putative aspartate binding site [chemical binding]; other site
1284663006495	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
1284663006496	allosteric regulatory residue; other site
1284663006497	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
1284663006498	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1284663006499	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1284663006500	substrate binding pocket [chemical binding]; other site
1284663006501	membrane-bound complex binding site; other site
1284663006502	hinge residues; other site
1284663006503	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1284663006504	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663006505	Walker A/P-loop; other site
1284663006506	ATP binding site [chemical binding]; other site
1284663006507	Q-loop/lid; other site
1284663006508	ABC transporter signature motif; other site
1284663006509	Walker B; other site
1284663006510	D-loop; other site
1284663006511	H-loop/switch region; other site
1284663006512	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1284663006513	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663006514	dimer interface [polypeptide binding]; other site
1284663006515	conserved gate region; other site
1284663006516	putative PBP binding loops; other site
1284663006517	ABC-ATPase subunit interface; other site
1284663006518	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
1284663006519	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1284663006520	Switch I; other site
1284663006521	Switch II; other site
1284663006522	septum formation inhibitor; Reviewed; Region: minC; PRK00513
1284663006523	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1284663006524	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
1284663006525	rod shape-determining protein MreC; Provisional; Region: PRK13922
1284663006526	rod shape-determining protein MreC; Region: MreC; pfam04085
1284663006527	rod shape-determining protein MreB; Provisional; Region: PRK13927
1284663006528	MreB and similar proteins; Region: MreB_like; cd10225
1284663006529	nucleotide binding site [chemical binding]; other site
1284663006530	Mg binding site [ion binding]; other site
1284663006531	putative protofilament interaction site [polypeptide binding]; other site
1284663006532	RodZ interaction site [polypeptide binding]; other site
1284663006533	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1284663006534	MPN+ (JAMM) motif; other site
1284663006535	Zinc-binding site [ion binding]; other site
1284663006536	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
1284663006537	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1284663006538	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1284663006539	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1284663006540	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1284663006541	active site
1284663006542	HIGH motif; other site
1284663006543	nucleotide binding site [chemical binding]; other site
1284663006544	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1284663006545	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1284663006546	active site
1284663006547	KMSKS motif; other site
1284663006548	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1284663006549	tRNA binding surface [nucleotide binding]; other site
1284663006550	anticodon binding site; other site
1284663006551	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1284663006552	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1284663006553	dimer interface [polypeptide binding]; other site
1284663006554	catalytic triad [active]
1284663006555	peroxidatic and resolving cysteines [active]
1284663006556	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
1284663006557	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
1284663006558	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1284663006559	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1284663006560	Ligand Binding Site [chemical binding]; other site
1284663006561	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1284663006562	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1284663006563	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1284663006564	catalytic residue [active]
1284663006565	Septation ring formation regulator, EzrA; Region: EzrA; pfam06160
1284663006566	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1284663006567	GAF domain; Region: GAF_2; pfam13185
1284663006568	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1284663006569	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1284663006570	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1284663006571	RNA binding surface [nucleotide binding]; other site
1284663006572	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
1284663006573	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
1284663006574	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
1284663006575	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1284663006576	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1284663006577	dimerization interface [polypeptide binding]; other site
1284663006578	putative DNA binding site [nucleotide binding]; other site
1284663006579	putative Zn2+ binding site [ion binding]; other site
1284663006580	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
1284663006581	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
1284663006582	recombination factor protein RarA; Reviewed; Region: PRK13342
1284663006583	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1284663006584	Walker A motif; other site
1284663006585	ATP binding site [chemical binding]; other site
1284663006586	Walker B motif; other site
1284663006587	arginine finger; other site
1284663006588	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1284663006589	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1284663006590	Ligand Binding Site [chemical binding]; other site
1284663006591	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1284663006592	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1284663006593	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1284663006594	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
1284663006595	putative active site [active]
1284663006596	catalytic site [active]
1284663006597	putative metal binding site [ion binding]; other site
1284663006598	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1284663006599	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1284663006600	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1284663006601	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1284663006602	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1284663006603	putative NAD(P) binding site [chemical binding]; other site
1284663006604	dimer interface [polypeptide binding]; other site
1284663006605	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
1284663006606	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1284663006607	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1284663006608	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
1284663006609	NAD binding site [chemical binding]; other site
1284663006610	dimer interface [polypeptide binding]; other site
1284663006611	substrate binding site [chemical binding]; other site
1284663006612	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1284663006613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663006614	dimer interface [polypeptide binding]; other site
1284663006615	conserved gate region; other site
1284663006616	ABC-ATPase subunit interface; other site
1284663006617	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1284663006618	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1284663006619	Walker A/P-loop; other site
1284663006620	ATP binding site [chemical binding]; other site
1284663006621	Q-loop/lid; other site
1284663006622	ABC transporter signature motif; other site
1284663006623	Walker B; other site
1284663006624	D-loop; other site
1284663006625	H-loop/switch region; other site
1284663006626	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1284663006627	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1284663006628	lipoyl attachment site [posttranslational modification]; other site
1284663006629	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1284663006630	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
1284663006631	hypothetical protein; Validated; Region: PRK00041
1284663006632	rod shape-determining protein MreB; Provisional; Region: PRK13930
1284663006633	MreB and similar proteins; Region: MreB_like; cd10225
1284663006634	nucleotide binding site [chemical binding]; other site
1284663006635	Mg binding site [ion binding]; other site
1284663006636	putative protofilament interaction site [polypeptide binding]; other site
1284663006637	RodZ interaction site [polypeptide binding]; other site
1284663006638	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1284663006639	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1284663006640	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1284663006641	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1284663006642	hinge; other site
1284663006643	active site
1284663006644	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1284663006645	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1284663006646	gamma subunit interface [polypeptide binding]; other site
1284663006647	epsilon subunit interface [polypeptide binding]; other site
1284663006648	LBP interface [polypeptide binding]; other site
1284663006649	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1284663006650	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1284663006651	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1284663006652	alpha subunit interaction interface [polypeptide binding]; other site
1284663006653	Walker A motif; other site
1284663006654	ATP binding site [chemical binding]; other site
1284663006655	Walker B motif; other site
1284663006656	inhibitor binding site; inhibition site
1284663006657	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1284663006658	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1284663006659	core domain interface [polypeptide binding]; other site
1284663006660	delta subunit interface [polypeptide binding]; other site
1284663006661	epsilon subunit interface [polypeptide binding]; other site
1284663006662	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1284663006663	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1284663006664	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1284663006665	beta subunit interaction interface [polypeptide binding]; other site
1284663006666	Walker A motif; other site
1284663006667	ATP binding site [chemical binding]; other site
1284663006668	Walker B motif; other site
1284663006669	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1284663006670	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1284663006671	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1284663006672	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1284663006673	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1284663006674	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1284663006675	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1284663006676	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1284663006677	uracil transporter; Provisional; Region: PRK10720
1284663006678	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1284663006679	active site
1284663006680	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1284663006681	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1284663006682	dimer interface [polypeptide binding]; other site
1284663006683	active site
1284663006684	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1284663006685	folate binding site [chemical binding]; other site
1284663006686	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1284663006687	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1284663006688	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
1284663006689	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1284663006690	S-adenosylmethionine binding site [chemical binding]; other site
1284663006691	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1284663006692	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1284663006693	RF-1 domain; Region: RF-1; pfam00472
1284663006694	thymidine kinase; Provisional; Region: PRK04296
1284663006695	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1284663006696	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1284663006697	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1284663006698	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1284663006699	catalytic triad [active]
1284663006700	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1284663006701	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1284663006702	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1284663006703	Beta-lactamase; Region: Beta-lactamase; pfam00144
1284663006704	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1284663006705	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1284663006706	homodimer interface [polypeptide binding]; other site
1284663006707	substrate-cofactor binding pocket; other site
1284663006708	catalytic residue [active]
1284663006709	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1284663006710	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1284663006711	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663006712	Walker A/P-loop; other site
1284663006713	ATP binding site [chemical binding]; other site
1284663006714	Q-loop/lid; other site
1284663006715	ABC transporter signature motif; other site
1284663006716	Walker B; other site
1284663006717	D-loop; other site
1284663006718	H-loop/switch region; other site
1284663006719	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1284663006720	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1284663006721	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663006722	Walker A/P-loop; other site
1284663006723	ATP binding site [chemical binding]; other site
1284663006724	Q-loop/lid; other site
1284663006725	ABC transporter signature motif; other site
1284663006726	Walker B; other site
1284663006727	D-loop; other site
1284663006728	H-loop/switch region; other site
1284663006729	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1284663006730	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1284663006731	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1284663006732	putative active site [active]
1284663006733	putative metal binding site [ion binding]; other site
1284663006734	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
1284663006735	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1284663006736	active site
1284663006737	Bacterial SH3 domain; Region: SH3_5; pfam08460
1284663006738	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1284663006739	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1284663006740	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900
1284663006741	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
1284663006742	Phage tail protein; Region: Sipho_tail; cl17486
1284663006743	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
1284663006744	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1284663006745	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1284663006746	catalytic residue [active]
1284663006747	Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854
1284663006748	Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691
1284663006749	Minor capsid protein; Region: Minor_capsid_1; pfam10665
1284663006750	Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049
1284663006751	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1284663006752	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
1284663006753	phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542
1284663006754	Phage terminase large subunit; Region: Terminase_3; cl12054
1284663006755	Homeodomain-like domain; Region: HTH_23; pfam13384
1284663006756	endopeptidase Clp ATP-binding regulatory subunit (clpX); Region: clpX; TIGR00382
1284663006757	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
1284663006758	Probable pectinesterase/pectinesterase inhibitor; Region: PLN02713
1284663006759	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
1284663006760	Helix-turn-helix domain; Region: HTH_36; pfam13730
1284663006761	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
1284663006762	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
1284663006763	RecT family; Region: RecT; pfam03837
1284663006764	PcfK-like protein; Region: PcfK; pfam14058
1284663006765	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1284663006766	Domain of unknown function (DUF771); Region: DUF771; cl09962
1284663006767	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1284663006768	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663006769	non-specific DNA binding site [nucleotide binding]; other site
1284663006770	salt bridge; other site
1284663006771	sequence-specific DNA binding site [nucleotide binding]; other site
1284663006772	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1284663006773	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1284663006774	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
1284663006775	P-loop; other site
1284663006776	Magnesium ion binding site [ion binding]; other site
1284663006777	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1284663006778	Magnesium ion binding site [ion binding]; other site
