-- dump date 20140619_124357 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1340495000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1340495000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1340495000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495000004 Walker A motif; other site 1340495000005 ATP binding site [chemical binding]; other site 1340495000006 Walker B motif; other site 1340495000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 1340495000008 arginine finger; other site 1340495000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1340495000010 DnaA box-binding interface [nucleotide binding]; other site 1340495000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1340495000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1340495000013 putative DNA binding surface [nucleotide binding]; other site 1340495000014 dimer interface [polypeptide binding]; other site 1340495000015 beta-clamp/clamp loader binding surface; other site 1340495000016 beta-clamp/translesion DNA polymerase binding surface; other site 1340495000017 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1340495000018 classical (c) SDRs; Region: SDR_c; cd05233 1340495000019 NAD(P) binding site [chemical binding]; other site 1340495000020 active site 1340495000021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1340495000022 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1340495000023 recombination protein F; Reviewed; Region: recF; PRK00064 1340495000024 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1340495000025 Walker A/P-loop; other site 1340495000026 ATP binding site [chemical binding]; other site 1340495000027 Q-loop/lid; other site 1340495000028 ABC transporter signature motif; other site 1340495000029 Walker B; other site 1340495000030 D-loop; other site 1340495000031 H-loop/switch region; other site 1340495000032 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1340495000033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1340495000034 ATP binding site [chemical binding]; other site 1340495000035 Mg2+ binding site [ion binding]; other site 1340495000036 G-X-G motif; other site 1340495000037 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1340495000038 anchoring element; other site 1340495000039 dimer interface [polypeptide binding]; other site 1340495000040 ATP binding site [chemical binding]; other site 1340495000041 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1340495000042 active site 1340495000043 putative metal-binding site [ion binding]; other site 1340495000044 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1340495000045 DNA gyrase subunit A; Validated; Region: PRK05560 1340495000046 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1340495000047 CAP-like domain; other site 1340495000048 active site 1340495000049 primary dimer interface [polypeptide binding]; other site 1340495000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1340495000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1340495000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1340495000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1340495000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1340495000055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1340495000056 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1340495000057 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1340495000058 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1340495000059 dimer interface [polypeptide binding]; other site 1340495000060 ssDNA binding site [nucleotide binding]; other site 1340495000061 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1340495000062 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1340495000063 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1340495000064 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1340495000065 DHH family; Region: DHH; pfam01368 1340495000066 DHHA1 domain; Region: DHHA1; pfam02272 1340495000067 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1340495000068 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1340495000069 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1340495000070 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1340495000071 replicative DNA helicase; Provisional; Region: PRK05748 1340495000072 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1340495000073 Walker A motif; other site 1340495000074 ATP binding site [chemical binding]; other site 1340495000075 Walker B motif; other site 1340495000076 DNA binding loops [nucleotide binding] 1340495000077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495000078 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1340495000079 putative substrate translocation pore; other site 1340495000080 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1340495000081 transposase/IS protein; Provisional; Region: PRK09183 1340495000082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495000083 Walker A motif; other site 1340495000084 ATP binding site [chemical binding]; other site 1340495000085 Walker B motif; other site 1340495000086 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1340495000087 Integrase core domain; Region: rve; pfam00665 1340495000088 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1340495000089 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1340495000090 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1340495000091 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1340495000092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340495000093 Walker A/P-loop; other site 1340495000094 ATP binding site [chemical binding]; other site 1340495000095 Q-loop/lid; other site 1340495000096 ABC transporter signature motif; other site 1340495000097 Walker B; other site 1340495000098 D-loop; other site 1340495000099 H-loop/switch region; other site 1340495000100 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1340495000101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1340495000102 active site 1340495000103 phosphorylation site [posttranslational modification] 1340495000104 intermolecular recognition site; other site 1340495000105 dimerization interface [polypeptide binding]; other site 1340495000106 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1340495000107 DNA binding site [nucleotide binding] 1340495000108 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1340495000109 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1340495000110 dimerization interface [polypeptide binding]; other site 1340495000111 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1340495000112 putative active site [active] 1340495000113 heme pocket [chemical binding]; other site 1340495000114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1340495000115 dimer interface [polypeptide binding]; other site 1340495000116 phosphorylation site [posttranslational modification] 1340495000117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1340495000118 ATP binding site [chemical binding]; other site 1340495000119 Mg2+ binding site [ion binding]; other site 1340495000120 G-X-G motif; other site 1340495000121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1340495000122 YycH protein; Region: YycH; pfam07435 1340495000123 YycH protein; Region: YycI; pfam09648 1340495000124 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1340495000125 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1340495000126 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1340495000127 protein binding site [polypeptide binding]; other site 1340495000128 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1340495000129 tetramer interfaces [polypeptide binding]; other site 1340495000130 binuclear metal-binding site [ion binding]; other site 1340495000131 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1340495000132 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1340495000133 zinc binding site [ion binding]; other site 1340495000134 putative ligand binding site [chemical binding]; other site 1340495000135 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1340495000136 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1340495000137 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1340495000138 dimer interface [polypeptide binding]; other site 1340495000139 active site 1340495000140 metal binding site [ion binding]; metal-binding site 1340495000141 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1340495000142 Sugar transport protein; Region: Sugar_transport; cl19288 1340495000143 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1340495000144 active site 1340495000145 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1340495000146 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 1340495000147 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 1340495000148 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1340495000149 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495000150 Integrase core domain; Region: rve; pfam00665 1340495000151 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1340495000152 HlyD family secretion protein; Region: HlyD_3; pfam13437 1340495000153 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1340495000154 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1340495000155 Walker A/P-loop; other site 1340495000156 ATP binding site [chemical binding]; other site 1340495000157 Q-loop/lid; other site 1340495000158 ABC transporter signature motif; other site 1340495000159 Walker B; other site 1340495000160 D-loop; other site 1340495000161 H-loop/switch region; other site 1340495000162 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1340495000163 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1340495000164 FtsX-like permease family; Region: FtsX; pfam02687 1340495000165 chain length determinant protein WzzB; Provisional; Region: PRK15471 1340495000166 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 1340495000167 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495000168 Integrase core domain; Region: rve; pfam00665 1340495000169 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1340495000170 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1340495000171 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1340495000172 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495000173 Integrase core domain; Region: rve; pfam00665 1340495000174 OsmC-like protein; Region: OsmC; pfam02566 1340495000175 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1340495000176 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1340495000177 homodimer interface [polypeptide binding]; other site 1340495000178 ligand binding site [chemical binding]; other site 1340495000179 NAD binding site [chemical binding]; other site 1340495000180 catalytic site [active] 1340495000181 aminotransferase A; Validated; Region: PRK07683 1340495000182 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1340495000183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1340495000184 homodimer interface [polypeptide binding]; other site 1340495000185 catalytic residue [active] 1340495000186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495000187 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1340495000188 Walker A motif; other site 1340495000189 ATP binding site [chemical binding]; other site 1340495000190 Walker B motif; other site 1340495000191 arginine finger; other site 1340495000192 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 1340495000193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495000194 Walker A motif; other site 1340495000195 ATP binding site [chemical binding]; other site 1340495000196 Walker B motif; other site 1340495000197 arginine finger; other site 1340495000198 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1340495000199 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 1340495000200 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1340495000201 Coenzyme A binding pocket [chemical binding]; other site 1340495000202 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1340495000203 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1340495000204 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1340495000205 putative active site [active] 1340495000206 catalytic site [active] 1340495000207 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1340495000208 putative active site [active] 1340495000209 catalytic site [active] 1340495000210 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1340495000211 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1340495000212 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1340495000213 Part of AAA domain; Region: AAA_19; pfam13245 1340495000214 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 1340495000215 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1340495000216 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1340495000217 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1340495000218 DNA binding site [nucleotide binding] 1340495000219 domain linker motif; other site 1340495000220 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1340495000221 putative dimerization interface [polypeptide binding]; other site 1340495000222 putative ligand binding site [chemical binding]; other site 1340495000223 putative acyltransferase; Provisional; Region: PRK05790 1340495000224 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1340495000225 dimer interface [polypeptide binding]; other site 1340495000226 active site 1340495000227 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1340495000228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495000229 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 1340495000230 putative substrate translocation pore; other site 1340495000231 maltose phosphorylase; Provisional; Region: PRK13807 1340495000232 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1340495000233 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1340495000234 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1340495000235 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 1340495000236 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1340495000237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1340495000238 motif II; other site 1340495000239 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1340495000240 synthetase active site [active] 1340495000241 NTP binding site [chemical binding]; other site 1340495000242 metal binding site [ion binding]; metal-binding site 1340495000243 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1340495000244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1340495000245 active site 1340495000246 phosphorylation site [posttranslational modification] 1340495000247 intermolecular recognition site; other site 1340495000248 dimerization interface [polypeptide binding]; other site 1340495000249 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1340495000250 DNA binding site [nucleotide binding] 1340495000251 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1340495000252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1340495000253 dimer interface [polypeptide binding]; other site 1340495000254 phosphorylation site [posttranslational modification] 1340495000255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1340495000256 ATP binding site [chemical binding]; other site 1340495000257 Mg2+ binding site [ion binding]; other site 1340495000258 G-X-G motif; other site 1340495000259 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1340495000260 Cl- selectivity filter; other site 1340495000261 Cl- binding residues [ion binding]; other site 1340495000262 pore gating glutamate residue; other site 1340495000263 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1340495000264 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1340495000265 Peptidase C26; Region: Peptidase_C26; pfam07722 1340495000266 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1340495000267 catalytic triad [active] 1340495000268 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1340495000269 active site 1340495000270 catalytic tetrad [active] 1340495000271 Cupin domain; Region: Cupin_2; cl17218 1340495000272 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 1340495000273 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1340495000274 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1340495000275 putative active site [active] 1340495000276 catalytic site [active] 1340495000277 putative metal binding site [ion binding]; other site 1340495000278 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1340495000279 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1340495000280 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1340495000281 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1340495000282 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 1340495000283 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1340495000284 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1340495000285 active site 1340495000286 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1340495000287 GDP-binding site [chemical binding]; other site 1340495000288 ACT binding site; other site 1340495000289 IMP binding site; other site 1340495000290 hypothetical protein; Provisional; Region: PRK11281 1340495000291 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1340495000292 active site 1340495000293 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1340495000294 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1340495000295 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1340495000296 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1340495000297 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1340495000298 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1340495000299 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1340495000300 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1340495000301 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1340495000302 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1340495000303 Ca binding site [ion binding]; other site 1340495000304 active site 1340495000305 catalytic site [active] 1340495000306 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1340495000307 putative symporter YagG; Provisional; Region: PRK09669; cl15392 1340495000308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495000309 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1340495000310 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1340495000311 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1340495000312 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 1340495000313 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1340495000314 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1340495000315 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 1340495000316 substrate binding site [chemical binding]; other site 1340495000317 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1340495000318 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1340495000319 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1340495000320 catalytic site [active] 1340495000321 subunit interface [polypeptide binding]; other site 1340495000322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495000323 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 1340495000324 putative substrate translocation pore; other site 1340495000325 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1340495000326 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1340495000327 DNA binding site [nucleotide binding] 1340495000328 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1340495000329 dimerization interface [polypeptide binding]; other site 1340495000330 ligand binding site [chemical binding]; other site 1340495000331 TRAM domain; Region: TRAM; pfam01938 1340495000332 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1340495000333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340495000334 S-adenosylmethionine binding site [chemical binding]; other site 1340495000335 Predicted flavoprotein [General function prediction only]; Region: COG0431 1340495000336 Predicted flavoprotein [General function prediction only]; Region: COG0431 1340495000337 PAS domain; Region: PAS_10; pfam13596 1340495000338 Colicin M; Region: Colicin_M; pfam14859 1340495000339 ApbE family; Region: ApbE; pfam02424 1340495000340 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1340495000341 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1340495000342 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495000343 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495000344 Integrase core domain; Region: rve; pfam00665 1340495000345 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1340495000346 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495000347 Integrase core domain; Region: rve; pfam00665 1340495000348 Membrane transport protein; Region: Mem_trans; cl09117 1340495000349 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1340495000350 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1340495000351 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1340495000352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1340495000353 active site 1340495000354 phosphorylation site [posttranslational modification] 1340495000355 intermolecular recognition site; other site 1340495000356 dimerization interface [polypeptide binding]; other site 1340495000357 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1340495000358 DNA binding site [nucleotide binding] 1340495000359 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1340495000360 HAMP domain; Region: HAMP; pfam00672 1340495000361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1340495000362 dimer interface [polypeptide binding]; other site 1340495000363 phosphorylation site [posttranslational modification] 1340495000364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1340495000365 ATP binding site [chemical binding]; other site 1340495000366 Mg2+ binding site [ion binding]; other site 1340495000367 G-X-G motif; other site 1340495000368 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1340495000369 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1340495000370 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1340495000371 beta-alpha-beta structure motif; other site 1340495000372 NAD binding pocket [chemical binding]; other site 1340495000373 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1340495000374 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1340495000375 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1340495000376 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1340495000377 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1340495000378 active site 1340495000379 catalytic tetrad [active] 1340495000380 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1340495000381 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1340495000382 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1340495000383 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1340495000384 dimerization interface [polypeptide binding]; other site 1340495000385 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1340495000386 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1340495000387 putative trimer interface [polypeptide binding]; other site 1340495000388 putative CoA binding site [chemical binding]; other site 1340495000389 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1340495000390 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1340495000391 Phenolic Acid Decarboxylase; Region: PAD; cd14241 1340495000392 active site 1340495000393 dimer interface [polypeptide binding]; other site 1340495000394 Predicted transcriptional regulators [Transcription]; Region: COG1695 1340495000395 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1340495000396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1340495000397 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1340495000398 NAD(P) binding site [chemical binding]; other site 1340495000399 active site 1340495000400 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1340495000401 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 1340495000402 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1340495000403 active site 1340495000404 homodimer interface [polypeptide binding]; other site 1340495000405 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1340495000406 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1340495000407 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1340495000408 active site 1340495000409 catalytic tetrad [active] 1340495000410 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1340495000411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1340495000412 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1340495000413 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 1340495000414 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 1340495000415 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1340495000416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1340495000417 NAD(P) binding site [chemical binding]; other site 1340495000418 active site 1340495000419 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1340495000420 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1340495000421 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1340495000422 catalytic triad [active] 1340495000423 EAL domain; Region: EAL; pfam00563 1340495000424 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 1340495000425 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495000426 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495000427 Integrase core domain; Region: rve; pfam00665 1340495000428 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495000429 Integrase core domain; Region: rve; pfam00665 1340495000430 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1340495000431 metal binding site [ion binding]; metal-binding site 1340495000432 EAL domain; Region: EAL; pfam00563 1340495000433 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1340495000434 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1340495000435 putative dimer interface [polypeptide binding]; other site 1340495000436 putative anticodon binding site; other site 1340495000437 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1340495000438 homodimer interface [polypeptide binding]; other site 1340495000439 motif 1; other site 1340495000440 motif 2; other site 1340495000441 active site 1340495000442 motif 3; other site 1340495000443 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1340495000444 dimer interface [polypeptide binding]; other site 1340495000445 active site 1340495000446 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1340495000447 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1340495000448 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1340495000449 Zn binding site [ion binding]; other site 1340495000450 ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838 1340495000451 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1340495000452 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1340495000453 NAD(P) binding site [chemical binding]; other site 1340495000454 putative active site [active] 1340495000455 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1340495000456 trimer interface [polypeptide binding]; other site 1340495000457 active site 1340495000458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495000459 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1340495000460 putative substrate translocation pore; other site 1340495000461 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1340495000462 dimerization interface [polypeptide binding]; other site 1340495000463 putative DNA binding site [nucleotide binding]; other site 1340495000464 putative Zn2+ binding site [ion binding]; other site 1340495000465 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1340495000466 dimer interface [polypeptide binding]; other site 1340495000467 FMN binding site [chemical binding]; other site 1340495000468 Predicted transcriptional regulators [Transcription]; Region: COG1733 1340495000469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1340495000470 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1340495000471 NAD(P) binding site [chemical binding]; other site 1340495000472 active site 1340495000473 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1340495000474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1340495000475 Coenzyme A binding pocket [chemical binding]; other site 1340495000476 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1340495000477 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 1340495000478 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495000479 Integrase core domain; Region: rve; pfam00665 1340495000480 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 1340495000481 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 1340495000482 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1340495000483 substrate binding site [chemical binding]; other site 1340495000484 THF binding site; other site 1340495000485 zinc-binding site [ion binding]; other site 1340495000486 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 1340495000487 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1340495000488 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1340495000489 amino acid transporter; Region: 2A0306; TIGR00909 1340495000490 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1340495000491 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1340495000492 Sulfatase; Region: Sulfatase; cl19157 1340495000493 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1340495000494 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1340495000495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495000496 putative substrate translocation pore; other site 1340495000497 Helix-turn-helix domain; Region: HTH_28; pfam13518 1340495000498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1340495000499 Helix-turn-helix domain; Region: HTH_28; pfam13518 1340495000500 putative transposase OrfB; Reviewed; Region: PHA02517 1340495000501 HTH-like domain; Region: HTH_21; pfam13276 1340495000502 Integrase core domain; Region: rve; pfam00665 1340495000503 Integrase core domain; Region: rve_3; cl15866 1340495000504 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1340495000505 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1340495000506 active site 1340495000507 dimer interface [polypeptide binding]; other site 1340495000508 motif 1; other site 1340495000509 motif 2; other site 1340495000510 motif 3; other site 1340495000511 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1340495000512 anticodon binding site; other site 1340495000513 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1340495000514 manganese transport protein MntH; Reviewed; Region: PRK00701 1340495000515 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1340495000516 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1340495000517 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 1340495000518 putative NAD(P) binding site [chemical binding]; other site 1340495000519 catalytic Zn binding site [ion binding]; other site 1340495000520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1340495000521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1340495000522 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1340495000523 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1340495000524 FtsX-like permease family; Region: FtsX; pfam02687 1340495000525 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1340495000526 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1340495000527 Walker A/P-loop; other site 1340495000528 ATP binding site [chemical binding]; other site 1340495000529 Q-loop/lid; other site 1340495000530 ABC transporter signature motif; other site 1340495000531 Walker B; other site 1340495000532 D-loop; other site 1340495000533 H-loop/switch region; other site 1340495000534 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1340495000535 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1340495000536 Walker A/P-loop; other site 1340495000537 ATP binding site [chemical binding]; other site 1340495000538 Q-loop/lid; other site 1340495000539 ABC transporter signature motif; other site 1340495000540 Walker B; other site 1340495000541 D-loop; other site 1340495000542 H-loop/switch region; other site 1340495000543 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1340495000544 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1340495000545 FtsX-like permease family; Region: FtsX; pfam02687 1340495000546 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1340495000547 putative Zn2+ binding site [ion binding]; other site 1340495000548 putative DNA binding site [nucleotide binding]; other site 1340495000549 dimerization interface [polypeptide binding]; other site 1340495000550 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1340495000551 autolysin; Reviewed; Region: PRK06347 1340495000552 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1340495000553 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1340495000554 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1340495000555 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1340495000556 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1340495000557 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1340495000558 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1340495000559 DNA binding site [nucleotide binding] 1340495000560 domain linker motif; other site 1340495000561 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1340495000562 dimerization interface [polypeptide binding]; other site 1340495000563 ligand binding site [chemical binding]; other site 1340495000564 sodium binding site [ion binding]; other site 1340495000565 Uncharacterized conserved protein [Function unknown]; Region: COG4095 1340495000566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495000567 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1340495000568 putative substrate translocation pore; other site 1340495000569 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1340495000570 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1340495000571 dimer interface [polypeptide binding]; other site 1340495000572 motif 1; other site 1340495000573 active site 1340495000574 motif 2; other site 1340495000575 motif 3; other site 1340495000576 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1340495000577 anticodon binding site; other site 1340495000578 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1340495000579 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1340495000580 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1340495000581 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1340495000582 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1340495000583 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1340495000584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1340495000585 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1340495000586 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1340495000587 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 1340495000588 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1340495000589 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1340495000590 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1340495000591 dimer interface [polypeptide binding]; other site 1340495000592 active site 1340495000593 metal binding site [ion binding]; metal-binding site 1340495000594 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1340495000595 Sulfatase; Region: Sulfatase; pfam00884 1340495000596 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1340495000597 catalytic core [active] 1340495000598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1340495000599 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1340495000600 Helix-turn-helix domain; Region: HTH_28; pfam13518 1340495000601 HTH-like domain; Region: HTH_21; pfam13276 1340495000602 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1340495000603 Integrase core domain; Region: rve; pfam00665 1340495000604 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 1340495000605 Predicted membrane protein [Function unknown]; Region: COG1288 1340495000606 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1340495000607 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1340495000608 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1340495000609 Sulfate transporter family; Region: Sulfate_transp; cl19250 1340495000610 xanthine permease; Region: pbuX; TIGR03173 1340495000611 Peptidase family C69; Region: Peptidase_C69; pfam03577 1340495000612 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1340495000613 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1340495000614 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1340495000615 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1340495000616 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1340495000617 Cl binding site [ion binding]; other site 1340495000618 oligomer interface [polypeptide binding]; other site 1340495000619 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1340495000620 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1340495000621 active site 1340495000622 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1340495000623 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1340495000624 catalytic residues [active] 1340495000625 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1340495000626 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1340495000627 MucBP domain; Region: MucBP; pfam06458 1340495000628 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1340495000629 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1340495000630 dimerization interface [polypeptide binding]; other site 1340495000631 putative DNA binding site [nucleotide binding]; other site 1340495000632 putative Zn2+ binding site [ion binding]; other site 1340495000633 Cadmium resistance transporter; Region: Cad; cl19409 1340495000634 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1340495000635 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340495000636 Walker A/P-loop; other site 1340495000637 ATP binding site [chemical binding]; other site 1340495000638 Q-loop/lid; other site 1340495000639 