-- dump date 20140619_124327 -- class Genbank::CDS -- table cds_note -- id note YP_001270614.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_001270615.1 TIGRFAM: DNA polymerase III, beta subunit; PFAM: DNA polymerase III, beta chain YP_001270616.1 TIGRFAM: S4 region, YaaA YP_001270617.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_001270618.1 TIGRFAM: DNA gyrase, B subunit; PFAM: DNA gyrase, subunit B domain protein; ATP-binding region, ATPase domain protein domain protein; TOPRIM domain protein; DNA topoisomerase, type IIA, subunit B, region 2 domain protein; SMART: DNA topoisomerase II YP_001270619.1 TIGRFAM: DNA gyrase, A subunit; PFAM: DNA gyrase/topoisomerase IV, subunit A; DNA gyrase C-terminal repeat, beta-propeller YP_001270620.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001270621.1 TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n; nucleic acid binding, OB-fold, tRNA/helicase-type YP_001270622.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001270623.1 PFAM: phosphoesterase, RecJ domain protein; phosphoesterase, DHHA1 YP_001270624.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001270625.1 TIGRFAM: replicative DNA helicase; PFAM: DnaB domain protein helicase, N-terminal domain protein; DnaB domain protein helicase, C-terminal domain protein YP_001270626.1 PFAM: major facilitator superfamily MFS_1 YP_001270628.1 PFAM: protein of unknown function DUF344 YP_001270629.1 PFAM: helix-turn-helix domain protein YP_001270630.1 PFAM: regulatory protein, MarR YP_001270631.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001270632.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001270633.1 TIGRFAM: PAS sensor protein; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; PAS fold domain protein; SMART: PAS domain containing protein YP_001270634.1 PFAM: YycH family protein YP_001270636.1 PFAM: beta-lactamase domain protein YP_001270637.1 PFAM: peptidase S1 and S6, chymotrypsin/Hap; SMART: PDZ/DHR/GLGF domain protein YP_001270638.1 PFAM: phosphatidylglycerophosphatase A YP_001270639.1 PFAM: protein of unknown function DUF534 YP_001270640.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_001270642.1 PFAM: NAD(P)H dehydrogenase (quinone); NADPH-dependent FMN reductase YP_001270643.1 PFAM: iron-containing alcohol dehydrogenase YP_001270644.1 PFAM: sugar transport family protein YP_001270646.1 PFAM: NADP oxidoreductase, coenzyme F420-dependent YP_001270647.1 PFAM: aldehyde dehydrogenase YP_001270648.1 TIGRFAM: efflux transporter, RND family, MFP subunit YP_001270649.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001270650.1 PFAM: protein of unknown function DUF214 YP_001270655.1 PFAM: OsmC family protein YP_001270656.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001270657.1 PFAM: aminotransferase, class I and II YP_001270658.1 PFAM: AAA ATPase, central domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase YP_001270660.1 PFAM: GCN5-related N-acetyltransferase YP_001270661.1 PFAM: phospholipase D/Transphosphatidylase YP_001270663.1 TIGRFAM: Recombination helicase AddA; PFAM: UvrD/REP helicase YP_001270664.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001270665.1 TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase YP_001270666.1 PFAM: major facilitator superfamily MFS_1 YP_001270667.1 PFAM: glycoside hydrolase, family 65 domain protein; glycoside hydrolase family 65, central catalytic; glycoside hydrolase family 65 domain protein YP_001270668.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; beta-phosphoglucomutase; beta-phosphoglucomutase family hydrolase; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001270670.1 PFAM: response regulator receiver YP_001270671.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein YP_001270673.1 PFAM: glutamate--cysteine ligase YP_001270674.1 PFAM: transposase IS200-family protein YP_001270675.1 PFAM: glutamine amidotransferase class-I; peptidase C26 YP_001270676.1 PFAM: aldo/keto reductase YP_001270677.1 PFAM: glycerophosphoryl diester phosphodiesterase YP_001270679.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region YP_001270680.1 TIGRFAM: guanosine monophosphate reductase; PFAM: IMP dehydrogenase/GMP reductase YP_001270681.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_001270683.1 PFAM: phosphoribosyltransferase YP_001270685.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001270686.1 PFAM: transposase IS200-family protein YP_001270687.1 PFAM: glutamine amidotransferase class-I; peptidase C26 YP_001270688.1 PFAM: amino acid permease-associated region YP_001270692.1 PFAM: glycosyl transferase, group 1; Protein of unknown function DUF1975 YP_001270693.1 PFAM: glycosyl transferase, group 1; Protein of unknown function DUF1975 YP_001270695.1 PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001270696.1 PFAM: major facilitator superfamily MFS_1 YP_001270697.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_001270698.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001270699.1 PFAM: major facilitator superfamily MFS_1 YP_001270700.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001270701.1 TIGRFAM: RNA methyltransferase, TrmA family; PFAM: deoxyribonuclease/rho motif-related TRAM; (Uracil-5)-methyltransferase YP_001270702.1 PFAM: NADPH-dependent FMN reductase YP_001270703.1 PFAM: NAD(P)H dehydrogenase (quinone); NADPH-dependent FMN reductase YP_001270704.1 PFAM: ApbE family lipoprotein YP_001270705.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein YP_001270706.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001270707.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; extracellular solute-binding protein, family 3; SMART: ionotropic glutamate receptor YP_001270708.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001270709.1 PFAM: amino acid permease-associated region YP_001270710.1 PFAM: Na+ dependent nucleoside transporter; Na+ dependent nucleoside transporter domain protein YP_001270711.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides YP_001270712.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA YP_001270713.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_001270714.1 TIGRFAM: parB-like partition protein; PFAM: ParB domain protein nuclease YP_001270715.1 PFAM: Cobyrinic acid a,c-diamide synthase YP_001270716.1 TIGRFAM: parB-like partition protein; PFAM: ParB domain protein nuclease YP_001270717.1 PFAM: protein of unknown function DUF951 YP_001270718.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001270719.1 PFAM: membrane protein of unknown function UCP033111 YP_001270720.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_001270721.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_001270722.1 TIGRFAM: pyrimidine-nucleoside phosphorylase; PFAM: glycosyl transferase, family 3; Pyrimidine nucleoside phosphorylase, C-terminal domain YP_001270723.1 TIGRFAM: purine nucleoside phosphorylase; PFAM: purine or other phosphorylase, family 1 YP_001270724.1 PFAM: sugar-binding domain protein YP_001270725.1 PFAM: IMP dehydrogenase/GMP reductase; deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase YP_001270726.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001270727.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein YP_001270728.1 PFAM: AzlC family protein YP_001270729.1 PFAM: branched-chain amino acid transport YP_001270732.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_001270733.1 TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase YP_001270734.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits YP_001270735.1 TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase YP_001270736.1 TIGRFAM: orotate phosphoribosyltransferase; PFAM: phosphoribosyltransferase YP_001270738.1 PFAM: Cyclopropane-fatty-acyl-phospholipid synthase; Methyltransferase type 11; Methyltransferase type 12 YP_001270739.1 PFAM: protein of unknown function UPF0118 YP_001270740.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate YP_001270741.1 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase YP_001270742.1 PFAM: alpha-acetolactate decarboxylase YP_001270743.1 TIGRFAM: phosphoribosylaminoimidazole carboxylase, catalytic subunit; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase YP_001270744.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_001270745.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_001270746.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001270747.1 TIGRFAM: phosphoribosylformylglycinamidine synthase, purS; PFAM: phosphoribosylformylglycinamidine synthetase PurS YP_001270748.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001270749.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001270750.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_001270751.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_001270752.1 TIGRFAM: phosphoribosylglycinamide formyltransferase; PFAM: formyl transferase domain protein YP_001270753.1 involved in de novo purine biosynthesis YP_001270754.1 TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase YP_001270755.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_001270757.1 TIGRFAM: tyrosyl-tRNA synthetase; PFAM: aminoacyl-tRNA synthetase, class Ib; RNA-binding S4 domain protein YP_001270759.1 PFAM: IS66 Orf2 family protein YP_001270760.1 PFAM: transposase IS66 YP_001270762.1 PFAM: Integrase, catalytic region YP_001270763.1 PFAM: NUDIX hydrolase YP_001270764.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_001270765.1 PFAM: isochorismatase hydrolase YP_001270766.1 PFAM: ADP-ribosylation/Crystallin J1 YP_001270767.1 PFAM: permease for cytosine/purines, uracil, thiamine, allantoin YP_001270768.1 PFAM: PfkB domain protein YP_001270769.1 PFAM: helix-turn-helix, HxlR type YP_001270770.1 PFAM: General substrate transporter; major facilitator superfamily MFS_1 YP_001270771.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR YP_001270773.1 PFAM: dihydrodipicolinate reductase YP_001270774.1 PFAM: cytochrome b5 YP_001270775.1 PFAM: Na+/H+ antiporter NhaC YP_001270776.1 PFAM: protein of unknown function DUF1234 YP_001270778.1 PFAM: triosephosphate isomerase YP_001270779.1 PFAM: aldo/keto reductase YP_001270780.1 SMART: phosphoesterase, PA-phosphatase related YP_001270781.1 PFAM: helicase domain protein; type III restriction protein, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001270783.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region YP_001270786.1 PFAM: peptidase M10A and M12B, matrixin and adamalysin YP_001270787.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; cadmium-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; E1-E2 ATPase-associated domain protein YP_001270788.1 PFAM: metalloenzyme domain protein; Phosphopentomutase N-terminal domain protein YP_001270789.1 PFAM: 3-beta hydroxysteroid dehydrogenase/isomerase; NmrA family protein YP_001270790.1 PFAM: protein of unknown function UPF0074 YP_001270791.1 PFAM: Substrate-binding region of ABC-type glycine betaine transport system YP_001270792.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001270793.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001270794.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001270795.1 TIGRFAM: methionine-R-sulfoxide reductase; PFAM: Methionine sulfoxide reductase B YP_001270796.1 PFAM: Chloride channel, core YP_001270797.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_001270798.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001270799.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001270800.1 PFAM: NLPA lipoprotein YP_001270801.1 PFAM: Lactate/malate dehydrogenase YP_001270802.1 PFAM: General substrate transporter; major facilitator superfamily MFS_1 YP_001270803.1 PFAM: FMN-binding domain protein YP_001270804.1 TIGRFAM: endonuclease III; PFAM: helix-hairpin-helix motif; HhH-GPD family protein; SMART: iron-sulfur cluster loop YP_001270805.1 PFAM: amino acid permease-associated region YP_001270806.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_001270807.1 PFAM: sodium/hydrogen exchanger YP_001270809.1 PFAM: nucleoside diphosphate kinase YP_001270810.1 PFAM: DNA methylase N-4/N-6 domain protein YP_001270811.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001270812.1 PFAM: Ppx/GppA phosphatase YP_001270813.1 TIGRFAM: hydroxymethylglutaryl-CoA reductase, degradative YP_001270815.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_001270816.1 PFAM: protein of unknown function DUF72 YP_001270817.1 TIGRFAM: methionyl-tRNA synthetase; methionyl-tRNA synthetase, beta subunit; PFAM: t-RNA-binding domain protein; tRNA synthetase class I (M) YP_001270818.1 TIGRFAM: hydrolase, TatD family; PFAM: TatD-related deoxyribonuclease YP_001270819.1 TIGRFAM: primase/topoisomerase like protein; PFAM: TOPRIM domain protein; SMART: Toprim sub domain protein YP_001270820.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001270821.1 PFAM: protein of unknown function DUF1021 YP_001270822.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_001270823.1 PFAM: periplasmic solute binding protein YP_001270824.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001270825.1 PFAM: ABC-3 protein YP_001270826.1 TIGRFAM: pur operon repressor; PFAM: phosphoribosyltransferase; purine repressor-like YP_001270827.