1284663006779	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1284663006780	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1284663006781	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1284663006782	Int/Topo IB signature motif; other site
1284663006783	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1284663006784	MarR family; Region: MarR_2; pfam12802
1284663006785	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1284663006786	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1284663006787	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663006788	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663006789	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663006790	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663006791	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663006792	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1284663006793	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1284663006794	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663006795	Walker A/P-loop; other site
1284663006796	ATP binding site [chemical binding]; other site
1284663006797	Q-loop/lid; other site
1284663006798	ABC transporter signature motif; other site
1284663006799	Walker B; other site
1284663006800	D-loop; other site
1284663006801	H-loop/switch region; other site
1284663006802	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1284663006803	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1284663006804	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1284663006805	potential frameshift: common BLAST hit: ABC transporter, ATP-binding and permease protein
1284663006806	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1284663006807	FtsX-like permease family; Region: FtsX; pfam02687
1284663006808	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1284663006809	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1284663006810	Walker A/P-loop; other site
1284663006811	ATP binding site [chemical binding]; other site
1284663006812	Q-loop/lid; other site
1284663006813	ABC transporter signature motif; other site
1284663006814	Walker B; other site
1284663006815	D-loop; other site
1284663006816	H-loop/switch region; other site
1284663006817	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1284663006818	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1284663006819	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1284663006820	active site
1284663006821	dimer interface [polypeptide binding]; other site
1284663006822	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1284663006823	dimer interface [polypeptide binding]; other site
1284663006824	active site
1284663006825	Sugar transport protein; Region: Sugar_transport; pfam06800
1284663006826	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1284663006827	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1284663006828	putative RNA binding site [nucleotide binding]; other site
1284663006829	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1284663006830	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1284663006831	dimerization interface [polypeptide binding]; other site
1284663006832	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1284663006833	dimer interface [polypeptide binding]; other site
1284663006834	phosphorylation site [posttranslational modification]
1284663006835	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1284663006836	ATP binding site [chemical binding]; other site
1284663006837	Mg2+ binding site [ion binding]; other site
1284663006838	G-X-G motif; other site
1284663006839	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1284663006840	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1284663006841	active site
1284663006842	phosphorylation site [posttranslational modification]
1284663006843	intermolecular recognition site; other site
1284663006844	dimerization interface [polypeptide binding]; other site
1284663006845	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1284663006846	DNA binding site [nucleotide binding]
1284663006847	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
1284663006848	hypothetical protein; Validated; Region: PRK00194
1284663006849	EamA-like transporter family; Region: EamA; pfam00892
1284663006850	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1284663006851	EamA-like transporter family; Region: EamA; cl17759
1284663006852	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
1284663006853	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663006854	benzoate transport; Region: 2A0115; TIGR00895
1284663006855	putative substrate translocation pore; other site
1284663006856	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
1284663006857	nudix motif; other site
1284663006858	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
1284663006859	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1284663006860	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1284663006861	NlpC/P60 family; Region: NLPC_P60; pfam00877
1284663006862	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1284663006863	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1284663006864	putative DNA binding site [nucleotide binding]; other site
1284663006865	putative Zn2+ binding site [ion binding]; other site
1284663006866	AsnC family; Region: AsnC_trans_reg; pfam01037
1284663006867	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1284663006868	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1284663006869	metal binding site [ion binding]; metal-binding site
1284663006870	active site
1284663006871	I-site; other site
1284663006872	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1284663006873	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1284663006874	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1284663006875	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1284663006876	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663006877	Walker A/P-loop; other site
1284663006878	ATP binding site [chemical binding]; other site
1284663006879	Q-loop/lid; other site
1284663006880	ABC transporter signature motif; other site
1284663006881	Walker B; other site
1284663006882	D-loop; other site
1284663006883	H-loop/switch region; other site
1284663006884	ABC transporter; Region: ABC_tran_2; pfam12848
1284663006885	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1284663006886	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663006887	Coenzyme A binding pocket [chemical binding]; other site
1284663006888	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
1284663006889	dimer interface [polypeptide binding]; other site
1284663006890	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1284663006891	metal binding site [ion binding]; metal-binding site
1284663006892	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1284663006893	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1284663006894	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1284663006895	active site turn [active]
1284663006896	phosphorylation site [posttranslational modification]
1284663006897	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1284663006898	HPr interaction site; other site
1284663006899	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1284663006900	active site
1284663006901	phosphorylation site [posttranslational modification]
1284663006902	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1284663006903	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1284663006904	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1284663006905	EDD domain protein, DegV family; Region: DegV; TIGR00762
1284663006906	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1284663006907	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
1284663006908	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1284663006909	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1284663006910	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
1284663006911	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1284663006912	homodimer interface [polypeptide binding]; other site
1284663006913	substrate-cofactor binding pocket; other site
1284663006914	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663006915	catalytic residue [active]
1284663006916	Homoserine O-succinyltransferase; Region: HTS; pfam04204
1284663006917	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1284663006918	proposed active site lysine [active]
1284663006919	conserved cys residue [active]
1284663006920	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1284663006921	zinc binding site [ion binding]; other site
1284663006922	putative ligand binding site [chemical binding]; other site
1284663006923	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1284663006924	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1284663006925	TM-ABC transporter signature motif; other site
1284663006926	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
1284663006927	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663006928	Walker A/P-loop; other site
1284663006929	ATP binding site [chemical binding]; other site
1284663006930	Q-loop/lid; other site
1284663006931	ABC transporter signature motif; other site
1284663006932	Walker B; other site
1284663006933	D-loop; other site
1284663006934	H-loop/switch region; other site
1284663006935	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
1284663006936	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1284663006937	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1284663006938	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1284663006939	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1284663006940	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1284663006941	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
1284663006942	maltose O-acetyltransferase; Provisional; Region: PRK10092
1284663006943	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1284663006944	active site
1284663006945	substrate binding site [chemical binding]; other site
1284663006946	trimer interface [polypeptide binding]; other site
1284663006947	CoA binding site [chemical binding]; other site
1284663006948	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
1284663006949	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1284663006950	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663006951	homodimer interface [polypeptide binding]; other site
1284663006952	catalytic residue [active]
1284663006953	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1284663006954	metal binding site [ion binding]; metal-binding site
1284663006955	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; pfam01502
1284663006956	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1284663006957	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1284663006958	substrate binding site [chemical binding]; other site
1284663006959	glutamase interaction surface [polypeptide binding]; other site
1284663006960	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1284663006961	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1284663006962	catalytic residues [active]
1284663006963	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
1284663006964	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1284663006965	putative active site [active]
1284663006966	oxyanion strand; other site
1284663006967	catalytic triad [active]
1284663006968	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1284663006969	putative active site pocket [active]
1284663006970	4-fold oligomerization interface [polypeptide binding]; other site
1284663006971	metal binding residues [ion binding]; metal-binding site
1284663006972	3-fold/trimer interface [polypeptide binding]; other site
1284663006973	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1284663006974	histidinol dehydrogenase; Region: hisD; TIGR00069
1284663006975	NAD binding site [chemical binding]; other site
1284663006976	dimerization interface [polypeptide binding]; other site
1284663006977	product binding site; other site
1284663006978	substrate binding site [chemical binding]; other site
1284663006979	zinc binding site [ion binding]; other site
1284663006980	catalytic residues [active]
1284663006981	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1284663006982	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1284663006983	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
1284663006984	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1284663006985	dimer interface [polypeptide binding]; other site
1284663006986	motif 1; other site
1284663006987	active site
1284663006988	motif 2; other site
1284663006989	motif 3; other site
1284663006990	histidinol-phosphatase; Reviewed; Region: PRK08123
1284663006991	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
1284663006992	active site
1284663006993	dimer interface [polypeptide binding]; other site
1284663006994	VanZ like family; Region: VanZ; pfam04892
1284663006995	RDD family; Region: RDD; pfam06271
1284663006996	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1284663006997	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1284663006998	Cl binding site [ion binding]; other site
1284663006999	oligomer interface [polypeptide binding]; other site
1284663007000	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1284663007001	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1284663007002	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1284663007003	DNA binding residues [nucleotide binding]
1284663007004	putative dimer interface [polypeptide binding]; other site
1284663007005	short chain dehydrogenase; Provisional; Region: PRK06180
1284663007006	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1284663007007	NADP binding site [chemical binding]; other site
1284663007008	active site
1284663007009	steroid binding site; other site
1284663007010	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1284663007011	hydrophobic ligand binding site; other site
1284663007012	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1284663007013	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1284663007014	Peptidase M15; Region: Peptidase_M15_3; cl01194
1284663007015	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1284663007016	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
1284663007017	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1284663007018	potential frameshift: common BLAST hit: Cell surface protein
1284663007019	Collagen binding domain; Region: Collagen_bind; pfam05737
1284663007020	Cna protein B-type domain; Region: Cna_B; pfam05738
1284663007021	Cna protein B-type domain; Region: Cna_B; pfam05738
1284663007022	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663007023	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1284663007024	Coenzyme A binding pocket [chemical binding]; other site
1284663007025	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1284663007026	Sulfatase; Region: Sulfatase; pfam00884
1284663007027	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110
1284663007028	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1284663007029	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
1284663007030	putative active site [active]
1284663007031	catalytic site [active]
1284663007032	putative metal binding site [ion binding]; other site
1284663007033	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1284663007034	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1284663007035	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1284663007036	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1284663007037	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
1284663007038	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
1284663007039	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1284663007040	dimer interface [polypeptide binding]; other site
1284663007041	FMN binding site [chemical binding]; other site
1284663007042	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
1284663007043	active site
1284663007044	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
1284663007045	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1284663007046	RNA/DNA hybrid binding site [nucleotide binding]; other site
1284663007047	active site
1284663007048	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663007049	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1284663007050	active site
1284663007051	motif I; other site
1284663007052	motif II; other site
1284663007053	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663007054	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1284663007055	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1284663007056	DNA binding site [nucleotide binding]
1284663007057	domain linker motif; other site
1284663007058	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1284663007059	putative dimerization interface [polypeptide binding]; other site
1284663007060	putative ligand binding site [chemical binding]; other site
1284663007061	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1284663007062	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1284663007063	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1284663007064	putative active site [active]
1284663007065	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1284663007066	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1284663007067	putative oxidoreductase; Provisional; Region: PRK10206
1284663007068	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1284663007069	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1284663007070	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1284663007071	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1284663007072	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315