ABC transporter signature motif; other site 1340495000640 Walker B; other site 1340495000641 D-loop; other site 1340495000642 H-loop/switch region; other site 1340495000643 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1340495000644 TM-ABC transporter signature motif; other site 1340495000645 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1340495000646 zinc binding site [ion binding]; other site 1340495000647 putative ligand binding site [chemical binding]; other site 1340495000648 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1340495000649 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1340495000650 NlpC/P60 family; Region: NLPC_P60; pfam00877 1340495000651 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495000652 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495000653 Integrase core domain; Region: rve; pfam00665 1340495000654 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495000655 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495000656 Integrase core domain; Region: rve; pfam00665 1340495000657 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495000658 Integrase core domain; Region: rve; pfam00665 1340495000659 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1340495000660 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1340495000661 ABC transporter; Region: ABC_tran_2; pfam12848 1340495000662 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1340495000663 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1340495000664 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1340495000665 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1340495000666 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1340495000667 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 1340495000668 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1340495000669 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1340495000670 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1340495000671 Protein of unknown function, DUF488; Region: DUF488; cl01246 1340495000672 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1340495000673 active site 1340495000674 DNA binding site [nucleotide binding] 1340495000675 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495000676 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1340495000677 Walker A motif; other site 1340495000678 ATP binding site [chemical binding]; other site 1340495000679 Walker B motif; other site 1340495000680 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 1340495000681 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1340495000682 metal ion-dependent adhesion site (MIDAS); other site 1340495000683 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1340495000684 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1340495000685 active site 1340495000686 Zn binding site [ion binding]; other site 1340495000687 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1340495000688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1340495000689 non-specific DNA binding site [nucleotide binding]; other site 1340495000690 salt bridge; other site 1340495000691 sequence-specific DNA binding site [nucleotide binding]; other site 1340495000692 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1340495000693 putative ADP-ribose binding site [chemical binding]; other site 1340495000694 putative active site [active] 1340495000695 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1340495000696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495000697 putative substrate translocation pore; other site 1340495000698 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1340495000699 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1340495000700 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1340495000701 putative active site [active] 1340495000702 catalytic site [active] 1340495000703 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1340495000704 putative active site [active] 1340495000705 catalytic site [active] 1340495000706 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495000707 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495000708 Integrase core domain; Region: rve; pfam00665 1340495000709 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1340495000710 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1340495000711 DNA binding residues [nucleotide binding] 1340495000712 dimer interface [polypeptide binding]; other site 1340495000713 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495000714 Integrase core domain; Region: rve; pfam00665 1340495000715 cysteine synthase; Region: PLN02565 1340495000716 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1340495000717 dimer interface [polypeptide binding]; other site 1340495000718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1340495000719 catalytic residue [active] 1340495000720 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1340495000721 proposed active site lysine [active] 1340495000722 conserved cys residue [active] 1340495000723 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495000724 Integrase core domain; Region: rve; pfam00665 1340495000725 FtsX-like permease family; Region: FtsX; pfam02687 1340495000726 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1340495000727 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1340495000728 Walker A/P-loop; other site 1340495000729 ATP binding site [chemical binding]; other site 1340495000730 Q-loop/lid; other site 1340495000731 ABC transporter signature motif; other site 1340495000732 Walker B; other site 1340495000733 D-loop; other site 1340495000734 H-loop/switch region; other site 1340495000735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1340495000736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1340495000737 ATP binding site [chemical binding]; other site 1340495000738 Mg2+ binding site [ion binding]; other site 1340495000739 G-X-G motif; other site 1340495000740 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1340495000741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1340495000742 active site 1340495000743 phosphorylation site [posttranslational modification] 1340495000744 intermolecular recognition site; other site 1340495000745 dimerization interface [polypeptide binding]; other site 1340495000746 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1340495000747 DNA binding site [nucleotide binding] 1340495000748 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1340495000749 active site 1340495000750 catalytic tetrad [active] 1340495000751 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1340495000752 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1340495000753 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1340495000754 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1340495000755 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1340495000756 substrate binding site [chemical binding]; other site 1340495000757 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1340495000758 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1340495000759 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1340495000760 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 1340495000761 active site 1340495000762 catalytic triad [active] 1340495000763 oxyanion hole [active] 1340495000764 galactokinase; Provisional; Region: PRK05322 1340495000765 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1340495000766 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1340495000767 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1340495000768 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1340495000769 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1340495000770 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1340495000771 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1340495000772 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1340495000773 DNA binding site [nucleotide binding] 1340495000774 domain linker motif; other site 1340495000775 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1340495000776 putative dimerization interface [polypeptide binding]; other site 1340495000777 putative ligand binding site [chemical binding]; other site 1340495000778 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1340495000779 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1340495000780 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495000781 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495000782 Integrase core domain; Region: rve; pfam00665 1340495000783 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1340495000784 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1340495000785 putative DNA binding site [nucleotide binding]; other site 1340495000786 putative Zn2+ binding site [ion binding]; other site 1340495000787 AsnC family; Region: AsnC_trans_reg; pfam01037 1340495000788 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1340495000789 Ligand Binding Site [chemical binding]; other site 1340495000790 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1340495000791 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1340495000792 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1340495000793 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1340495000794 Probable transposase; Region: OrfB_IS605; pfam01385 1340495000795 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1340495000796 putative symporter YagG; Provisional; Region: PRK09669; cl15392 1340495000797 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1340495000798 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1340495000799 HPr interaction site; other site 1340495000800 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1340495000801 active site 1340495000802 phosphorylation site [posttranslational modification] 1340495000803 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495000804 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495000805 Integrase core domain; Region: rve; pfam00665 1340495000806 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1340495000807 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1340495000808 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1340495000809 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1340495000810 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1340495000811 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1340495000812 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1340495000813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495000814 putative substrate translocation pore; other site 1340495000815 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1340495000816 dimer interface [polypeptide binding]; other site 1340495000817 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 1340495000818 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1340495000819 Domain of unknown function DUF21; Region: DUF21; pfam01595 1340495000820 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1340495000821 Transporter associated domain; Region: CorC_HlyC; smart01091 1340495000822 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1340495000823 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340495000824 Walker A/P-loop; other site 1340495000825 ATP binding site [chemical binding]; other site 1340495000826 Q-loop/lid; other site 1340495000827 ABC transporter signature motif; other site 1340495000828 Walker B; other site 1340495000829 D-loop; other site 1340495000830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1340495000831 active site 1340495000832 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1340495000833 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1340495000834 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1340495000835 B3/4 domain; Region: B3_4; cl19243 1340495000836 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1340495000837 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1340495000838 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1340495000839 Integrase core domain; Region: rve; pfam00665 1340495000840 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495000841 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495000842 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1340495000843 amphipathic channel; other site 1340495000844 Asn-Pro-Ala signature motifs; other site 1340495000845 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1340495000846 D-lactate dehydrogenase; Validated; Region: PRK08605 1340495000847 homodimer interface [polypeptide binding]; other site 1340495000848 ligand binding site [chemical binding]; other site 1340495000849 NAD binding site [chemical binding]; other site 1340495000850 catalytic site [active] 1340495000851 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1340495000852 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1340495000853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340495000854 Walker A/P-loop; other site 1340495000855 ATP binding site [chemical binding]; other site 1340495000856 Q-loop/lid; other site 1340495000857 ABC transporter signature motif; other site 1340495000858 Walker B; other site 1340495000859 D-loop; other site 1340495000860 H-loop/switch region; other site 1340495000861 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1340495000862 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1340495000863 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1340495000864 Walker A/P-loop; other site 1340495000865 ATP binding site [chemical binding]; other site 1340495000866 Q-loop/lid; other site 1340495000867 ABC transporter signature motif; other site 1340495000868 Walker B; other site 1340495000869 D-loop; other site 1340495000870 H-loop/switch region; other site 1340495000871 Peptidase family C69; Region: Peptidase_C69; pfam03577 1340495000872 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1340495000873 putative deacylase active site [active] 1340495000874 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1340495000875 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1340495000876 DNA-binding site [nucleotide binding]; DNA binding site 1340495000877 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1340495000878 putative phosphoketolase; Provisional; Region: PRK05261 1340495000879 XFP N-terminal domain; Region: XFP_N; pfam09364 1340495000880 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1340495000881 XFP C-terminal domain; Region: XFP_C; pfam09363 1340495000882 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1340495000883 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1340495000884 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1340495000885 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1340495000886 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 1340495000887 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1340495000888 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1340495000889 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1340495000890 nucleotide binding site [chemical binding]; other site 1340495000891 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1340495000892 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1340495000893 G1 box; other site 1340495000894 GTP/Mg2+ binding site [chemical binding]; other site 1340495000895 G2 box; other site 1340495000896 Switch I region; other site 1340495000897 G3 box; other site 1340495000898 Switch II region; other site 1340495000899 G4 box; other site 1340495000900 G5 box; other site 1340495000901 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1340495000902 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1340495000903 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1340495000904 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1340495000905 Ligand Binding Site [chemical binding]; other site 1340495000906 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1340495000907 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1340495000908 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1340495000909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5011 1340495000910 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1340495000911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495000912 putative substrate translocation pore; other site 1340495000913 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 1340495000914 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 1340495000915 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1340495000916 putative NAD(P) binding site [chemical binding]; other site 1340495000917 substrate binding site [chemical binding]; other site 1340495000918 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1340495000919 active site 1340495000920 metal binding site [ion binding]; metal-binding site 1340495000921 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1340495000922 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1340495000923 non-specific DNA binding site [nucleotide binding]; other site 1340495000924 salt bridge; other site 1340495000925 sequence-specific DNA binding site [nucleotide binding]; other site 1340495000926 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1340495000927 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1340495000928 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1340495000929 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 1340495000930 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1340495000931 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1340495000932 Tic20-like protein; Region: Tic20; pfam09685 1340495000933 Cobalt transport protein; Region: CbiQ; cl00463 1340495000934 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1340495000935 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1340495000936 Walker A/P-loop; other site 1340495000937 ATP binding site [chemical binding]; other site 1340495000938 Q-loop/lid; other site 1340495000939 ABC transporter signature motif; other site 1340495000940 Walker B; other site 1340495000941 D-loop; other site 1340495000942 H-loop/switch region; other site 1340495000943 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1340495000944 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1340495000945 Walker A/P-loop; other site 1340495000946 ATP binding site [chemical binding]; other site 1340495000947 Q-loop/lid; other site 1340495000948 ABC transporter signature motif; other site 1340495000949 Walker B; other site 1340495000950 D-loop; other site 1340495000951 H-loop/switch region; other site 1340495000952 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1340495000953 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1340495000954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1340495000955 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1340495000956 NAD(P) binding site [chemical binding]; other site 1340495000957 active site 1340495000958 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1340495000959 active site 1340495000960 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1340495000961 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1340495000962 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1340495000963 putative transposase OrfB; Reviewed; Region: PHA02517 1340495000964 HTH-like domain; Region: HTH_21; pfam13276 1340495000965 Integrase core domain; Region: rve; pfam00665 1340495000966 Integrase core domain; Region: rve_3; cl15866 1340495000967 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1340495000968 Helix-turn-helix domain; Region: HTH_28; pfam13518 1340495000969 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 1340495000970 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1340495000971 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1340495000972 active site 1340495000973 motif II; other site 1340495000974 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1340495000975 Ferritin-like domain; Region: Ferritin; pfam00210 1340495000976 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1340495000977 dimerization interface [polypeptide binding]; other site 1340495000978 DPS ferroxidase diiron center [ion binding]; other site 1340495000979 ion pore; other site 1340495000980 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1340495000981 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1340495000982 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1340495000983 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1340495000984 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1340495000985 motif II; other site 1340495000986 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1340495000987 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1340495000988 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1340495000989 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1340495000990 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 1340495000991 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1340495000992 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1340495000993 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1340495000994 Walker A/P-loop; other site 1340495000995 ATP binding site [chemical binding]; other site 1340495000996 Q-loop/lid; other site 1340495000997 ABC transporter signature motif; other site 1340495000998 Walker B; other site 1340495000999 D-loop; other site 1340495001000 H-loop/switch region; other site 1340495001001 TOBE domain; Region: TOBE_2; pfam08402 1340495001002 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1340495001003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1340495001004 dimer interface [polypeptide binding]; other site 1340495001005 conserved gate region; other site 1340495001006 putative PBP binding loops; other site 1340495001007 ABC-ATPase subunit interface; other site 1340495001008 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1340495001009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1340495001010 dimer interface [polypeptide binding]; other site 1340495001011 conserved gate region; other site 1340495001012 putative PBP binding loops; other site 1340495001013 ABC-ATPase subunit interface; other site 1340495001014 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1340495001015 benzoate transport; Region: 2A0115; TIGR00895 1340495001016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495001017 putative substrate translocation pore; other site 1340495001018 amino acid transporter; Region: 2A0306; TIGR00909 1340495001019 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1340495001020 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1340495001021 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1340495001022 nudix motif; other site 1340495001023 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1340495001024 catalytic site [active] 1340495001025 G-X2-G-X-G-K; other site 1340495001026 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1340495001027 metal binding site 2 [ion binding]; metal-binding site 1340495001028 putative DNA binding helix; other site 1340495001029 metal binding site 1 [ion binding]; metal-binding site 1340495001030 dimer interface [polypeptide binding]; other site 1340495001031 structural Zn2+ binding site [ion binding]; other site 1340495001032 PspC domain; Region: PspC; pfam04024 1340495001033 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1340495001034 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1340495001035 Predicted membrane protein [Function unknown]; Region: COG1511 1340495001036 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1340495001037 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1340495001038 D-lactate dehydrogenase; Validated; Region: PRK08605 1340495001039 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1340495001040 homodimer interface [polypeptide binding]; other site 1340495001041 ligand binding site [chemical binding]; other site 1340495001042 NAD binding site [chemical binding]; other site 1340495001043 catalytic site [active] 1340495001044 CsbD-like; Region: CsbD; pfam05532 1340495001045 Predicted membrane protein [Function unknown]; Region: COG2261 1340495001046 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1340495001047 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1340495001048 HflX GTPase family; Region: HflX; cd01878 1340495001049 G1 box; other site 1340495001050 GTP/Mg2+ binding site [chemical binding]; other site 1340495001051 Switch I region; other site 1340495001052 G2 box; other site 1340495001053 G3 box; other site 1340495001054 Switch II region; other site 1340495001055 G4 box; other site 1340495001056 G5 box; other site 1340495001057 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1340495001058 catalytic core [active] 1340495001059 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1340495001060 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1340495001061 Part of AAA domain; Region: AAA_19; pfam13245 1340495001062 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 1340495001063 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 1340495001064 EamA-like transporter family; Region: EamA; pfam00892 1340495001065 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1340495001066 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1340495001067 Sulfatase; Region: Sulfatase; pfam00884 1340495001068 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1340495001069 ATP-binding site [chemical binding]; other site 1340495001070 CoA-binding site [chemical binding]; other site 1340495001071 Mg2+-binding site [ion binding]; other site 1340495001072 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1340495001073 AAA domain; Region: AAA_14; pfam13173 1340495001074 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1340495001075 GMP synthase; Reviewed; Region: guaA; PRK00074 1340495001076 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1340495001077 AMP/PPi binding site [chemical binding]; other site 1340495001078 candidate oxyanion hole; other site 1340495001079 catalytic triad [active] 1340495001080 potential glutamine specificity residues [chemical binding]; other site 1340495001081 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1340495001082 ATP Binding subdomain [chemical binding]; other site 1340495001083 Ligand Binding sites [chemical binding]; other site 1340495001084 Dimerization subdomain; other site 1340495001085 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 1340495001086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495001087 putative substrate translocation pore; other site 1340495001088 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1340495001089 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1340495001090 Firmicu-CTERM domain; Region: Firmicu_CTERM; TIGR04145 1340495001091 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495001092 Integrase core domain; Region: rve; pfam00665 1340495001093 Predicted membrane protein [Function unknown]; Region: COG2364 1340495001094 Matrixin; Region: Peptidase_M10; pfam00413 1340495001095 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 1340495001096 active site 1340495001097 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1340495001098 NLPA lipoprotein; Region: Lipoprotein_9; cl19159 1340495001099 HTH-like domain; Region: HTH_21; pfam13276 1340495001100 Integrase core domain; Region: rve; pfam00665 1340495001101 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1340495001102 elongation factor P; Validated; Region: PRK00529 1340495001103 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1340495001104 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1340495001105 RNA binding site [nucleotide binding]; other site 1340495001106 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1340495001107 RNA binding site [nucleotide binding]; other site 1340495001108 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495001109 Integrase core domain; Region: rve; pfam00665 1340495001110 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1340495001111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1340495001112 DNA binding site [nucleotide binding] 1340495001113 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 1340495001114 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1340495001115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1340495001116 dimer interface [polypeptide binding]; other site 1340495001117 conserved gate region; other site 1340495001118 putative PBP binding loops; other site 1340495001119 ABC-ATPase subunit interface; other site 1340495001120 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1340495001121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1340495001122 dimer interface [polypeptide binding]; other site 1340495001123 conserved gate region; other site 1340495001124 putative PBP binding loops; other site 1340495001125 ABC-ATPase subunit interface; other site 1340495001126 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1340495001127 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1340495001128 Walker A/P-loop; other site 1340495001129 ATP binding site [chemical binding]; other site 1340495001130 Q-loop/lid; other site 1340495001131 ABC transporter signature motif; other site 1340495001132 Walker B; other site 1340495001133 D-loop; other site 1340495001134 H-loop/switch region; other site 1340495001135 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1340495001136 PhoU domain; Region: PhoU; pfam01895 1340495001137 PhoU domain; Region: PhoU; pfam01895 1340495001138 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1340495001139 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1340495001140 DXD motif; other site 1340495001141 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1340495001142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1340495001143 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1340495001144 Probable transposase; Region: OrfB_IS605; pfam01385 1340495001145 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1340495001146 N-glycosyltransferase; Provisional; Region: PRK11204 1340495001147 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1340495001148 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1340495001149 dimer interface [polypeptide binding]; other site 1340495001150 NADPH bind site [chemical binding]; other site 1340495001151 FMN binding site [chemical binding]; other site 1340495001152 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495001153 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495001154 Integrase core domain; Region: rve; pfam00665 1340495001155 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 1340495001156 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1340495001157 Cation transport protein; Region: TrkH; cl17365 1340495001158 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1340495001159 Cation transport protein; Region: TrkH; cl17365 1340495001160 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1340495001161 TrkA-N domain; Region: TrkA_N; pfam02254 1340495001162 TrkA-C domain; Region: TrkA_C; pfam02080 1340495001163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1340495001164 manganese transport protein MntH; Reviewed; Region: PRK00701 1340495001165 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1340495001166 Ferrochelatase; Region: Ferrochelatase; pfam00762 1340495001167 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1340495001168 C-terminal domain interface [polypeptide binding]; other site 1340495001169 active site 1340495001170 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1340495001171 active site 1340495001172 N-terminal domain interface [polypeptide binding]; other site 1340495001173 cysteine synthase; Region: PLN02565 1340495001174 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1340495001175 dimer interface [polypeptide binding]; other site 1340495001176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1340495001177 catalytic residue [active] 1340495001178 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1340495001179 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1340495001180 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1340495001181 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 1340495001182 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1340495001183 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1340495001184 ABC transporter; Region: ABC_tran_2; pfam12848 1340495001185 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1340495001186 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1340495001187 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1340495001188 Predicted membrane protein [Function unknown]; Region: COG1288 1340495001189 hypothetical protein; Provisional; Region: PRK07205 1340495001190 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1340495001191 active site 1340495001192 metal binding site [ion binding]; metal-binding site 1340495001193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495001194 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1340495001195 putative substrate translocation pore; other site 1340495001196 sucrose phosphorylase; Provisional; Region: PRK13840 1340495001197 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1340495001198 active site 1340495001199 homodimer interface [polypeptide binding]; other site 1340495001200 catalytic site [active] 1340495001201 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 1340495001202 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495001203 Integrase core domain; Region: rve; pfam00665 1340495001204 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495001205 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1340495001206 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 1340495001207 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1340495001208 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1340495001209 active site 1340495001210 catalytic residues [active] 1340495001211 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1340495001212 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1340495001213 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1340495001214 Probable transposase; Region: OrfB_IS605; pfam01385 1340495001215 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1340495001216 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1340495001217 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1340495001218 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1340495001219 putative NAD(P) binding site [chemical binding]; other site 1340495001220 putative substrate binding site [chemical binding]; other site 1340495001221 catalytic Zn binding site [ion binding]; other site 1340495001222 structural Zn binding site [ion binding]; other site 1340495001223 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1340495001224 active site 1340495001225 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1340495001226 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1340495001227 dimerization interface [polypeptide binding]; other site 1340495001228 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495001229 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495001230 Integrase core domain; Region: rve; pfam00665 1340495001231 malate dehydrogenase; Provisional; Region: PRK13529 1340495001232 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1340495001233 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1340495001234 NAD(P) binding site [chemical binding]; other site 1340495001235 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1340495001236 Class II fumarases; Region: Fumarase_classII; cd01362 1340495001237 active site 1340495001238 tetramer interface [polypeptide binding]; other site 1340495001239 L-aspartate oxidase; Provisional; Region: PRK06175 1340495001240 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1340495001241 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1340495001242 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1340495001243 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1340495001244 NAD binding site [chemical binding]; other site 1340495001245 dimer interface [polypeptide binding]; other site 1340495001246 substrate binding site [chemical binding]; other site 1340495001247 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 1340495001248 anion transporter; Region: dass; TIGR00785 1340495001249 transmembrane helices; other site 1340495001250 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1340495001251 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1340495001252 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1340495001253 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1340495001254 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 1340495001255 NAD(P) binding pocket [chemical binding]; other site 1340495001256 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1340495001257 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1340495001258 active site 1340495001259 nucleotide binding site [chemical binding]; other site 1340495001260 HIGH motif; other site 1340495001261 KMSKS motif; other site 1340495001262 citrate lyase subunit gamma; Provisional; Region: PRK13253 1340495001263 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1340495001264 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1340495001265 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 1340495001266 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 1340495001267 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1340495001268 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1340495001269 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1340495001270 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1340495001271 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1340495001272 dimerization interface [polypeptide binding]; other site 1340495001273 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1340495001274 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1340495001275 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1340495001276 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1340495001277 Fe-S cluster binding site [ion binding]; other site 1340495001278 active site 1340495001279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495001280 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1340495001281 putative substrate translocation pore; other site 1340495001282 