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_001270828.1 TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase YP_001270830.1 TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase, type 3 YP_001270831.1 PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001270832.1 PFAM: biotin/lipoate A/B protein ligase YP_001270833.1 PFAM: transposase IS200-family protein YP_001270834.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001270835.1 PFAM: Domain of unknown function DUF1934 YP_001270836.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling YP_001270837.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001270838.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein YP_001270839.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001270840.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001270842.1 PFAM: hydrolase family protein YP_001270843.1 TIGRFAM: sortase family protein; PFAM: peptidase C60, sortase A and B YP_001270844.1 PFAM: triosephosphate isomerase YP_001270845.1 TIGRFAM: ketose-bisphosphate aldolase; fructose-1,6-bisphosphate aldolase, class II; PFAM: ketose-bisphosphate aldolase, class-II YP_001270846.1 PFAM: Phosphoglycerate mutase YP_001270847.1 PFAM: low molecular weight phosphotyrosine protein phosphatase YP_001270848.1 PFAM: LemA family protein YP_001270849.1 metalloprotease YP_001270850.1 TIGRFAM: UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase, middle domain protein YP_001270851.1 PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001270852.1 PFAM: Integrase, catalytic region YP_001270853.1 PFAM: glutaminase YP_001270854.1 PFAM: transposase IS200-family protein YP_001270855.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein YP_001270856.1 PFAM: DltD, C-terminal domain protein; DltD, N-terminal domain protein; DltD, central domain protein YP_001270857.1 TIGRFAM: D-alanyl carrier protein; PFAM: phosphopantetheine-binding YP_001270858.1 PFAM: membrane bound O-acyl transferase, MBOAT family protein YP_001270859.1 TIGRFAM: amino acid adenylation domain; D-alanine-activating enzyme; PFAM: AMP-dependent synthetase and ligase YP_001270861.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_001270862.1 TIGRFAM: alanine racemase; PFAM: alanine racemase domain protein YP_001270863.1 PFAM: PemK family protein YP_001270864.1 PFAM: permease for cytosine/purines, uracil, thiamine, allantoin YP_001270865.1 PFAM: amidohydrolase; Amidohydrolase 3 YP_001270866.1 PFAM: Hydratase/decarboxylase YP_001270867.1 PFAM: CBS domain containing protein YP_001270868.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001270869.1 TIGRFAM: transcription-repair coupling factor; PFAM: helicase domain protein; transcription factor CarD; TRCF domain protein; type III restriction protein, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001270870.1 PFAM: RNA-binding S4 domain protein YP_001270871.1 PFAM: Septum formation initiator YP_001270872.1 PFAM: RNA binding S1 domain protein YP_001270873.1 TIGRFAM: tRNA(Ile)-lysidine synthetase; PFAM: PP-loop domain protein YP_001270874.1 TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase YP_001270875.1 TIGRFAM: ATP-dependent metalloprotease FtsH; PFAM: peptidase M41; AAA ATPase, central domain protein; peptidase M41, FtsH extracellular; SMART: AAA ATPase YP_001270876.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_001270877.1 TIGRFAM: TIM-barrel protein, nifR3 family; PFAM: dihydrouridine synthase, DuS; dihydroorotate dehydrogenase YP_001270878.1 TIGRFAM: lysyl-tRNA synthetase; PFAM: tRNA synthetase, class II (D, K and N); nucleic acid binding, OB-fold, tRNA/helicase-type YP_001270881.1 PFAM: IS66 Orf2 family protein YP_001270882.1 PFAM: transposase IS66 YP_001270884.1 TIGRFAM: amino acid/peptide transporter; PFAM: TGF-beta receptor, type I/II extracellular region YP_001270885.1 PFAM: metallophosphoesterase YP_001270887.1 PFAM: major facilitator superfamily MFS_1 YP_001270888.1 TIGRFAM: YidE/YbjL duplication; PFAM: TrkA-C domain protein; YidE/YbjL duplication domain protein YP_001270889.1 TIGRFAM: aspartate racemase; PFAM: Asp/Glu racemase YP_001270890.1 PFAM: regulatory protein GntR, HTH; UbiC transcription regulator-associated domain protein YP_001270891.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_001270892.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_001270893.1 PFAM: RNA binding S1 domain protein; SMART: Resolvase, RNase H domain protein fold YP_001270894.1 PFAM: protein of unknown function DUF335, SprT; SMART: protein of unknown function SprT YP_001270895.1 PFAM: glycoside hydrolase family 2, immunoglobulin domain protein beta-sandwich; glycoside hydrolase family 2, TIM barrel; glycoside hydrolase family 2, sugar binding YP_001270896.1 PFAM: glycoside hydrolase, family 42, domain 5, loop region YP_001270898.1 TIGRFAM: phosphoglycerate mutase 1 family; PFAM: Phosphoglycerate mutase YP_001270900.1 PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; DegT/DnrJ/EryC1/StrS aminotransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class-III YP_001270901.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component YP_001270902.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001270903.1 PFAM: extracellular solute-binding protein, family 3 YP_001270904.1 PFAM: peptidase C1B, bleomycin hydrolase YP_001270905.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_001270907.1 PFAM: deoxyUTP pyrophosphatase YP_001270908.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001270909.1 PFAM: PilT protein domain protein; SMART: Nucleotide binding protein, PINc YP_001270910.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001270911.1 PFAM: ribonuclease III YP_001270912.1 TIGRFAM: RNA methyltransferase, TrmH family, group 3; PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase, substrate binding YP_001270913.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_001270914.1 TIGRFAM: transcription termination/antitermination factor NusG; PFAM: transcription antitermination protein NusG; KOW domain protein; SMART: NGN domain protein; KOW (Kyrpides, Ouzounis, Woese) domain protein YP_001270915.1 binds directly to 23S ribosomal RNA YP_001270916.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001270917.1 PFAM: aminotransferase, class I and II YP_001270918.1 PFAM: glycosyl transferase, family 2 YP_001270919.1 PFAM: UDP-N-acetylglucosamine 2-epimerase YP_001270920.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001270921.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001270924.1 TIGRFAM: large conductance mechanosensitive channel protein; PFAM: large-conductance mechanosensitive channel YP_001270925.1 PFAM: transcriptional regulator PadR family protein YP_001270928.1 PFAM: iron-containing alcohol dehydrogenase YP_001270929.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_001270930.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001270931.1 TIGRFAM: glutaredoxin-like protein NrdH; PFAM: glutaredoxin YP_001270932.1 PFAM: CMP/dCMP deaminase, zinc-binding YP_001270933.1 TIGRFAM: DNA polymerase III, subunits gamma and tau; PFAM: AAA ATPase, central domain protein; SMART: AAA ATPase YP_001270934.1 PFAM: conserved hypothetical protein 103 YP_001270935.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001270937.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_001270938.1 PFAM: protein of unknown function DUF970 YP_001270939.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_001270940.1 PFAM: protein of unknown function DUF972 YP_001270941.1 PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001270942.1 PFAM: acyl-ACP thioesterase YP_001270944.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_001270945.1 PFAM: Ppx/GppA phosphatase YP_001270946.1 TIGRFAM: UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain YP_001270947.1 PFAM: peptidase M22, glycoprotease YP_001270948.1 TIGRFAM: ribosomal-protein-alanine acetyltransferase; PFAM: GCN5-related N-acetyltransferase YP_001270949.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001270950.1 TIGRFAM: pyrroline-5-carboxylate reductase; PFAM: NADP oxidoreductase, coenzyme F420-dependent; 6-phosphogluconate dehydrogenase, NAD-binding; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein YP_001270951.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_001270952.1 TIGRFAM: glutamate 5-kinase; PFAM: aspartate/glutamate/uridylate kinase YP_001270953.1 PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase YP_001270954.1 produces methionine from 2-keto-4-methylthiobutyrate and glutamine in vitro; mutations do not affect methionine salvage in vivo however YP_001270955.1 TIGRFAM: 2-dehydropantoate 2-reductase; PFAM: Ketopantoate reductase ApbA/PanE, N-terminal domain protein; Ketopantoate reductase ApbA/PanE, C-terminal domain protein YP_001270956.1 PFAM: transposase, IS4 family protein YP_001270957.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001270958.1 modulates transcription in response to the NADH/NAD(+) redox state YP_001270959.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_001270960.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001270961.1 PFAM: YbaK/prolyl-tRNA synthetase associated region YP_001270962.1 PFAM: amino acid permease-associated region YP_001270963.1 PFAM: amino acid permease-associated region YP_001270965.1 PFAM: regulatory protein, MarR YP_001270966.1 PFAM: major facilitator superfamily MFS_1 YP_001270967.1 PFAM: protein of unknown function UPF0029; Domain of unknown function DUF1949 YP_001270968.1 PFAM: helicase domain protein; type III restriction protein, res subunit; SMART: DEAD-like helicases-like YP_001270970.1 TIGRFAM: ribosomal subunit interface protein; PFAM: sigma 54 modulation protein/ribosomal protein S30EA YP_001270971.1 TIGRFAM: preprotein translocase, SecA subunit; PFAM: helicase domain protein; SecA DEAD domain protein; SecA Wing and Scaffold; SecA preprotein cross-linking region YP_001270972.1 TIGRFAM: peptide chain release factor 2; PFAM: Class I peptide chain release factor; PCRF domain protein YP_001270973.1 PFAM: PspC domain protein YP_001270974.1 PFAM: membrane protein of unknown function YP_001270975.1 TIGRFAM: HPr(Ser) kinase/phosphatase; PFAM: HPr serine kinase domain protein YP_001270976.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_001270977.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_001270978.1 TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase YP_001270979.1 PFAM: protein of unknown function DUF162 YP_001270980.1 TIGRFAM: iron-sulfur cluster binding protein; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; protein of unknown function DUF162 YP_001270981.1 PFAM: protein of unknown function DUF224, cysteine-rich region domain protein YP_001270982.1 TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; HI0933 family protein YP_001270983.1 TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein YP_001270984.1 PFAM: extracellular solute-binding protein, family 3 YP_001270985.1 PFAM: thioesterase superfamily protein YP_001270986.1 PFAM: phosphoglucomutase/phosphomannomutase C terminal; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III YP_001270989.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001270990.1 TIGRFAM: excinuclease ABC, A subunit; PFAM: ABC transporter related; SMART: AAA ATPase YP_001270991.1 PFAM: amino acid permease-associated region YP_001270992.1 PFAM: uncharacterised P-loop ATPase protein UPF0042 YP_001270993.1 PFAM: CofD YP_001270994.1 PFAM: protein of unknown function DUF199 YP_001270995.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_001270996.1 PFAM: amino acid permease-associated region YP_001270997.1 PFAM: TrkA-C domain protein; Chloride channel, core YP_001270998.1 TIGRFAM: preprotein translocase, SecG subunit; PFAM: Preprotein translocase SecG subunit YP_001271000.1 TIGRFAM: VacB and RNase II family 3'-5' exoribonuclease; ribonuclease R; PFAM: ribonuclease II; RNA binding S1 domain protein; Ribonuclease B, OB region N-terminal domain YP_001271001.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001271003.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_001271004.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta YP_001271005.1 PFAM: protein of unknown function UPF0079 YP_001271006.1 PFAM: GCN5-related N-acetyltransferase YP_001271008.1 PFAM: Exonuclease, RNase T and DNA polymerase III; SMART: Exonuclease YP_001271009.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_001271010.1 TIGRFAM: ribokinase; PFAM: PfkB domain protein; Phosphomethylpyrimidine kinase type-1 YP_001271011.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source YP_001271012.1 TIGRFAM: L-fucose transporter; PFAM: major facilitator superfamily MFS_1 YP_001271013.1 PFAM: protein of unknown function DUF147 YP_001271014.1 PFAM: YbbR family protein YP_001271015.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_001271016.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_001271018.1 PFAM: acyltransferase 3 YP_001271019.1 PFAM: regulatory protein, MarR YP_001271020.1 TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase, type 3 YP_001271021.1 PFAM: Peptidoglycan-binding LysM YP_001271022.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001271023.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein YP_001271024.1 PFAM: sugar transport family protein YP_001271025.1 PFAM: transferase hexapeptide repeat containing protein YP_001271026.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_001271029.1 PFAM: transposase IS200-family protein YP_001271030.1 PFAM: response regulator receiver; YcbB domain YP_001271031.