1284663007073	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1284663007074	TPP-binding site; other site
1284663007075	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1284663007076	PYR/PP interface [polypeptide binding]; other site
1284663007077	dimer interface [polypeptide binding]; other site
1284663007078	TPP binding site [chemical binding]; other site
1284663007079	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1284663007080	Isochorismatase family; Region: Isochorismatase; pfam00857
1284663007081	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1284663007082	catalytic triad [active]
1284663007083	conserved cis-peptide bond; other site
1284663007084	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1284663007085	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663007086	Walker A/P-loop; other site
1284663007087	ATP binding site [chemical binding]; other site
1284663007088	Q-loop/lid; other site
1284663007089	ABC transporter signature motif; other site
1284663007090	Walker B; other site
1284663007091	D-loop; other site
1284663007092	H-loop/switch region; other site
1284663007093	Predicted transcriptional regulators [Transcription]; Region: COG1725
1284663007094	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1284663007095	DNA-binding site [nucleotide binding]; DNA binding site
1284663007096	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1284663007097	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1284663007098	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
1284663007099	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
1284663007100	active site
1284663007101	Zn binding site [ion binding]; other site
1284663007102	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1284663007103	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663007104	non-specific DNA binding site [nucleotide binding]; other site
1284663007105	salt bridge; other site
1284663007106	sequence-specific DNA binding site [nucleotide binding]; other site
1284663007107	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
1284663007108	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1284663007109	PYR/PP interface [polypeptide binding]; other site
1284663007110	dimer interface [polypeptide binding]; other site
1284663007111	tetramer interface [polypeptide binding]; other site
1284663007112	TPP binding site [chemical binding]; other site
1284663007113	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1284663007114	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1284663007115	TPP-binding site [chemical binding]; other site
1284663007116	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1284663007117	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1284663007118	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1284663007119	catalytic residues [active]
1284663007120	cystathionine gamma-synthase; Reviewed; Region: PRK08247
1284663007121	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1284663007122	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1284663007123	catalytic residue [active]
1284663007124	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
1284663007125	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1284663007126	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1284663007127	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1284663007128	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1284663007129	Bacterial SH3 domain; Region: SH3_5; pfam08460
1284663007130	Bacterial SH3 domain; Region: SH3_5; pfam08460
1284663007131	Bacterial SH3 domain; Region: SH3_5; pfam08460
1284663007132	Bacterial SH3 domain; Region: SH3_5; pfam08460
1284663007133	Bacterial SH3 domain; Region: SH3_5; pfam08460
1284663007134	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1284663007135	active pocket/dimerization site; other site
1284663007136	active site
1284663007137	phosphorylation site [posttranslational modification]
1284663007138	PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855
1284663007139	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
1284663007140	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1284663007141	active site
1284663007142	phosphorylation site [posttranslational modification]
1284663007143	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1284663007144	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1284663007145	DNA-binding site [nucleotide binding]; DNA binding site
1284663007146	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1284663007147	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1284663007148	Ligand Binding Site [chemical binding]; other site
1284663007149	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1284663007150	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1284663007151	active site
1284663007152	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1284663007153	Double zinc ribbon; Region: DZR; pfam12773
1284663007154	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1284663007155	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663007156	non-specific DNA binding site [nucleotide binding]; other site
1284663007157	salt bridge; other site
1284663007158	sequence-specific DNA binding site [nucleotide binding]; other site
1284663007159	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1284663007160	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
1284663007161	putative ADP-binding pocket [chemical binding]; other site
1284663007162	putative phosphoketolase; Provisional; Region: PRK05261
1284663007163	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
1284663007164	TPP-binding site; other site
1284663007165	XFP C-terminal domain; Region: XFP_C; pfam09363
1284663007166	Predicted esterase [General function prediction only]; Region: COG0627
1284663007167	S-formylglutathione hydrolase; Region: PLN02442
1284663007168	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1284663007169	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1284663007170	DNA-binding site [nucleotide binding]; DNA binding site
1284663007171	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1284663007172	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1284663007173	putative deacylase active site [active]
1284663007174	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1284663007175	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
1284663007176	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1284663007177	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1284663007178	active site
1284663007179	phosphorylation site [posttranslational modification]
1284663007180	intermolecular recognition site; other site
1284663007181	dimerization interface [polypeptide binding]; other site
1284663007182	LytTr DNA-binding domain; Region: LytTR; pfam04397
1284663007183	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
1284663007184	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1284663007185	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
1284663007186	putative dimer interface [polypeptide binding]; other site
1284663007187	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1284663007188	Domain of unknown function DUF21; Region: DUF21; pfam01595
1284663007189	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1284663007190	Transporter associated domain; Region: CorC_HlyC; smart01091
1284663007191	flavoprotein NrdI; Provisional; Region: PRK02551
1284663007192	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1284663007193	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1284663007194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663007195	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663007196	putative substrate translocation pore; other site
1284663007197	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1284663007198	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1284663007199	DNA binding residues [nucleotide binding]
1284663007200	putative dimer interface [polypeptide binding]; other site
1284663007201	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1284663007202	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1284663007203	putative NAD(P) binding site [chemical binding]; other site
1284663007204	SdpI/YhfL protein family; Region: SdpI; pfam13630
1284663007205	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1284663007206	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1284663007207	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1284663007208	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1284663007209	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1284663007210	DNA-binding site [nucleotide binding]; DNA binding site
1284663007211	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1284663007212	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663007213	homodimer interface [polypeptide binding]; other site
1284663007214	aromatic amino acid aminotransferase; Validated; Region: PRK07309
1284663007215	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1284663007216	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663007217	homodimer interface [polypeptide binding]; other site
1284663007218	catalytic residue [active]
1284663007219	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1284663007220	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1284663007221	dimer interface [polypeptide binding]; other site
1284663007222	active site
1284663007223	catalytic residue [active]
1284663007224	hypothetical protein; Provisional; Region: PRK10621
1284663007225	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1284663007226	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663007227	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663007228	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1284663007229	dimerization interface [polypeptide binding]; other site
1284663007230	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1284663007231	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1284663007232	NAD(P) binding site [chemical binding]; other site
1284663007233	putative active site [active]
1284663007234	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1284663007235	Part of AAA domain; Region: AAA_19; pfam13245
1284663007236	Family description; Region: UvrD_C_2; pfam13538
1284663007237	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1284663007238	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1284663007239	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1284663007240	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1284663007241	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1284663007242	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1284663007243	active site
1284663007244	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1284663007245	active site
1284663007246	dimer interface [polypeptide binding]; other site
1284663007247	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1284663007248	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
1284663007249	heterodimer interface [polypeptide binding]; other site
1284663007250	active site
1284663007251	FMN binding site [chemical binding]; other site
1284663007252	homodimer interface [polypeptide binding]; other site
1284663007253	substrate binding site [chemical binding]; other site
1284663007254	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1284663007255	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1284663007256	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1284663007257	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1284663007258	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1284663007259	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1284663007260	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1284663007261	IMP binding site; other site
1284663007262	dimer interface [polypeptide binding]; other site
1284663007263	interdomain contacts; other site
1284663007264	partial ornithine binding site; other site
1284663007265	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1284663007266	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1284663007267	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1284663007268	catalytic site [active]
1284663007269	subunit interface [polypeptide binding]; other site
1284663007270	dihydroorotase; Validated; Region: pyrC; PRK09357
1284663007271	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1284663007272	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1284663007273	active site
1284663007274	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1284663007275	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1284663007276	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1284663007277	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1284663007278	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1284663007279	active site
1284663007280	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1284663007281	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1284663007282	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1284663007283	xanthine permease; Region: pbuX; TIGR03173
1284663007284	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1284663007285	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1284663007286	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1284663007287	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663007288	NAD(P) binding site [chemical binding]; other site
1284663007289	active site
1284663007290	EAL domain; Region: EAL; pfam00563
1284663007291	N-glycosyltransferase; Provisional; Region: PRK11204
1284663007292	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1284663007293	DXD motif; other site
1284663007294	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
1284663007295	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1284663007296	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1284663007297	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1284663007298	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1284663007299	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1284663007300	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1284663007301	purine monophosphate binding site [chemical binding]; other site
1284663007302	dimer interface [polypeptide binding]; other site
1284663007303	putative catalytic residues [active]
1284663007304	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1284663007305	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1284663007306	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1284663007307	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1284663007308	active site
1284663007309	substrate binding site [chemical binding]; other site
1284663007310	cosubstrate binding site; other site
1284663007311	catalytic site [active]
1284663007312	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1284663007313	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1284663007314	dimerization interface [polypeptide binding]; other site
1284663007315	putative ATP binding site [chemical binding]; other site
1284663007316	amidophosphoribosyltransferase; Provisional; Region: PRK07272
1284663007317	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1284663007318	active site
1284663007319	tetramer interface [polypeptide binding]; other site
1284663007320	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1284663007321	active site
1284663007322	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1284663007323	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1284663007324	dimerization interface [polypeptide binding]; other site
1284663007325	ATP binding site [chemical binding]; other site
1284663007326	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1284663007327	dimerization interface [polypeptide binding]; other site
1284663007328	ATP binding site [chemical binding]; other site
1284663007329	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1284663007330	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1284663007331	putative active site [active]
1284663007332	catalytic triad [active]
1284663007333	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
1284663007334	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1284663007335	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1284663007336	ATP binding site [chemical binding]; other site
1284663007337	active site
1284663007338	substrate binding site [chemical binding]; other site
1284663007339	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1284663007340	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1284663007341	NAD binding site [chemical binding]; other site
1284663007342	ATP-grasp domain; Region: ATP-grasp; pfam02222
1284663007343	AIR carboxylase; Region: AIRC; pfam00731
1284663007344	Predicted flavoprotein [General function prediction only]; Region: COG0431
1284663007345	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1284663007346	PAS domain; Region: PAS_10; pfam13596
1284663007347	Predicted flavoprotein [General function prediction only]; Region: COG0431
1284663007348	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1284663007349	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1284663007350	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1284663007351	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1284663007352	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1284663007353	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1284663007354	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
1284663007355	active site
1284663007356	zinc binding site [ion binding]; other site