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1340495001283 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1340495001284 DJ-1 family protein; Region: not_thiJ; TIGR01383 1340495001285 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1340495001286 conserved cys residue [active] 1340495001287 Predicted integral membrane protein [Function unknown]; Region: COG0392 1340495001288 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1340495001289 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1340495001290 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1340495001291 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1340495001292 active site 1340495001293 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1340495001294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495001295 putative substrate translocation pore; other site 1340495001296 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1340495001297 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1340495001298 DNA binding residues [nucleotide binding] 1340495001299 putative dimer interface [polypeptide binding]; other site 1340495001300 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1340495001301 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1340495001302 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 1340495001303 CAAX protease self-immunity; Region: Abi; pfam02517 1340495001304 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 1340495001305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1340495001306 dimer interface [polypeptide binding]; other site 1340495001307 conserved gate region; other site 1340495001308 putative PBP binding loops; other site 1340495001309 ABC-ATPase subunit interface; other site 1340495001310 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 1340495001311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1340495001312 dimer interface [polypeptide binding]; other site 1340495001313 conserved gate region; other site 1340495001314 putative PBP binding loops; other site 1340495001315 ABC-ATPase subunit interface; other site 1340495001316 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1340495001317 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1340495001318 substrate binding pocket [chemical binding]; other site 1340495001319 membrane-bound complex binding site; other site 1340495001320 hinge residues; other site 1340495001321 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1340495001322 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1340495001323 Walker A/P-loop; other site 1340495001324 ATP binding site [chemical binding]; other site 1340495001325 Q-loop/lid; other site 1340495001326 ABC transporter signature motif; other site 1340495001327 Walker B; other site 1340495001328 D-loop; other site 1340495001329 H-loop/switch region; other site 1340495001330 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1340495001331 Ligand Binding Site [chemical binding]; other site 1340495001332 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1340495001333 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1340495001334 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1340495001335 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1340495001336 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1340495001337 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 1340495001338 FeoA domain; Region: FeoA; pfam04023 1340495001339 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1340495001340 DNA-binding site [nucleotide binding]; DNA binding site 1340495001341 RNA-binding motif; other site 1340495001342 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1340495001343 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1340495001344 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1340495001345 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1340495001346 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1340495001347 active site 1340495001348 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1340495001349 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1340495001350 lysine transporter; Provisional; Region: PRK10836 1340495001351 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1340495001352 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1340495001353 Substrate-binding site [chemical binding]; other site 1340495001354 Substrate specificity [chemical binding]; other site 1340495001355 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1340495001356 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1340495001357 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1340495001358 NAD binding site [chemical binding]; other site 1340495001359 substrate binding site [chemical binding]; other site 1340495001360 catalytic Zn binding site [ion binding]; other site 1340495001361 tetramer interface [polypeptide binding]; other site 1340495001362 structural Zn binding site [ion binding]; other site 1340495001363 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1340495001364 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1340495001365 Clp amino terminal domain; Region: Clp_N; pfam02861 1340495001366 Clp amino terminal domain; Region: Clp_N; pfam02861 1340495001367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495001368 Walker A motif; other site 1340495001369 ATP binding site [chemical binding]; other site 1340495001370 Walker B motif; other site 1340495001371 arginine finger; other site 1340495001372 UvrB/uvrC motif; Region: UVR; pfam02151 1340495001373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495001374 Walker A motif; other site 1340495001375 ATP binding site [chemical binding]; other site 1340495001376 Walker B motif; other site 1340495001377 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1340495001378 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1340495001379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1340495001380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340495001381 ABC transporter signature motif; other site 1340495001382 Walker B; other site 1340495001383 D-loop; other site 1340495001384 H-loop/switch region; other site 1340495001385 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1340495001386 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1340495001387 RPB12 interaction site [polypeptide binding]; other site 1340495001388 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 1340495001389 RPB1 interaction site [polypeptide binding]; other site 1340495001390 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1340495001391 RPB10 interaction site [polypeptide binding]; other site 1340495001392 RPB11 interaction site [polypeptide binding]; other site 1340495001393 RPB3 interaction site [polypeptide binding]; other site 1340495001394 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1340495001395 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 1340495001396 beta and beta' interface [polypeptide binding]; other site 1340495001397 beta' and sigma factor interface [polypeptide binding]; other site 1340495001398 Zn-binding [ion binding]; other site 1340495001399 active site region [active] 1340495001400 catalytic site [active] 1340495001401 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1340495001402 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1340495001403 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1340495001404 G-loop; other site 1340495001405 DNA binding site [nucleotide binding] 1340495001406 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1340495001407 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1340495001408 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1340495001409 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1340495001410 S17 interaction site [polypeptide binding]; other site 1340495001411 S8 interaction site; other site 1340495001412 16S rRNA interaction site [nucleotide binding]; other site 1340495001413 streptomycin interaction site [chemical binding]; other site 1340495001414 23S rRNA interaction site [nucleotide binding]; other site 1340495001415 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1340495001416 30S ribosomal protein S7; Validated; Region: PRK05302 1340495001417 elongation factor G; Reviewed; Region: PRK12739 1340495001418 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1340495001419 G1 box; other site 1340495001420 putative GEF interaction site [polypeptide binding]; other site 1340495001421 GTP/Mg2+ binding site [chemical binding]; other site 1340495001422 Switch I region; other site 1340495001423 G2 box; other site 1340495001424 G3 box; other site 1340495001425 Switch II region; other site 1340495001426 G4 box; other site 1340495001427 G5 box; other site 1340495001428 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1340495001429 Elongation Factor G, domain II; Region: EFG_II; pfam14492 1340495001430 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1340495001431 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1340495001432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1340495001433 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1340495001434 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1340495001435 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1340495001436 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1340495001437 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1340495001438 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1340495001439 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1340495001440 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1340495001441 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1340495001442 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1340495001443 putative translocon binding site; other site 1340495001444 protein-rRNA interface [nucleotide binding]; other site 1340495001445 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1340495001446 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1340495001447 G-X-X-G motif; other site 1340495001448 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1340495001449 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1340495001450 23S rRNA interface [nucleotide binding]; other site 1340495001451 5S rRNA interface [nucleotide binding]; other site 1340495001452 putative antibiotic binding site [chemical binding]; other site 1340495001453 L25 interface [polypeptide binding]; other site 1340495001454 L27 interface [polypeptide binding]; other site 1340495001455 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1340495001456 23S rRNA interface [nucleotide binding]; other site 1340495001457 putative translocon interaction site; other site 1340495001458 signal recognition particle (SRP54) interaction site; other site 1340495001459 L23 interface [polypeptide binding]; other site 1340495001460 trigger factor interaction site; other site 1340495001461 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1340495001462 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1340495001463 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1340495001464 RNA binding site [nucleotide binding]; other site 1340495001465 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1340495001466 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1340495001467 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1340495001468 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1340495001469 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1340495001470 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1340495001471 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1340495001472 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1340495001473 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1340495001474 5S rRNA interface [nucleotide binding]; other site 1340495001475 L27 interface [polypeptide binding]; other site 1340495001476 23S rRNA interface [nucleotide binding]; other site 1340495001477 L5 interface [polypeptide binding]; other site 1340495001478 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1340495001479 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1340495001480 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1340495001481 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1340495001482 23S rRNA binding site [nucleotide binding]; other site 1340495001483 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1340495001484 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1340495001485 SecY translocase; Region: SecY; pfam00344 1340495001486 adenylate kinase; Reviewed; Region: adk; PRK00279 1340495001487 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1340495001488 AMP-binding site [chemical binding]; other site 1340495001489 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1340495001490 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1340495001491 rRNA binding site [nucleotide binding]; other site 1340495001492 predicted 30S ribosome binding site; other site 1340495001493 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1340495001494 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1340495001495 30S ribosomal protein S11; Validated; Region: PRK05309 1340495001496 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1340495001497 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1340495001498 alphaNTD homodimer interface [polypeptide binding]; other site 1340495001499 alphaNTD - beta interaction site [polypeptide binding]; other site 1340495001500 alphaNTD - beta' interaction site [polypeptide binding]; other site 1340495001501 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1340495001502 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1340495001503 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1340495001504 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1340495001505 Walker A/P-loop; other site 1340495001506 ATP binding site [chemical binding]; other site 1340495001507 Q-loop/lid; other site 1340495001508 ABC transporter signature motif; other site 1340495001509 Walker B; other site 1340495001510 D-loop; other site 1340495001511 H-loop/switch region; other site 1340495001512 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1340495001513 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1340495001514 Walker A/P-loop; other site 1340495001515 ATP binding site [chemical binding]; other site 1340495001516 Q-loop/lid; other site 1340495001517 ABC transporter signature motif; other site 1340495001518 Walker B; other site 1340495001519 D-loop; other site 1340495001520 H-loop/switch region; other site 1340495001521 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1340495001522 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1340495001523 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1340495001524 dimerization interface 3.5A [polypeptide binding]; other site 1340495001525 active site 1340495001526 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1340495001527 23S rRNA interface [nucleotide binding]; other site 1340495001528 L3 interface [polypeptide binding]; other site 1340495001529 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1340495001530 acetoin reductase; Validated; Region: PRK08643 1340495001531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1340495001532 NAD(P) binding site [chemical binding]; other site 1340495001533 active site 1340495001534 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1340495001535 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1340495001536 active site 1340495001537 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1340495001538 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1340495001539 Part of AAA domain; Region: AAA_19; pfam13245 1340495001540 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 1340495001541 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1340495001542 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1340495001543 nucleotide binding pocket [chemical binding]; other site 1340495001544 K-X-D-G motif; other site 1340495001545 catalytic site [active] 1340495001546 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1340495001547 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1340495001548 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 1340495001549 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1340495001550 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1340495001551 Dimer interface [polypeptide binding]; other site 1340495001552 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1340495001553 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1340495001554 putative dimer interface [polypeptide binding]; other site 1340495001555 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1340495001556 putative dimer interface [polypeptide binding]; other site 1340495001557 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1340495001558 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1340495001559 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1340495001560 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1340495001561 GatB domain; Region: GatB_Yqey; smart00845 1340495001562 putative lipid kinase; Reviewed; Region: PRK13055 1340495001563 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1340495001564 TRAM domain; Region: TRAM; cl01282 1340495001565 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1340495001566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340495001567 S-adenosylmethionine binding site [chemical binding]; other site 1340495001568 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1340495001569 DNA methylase; Region: N6_N4_Mtase; pfam01555 1340495001570 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 1340495001571 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1340495001572 VRR-NUC domain; Region: VRR_NUC; cl17748 1340495001573 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1340495001574 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1340495001575 ATP binding site [chemical binding]; other site 1340495001576 putative Mg++ binding site [ion binding]; other site 1340495001577 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1340495001578 nucleotide binding region [chemical binding]; other site 1340495001579 ATP-binding site [chemical binding]; other site 1340495001580 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1340495001581 active site 1340495001582 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495001583 Integrase core domain; Region: rve; pfam00665 1340495001584 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1340495001585 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1340495001586 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1340495001587 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1340495001588 metal-binding site [ion binding] 1340495001589 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1340495001590 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1340495001591 ligand binding site [chemical binding]; other site 1340495001592 flexible hinge region; other site 1340495001593 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1340495001594 non-specific DNA interactions [nucleotide binding]; other site 1340495001595 DNA binding site [nucleotide binding] 1340495001596 sequence specific DNA binding site [nucleotide binding]; other site 1340495001597 putative cAMP binding site [chemical binding]; other site 1340495001598 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1340495001599 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495001600 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1340495001601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1340495001602 non-specific DNA binding site [nucleotide binding]; other site 1340495001603 salt bridge; other site 1340495001604 sequence-specific DNA binding site [nucleotide binding]; other site 1340495001605 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1340495001606 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1340495001607 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1340495001608 nucleophilic elbow; other site 1340495001609 catalytic triad; other site 1340495001610 RNA polymerase II elongation factor ELL; Region: ELL; pfam10390 1340495001611 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1340495001612 catalytic triad [active] 1340495001613 conserved cis-peptide bond; other site 1340495001614 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1340495001615 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1340495001616 active site 1340495001617 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1340495001618 nudix motif; other site 1340495001619 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1340495001620 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495001621 Integrase core domain; Region: rve; pfam00665 1340495001622 AAA domain; Region: AAA_22; pfam13401 1340495001623 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1340495001624 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495001625 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495001626 Integrase core domain; Region: rve; pfam00665 1340495001627 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1340495001628 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1340495001629 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1340495001630 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1340495001631 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1340495001632 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 1340495001633 B3/4 domain; Region: B3_4; cl19243 1340495001634 glycerol-3-phosphate dehydrogenase; Provisional; Region: PTZ00345 1340495001635 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1340495001636 FMN binding site [chemical binding]; other site 1340495001637 dimer interface [polypeptide binding]; other site 1340495001638 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1340495001639 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1340495001640 DNA binding site [nucleotide binding] 1340495001641 active site 1340495001642 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1340495001643 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1340495001644 amidase catalytic site [active] 1340495001645 Zn binding residues [ion binding]; other site 1340495001646 substrate binding site [chemical binding]; other site 1340495001647 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1340495001648 LytTr DNA-binding domain; Region: LytTR; smart00850 1340495001649 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1340495001650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1340495001651 Coenzyme A binding pocket [chemical binding]; other site 1340495001652 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1340495001653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1340495001654 Coenzyme A binding pocket [chemical binding]; other site 1340495001655 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 1340495001656 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1340495001657 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1340495001658 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1340495001659 NAD(P) binding site [chemical binding]; other site 1340495001660 LDH/MDH dimer interface [polypeptide binding]; other site 1340495001661 substrate binding site [chemical binding]; other site 1340495001662 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 1340495001663 N-terminal domain from the human glycogen debranching enzyme; Region: hGDE_N; pfam14699 1340495001664 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1340495001665 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1340495001666 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1340495001667 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1340495001668 ATP binding site [chemical binding]; other site 1340495001669 putative Mg++ binding site [ion binding]; other site 1340495001670 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1340495001671 nucleotide binding region [chemical binding]; other site 1340495001672 ATP-binding site [chemical binding]; other site 1340495001673 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1340495001674 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1340495001675 active site 1340495001676 homodimer interface [polypeptide binding]; other site 1340495001677 GtrA-like protein; Region: GtrA; pfam04138 1340495001678 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1340495001679 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1340495001680 active site 1340495001681 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1340495001682 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1340495001683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1340495001684 homodimer interface [polypeptide binding]; other site 1340495001685 catalytic residue [active] 1340495001686 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1340495001687 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1340495001688 inner membrane transporter YjeM; Provisional; Region: PRK15238 1340495001689 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1340495001690 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1340495001691 recombination regulator RecX; Provisional; Region: recX; PRK14135 1340495001692 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1340495001693 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1340495001694 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1340495001695 Ligand binding site; other site 1340495001696 Putative Catalytic site; other site 1340495001697 DXD motif; other site 1340495001698 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1340495001699 Peptidase family M23; Region: Peptidase_M23; pfam01551 1340495001700 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1340495001701 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1340495001702 putative active site [active] 1340495001703 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1340495001704 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1340495001705 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1340495001706 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1340495001707 UDP-galactopyranose mutase; Region: GLF; pfam03275 1340495001708 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1340495001709 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1340495001710 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 1340495001711 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1340495001712 Chain length determinant protein; Region: Wzz; pfam02706 1340495001713 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1340495001714 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1340495001715 Probable Catalytic site; other site 1340495001716 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1340495001717 active site 1340495001718 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1340495001719 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 1340495001720 Probable Catalytic site; other site 1340495001721 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1340495001722 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 1340495001723 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1340495001724 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1340495001725 Ligand binding site; other site 1340495001726 Putative Catalytic site; other site 1340495001727 DXD motif; other site 1340495001728 Predicted integral membrane protein [Function unknown]; Region: COG5542 1340495001729 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1340495001730 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1340495001731 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1340495001732 substrate binding site; other site 1340495001733 tetramer interface; other site 1340495001734 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1340495001735 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1340495001736 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1340495001737 NAD binding site [chemical binding]; other site 1340495001738 substrate binding site [chemical binding]; other site 1340495001739 homodimer interface [polypeptide binding]; other site 1340495001740 active site 1340495001741 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1340495001742 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1340495001743 NADP binding site [chemical binding]; other site 1340495001744 active site 1340495001745 putative substrate binding site [chemical binding]; other site 1340495001746 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1340495001747 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1340495001748 amidase catalytic site [active] 1340495001749 Zn binding residues [ion binding]; other site 1340495001750 substrate binding site [chemical binding]; other site 1340495001751 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1340495001752 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1340495001753 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1340495001754 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1340495001755 G1 box; other site 1340495001756 putative GEF interaction site [polypeptide binding]; other site 1340495001757 GTP/Mg2+ binding site [chemical binding]; other site 1340495001758 Switch I region; other site 1340495001759 G2 box; other site 1340495001760 G3 box; other site 1340495001761 Switch II region; other site 1340495001762 G4 box; other site 1340495001763 G5 box; other site 1340495001764 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1340495001765 Elongation Factor G, domain II; Region: EFG_II; pfam14492 1340495001766 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495001767 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495001768 Integrase core domain; Region: rve; pfam00665 1340495001769 Predicted transcriptional regulators [Transcription]; Region: COG1725 1340495001770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1340495001771 DNA-binding site [nucleotide binding]; DNA binding site 1340495001772 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1340495001773 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1340495001774 Walker A/P-loop; other site 1340495001775 ATP binding site [chemical binding]; other site 1340495001776 Q-loop/lid; other site 1340495001777 ABC transporter signature motif; other site 1340495001778 Walker B; other site 1340495001779 D-loop; other site 1340495001780 H-loop/switch region; other site 1340495001781 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1340495001782 Predicted membrane protein [Function unknown]; Region: COG4684 1340495001783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495001784 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1340495001785 Walker A motif; other site 1340495001786 ATP binding site [chemical binding]; other site 1340495001787 Walker B motif; other site 1340495001788 arginine finger; other site 1340495001789 UvrB/uvrC motif; Region: UVR; pfam02151 1340495001790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495001791 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1340495001792 Walker A motif; other site 1340495001793 ATP binding site [chemical binding]; other site 1340495001794 Walker B motif; other site 1340495001795 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1340495001796 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1340495001797 dimerization domain swap beta strand [polypeptide binding]; other site 1340495001798 regulatory protein interface [polypeptide binding]; other site 1340495001799 active site 1340495001800 regulatory phosphorylation site [posttranslational modification]; other site 1340495001801 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1340495001802 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 1340495001803 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1340495001804 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1340495001805 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1340495001806 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1340495001807 putative ADP-binding pocket [chemical binding]; other site 1340495001808 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1340495001809 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1340495001810 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1340495001811 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 1340495001812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1340495001813 Coenzyme A binding pocket [chemical binding]; other site 1340495001814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495001815 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1340495001816 putative substrate translocation pore; other site 1340495001817 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1340495001818 ATP cone domain; Region: ATP-cone; pfam03477 1340495001819 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1340495001820 effector binding site; other site 1340495001821 active site 1340495001822 Zn binding site [ion binding]; other site 1340495001823 glycine loop; other site 1340495001824 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1340495001825 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1340495001826 FeS/SAM binding site; other site 1340495001827 Uncharacterized protein family (UPF0051); Region: UPF0051; cl19515 1340495001828 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1340495001829 RNA polymerase I-specific transcription-initiation factor; Region: Rrn6; pfam10214 1340495001830 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1340495001831 active site 1340495001832 metal-binding site [ion binding] 1340495001833 nucleotide-binding site [chemical binding]; other site 1340495001834 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1340495001835 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1340495001836 active site 1340495001837 putative catalytic site [active] 1340495001838 DNA binding site [nucleotide binding] 1340495001839 putative phosphate binding site [ion binding]; other site 1340495001840 metal binding site A [ion binding]; metal-binding site 1340495001841 AP binding site [nucleotide binding]; other site 1340495001842 metal binding site B [ion binding]; metal-binding site 1340495001843 putative glutamate synthase subunit beta; Provisional; Region: PRK12770 1340495001844 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1340495001845 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1340495001846 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1340495001847 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1340495001848 homodimer interface [polypeptide binding]; other site 1340495001849 active site 1340495001850 FMN binding site [chemical binding]; other site 1340495001851 substrate binding site [chemical binding]; other site 1340495001852 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 1340495001853 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1340495001854 active site 1340495001855 catalytic tetrad [active] 1340495001856 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1340495001857 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1340495001858 putative dimer interface [polypeptide binding]; other site 1340495001859 DNA polymerase IV; Reviewed; Region: PRK03103 1340495001860 Y-family of DNA polymerases; Region: PolY; cl12025 1340495001861 active site 1340495001862 DNA binding site [nucleotide binding] 1340495001863 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1340495001864 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1340495001865 VanZ like family; Region: VanZ; cl01971 1340495001866 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1340495001867 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1340495001868 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1340495001869 metal binding site 2 [ion binding]; metal-binding site 1340495001870 putative DNA binding helix; other site 1340495001871 metal binding site 1 [ion binding]; metal-binding site 1340495001872 dimer interface [polypeptide binding]; other site 1340495001873 structural Zn2+ binding site [ion binding]; other site 1340495001874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495001875 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1340495001876 putative substrate translocation pore; other site 1340495001877 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1340495001878 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1340495001879 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1340495001880 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1340495001881 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1340495001882 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1340495001883 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1340495001884 active site 1340495001885 HIGH motif; other site 1340495001886 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1340495001887 KMSKS motif; other site 1340495001888 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1340495001889 tRNA binding surface [nucleotide binding]; other site 1340495001890 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1340495001891 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1340495001892 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1340495001893 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1340495001894 putative substrate binding site [chemical binding]; other site 1340495001895 putative ATP binding site [chemical binding]; other site 1340495001896 dipeptidase PepV; Reviewed; Region: PRK07318 1340495001897 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1340495001898 active site 1340495001899 metal binding site [ion binding]; metal-binding site 1340495001900 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1340495001901 Ligand Binding Site [chemical binding]; other site 1340495001902 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1340495001903 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1340495001904 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1340495001905 Substrate-binding site [chemical binding]; other site 1340495001906 Substrate specificity [chemical binding]; other site 1340495001907 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1340495001908 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1340495001909 DNA binding site [nucleotide binding] 1340495001910 domain linker motif; other site 1340495001911 