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_001271032.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_001271033.1 PFAM: protein of unknown function DUF6, transmembrane YP_001271034.1 PFAM: peptidase M10A and M12B, matrixin and adamalysin YP_001271037.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; copper-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; E1-E2 ATPase-associated domain protein; Haloacid dehalogenase domain protein hydrolase, type 3 YP_001271041.1 PFAM: transposase, IS204/IS1001/IS1096/IS1165 family protein YP_001271046.1 PFAM: Integrase, catalytic region YP_001271049.1 PFAM: beta-lactamase YP_001271050.1 catalyzes the degradation of arginine to citruline and ammonia YP_001271051.1 PFAM: arginine repressor YP_001271052.1 PFAM: amino acid permease-associated region YP_001271053.1 PFAM: amino acid permease-associated region YP_001271054.1 PFAM: CobB/CobQ domain protein glutamine amidotransferase YP_001271055.1 PFAM: Mur ligase, middle domain protein; domain of unknown function DUF1727 YP_001271056.1 PFAM: thymidine kinase YP_001271057.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001271058.1 TIGRFAM: modification methylase, HemK family; PFAM: methyltransferase small YP_001271059.1 TIGRFAM: Sua5/YciO/YrdC/YwlC family protein; PFAM: SUA5 domain protein; SUA5/yciO/yrdC, N-terminal domain YP_001271060.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001271061.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_001271062.1 TIGRFAM: phosphoenolpyruvate-protein phosphotransferase; PFAM: PEP-utilizing protein; PEP-utilising protein, mobile region; PEP-utilising protein domain protein YP_001271063.1 PFAM: YibE/F family protein YP_001271064.1 PFAM: YibE/F family protein YP_001271065.1 TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease YP_001271066.1 TIGRFAM: ATP synthase F0, A subunit; PFAM: H+-transporting two-sector ATPase, A subunit YP_001271067.1 TIGRFAM: ATP synthase F0, C subunit; PFAM: H+-transporting two-sector ATPase, C subunit YP_001271068.1 TIGRFAM: ATP synthase F0, B subunit; PFAM: H+-transporting two-sector ATPase, B/B' subunit YP_001271069.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_001271070.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001271071.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_001271072.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001271073.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_001271074.1 TIGRFAM: conserved hypothetical integral membrane protein; PFAM: conserved hypothetical protein, integral membrane YwzB YP_001271075.1 TIGRFAM: UDP-N-acetylglucosamine 1-carboxyvinyltransferase; PFAM: EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) YP_001271076.1 TIGRFAM: cell shape determining protein, MreB/Mrl family; PFAM: cell division protein FtsA; cell shape determining protein MreB/Mrl YP_001271077.1 PFAM: protein of unknown function DUF37 YP_001271079.1 PFAM: cell cycle protein YP_001271080.1 PFAM: glycine cleavage H-protein YP_001271082.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001271083.1 PFAM: helix-turn-helix domain protein; SMART: Tetratricopeptide domain protein YP_001271084.1 TIGRFAM: sugar transporter; PFAM: General substrate transporter; major facilitator superfamily MFS_1 YP_001271085.1 PFAM: carbohydrate kinase, FGGY YP_001271086.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_001271087.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism YP_001271088.1 PFAM: transferase hexapeptide repeat containing protein YP_001271089.1 PFAM: aldo/keto reductase YP_001271090.1 PFAM: regulatory protein GntR, HTH; periplasmic binding protein/LacI transcriptional regulator YP_001271091.1 PFAM: UspA domain protein YP_001271093.1 PFAM: AAA ATPase, central domain protein; SMART: AAA ATPase YP_001271094.1 PFAM: protein of unknown function DUF1694 YP_001271096.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase YP_001271098.1 PFAM: protein of unknown function DUF328 YP_001271099.1 catalyzes the formation of formyl-CoA from oxalyl-CoA YP_001271100.1 PFAM: L-carnitine dehydratase/bile acid-inducible protein F YP_001271101.1 PFAM: transposase IS200-family protein YP_001271103.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein YP_001271104.1 PFAM: Xanthine/uracil/vitamin C permease; sulphate transporter YP_001271105.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001271106.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation YP_001271107.1 PFAM: aminotransferase, class V YP_001271108.1 Required for the synthesis of the thiazole moiety YP_001271109.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001271110.1 PFAM: cytochrome bd ubiquinol oxidase, subunit I YP_001271111.1 TIGRFAM: cytochrome d ubiquinol oxidase, subunit II; PFAM: cytochrome bd ubiquinol oxidase, subunit II YP_001271112.1 TIGRFAM: ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD; PFAM: ABC transporter related; SMART: AAA ATPase YP_001271113.1 TIGRFAM: ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC; PFAM: ABC transporter related; SMART: AAA ATPase YP_001271114.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001271115.1 TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase, middle domain protein YP_001271116.1 PFAM: DNA repair protein RadC YP_001271117.1 functions in MreBCD complex in some organisms YP_001271118.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_001271120.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component YP_001271121.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001271122.1 PFAM: extracellular solute-binding protein, family 3 YP_001271123.1 PFAM: peptidase M16 domain protein YP_001271124.1 PFAM: peptidase M16 domain protein YP_001271126.1 TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase YP_001271127.1 TIGRFAM: competence/damage-inducible protein CinA; PFAM: molybdopterin binding domain; CinA domain protein YP_001271128.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001271129.1 TIGRFAM: metal dependent phophohydrolase; PFAM: KH, type 1, domain protein; metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region; KH domain protein YP_001271130.1 This protein performs the mismatch recognition step during the DNA repair process YP_001271131.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_001271132.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001271133.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001271134.1 TIGRFAM: tRNA-guanine transglycosylase, various specificities; PFAM: Queuine/other tRNA-ribosyltransferase YP_001271135.1 TIGRFAM: preprotein translocase, YajC subunit; PFAM: YajC family protein YP_001271136.1 PFAM: phosphoesterase, RecJ domain protein; phosphoesterase, DHHA1 YP_001271137.1 PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001271138.1 TIGRFAM: alanyl-tRNA synthetase; PFAM: alanyl-tRNA synthetase, class IIc; phosphoesterase, DHHA1; Threonyl/alanyl tRNA synthetase, SAD YP_001271139.1 PFAM: protein of unknown function DUF965 YP_001271140.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_001271141.1 PFAM: protein of unknown function DUF1292 YP_001271142.1 PFAM: Colicin V production protein YP_001271143.1 TIGRFAM: MutS2 family protein; PFAM: DNA mismatch repair protein MutS domain protein; Smr protein/MutS2; SMART: MutS III domain protein YP_001271144.1 TIGRFAM: thioredoxin; PFAM: Thioredoxin domain YP_001271146.1 TIGRFAM: glutamate racemase; PFAM: Asp/Glu racemase YP_001271147.1 TIGRFAM: non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; PFAM: Ham1 family protein YP_001271148.1 TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase YP_001271149.1 PFAM: CBS domain containing protein YP_001271150.1 PFAM: sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase, type 3 YP_001271151.1 PFAM: MscS Mechanosensitive ion channel YP_001271152.1 PFAM: protein of unknown function DUF948 YP_001271154.1 PFAM: creatinase; peptidase M24 YP_001271155.1 TIGRFAM: catabolite control protein A; PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001271157.1 PFAM: protein of unknown function DUF28 YP_001271158.1 PFAM: type II secretion system protein E; SMART: AAA ATPase YP_001271159.1 PFAM: type II secretion system protein YP_001271165.1 TIGRFAM: acetate kinase; PFAM: acetate and butyrate kinase YP_001271167.1 PFAM: protein of unknown function DUF1027 YP_001271168.1 TIGRFAM: HAD-superfamily subfamily IIA hydrolase like protein; HAD-superfamily hydrolase, subfamily IIA; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001271169.1 TIGRFAM: integral membrane protein TIGR01906; PFAM: Integral membrane protein 1906 YP_001271170.1 PFAM: SNARE associated Golgi protein YP_001271172.1 PFAM: arsenate reductase and related YP_001271173.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence YP_001271174.1 PFAM: Competence CoiA family protein YP_001271175.1 PFAM: peptidase U34, dipeptidase YP_001271177.1 PFAM: RelA/SpoT domain protein YP_001271178.1 catalyzes the phosphorylation of NAD to NADP YP_001271179.1 TIGRFAM: pseudouridine synthase, RluA family; PFAM: pseudouridine synthase YP_001271180.1 PFAM: IS66 Orf2 family protein YP_001271183.1 PFAM: Methyltransferase type 11 YP_001271184.1 TIGRFAM: RNA methyltransferase, TrmH family, group 2; PFAM: tRNA/rRNA methyltransferase (SpoU) YP_001271185.1 PFAM: cell divisionFtsK/SpoIIIE; SMART: AAA ATPase YP_001271188.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_001271189.1 TIGRFAM: S-adenosyl-methyltransferase MraW; PFAM: methyltransferase YP_001271190.1 TIGRFAM: cell division protein FtsL; PFAM: Septum formation initiator YP_001271191.1 PFAM: penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain; PASTA domain containing protein YP_001271192.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001271193.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_001271194.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001271195.1 PFAM: cell division protein FtsQ; Polypeptide-transport-associated domain protein, FtsQ-type YP_001271196.1 PFAM: cell division protein FtsA YP_001271197.1 TIGRFAM: cell division protein FtsZ; PFAM: Tubulin/FtsZ, GTPase; Tubulin/FtsZ domain protein YP_001271198.1 PFAM: protein of unknown function DUF552 YP_001271199.1 PFAM: hypothetical protein YP_001271200.1 PFAM: RNA-binding S4 domain protein YP_001271201.1 PFAM: DivIVA family protein YP_001271202.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_001271203.1 PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein YP_001271204.1 PFAM: NUDIX hydrolase YP_001271206.1 PFAM: purine or other phosphorylase, family 1 YP_001271207.1 PFAM: aminotransferase, class V YP_001271209.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001271210.1 PFAM: Phosphoglycerate mutase YP_001271211.1 PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein YP_001271212.1 TIGRFAM: helicase, RecD/TraA family; SMART: AAA ATPase YP_001271213.1 TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase YP_001271214.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_001271215.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive YP_001271216.1 TIGRFAM: diaminopimelate decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2 YP_001271217.1 PFAM: transferase hexapeptide repeat containing protein; Tetrahydrodipicolinate succinyltransferase N-terminal domain protein YP_001271218.1 TIGRFAM: amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein YP_001271219.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001271220.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_001271221.1 PFAM: aminotransferase, class I and II YP_001271222.1 TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, NAD - binding; Semialdehyde dehydrogenase, dimerisation region YP_001271223.1 PFAM: Gluconate transporter; Citrate transporter YP_001271224.1 PFAM: glycerate kinase YP_001271227.1 PFAM: NLP/P60 protein; Peptidoglycan-binding LysM YP_001271229.1 PFAM: diacylglycerol kinase, catalytic region YP_001271230.1 PFAM: protein of unknown function DUF1447 YP_001271232.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001271233.1 PFAM: dehydrogenase, E1 component YP_001271234.1 PFAM: Transketolase, central region; Transketolase domain protein YP_001271235.1 PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein YP_001271236.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001271237.1 PFAM: protein of unknown function UPF0223 YP_001271238.1 PFAM: inositol monophosphatase YP_001271239.1 TIGRFAM: small GTP-binding protein; GTP-binding protein TypA; PFAM: elongation factor G domain protein; protein synthesis factor, GTP-binding; GTP-binding protein, HSR1-related; elongation factor Tu, domain 2 protein YP_001271240.1 PFAM: cell cycle protein YP_001271242.1 TIGRFAM: methyltransferase; PFAM: conserved hypothetical protein 95 YP_001271243.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_001271245.1 TIGRFAM: competence protein ComEA helix-hairpin-helix repeat protein; PFAM: helix-hairpin-helix motif; SMART: Helix-hairpin-helix DNA-binding, class 1 YP_001271246.1 TIGRFAM: ComE operon protein 2; PFAM: CMP/dCMP deaminase, zinc-binding YP_001271247.1 TIGRFAM: DNA internalization-related competence protein ComEC/Rec2; PFAM: beta-lactamase domain protein; ComEC/Rec2-related protein YP_001271248.1 TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta YP_001271249.