1284663007357	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1284663007358	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1284663007359	active site
1284663007360	homotetramer interface [polypeptide binding]; other site
1284663007361	homodimer interface [polypeptide binding]; other site
1284663007362	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1284663007363	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1284663007364	Walker A/P-loop; other site
1284663007365	ATP binding site [chemical binding]; other site
1284663007366	Q-loop/lid; other site
1284663007367	ABC transporter signature motif; other site
1284663007368	Walker B; other site
1284663007369	D-loop; other site
1284663007370	H-loop/switch region; other site
1284663007371	FtsX-like permease family; Region: FtsX; pfam02687
1284663007372	Predicted transcriptional regulators [Transcription]; Region: COG1725
1284663007373	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1284663007374	DNA-binding site [nucleotide binding]; DNA binding site
1284663007375	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663007376	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1284663007377	Walker A/P-loop; other site
1284663007378	ATP binding site [chemical binding]; other site
1284663007379	Q-loop/lid; other site
1284663007380	ABC transporter signature motif; other site
1284663007381	Walker B; other site
1284663007382	D-loop; other site
1284663007383	H-loop/switch region; other site
1284663007384	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1284663007385	Ligand Binding Site [chemical binding]; other site
1284663007386	Predicted membrane protein [Function unknown]; Region: COG2246
1284663007387	GtrA-like protein; Region: GtrA; pfam04138
1284663007388	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1284663007389	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1284663007390	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663007391	homodimer interface [polypeptide binding]; other site
1284663007392	catalytic residue [active]
1284663007393	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1284663007394	homodimer interface [polypeptide binding]; other site
1284663007395	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1284663007396	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1284663007397	active site
1284663007398	homodimer interface [polypeptide binding]; other site
1284663007399	catalytic site [active]
1284663007400	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1284663007401	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1284663007402	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663007403	catalytic residue [active]
1284663007404	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1284663007405	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663007406	active site
1284663007407	motif I; other site
1284663007408	motif II; other site
1284663007409	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1284663007410	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1284663007411	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1284663007412	maltose O-acetyltransferase; Provisional; Region: PRK10092
1284663007413	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1284663007414	active site
1284663007415	substrate binding site [chemical binding]; other site
1284663007416	trimer interface [polypeptide binding]; other site
1284663007417	CoA binding site [chemical binding]; other site
1284663007418	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1284663007419	dimer interface [polypeptide binding]; other site
1284663007420	ADP-ribose binding site [chemical binding]; other site
1284663007421	active site
1284663007422	nudix motif; other site
1284663007423	metal binding site [ion binding]; metal-binding site
1284663007424	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1284663007425	nucleotide binding site/active site [active]
1284663007426	HIT family signature motif; other site
1284663007427	catalytic residue [active]
1284663007428	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
1284663007429	classical (c) SDRs; Region: SDR_c; cd05233
1284663007430	NAD(P) binding site [chemical binding]; other site
1284663007431	active site
1284663007432	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
1284663007433	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1284663007434	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1284663007435	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
1284663007436	Sterol carrier protein domain; Region: SCP2_2; pfam13530
1284663007437	H+ Antiporter protein; Region: 2A0121; TIGR00900
1284663007438	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
1284663007439	HTH domain; Region: HTH_11; pfam08279
1284663007440	3H domain; Region: 3H; pfam02829
1284663007441	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1284663007442	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1284663007443	active site
1284663007444	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663007445	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663007446	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1284663007447	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1284663007448	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1284663007449	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
1284663007450	Walker A/P-loop; other site
1284663007451	ATP binding site [chemical binding]; other site
1284663007452	Q-loop/lid; other site
1284663007453	ABC transporter signature motif; other site
1284663007454	Walker B; other site
1284663007455	D-loop; other site
1284663007456	H-loop/switch region; other site
1284663007457	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
1284663007458	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
1284663007459	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1284663007460	catalytic residue [active]
1284663007461	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1284663007462	beta-galactosidase; Region: BGL; TIGR03356
1284663007463	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1284663007464	beta-galactosidase; Region: BGL; TIGR03356
1284663007465	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1284663007466	active site
1284663007467	methionine cluster; other site
1284663007468	phosphorylation site [posttranslational modification]
1284663007469	metal binding site [ion binding]; metal-binding site
1284663007470	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1284663007471	active site
1284663007472	P-loop; other site
1284663007473	phosphorylation site [posttranslational modification]
1284663007474	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1284663007475	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1284663007476	DNA-binding site [nucleotide binding]; DNA binding site
1284663007477	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1284663007478	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1284663007479	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1284663007480	active site
1284663007481	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1284663007482	catalytic core [active]
1284663007483	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1284663007484	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663007485	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1284663007486	active site
1284663007487	motif I; other site
1284663007488	motif II; other site
1284663007489	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1284663007490	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1284663007491	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1284663007492	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1284663007493	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1284663007494	EamA-like transporter family; Region: EamA; cl17759
1284663007495	EamA-like transporter family; Region: EamA; pfam00892
1284663007496	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1284663007497	Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155
1284663007498	putative ligand binding site [chemical binding]; other site
1284663007499	NAD binding site [chemical binding]; other site
1284663007500	catalytic site [active]
1284663007501	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1284663007502	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1284663007503	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1284663007504	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1284663007505	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1284663007506	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
1284663007507	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
1284663007508	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
1284663007509	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1284663007510	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1284663007511	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1284663007512	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1284663007513	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
1284663007514	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
1284663007515	Leucine rich repeat; Region: LRR_8; pfam13855
1284663007516	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1284663007517	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1284663007518	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1284663007519	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1284663007520	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1284663007521	active site
1284663007522	catalytic residue [active]
1284663007523	dimer interface [polypeptide binding]; other site
1284663007524	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1284663007525	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1284663007526	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1284663007527	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1284663007528	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1284663007529	active site
1284663007530	catalytic tetrad [active]
1284663007531	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1284663007532	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1284663007533	active site
1284663007534	catalytic tetrad [active]
1284663007535	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663007536	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663007537	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
1284663007538	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
1284663007539	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1284663007540	active site
1284663007541	HIGH motif; other site
1284663007542	dimer interface [polypeptide binding]; other site
1284663007543	KMSKS motif; other site
1284663007544	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1284663007545	RNA binding surface [nucleotide binding]; other site
1284663007546	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
1284663007547	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1284663007548	active site
1284663007549	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
1284663007550	putative active site [active]
1284663007551	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
1284663007552	Protein of unknown function (DUF554); Region: DUF554; pfam04474
1284663007553	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
1284663007554	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1284663007555	DNA binding residues [nucleotide binding]
1284663007556	drug binding residues [chemical binding]; other site
1284663007557	dimer interface [polypeptide binding]; other site
1284663007558	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1284663007559	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1284663007560	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1284663007561	Protein of unknown function (DUF1440); Region: DUF1440; pfam07274
1284663007562	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1284663007563	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1284663007564	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1284663007565	Walker A/P-loop; other site
1284663007566	ATP binding site [chemical binding]; other site
1284663007567	Q-loop/lid; other site
1284663007568	ABC transporter signature motif; other site
1284663007569	Walker B; other site
1284663007570	D-loop; other site
1284663007571	H-loop/switch region; other site
1284663007572	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1284663007573	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
1284663007574	active site
1284663007575	RibD C-terminal domain; Region: RibD_C; cl17279
1284663007576	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1284663007577	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1284663007578	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1284663007579	Predicted permeases [General function prediction only]; Region: COG0679
1284663007580	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1284663007581	Aspartase; Region: Aspartase; cd01357
1284663007582	active sites [active]
1284663007583	tetramer interface [polypeptide binding]; other site
1284663007584	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663007585	putative substrate translocation pore; other site
1284663007586	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1284663007587	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1284663007588	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
1284663007589	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663007590	putative substrate translocation pore; other site
1284663007591	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663007592	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1284663007593	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1284663007594	Predicted membrane protein [Function unknown]; Region: COG2855
1284663007595	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663007596	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663007597	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1284663007598	dimerization interface [polypeptide binding]; other site
1284663007599	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1284663007600	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1284663007601	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1284663007602	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1284663007603	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1284663007604	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1284663007605	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1284663007606	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1284663007607	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1284663007608	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1284663007609	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1284663007610	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1284663007611	DNA binding site [nucleotide binding]
1284663007612	active site
1284663007613	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1284663007614	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663007615	Walker A/P-loop; other site
1284663007616	ATP binding site [chemical binding]; other site
1284663007617	Q-loop/lid; other site
1284663007618	ABC transporter signature motif; other site
1284663007619	Walker B; other site
1284663007620	D-loop; other site
1284663007621	H-loop/switch region; other site
1284663007622	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1284663007623	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1284663007624	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1284663007625	classical (c) SDRs; Region: SDR_c; cd05233
1284663007626	NAD(P) binding site [chemical binding]; other site
1284663007627	active site
1284663007628	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1284663007629	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1284663007630	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1284663007631	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1284663007632	DNA binding residues [nucleotide binding]
1284663007633	putative dimer interface [polypeptide binding]; other site
1284663007634	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
1284663007635	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
1284663007636	metal binding site [ion binding]; metal-binding site
1284663007637	dimer interface [polypeptide binding]; other site
1284663007638	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1284663007639	FtsX-like permease family; Region: FtsX; pfam02687
1284663007640	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1284663007641	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1284663007642	FtsX-like permease family; Region: FtsX; pfam02687
1284663007643	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1284663007644	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1284663007645	Walker A/P-loop; other site
1284663007646	ATP binding site [chemical binding]; other site
1284663007647	Q-loop/lid; other site
1284663007648	ABC transporter signature motif; other site
1284663007649	Walker B; other site
1284663007650	D-loop; other site
1284663007651	H-loop/switch region; other site
1284663007652	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1284663007653	endonuclease III; Region: ENDO3c; smart00478
1284663007654	minor groove reading motif; other site
1284663007655	helix-hairpin-helix signature motif; other site
1284663007656	substrate binding pocket [chemical binding]; other site
1284663007657	active site
1284663007658	maltose O-acetyltransferase; Provisional; Region: PRK10092