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1340495001912 dimerization interface [polypeptide binding]; other site 1340495001913 ligand binding site [chemical binding]; other site 1340495001914 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1340495001915 substrate binding site [chemical binding]; other site 1340495001916 dimer interface [polypeptide binding]; other site 1340495001917 ATP binding site [chemical binding]; other site 1340495001918 CAAX protease self-immunity; Region: Abi; pfam02517 1340495001919 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 1340495001920 The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain; Region: ASCH; smart01022 1340495001921 Dihydroneopterin aldolase; Region: FolB; pfam02152 1340495001922 active site 1340495001923 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1340495001924 catalytic center binding site [active] 1340495001925 ATP binding site [chemical binding]; other site 1340495001926 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1340495001927 active site 1340495001928 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1340495001929 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1340495001930 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1340495001931 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1340495001932 active site 1340495001933 dimerization interface [polypeptide binding]; other site 1340495001934 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 1340495001935 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1340495001936 substrate binding pocket [chemical binding]; other site 1340495001937 dimer interface [polypeptide binding]; other site 1340495001938 inhibitor binding site; inhibition site 1340495001939 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1340495001940 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1340495001941 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1340495001942 NAD binding site [chemical binding]; other site 1340495001943 dimer interface [polypeptide binding]; other site 1340495001944 substrate binding site [chemical binding]; other site 1340495001945 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1340495001946 dimer interface [polypeptide binding]; other site 1340495001947 substrate binding site [chemical binding]; other site 1340495001948 ATP binding site [chemical binding]; other site 1340495001949 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1340495001950 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1340495001951 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1340495001952 active site 1340495001953 HIGH motif; other site 1340495001954 KMSK motif region; other site 1340495001955 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1340495001956 tRNA binding surface [nucleotide binding]; other site 1340495001957 anticodon binding site; other site 1340495001958 Transglycosylase; Region: Transgly; pfam00912 1340495001959 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1340495001960 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1340495001961 Protein of unknown function (DUF964); Region: DUF964; cl01483 1340495001962 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1340495001963 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1340495001964 active site 1340495001965 metal binding site [ion binding]; metal-binding site 1340495001966 DNA binding site [nucleotide binding] 1340495001967 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1340495001968 AAA domain; Region: AAA_23; pfam13476 1340495001969 Walker A/P-loop; other site 1340495001970 ATP binding site [chemical binding]; other site 1340495001971 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1340495001972 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1340495001973 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1340495001974 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1340495001975 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 1340495001976 HIT family signature motif; other site 1340495001977 catalytic residue [active] 1340495001978 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1340495001979 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1340495001980 Walker A/P-loop; other site 1340495001981 ATP binding site [chemical binding]; other site 1340495001982 Q-loop/lid; other site 1340495001983 ABC transporter signature motif; other site 1340495001984 Walker B; other site 1340495001985 D-loop; other site 1340495001986 H-loop/switch region; other site 1340495001987 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1340495001988 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1340495001989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340495001990 S-adenosylmethionine binding site [chemical binding]; other site 1340495001991 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1340495001992 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1340495001993 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1340495001994 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1340495001995 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1340495001996 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1340495001997 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 1340495001998 active site 1340495001999 catalytic tetrad [active] 1340495002000 glutaminase A; Region: Gln_ase; TIGR03814 1340495002001 Predicted small secreted protein [Function unknown]; Region: COG5584 1340495002002 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1340495002003 catalytic residues [active] 1340495002004 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 1340495002005 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1340495002006 putative tRNA-binding site [nucleotide binding]; other site 1340495002007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1340495002008 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1340495002009 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1340495002010 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1340495002011 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1340495002012 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1340495002013 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1340495002014 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1340495002015 DNA polymerase I; Provisional; Region: PRK05755 1340495002016 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1340495002017 active site 1340495002018 metal binding site 1 [ion binding]; metal-binding site 1340495002019 putative 5' ssDNA interaction site; other site 1340495002020 metal binding site 3; metal-binding site 1340495002021 metal binding site 2 [ion binding]; metal-binding site 1340495002022 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1340495002023 putative DNA binding site [nucleotide binding]; other site 1340495002024 putative metal binding site [ion binding]; other site 1340495002025 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1340495002026 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1340495002027 active site 1340495002028 DNA binding site [nucleotide binding] 1340495002029 catalytic site [active] 1340495002030 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1340495002031 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1340495002032 DNA binding site [nucleotide binding] 1340495002033 catalytic residue [active] 1340495002034 H2TH interface [polypeptide binding]; other site 1340495002035 putative catalytic residues [active] 1340495002036 turnover-facilitating residue; other site 1340495002037 intercalation triad [nucleotide binding]; other site 1340495002038 8OG recognition residue [nucleotide binding]; other site 1340495002039 putative reading head residues; other site 1340495002040 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1340495002041 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1340495002042 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1340495002043 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1340495002044 CoA-binding site [chemical binding]; other site 1340495002045 ATP-binding [chemical binding]; other site 1340495002046 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1340495002047 ATP cone domain; Region: ATP-cone; pfam03477 1340495002048 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1340495002049 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1340495002050 primosomal protein DnaI; Reviewed; Region: PRK08939 1340495002051 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1340495002052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495002053 Walker A motif; other site 1340495002054 ATP binding site [chemical binding]; other site 1340495002055 Walker B motif; other site 1340495002056 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1340495002057 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1340495002058 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1340495002059 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1340495002060 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1340495002061 23S rRNA binding site [nucleotide binding]; other site 1340495002062 L21 binding site [polypeptide binding]; other site 1340495002063 L13 binding site [polypeptide binding]; other site 1340495002064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1340495002065 active site 1340495002066 motif I; other site 1340495002067 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1340495002068 motif II; other site 1340495002069 GTPase YqeH; Provisional; Region: PRK13796 1340495002070 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1340495002071 GTP/Mg2+ binding site [chemical binding]; other site 1340495002072 G4 box; other site 1340495002073 G5 box; other site 1340495002074 G1 box; other site 1340495002075 Switch I region; other site 1340495002076 G2 box; other site 1340495002077 G3 box; other site 1340495002078 Switch II region; other site 1340495002079 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1340495002080 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1340495002081 active site 1340495002082 (T/H)XGH motif; other site 1340495002083 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1340495002084 Zn2+ binding site [ion binding]; other site 1340495002085 Mg2+ binding site [ion binding]; other site 1340495002086 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1340495002087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340495002088 S-adenosylmethionine binding site [chemical binding]; other site 1340495002089 hypothetical protein; Provisional; Region: PRK13670 1340495002090 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1340495002091 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1340495002092 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1340495002093 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1340495002094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1340495002095 active site 1340495002096 phosphorylation site [posttranslational modification] 1340495002097 intermolecular recognition site; other site 1340495002098 dimerization interface [polypeptide binding]; other site 1340495002099 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1340495002100 DNA binding site [nucleotide binding] 1340495002101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1340495002102 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1340495002103 dimerization interface [polypeptide binding]; other site 1340495002104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1340495002105 dimer interface [polypeptide binding]; other site 1340495002106 phosphorylation site [posttranslational modification] 1340495002107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1340495002108 ATP binding site [chemical binding]; other site 1340495002109 Mg2+ binding site [ion binding]; other site 1340495002110 G-X-G motif; other site 1340495002111 inner membrane transporter YjeM; Provisional; Region: PRK15238 1340495002112 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1340495002113 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1340495002114 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1340495002115 active site 1340495002116 catalytic residues [active] 1340495002117 metal binding site [ion binding]; metal-binding site 1340495002118 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1340495002119 OxaA-like protein precursor; Provisional; Region: PRK02463 1340495002120 Acylphosphatase; Region: Acylphosphatase; pfam00708 1340495002121 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1340495002122 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1340495002123 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1340495002124 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1340495002125 Predicted transcriptional regulators [Transcription]; Region: COG1733 1340495002126 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1340495002127 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1340495002128 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1340495002129 dimer interface [polypeptide binding]; other site 1340495002130 motif 1; other site 1340495002131 active site 1340495002132 motif 2; other site 1340495002133 motif 3; other site 1340495002134 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1340495002135 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1340495002136 putative tRNA-binding site [nucleotide binding]; other site 1340495002137 B3/4 domain; Region: B3_4; pfam03483 1340495002138 tRNA synthetase B5 domain; Region: B5; smart00874 1340495002139 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1340495002140 dimer interface [polypeptide binding]; other site 1340495002141 motif 1; other site 1340495002142 motif 3; other site 1340495002143 motif 2; other site 1340495002144 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1340495002145 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1340495002146 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1340495002147 NlpC/P60 family; Region: NLPC_P60; pfam00877 1340495002148 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1340495002149 ATP-binding site [chemical binding]; other site 1340495002150 Sugar specificity; other site 1340495002151 Pyrimidine base specificity; other site 1340495002152 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1340495002153 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1340495002154 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1340495002155 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1340495002156 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1340495002157 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1340495002158 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1340495002159 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 1340495002160 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1340495002161 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1340495002162 Rhomboid family; Region: Rhomboid; cl11446 1340495002163 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1340495002164 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1340495002165 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1340495002166 nucleotide binding site [chemical binding]; other site 1340495002167 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1340495002168 active site residue [active] 1340495002169 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 1340495002170 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1340495002171 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1340495002172 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1340495002173 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1340495002174 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1340495002175 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1340495002176 active site 1340495002177 HIGH motif; other site 1340495002178 KMSKS motif; other site 1340495002179 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1340495002180 aminotransferase A; Validated; Region: PRK07683 1340495002181 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1340495002182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1340495002183 homodimer interface [polypeptide binding]; other site 1340495002184 catalytic residue [active] 1340495002185 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1340495002186 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1340495002187 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1340495002188 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1340495002189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1340495002190 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 1340495002191 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1340495002192 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1340495002193 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1340495002194 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1340495002195 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1340495002196 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1340495002197 catalytic residue [active] 1340495002198 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1340495002199 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1340495002200 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1340495002201 active site 1340495002202 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1340495002203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1340495002204 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1340495002205 putative RNA binding site [nucleotide binding]; other site 1340495002206 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1340495002207 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1340495002208 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1340495002209 homodimer interface [polypeptide binding]; other site 1340495002210 NADP binding site [chemical binding]; other site 1340495002211 substrate binding site [chemical binding]; other site 1340495002212 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1340495002213 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1340495002214 generic binding surface II; other site 1340495002215 generic binding surface I; other site 1340495002216 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1340495002217 nucleotide binding site [chemical binding]; other site 1340495002218 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1340495002219 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1340495002220 substrate binding pocket [chemical binding]; other site 1340495002221 chain length determination region; other site 1340495002222 substrate-Mg2+ binding site; other site 1340495002223 catalytic residues [active] 1340495002224 aspartate-rich region 1; other site 1340495002225 active site lid residues [active] 1340495002226 aspartate-rich region 2; other site 1340495002227 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1340495002228 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1340495002229 RNA binding surface [nucleotide binding]; other site 1340495002230 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1340495002231 Arginine repressor [Transcription]; Region: ArgR; COG1438 1340495002232 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1340495002233 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1340495002234 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1340495002235 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1340495002236 Walker A/P-loop; other site 1340495002237 ATP binding site [chemical binding]; other site 1340495002238 Q-loop/lid; other site 1340495002239 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1340495002240 ABC transporter signature motif; other site 1340495002241 Walker B; other site 1340495002242 D-loop; other site 1340495002243 H-loop/switch region; other site 1340495002244 Guanylate kinase; Region: Guanylate_kin; pfam00625 1340495002245 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1340495002246 catalytic site [active] 1340495002247 G-X2-G-X-G-K; other site 1340495002248 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1340495002249 Flavoprotein; Region: Flavoprotein; cl19190 1340495002250 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1340495002251 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 1340495002252 primosome assembly protein PriA; Validated; Region: PRK05580 1340495002253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1340495002254 ATP binding site [chemical binding]; other site 1340495002255 putative Mg++ binding site [ion binding]; other site 1340495002256 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1340495002257 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1340495002258 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1340495002259 putative active site [active] 1340495002260 substrate binding site [chemical binding]; other site 1340495002261 putative cosubstrate binding site; other site 1340495002262 catalytic site [active] 1340495002263 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1340495002264 substrate binding site [chemical binding]; other site 1340495002265 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1340495002266 NusB family; Region: NusB; pfam01029 1340495002267 putative RNA binding site [nucleotide binding]; other site 1340495002268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340495002269 S-adenosylmethionine binding site [chemical binding]; other site 1340495002270 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1340495002271 active site 1340495002272 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1340495002273 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1340495002274 substrate binding site [chemical binding]; other site 1340495002275 activation loop (A-loop); other site 1340495002276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1340495002277 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1340495002278 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1340495002279 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1340495002280 GTPase RsgA; Reviewed; Region: PRK00098 1340495002281 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1340495002282 RNA binding site [nucleotide binding]; other site 1340495002283 homodimer interface [polypeptide binding]; other site 1340495002284 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1340495002285 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1340495002286 GTP/Mg2+ binding site [chemical binding]; other site 1340495002287 G4 box; other site 1340495002288 G5 box; other site 1340495002289 G1 box; other site 1340495002290 Switch I region; other site 1340495002291 G2 box; other site 1340495002292 G3 box; other site 1340495002293 Switch II region; other site 1340495002294 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1340495002295 substrate binding site [chemical binding]; other site 1340495002296 hexamer interface [polypeptide binding]; other site 1340495002297 metal binding site [ion binding]; metal-binding site 1340495002298 Thiamine pyrophosphokinase; Region: TPK; cd07995 1340495002299 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1340495002300 active site 1340495002301 dimerization interface [polypeptide binding]; other site 1340495002302 thiamine binding site [chemical binding]; other site 1340495002303 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1340495002304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1340495002305 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1340495002306 DAK2 domain; Region: Dak2; pfam02734 1340495002307 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 1340495002308 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1340495002309 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1340495002310 generic binding surface II; other site 1340495002311 ssDNA binding site; other site 1340495002312 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1340495002313 ATP binding site [chemical binding]; other site 1340495002314 putative Mg++ binding site [ion binding]; other site 1340495002315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1340495002316 nucleotide binding region [chemical binding]; other site 1340495002317 ATP-binding site [chemical binding]; other site 1340495002318 putative phosphate acyltransferase; Provisional; Region: PRK05331 1340495002319 acyl carrier protein; Provisional; Region: acpP; PRK00982 1340495002320 ribonuclease III; Reviewed; Region: rnc; PRK00102 1340495002321 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1340495002322 dimerization interface [polypeptide binding]; other site 1340495002323 active site 1340495002324 metal binding site [ion binding]; metal-binding site 1340495002325 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1340495002326 dsRNA binding site [nucleotide binding]; other site 1340495002327 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1340495002328 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1340495002329 Walker A/P-loop; other site 1340495002330 ATP binding site [chemical binding]; other site 1340495002331 Q-loop/lid; other site 1340495002332 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 1340495002333 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1340495002334 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 1340495002335 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1340495002336 ABC transporter signature motif; other site 1340495002337 Walker B; other site 1340495002338 D-loop; other site 1340495002339 H-loop/switch region; other site 1340495002340 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1340495002341 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1340495002342 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1340495002343 P loop; other site 1340495002344 GTP binding site [chemical binding]; other site 1340495002345 putative DNA-binding protein; Validated; Region: PRK00118 1340495002346 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1340495002347 signal recognition particle protein; Provisional; Region: PRK10867 1340495002348 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1340495002349 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1340495002350 P loop; other site 1340495002351 GTP binding site [chemical binding]; other site 1340495002352 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1340495002353 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1340495002354 KH domain; Region: KH_4; pfam13083 1340495002355 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1340495002356 RimM N-terminal domain; Region: RimM; pfam01782 1340495002357 PRC-barrel domain; Region: PRC; pfam05239 1340495002358 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1340495002359 amino acid transporter; Region: 2A0306; TIGR00909 1340495002360 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1340495002361 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1340495002362 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1340495002363 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540 1340495002364 putative metal binding site [ion binding]; other site 1340495002365 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1340495002366 active site 1340495002367 putative catalytic site [active] 1340495002368 DNA binding site [nucleotide binding] 1340495002369 putative phosphate binding site [ion binding]; other site 1340495002370 metal binding site A [ion binding]; metal-binding site 1340495002371 AP binding site [nucleotide binding]; other site 1340495002372 metal binding site B [ion binding]; metal-binding site 1340495002373 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1340495002374 Helix-turn-helix domain; Region: HTH_28; pfam13518 1340495002375 putative transposase OrfB; Reviewed; Region: PHA02517 1340495002376 HTH-like domain; Region: HTH_21; pfam13276 1340495002377 Integrase core domain; Region: rve; pfam00665 1340495002378 Integrase core domain; Region: rve_3; pfam13683 1340495002379 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1340495002380 substrate binding pocket [chemical binding]; other site 1340495002381 chain length determination region; other site 1340495002382 substrate-Mg2+ binding site; other site 1340495002383 catalytic residues [active] 1340495002384 aspartate-rich region 1; other site 1340495002385 active site lid residues [active] 1340495002386 aspartate-rich region 2; other site 1340495002387 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 1340495002388 putative active site [active] 1340495002389 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1340495002390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340495002391 S-adenosylmethionine binding site [chemical binding]; other site 1340495002392 drug efflux system protein MdtG; Provisional; Region: PRK09874 1340495002393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495002394 putative substrate translocation pore; other site 1340495002395 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1340495002396 active site 1340495002397 metal binding site [ion binding]; metal-binding site 1340495002398 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1340495002399 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1340495002400 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1340495002401 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1340495002402 peroxiredoxin; Region: AhpC; TIGR03137 1340495002403 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1340495002404 dimer interface [polypeptide binding]; other site 1340495002405 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1340495002406 catalytic triad [active] 1340495002407 peroxidatic and resolving cysteines [active] 1340495002408 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 1340495002409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1340495002410 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1340495002411 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1340495002412 catalytic residue [active] 1340495002413 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1340495002414 catalytic residues [active] 1340495002415 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1340495002416 MucBP domain; Region: MucBP; pfam06458 1340495002417 MucBP domain; Region: MucBP; pfam06458 1340495002418 MucBP domain; Region: MucBP; pfam06458 1340495002419 large tegument protein UL36; Provisional; Region: PHA03247 1340495002420 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1340495002421 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1340495002422 accessory Sec system translocase SecY2; Region: acc_sec_Y2; TIGR02920 1340495002423 SecY translocase; Region: SecY; pfam00344 1340495002424 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 1340495002425 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1340495002426 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 1340495002427 Accessory Sec secretory system ASP3; Region: Sec-ASP3; cl14014 1340495002428 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 1340495002429 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1340495002430 ATP binding site [chemical binding]; other site 1340495002431 putative Mg++ binding site [ion binding]; other site 1340495002432 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1340495002433 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 1340495002434 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1340495002435 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1340495002436 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1340495002437 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 1340495002438 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1340495002439 Protein of unknown function (DUF515); Region: DUF515; cl19548 1340495002440 Uncharacterized conserved protein (DUF2217); Region: DUF2217; pfam10265 1340495002441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495002442 Walker A motif; other site 1340495002443 ATP binding site [chemical binding]; other site 1340495002444 Walker B motif; other site 1340495002445 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1340495002446 Integrase core domain; Region: rve; pfam00665 1340495002447 Peptidase family C69; Region: Peptidase_C69; cl17793 1340495002448 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1340495002449 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1340495002450 TrkA-N domain; Region: TrkA_N; pfam02254 1340495002451 TrkA-C domain; Region: TrkA_C; pfam02080 1340495002452 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 1340495002453 active site 1 [active] 1340495002454 dimer interface [polypeptide binding]; other site 1340495002455 hexamer interface [polypeptide binding]; other site 1340495002456 active site 2 [active] 1340495002457 glycerol kinase; Provisional; Region: glpK; PRK00047 1340495002458 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1340495002459 N- and C-terminal domain interface [polypeptide binding]; other site 1340495002460 active site 1340495002461 MgATP binding site [chemical binding]; other site 1340495002462 catalytic site [active] 1340495002463 metal binding site [ion binding]; metal-binding site 1340495002464 glycerol binding site [chemical binding]; other site 1340495002465 homotetramer interface [polypeptide binding]; other site 1340495002466 homodimer interface [polypeptide binding]; other site 1340495002467 FBP binding site [chemical binding]; other site 1340495002468 protein IIAGlc interface [polypeptide binding]; other site 1340495002469 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1340495002470 Homeodomain-like domain; Region: HTH_23; pfam13384 1340495002471 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1340495002472 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1340495002473 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1340495002474 Probable transposase; Region: OrfB_IS605; pfam01385 1340495002475 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1340495002476 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1340495002477 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1340495002478 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 1340495002479 Chain length determinant protein; Region: Wzz; pfam02706 1340495002480 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1340495002481 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1340495002482 AAA domain; Region: AAA_31; pfam13614 1340495002483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1340495002484 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1340495002485 NAD(P) binding site [chemical binding]; other site 1340495002486 active site 1340495002487 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1340495002488 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1340495002489 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1340495002490 active site 1340495002491 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1340495002492 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1340495002493 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1340495002494 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1340495002495 active site 1340495002496 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1340495002497 active site 1340495002498 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1340495002499 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1340495002500 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1340495002501 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1340495002502 active site 1340495002503 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1340495002504 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1340495002505 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1340495002506 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1340495002507 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495002508 Integrase core domain; Region: rve; pfam00665 1340495002509 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; cl19952 1340495002510 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1340495002511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1340495002512 NAD(P) binding site [chemical binding]; other site 1340495002513 active site 1340495002514 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1340495002515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1340495002516 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1340495002517 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1340495002518 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 1340495002519 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1340495002520 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1340495002521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1340495002522 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 1340495002523 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1340495002524 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1340495002525 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1340495002526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1340495002527 Helix-turn-helix domain; Region: HTH_28; pfam13518 1340495002528 HTH-like domain; Region: HTH_21; pfam13276 1340495002529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1340495002530 Integrase core domain; Region: rve; pfam00665 1340495002531 transposase; Provisional; Region: PRK06526 1340495002532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495002533 Walker A motif; other site 1340495002534 ATP binding site [chemical binding]; other site 1340495002535 Walker B motif; other site 1340495002536 arginine finger; other site 1340495002537 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1340495002538 Integrase core domain; Region: rve; pfam00665 1340495002539 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1340495002540 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1340495002541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495002542 Walker A motif; other site 1340495002543 ATP binding site [chemical binding]; other site 1340495002544 Walker B motif; other site 1340495002545 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1340495002546 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1340495002547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1340495002548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1340495002549 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1340495002550 