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_001271250.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_001271251.1 PFAM: beta-lactamase domain protein; RNA-metabolising metallo-beta-lactamase YP_001271253.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001271254.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001271255.1 binds and unfolds substrates as part of the ClpXP protease YP_001271256.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_001271257.1 PFAM: MazG nucleotide pyrophosphohydrolase YP_001271259.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001271260.1 TIGRFAM: small GTP-binding protein; GTP-binding protein Obg/CgtA; PFAM: GTP-binding protein, HSR1-related; GTP1/OBG sub domain protein; GTP1/OBG-like YP_001271261.1 TIGRFAM: ribonuclease Z; PFAM: beta-lactamase domain protein YP_001271262.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR YP_001271263.1 PFAM: phosphoesterase, RecJ domain protein YP_001271267.1 TIGRFAM: phage/plasmid primase, P4 family YP_001271268.1 TIGRFAM: phage head-tail adaptor, putative YP_001271270.1 PFAM: HNH endonuclease; SMART: HNH nuclease YP_001271271.1 TIGRFAM: phage terminase, small subunit, putative, P27 family; PFAM: phage terminase, small subunit, putative, P27 YP_001271272.1 PFAM: phage Terminase YP_001271273.1 TIGRFAM: phage portal protein, HK97 family; PFAM: phage portal protein YP_001271274.1 TIGRFAM: phage prohead protease, HK97 family; phage major capsid protein, HK97 family; PFAM: peptidase U35, phage prohead HK97; phage major capsid protein, HK97 YP_001271275.1 TIGRFAM: phage transcriptional regulator, RinA family YP_001271276.1 TIGRFAM: uncharacterized phage protein (possible DNA packaging); PFAM: Uncharacterized phage protein (possible DNA packaging) YP_001271277.1 PFAM: ribonuclease H YP_001271278.1 TIGRFAM: hydroxymethylglutaryl-CoA synthase; PFAM: Hydroxymethylglutaryl-coenzyme A synthase, N-terminal domain; Hydroxymethylglutaryl-coenzyme A synthase C terminal domain protein YP_001271279.1 Represses a number of genes involved in the response to DNA damage YP_001271280.1 PFAM: protein of unknown function DUF896 YP_001271281.1 PFAM: protein of unknown function UPF0154 YP_001271282.1 PFAM: phospholipid/glycerol acyltransferase YP_001271284.1 PFAM: Excinuclease ABC, C subunit domain protein YP_001271285.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001271286.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001271287.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001271288.1 Catalyzes the phosphorylation of UMP to UDP YP_001271289.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001271290.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein YP_001271291.1 PFAM: transposase IS200-family protein YP_001271292.1 TIGRFAM: undecaprenyl diphosphate synthase; PFAM: Di-trans-poly-cis-decaprenylcistransferase YP_001271293.1 PFAM: phosphatidate cytidylyltransferase YP_001271294.1 TIGRFAM: membrane-associated zinc metalloprotease; PFAM: PDZ/DHR/GLGF domain protein; peptidase M50 YP_001271295.1 TIGRFAM: prolyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S); Anticodon-binding domain protein; YbaK/prolyl-tRNA synthetase associated region YP_001271296.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity YP_001271297.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_001271298.1 TIGRFAM: transcription termination factor NusA; PFAM: RNA binding S1 domain protein; NusA N-terminal domain protein; SMART: KH domain protein YP_001271299.1 PFAM: protein of unknown function DUF448 YP_001271300.1 PFAM: ribosomal protein L7Ae/L30e/S12e/Gadd45 YP_001271301.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001271302.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_001271303.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_001271304.1 TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase / FAD synthetase YP_001271306.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons YP_001271307.1 PFAM: GrpE protein YP_001271308.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001271309.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001271310.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001271311.1 PFAM: phage integrase family protein YP_001271315.1 PFAM: peptidase U34, dipeptidase YP_001271316.1 PFAM: Malate/L-lactate dehydrogenase YP_001271317.1 TIGRFAM: L-lactate dehydrogenase; PFAM: Lactate/malate dehydrogenase YP_001271319.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_001271320.1 PFAM: protein of unknown function DUF558 YP_001271322.1 TIGRFAM: RelA/SpoT family protein; PFAM: TGS domain protein; metal-dependent phosphohydrolase, HD sub domain; RelA/SpoT domain protein; SMART: metal-dependent phosphohydrolase, HD region YP_001271323.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_001271324.1 PFAM: aminoglycoside phosphotransferase; fructosamine kinase YP_001271325.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001271326.1 PFAM: transposase IS200-family protein YP_001271327.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001271328.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; extracellular solute-binding protein, family 3 YP_001271329.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_001271330.1 PFAM: GatB/Yqey domain protein YP_001271331.1 PFAM: Choloylglycine hydrolase YP_001271332.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_001271333.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_001271334.1 PFAM: BioY protein YP_001271335.1 TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin protein ligase domain protein; biotin/lipoate A/B protein ligase; Helix-turn-helix, type 11 domain protein YP_001271336.1 PFAM: PhoH family protein YP_001271337.1 PFAM: protein of unknown function UPF0054 YP_001271338.1 PFAM: diacylglycerol kinase YP_001271339.1 TIGRFAM: small GTP-binding protein; GTP-binding protein Era; PFAM: GTP-binding protein, HSR1-related; KH, type 2 domain protein; Miro domain protein YP_001271340.1 TIGRFAM: DNA repair protein RecO; PFAM: Recombination protein O, RecO YP_001271341.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001271342.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001271343.1 TIGRFAM: DNA primase; PFAM: zinc finger, CHC2-family protein; TOPRIM domain protein; DNA primase catalytic core, N-terminal domain; SMART: Toprim sub domain protein YP_001271344.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium YP_001271345.1 PFAM: aminotransferase, class I and II YP_001271347.1 PFAM: protein of unknown function DUF633 YP_001271348.1 PFAM: protein of unknown function DUF34 YP_001271349.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_001271351.1 TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP C-terminal domain protein; nucleic acid binding, OB-fold, tRNA/helicase-type; SMART: phosphoesterase PHP domain protein YP_001271352.1 TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta YP_001271354.1 PFAM: phage integrase family protein; phage integrase domain protein SAM domain protein YP_001271356.1 PFAM: chromosome segregation and condensation protein ScpA YP_001271357.1 TIGRFAM: segregation and condensation protein B; PFAM: chromosome segregation and condensation protein ScpB YP_001271358.1 PFAM: RNA-binding S4 domain protein; pseudouridine synthase YP_001271361.1 TIGRFAM: ATP-dependent DNA helicase, RecQ family; PFAM: helicase domain protein; type III restriction protein, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001271363.1 TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region YP_001271364.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_001271365.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001271366.1 PFAM: histone family protein DNA-binding protein YP_001271367.1 PFAM: TPR repeat-containing protein; SMART: Tetratricopeptide domain protein YP_001271368.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity YP_001271369.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001271370.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_001271371.1 PFAM: dihydrofolate reductase region YP_001271372.1 TIGRFAM: channel protein, hemolysin III family; PFAM: Hly-III family protein YP_001271373.1 TIGRFAM: degV family protein; PFAM: DegV family protein YP_001271374.1 PFAM: lipolytic protein, G-D-S-L family YP_001271376.1 PFAM: protein of unknown function DUF1250 YP_001271377.1 PFAM: GTP-binding protein, HSR1-related YP_001271378.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001271379.1 TIGRFAM: DNA protecting protein DprA; PFAM: SMF family protein YP_001271380.1 TIGRFAM: DNA topoisomerase I; PFAM: TOPRIM domain protein; DNA topoisomerase, type IA, central domain protein; DNA topoisomerase, type IA, zn finger domain protein; SMART: DNA topoisomerase I, ATP-binding; DNA topoisomerase I, DNA-binding; Toprim sub domain protein YP_001271381.1 PFAM: Aldose 1-epimerase YP_001271382.1 PFAM: protein of unknown function DUF205 YP_001271383.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001271384.1 TIGRFAM: DNA topoisomerase IV, A subunit; PFAM: DNA gyrase/topoisomerase IV, subunit A; DNA gyrase C-terminal repeat, beta-propeller YP_001271385.1 PFAM: NUDIX hydrolase YP_001271386.1 PFAM: phosphoesterase, RecJ domain protein; DHHA2 domain protein YP_001271387.1 PFAM: Integrase, catalytic region YP_001271389.1 PFAM: GCN5-related N-acetyltransferase YP_001271390.1 PFAM: protein of unknown function DUF322 YP_001271393.1 PFAM: carbohydrate kinase, FGGY YP_001271394.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001271395.1 TIGRFAM: gluconate transporter; PFAM: Gluconate transporter YP_001271396.1 PFAM: Resolvase, N-terminal domain; Recombinase YP_001271401.1 PFAM: helix-turn-helix domain protein YP_001271402.1 PFAM: helix-turn-helix domain protein YP_001271403.1 PFAM: BRO domain protein domain protein; phage antirepressor protein YP_001271407.1 PFAM: helix-turn-helix domain protein YP_001271410.1 SMART: helix-turn-helix domain protein YP_001271411.1 PFAM: RecT protein YP_001271413.1 TIGRFAM: primosome, DnaD subunit YP_001271429.1 PFAM: phosphoadenosine phosphosulfate reductase YP_001271431.1 SMART: ParB domain protein nuclease YP_001271433.1 TIGRFAM: phage terminase, large subunit, PBSX family; PFAM: phage terminase large subunit; protein of unknown function DUF1545 YP_001271434.1 TIGRFAM: phage portal protein, SPP1 family; PFAM: phage portal protein, SPP1 YP_001271435.1 TIGRFAM: phage head morphogenesis protein, SPP1 gp7 family YP_001271446.1 PFAM: TMP repeat-containing protein; Lytic transglycosylase, catalytic YP_001271447.1 PFAM: protein of unknown function DUF1306 YP_001271448.1 PFAM: peptidase M23B YP_001271452.1 PFAM: lipolytic protein, G-D-S-L family YP_001271458.1 TIGRFAM: toxin secretion/phage lysis holin; PFAM: Holin, toxin secretion/phage lysis YP_001271459.1 PFAM: N-acetylmuramoyl-L-alanine amidase, family 2 YP_001271461.1 PFAM: carbohydrate kinase, FGGY YP_001271462.1 PFAM: GCN5-related N-acetyltransferase YP_001271466.1 TIGRFAM: LPXTG-motif cell wall anchor domain; PFAM: Amidase; surface protein from Gram-positive cocci, anchor region YP_001271468.1 PFAM: protein of unknown function DUF805 YP_001271469.1 PFAM: N-6 DNA methylase YP_001271470.1 PFAM: restriction modification system DNA specificity domain YP_001271471.1 PFAM: restriction modification system DNA specificity domain YP_001271472.1 PFAM: phage integrase family protein YP_001271473.1 PFAM: restriction modification system DNA specificity domain YP_001271474.1 TIGRFAM: type I site-specific deoxyribonuclease, HsdR family; PFAM: type III restriction protein, res subunit; protein of unknown function DUF450; SMART: DEAD-like helicases-like YP_001271477.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific YP_001271478.1 TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: CMP/dCMP deaminase, zinc-binding; bifunctional deaminase-reductase domain protein YP_001271479.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_001271480.1 PFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase; GTP cyclohydrolase II YP_001271481.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_001271482.1 PFAM: Ion transport protein; Ion transport 2 domain protein YP_001271484.1 PFAM: major facilitator superfamily MFS_1 YP_001271485.1 TIGRFAM: RNA polymerase sigma-70 YP_001271486.1 PFAM: thioesterase superfamily protein YP_001271487.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_001271488.1 TIGRFAM: O-succinylbenzoate-CoA ligase; PFAM: AMP-dependent synthetase and ligase YP_001271490.1 TIGRFAM: ferrous iron transport protein B; PFAM: GTP-binding protein, HSR1-related; Ferrous iron transport protein B domain protein; Ferrous iron transport B domain protein; nucleoside recognition domain protein YP_001271491.1 TIGRFAM: FeS assembly ATPase SufC; PFAM: ABC transporter related; SMART: AAA ATPase YP_001271492.1 TIGRFAM: FeS assembly protein SufD; PFAM: SufBD protein YP_001271493.1 TIGRFAM: cysteine desulfurase, SufS subfamily; PFAM: aminotransferase, class V; aromatic amino acid beta-eliminating lyase/threonine aldolase YP_001271494.1 TIGRFAM: SUF system FeS assembly protein, NifU family; PFAM: nitrogen-fixing NifU domain protein YP_001271495.1 TIGRFAM: FeS assembly protein SufB; PFAM: SufBD protein YP_001271496.1 PFAM: protein of unknown function DUF59 YP_001271497.1 PFAM: helix-turn-helix domain protein YP_001271498.1 PFAM: regulatory protein, LuxR; response regulator receiver YP_001271499.1 PFAM: cytochrome b5 YP_001271500.1 TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase, type 3 YP_001271501.1 PFAM: Fmu (Sun) domain protein YP_001271502.1 PFAM: band 7 protein YP_001271503.1 PFAM: GAF domain protein; ATP-binding region, ATPase domain protein domain protein; histidine kinase internal region; 5TM Receptors of the LytS-YhcK type, transmembrane region YP_001271504.1 PFAM: response regulator receiver; LytTr DNA-binding region YP_001271505.1 PFAM: LrgA family protein YP_001271506.1 PFAM: LrgB family protein YP_001271507.1 TIGRFAM: L-lactate dehydrogenase; PFAM: Lactate/malate dehydrogenase YP_001271508.1 PFAM: regulatory protein, LacI YP_001271509.1 PFAM: glycoside hydrolase, clan GH-D YP_001271510.1 PFAM: protein of unknown function DUF1440 YP_001271511.