1284663007659	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1284663007660	active site
1284663007661	substrate binding site [chemical binding]; other site
1284663007662	trimer interface [polypeptide binding]; other site
1284663007663	CoA binding site [chemical binding]; other site
1284663007664	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1284663007665	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
1284663007666	Catalytic site [active]
1284663007667	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1284663007668	PYR/PP interface [polypeptide binding]; other site
1284663007669	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1284663007670	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663007671	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1284663007672	Coenzyme A binding pocket [chemical binding]; other site
1284663007673	potential frameshift: common BLAST hit: pgm8
1284663007674	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1284663007675	catalytic core [active]
1284663007676	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663007677	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663007678	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1284663007679	dimerization interface [polypeptide binding]; other site
1284663007680	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663007681	NAD(P) binding site [chemical binding]; other site
1284663007682	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1284663007683	active site
1284663007684	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
1284663007685	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1284663007686	catalytic Zn binding site [ion binding]; other site
1284663007687	NAD(P) binding site [chemical binding]; other site
1284663007688	structural Zn binding site [ion binding]; other site
1284663007689	short chain dehydrogenase; Provisional; Region: PRK06940
1284663007690	classical (c) SDRs; Region: SDR_c; cd05233
1284663007691	NAD(P) binding site [chemical binding]; other site
1284663007692	active site
1284663007693	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
1284663007694	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1284663007695	Ligand Binding Site [chemical binding]; other site
1284663007696	maltose O-acetyltransferase; Provisional; Region: PRK10092
1284663007697	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1284663007698	active site
1284663007699	substrate binding site [chemical binding]; other site
1284663007700	trimer interface [polypeptide binding]; other site
1284663007701	CoA binding site [chemical binding]; other site
1284663007702	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1284663007703	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663007704	motif II; other site
1284663007705	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1284663007706	Helix-turn-helix domain; Region: HTH_38; pfam13936
1284663007707	Integrase core domain; Region: rve; pfam00665
1284663007708	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1284663007709	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1284663007710	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1284663007711	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1284663007712	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663007713	homodimer interface [polypeptide binding]; other site
1284663007714	catalytic residue [active]
1284663007715	Protein of unknown function (DUF3737); Region: DUF3737; pfam12541
1284663007716	potential frameshift: common BLAST hit: Aldo/keto reductase family protein
1284663007717	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
1284663007718	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1284663007719	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1284663007720	catalytic tetrad [active]
1284663007721	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1284663007722	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1284663007723	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1284663007724	Walker A/P-loop; other site
1284663007725	ATP binding site [chemical binding]; other site
1284663007726	Q-loop/lid; other site
1284663007727	ABC transporter signature motif; other site
1284663007728	Walker B; other site
1284663007729	D-loop; other site
1284663007730	H-loop/switch region; other site
1284663007731	potential frameshift: common BLAST hit: ABC transporter, ATP-binding and permease protein
1284663007732	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663007733	Walker B; other site
1284663007734	D-loop; other site
1284663007735	H-loop/switch region; other site
1284663007736	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1284663007737	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663007738	Walker A/P-loop; other site
1284663007739	ATP binding site [chemical binding]; other site
1284663007740	Q-loop/lid; other site
1284663007741	potential frameshift: common BLAST hit: Transport protein
1284663007742	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663007743	putative substrate translocation pore; other site
1284663007744	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1284663007745	Predicted membrane protein [Function unknown]; Region: COG1511
1284663007746	Predicted membrane protein [Function unknown]; Region: COG1511
1284663007747	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1284663007748	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1284663007749	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663007750	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663007751	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1284663007752	dimerization interface [polypeptide binding]; other site
1284663007753	putative DNA binding site [nucleotide binding]; other site
1284663007754	putative Zn2+ binding site [ion binding]; other site
1284663007755	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1284663007756	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
1284663007757	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1284663007758	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1284663007759	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1284663007760	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1284663007761	serine/threonine protein kinase; Provisional; Region: PRK14879
1284663007762	CAAX protease self-immunity; Region: Abi; pfam02517
1284663007763	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1284663007764	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1284663007765	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1284663007766	ABC transporter; Region: ABC_tran_2; pfam12848
1284663007767	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1284663007768	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663007769	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1284663007770	active site
1284663007771	motif I; other site
1284663007772	motif II; other site
1284663007773	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663007774	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
1284663007775	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663007776	Walker A/P-loop; other site
1284663007777	ATP binding site [chemical binding]; other site
1284663007778	Q-loop/lid; other site
1284663007779	Putative zinc-finger of transcription factor IIIC complex; Region: zf-TFIIIC; pfam12660
1284663007780	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
1284663007781	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663007782	ABC transporter signature motif; other site
1284663007783	Walker B; other site
1284663007784	D-loop; other site
1284663007785	H-loop/switch region; other site
1284663007786	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663007787	Walker A/P-loop; other site
1284663007788	ATP binding site [chemical binding]; other site
1284663007789	Q-loop/lid; other site
1284663007790	ABC transporter signature motif; other site
1284663007791	Walker B; other site
1284663007792	D-loop; other site
1284663007793	H-loop/switch region; other site
1284663007794	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1284663007795	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663007796	non-specific DNA binding site [nucleotide binding]; other site
1284663007797	salt bridge; other site
1284663007798	sequence-specific DNA binding site [nucleotide binding]; other site
1284663007799	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
1284663007800	Uncharacterized conserved protein [Function unknown]; Region: COG3379
1284663007801	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
1284663007802	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1284663007803	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
1284663007804	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1284663007805	DNA-binding site [nucleotide binding]; DNA binding site
1284663007806	UTRA domain; Region: UTRA; pfam07702
1284663007807	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1284663007808	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
1284663007809	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041
1284663007810	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
1284663007811	HPr interaction site; other site
1284663007812	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1284663007813	active site
1284663007814	phosphorylation site [posttranslational modification]
1284663007815	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1284663007816	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1284663007817	metal binding site [ion binding]; metal-binding site
1284663007818	active site
1284663007819	I-site; other site
1284663007820	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1284663007821	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
1284663007822	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
1284663007823	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
1284663007824	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1284663007825	effector binding site; other site
1284663007826	active site
1284663007827	Zn binding site [ion binding]; other site
1284663007828	glycine loop; other site
1284663007829	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1284663007830	active site
1284663007831	catalytic residues [active]
1284663007832	metal binding site [ion binding]; metal-binding site
1284663007833	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1284663007834	ApbE family; Region: ApbE; pfam02424
1284663007835	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1284663007836	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1284663007837	FMN binding site [chemical binding]; other site
1284663007838	active site
1284663007839	catalytic residues [active]
1284663007840	substrate binding site [chemical binding]; other site
1284663007841	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663007842	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663007843	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1284663007844	dimerization interface [polypeptide binding]; other site
1284663007845	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1284663007846	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1284663007847	transmembrane helices; other site
1284663007848	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
1284663007849	Predicted membrane protein [Function unknown]; Region: COG4640
1284663007850	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1284663007851	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
1284663007852	Double zinc ribbon; Region: DZR; pfam12773
1284663007853	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1284663007854	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1284663007855	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1284663007856	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1284663007857	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1284663007858	Collagen binding domain; Region: Collagen_bind; pfam05737
1284663007859	EamA-like transporter family; Region: EamA; pfam00892
1284663007860	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1284663007861	EamA-like transporter family; Region: EamA; pfam00892
1284663007862	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1284663007863	catalytic triad [active]
1284663007864	catalytic triad [active]
1284663007865	oxyanion hole [active]
1284663007866	Amidohydrolase; Region: Amidohydro_2; pfam04909
1284663007867	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663007868	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1284663007869	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1284663007870	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1284663007871	nucleotide binding site [chemical binding]; other site
1284663007872	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
1284663007873	active site
1284663007874	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1284663007875	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1284663007876	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663007877	Walker A/P-loop; other site
1284663007878	ATP binding site [chemical binding]; other site
1284663007879	Q-loop/lid; other site
1284663007880	ABC transporter signature motif; other site
1284663007881	Walker B; other site
1284663007882	D-loop; other site
1284663007883	H-loop/switch region; other site
1284663007884	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1284663007885	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1284663007886	putative Zn2+ binding site [ion binding]; other site
1284663007887	putative DNA binding site [nucleotide binding]; other site
1284663007888	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1284663007889	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1284663007890	DNA binding site [nucleotide binding]
1284663007891	domain linker motif; other site
1284663007892	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1284663007893	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1284663007894	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663007895	active site
1284663007896	motif I; other site
1284663007897	motif II; other site
1284663007898	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1284663007899	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1284663007900	dimer interface [polypeptide binding]; other site
1284663007901	FMN binding site [chemical binding]; other site
1284663007902	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1284663007903	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1284663007904	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1284663007905	active site turn [active]
1284663007906	phosphorylation site [posttranslational modification]
1284663007907	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1284663007908	HPr interaction site; other site
1284663007909	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1284663007910	active site
1284663007911	phosphorylation site [posttranslational modification]
1284663007912	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
1284663007913	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663007914	Walker A/P-loop; other site
1284663007915	ATP binding site [chemical binding]; other site
1284663007916	Q-loop/lid; other site
1284663007917	ABC transporter signature motif; other site
1284663007918	Walker B; other site
1284663007919	D-loop; other site
1284663007920	H-loop/switch region; other site
1284663007921	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1284663007922	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1284663007923	TM-ABC transporter signature motif; other site
1284663007924	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1284663007925	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1284663007926	zinc binding site [ion binding]; other site
1284663007927	putative ligand binding site [chemical binding]; other site
1284663007928	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1284663007929	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1284663007930	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1284663007931	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1284663007932	FOG: CBS domain [General function prediction only]; Region: COG0517
1284663007933	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1284663007934	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1284663007935	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1284663007936	Walker A/P-loop; other site
1284663007937	ATP binding site [chemical binding]; other site
1284663007938	Q-loop/lid; other site
1284663007939	ABC transporter signature motif; other site
1284663007940	Walker B; other site
1284663007941	D-loop; other site
1284663007942	H-loop/switch region; other site
1284663007943	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1284663007944	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1284663007945	Walker A/P-loop; other site
1284663007946	ATP binding site [chemical binding]; other site
1284663007947	Q-loop/lid; other site
1284663007948	ABC transporter signature motif; other site
1284663007949	Walker B; other site
1284663007950	D-loop; other site
1284663007951	H-loop/switch region; other site
1284663007952	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1284663007953	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1284663007954	TM-ABC transporter signature motif; other site
1284663007955	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1284663007956	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1284663007957	TM-ABC transporter signature motif; other site