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495002551 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495002552 Integrase core domain; Region: rve; pfam00665 1340495002553 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495002554 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495002555 Integrase core domain; Region: rve; pfam00665 1340495002556 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1340495002557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1340495002558 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1340495002559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1340495002560 Integrase core domain; Region: rve; pfam00665 1340495002561 transposase/IS protein; Provisional; Region: PRK09183 1340495002562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495002563 Walker A motif; other site 1340495002564 ATP binding site [chemical binding]; other site 1340495002565 Walker B motif; other site 1340495002566 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1340495002567 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 1340495002568 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1340495002569 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1340495002570 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1340495002571 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1340495002572 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 1340495002573 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1340495002574 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1340495002575 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1340495002576 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1340495002577 S-methylmethionine transporter; Provisional; Region: PRK11387 1340495002578 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1340495002579 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1340495002580 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1340495002581 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1340495002582 Probable transposase; Region: OrfB_IS605; pfam01385 1340495002583 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1340495002584 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1340495002585 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 1340495002586 Rib/alpha-like repeat; Region: Rib; cl07159 1340495002587 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1340495002588 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1340495002589 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1340495002590 ATP binding site [chemical binding]; other site 1340495002591 putative Mg++ binding site [ion binding]; other site 1340495002592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1340495002593 nucleotide binding region [chemical binding]; other site 1340495002594 ATP-binding site [chemical binding]; other site 1340495002595 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1340495002596 PHP domain; Region: PHP; pfam02811 1340495002597 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1340495002598 active site 1340495002599 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1340495002600 Bacterial SH3 domain; Region: SH3_5; pfam08460 1340495002601 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1340495002602 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1340495002603 active site 1340495002604 metal binding site [ion binding]; metal-binding site 1340495002605 DNA binding site [nucleotide binding] 1340495002606 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1340495002607 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1340495002608 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1340495002609 Walker A/P-loop; other site 1340495002610 ATP binding site [chemical binding]; other site 1340495002611 Q-loop/lid; other site 1340495002612 Protein of unknown function (DUF342); Region: DUF342; cl19219 1340495002613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340495002614 ABC transporter signature motif; other site 1340495002615 Walker B; other site 1340495002616 D-loop; other site 1340495002617 H-loop/switch region; other site 1340495002618 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495002619 Integrase core domain; Region: rve; pfam00665 1340495002620 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495002621 Bacterial lipoprotein; Region: DUF3642; pfam12182 1340495002622 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1340495002623 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1340495002624 active site 1340495002625 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1340495002626 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 1340495002627 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 1340495002628 trimer interface [polypeptide binding]; other site 1340495002629 active site 1340495002630 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 1340495002631 catalytic site [active] 1340495002632 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1340495002633 putative ion selectivity filter; other site 1340495002634 putative pore gating glutamate residue; other site 1340495002635 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1340495002636 thiamine phosphate binding site [chemical binding]; other site 1340495002637 active site 1340495002638 pyrophosphate binding site [ion binding]; other site 1340495002639 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1340495002640 dimer interface [polypeptide binding]; other site 1340495002641 substrate binding site [chemical binding]; other site 1340495002642 ATP binding site [chemical binding]; other site 1340495002643 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1340495002644 substrate binding site [chemical binding]; other site 1340495002645 multimerization interface [polypeptide binding]; other site 1340495002646 ATP binding site [chemical binding]; other site 1340495002647 DNA polymerase III, alpha chain, Gram-positive type; Region: polC_Gram_pos; TIGR01405 1340495002648 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495002649 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495002650 Integrase core domain; Region: rve; pfam00665 1340495002651 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1340495002652 putative ligand binding residues [chemical binding]; other site 1340495002653 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1340495002654 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1340495002655 Helix-turn-helix domain; Region: HTH_28; pfam13518 1340495002656 putative transposase OrfB; Reviewed; Region: PHA02517 1340495002657 HTH-like domain; Region: HTH_21; pfam13276 1340495002658 Integrase core domain; Region: rve; pfam00665 1340495002659 Integrase core domain; Region: rve_3; pfam13683 1340495002660 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1340495002661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340495002662 Walker A/P-loop; other site 1340495002663 ATP binding site [chemical binding]; other site 1340495002664 Q-loop/lid; other site 1340495002665 ABC transporter signature motif; other site 1340495002666 Walker B; other site 1340495002667 D-loop; other site 1340495002668 H-loop/switch region; other site 1340495002669 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1340495002670 ABC-ATPase subunit interface; other site 1340495002671 dimer interface [polypeptide binding]; other site 1340495002672 putative PBP binding regions; other site 1340495002673 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1340495002674 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1340495002675 MoaE homodimer interface [polypeptide binding]; other site 1340495002676 MoaD interaction [polypeptide binding]; other site 1340495002677 active site residues [active] 1340495002678 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1340495002679 MoaE interaction surface [polypeptide binding]; other site 1340495002680 MoeB interaction surface [polypeptide binding]; other site 1340495002681 thiocarboxylated glycine; other site 1340495002682 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1340495002683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495002684 putative substrate translocation pore; other site 1340495002685 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1340495002686 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1340495002687 DNA binding residues [nucleotide binding] 1340495002688 dimerization interface [polypeptide binding]; other site 1340495002689 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1340495002690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1340495002691 active site 1340495002692 phosphorylation site [posttranslational modification] 1340495002693 intermolecular recognition site; other site 1340495002694 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1340495002695 Histidine kinase; Region: HisKA_3; pfam07730 1340495002696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1340495002697 ATP binding site [chemical binding]; other site 1340495002698 Mg2+ binding site [ion binding]; other site 1340495002699 G-X-G motif; other site 1340495002700 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1340495002701 active site 1340495002702 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 1340495002703 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1340495002704 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1340495002705 dimer interface [polypeptide binding]; other site 1340495002706 putative functional site; other site 1340495002707 putative MPT binding site; other site 1340495002708 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1340495002709 MPT binding site; other site 1340495002710 trimer interface [polypeptide binding]; other site 1340495002711 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1340495002712 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1340495002713 ATP binding site [chemical binding]; other site 1340495002714 substrate interface [chemical binding]; other site 1340495002715 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1340495002716 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 1340495002717 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1340495002718 [4Fe-4S] binding site [ion binding]; other site 1340495002719 molybdopterin cofactor binding site [chemical binding]; other site 1340495002720 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1340495002721 molybdopterin cofactor binding site; other site 1340495002722 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1340495002723 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1340495002724 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 1340495002725 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1340495002726 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1340495002727 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1340495002728 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 1340495002729 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1340495002730 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1340495002731 EamA-like transporter family; Region: EamA; pfam00892 1340495002732 EamA-like transporter family; Region: EamA; pfam00892 1340495002733 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1340495002734 active site 1340495002735 DNA binding site [nucleotide binding] 1340495002736 Int/Topo IB signature motif; other site 1340495002737 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1340495002738 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1340495002739 active site 1340495002740 nucleophile elbow; other site 1340495002741 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1340495002742 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1340495002743 active site 1340495002744 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236 1340495002745 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1340495002746 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1340495002747 active site 1340495002748 DNA binding site [nucleotide binding] 1340495002749 Int/Topo IB signature motif; other site 1340495002750 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1340495002751 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1340495002752 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1340495002753 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1340495002754 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1340495002755 dimer interface [polypeptide binding]; other site 1340495002756 active site 1340495002757 CoA binding pocket [chemical binding]; other site 1340495002758 acyl carrier protein; Provisional; Region: acpP; PRK00982 1340495002759 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1340495002760 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1340495002761 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1340495002762 NAD(P) binding site [chemical binding]; other site 1340495002763 homotetramer interface [polypeptide binding]; other site 1340495002764 homodimer interface [polypeptide binding]; other site 1340495002765 active site 1340495002766 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1340495002767 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1340495002768 dimer interface [polypeptide binding]; other site 1340495002769 active site 1340495002770 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1340495002771 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1340495002772 carboxyltransferase (CT) interaction site; other site 1340495002773 biotinylation site [posttranslational modification]; other site 1340495002774 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1340495002775 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1340495002776 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1340495002777 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1340495002778 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1340495002779 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 1340495002780 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 1340495002781 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1340495002782 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1340495002783 NAD binding site [chemical binding]; other site 1340495002784 homotetramer interface [polypeptide binding]; other site 1340495002785 homodimer interface [polypeptide binding]; other site 1340495002786 substrate binding site [chemical binding]; other site 1340495002787 active site 1340495002788 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495002789 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495002790 Integrase core domain; Region: rve; pfam00665 1340495002791 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1340495002792 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1340495002793 putative active site [active] 1340495002794 putative NTP binding site [chemical binding]; other site 1340495002795 putative nucleic acid binding site [nucleotide binding]; other site 1340495002796 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1340495002797 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1340495002798 catalytic residues [active] 1340495002799 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 1340495002800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1340495002801 salt bridge; other site 1340495002802 non-specific DNA binding site [nucleotide binding]; other site 1340495002803 sequence-specific DNA binding site [nucleotide binding]; other site 1340495002804 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1340495002805 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 1340495002806 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1340495002807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1340495002808 active site 1340495002809 motif I; other site 1340495002810 motif II; other site 1340495002811 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 1340495002812 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1340495002813 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1340495002814 Predicted membrane protein [Function unknown]; Region: COG2323 1340495002815 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 1340495002816 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1340495002817 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1340495002818 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1340495002819 putative active site [active] 1340495002820 catalytic site [active] 1340495002821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495002822 Walker A motif; other site 1340495002823 ATP binding site [chemical binding]; other site 1340495002824 Walker B motif; other site 1340495002825 arginine finger; other site 1340495002826 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1340495002827 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1340495002828 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1340495002829 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1340495002830 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 1340495002831 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1340495002832 TPP-binding site; other site 1340495002833 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1340495002834 PYR/PP interface [polypeptide binding]; other site 1340495002835 dimer interface [polypeptide binding]; other site 1340495002836 TPP binding site [chemical binding]; other site 1340495002837 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1340495002838 AAA domain; Region: AAA_22; pfam13401 1340495002839 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1340495002840 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1340495002841 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1340495002842 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1340495002843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340495002844 Walker A/P-loop; other site 1340495002845 ATP binding site [chemical binding]; other site 1340495002846 Q-loop/lid; other site 1340495002847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340495002848 ABC transporter signature motif; other site 1340495002849 Walker B; other site 1340495002850 D-loop; other site 1340495002851 H-loop/switch region; other site 1340495002852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340495002853 Walker A/P-loop; other site 1340495002854 ATP binding site [chemical binding]; other site 1340495002855 Q-loop/lid; other site 1340495002856 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1340495002857 ABC transporter signature motif; other site 1340495002858 Walker B; other site 1340495002859 D-loop; other site 1340495002860 H-loop/switch region; other site 1340495002861 CrcB-like protein; Region: CRCB; pfam02537 1340495002862 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1340495002863 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1340495002864 dimer interface [polypeptide binding]; other site 1340495002865 metal binding site [ion binding]; metal-binding site 1340495002866 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1340495002867 putative active site [active] 1340495002868 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1340495002869 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1340495002870 Domain of unknown function DUF21; Region: DUF21; pfam01595 1340495002871 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1340495002872 Transporter associated domain; Region: CorC_HlyC; pfam03471 1340495002873 Penicillinase repressor; Region: Penicillinase_R; cl17580 1340495002874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495002875 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1340495002876 putative substrate translocation pore; other site 1340495002877 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1340495002878 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1340495002879 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1340495002880 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1340495002881 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1340495002882 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1340495002883 dimerization interface [polypeptide binding]; other site 1340495002884 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1340495002885 active site 1340495002886 catalytic tetrad [active] 1340495002887 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1340495002888 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1340495002889 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1340495002890 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1340495002891 Coenzyme A binding pocket [chemical binding]; other site 1340495002892 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1340495002893 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 1340495002894 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1340495002895 Ligand binding site; other site 1340495002896 metal-binding site 1340495002897 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1340495002898 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1340495002899 Probable transposase; Region: OrfB_IS605; pfam01385 1340495002900 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1340495002901 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1340495002902 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1340495002903 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1340495002904 EDD domain protein, DegV family; Region: DegV; TIGR00762 1340495002905 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1340495002906 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1340495002907 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1340495002908 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 1340495002909 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1340495002910 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 1340495002911 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1340495002912 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1340495002913 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1340495002914 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1340495002915 catalytic site [active] 1340495002916 subunit interface [polypeptide binding]; other site 1340495002917 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1340495002918 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1340495002919 RNA binding surface [nucleotide binding]; other site 1340495002920 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1340495002921 active site 1340495002922 lipoprotein signal peptidase; Provisional; Region: PRK14797 1340495002923 ATP-dependent protease Lon; Provisional; Region: PRK13765 1340495002924 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 1340495002925 RNA/DNA hybrid binding site [nucleotide binding]; other site 1340495002926 active site 1340495002927 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1340495002928 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1340495002929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1340495002930 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 1340495002931 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495002932 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495002933 Integrase core domain; Region: rve; pfam00665 1340495002934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1340495002935 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1340495002936 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1340495002937 cell division protein GpsB; Provisional; Region: PRK14127 1340495002938 hypothetical protein; Provisional; Region: PRK13660 1340495002939 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1340495002940 Transglycosylase; Region: Transgly; pfam00912 1340495002941 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1340495002942 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1340495002943 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1340495002944 EamA-like transporter family; Region: EamA; pfam00892 1340495002945 EamA-like transporter family; Region: EamA; pfam00892 1340495002946 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1340495002947 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1340495002948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1340495002949 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1340495002950 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1340495002951 active site 1340495002952 catalytic site [active] 1340495002953 substrate binding site [chemical binding]; other site 1340495002954 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1340495002955 AAA domain; Region: AAA_22; pfam13401 1340495002956 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1340495002957 mevalonate kinase; Region: mevalon_kin; TIGR00549 1340495002958 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1340495002959 diphosphomevalonate decarboxylase; Region: PLN02407 1340495002960 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1340495002961 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1340495002962 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1340495002963 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1340495002964 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1340495002965 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1340495002966 homotetramer interface [polypeptide binding]; other site 1340495002967 FMN binding site [chemical binding]; other site 1340495002968 homodimer contacts [polypeptide binding]; other site 1340495002969 putative active site [active] 1340495002970 putative substrate binding site [chemical binding]; other site 1340495002971 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 1340495002972 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1340495002973 Melibiase; Region: Melibiase; pfam02065 1340495002974 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1340495002975 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1340495002976 DNA binding site [nucleotide binding] 1340495002977 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1340495002978 putative dimerization interface [polypeptide binding]; other site 1340495002979 putative ligand binding site [chemical binding]; other site 1340495002980 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1340495002981 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1340495002982 nucleotide binding site [chemical binding]; other site 1340495002983 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1340495002984 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1340495002985 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1340495002986 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1340495002987 NAD binding site [chemical binding]; other site 1340495002988 dimer interface [polypeptide binding]; other site 1340495002989 substrate binding site [chemical binding]; other site 1340495002990 LrgB-like family; Region: LrgB; cl00596 1340495002991 LrgA family; Region: LrgA; cl00608 1340495002992 two-component response regulator; Provisional; Region: PRK14084 1340495002993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1340495002994 active site 1340495002995 phosphorylation site [posttranslational modification] 1340495002996 intermolecular recognition site; other site 1340495002997 dimerization interface [polypeptide binding]; other site 1340495002998 LytTr DNA-binding domain; Region: LytTR; pfam04397 1340495002999 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1340495003000 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1340495003001 GAF domain; Region: GAF_3; pfam13492 1340495003002 Histidine kinase; Region: His_kinase; pfam06580 1340495003003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1340495003004 ATP binding site [chemical binding]; other site 1340495003005 Mg2+ binding site [ion binding]; other site 1340495003006 G-X-G motif; other site 1340495003007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1340495003008 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u2; cd03402 1340495003009 prohibitin homologues; Region: PHB; smart00244 1340495003010 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1340495003011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340495003012 S-adenosylmethionine binding site [chemical binding]; other site 1340495003013 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1340495003014 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1340495003015 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1340495003016 active site 1340495003017 motif I; other site 1340495003018 motif II; other site 1340495003019 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 1340495003020 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 1340495003021 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1340495003022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1340495003023 active site 1340495003024 phosphorylation site [posttranslational modification] 1340495003025 intermolecular recognition site; other site 1340495003026 dimerization interface [polypeptide binding]; other site 1340495003027 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1340495003028 DNA binding residues [nucleotide binding] 1340495003029 dimerization interface [polypeptide binding]; other site 1340495003030 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1340495003031 non-specific DNA binding site [nucleotide binding]; other site 1340495003032 salt bridge; other site 1340495003033 sequence-specific DNA binding site [nucleotide binding]; other site 1340495003034 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1340495003035 FeS assembly protein SufB; Region: sufB; TIGR01980 1340495003036 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1340495003037 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1340495003038 trimerization site [polypeptide binding]; other site 1340495003039 active site 1340495003040 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1340495003041 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1340495003042 catalytic residue [active] 1340495003043 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1340495003044 FeS assembly protein SufD; Region: sufD; TIGR01981 1340495003045 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1340495003046 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1340495003047 Walker A/P-loop; other site 1340495003048 ATP binding site [chemical binding]; other site 1340495003049 Q-loop/lid; other site 1340495003050 ABC transporter signature motif; other site 1340495003051 Walker B; other site 1340495003052 D-loop; other site 1340495003053 H-loop/switch region; other site 1340495003054 FeoA domain; Region: FeoA; pfam04023 1340495003055 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1340495003056 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1340495003057 G1 box; other site 1340495003058 GTP/Mg2+ binding site [chemical binding]; other site 1340495003059 Switch I region; other site 1340495003060 G2 box; other site 1340495003061 G3 box; other site 1340495003062 Switch II region; other site 1340495003063 G4 box; other site 1340495003064 G5 box; other site 1340495003065 Nucleoside recognition; Region: Gate; pfam07670 1340495003066 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1340495003067 Nucleoside recognition; Region: Gate; pfam07670 1340495003068 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1340495003069 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1340495003070 acyl-activating enzyme (AAE) consensus motif; other site 1340495003071 putative AMP binding site [chemical binding]; other site 1340495003072 putative active site [active] 1340495003073 putative CoA binding site [chemical binding]; other site 1340495003074 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 1340495003075 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1340495003076 substrate binding site [chemical binding]; other site 1340495003077 oxyanion hole (OAH) forming residues; other site 1340495003078 trimer interface [polypeptide binding]; other site 1340495003079 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1340495003080 CoenzymeA binding site [chemical binding]; other site 1340495003081 subunit interaction site [polypeptide binding]; other site 1340495003082 PHB binding site; other site 1340495003083 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1340495003084 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1340495003085 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1340495003086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495003087 D-galactonate transporter; Region: 2A0114; TIGR00893 1340495003088 putative substrate translocation pore; other site 1340495003089 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 1340495003090 Ion transport protein; Region: Ion_trans; pfam00520 1340495003091 Ion channel; Region: Ion_trans_2; pfam07885 1340495003092 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1340495003093 homopentamer interface [polypeptide binding]; other site 1340495003094 active site 1340495003095 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1340495003096 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1340495003097 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1340495003098 dimerization interface [polypeptide binding]; other site 1340495003099 active site 1340495003100 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1340495003101 Lumazine binding domain; Region: Lum_binding; pfam00677 1340495003102 Lumazine binding domain; Region: Lum_binding; pfam00677 1340495003103 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1340495003104 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1340495003105 catalytic motif [active] 1340495003106 Zn binding site [ion binding]; other site 1340495003107 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1340495003108 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1340495003109 active site 1340495003110 tetramer interface [polypeptide binding]; other site 1340495003111 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 1340495003112 homodimer interface [polypeptide binding]; other site 1340495003113 putative active site [active] 1340495003114 catalytic site [active] 1340495003115 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1340495003116 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1340495003117 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1340495003118 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1340495003119 ATP binding site [chemical binding]; other site 1340495003120 putative Mg++ binding site [ion binding]; other site 1340495003121 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1340495003122 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1340495003123 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1340495003124 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1340495003125 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1340495003126 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1340495003127 active site 1340495003128 Int/Topo IB signature motif; other site 1340495003129 DNA binding site [nucleotide binding] 1340495003130 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1340495003131 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1340495003132 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1340495003133 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1340495003134 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1340495003135 Protein of unknown function DUF262; Region: DUF262; pfam03235 1340495003136 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1340495003137 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1340495003138 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 1340495003139 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1340495003140 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 1340495003141 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1340495003142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1340495003143 Coenzyme A binding pocket [chemical binding]; other site 1340495003144 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1340495003145 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1340495003146 N- and C-terminal domain interface [polypeptide binding]; other site 1340495003147 active site 1340495003148 catalytic site [active] 1340495003149 metal binding site [ion binding]; metal-binding site 1340495003150 carbohydrate binding site [chemical binding]; other site 1340495003151 ATP binding site [chemical binding]; other site 1340495003152 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1340495003153 GntP family permease; Region: GntP_permease; pfam02447 1340495003154 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1340495003155 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1340495003156 DNA binding site [nucleotide binding] 1340495003157 domain linker motif; other site 1340495003158 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1340495003159 putative dimerization interface [polypeptide binding]; other site 1340495003160 putative ligand binding site [chemical binding]; other site 1340495003161 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1340495003162 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1340495003163 N- and C-terminal domain interface [polypeptide binding]; other site 1340495003164 active site 1340495003165 catalytic site [active] 1340495003166 metal binding site [ion binding]; metal-binding site 1340495003167 carbohydrate binding site [chemical binding]; other site 1340495003168 ATP binding site [chemical binding]; other site 1340495003169 Asp23 family; Region: Asp23; pfam03780 1340495003170 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1340495003171 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1340495003172 Coenzyme A binding pocket [chemical binding]; other site 1340495003173 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; pfam01521 1340495003174 Helix-turn-helix domain; Region: HTH_28; pfam13518 1340495003175 putative transposase OrfB; Reviewed; Region: PHA02517 1340495003176 HTH-like domain; Region: HTH_21; pfam13276 1340495003177 Integrase core domain; Region: rve; pfam00665 1340495003178 Integrase core domain; Region: rve_3; pfam13683 1340495003179 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1340495003180 DHH family; Region: DHH; pfam01368 1340495003181 DHHA2 domain; Region: DHHA2; pfam02833 