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate YP_001271512.1 TIGRFAM: phosphomevalonate kinase; PFAM: GHMP kinase; GHMP kinase, C terminal domain protein YP_001271513.1 TIGRFAM: diphosphomevalonate decarboxylase; PFAM: GHMP kinase; GHMP kinase, C terminal domain protein YP_001271514.1 TIGRFAM: mevalonate kinase; PFAM: GHMP kinase; GHMP kinase, C terminal domain protein YP_001271515.1 TIGRFAM: DNA polymerase III, epsilon subunit; DnaQ family exonuclease/DinG family helicase, putative; PFAM: helicase domain protein; Exonuclease, RNase T and DNA polymerase III; SMART: Exonuclease; helicase c2; DEAD-like helicases-like YP_001271517.1 TIGRFAM: primosome, DnaD subunit; PFAM: DnaD and phage-associated region YP_001271518.1 PFAM: protein of unknown function DUF6, transmembrane YP_001271519.1 TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase, family 51; penicillin-binding protein, transpeptidase YP_001271520.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC YP_001271521.1 PFAM: protein of unknown function DUF1273 YP_001271522.1 GpsB; guiding PBP1 shuttling; similar to DivIVA YP_001271523.1 PFAM: NrdI family protein YP_001271524.1 PFAM: RNA methylase YP_001271527.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001271528.1 TIGRFAM: pseudouridine synthase, RluA family; PFAM: RNA-binding S4 domain protein; pseudouridine synthase YP_001271529.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001271530.1 PFAM: Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation YP_001271531.1 PFAM: protein of unknown function DUF814; Fibronectin-binding A domain protein YP_001271532.1 TIGRFAM: degV family protein; PFAM: DegV family protein YP_001271534.1 PFAM: metal-dependent phosphohydrolase, HD sub domain YP_001271535.1 PFAM: glycosyl transferase, family 8 YP_001271536.1 PFAM: hydrolase family protein YP_001271537.1 PFAM: GCN5-related N-acetyltransferase YP_001271538.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein YP_001271539.1 PFAM: protein of unknown function DUF711 YP_001271540.1 PFAM: amino acid-binding ACT domain protein YP_001271541.1 PFAM: aldo/keto reductase YP_001271542.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001271545.1 PFAM: protein of unknown function DUF441 YP_001271546.1 TIGRFAM: drug resistance transporter, EmrB/QacA subfamily; PFAM: major facilitator superfamily MFS_1 YP_001271547.1 TIGRFAM: Copper transport repressor CopY/TcrY; PFAM: Penicillinase repressor YP_001271548.1 PFAM: CBS domain containing protein; protein of unknown function DUF21; transporter-associated region YP_001271549.1 PFAM: ABC-1 domain protein YP_001271550.1 PFAM: protein of unknown function DUF218 YP_001271551.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase YP_001271552.1 PFAM: Camphor resistance CrcB protein YP_001271553.1 TIGRFAM: CrcB protein; PFAM: Camphor resistance CrcB protein YP_001271554.1 PFAM: ABC transporter related YP_001271555.1 PFAM: SNARE associated Golgi protein YP_001271557.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001271558.1 TIGRFAM: LPXTG-motif cell wall anchor domain YP_001271559.1 PFAM: amino acid permease-associated region YP_001271560.1 PFAM: DNA/RNA non-specific endonuclease YP_001271562.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein YP_001271566.1 PFAM: protein of unknown function DUF421 YP_001271567.1 PFAM: hydrolase family protein YP_001271569.1 PFAM: nucleoside 2-deoxyribosyltransferase YP_001271570.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IIB; PFAM: sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase, type 3 YP_001271575.1 PFAM: transposase IS200-family protein YP_001271576.1 PFAM: Alpha/beta hydrolase fold-3 domain protein YP_001271577.1 PFAM: DSBA oxidoreductase YP_001271579.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_001271580.1 PFAM: acetyl-CoA carboxylase, alpha subunit YP_001271581.1 TIGRFAM: acetyl-CoA carboxylase, carboxyl transferase, beta subunit YP_001271582.1 TIGRFAM: acetyl-CoA carboxylase, biotin carboxylase; PFAM: Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein YP_001271583.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_001271584.1 PFAM: biotin/lipoyl attachment domain-containing protein YP_001271585.1 PFAM: Beta-ketoacyl synthase-like YP_001271586.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR YP_001271588.1 carries the fatty acid chain in fatty acid biosynthesis YP_001271589.1 TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) synthase III; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III YP_001271590.1 PFAM: regulatory protein, MarR YP_001271591.1 TIGRFAM: beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; PFAM: Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ YP_001271592.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS YP_001271593.1 PFAM: Integrase, catalytic region YP_001271595.1 PFAM: Patatin YP_001271596.1 PFAM: phage integrase family protein YP_001271597.1 PFAM: protein of unknown function DUF6, transmembrane YP_001271598.1 PFAM: transposase, IS4 family protein YP_001271599.1 PFAM: Integrase, catalytic region YP_001271601.1 PFAM: transposase IS200-family protein YP_001271604.1 PFAM: regulatory protein, Crp YP_001271606.1 PFAM: IS66 Orf2 family protein YP_001271607.1 PFAM: transposase IS66 YP_001271610.1 PFAM: hydroxyethylthiazole kinase YP_001271611.1 TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1 YP_001271612.1 TIGRFAM: thiamine-phosphate pyrophosphorylase; PFAM: thiamine monophosphate synthase YP_001271613.1 PFAM: Chloride channel, core YP_001271614.1 PFAM: glycoside hydrolase, family 31 YP_001271615.1 PFAM: phosphoesterase, PA-phosphatase related YP_001271617.1 PFAM: IS66 Orf2 family protein YP_001271618.1 PFAM: transposase IS66 YP_001271622.1 PFAM: Phosphoglycerate mutase YP_001271623.1 PFAM: glucosamine/galactosamine-6-phosphate isomerase YP_001271624.1 PFAM: filamentation induced by cAMP protein Fic YP_001271626.1 TIGRFAM: LPXTG-motif cell wall anchor domain; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein YP_001271628.1 PFAM: SMC domain protein YP_001271629.1 TIGRFAM: nuclease SbcCD, D subunit; PFAM: metallophosphoesterase YP_001271631.1 PFAM: PHP C-terminal domain protein YP_001271632.1 PFAM: helicase domain protein YP_001271633.1 PFAM: zinc finger, SWIM domain protein; SNF2 helicase associated domain protein; SMART: DEAD-like helicases-like YP_001271636.1 PFAM: helix-turn-helix domain protein YP_001271638.1 PFAM: amino acid permease-associated region YP_001271639.1 converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines YP_001271641.1 PFAM: Integrase, catalytic region YP_001271643.1 PFAM: IstB domain protein ATP-binding protein; SMART: AAA ATPase YP_001271644.1 PFAM: Integrase, catalytic region YP_001271646.1 SMART: AAA ATPase YP_001271648.1 PFAM: KAP P-loop domain protein YP_001271650.1 PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain YP_001271651.1 PFAM: NAD-dependent epimerase/dehydratase; Male sterility C-terminal domain YP_001271652.1 TIGRFAM: cell envelope-related function transcriptional attenuator, LytR/CpsA family; PFAM: cell envelope-related transcriptional attenuator YP_001271653.1 PFAM: helix-turn-helix, HxlR type YP_001271655.1 PFAM: transposase IS200-family protein YP_001271659.1 TIGRFAM: glycerol kinase; PFAM: carbohydrate kinase, FGGY YP_001271660.1 PFAM: 4-oxalocrotonate tautomerase YP_001271661.1 PFAM: TrkA-N domain protein; TrkA-C domain protein; sodium/hydrogen exchanger YP_001271662.1 PFAM: peptidase U34, dipeptidase YP_001271664.1 PFAM: Integrase, catalytic region YP_001271665.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001271666.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein YP_001271667.1 TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: serine dehydratase alpha chain YP_001271668.1 PFAM: serine dehydratase beta chain YP_001271671.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_001271672.1 PFAM: metallophosphoesterase YP_001271673.1 PFAM: major facilitator superfamily MFS_1 YP_001271674.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_001271675.1 PFAM: Methionine synthase, vitamin-B12 independent; Cobalamin-independent synthase MetE, N-terminal domain protein YP_001271676.1 PFAM: cyclase family protein YP_001271677.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_001271678.1 PFAM: Polyprenyl synthetase YP_001271679.1 PFAM: Glycoside hydrolase, family 42, N-terminal domain protein; Beta-galactosidase trimerisation domain protein YP_001271680.1 TIGRFAM: PTS system, glucose subfamily, IIA subunit; sugar (Glycoside-Pentoside-Hexuronide) transporter; PFAM: sugar-specific permease, EIIA 1 domain YP_001271681.1 PFAM: regulatory protein, LacI YP_001271683.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein YP_001271684.1 TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase YP_001271687.1 PFAM: transposase IS200-family protein YP_001271688.1 PFAM: N-acetylmuramoyl-L-alanine amidase, family 2 YP_001271695.1 PFAM: lipolytic protein, G-D-S-L family YP_001271699.1 PFAM: NLP/P60 protein YP_001271700.1 PFAM: protein of unknown function DUF1306 YP_001271701.1 TIGRFAM: phage tape measure protein; PFAM: Lytic transglycosylase, catalytic YP_001271703.1 PFAM: phage major tail protein YP_001271704.1 PFAM: protein of unknown function DUF806 YP_001271705.1 TIGRFAM: phage protein, HK97 gp10 family; PFAM: protein of unknown function DUF646, phage head/tail component YP_001271706.1 TIGRFAM: phage head-tail adaptor, putative; PFAM: phage head-tail joining family protein YP_001271707.1 TIGRFAM: uncharacterized phage protein (possible DNA packaging); PFAM: Uncharacterized phage protein (possible DNA packaging) YP_001271708.1 TIGRFAM: phage major capsid protein, HK97 family; PFAM: phage major capsid protein, HK97 YP_001271709.1 PFAM: peptidase S14, ClpP YP_001271710.1 TIGRFAM: phage portal protein, HK97 family; PFAM: phage portal protein YP_001271711.1 PFAM: phage Terminase YP_001271714.1 TIGRFAM: phage terminase, small subunit, putative, P27 family; PFAM: phage terminase, small subunit, putative, P27 YP_001271715.1 PFAM: HNH endonuclease; SMART: HNH nuclease YP_001271717.1 PFAM: transposase IS200-family protein YP_001271731.1 TIGRFAM: primosome, DnaD subunit YP_001271733.1 PFAM: RecT protein YP_001271736.1 PFAM: BRO domain protein domain protein; phage antirepressor protein YP_001271737.1 SMART: helix-turn-helix domain protein YP_001271738.1 PFAM: helix-turn-helix domain protein YP_001271739.1 PFAM: protein of unknown function DUF955 YP_001271740.1 PFAM: protein of unknown function DUF1535 YP_001271742.1 PFAM: phage integrase family protein YP_001271743.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001271744.1 PFAM: amino acid permease-associated region YP_001271745.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_001271746.1 Essential for efficient processing of 16S rRNA YP_001271748.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001271749.1 TIGRFAM: signal recognition particle protein; PFAM: GTP-binding signal recognition particle SRP54, G- domain; Signal peptide binding (SRP54) M- domain protein; GTP-binding signal recognition particle SRP54, helical bundle; SMART: AAA ATPase YP_001271750.1 PFAM: helix-turn-helix protein, YlxM/p13 family protein YP_001271751.1 TIGRFAM: signal recognition particle-docking protein FtsY; PFAM: GTP-binding signal recognition particle SRP54, G- domain; GTP-binding signal recognition particle SRP54, helical bundle; SMART: AAA ATPase YP_001271752.1 TIGRFAM: chromosome segregation protein SMC; PFAM: SMC domain protein; SMCs flexible hinge domain protein YP_001271753.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_001271754.1 carries the fatty acid chain in fatty acid biosynthesis YP_001271755.