1284663007958	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1284663007959	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
1284663007960	putative ligand binding site [chemical binding]; other site
1284663007961	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
1284663007962	active site
1284663007963	Predicted membrane protein [Function unknown]; Region: COG2246
1284663007964	GtrA-like protein; Region: GtrA; pfam04138
1284663007965	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1284663007966	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663007967	non-specific DNA binding site [nucleotide binding]; other site
1284663007968	salt bridge; other site
1284663007969	sequence-specific DNA binding site [nucleotide binding]; other site
1284663007970	manganese transport protein MntH; Reviewed; Region: PRK00701
1284663007971	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1284663007972	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1284663007973	Ligand Binding Site [chemical binding]; other site
1284663007974	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1284663007975	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1284663007976	dimerization interface [polypeptide binding]; other site
1284663007977	putative DNA binding site [nucleotide binding]; other site
1284663007978	putative Zn2+ binding site [ion binding]; other site
1284663007979	Cadmium resistance transporter; Region: Cad; pfam03596
1284663007980	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1284663007981	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1284663007982	Walker A/P-loop; other site
1284663007983	ATP binding site [chemical binding]; other site
1284663007984	Q-loop/lid; other site
1284663007985	ABC transporter signature motif; other site
1284663007986	Walker B; other site
1284663007987	D-loop; other site
1284663007988	H-loop/switch region; other site
1284663007989	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1284663007990	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1284663007991	FtsX-like permease family; Region: FtsX; pfam02687
1284663007992	potential frameshift: common BLAST hit: Cell surface protein, LPXTG-motif cell wall anchor
1284663007993	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1284663007994	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1284663007995	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1284663007996	dockerin binding interface; other site
1284663007997	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1284663007998	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1284663007999	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1284663008000	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
1284663008001	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1284663008002	active site
1284663008003	metal binding site [ion binding]; metal-binding site
1284663008004	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1284663008005	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663008006	non-specific DNA binding site [nucleotide binding]; other site
1284663008007	salt bridge; other site
1284663008008	sequence-specific DNA binding site [nucleotide binding]; other site
1284663008009	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
1284663008010	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1284663008011	HPr interaction site; other site
1284663008012	active site
1284663008013	phosphorylation site [posttranslational modification]
1284663008014	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1284663008015	active site
1284663008016	P-loop; other site
1284663008017	phosphorylation site [posttranslational modification]
1284663008018	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1284663008019	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1284663008020	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1284663008021	beta-galactosidase; Region: BGL; TIGR03356
1284663008022	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
1284663008023	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1284663008024	NADP binding site [chemical binding]; other site
1284663008025	putative substrate binding site [chemical binding]; other site
1284663008026	active site
1284663008027	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1284663008028	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1284663008029	DNA binding residues [nucleotide binding]
1284663008030	putative dimer interface [polypeptide binding]; other site
1284663008031	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1284663008032	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1284663008033	catalytic residue [active]
1284663008034	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1284663008035	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1284663008036	SdpI/YhfL protein family; Region: SdpI; pfam13630
1284663008037	ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555
1284663008038	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
1284663008039	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1284663008040	metal binding site [ion binding]; metal-binding site
1284663008041	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1284663008042	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1284663008043	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1284663008044	metal binding site [ion binding]; metal-binding site
1284663008045	active site
1284663008046	I-site; other site
1284663008047	DNA polymerase IV; Reviewed; Region: PRK03103
1284663008048	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1284663008049	active site
1284663008050	DNA binding site [nucleotide binding]
1284663008051	DNA polymerase IV; Reviewed; Region: PRK03103
1284663008052	potential frameshift: common BLAST hit: ImpB/MucB/SamB family protein
1284663008053	Y-family of DNA polymerases; Region: PolY; cl12025
1284663008054	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1284663008055	Y-family of DNA polymerases; Region: PolY; cl12025
1284663008056	active site
1284663008057	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1284663008058	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1284663008059	DNA binding residues [nucleotide binding]
1284663008060	putative dimer interface [polypeptide binding]; other site
1284663008061	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1284663008062	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1284663008063	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1284663008064	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1284663008065	active site
1284663008066	catalytic tetrad [active]
1284663008067	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663008068	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1284663008069	NAD(P) binding site [chemical binding]; other site
1284663008070	active site
1284663008071	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1284663008072	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1284663008073	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1284663008074	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1284663008075	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1284663008076	short chain dehydrogenase; Provisional; Region: PRK07774
1284663008077	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
1284663008078	NADP binding site [chemical binding]; other site
1284663008079	substrate binding site [chemical binding]; other site
1284663008080	active site
1284663008081	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1284663008082	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1284663008083	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663008084	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663008085	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663008086	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663008087	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1284663008088	classical (c) SDRs; Region: SDR_c; cd05233
1284663008089	NAD(P) binding site [chemical binding]; other site
1284663008090	active site
1284663008091	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1284663008092	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1284663008093	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1284663008094	atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267
1284663008095	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1284663008096	putative NAD(P) binding site [chemical binding]; other site
1284663008097	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1284663008098	substrate binding site [chemical binding]; other site
1284663008099	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1284663008100	Cyclophilin-like; Region: Cyclophil_like; cl17583
1284663008101	short chain dehydrogenase; Provisional; Region: PRK06172
1284663008102	classical (c) SDRs; Region: SDR_c; cd05233
1284663008103	NAD(P) binding site [chemical binding]; other site
1284663008104	active site
1284663008105	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663008106	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1284663008107	NAD(P) binding site [chemical binding]; other site
1284663008108	active site
1284663008109	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1284663008110	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1284663008111	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1284663008112	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663008113	Walker A/P-loop; other site
1284663008114	ATP binding site [chemical binding]; other site
1284663008115	Q-loop/lid; other site
1284663008116	ABC transporter signature motif; other site
1284663008117	Walker B; other site
1284663008118	D-loop; other site
1284663008119	H-loop/switch region; other site
1284663008120	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1284663008121	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1284663008122	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663008123	Walker A/P-loop; other site
1284663008124	ATP binding site [chemical binding]; other site
1284663008125	Q-loop/lid; other site
1284663008126	ABC transporter signature motif; other site
1284663008127	Walker B; other site
1284663008128	D-loop; other site
1284663008129	H-loop/switch region; other site
1284663008130	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1284663008131	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1284663008132	metal binding site [ion binding]; metal-binding site
1284663008133	dimer interface [polypeptide binding]; other site
1284663008134	oxidoreductase; Provisional; Region: PRK06128
1284663008135	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663008136	NAD(P) binding site [chemical binding]; other site
1284663008137	active site
1284663008138	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
1284663008139	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1284663008140	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663008141	non-specific DNA binding site [nucleotide binding]; other site
1284663008142	salt bridge; other site
1284663008143	sequence-specific DNA binding site [nucleotide binding]; other site
1284663008144	inner membrane transporter YjeM; Provisional; Region: PRK15238
1284663008145	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
1284663008146	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1284663008147	dimer interface [polypeptide binding]; other site
1284663008148	active site
1284663008149	metal binding site [ion binding]; metal-binding site
1284663008150	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1284663008151	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
1284663008152	catalytic Zn binding site [ion binding]; other site
1284663008153	NAD binding site [chemical binding]; other site
1284663008154	structural Zn binding site [ion binding]; other site
1284663008155	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1284663008156	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1284663008157	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1284663008158	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
1284663008159	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
1284663008160	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
1284663008161	MucBP domain; Region: MucBP; pfam06458
1284663008162	Helix-turn-helix domain; Region: HTH_18; pfam12833
1284663008163	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1284663008164	TfoX C-terminal domain; Region: TfoX_C; pfam04994
1284663008165	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1284663008166	ATP binding site [chemical binding]; other site
1284663008167	Mg2+ binding site [ion binding]; other site
1284663008168	G-X-G motif; other site
1284663008169	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1284663008170	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1284663008171	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1284663008172	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1284663008173	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1284663008174	Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
1284663008175	NAD(P) binding site [chemical binding]; other site
1284663008176	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1284663008177	potential frameshift: common BLAST hit: Cell surface protein, CscA/DUF916 family
1284663008178	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1284663008179	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1284663008180	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1284663008181	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1284663008182	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
1284663008183	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
1284663008184	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
1284663008185	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
1284663008186	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
1284663008187	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
1284663008188	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
1284663008189	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
1284663008190	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
1284663008191	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
1284663008192	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663008193	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1284663008194	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663008195	motif II; other site
1284663008196	Predicted transcriptional regulators [Transcription]; Region: COG1733
1284663008197	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1284663008198	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1284663008199	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663008200	putative substrate translocation pore; other site
1284663008201	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1284663008202	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1284663008203	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
1284663008204	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
1284663008205	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1284663008206	Ligand Binding Site [chemical binding]; other site
1284663008207	Molecular Tunnel; other site
1284663008208	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1284663008209	Helix-turn-helix domain; Region: HTH_38; pfam13936
1284663008210	Integrase core domain; Region: rve; pfam00665
1284663008211	potential frameshift: common BLAST hit: Asparagine synthetase
1284663008212	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
1284663008213	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
1284663008214	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1284663008215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1284663008216	active site
1284663008217	phosphorylation site [posttranslational modification]
1284663008218	intermolecular recognition site; other site
1284663008219	dimerization interface [polypeptide binding]; other site
1284663008220	LytTr DNA-binding domain; Region: LytTR; pfam04397
1284663008221	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663008222	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663008223	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663008224	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1284663008225	NAD(P) binding site [chemical binding]; other site
1284663008226	active site
1284663008227	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1284663008228	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1284663008229	NAD(P) binding site [chemical binding]; other site
1284663008230	catalytic residues [active]
1284663008231	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1284663008232	AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522
1284663008233	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1284663008234	active site
1284663008235	Bacterial SH3 domain; Region: SH3_5; pfam08460
1284663008236	Bacterial SH3 domain; Region: SH3_5; pfam08460
1284663008237	Bacterial SH3 domain; Region: SH3_5; pfam08460
1284663008238	Bacterial SH3 domain; Region: SH3_5; pfam08460
1284663008239	Bacterial SH3 domain; Region: SH3_5; pfam08460
1284663008240	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
1284663008241	Predicted transcriptional regulators [Transcription]; Region: COG1733
1284663008242	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1284663008243	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1284663008244	classical (c) SDRs; Region: SDR_c; cd05233
1284663008245	NAD(P) binding site [chemical binding]; other site
1284663008246	active site