1340495003182 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1340495003183 nudix motif; other site 1340495003184 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1340495003185 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1340495003186 CAP-like domain; other site 1340495003187 active site 1340495003188 primary dimer interface [polypeptide binding]; other site 1340495003189 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1340495003190 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1340495003191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1340495003192 ATP binding site [chemical binding]; other site 1340495003193 Mg2+ binding site [ion binding]; other site 1340495003194 G-X-G motif; other site 1340495003195 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1340495003196 anchoring element; other site 1340495003197 dimer interface [polypeptide binding]; other site 1340495003198 ATP binding site [chemical binding]; other site 1340495003199 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1340495003200 active site 1340495003201 metal binding site [ion binding]; metal-binding site 1340495003202 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1340495003203 membrane protein; Provisional; Region: PRK14392 1340495003204 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1340495003205 active site 1340495003206 catalytic residues [active] 1340495003207 DNA topoisomerase I; Validated; Region: PRK05582 1340495003208 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1340495003209 active site 1340495003210 interdomain interaction site; other site 1340495003211 putative metal-binding site [ion binding]; other site 1340495003212 nucleotide binding site [chemical binding]; other site 1340495003213 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1340495003214 domain I; other site 1340495003215 DNA binding groove [nucleotide binding] 1340495003216 phosphate binding site [ion binding]; other site 1340495003217 domain II; other site 1340495003218 domain III; other site 1340495003219 nucleotide binding site [chemical binding]; other site 1340495003220 catalytic site [active] 1340495003221 domain IV; other site 1340495003222 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1340495003223 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1340495003224 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1340495003225 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1340495003226 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1340495003227 RNA/DNA hybrid binding site [nucleotide binding]; other site 1340495003228 active site 1340495003229 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 1340495003230 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1340495003231 GTP/Mg2+ binding site [chemical binding]; other site 1340495003232 G4 box; other site 1340495003233 G5 box; other site 1340495003234 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1340495003235 G1 box; other site 1340495003236 G1 box; other site 1340495003237 GTP/Mg2+ binding site [chemical binding]; other site 1340495003238 Switch I region; other site 1340495003239 G2 box; other site 1340495003240 G2 box; other site 1340495003241 G3 box; other site 1340495003242 G3 box; other site 1340495003243 Switch II region; other site 1340495003244 Switch II region; other site 1340495003245 G4 box; other site 1340495003246 hypothetical protein; Provisional; Region: PRK13672 1340495003247 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1340495003248 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1340495003249 active site 1340495003250 catalytic triad [active] 1340495003251 oxyanion hole [active] 1340495003252 EDD domain protein, DegV family; Region: DegV; TIGR00762 1340495003253 Haemolysin-III related; Region: HlyIII; cl03831 1340495003254 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1340495003255 folate binding site [chemical binding]; other site 1340495003256 NADP+ binding site [chemical binding]; other site 1340495003257 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1340495003258 dimerization interface [polypeptide binding]; other site 1340495003259 active site 1340495003260 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1340495003261 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1340495003262 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340495003263 ABC transporter; Region: ABC_tran_2; pfam12848 1340495003264 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1340495003265 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1340495003266 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1340495003267 active site 1340495003268 NTP binding site [chemical binding]; other site 1340495003269 metal binding triad [ion binding]; metal-binding site 1340495003270 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1340495003271 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1340495003272 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1340495003273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1340495003274 binding surface 1340495003275 TPR motif; other site 1340495003276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1340495003277 TPR motif; other site 1340495003278 binding surface 1340495003279 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1340495003280 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1340495003281 TPR motif; other site 1340495003282 binding surface 1340495003283 Tetratricopeptide repeat; Region: TPR_19; pfam14559 1340495003284 histone-like DNA-binding protein HU; Region: HU; cd13831 1340495003285 dimer interface [polypeptide binding]; other site 1340495003286 DNA binding site [nucleotide binding] 1340495003287 GTP-binding protein Der; Reviewed; Region: PRK00093 1340495003288 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1340495003289 G1 box; other site 1340495003290 GTP/Mg2+ binding site [chemical binding]; other site 1340495003291 Switch I region; other site 1340495003292 G2 box; other site 1340495003293 Switch II region; other site 1340495003294 G3 box; other site 1340495003295 G4 box; other site 1340495003296 G5 box; other site 1340495003297 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1340495003298 G1 box; other site 1340495003299 GTP/Mg2+ binding site [chemical binding]; other site 1340495003300 Switch I region; other site 1340495003301 G2 box; other site 1340495003302 G3 box; other site 1340495003303 Switch II region; other site 1340495003304 G4 box; other site 1340495003305 G5 box; other site 1340495003306 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 1340495003307 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1340495003308 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1340495003309 RNA binding site [nucleotide binding]; other site 1340495003310 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1340495003311 RNA binding site [nucleotide binding]; other site 1340495003312 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1340495003313 RNA binding site [nucleotide binding]; other site 1340495003314 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1340495003315 RNA binding site [nucleotide binding]; other site 1340495003316 cytidylate kinase; Provisional; Region: cmk; PRK00023 1340495003317 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1340495003318 CMP-binding site; other site 1340495003319 The sites determining sugar specificity; other site 1340495003320 ATP-dependent DNA helicase, RecQ family; Region: recQ_fam; TIGR00614 1340495003321 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1340495003322 ATP binding site [chemical binding]; other site 1340495003323 putative Mg++ binding site [ion binding]; other site 1340495003324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1340495003325 nucleotide binding region [chemical binding]; other site 1340495003326 ATP-binding site [chemical binding]; other site 1340495003327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1340495003328 Helix-turn-helix domain; Region: HTH_40; pfam14493 1340495003329 Predicted membrane protein [Function unknown]; Region: COG3601 1340495003330 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1340495003331 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1340495003332 RNA binding surface [nucleotide binding]; other site 1340495003333 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1340495003334 active site 1340495003335 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1340495003336 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1340495003337 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1340495003338 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1340495003339 active site 1340495003340 DNA binding site [nucleotide binding] 1340495003341 Int/Topo IB signature motif; other site 1340495003342 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1340495003343 S1 domain; Region: S1_2; pfam13509 1340495003344 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1340495003345 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1340495003346 domain interfaces; other site 1340495003347 active site 1340495003348 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1340495003349 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1340495003350 active site 1340495003351 PHP Thumb interface [polypeptide binding]; other site 1340495003352 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1340495003353 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 1340495003354 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1340495003355 generic binding surface II; other site 1340495003356 generic binding surface I; other site 1340495003357 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1340495003358 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1340495003359 peptidase T-like protein; Region: PepT-like; TIGR01883 1340495003360 metal binding site [ion binding]; metal-binding site 1340495003361 dimer interface [polypeptide binding]; other site 1340495003362 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1340495003363 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1340495003364 aminotransferase A; Validated; Region: PRK07683 1340495003365 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1340495003366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1340495003367 homodimer interface [polypeptide binding]; other site 1340495003368 catalytic residue [active] 1340495003369 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1340495003370 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1340495003371 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1340495003372 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1340495003373 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1340495003374 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1340495003375 DNA binding residues [nucleotide binding] 1340495003376 DNA primase; Validated; Region: dnaG; PRK05667 1340495003377 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1340495003378 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1340495003379 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1340495003380 active site 1340495003381 metal binding site [ion binding]; metal-binding site 1340495003382 interdomain interaction site; other site 1340495003383 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1340495003384 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1340495003385 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 1340495003386 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1340495003387 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1340495003388 dimer interface [polypeptide binding]; other site 1340495003389 motif 1; other site 1340495003390 active site 1340495003391 motif 2; other site 1340495003392 motif 3; other site 1340495003393 Recombination protein O N terminal; Region: RecO_N; pfam11967 1340495003394 DNA repair protein RecO; Region: reco; TIGR00613 1340495003395 Recombination protein O C terminal; Region: RecO_C; pfam02565 1340495003396 GTPase Era; Reviewed; Region: era; PRK00089 1340495003397 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1340495003398 G1 box; other site 1340495003399 GTP/Mg2+ binding site [chemical binding]; other site 1340495003400 Switch I region; other site 1340495003401 G2 box; other site 1340495003402 Switch II region; other site 1340495003403 G3 box; other site 1340495003404 G4 box; other site 1340495003405 G5 box; other site 1340495003406 KH domain; Region: KH_2; pfam07650 1340495003407 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 1340495003408 trimer interface [polypeptide binding]; other site 1340495003409 putative active site [active] 1340495003410 Zn binding site [ion binding]; other site 1340495003411 metal-binding heat shock protein; Provisional; Region: PRK00016 1340495003412 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1340495003413 PhoH-like protein; Region: PhoH; pfam02562 1340495003414 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1340495003415 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1340495003416 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1340495003417 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1340495003418 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1340495003419 argininosuccinate lyase; Provisional; Region: PRK00855 1340495003420 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1340495003421 active sites [active] 1340495003422 tetramer interface [polypeptide binding]; other site 1340495003423 Arginosuccinate synthase; Region: Arginosuc_synth; cl17227 1340495003424 Arginosuccinate synthase; Region: Arginosuc_synth; cl17227 1340495003425 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1340495003426 active site 1340495003427 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495003428 Integrase core domain; Region: rve; pfam00665 1340495003429 Yqey-like protein; Region: YqeY; pfam09424 1340495003430 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1340495003431 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1340495003432 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1340495003433 substrate binding pocket [chemical binding]; other site 1340495003434 membrane-bound complex binding site; other site 1340495003435 hinge residues; other site 1340495003436 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 1340495003437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1340495003438 dimer interface [polypeptide binding]; other site 1340495003439 conserved gate region; other site 1340495003440 putative PBP binding loops; other site 1340495003441 ABC-ATPase subunit interface; other site 1340495003442 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1340495003443 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1340495003444 Walker A/P-loop; other site 1340495003445 ATP binding site [chemical binding]; other site 1340495003446 Q-loop/lid; other site 1340495003447 ABC transporter signature motif; other site 1340495003448 Walker B; other site 1340495003449 D-loop; other site 1340495003450 H-loop/switch region; other site 1340495003451 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1340495003452 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1340495003453 dimer interface [polypeptide binding]; other site 1340495003454 anticodon binding site; other site 1340495003455 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1340495003456 homodimer interface [polypeptide binding]; other site 1340495003457 motif 1; other site 1340495003458 active site 1340495003459 motif 2; other site 1340495003460 GAD domain; Region: GAD; pfam02938 1340495003461 motif 3; other site 1340495003462 Phosphotransferase enzyme family; Region: APH; pfam01636 1340495003463 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1340495003464 active site 1340495003465 substrate binding site [chemical binding]; other site 1340495003466 ATP binding site [chemical binding]; other site 1340495003467 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1340495003468 putative active site [active] 1340495003469 dimerization interface [polypeptide binding]; other site 1340495003470 putative tRNAtyr binding site [nucleotide binding]; other site 1340495003471 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1340495003472 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1340495003473 Zn2+ binding site [ion binding]; other site 1340495003474 Mg2+ binding site [ion binding]; other site 1340495003475 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1340495003476 synthetase active site [active] 1340495003477 NTP binding site [chemical binding]; other site 1340495003478 metal binding site [ion binding]; metal-binding site 1340495003479 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1340495003480 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1340495003481 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1340495003482 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1340495003483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340495003484 S-adenosylmethionine binding site [chemical binding]; other site 1340495003485 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1340495003486 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1340495003487 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1340495003488 NAD binding site [chemical binding]; other site 1340495003489 dimer interface [polypeptide binding]; other site 1340495003490 substrate binding site [chemical binding]; other site 1340495003491 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1340495003492 Peptidase family C69; Region: Peptidase_C69; pfam03577 1340495003493 GTP-binding protein LepA; Provisional; Region: PRK05433 1340495003494 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1340495003495 G1 box; other site 1340495003496 putative GEF interaction site [polypeptide binding]; other site 1340495003497 GTP/Mg2+ binding site [chemical binding]; other site 1340495003498 Switch I region; other site 1340495003499 G2 box; other site 1340495003500 G3 box; other site 1340495003501 Switch II region; other site 1340495003502 G4 box; other site 1340495003503 G5 box; other site 1340495003504 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1340495003505 Elongation Factor G, domain II; Region: EFG_II; pfam14492 1340495003506 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1340495003507 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1340495003508 chaperone protein DnaJ; Provisional; Region: PRK14276 1340495003509 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1340495003510 HSP70 interaction site [polypeptide binding]; other site 1340495003511 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1340495003512 substrate binding site [polypeptide binding]; other site 1340495003513 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1340495003514 Zn binding sites [ion binding]; other site 1340495003515 dimer interface [polypeptide binding]; other site 1340495003516 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1340495003517 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1340495003518 nucleotide binding site [chemical binding]; other site 1340495003519 NEF interaction site [polypeptide binding]; other site 1340495003520 SBD interface [polypeptide binding]; other site 1340495003521 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1340495003522 dimer interface [polypeptide binding]; other site 1340495003523 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1340495003524 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1340495003525 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1340495003526 HrcA protein C terminal domain; Region: HrcA; pfam01628 1340495003527 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495003528 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495003529 Integrase core domain; Region: rve; pfam00665 1340495003530 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495003531 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495003532 Integrase core domain; Region: rve; pfam00665 1340495003533 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1340495003534 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1340495003535 active site 1340495003536 Riboflavin kinase; Region: Flavokinase; smart00904 1340495003537 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1340495003538 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1340495003539 RNA binding site [nucleotide binding]; other site 1340495003540 active site 1340495003541 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1340495003542 translation initiation factor IF-2; Validated; Region: infB; PRK05306 1340495003543 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1340495003544 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1340495003545 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1340495003546 G1 box; other site 1340495003547 putative GEF interaction site [polypeptide binding]; other site 1340495003548 GTP/Mg2+ binding site [chemical binding]; other site 1340495003549 Switch I region; other site 1340495003550 G2 box; other site 1340495003551 G3 box; other site 1340495003552 Switch II region; other site 1340495003553 G4 box; other site 1340495003554 G5 box; other site 1340495003555 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1340495003556 Translation-initiation factor 2; Region: IF-2; pfam11987 1340495003557 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1340495003558 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1340495003559 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1340495003560 putative RNA binding cleft [nucleotide binding]; other site 1340495003561 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1340495003562 NusA N-terminal domain; Region: NusA_N; pfam08529 1340495003563 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1340495003564 RNA binding site [nucleotide binding]; other site 1340495003565 homodimer interface [polypeptide binding]; other site 1340495003566 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1340495003567 G-X-X-G motif; other site 1340495003568 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1340495003569 G-X-X-G motif; other site 1340495003570 Sm and related proteins; Region: Sm_like; cl00259 1340495003571 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1340495003572 putative oligomer interface [polypeptide binding]; other site 1340495003573 putative RNA binding site [nucleotide binding]; other site 1340495003574 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1340495003575 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 1340495003576 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 1340495003577 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1340495003578 generic binding surface II; other site 1340495003579 generic binding surface I; other site 1340495003580 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1340495003581 active site 1340495003582 putative PHP Thumb interface [polypeptide binding]; other site 1340495003583 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1340495003584 active site 1340495003585 catalytic site [active] 1340495003586 substrate binding site [chemical binding]; other site 1340495003587 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1340495003588 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 1340495003589 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1340495003590 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1340495003591 dimer interface [polypeptide binding]; other site 1340495003592 motif 1; other site 1340495003593 active site 1340495003594 motif 2; other site 1340495003595 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1340495003596 putative deacylase active site [active] 1340495003597 motif 3; other site 1340495003598 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1340495003599 anticodon binding site; other site 1340495003600 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1340495003601 RIP metalloprotease RseP; Region: TIGR00054 1340495003602 active site 1340495003603 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1340495003604 protein binding site [polypeptide binding]; other site 1340495003605 putative substrate binding region [chemical binding]; other site 1340495003606 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1340495003607 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 1340495003608 active site 1340495003609 dimer interface [polypeptide binding]; other site 1340495003610 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1340495003611 hinge region; other site 1340495003612 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1340495003613 putative nucleotide binding site [chemical binding]; other site 1340495003614 uridine monophosphate binding site [chemical binding]; other site 1340495003615 homohexameric interface [polypeptide binding]; other site 1340495003616 elongation factor Ts; Provisional; Region: tsf; PRK09377 1340495003617 UBA/TS-N domain; Region: UBA; pfam00627 1340495003618 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1340495003619 rRNA interaction site [nucleotide binding]; other site 1340495003620 S8 interaction site; other site 1340495003621 putative laminin-1 binding site; other site 1340495003622 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1340495003623 D-lactate dehydrogenase; Validated; Region: PRK08605 1340495003624 homodimer interface [polypeptide binding]; other site 1340495003625 ligand binding site [chemical binding]; other site 1340495003626 NAD binding site [chemical binding]; other site 1340495003627 catalytic site [active] 1340495003628 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1340495003629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340495003630 S-adenosylmethionine binding site [chemical binding]; other site 1340495003631 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1340495003632 putative acyl-acceptor binding pocket; other site 1340495003633 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 1340495003634 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1340495003635 LexA repressor; Validated; Region: PRK00215 1340495003636 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1340495003637 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1340495003638 Catalytic site [active] 1340495003639 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1340495003640 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1340495003641 dimer interface [polypeptide binding]; other site 1340495003642 active site 1340495003643 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 1340495003644 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 1340495003645 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1340495003646 RNA/DNA hybrid binding site [nucleotide binding]; other site 1340495003647 active site 1340495003648 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 1340495003649 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1340495003650 active site 1340495003651 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1340495003652 DHH family; Region: DHH; pfam01368 1340495003653 DHHA1 domain; Region: DHHA1; pfam02272 1340495003654 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1340495003655 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1340495003656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1340495003657 NAD(P) binding site [chemical binding]; other site 1340495003658 active site 1340495003659 ribonuclease Z; Region: RNase_Z; TIGR02651 1340495003660 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1340495003661 GTP1/OBG; Region: GTP1_OBG; pfam01018 1340495003662 Obg GTPase; Region: Obg; cd01898 1340495003663 G1 box; other site 1340495003664 GTP/Mg2+ binding site [chemical binding]; other site 1340495003665 Switch I region; other site 1340495003666 G2 box; other site 1340495003667 G3 box; other site 1340495003668 Switch II region; other site 1340495003669 G4 box; other site 1340495003670 G5 box; other site 1340495003671 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1340495003672 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1340495003673 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1340495003674 GIY-YIG motif/motif A; other site 1340495003675 active site 1340495003676 catalytic site [active] 1340495003677 putative DNA binding site [nucleotide binding]; other site 1340495003678 metal binding site [ion binding]; metal-binding site 1340495003679 UvrB/uvrC motif; Region: UVR; pfam02151 1340495003680 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1340495003681 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 1340495003682 DNA binding site [nucleotide binding] 1340495003683 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 1340495003684 putative metal binding site [ion binding]; other site 1340495003685 Predicted GTPase [General function prediction only]; Region: COG0218 1340495003686 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1340495003687 G1 box; other site 1340495003688 GTP/Mg2+ binding site [chemical binding]; other site 1340495003689 Switch I region; other site 1340495003690 G2 box; other site 1340495003691 G3 box; other site 1340495003692 Switch II region; other site 1340495003693 G4 box; other site 1340495003694 G5 box; other site 1340495003695 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1340495003696 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1340495003697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495003698 Walker A motif; other site 1340495003699 ATP binding site [chemical binding]; other site 1340495003700 Walker B motif; other site 1340495003701 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1340495003702 trigger factor; Provisional; Region: tig; PRK01490 1340495003703 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 1340495003704 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1340495003705 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1340495003706 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1340495003707 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1340495003708 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1340495003709 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1340495003710 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1340495003711 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1340495003712 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495003713 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495003714 Integrase core domain; Region: rve; pfam00665 1340495003715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1340495003716 Integrase core domain; Region: rve; pfam00665 1340495003717 transposase; Provisional; Region: PRK06526 1340495003718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495003719 Walker A motif; other site 1340495003720 ATP binding site [chemical binding]; other site 1340495003721 Walker B motif; other site 1340495003722 arginine finger; other site 1340495003723 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495003724 Integrase core domain; Region: rve; pfam00665 1340495003725 elongation factor Tu; Reviewed; Region: PRK12736 1340495003726 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1340495003727 G1 box; other site 1340495003728 GEF interaction site [polypeptide binding]; other site 1340495003729 GTP/Mg2+ binding site [chemical binding]; other site 1340495003730 Switch I region; other site 1340495003731 G2 box; other site 1340495003732 G3 box; other site 1340495003733 Switch II region; other site 1340495003734 G4 box; other site 1340495003735 G5 box; other site 1340495003736 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1340495003737 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1340495003738 Antibiotic Binding Site [chemical binding]; other site 1340495003739 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1340495003740 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1340495003741 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 1340495003742 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1340495003743 16S/18S rRNA binding site [nucleotide binding]; other site 1340495003744 S13e-L30e interaction site [polypeptide binding]; other site 1340495003745 25S rRNA binding site [nucleotide binding]; other site 1340495003746 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1340495003747 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1340495003748 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 1340495003749 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1340495003750 Competence protein; Region: Competence; pfam03772 1340495003751 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1340495003752 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1340495003753 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1340495003754 catalytic motif [active] 1340495003755 Zn binding site [ion binding]; other site 1340495003756 SLBB domain; Region: SLBB; pfam10531 1340495003757 comEA protein; Region: comE; TIGR01259 1340495003758 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1340495003759 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1340495003760 protein binding site [polypeptide binding]; other site 1340495003761 PDZ domain; Region: PDZ_2; pfam13180 1340495003762 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1340495003763 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1340495003764 active site 1340495003765 (T/H)XGH motif; other site 1340495003766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340495003767 S-adenosylmethionine binding site [chemical binding]; other site 1340495003768 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 1340495003769 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1340495003770 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1340495003771 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1340495003772 G1 box; other site 1340495003773 putative GEF interaction site [polypeptide binding]; other site 1340495003774 GTP/Mg2+ binding site [chemical binding]; other site 1340495003775 Switch I region; other site 1340495003776 G2 box; other site 1340495003777 G3 box; other site 1340495003778 Switch II region; other site 1340495003779 G4 box; other site 1340495003780 G5 box; other site 1340495003781 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1340495003782 Elongation Factor G, domain II; Region: EFG_II; pfam14492 1340495003783 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1340495003784 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1340495003785 active site 1340495003786 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1340495003787 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1340495003788 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1340495003789 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1340495003790 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 1340495003791 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1340495003792 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1340495003793 E3 interaction surface; other site 1340495003794 lipoyl attachment site [posttranslational modification]; other site 1340495003795 e3 binding domain; Region: E3_binding; pfam02817 1340495003796 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1340495003797 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1340495003798 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1340495003799 alpha subunit interface [polypeptide binding]; other site 1340495003800 TPP binding site [chemical binding]; other site 1340495003801 heterodimer interface [polypeptide binding]; other site 1340495003802 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1340495003803 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1340495003804 TPP-binding site [chemical binding]; other site 1340495003805 heterodimer interface [polypeptide binding]; other site 1340495003806 tetramer interface [polypeptide binding]; other site 1340495003807 phosphorylation loop region [posttranslational modification] 1340495003808 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1340495003809 active site 1340495003810 catalytic residues [active] 1340495003811 metal binding site [ion binding]; metal-binding site 1340495003812 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 1340495003813 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1340495003814 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1340495003815 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 1340495003816 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1340495003817 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1340495003818 Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462 1340495003819 NlpC/P60 family; Region: NLPC_P60; pfam00877 1340495003820 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1340495003821 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1340495003822 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1340495003823 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1340495003824 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1340495003825 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1340495003826 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1340495003827 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 1340495003828 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 1340495003829 aminotransferase A; Validated; Region: PRK07683 1340495003830 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1340495003831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1340495003832 homodimer interface [polypeptide binding]; other site 1340495003833 catalytic residue [active] 1340495003834 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1340495003835 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1340495003836 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1340495003837 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1340495003838 dimer interface [polypeptide binding]; other site 1340495003839 active site 1340495003840 catalytic residue [active] 1340495003841 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1340495003842 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1340495003843 metal binding site [ion binding]; metal-binding site 1340495003844 putative dimer interface [polypeptide binding]; other site 1340495003845 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1340495003846 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1340495003847 