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_001271756.1 catalyzes branch migration in Holliday junction intermediates YP_001271757.1 PFAM: Dak phosphatase YP_001271758.1 PFAM: protein of unknown function DUF322 YP_001271759.1 required for 70S ribosome assembly YP_001271760.1 TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase, catalytic region YP_001271761.1 PFAM: ribulose-phosphate 3-epimerase YP_001271762.1 TIGRFAM: ribosome small subunit-dependent GTPase A; PFAM: GTPase EngC YP_001271763.1 PFAM: protein kinase; PASTA domain containing protein; SMART: tyrosine protein kinase; serine/threonine protein kinase YP_001271764.1 PFAM: Protein phosphatase 2C-like; SMART: protein phosphatase 2C domain protein YP_001271765.1 TIGRFAM: sun protein; PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44 YP_001271766.1 TIGRFAM: methionyl-tRNA formyltransferase; PFAM: formyl transferase domain protein YP_001271767.1 TIGRFAM: primosomal protein N'; PFAM: helicase domain protein; type III restriction protein, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001271768.1 TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; PFAM: flavoprotein; DNA/pantothenate metabolism flavoprotein domain protein YP_001271769.1 TIGRFAM: DNA-directed RNA polymerase, omega subunit; PFAM: RNA polymerase Rpb6 YP_001271770.1 Essential for recycling GMP and indirectly, cGMP YP_001271772.1 TIGRFAM: DNA repair protein RecN; PFAM: SMC domain protein YP_001271773.1 PFAM: arginine repressor YP_001271774.1 TIGRFAM: hemolysin A; PFAM: ribosomal RNA methyltransferase RrmJ/FtsJ; RNA-binding S4 domain protein YP_001271775.1 PFAM: Polyprenyl synthetase YP_001271776.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_001271777.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_001271778.1 PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase YP_001271779.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_001271780.1 PFAM: protein of unknown function DUF322 YP_001271782.1 PFAM: creatinase; peptidase M24 YP_001271783.1 PFAM: alanine racemase domain protein YP_001271784.1 involved in the peptidyltransferase reaction during translation YP_001271785.1 PFAM: protein of unknown function DUF464 YP_001271786.1 PFAM: ribosomal protein L21 YP_001271787.1 PFAM: regulatory protein, TetR YP_001271791.1 PFAM: protein of unknown function DUF59 YP_001271792.1 TIGRFAM: peptide methionine sulfoxide reductase; PFAM: Methionine sulfoxide reductase A YP_001271793.1 PFAM: NLPA lipoprotein YP_001271794.1 PFAM: aminotransferase, class I and II YP_001271795.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001271796.1 TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp YP_001271797.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_001271799.1 PFAM: Rhodanese domain protein YP_001271800.1 TIGRFAM: glucokinase, ROK family; PFAM: ROK family protein YP_001271801.1 PFAM: protein of unknown function DUF910 YP_001271802.1 PFAM: Rhomboid family protein YP_001271803.1 PFAM: 5-formyltetrahydrofolate cyclo-ligase YP_001271804.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001271805.1 PFAM: penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain YP_001271807.1 PFAM: HesB/YadR/YfhF-family protein YP_001271808.1 TIGRFAM: transcription elongation factor GreA; PFAM: transcription elongation factor GreA/GreB domain protein YP_001271809.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_001271810.1 PFAM: NLP/P60 protein; Peptidoglycan-binding LysM YP_001271811.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001271812.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001271813.1 PFAM: helix-turn-helix, HxlR type YP_001271814.1 PFAM: metal-dependent phosphohydrolase, HD sub domain YP_001271815.1 PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase, substrate binding YP_001271816.1 PFAM: acylphosphatase YP_001271817.1 PFAM: 60 kDa inner membrane insertion protein YP_001271818.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001271819.1 PFAM: multi antimicrobial extrusion protein MatE YP_001271820.1 PFAM: amino acid permease-associated region YP_001271821.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein YP_001271822.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001271823.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_001271824.1 PFAM: protein of unknown function DUF177 YP_001271825.1 PFAM: protein of unknown function DUF795 YP_001271826.1 PFAM: Methyltransferase type 11; Methyltransferase type 12 YP_001271827.1 TIGRFAM: iojap-like protein; PFAM: Iojap-related protein YP_001271828.1 TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001271829.1 TIGRFAM: cytidyltransferase-related domain; nicotinate (nicotinamide) nucleotide adenylyltransferase; PFAM: cytidylyltransferase YP_001271830.1 PFAM: protein of unknown function UPF0044 YP_001271831.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis YP_001271832.1 TIGRFAM: hydrolase, HAD-superfamily, subfamily IIIA; HAD superfamily (subfamily IIIA) phosphatase, TIGR01668 YP_001271833.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001271834.1 PFAM: ribosomal protein L35 YP_001271835.1 TIGRFAM: translation initiation factor IF-3; PFAM: initiation factor 3 YP_001271836.1 PFAM: Primosomal DnaI domain protein YP_001271837.1 PFAM: replication initiation and membrane attachment family protein YP_001271838.1 PFAM: ATP-cone domain protein YP_001271839.1 TIGRFAM: dephospho-CoA kinase; PFAM: Dephospho-CoA kinase YP_001271840.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_001271841.1 TIGRFAM: DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease; SMART: 3'-5' exonuclease; Helix-hairpin-helix domain protein, class 2 YP_001271842.1 PFAM: protein of unknown function DUF1275 YP_001271843.1 PFAM: protein of unknown function UPF0005 YP_001271844.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001271845.1 PFAM: t-RNA-binding domain protein YP_001271846.1 PFAM: Thioredoxin domain YP_001271848.1 PFAM: glutaminase YP_001271849.1 PFAM: aldo/keto reductase YP_001271850.1 PFAM: glycosyl transferase, group 1; Protein of unknown function DUF1975 YP_001271851.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein YP_001271852.1 TIGRFAM: LPXTG-motif cell wall anchor domain; PFAM: surface protein from Gram-positive cocci, anchor region; PT repeat-containing protein YP_001271853.1 PFAM: YSIRK Gram-positive signal peptide YP_001271854.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_001271855.1 PFAM: ABC transporter EcsB YP_001271856.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001271857.1 PFAM: histidine triad (HIT) protein YP_001271859.1 PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase YP_001271861.1 PFAM: metallophosphoesterase YP_001271862.1 PFAM: protein of unknown function DUF964 YP_001271863.1 TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase, family 51; penicillin-binding protein, transpeptidase YP_001271864.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001271865.1 TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1 YP_001271866.1 TIGRFAM: L-lactate dehydrogenase; PFAM: Lactate/malate dehydrogenase YP_001271869.1 TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase, DHPS YP_001271870.1 PFAM: Ham1 family protein YP_001271871.1 TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase, middle domain protein YP_001271872.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_001271873.1 TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK YP_001271874.1 TIGRFAM: dihydroneopterin aldolase YP_001271877.1 PFAM: Abortive infection protein YP_001271879.1 TIGRFAM: ribokinase; PFAM: PfkB domain protein YP_001271880.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001271882.1 PFAM: deoxynucleoside kinase YP_001271883.1 PFAM: Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase; SMART: Lysozyme subfamily 2 YP_001271884.1 PFAM: UspA domain protein YP_001271885.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases YP_001271886.1 TIGRFAM: carbohydrate kinase, YjeF related protein; PFAM: protein of unknown function UPF0031 YP_001271887.1 PFAM: polysaccharide biosynthesis protein YP_001271888.1 PFAM: protein of unknown function UPF0150 YP_001271889.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001271890.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001271891.1 PFAM: methyladenine glycosylase YP_001271893.1 PFAM: major facilitator superfamily MFS_1 YP_001271894.1 PFAM: ferric-uptake regulator YP_001271895.1 PFAM: amino acid permease-associated region YP_001271896.1 PFAM: VanZ family protein YP_001271900.1 PFAM: UMUC domain protein DNA-repair protein YP_001271901.1 PFAM: heat shock protein Hsp20 YP_001271902.1 PFAM: aldo/keto reductase YP_001271903.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines YP_001271904.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain YP_001271905.1 TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase YP_001271906.1 PFAM: Peptidoglycan-binding LysM YP_001271908.1 PFAM: Peptidoglycan-binding LysM YP_001271910.1 TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein YP_001271911.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_001271912.1 TIGRFAM: drug resistance transporter, EmrB/QacA subfamily; PFAM: major facilitator superfamily MFS_1 YP_001271913.1 PFAM: GCN5-related N-acetyltransferase YP_001271915.1 PFAM: conserved hypothetical protein 374 YP_001271916.1 PFAM: glycosyl transferase, group 1 YP_001271917.1 PFAM: glycosyl transferase, group 1 YP_001271918.1 TIGRFAM: phosphoenolpyruvate-protein phosphotransferase; PFAM: PEP-utilizing protein; PEP-utilising protein, mobile region; PEP-utilising protein domain protein YP_001271919.1 TIGRFAM: phosphocarrier, HPr family; PFAM: phosphocarrier HPr protein YP_001271921.1 PFAM: UvrB/UvrC protein; AAA ATPase, central domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase YP_001271925.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001271926.1 PFAM: regulatory protein GntR, HTH YP_001271928.1 PFAM: glycosyl hydrolase 53 domain protein YP_001271929.1 PFAM: cell wall binding repeat-containing protein YP_001271930.1 PFAM: Integrase, catalytic region YP_001271932.1 PFAM: transposase IS3/IS911 family protein YP_001271934.1 PFAM: cell wall binding repeat-containing protein; glycoside hydrolase, family 70 YP_001271935.1 PFAM: NLP/P60 protein; cell wall binding repeat-containing protein YP_001271936.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein YP_001271937.1 PFAM: transposase IS200-family protein YP_001271938.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_001271939.1 TIGRFAM: cell envelope-related function transcriptional attenuator, LytR/CpsA family; PFAM: cell envelope-related transcriptional attenuator YP_001271941.1 PFAM: protein of unknown function UPF0118 YP_001271946.1 PFAM: IstB domain protein ATP-binding protein; SMART: AAA ATPase YP_001271947.1 PFAM: Integrase, catalytic region YP_001271948.1 PFAM: glycosyl transferase, family 2 YP_001271950.1 PFAM: NLP/P60 protein YP_001271951.1 PFAM: N-acetylmuramoyl-L-alanine amidase, family 2 YP_001271952.1 PFAM: transposase IS200-family protein YP_001271953.1 PFAM: Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase; SMART: Lysozyme subfamily 2 YP_001271954.1 PFAM: acyltransferase 3 YP_001271956.1 PFAM: glycosyl transferase, group 1 YP_001271957.1 PFAM: polysaccharide biosynthesis protein; virulence factor MVIN family protein YP_001271958.1 PFAM: lipopolysaccharide biosynthesis protein YP_001271960.1 PFAM: UDP-galactopyranose mutase YP_001271961.1 PFAM: sugar transferase YP_001271962.1 PFAM: glycosyl transferase, family 2 YP_001271964.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_001271967.1 TIGRFAM: ribonuclease BN; PFAM: ribonuclease BN YP_001271968.1 PFAM: amino acid permease-associated region YP_001271969.1 PFAM: amino acid permease-associated region YP_001271970.1 associated with arginine deiminase pathway genes; probably functions in arginine catabolism YP_001271971.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_001271972.1 TIGRFAM: flavodoxin; PFAM: flavodoxin/nitric oxide synthase YP_001271973.1 PFAM: GtrA family protein YP_001271975.1 PFAM: UDP-N-acetylglucosamine 2-epimerase YP_001271976.1 PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001271977.1 PFAM: oxidoreductase domain protein YP_001271979.1 PFAM: conserved hypothetical protein 730 YP_001271980.1 PFAM: Lactate/malate dehydrogenase YP_001271983.1 PFAM: GCN5-related N-acetyltransferase YP_001271984.1 PFAM: protein of unknown function UPF0005 YP_001271986.1 PFAM: GCN5-related N-acetyltransferase YP_001271987.1 PFAM: LytTr DNA-binding region YP_001271989.1 PFAM: N-acetylmuramoyl-L-alanine amidase, family 2 YP_001271991.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: transposase, IS605 OrfB YP_001271993.1 TIGRFAM: methylated-DNA--protein-cysteine methyltransferase; PFAM: Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding YP_001271994.1 PFAM: nitroreductase YP_001271996.1 PFAM: GCN5-related N-acetyltransferase YP_001271997.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001271998.1 TIGRFAM: ammonium transporter; PFAM: Rh family protein/ammonium transporter YP_001272002.1 PFAM: type III restriction protein, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001272004.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001272006.1 PFAM: LytTr DNA-binding region YP_001272008.1 PFAM: plasmid pRiA4b ORF-3 family protein YP_001272010.1 PFAM: cyclic nucleotide-binding; regulatory protein, Crp YP_001272012.1 PFAM: Heavy metal transport/detoxification protein YP_001272013.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein YP_001272014.1 PFAM: isochorismatase hydrolase YP_001272015.1 PFAM: helicase domain protein; type III restriction protein, res subunit; protein of unknown function DUF450; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001272016.1 PFAM: restriction modification system DNA specificity domain YP_001272017.1 PFAM: phage integrase family protein YP_001272018.1 PFAM: restriction modification system DNA specificity domain YP_001272019.1 PFAM: N-6 DNA methylase YP_001272021.1 TIGRFAM: RNA methyltransferase, TrmA family; PFAM: deoxyribonuclease/rho motif-related TRAM; protein of unknown function Met10; (Uracil-5)-methyltransferase YP_001272022.1 similar to YegS from E. coli YP_001272023.