1284663008247	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663008248	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663008249	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
1284663008250	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1284663008251	NADP binding site [chemical binding]; other site
1284663008252	putative substrate binding site [chemical binding]; other site
1284663008253	active site
1284663008254	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
1284663008255	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1284663008256	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1284663008257	active site
1284663008258	catalytic tetrad [active]
1284663008259	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663008260	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663008261	putative substrate translocation pore; other site
1284663008262	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663008263	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663008264	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663008265	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1284663008266	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1284663008267	intersubunit interface [polypeptide binding]; other site
1284663008268	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1284663008269	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1284663008270	Walker A/P-loop; other site
1284663008271	ATP binding site [chemical binding]; other site
1284663008272	Q-loop/lid; other site
1284663008273	ABC transporter signature motif; other site
1284663008274	Walker B; other site
1284663008275	D-loop; other site
1284663008276	H-loop/switch region; other site
1284663008277	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1284663008278	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1284663008279	ABC-ATPase subunit  interface; other site
1284663008280	dimer interface [polypeptide binding]; other site
1284663008281	putative PBP binding regions; other site
1284663008282	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1284663008283	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1284663008284	ABC-ATPase subunit  interface; other site
1284663008285	dimer interface [polypeptide binding]; other site
1284663008286	putative PBP binding regions; other site
1284663008287	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663008288	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
1284663008289	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1284663008290	putative NAD(P) binding site [chemical binding]; other site
1284663008291	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1284663008292	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663008293	NAD(P) binding site [chemical binding]; other site
1284663008294	active site
1284663008295	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1284663008296	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1284663008297	putative trimer interface [polypeptide binding]; other site
1284663008298	putative CoA binding site [chemical binding]; other site
1284663008299	potential frameshift: common BLAST hit: Short-chain dehydrogenase/oxidoreductase
1284663008300	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663008301	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1284663008302	active site
1284663008303	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1284663008304	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1284663008305	DNA binding residues [nucleotide binding]
1284663008306	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1284663008307	MucBP domain; Region: MucBP; pfam06458
1284663008308	MucBP domain; Region: MucBP; pfam06458
1284663008309	MucBP domain; Region: MucBP; pfam06458
1284663008310	MucBP domain; Region: MucBP; pfam06458
1284663008311	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1284663008312	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1284663008313	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1284663008314	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663008315	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1284663008316	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1284663008317	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1284663008318	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
1284663008319	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
1284663008320	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
1284663008321	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
1284663008322	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
1284663008323	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
1284663008324	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
1284663008325	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
1284663008326	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
1284663008327	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1284663008328	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1284663008329	GTP-binding protein LepA; Provisional; Region: PRK05433
1284663008330	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1284663008331	G1 box; other site
1284663008332	putative GEF interaction site [polypeptide binding]; other site
1284663008333	GTP/Mg2+ binding site [chemical binding]; other site
1284663008334	Switch I region; other site
1284663008335	G2 box; other site
1284663008336	G3 box; other site
1284663008337	Switch II region; other site
1284663008338	G4 box; other site
1284663008339	G5 box; other site
1284663008340	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1284663008341	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1284663008342	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1284663008343	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1284663008344	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1284663008345	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1284663008346	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1284663008347	putative NADH binding site [chemical binding]; other site
1284663008348	putative active site [active]
1284663008349	nudix motif; other site
1284663008350	putative metal binding site [ion binding]; other site
1284663008351	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663008352	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663008353	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1284663008354	dimerization interface [polypeptide binding]; other site
1284663008355	hypothetical protein; Validated; Region: PRK07121
1284663008356	Predicted oxidoreductase [General function prediction only]; Region: COG3573
1284663008357	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
1284663008358	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1284663008359	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1284663008360	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663008361	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663008362	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663008363	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663008364	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1284663008365	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1284663008366	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1284663008367	dimerization interface [polypeptide binding]; other site
1284663008368	DPS ferroxidase diiron center [ion binding]; other site
1284663008369	ion pore; other site
1284663008370	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1284663008371	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1284663008372	DNA-binding site [nucleotide binding]; DNA binding site
1284663008373	UTRA domain; Region: UTRA; pfam07702
1284663008374	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1284663008375	beta-galactosidase; Region: BGL; TIGR03356
1284663008376	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1284663008377	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1284663008378	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1284663008379	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1284663008380	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1284663008381	DNA binding residues [nucleotide binding]
1284663008382	putative dimer interface [polypeptide binding]; other site
1284663008383	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1284663008384	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1284663008385	Double zinc ribbon; Region: DZR; pfam12773
1284663008386	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1284663008387	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1284663008388	Protein of unknown function (DUF3781); Region: DUF3781; pfam12636
1284663008389	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
1284663008390	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1284663008391	conserved cys residue [active]
1284663008392	Predicted transcriptional regulators [Transcription]; Region: COG1733
1284663008393	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1284663008394	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1284663008395	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1284663008396	Walker A/P-loop; other site
1284663008397	ATP binding site [chemical binding]; other site
1284663008398	Q-loop/lid; other site
1284663008399	ABC transporter signature motif; other site
1284663008400	Walker B; other site
1284663008401	D-loop; other site
1284663008402	H-loop/switch region; other site
1284663008403	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1284663008404	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663008405	non-specific DNA binding site [nucleotide binding]; other site
1284663008406	salt bridge; other site
1284663008407	sequence-specific DNA binding site [nucleotide binding]; other site
1284663008408	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
1284663008409	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1284663008410	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663008411	non-specific DNA binding site [nucleotide binding]; other site
1284663008412	salt bridge; other site
1284663008413	sequence-specific DNA binding site [nucleotide binding]; other site
1284663008414	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1284663008415	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1284663008416	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1284663008417	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1284663008418	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663008419	Walker A/P-loop; other site
1284663008420	ATP binding site [chemical binding]; other site
1284663008421	Q-loop/lid; other site
1284663008422	ABC transporter signature motif; other site
1284663008423	Walker B; other site
1284663008424	D-loop; other site
1284663008425	H-loop/switch region; other site
1284663008426	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1284663008427	catalytic core [active]
1284663008428	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1284663008429	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1284663008430	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1284663008431	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1284663008432	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1284663008433	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1284663008434	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1284663008435	S-adenosylmethionine binding site [chemical binding]; other site
1284663008436	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1284663008437	active site
1284663008438	ATP binding site [chemical binding]; other site
1284663008439	substrate binding site [chemical binding]; other site
1284663008440	activation loop (A-loop); other site
1284663008441	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1284663008442	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1284663008443	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1284663008444	Helix-turn-helix domain; Region: HTH_38; pfam13936
1284663008445	Integrase core domain; Region: rve; pfam00665
1284663008446	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
1284663008447	AzlC protein; Region: AzlC; pfam03591
1284663008448	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1284663008449	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1284663008450	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1284663008451	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1284663008452	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
1284663008453	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1284663008454	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1284663008455	dimer interface [polypeptide binding]; other site
1284663008456	phosphorylation site [posttranslational modification]
1284663008457	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1284663008458	ATP binding site [chemical binding]; other site
1284663008459	Mg2+ binding site [ion binding]; other site
1284663008460	G-X-G motif; other site
1284663008461	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1284663008462	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1284663008463	active site
1284663008464	phosphorylation site [posttranslational modification]
1284663008465	intermolecular recognition site; other site
1284663008466	dimerization interface [polypeptide binding]; other site
1284663008467	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1284663008468	DNA binding site [nucleotide binding]
1284663008469	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1284663008470	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
1284663008471	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
1284663008472	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843
1284663008473	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1284663008474	active site
1284663008475	Protein of unknown function (DUF1129); Region: DUF1129; pfam06570
1284663008476	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1284663008477	GTP-binding protein YchF; Reviewed; Region: PRK09601
1284663008478	YchF GTPase; Region: YchF; cd01900
1284663008479	G1 box; other site
1284663008480	GTP/Mg2+ binding site [chemical binding]; other site
1284663008481	Switch I region; other site
1284663008482	G2 box; other site
1284663008483	Switch II region; other site
1284663008484	G3 box; other site
1284663008485	G4 box; other site
1284663008486	G5 box; other site
1284663008487	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1284663008488	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
1284663008489	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1284663008490	ParB-like nuclease domain; Region: ParB; smart00470
1284663008491	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
1284663008492	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1284663008493	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1284663008494	P-loop; other site
1284663008495	Magnesium ion binding site [ion binding]; other site
1284663008496	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1284663008497	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1284663008498	ParB-like nuclease domain; Region: ParBc; pfam02195
1284663008499	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1284663008500	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1284663008501	S-adenosylmethionine binding site [chemical binding]; other site
1284663008502	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1284663008503	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1284663008504	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1284663008505	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
1284663008506	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1284663008507	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1284663008508	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1284663008509	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1284663008510	dimerization interface [polypeptide binding]; other site
1284663008511	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1284663008512	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1284663008513	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1284663008514	homodimer interface [polypeptide binding]; other site
1284663008515	catalytic residue [active]
1284663008516	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1284663008517	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1284663008518	substrate binding pocket [chemical binding]; other site
1284663008519	membrane-bound complex binding site; other site
1284663008520	hinge residues; other site
1284663008521	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1284663008522	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663008523	dimer interface [polypeptide binding]; other site
1284663008524	conserved gate region; other site
1284663008525	putative PBP binding loops; other site
1284663008526	ABC-ATPase subunit interface; other site
1284663008527	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1284663008528	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1284663008529	Walker A/P-loop; other site
1284663008530	ATP binding site [chemical binding]; other site
1284663008531	Q-loop/lid; other site
1284663008532	ABC transporter signature motif; other site
1284663008533	Walker B; other site
1284663008534	D-loop; other site
1284663008535	H-loop/switch region; other site
1284663008536	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1284663008537	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1284663008538	substrate binding pocket [chemical binding]; other site
1284663008539	membrane-bound complex binding site; other site
1284663008540	hinge residues; other site
1284663008541	Predicted transcriptional regulators [Transcription]; Region: COG1695
1284663008542	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1284663008543	Predicted membrane protein [Function unknown]; Region: COG4709
1284663008544	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
1284663008545	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1284663008546	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1284663008547	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1284663008548	active site turn [active]
1284663008549	phosphorylation site [posttranslational modification]
1284663008550	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1284663008551	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1284663008552	HPr interaction site; other site
1284663008553	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1284663008554	active site
1284663008555	phosphorylation site [posttranslational modification]
1284663008556	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1284663008557	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1284663008558	Ca binding site [ion binding]; other site
1284663008559	active site
1284663008560	catalytic site [active]
1284663008561	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1284663008562	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1284663008563	DNA binding site [nucleotide binding]
1284663008564	domain linker motif; other site
1284663008565	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1284663008566	putative dimerization interface [polypeptide binding]; other site
1284663008567	putative ligand binding site [chemical binding]; other site
1284663008568	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1284663008569	putative active site [active]
1284663008570	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1284663008571	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
1284663008572	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1284663008573	Walker A/P-loop; other site
1284663008574	ATP binding site [chemical binding]; other site
1284663008575	Q-loop/lid; other site
1284663008576	ABC transporter signature motif; other site
1284663008577	Walker B; other site
1284663008578	D-loop; other site
1284663008579	H-loop/switch region; other site
1284663008580	TRAM domain; Region: TRAM; cl01282
1284663008581	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1284663008582	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1284663008583	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1284663008584	NADP binding site [chemical binding]; other site
1284663008585	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663008586	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1284663008587	active site
1284663008588	motif I; other site
1284663008589	motif II; other site
1284663008590	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1284663008591	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1284663008592	ROK family; Region: ROK; pfam00480
1284663008593	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
1284663008594	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
1284663008595	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
1284663008596	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1284663008597	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1284663008598	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1284663008599	active site
1284663008600	P-loop; other site
1284663008601	phosphorylation site [posttranslational modification]
1284663008602	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1284663008603	active site
1284663008604	phosphorylation site [posttranslational modification]
1284663008605	PRD domain; Region: PRD; pfam00874
1284663008606	PRD domain; Region: PRD; pfam00874
1284663008607	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1284663008608	active site
1284663008609	P-loop; other site
1284663008610	phosphorylation site [posttranslational modification]
1284663008611	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1284663008612	active site
1284663008613	phosphorylation site [posttranslational modification]
1284663008614	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1284663008615	DNA binding residues [nucleotide binding]
1284663008616	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1284663008617	putative dimer interface [polypeptide binding]; other site
1284663008618	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1284663008619	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1284663008620	NADP binding site [chemical binding]; other site
1284663008621	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1284663008622	HPr interaction site; other site
1284663008623	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1284663008624	active site
1284663008625	phosphorylation site [posttranslational modification]
1284663008626	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1284663008627	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1284663008628	active site turn [active]
1284663008629	phosphorylation site [posttranslational modification]
1284663008630	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1284663008631	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1284663008632	endonuclease III; Region: ENDO3c; smart00478
1284663008633	minor groove reading motif; other site
1284663008634	helix-hairpin-helix signature motif; other site
1284663008635	substrate binding pocket [chemical binding]; other site
1284663008636	active site
1284663008637	potential frameshift: common BLAST hit: NADPH-dependent FMN reductase family protein
1284663008638	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1284663008639	Predicted flavoprotein [General function prediction only]; Region: COG0431
1284663008640	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
1284663008641	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1284663008642	metal binding site 2 [ion binding]; metal-binding site
1284663008643	putative DNA binding helix; other site
1284663008644	metal binding site 1 [ion binding]; metal-binding site
1284663008645	dimer interface [polypeptide binding]; other site
1284663008646	structural Zn2+ binding site [ion binding]; other site
1284663008647	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1284663008648	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1284663008649	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1284663008650	active site
1284663008651	metal binding site [ion binding]; metal-binding site
1284663008652	hexamer interface [polypeptide binding]; other site
1284663008653	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1284663008654	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1284663008655	Coenzyme A binding pocket [chemical binding]; other site
1284663008656	LrgA family; Region: LrgA; pfam03788
1284663008657	LrgB-like family; Region: LrgB; pfam04172
1284663008658	EDD domain protein, DegV family; Region: DegV; TIGR00762
1284663008659	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1284663008660	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
1284663008661	phytoene desaturase; Region: crtI_fam; TIGR02734
1284663008662	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1284663008663	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1284663008664	active site lid residues [active]
1284663008665	substrate binding pocket [chemical binding]; other site
1284663008666	catalytic residues [active]
1284663008667	substrate-Mg2+ binding site; other site
1284663008668	aspartate-rich region 1; other site
1284663008669	aspartate-rich region 2; other site
1284663008670	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1284663008671	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1284663008672	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1284663008673	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1284663008674	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1284663008675	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1284663008676	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1284663008677	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1284663008678	adenylosuccinate lyase; Provisional; Region: PRK07492
1284663008679	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1284663008680	tetramer interface [polypeptide binding]; other site
1284663008681	active site
1284663008682	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1284663008683	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1284663008684	GDP-binding site [chemical binding]; other site
1284663008685	ACT binding site; other site
1284663008686	IMP binding site; other site
1284663008687	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1284663008688	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1284663008689	active site
1284663008690	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1284663008691	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1284663008692	Walker B; other site
1284663008693	D-loop; other site
1284663008694	H-loop/switch region; other site
1284663008695	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1284663008696	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1284663008697	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1284663008698	Walker A/P-loop; other site
1284663008699	ATP binding site [chemical binding]; other site
1284663008700	Q-loop/lid; other site
1284663008701	ABC transporter signature motif; other site
1284663008702	Walker B; other site
1284663008703	D-loop; other site
1284663008704	H-loop/switch region; other site
1284663008705	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1284663008706	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1284663008707	Walker A/P-loop; other site
1284663008708	ATP binding site [chemical binding]; other site
1284663008709	Q-loop/lid; other site
1284663008710	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1284663008711	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1284663008712	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663008713	dimer interface [polypeptide binding]; other site
1284663008714	conserved gate region; other site
1284663008715	putative PBP binding loops; other site
1284663008716	ABC-ATPase subunit interface; other site
1284663008717	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1284663008718	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1284663008719	dimer interface [polypeptide binding]; other site
1284663008720	conserved gate region; other site
1284663008721	putative PBP binding loops; other site
1284663008722	ABC-ATPase subunit interface; other site
1284663008723	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1284663008724	peptide binding site [polypeptide binding]; other site
1284663008725	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1284663008726	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1284663008727	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1284663008728	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1284663008729	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1284663008730	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1284663008731	putative active site [active]
1284663008732	catalytic site [active]
1284663008733	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1284663008734	putative active site [active]
1284663008735	catalytic site [active]
1284663008736	amino acid transporter; Region: 2A0306; TIGR00909
1284663008737	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1284663008738	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1284663008739	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1284663008740	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1284663008741	K+ potassium transporter; Region: K_trans; pfam02705
1284663008742	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1284663008743	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1284663008744	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1284663008745	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1284663008746	Cation efflux family; Region: Cation_efflux; pfam01545
1284663008747	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1284663008748	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1284663008749	substrate binding site [chemical binding]; other site
1284663008750	THF binding site; other site
1284663008751	zinc-binding site [ion binding]; other site
1284663008752	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1284663008753	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1284663008754	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1284663008755	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1284663008756	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1284663008757	dimerization interface [polypeptide binding]; other site
1284663008758	putative DNA binding site [nucleotide binding]; other site
1284663008759	putative Zn2+ binding site [ion binding]; other site
1284663008760	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1284663008761	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1284663008762	sequence-specific DNA binding site [nucleotide binding]; other site
1284663008763	salt bridge; other site
1284663008764	flagellar motor protein MotB; Validated; Region: motB; PRK09041
1284663008765	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
1284663008766	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1284663008767	dihydropteroate synthase; Region: DHPS; TIGR01496
1284663008768	substrate binding pocket [chemical binding]; other site
1284663008769	dimer interface [polypeptide binding]; other site
1284663008770	inhibitor binding site; inhibition site
1284663008771	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1284663008772	active site
1284663008773	dimerization interface [polypeptide binding]; other site
1284663008774	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
1284663008775	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1284663008776	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
1284663008777	GTP cyclohydrolase I; Provisional; Region: PLN03044
1284663008778	active site
1284663008779	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1284663008780	catalytic center binding site [active]
1284663008781	ATP binding site [chemical binding]; other site
1284663008782	Dihydroneopterin aldolase; Region: FolB; pfam02152
1284663008783	active site
1284663008784	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1284663008785	Colicin V production protein; Region: Colicin_V; pfam02674
1284663008786	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
1284663008787	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1284663008788	metal binding site [ion binding]; metal-binding site
1284663008789	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1284663008790	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1284663008791	putative substrate translocation pore; other site
1284663008792	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1284663008793	Beta-lactamase; Region: Beta-lactamase; pfam00144
1284663008794	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1284663008795	Pyruvate formate lyase 1; Region: PFL1; cd01678
1284663008796	coenzyme A binding site [chemical binding]; other site
1284663008797	active site
1284663008798	catalytic residues [active]
1284663008799	glycine loop; other site
1284663008800	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1284663008801	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1284663008802	FeS/SAM binding site; other site
1284663008803	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1284663008804	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1284663008805	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1284663008806	active site
1284663008807	catalytic tetrad [active]
1284663008808	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1284663008809	nucleotide binding site/active site [active]
1284663008810	HIT family signature motif; other site
1284663008811	catalytic residue [active]
1284663008812	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1284663008813	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1284663008814	active site
1284663008815	catalytic triad [active]
1284663008816	oxyanion hole [active]
1284663008817	BCCT family transporter; Region: BCCT; pfam02028
1284663008818	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1284663008819	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1284663008820	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1284663008821	Protein of unknown function (DUF419); Region: DUF419; cl15265
1284663008822	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
1284663008823	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
1284663008824	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1284663008825	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
1284663008826	active site
1284663008827	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
1284663008828	potential frameshift: common BLAST hit: Mobilization protein MobC
1284663008829	potential frameshift: common BLAST hit: Transposase
1284663008830	potential frameshift: common BLAST hit: HD domain protein
1284663008831	potential frameshift: common BLAST hit: DNA topoisomerase
1284663008832	potential frameshift: common BLAST hit: Putative transposase
1284663008833	potential frameshift: common BLAST hit: Mg2+ transporter protein CorA family protein
1284663008834	potential frameshift: common BLAST hit: Transposase