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001272024.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001272025.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_001272026.1 PFAM: CamS sex pheromone cAM373 family protein YP_001272027.1 TIGRFAM: DNA ligase, NAD-dependent; PFAM: BRCT domain protein; zinc-finger, NAD-dependent DNA ligase C4-type; NAD-dependent DNA ligase, OB-fold; NAD-dependent DNA ligase, adenylation; SMART: NAD-dependent DNA ligase-like YP_001272028.1 TIGRFAM: ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase YP_001272029.1 PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp YP_001272030.1 TIGRFAM: xanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase YP_001272031.1 PFAM: Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase; SMART: Lysozyme subfamily 2 YP_001272032.1 TIGRFAM: acetoin reductase; PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001272033.1 PFAM: ribosomal protein S9 YP_001272034.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001272035.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001272036.1 PFAM: cobalt transport protein YP_001272037.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001272038.1 PFAM: SMC domain protein; ABC transporter related; SMART: AAA ATPase YP_001272039.1 is a component of the macrolide binding site in the peptidyl transferase center YP_001272040.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001272041.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001272042.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_001272043.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_001272044.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001272045.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_001272046.1 TIGRFAM: preprotein translocase, SecY subunit; PFAM: SecY protein YP_001272047.1 late assembly protein YP_001272048.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001272049.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001272050.1 binds 5S rRNA along with protein L5 and L25 YP_001272051.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001272052.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001272053.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif YP_001272054.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001272055.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001272056.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_001272057.1 PFAM: ribosomal protein S17 YP_001272058.1 one of the stabilizing components for the large ribosomal subunit YP_001272059.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001272060.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_001272061.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001272062.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001272063.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001272064.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001272065.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001272066.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001272067.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_001272068.1 PFAM: transposase, IS204/IS1001/IS1096/IS1165 family protein YP_001272069.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001272070.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001272071.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_001272072.1 PFAM: peptidase A24A, prepilin type IV; peptidase A24A domain protein YP_001272074.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001272075.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001272076.1 PFAM: regulatory protein, TetR YP_001272077.1 PFAM: UvrB/UvrC protein; AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase YP_001272078.1 PFAM: Firmicute transcriptional repressor of class III stress genes YP_001272079.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs YP_001272080.1 PFAM: deoxynucleoside kinase YP_001272081.1 PFAM: transposase IS200-family protein YP_001272082.1 PFAM: amino acid permease-associated region YP_001272083.1 PFAM: GCN5-related N-acetyltransferase YP_001272084.1 PFAM: phosphoesterase, PA-phosphatase related YP_001272086.1 PFAM: protein of unknown function DUF1212 YP_001272087.1 PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein YP_001272088.1 PFAM: iron dependent repressor; FeoA family protein YP_001272089.1 TIGRFAM: cation diffusion facilitator family transporter; PFAM: cation efflux protein YP_001272090.1 PFAM: protein of unknown function DUF125, transmembrane YP_001272091.1 PFAM: protein of unknown function DUF125, transmembrane YP_001272092.1 PFAM: UspA domain protein YP_001272093.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001272094.1 PFAM: extracellular solute-binding protein, family 3; SMART: ionotropic glutamate receptor YP_001272095.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component YP_001272096.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component YP_001272097.1 PFAM: Abortive infection protein YP_001272098.1 PFAM: beta-lactamase domain protein; RNA-metabolising metallo-beta-lactamase YP_001272100.1 PFAM: regulatory protein, MerR YP_001272101.1 TIGRFAM: drug resistance transporter, EmrB/QacA subfamily; PFAM: major facilitator superfamily MFS_1 YP_001272103.1 TIGRFAM: pseudouridine synthase, RluA family; PFAM: pseudouridine synthase YP_001272104.1 PFAM: protein of unknown function DUF470; protein of unknown function DUF471; protein of unknown function DUF472 YP_001272105.1 TIGRFAM: DJ-1 family protein; PFAM: ThiJ/PfpI domain protein YP_001272106.1 PFAM: Alpha/beta hydrolase fold-3 domain protein YP_001272107.1 PFAM: major facilitator superfamily MFS_1 YP_001272108.1 PFAM: Uracil-DNA glycosylase superfamily YP_001272109.1 PFAM: protein of unknown function DUF1212 YP_001272110.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001272111.1 TIGRFAM: anion transporter; PFAM: sodium/sulphate symporter; TRAP C4-dicarboxylate transport system permease DctM subunit YP_001272112.1 TIGRFAM: flavocytochrome c; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; HI0933 family protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001272113.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001272114.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_001272115.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001272116.1 PFAM: peptidyl-prolyl cis-trans isomerase, cyclophilin type YP_001272117.1 TIGRFAM: Alcohol dehydrogenase, zinc-binding type 2; PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001272118.1 PFAM: plasmid pRiA4b ORF-3 family protein YP_001272120.1 PFAM: Aldose 1-epimerase YP_001272122.1 PFAM: peptidase S11, D-alanyl-D-alanine carboxypeptidase 1 YP_001272123.1 PFAM: penicillin-binding protein, transpeptidase YP_001272124.1 PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001272125.1 PFAM: major facilitator superfamily MFS_1 YP_001272126.1 TIGRFAM: dipeptidase, putative; PFAM: peptidase M20 YP_001272127.1 PFAM: C4-dicarboxylate anaerobic carrier YP_001272128.1 TIGRFAM: Dyp-type peroxidase family; PFAM: Dyp-type peroxidase YP_001272129.1 PFAM: ABC transporter related YP_001272130.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001272132.1 PFAM: NAD(P)H dehydrogenase (quinone); NADPH-dependent FMN reductase YP_001272133.1 PFAM: Pyridoxal-5'-phosphate-dependent protein, beta subunit YP_001272134.1 PFAM: ferrochelatase YP_001272135.1 TIGRFAM: Mn2+/Fe2+ transporter, NRAMP family; PFAM: natural resistance-associated macrophage protein YP_001272136.1 PFAM: Methyltransferase type 11 YP_001272137.1 PFAM: TrkA-N domain protein; TrkA-C domain protein YP_001272138.1 PFAM: cation transporter YP_001272139.1 in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever YP_001272140.1 PFAM: nitroreductase YP_001272141.1 PFAM: glycoside hydrolase, family 8 YP_001272142.1 PFAM: glycosyl transferase, family 2 YP_001272144.1 TIGRFAM: phosphate transport system regulatory protein PhoU; PFAM: PhoU family protein YP_001272145.1 TIGRFAM: phosphate ABC transporter, ATPase subunit; PFAM: ABC transporter related; SMART: AAA ATPase YP_001272146.1 TIGRFAM: phosphate ABC transporter, inner membrane subunit PstA; PFAM: binding-protein-dependent transport systems inner membrane component YP_001272147.1 TIGRFAM: phosphate ABC transporter, inner membrane subunit PstC; PFAM: binding-protein-dependent transport systems inner membrane component YP_001272148.1 TIGRFAM: phosphate binding protein; PFAM: extracellular solute-binding protein, family 1 YP_001272149.1 PFAM: transcriptional regulator domain protein YP_001272153.1 PFAM: GCN5-related N-acetyltransferase YP_001272154.1 PFAM: mannose-6-phosphate isomerase, type I YP_001272156.1 PFAM: regulatory protein, LysR YP_001272157.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001272158.1 SMART: low molecular weight phosphotyrosine protein phosphatase YP_001272160.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001272162.1 PFAM: Integrase, catalytic region YP_001272163.1 PFAM: NLPA lipoprotein YP_001272164.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_001272165.1 PFAM: peptidase M10A and M12B, matrixin and adamalysin YP_001272167.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001272168.1 PFAM: transposase, IS204/IS1001/IS1096/IS1165 family protein YP_001272169.1 PFAM: Integrase, catalytic region YP_001272170.1 PFAM: transposase, IS204/IS1001/IS1096/IS1165 family protein YP_001272171.1 PFAM: cytochrome b5 YP_001272176.1 TIGRFAM: hydroxymethylpyrimidine transporter CytX; PFAM: permease for cytosine/purines, uracil, thiamine, allantoin YP_001272177.1 PFAM: GCN5-related N-acetyltransferase YP_001272179.1 PFAM: Peptidoglycan-binding LysM YP_001272180.1 PFAM: General substrate transporter; major facilitator superfamily MFS_1 YP_001272181.1 PFAM: conserved hypothetical protein 1440 YP_001272182.1 PFAM: tRNA/rRNA methyltransferase (SpoU) YP_001272183.1 PFAM: major facilitator superfamily MFS_1 YP_001272184.1 PFAM: phage integrase family protein YP_001272190.1 PFAM: glycoside hydrolase, family 13 domain protein Ig domain protein region domain protein; alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001272191.1 PFAM: major facilitator superfamily MFS_1 YP_001272194.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001272196.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_001272197.1 PFAM: sulfatase YP_001272198.1 PFAM: protein of unknown function DUF6, transmembrane YP_001272200.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001272201.1 PFAM: transposase IS200-family protein YP_001272203.1 PFAM: SNARE associated Golgi protein YP_001272204.1 PFAM: Phosphoglycerate mutase YP_001272205.1 PFAM: GTP-binding protein, HSR1-related YP_001272206.1 PFAM: Transglycosylase-associated protein YP_001272207.1 PFAM: CsbD family protein YP_001272208.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001272210.1 PFAM: regulatory protein, TetR YP_001272211.1 PFAM: PspC domain protein YP_001272214.1 PFAM: ferric-uptake regulator YP_001272215.1 PFAM: guanylate kinase; SMART: AAA ATPase; guanylate kinase/L-type calcium channel region YP_001272216.1 PFAM: NUDIX hydrolase YP_001272217.1 PFAM: amino acid permease-associated region YP_001272218.1 PFAM: General substrate transporter; major facilitator superfamily MFS_1 YP_001272220.1 PFAM: extracellular solute-binding protein, family 1 YP_001272221.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001272222.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001272223.1 TIGRFAM: spermidine/putrescine ABC transporter ATPase subunit; PFAM: ABC transporter related; Transport-associated OB domain protein; SMART: AAA ATPase YP_001272224.1 catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue YP_001272225.1 TIGRFAM: proline-specific peptidase; PFAM: alpha/beta hydrolase fold YP_001272226.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: cation transporting ATPase domain protein domain protein; Haloacid dehalogenase domain protein hydrolase; cation transporting ATPase domain protein; E1-E2 ATPase-associated domain protein YP_001272227.1 PFAM: Ferritin, Dps family protein YP_001272228.1 PFAM: amino acid permease-associated region YP_001272229.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001272232.1 PFAM: Integrase, catalytic region YP_001272233.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; HI0933 family protein YP_001272234.1 PFAM: Inosine/uridine-preferring nucleoside hydrolase YP_001272235.1 PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001272236.1 PFAM: protein of unknown function DUF81 YP_001272238.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001272239.1 PFAM: cobalt transport protein YP_001272241.1 PFAM: sodium/hydrogen exchanger YP_001272242.1 PFAM: protein of unknown function DUF1304 YP_001272244.1 PFAM: helix-turn-helix domain protein YP_001272246.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001272247.1 PFAM: PTS system Galactitol-specific IIC component YP_001272248.1 PFAM: General substrate transporter; major facilitator superfamily MFS_1 YP_001272249.1 PFAM: helix-turn-helix domain protein; ABC transporter related; SMART: AAA ATPase YP_001272253.1 TIGRFAM: lipoyltransferase and lipoate-protein ligase; PFAM: biotin/lipoate A/B protein ligase YP_001272254.1 PFAM: UspA domain protein YP_001272255.1 TIGRFAM: small GTP-binding protein; PFAM: elongation factor G domain protein; protein synthesis factor, GTP-binding YP_001272256.1 PFAM: ROK family protein YP_001272257.1 PFAM: branched-chain amino acid transport system II carrier protein YP_001272258.1 PFAM: transposase IS200-family protein YP_001272259.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001272261.1 PFAM: amino acid permease-associated region YP_001272262.1 PFAM: D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase YP_001272263.1 PFAM: regulatory protein GntR, HTH; UbiC transcription regulator-associated domain protein YP_001272264.1 TIGRFAM: ybaK/ebsC protein; PFAM: YbaK/prolyl-tRNA synthetase associated region YP_001272265.1 PFAM: peptidase U34, dipeptidase YP_001272266.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001272267.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001272268.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001272271.1 PFAM: Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase YP_001272273.1 PFAM: Phosphoglycerate mutase YP_001272274.1 PFAM: cobalamin-5-phosphate synthase CobS YP_001272275.1 PFAM: cobalbumin biosynthesis protein YP_001272276.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_001272277.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001272278.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_001272279.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_001272281.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation YP_001272282.1 TIGRFAM: cobalt ABC transporter, ATPase subunit; PFAM: ABC transporter related; SMART: AAA ATPase YP_001272283.1 TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein YP_001272284.1 PFAM: Cobalt transport protein CbiN YP_001272285.1 TIGRFAM: cobalamin biosynthesis protein CbiM; PFAM: cobalamin (vitamin B12) biosynthesis CbiM protein YP_001272286.1 catalyzes the formation of precorrin-3A from precorrin-2 YP_001272287.1 PFAM: anaerobic cobalt chelatase YP_001272288.1 TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001272289.1 TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK YP_001272290.1 TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001272291.1 PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein YP_001272292.1 TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001272293.1 catalyzes the methylation of either C-15 or C-5 in cobalt-precorrin-6Y to form cobalt-precorrin-7W; decarboxylating YP_001272294.1 catalyzes the methylation of C-5 in cobalt-precorrin-6Y to form cobalt-precorrin-7W-a YP_001272295.1 Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A YP_001272296.1 catalyzes the interconversion of cobalt-precorrin-8X and cobyrinic acid in the anaerobic biosynthesis of cobalamin YP_001272297.1 TIGRFAM: cobalamin biosynthesis protein CobD; PFAM: cobalamin biosynthesis protein CbiB YP_001272298.1 TIGRFAM: cobyrinic acid a,c-diamide synthase; PFAM: Cobyrinic acid a,c-diamide synthase; CobB/CobQ domain protein glutamine amidotransferase YP_001272299.1 TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II YP_001272300.1 PFAM: Integrase, catalytic region YP_001272301.1 TIGRFAM: ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase YP_001272302.1 PFAM: NADPH-dependent FMN reductase YP_001272303.1 PFAM: flavodoxin/nitric oxide synthase YP_001272304.1 TIGRFAM: ethanolamine utilization protein, EutP YP_001272306.1 PFAM: Phosphoglycerate mutase YP_001272308.1 PFAM: microcompartments protein YP_001272309.1 TIGRFAM: acetate kinase; PFAM: acetate and butyrate kinase YP_001272310.1 PFAM: iron-containing alcohol dehydrogenase YP_001272311.1 PFAM: aldehyde dehydrogenase YP_001272312.1 PFAM: protein of unknown function DUF336 YP_001272313.1 TIGRFAM: ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase YP_001272314.1 PFAM: Ethanolamine utilization protein EutN/carboxysome structural protein Ccml YP_001272316.1 PFAM: Propanediol utilization protein YP_001272317.1 PFAM: microcompartments protein YP_001272318.1 PFAM: microcompartments protein YP_001272320.1 PFAM: Diol/glycerol dehydratase reactivating factor, large subunit YP_001272321.1 PFAM: dehydratase, small subunit YP_001272322.1 PFAM: dehydratase, medium subunit YP_001272323.1 PFAM: dehydratase, large subunit YP_001272324.1 PFAM: microcompartments protein YP_001272325.1 PFAM: microcompartments protein YP_001272326.1 PFAM: helix-turn-helix- domain containing protein, AraC type YP_001272327.1 TIGRFAM: ethanolamine utilization protein EutJ family protein YP_001272328.1 PFAM: major intrinsic protein YP_001272330.1 PFAM: Xylose isomerase domain protein TIM barrel YP_001272331.1 PFAM: protein of unknown function UPF0118 YP_001272332.1 PFAM: B3/4 domain protein YP_001272333.1 PFAM: regulatory protein, MarR YP_001272334.1 PFAM: Domain of unknown function DUF1836 YP_001272337.1 PFAM: CBS domain containing protein; protein of unknown function DUF21; transporter-associated region YP_001272338.1 PFAM: NrdI family protein YP_001272339.1 PFAM: 3-demethylubiquinone-9 3-methyltransferase YP_001272340.1 PFAM: major facilitator superfamily MFS_1 YP_001272341.1 TIGRFAM: glucose-6-phosphate 1-dehydrogenase; PFAM: glucose-6-phosphate dehydrogenase YP_001272342.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_001272344.1 TIGRFAM: PTS system, glucose subfamily, IIA subunit; sugar (Glycoside-Pentoside-Hexuronide) transporter; PFAM: sugar-specific permease, EIIA 1 domain YP_001272345.1 PFAM: UspA domain protein YP_001272346.1 PFAM: regulatory protein, AsnC/Lrp family YP_001272347.1 PFAM: sodium:dicarboxylate symporter YP_001272348.1 PFAM: SNARE associated Golgi protein YP_001272351.1 PFAM: regulatory protein, LacI YP_001272352.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism YP_001272353.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_001272356.1 PFAM: PEBP family protein YP_001272360.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001272361.1 TIGRFAM: nicotinamide mononucleotide transporter PnuC; PFAM: Nicotinamide mononucleotide transporter PnuC YP_001272362.1 PFAM: aldo/keto reductase YP_001272363.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001272364.1 PFAM: ATP-binding region, ATPase domain protein domain protein YP_001272365.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001272367.1 PFAM: homoserine O-succinyltransferase YP_001272368.1 TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein, beta subunit YP_001272369.1 PFAM: phospholipase D/Transphosphatidylase YP_001272370.1 PFAM: major facilitator superfamily MFS_1 YP_001272371.1 PFAM: Appr-1-p processing domain protein YP_001272372.1 PFAM: helix-turn-helix domain protein YP_001272373.1 PFAM: peptidase M13, neprilysin; peptidase M13 YP_001272377.1 TIGRFAM: DNA-3-methyladenine glycosylase; PFAM: methylpurine-DNA glycosylase (MPG) YP_001272378.1 PFAM: protein of unknown function DUF488 YP_001272380.1 PFAM: NAD(P)H dehydrogenase (quinone) YP_001272385.1 PFAM: phosphoesterase, DHHA1 YP_001272387.1 PFAM: branched-chain amino acid transport system II carrier protein YP_001272388.1 PFAM: Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase; SMART: Lysozyme subfamily 2 YP_001272389.1 PFAM: protein of unknown function DUF1113 YP_001272390.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001272392.1 PFAM: NLP/P60 protein; Peptidoglycan-binding LysM YP_001272393.1 PFAM: protein of unknown function DUF534 YP_001272394.1 PFAM: inner-membrane translocator YP_001272395.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001272397.1 PFAM: regulatory protein, ArsR YP_001272398.1 TIGRFAM: MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE YP_001272399.1 TIGRFAM: thioredoxin; PFAM: Thioredoxin domain YP_001272400.1 PFAM: Integral membrane protein TerC YP_001272401.1 PFAM: pseudouridine synthase YP_001272403.1 PFAM: peptidase U34, dipeptidase YP_001272404.1 TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; sulphate transporter YP_001272405.1 PFAM: Na+/H+ antiporter NhaC YP_001272406.1 TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S); Anticodon-binding domain protein YP_001272408.1 TIGRFAM: histidine decarboxylase, pyruvoyl type; PFAM: histidine carboxylase, PI chain YP_001272409.1 PFAM: amino acid permease-associated region; Amino acid transporter, transmembrane YP_001272412.1 PFAM: C4-dicarboxylate anaerobic carrier; Citrate transporter YP_001272413.1 PFAM: Phosphoglycerate mutase YP_001272415.1 PFAM: sulfatase YP_001272416.1 PFAM: iron-containing alcohol dehydrogenase; 3-dehydroquinate synthase YP_001272417.1 PFAM: hydrolase family protein YP_001272418.1 PFAM: peptidase S11, D-alanyl-D-alanine carboxypeptidase 1 YP_001272420.1 PFAM: ErfK/YbiS/YcfS/YnhG family protein YP_001272421.1 TIGRFAM: carbohydrate kinase, YjeF related protein; PFAM: YjeF-family N-terminal domain protein YP_001272423.1 TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S); Anticodon-binding domain protein YP_001272424.1 PFAM: major facilitator superfamily MFS_1 YP_001272427.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001272428.1 PFAM: Peptidoglycan-binding LysM; Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase; SMART: Lysozyme subfamily 2 YP_001272429.1 PFAM: regulatory protein, ArsR YP_001272431.1 PFAM: ABC transporter related; protein of unknown function DUF214; SMART: AAA ATPase YP_001272432.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001272433.1 PFAM: protein of unknown function DUF214 YP_001272434.1 PFAM: regulatory protein, TetR YP_001272435.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001272436.1 TIGRFAM: Mn2+/Fe2+ transporter, NRAMP family; PFAM: natural resistance-associated macrophage protein YP_001272438.1 TIGRFAM: threonyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S); Anticodon-binding domain protein; Threonyl/alanyl tRNA synthetase, SAD YP_001272439.1 PFAM: type I phosphodiesterase/nucleotide pyrophosphatase YP_001272440.1 PFAM: Spore germination protein; amino acid permease-associated region YP_001272441.1 TIGRFAM: 2-dehydropantoate 2-reductase; PFAM: Ketopantoate reductase ApbA/PanE, N-terminal domain protein; Ketopantoate reductase ApbA/PanE, C-terminal domain protein YP_001272442.1 PFAM: helix-turn-helix domain protein YP_001272444.1 PFAM: Methionine synthase, vitamin-B12 independent YP_001272445.1 PFAM: cytochrome b5 YP_001272446.1 PFAM: cytochrome b5 YP_001272447.1 PFAM: cytochrome b5 YP_001272448.1 PFAM: GCN5-related N-acetyltransferase YP_001272450.1 PFAM: helix-turn-helix, HxlR type YP_001272452.1 PFAM: regulatory protein, ArsR; helix-turn-helix, HxlR type YP_001272454.1 PFAM: major facilitator superfamily MFS_1 YP_001272455.1 PFAM: peptidase C1B, bleomycin hydrolase YP_001272456.1 PFAM: NAD-dependent epimerase/dehydratase YP_001272457.1 PFAM: Peptidase M1, membrane alanine aminopeptidase-like YP_001272459.1 catalyzes the formation of asparagine from aspartate and ammonia YP_001272460.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001272461.1 PFAM: EAL domain protein YP_001272462.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein YP_001272464.1 PFAM: glycosyl transferase, family 2 YP_001272466.1 PFAM: transposase IS200-family protein YP_001272467.1 PFAM: glutamine amidotransferase class-I YP_001272471.1 PFAM: regulatory protein, TetR YP_001272472.1 PFAM: aldo/keto reductase YP_001272473.1 PFAM: regulatory protein, LysR YP_001272474.1 TIGRFAM: L-asparaginase, type I; PFAM: Asparaginase/glutaminase YP_001272475.1 PFAM: protein of unknown function DUF1002 YP_001272476.1 PFAM: aminotransferase, class I and II YP_001272477.1 PFAM: Lactate/malate dehydrogenase YP_001272478.1 PFAM: Hydratase/decarboxylase YP_001272479.1 PFAM: hydrolase family protein YP_001272480.1 PFAM: transferase hexapeptide repeat containing protein YP_001272481.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001272483.1 PFAM: Carboxymuconolactone decarboxylase YP_001272485.1 PFAM: aminotransferase, class I and II YP_001272486.1 PFAM: Auxin Efflux Carrier YP_001272487.1 PFAM: bifunctional deaminase-reductase domain protein YP_001272488.1 PFAM: Integrase, catalytic region YP_001272491.1 PFAM: YbaK/prolyl-tRNA synthetase associated region YP_001272492.1 PFAM: Antibiotic biosynthesis monooxygenase YP_001272493.1 PFAM: beta-lactamase YP_001272494.1 TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase YP_001272495.1 PFAM: MgtC/SapB transporter YP_001272498.1 PFAM: branched-chain amino acid transport YP_001272499.1 PFAM: AzlC family protein YP_001272500.1 PFAM: regulatory protein GntR, HTH; aminotransferase, class I and II YP_001272501.1 PFAM: amidohydrolase; Amidohydrolase 3 YP_001272502.1 PFAM: aldo/keto reductase YP_001272503.1 PFAM: GCN5-related N-acetyltransferase YP_001272504.1 TIGRFAM: signal peptidase I; PFAM: peptidase S24, S26A and S26B YP_001272506.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_001272507.1 TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase, class-II; asparagine synthase YP_001272508.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001272509.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001272510.1 PFAM: single-stranded nucleic acid binding R3H domain protein YP_001272511.1 PFAM: 60 kDa inner membrane insertion protein YP_001272512.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_001272513.1 in Escherichia coli transcription of this gene is enhanced by polyamines