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1340495003848 trimer interface [polypeptide binding]; other site 1340495003849 active site 1340495003850 substrate binding site [chemical binding]; other site 1340495003851 CoA binding site [chemical binding]; other site 1340495003852 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1340495003853 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1340495003854 active site 1340495003855 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1340495003856 substrate binding site [chemical binding]; other site 1340495003857 catalytic residues [active] 1340495003858 dimer interface [polypeptide binding]; other site 1340495003859 aspartate kinase; Reviewed; Region: PRK09034 1340495003860 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1340495003861 putative catalytic residues [active] 1340495003862 putative nucleotide binding site [chemical binding]; other site 1340495003863 putative aspartate binding site [chemical binding]; other site 1340495003864 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1340495003865 allosteric regulatory residue; other site 1340495003866 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1340495003867 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1340495003868 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 1340495003869 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 1340495003870 Mid-1-related chloride channel (MCLC); Region: MCLC; pfam05934 1340495003871 putative transposase OrfB; Reviewed; Region: PHA02517 1340495003872 HTH-like domain; Region: HTH_21; pfam13276 1340495003873 Integrase core domain; Region: rve; pfam00665 1340495003874 Integrase core domain; Region: rve_3; cl15866 1340495003875 Helix-turn-helix domain; Region: HTH_28; pfam13518 1340495003876 Transposase; Region: HTH_Tnp_1; cl17663 1340495003877 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1340495003878 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1340495003879 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1340495003880 active site 1340495003881 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1340495003882 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 1340495003883 AAA domain; Region: AAA_30; pfam13604 1340495003884 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 1340495003885 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1340495003886 TPR motif; other site 1340495003887 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1340495003888 binding surface 1340495003889 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1340495003890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1340495003891 binding surface 1340495003892 TPR motif; other site 1340495003893 TPR repeat; Region: TPR_11; pfam13414 1340495003894 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1340495003895 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1340495003896 catalytic core [active] 1340495003897 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1340495003898 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1340495003899 Ligand Binding Site [chemical binding]; other site 1340495003900 Putative amino acid metabolizm; Region: DUF1831; pfam08866 1340495003901 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1340495003902 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1340495003903 catalytic residue [active] 1340495003904 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1340495003905 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1340495003906 dimer interface [polypeptide binding]; other site 1340495003907 ADP-ribose binding site [chemical binding]; other site 1340495003908 active site 1340495003909 nudix motif; other site 1340495003910 metal binding site [ion binding]; metal-binding site 1340495003911 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1340495003912 DNA-binding site [nucleotide binding]; DNA binding site 1340495003913 RNA-binding motif; other site 1340495003914 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1340495003915 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1340495003916 active site 1340495003917 HIGH motif; other site 1340495003918 KMSKS motif; other site 1340495003919 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1340495003920 tRNA binding surface [nucleotide binding]; other site 1340495003921 anticodon binding site; other site 1340495003922 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1340495003923 DivIVA protein; Region: DivIVA; pfam05103 1340495003924 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1340495003925 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1340495003926 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1340495003927 RNA binding surface [nucleotide binding]; other site 1340495003928 YGGT family; Region: YGGT; pfam02325 1340495003929 Protein of unknown function (DUF552); Region: DUF552; cl00775 1340495003930 cell division protein FtsZ; Validated; Region: PRK09330 1340495003931 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1340495003932 nucleotide binding site [chemical binding]; other site 1340495003933 SulA interaction site; other site 1340495003934 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1340495003935 Cell division protein FtsA; Region: FtsA; smart00842 1340495003936 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1340495003937 nucleotide binding site [chemical binding]; other site 1340495003938 Cell division protein FtsA; Region: FtsA; pfam14450 1340495003939 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 1340495003940 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1340495003941 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1340495003942 Cell division protein FtsQ; Region: FtsQ; pfam03799 1340495003943 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1340495003944 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1340495003945 active site 1340495003946 homodimer interface [polypeptide binding]; other site 1340495003947 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1340495003948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340495003949 S-adenosylmethionine binding site [chemical binding]; other site 1340495003950 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1340495003951 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1340495003952 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1340495003953 Mg++ binding site [ion binding]; other site 1340495003954 putative catalytic motif [active] 1340495003955 putative substrate binding site [chemical binding]; other site 1340495003956 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1340495003957 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 1340495003958 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1340495003959 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1340495003960 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1340495003961 Cell division protein FtsL; Region: FtsL; cl11433 1340495003962 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1340495003963 cell division protein MraZ; Reviewed; Region: PRK00326 1340495003964 MraZ protein; Region: MraZ; pfam02381 1340495003965 MraZ protein; Region: MraZ; pfam02381 1340495003966 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 1340495003967 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1340495003968 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1340495003969 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1340495003970 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1340495003971 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1340495003972 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1340495003973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340495003974 S-adenosylmethionine binding site [chemical binding]; other site 1340495003975 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1340495003976 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1340495003977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1340495003978 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 1340495003979 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1340495003980 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1340495003981 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1340495003982 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1340495003983 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1340495003984 active site 1340495003985 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1340495003986 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1340495003987 synthetase active site [active] 1340495003988 NTP binding site [chemical binding]; other site 1340495003989 metal binding site [ion binding]; metal-binding site 1340495003990 Thioredoxin; Region: Thioredoxin_5; pfam13743 1340495003991 Peptidase family C69; Region: Peptidase_C69; pfam03577 1340495003992 Competence protein CoiA-like family; Region: CoiA; cl11541 1340495003993 adaptor protein; Provisional; Region: PRK02315 1340495003994 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1340495003995 putative catalytic residues [active] 1340495003996 thiol/disulfide switch; other site 1340495003997 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1340495003998 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 1340495003999 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1340495004000 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1340495004001 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495004002 Integrase core domain; Region: rve; pfam00665 1340495004003 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1340495004004 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 1340495004005 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1340495004006 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1340495004007 active site 1340495004008 motif I; other site 1340495004009 motif II; other site 1340495004010 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1340495004011 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 1340495004012 putative active site [active] 1340495004013 putative metal binding site [ion binding]; other site 1340495004014 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1340495004015 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1340495004016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340495004017 S-adenosylmethionine binding site [chemical binding]; other site 1340495004018 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1340495004019 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1340495004020 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1340495004021 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1340495004022 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1340495004023 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1340495004024 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1340495004025 Walker A motif; other site 1340495004026 ATP binding site [chemical binding]; other site 1340495004027 Walker B motif; other site 1340495004028 hypothetical protein; Validated; Region: PRK00110 1340495004029 catabolite control protein A; Region: ccpA; TIGR01481 1340495004030 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1340495004031 DNA binding site [nucleotide binding] 1340495004032 domain linker motif; other site 1340495004033 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1340495004034 dimerization interface [polypeptide binding]; other site 1340495004035 effector binding site; other site 1340495004036 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1340495004037 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1340495004038 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1340495004039 active site 1340495004040 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1340495004041 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1340495004042 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1340495004043 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1340495004044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1340495004045 active site 1340495004046 motif I; other site 1340495004047 motif II; other site 1340495004048 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1340495004049 FOG: CBS domain [General function prediction only]; Region: COG0517 1340495004050 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1340495004051 active site 1340495004052 metal binding site [ion binding]; metal-binding site 1340495004053 homotetramer interface [polypeptide binding]; other site 1340495004054 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1340495004055 active site 1340495004056 dimerization interface [polypeptide binding]; other site 1340495004057 glutamate racemase; Provisional; Region: PRK00865 1340495004058 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1340495004059 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1340495004060 catalytic residues [active] 1340495004061 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1340495004062 MutS domain III; Region: MutS_III; pfam05192 1340495004063 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1340495004064 Walker A/P-loop; other site 1340495004065 ATP binding site [chemical binding]; other site 1340495004066 Q-loop/lid; other site 1340495004067 ABC transporter signature motif; other site 1340495004068 Walker B; other site 1340495004069 D-loop; other site 1340495004070 H-loop/switch region; other site 1340495004071 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1340495004072 Smr domain; Region: Smr; pfam01713 1340495004073 Colicin V production protein; Region: Colicin_V; pfam02674 1340495004074 hypothetical protein; Provisional; Region: PRK13678 1340495004075 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1340495004076 hypothetical protein; Provisional; Region: PRK05473 1340495004077 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1340495004078 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1340495004079 motif 1; other site 1340495004080 active site 1340495004081 motif 2; other site 1340495004082 motif 3; other site 1340495004083 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1340495004084 DHHA1 domain; Region: DHHA1; pfam02272 1340495004085 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1340495004086 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1340495004087 ATP binding site [chemical binding]; other site 1340495004088 Mg++ binding site [ion binding]; other site 1340495004089 motif III; other site 1340495004090 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1340495004091 nucleotide binding region [chemical binding]; other site 1340495004092 ATP-binding site [chemical binding]; other site 1340495004093 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1340495004094 DHH family; Region: DHH; pfam01368 1340495004095 DHHA1 domain; Region: DHHA1; pfam02272 1340495004096 Preprotein translocase subunit; Region: YajC; pfam02699 1340495004097 Queuine tRNA-ribosyltransferase; Region: TGT; cl19224 1340495004098 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1340495004099 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1340495004100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495004101 Walker A motif; other site 1340495004102 ATP binding site [chemical binding]; other site 1340495004103 Walker B motif; other site 1340495004104 arginine finger; other site 1340495004105 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1340495004106 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1340495004107 RuvA N terminal domain; Region: RuvA_N; pfam01330 1340495004108 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 1340495004109 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1340495004110 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1340495004111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1340495004112 ATP binding site [chemical binding]; other site 1340495004113 Mg2+ binding site [ion binding]; other site 1340495004114 G-X-G motif; other site 1340495004115 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1340495004116 ATP binding site [chemical binding]; other site 1340495004117 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 1340495004118 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1340495004119 MutS domain I; Region: MutS_I; pfam01624 1340495004120 MutS domain II; Region: MutS_II; pfam05188 1340495004121 MutS domain III; Region: MutS_III; pfam05192 1340495004122 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1340495004123 Walker A/P-loop; other site 1340495004124 ATP binding site [chemical binding]; other site 1340495004125 Q-loop/lid; other site 1340495004126 ABC transporter signature motif; other site 1340495004127 Walker B; other site 1340495004128 D-loop; other site 1340495004129 H-loop/switch region; other site 1340495004130 phosphodiesterase; Provisional; Region: PRK12704 1340495004131 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 1340495004132 KH domain; Region: KH_1; pfam00013 1340495004133 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1340495004134 Zn2+ binding site [ion binding]; other site 1340495004135 Mg2+ binding site [ion binding]; other site 1340495004136 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1340495004137 recombinase A; Provisional; Region: recA; PRK09354 1340495004138 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1340495004139 hexamer interface [polypeptide binding]; other site 1340495004140 Walker A motif; other site 1340495004141 ATP binding site [chemical binding]; other site 1340495004142 Walker B motif; other site 1340495004143 competence damage-inducible protein A; Provisional; Region: PRK00549 1340495004144 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1340495004145 putative MPT binding site; other site 1340495004146 Competence-damaged protein; Region: CinA; pfam02464 1340495004147 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1340495004148 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1340495004149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1340495004150 non-specific DNA binding site [nucleotide binding]; other site 1340495004151 salt bridge; other site 1340495004152 sequence-specific DNA binding site [nucleotide binding]; other site 1340495004153 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1340495004154 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1340495004155 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1340495004156 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1340495004157 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1340495004158 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1340495004159 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1340495004160 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1340495004161 substrate binding pocket [chemical binding]; other site 1340495004162 membrane-bound complex binding site; other site 1340495004163 hinge residues; other site 1340495004164 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1340495004165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340495004166 Walker A/P-loop; other site 1340495004167 ATP binding site [chemical binding]; other site 1340495004168 Q-loop/lid; other site 1340495004169 ABC transporter signature motif; other site 1340495004170 Walker B; other site 1340495004171 D-loop; other site 1340495004172 H-loop/switch region; other site 1340495004173 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 1340495004174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1340495004175 dimer interface [polypeptide binding]; other site 1340495004176 conserved gate region; other site 1340495004177 putative PBP binding loops; other site 1340495004178 ABC-ATPase subunit interface; other site 1340495004179 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1340495004180 rod shape-determining protein MreC; Provisional; Region: PRK13922 1340495004181 rod shape-determining protein MreB; Provisional; Region: PRK13927 1340495004182 MreB and similar proteins; Region: MreB_like; cd10225 1340495004183 nucleotide binding site [chemical binding]; other site 1340495004184 Mg binding site [ion binding]; other site 1340495004185 putative protofilament interaction site [polypeptide binding]; other site 1340495004186 RodZ interaction site [polypeptide binding]; other site 1340495004187 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1340495004188 MPN+ (JAMM) motif; other site 1340495004189 Zinc-binding site [ion binding]; other site 1340495004190 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1340495004191 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1340495004192 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1340495004193 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1340495004194 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1340495004195 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1340495004196 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1340495004197 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1340495004198 Walker A/P-loop; other site 1340495004199 ATP binding site [chemical binding]; other site 1340495004200 Q-loop/lid; other site 1340495004201 ABC transporter signature motif; other site 1340495004202 Walker B; other site 1340495004203 D-loop; other site 1340495004204 H-loop/switch region; other site 1340495004205 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1340495004206 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1340495004207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340495004208 Walker A/P-loop; other site 1340495004209 ATP binding site [chemical binding]; other site 1340495004210 Q-loop/lid; other site 1340495004211 ABC transporter signature motif; other site 1340495004212 Walker B; other site 1340495004213 D-loop; other site 1340495004214 H-loop/switch region; other site 1340495004215 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1340495004216 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1340495004217 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1340495004218 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1340495004219 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1340495004220 active site 1340495004221 HIGH motif; other site 1340495004222 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1340495004223 KMSKS motif; other site 1340495004224 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1340495004225 tRNA binding surface [nucleotide binding]; other site 1340495004226 anticodon binding site; other site 1340495004227 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1340495004228 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1340495004229 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1340495004230 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1340495004231 Ligand Binding Site [chemical binding]; other site 1340495004232 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1340495004233 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1340495004234 catalytic residue [active] 1340495004235 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1340495004236 Protein of unknown function (DUF4527); Region: DUF4527; pfam15030 1340495004237 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1340495004238 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1340495004239 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1340495004240 RNA binding surface [nucleotide binding]; other site 1340495004241 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1340495004242 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1340495004243 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1340495004244 Helix-turn-helix domain; Region: HTH_28; pfam13518 1340495004245 putative transposase OrfB; Reviewed; Region: PHA02517 1340495004246 HTH-like domain; Region: HTH_21; pfam13276 1340495004247 Integrase core domain; Region: rve; pfam00665 1340495004248 Integrase core domain; Region: rve_3; pfam13683 1340495004249 CoA-transferase family III; Region: CoA_transf_3; cl19215 1340495004250 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1340495004251 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1340495004252 PYR/PP interface [polypeptide binding]; other site 1340495004253 dimer interface [polypeptide binding]; other site 1340495004254 TPP binding site [chemical binding]; other site 1340495004255 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1340495004256 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1340495004257 TPP-binding site; other site 1340495004258 dimer interface [polypeptide binding]; other site 1340495004259 hypothetical protein; Validated; Region: PRK02101 1340495004260 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1340495004261 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1340495004262 active site 1340495004263 metal binding site [ion binding]; metal-binding site 1340495004264 Antirestriction protein; Region: Antirestrict; pfam03230 1340495004265 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1340495004266 recombination factor protein RarA; Reviewed; Region: PRK13342 1340495004267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495004268 Walker A motif; other site 1340495004269 ATP binding site [chemical binding]; other site 1340495004270 Walker B motif; other site 1340495004271 arginine finger; other site 1340495004272 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1340495004273 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1340495004274 Ligand Binding Site [chemical binding]; other site 1340495004275 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1340495004276 DNA-binding site [nucleotide binding]; DNA binding site 1340495004277 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1340495004278 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1340495004279 putative dimerization interface [polypeptide binding]; other site 1340495004280 putative ligand binding site [chemical binding]; other site 1340495004281 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1340495004282 active site 1340495004283 catalytic tetrad [active] 1340495004284 maltose O-acetyltransferase; Provisional; Region: PRK10092 1340495004285 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1340495004286 active site 1340495004287 substrate binding site [chemical binding]; other site 1340495004288 trimer interface [polypeptide binding]; other site 1340495004289 CoA binding site [chemical binding]; other site 1340495004290 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1340495004291 trimer interface [polypeptide binding]; other site 1340495004292 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1340495004293 substrate binding site [chemical binding]; other site 1340495004294 Mn binding site [ion binding]; other site 1340495004295 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1340495004296 classical (c) SDRs; Region: SDR_c; cd05233 1340495004297 NAD(P) binding site [chemical binding]; other site 1340495004298 active site 1340495004299 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1340495004300 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1340495004301 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1340495004302 Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543 1340495004303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495004304 putative substrate translocation pore; other site 1340495004305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1340495004306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1340495004307 Helix-turn-helix domain; Region: HTH_28; pfam13518 1340495004308 HTH-like domain; Region: HTH_21; pfam13276 1340495004309 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1340495004310 Integrase core domain; Region: rve; pfam00665 1340495004311 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1340495004312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1340495004313 non-specific DNA binding site [nucleotide binding]; other site 1340495004314 salt bridge; other site 1340495004315 sequence-specific DNA binding site [nucleotide binding]; other site 1340495004316 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1340495004317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1340495004318 binding surface 1340495004319 TPR motif; other site 1340495004320 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1340495004321 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495004322 Integrase core domain; Region: rve; pfam00665 1340495004323 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1340495004324 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1340495004325 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1340495004326 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1340495004327 lipoyl attachment site [posttranslational modification]; other site 1340495004328 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1340495004329 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1340495004330 Haemolytic domain; Region: Haemolytic; cl00506 1340495004331 rod shape-determining protein MreB; Provisional; Region: PRK13930 1340495004332 MreB and similar proteins; Region: MreB_like; cd10225 1340495004333 nucleotide binding site [chemical binding]; other site 1340495004334 Mg binding site [ion binding]; other site 1340495004335 putative protofilament interaction site [polypeptide binding]; other site 1340495004336 RodZ interaction site [polypeptide binding]; other site 1340495004337 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 1340495004338 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1340495004339 hinge; other site 1340495004340 active site 1340495004341 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1340495004342 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1340495004343 gamma subunit interface [polypeptide binding]; other site 1340495004344 epsilon subunit interface [polypeptide binding]; other site 1340495004345 LBP interface [polypeptide binding]; other site 1340495004346 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1340495004347 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1340495004348 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1340495004349 alpha subunit interaction interface [polypeptide binding]; other site 1340495004350 Walker A motif; other site 1340495004351 ATP binding site [chemical binding]; other site 1340495004352 Walker B motif; other site 1340495004353 inhibitor binding site; inhibition site 1340495004354 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1340495004355 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1340495004356 core domain interface [polypeptide binding]; other site 1340495004357 delta subunit interface [polypeptide binding]; other site 1340495004358 epsilon subunit interface [polypeptide binding]; other site 1340495004359 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1340495004360 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1340495004361 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1340495004362 beta subunit interaction interface [polypeptide binding]; other site 1340495004363 Walker A motif; other site 1340495004364 ATP binding site [chemical binding]; other site 1340495004365 Walker B motif; other site 1340495004366 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1340495004367 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1340495004368 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 1340495004369 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1340495004370 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1340495004371 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1340495004372 Sulfate transporter family; Region: Sulfate_transp; cl19250 1340495004373 uracil-xanthine permease; Region: ncs2; TIGR00801 1340495004374 YibE/F-like protein; Region: YibE_F; pfam07907 1340495004375 YibE/F-like protein; Region: YibE_F; pfam07907 1340495004376 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1340495004377 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 1340495004378 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1340495004379 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1340495004380 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1340495004381 active site 1340495004382 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1340495004383 dimer interface [polypeptide binding]; other site 1340495004384 active site 1340495004385 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1340495004386 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1340495004387 folate binding site [chemical binding]; other site 1340495004388 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1340495004389 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1340495004390 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1340495004391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340495004392 S-adenosylmethionine binding site [chemical binding]; other site 1340495004393 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1340495004394 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1340495004395 RF-1 domain; Region: RF-1; pfam00472 1340495004396 thymidine kinase; Provisional; Region: PRK04296 1340495004397 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1340495004398 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1340495004399 Predicted Zn-ribbon RNA-binding protein with a function in translation [Translation, ribosomal structure and biogenesis]; Region: COG2888; cl19729 1340495004400 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1340495004401 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1340495004402 catalytic triad [active] 1340495004403 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1340495004404 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1340495004405 Arginine repressor [Transcription]; Region: ArgR; COG1438 1340495004406 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1340495004407 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1340495004408 arginine deiminase; Provisional; Region: PRK01388 1340495004409 Beta-lactamase; Region: Beta-lactamase; pfam00144 1340495004410 MucBP domain; Region: MucBP; pfam06458 1340495004411 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1340495004412 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1340495004413 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1340495004414 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1340495004415 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1340495004416 motif II; other site 1340495004417 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1340495004418 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1340495004419 Matrixin; Region: Peptidase_M10; pfam00413 1340495004420 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 1340495004421 active site 1340495004422 EamA-like transporter family; Region: EamA; pfam00892 1340495004423 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1340495004424 EamA-like transporter family; Region: EamA; pfam00892 1340495004425 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1340495004426 putative substrate binding site [chemical binding]; other site 1340495004427 nucleotide binding site [chemical binding]; other site 1340495004428 nucleotide binding site [chemical binding]; other site 1340495004429 homodimer interface [polypeptide binding]; other site 1340495004430 ornithine carbamoyltransferase; Provisional; Region: PRK04284 1340495004431 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1340495004432 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1340495004433 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1340495004434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1340495004435 active site 1340495004436 phosphorylation site [posttranslational modification] 1340495004437 intermolecular recognition site; other site 1340495004438 dimerization interface [polypeptide binding]; other site 1340495004439 YcbB domain; Region: YcbB; pfam08664 1340495004440 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1340495004441 N- and C-terminal domain interface [polypeptide binding]; other site 1340495004442 D-xylulose kinase; Region: XylB; TIGR01312 1340495004443 active site 1340495004444 MgATP binding site [chemical binding]; other site 1340495004445 catalytic site [active] 1340495004446 metal binding site [ion binding]; metal-binding site 1340495004447 xylulose binding site [chemical binding]; other site 1340495004448 homodimer interface [polypeptide binding]; other site 1340495004449 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1340495004450 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1340495004451 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1340495004452 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1340495004453 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1340495004454 active site 1340495004455 dimer interface [polypeptide binding]; other site 1340495004456 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1340495004457 dimer interface [polypeptide binding]; other site 1340495004458 active site 1340495004459 maltose O-acetyltransferase; Provisional; Region: PRK10092 1340495004460 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1340495004461 active site 1340495004462 substrate binding site [chemical binding]; other site 1340495004463 trimer interface [polypeptide binding]; other site 1340495004464 CoA binding site [chemical binding]; other site 1340495004465 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1340495004466 Sugar transport protein; Region: Sugar_transport; cl19288 1340495004467 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1340495004468 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1340495004469 dimerization interface [polypeptide binding]; other site 1340495004470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1340495004471 dimer interface [polypeptide binding]; other site 1340495004472 phosphorylation site [posttranslational modification] 1340495004473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1340495004474 ATP binding site [chemical binding]; other site 1340495004475 Mg2+ binding site [ion binding]; other site 1340495004476 G-X-G motif; other site 1340495004477 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1340495004478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1340495004479 active site 1340495004480 phosphorylation site [posttranslational modification] 1340495004481 intermolecular recognition site; other site 1340495004482 dimerization interface [polypeptide binding]; other site 1340495004483 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1340495004484 DNA binding site [nucleotide binding] 1340495004485 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 1340495004486 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1340495004487 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 1340495004488 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1340495004489 Int/Topo IB signature motif; other site 1340495004490 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1340495004491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1340495004492 non-specific DNA binding site [nucleotide binding]; other site 1340495004493 salt bridge; other site 1340495004494 sequence-specific DNA binding site [nucleotide binding]; other site 1340495004495 Helix-turn-helix domain; Region: HTH_17; cl17695 1340495004496 D5 N terminal like; Region: D5_N; pfam08706 1340495004497 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1340495004498 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1340495004499 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1340495004500 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1340495004501 Phage Terminase; Region: Terminase_1; cl19862 1340495004502 Phage portal protein; Region: Phage_portal; pfam04860 1340495004503 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1340495004504 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1340495004505 Phage capsid family; Region: Phage_capsid; pfam05065 1340495004506 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1340495004507 oligomerization interface [polypeptide binding]; other site 1340495004508 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1340495004509 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495004510 Integrase core domain; Region: rve; pfam00665 1340495004511 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1340495004512 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1340495004513 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1340495004514 active site 1340495004515 motif I; other site 1340495004516 motif II; other site 1340495004517 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 1340495004518 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1340495004519 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1340495004520 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1340495004521 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1340495004522 catalytic triad [active] 1340495004523 catalytic triad [active] 1340495004524 oxyanion hole [active] 1340495004525 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495004526 Integrase core domain; Region: rve; pfam00665 1340495004527 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1340495004528 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1340495004529 glutaminase active site [active] 1340495004530 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1340495004531 dimer interface [polypeptide binding]; other site 1340495004532 active site 1340495004533 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1340495004534 dimer interface [polypeptide binding]; other site 1340495004535 active site 1340495004536 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1340495004537 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1340495004538 active site 1340495004539 substrate binding site [chemical binding]; other site 1340495004540 metal binding site [ion binding]; metal-binding site 1340495004541 YbbR-like protein; Region: YbbR; pfam07949 1340495004542 YbbR-like protein; Region: YbbR; pfam07949 1340495004543 TIGR00159 family protein; Region: TIGR00159 1340495004544 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1340495004545 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1340495004546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495004547 putative substrate translocation pore; other site 1340495004548 D-ribose pyranase; Provisional; Region: PRK11797 1340495004549 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1340495004550 substrate binding site [chemical binding]; other site 1340495004551 dimer interface [polypeptide binding]; other site 1340495004552 ATP binding site [chemical binding]; other site 1340495004553 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1340495004554 FAD binding domain; Region: FAD_binding_4; pfam01565 1340495004555 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1340495004556 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1340495004557 active site 1340495004558 catalytic site [active] 1340495004559 substrate binding site [chemical binding]; other site 1340495004560 PAS domain; Region: PAS_10; pfam13596 1340495004561 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1340495004562 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1340495004563 Coenzyme A binding pocket [chemical binding]; other site 1340495004564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1340495004565 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1340495004566 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1340495004567 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1340495004568 ligand binding site [chemical binding]; other site 1340495004569 active site 1340495004570 UGI interface [polypeptide binding]; other site 1340495004571 catalytic site [active] 1340495004572 Tubby C 2; Region: Tub_2; cl02043 1340495004573 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1340495004574 SmpB-tmRNA interface; other site 1340495004575 ribonuclease R; Region: RNase_R; TIGR02063 1340495004576 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1340495004577 RNB domain; Region: RNB; pfam00773 1340495004578 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1340495004579 RNA binding site [nucleotide binding]; other site 1340495004580 Esterase/lipase [General function prediction only]; Region: COG1647 1340495004581 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 1340495004582 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1340495004583 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1340495004584 Cl- selectivity filter; other site 1340495004585 Cl- binding residues [ion binding]; other site 1340495004586 pore gating glutamate residue; other site 1340495004587 dimer interface [polypeptide binding]; other site 1340495004588 H+/Cl- coupling transport residue; other site 1340495004589 TrkA-C domain; Region: TrkA_C; pfam02080 1340495004590 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1340495004591 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1340495004592 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1340495004593 enolase; Provisional; Region: eno; PRK00077 1340495004594 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1340495004595 dimer interface [polypeptide binding]; other site 1340495004596 metal binding site [ion binding]; metal-binding site 1340495004597 substrate binding pocket [chemical binding]; other site 1340495004598 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1340495004599 substrate binding site [chemical binding]; other site 1340495004600 dimer interface [polypeptide binding]; other site 1340495004601 catalytic triad [active] 1340495004602 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1340495004603 substrate binding site [chemical binding]; other site 1340495004604 hinge regions; other site 1340495004605 ADP binding site [chemical binding]; other site 1340495004606 catalytic site [active] 1340495004607 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1340495004608 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1340495004609 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1340495004610 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1340495004611 oligomer interface [polypeptide binding]; other site 1340495004612 active site residues [active] 1340495004613 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1340495004614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495004615 putative substrate translocation pore; other site 1340495004616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1340495004617 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 1340495004618 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 1340495004619 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 1340495004620 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1340495004621 phosphate binding site [ion binding]; other site 1340495004622 putative substrate binding pocket [chemical binding]; other site 1340495004623 dimer interface [polypeptide binding]; other site 1340495004624 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1340495004625 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1340495004626 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1340495004627 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1340495004628 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1340495004629 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1340495004630 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1340495004631 excinuclease ABC subunit B; Provisional; Region: PRK05298 1340495004632 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1340495004633 ATP binding site [chemical binding]; other site 1340495004634 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1340495004635 nucleotide binding region [chemical binding]; other site 1340495004636 ATP-binding site [chemical binding]; other site 1340495004637 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1340495004638 UvrB/uvrC motif; Region: UVR; pfam02151 1340495004639 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1340495004640 Zn2+ binding site [ion binding]; other site 1340495004641 Mg2+ binding site [ion binding]; other site 1340495004642 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1340495004643 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1340495004644 active site 1340495004645 substrate binding site [chemical binding]; other site 1340495004646 metal binding site [ion binding]; metal-binding site 1340495004647 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1340495004648 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1340495004649 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1340495004650 substrate binding pocket [chemical binding]; other site 1340495004651 membrane-bound complex binding site; other site 1340495004652 hinge residues; other site 1340495004653 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1340495004654 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1340495004655 metal binding site [ion binding]; metal-binding site 1340495004656 dimer interface [polypeptide binding]; other site 1340495004657 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1340495004658 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1340495004659 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1340495004660 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1340495004661 Cysteine-rich domain; Region: CCG; pfam02754 1340495004662 Cysteine-rich domain; Region: CCG; pfam02754 1340495004663 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1340495004664 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1340495004665 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1340495004666 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1340495004667 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1340495004668 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1340495004669 active site 1340495004670 tetramer interface; other site 1340495004671 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1340495004672 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1340495004673 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1340495004674 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1340495004675 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1340495004676 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1340495004677 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1340495004678 Hpr binding site; other site 1340495004679 active site 1340495004680 homohexamer subunit interaction site [polypeptide binding]; other site 1340495004681 Membrane protein of unknown function; Region: DUF360; pfam04020 1340495004682 PspC domain; Region: PspC; pfam04024 1340495004683 peptide chain release factor 2; Provisional; Region: PRK05589 1340495004684 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1340495004685 RF-1 domain; Region: RF-1; pfam00472 1340495004686 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 1340495004687 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1340495004688 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1340495004689 nucleotide binding region [chemical binding]; other site 1340495004690 ATP-binding site [chemical binding]; other site 1340495004691 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 1340495004692 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1340495004693 30S subunit binding site; other site 1340495004694 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1340495004695 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1340495004696 active site 1340495004697 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1340495004698 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1340495004699 ATP binding site [chemical binding]; other site 1340495004700 putative Mg++ binding site [ion binding]; other site 1340495004701 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1340495004702 nucleotide binding region [chemical binding]; other site 1340495004703 ATP-binding site [chemical binding]; other site 1340495004704 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1340495004705 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1340495004706 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1340495004707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495004708 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1340495004709 putative substrate translocation pore; other site 1340495004710 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1340495004711 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1340495004712 Amino acid permease; Region: AA_permease_2; pfam13520 1340495004713 K+ potassium transporter; Region: K_trans; cl15781 1340495004714 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1340495004715 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1340495004716 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1340495004717 putative deacylase active site [active] 1340495004718 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 1340495004719 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1340495004720 ring oligomerisation interface [polypeptide binding]; other site 1340495004721 ATP/Mg binding site [chemical binding]; other site 1340495004722 stacking interactions; other site 1340495004723 hinge regions; other site 1340495004724 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1340495004725 oligomerisation interface [polypeptide binding]; other site 1340495004726 mobile loop; other site 1340495004727 roof hairpin; other site 1340495004728 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1340495004729 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1340495004730 CoA binding domain; Region: CoA_binding; pfam02629 1340495004731 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1340495004732 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1340495004733 ABC transporter; Region: ABC_tran_2; pfam12848 1340495004734 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1340495004735 Plasminogen-binding protein pgbA C-terminal; Region: PGBA_C; pfam15437 1340495004736 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 1340495004737 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1340495004738 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1340495004739 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 1340495004740 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1340495004741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1340495004742 homodimer interface [polypeptide binding]; other site 1340495004743 catalytic residue [active] 1340495004744 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1340495004745 putative active site [active] 1340495004746 catalytic triad [active] 1340495004747 putative dimer interface [polypeptide binding]; other site 1340495004748 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1340495004749 nucleotide binding site [chemical binding]; other site 1340495004750 homotetrameric interface [polypeptide binding]; other site 1340495004751 putative phosphate binding site [ion binding]; other site 1340495004752 putative allosteric binding site; other site 1340495004753 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1340495004754 putative catalytic cysteine [active] 1340495004755 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1340495004756 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1340495004757 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 1340495004758 UGMP family protein; Validated; Region: PRK09604 1340495004759 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1340495004760 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1340495004761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1340495004762 Coenzyme A binding pocket [chemical binding]; other site 1340495004763 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1340495004764 Glycoprotease family; Region: Peptidase_M22; pfam00814 1340495004765 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1340495004766 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1340495004767 NAD binding site [chemical binding]; other site 1340495004768 homodimer interface [polypeptide binding]; other site 1340495004769 active site 1340495004770 substrate binding site [chemical binding]; other site 1340495004771 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1340495004772 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 1340495004773 polyphosphate kinase; Provisional; Region: PRK05443 1340495004774 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1340495004775 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1340495004776 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1340495004777 putative domain interface [polypeptide binding]; other site 1340495004778 putative active site [active] 1340495004779 catalytic site [active] 1340495004780 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1340495004781 putative domain interface [polypeptide binding]; other site 1340495004782 putative active site [active] 1340495004783 catalytic site [active] 1340495004784 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1340495004785 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1340495004786 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 1340495004787 active site 1340495004788 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1340495004789 active site 2 [active] 1340495004790 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1340495004791 putative SAM binding site [chemical binding]; other site 1340495004792 putative homodimer interface [polypeptide binding]; other site 1340495004793 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1340495004794 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1340495004795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495004796 Walker A motif; other site 1340495004797 ATP binding site [chemical binding]; other site 1340495004798 Walker B motif; other site 1340495004799 arginine finger; other site 1340495004800 Protein of unknown function (DUF970); Region: DUF970; cl17525 1340495004801 thymidylate kinase; Validated; Region: tmk; PRK00698 1340495004802 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1340495004803 TMP-binding site; other site 1340495004804 ATP-binding site [chemical binding]; other site 1340495004805 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1340495004806 recombination protein RecR; Reviewed; Region: recR; PRK00076 1340495004807 RecR protein; Region: RecR; pfam02132 1340495004808 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1340495004809 putative active site [active] 1340495004810 putative metal-binding site [ion binding]; other site 1340495004811 tetramer interface [polypeptide binding]; other site 1340495004812 hypothetical protein; Validated; Region: PRK00153 1340495004813 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1340495004814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495004815 Walker A motif; other site 1340495004816 ATP binding site [chemical binding]; other site 1340495004817 Walker B motif; other site 1340495004818 arginine finger; other site 1340495004819 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1340495004820 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1340495004821 nucleoside/Zn binding site; other site 1340495004822 dimer interface [polypeptide binding]; other site 1340495004823 catalytic motif [active] 1340495004824 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1340495004825 catalytic residues [active] 1340495004826 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 1340495004827 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1340495004828 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1340495004829 active site 1340495004830 dimer interface [polypeptide binding]; other site 1340495004831 catalytic residues [active] 1340495004832 effector binding site; other site 1340495004833 R2 peptide binding site; other site 1340495004834 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1340495004835 dimer interface [polypeptide binding]; other site 1340495004836 putative radical transfer pathway; other site 1340495004837 diiron center [ion binding]; other site 1340495004838 tyrosyl radical; other site 1340495004839 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1340495004840 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1340495004841 putative catalytic cysteine [active] 1340495004842 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1340495004843 putative active site [active] 1340495004844 metal binding site [ion binding]; metal-binding site 1340495004845 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1340495004846 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1340495004847 Predicted membrane protein [Function unknown]; Region: COG4709 1340495004848 Predicted transcriptional regulators [Transcription]; Region: COG1695 1340495004849 dimerization interface [polypeptide binding]; other site 1340495004850 putative DNA binding site [nucleotide binding]; other site 1340495004851 putative Zn2+ binding site [ion binding]; other site 1340495004852 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1340495004853 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1340495004854 peripheral dimer interface [polypeptide binding]; other site 1340495004855 core dimer interface [polypeptide binding]; other site 1340495004856 L10 interface [polypeptide binding]; other site 1340495004857 L11 interface [polypeptide binding]; other site 1340495004858 putative EF-Tu interaction site [polypeptide binding]; other site 1340495004859 putative EF-G interaction site [polypeptide binding]; other site 1340495004860 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1340495004861 23S rRNA interface [nucleotide binding]; other site 1340495004862 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1340495004863 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1340495004864 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1340495004865 active site 1340495004866 homodimer interface [polypeptide binding]; other site 1340495004867 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1340495004868 N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; Region: GlcNAc-1-P_transferase; cd06436 1340495004869 DXD motif; other site 1340495004870 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1340495004871 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1340495004872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1340495004873 homodimer interface [polypeptide binding]; other site 1340495004874 catalytic residue [active] 1340495004875 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1340495004876 mRNA/rRNA interface [nucleotide binding]; other site 1340495004877 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1340495004878 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1340495004879 23S rRNA interface [nucleotide binding]; other site 1340495004880 L7/L12 interface [polypeptide binding]; other site 1340495004881 putative thiostrepton binding site; other site 1340495004882 L25 interface [polypeptide binding]; other site 1340495004883 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1340495004884 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1340495004885 putative homodimer interface [polypeptide binding]; other site 1340495004886 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1340495004887 heterodimer interface [polypeptide binding]; other site 1340495004888 homodimer interface [polypeptide binding]; other site 1340495004889 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1340495004890 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1340495004891 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1340495004892 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1340495004893 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1340495004894 active site 1340495004895 metal binding site [ion binding]; metal-binding site 1340495004896 dimerization interface [polypeptide binding]; other site 1340495004897 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1340495004898 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1340495004899 active site 1340495004900 HIGH motif; other site 1340495004901 KMSKS motif; other site 1340495004902 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1340495004903 tRNA binding surface [nucleotide binding]; other site 1340495004904 anticodon binding site; other site 1340495004905 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1340495004906 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 1340495004907 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1340495004908 putative active site [active] 1340495004909 DNA repair protein RadA; Provisional; Region: PRK11823 1340495004910 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1340495004911 Walker A motif/ATP binding site; other site 1340495004912 ATP binding site [chemical binding]; other site 1340495004913 Walker B motif; other site 1340495004914 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1340495004915 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1340495004916 trimer interface [polypeptide binding]; other site 1340495004917 active site 1340495004918 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1340495004919 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1340495004920 Coenzyme A binding pocket [chemical binding]; other site 1340495004921 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1340495004922 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1340495004923 active site 1340495004924 dimer interface [polypeptide binding]; other site 1340495004925 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1340495004926 trimer interface [polypeptide binding]; other site 1340495004927 active site 1340495004928 G bulge; other site 1340495004929 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1340495004930 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1340495004931 substrate binding pocket [chemical binding]; other site 1340495004932 membrane-bound complex binding site; other site 1340495004933 hinge residues; other site 1340495004934 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1340495004935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340495004936 Walker A/P-loop; other site 1340495004937 ATP binding site [chemical binding]; other site 1340495004938 Q-loop/lid; other site 1340495004939 ABC transporter signature motif; other site 1340495004940 Walker B; other site 1340495004941 D-loop; other site 1340495004942 H-loop/switch region; other site 1340495004943 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 1340495004944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1340495004945 dimer interface [polypeptide binding]; other site 1340495004946 conserved gate region; other site 1340495004947 putative PBP binding loops; other site 1340495004948 ABC-ATPase subunit interface; other site 1340495004949 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1340495004950 homodimer interface [polypeptide binding]; other site 1340495004951 substrate-cofactor binding pocket; other site 1340495004952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1340495004953 catalytic residue [active] 1340495004954 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1340495004955 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 1340495004956 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1340495004957 catalytic core [active] 1340495004958 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 1340495004959 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1340495004960 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1340495004961 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1340495004962 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1340495004963 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1340495004964 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1340495004965 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1340495004966 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 1340495004967 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1340495004968 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1340495004969 RNA binding site [nucleotide binding]; other site 1340495004970 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1340495004971 homodimer interface [polypeptide binding]; other site 1340495004972 NAD binding pocket [chemical binding]; other site 1340495004973 ATP binding pocket [chemical binding]; other site 1340495004974 Mg binding site [ion binding]; other site 1340495004975 active-site loop [active] 1340495004976 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1340495004977 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1340495004978 active site 1340495004979 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1340495004980 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1340495004981 DNA-binding site [nucleotide binding]; DNA binding site 1340495004982 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1340495004983 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1340495004984 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 1340495004985 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1340495004986 TrkA-C domain; Region: TrkA_C; pfam02080 1340495004987 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1340495004988 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1340495004989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495004990 putative substrate translocation pore; other site 1340495004991 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1340495004992 putative phosphoesterase; Region: acc_ester; TIGR03729 1340495004993 POT family; Region: PTR2; cl17359 1340495004994 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1340495004995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495004996 putative substrate translocation pore; other site 1340495004997 Bacterial lipoprotein; Region: DUF3642; pfam12182 1340495004998 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1340495004999 phosphate binding site [ion binding]; other site 1340495005000 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1340495005001 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1340495005002 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1340495005003 Predicted transcriptional regulators [Transcription]; Region: COG1733 1340495005004 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1340495005005 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1340495005006 dimer interface [polypeptide binding]; other site 1340495005007 catalytic triad [active] 1340495005008 peroxidatic and resolving cysteines [active] 1340495005009 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 1340495005010 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1340495005011 Arylsulfotransferase (ASST); Region: Arylsulfotrans; cl19972 1340495005012 transposase/IS protein; Provisional; Region: PRK09183 1340495005013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495005014 Walker A motif; other site 1340495005015 ATP binding site [chemical binding]; other site 1340495005016 Walker B motif; other site 1340495005017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1340495005018 Integrase core domain; Region: rve; pfam00665 1340495005019 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1340495005020 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1340495005021 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1340495005022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1340495005023 Transposase, Mutator family; Region: Transposase_mut; cl19537 1340495005024 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1340495005025 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1340495005026 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1340495005027 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1340495005028 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1340495005029 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495005030 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495005031 Integrase core domain; Region: rve; pfam00665 1340495005032 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1340495005033 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1340495005034 dimer interface [polypeptide binding]; other site 1340495005035 putative anticodon binding site; other site 1340495005036 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1340495005037 motif 1; other site 1340495005038 active site 1340495005039 motif 2; other site 1340495005040 motif 3; other site 1340495005041 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1340495005042 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1340495005043 FMN binding site [chemical binding]; other site 1340495005044 active site 1340495005045 catalytic residues [active] 1340495005046 substrate binding site [chemical binding]; other site 1340495005047 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1340495005048 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1340495005049 dimerization interface [polypeptide binding]; other site 1340495005050 domain crossover interface; other site 1340495005051 redox-dependent activation switch; other site 1340495005052 FtsH Extracellular; Region: FtsH_ext; pfam06480 1340495005053 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1340495005054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340495005055 Walker A motif; other site 1340495005056 ATP binding site [chemical binding]; other site 1340495005057 Walker B motif; other site 1340495005058 arginine finger; other site 1340495005059 Peptidase family M41; Region: Peptidase_M41; pfam01434 1340495005060 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1340495005061 active site 1340495005062 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1340495005063 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1340495005064 Ligand Binding Site [chemical binding]; other site 1340495005065 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1340495005066 hypothetical protein; Provisional; Region: PRK08582 1340495005067 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1340495005068 RNA binding site [nucleotide binding]; other site 1340495005069 Septum formation initiator; Region: DivIC; cl17659 1340495005070 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1340495005071 RNA binding surface [nucleotide binding]; other site 1340495005072 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1340495005073 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1340495005074 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1340495005075 ATP binding site [chemical binding]; other site 1340495005076 putative Mg++ binding site [ion binding]; other site 1340495005077 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1340495005078 nucleotide binding region [chemical binding]; other site 1340495005079 ATP-binding site [chemical binding]; other site 1340495005080 TRCF domain; Region: TRCF; pfam03461 1340495005081 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1340495005082 putative active site [active] 1340495005083 catalytic residue [active] 1340495005084 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1340495005085 FOG: CBS domain [General function prediction only]; Region: COG0517 1340495005086 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1340495005087 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1340495005088 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 1340495005089 active site 1340495005090 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1340495005091 Na binding site [ion binding]; other site 1340495005092 PemK-like protein; Region: PemK; pfam02452 1340495005093 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1340495005094 alanine racemase; Reviewed; Region: alr; PRK00053 1340495005095 active site 1340495005096 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1340495005097 dimer interface [polypeptide binding]; other site 1340495005098 substrate binding site [chemical binding]; other site 1340495005099 catalytic residues [active] 1340495005100 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1340495005101 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1340495005102 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1340495005103 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1340495005104 acyl-activating enzyme (AAE) consensus motif; other site 1340495005105 AMP binding site [chemical binding]; other site 1340495005106 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1340495005107 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1340495005108 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1340495005109 DltD N-terminal region; Region: DltD_N; pfam04915 1340495005110 DltD central region; Region: DltD_M; pfam04918 1340495005111 DltD C-terminal region; Region: DltD_C; pfam04914 1340495005112 Glutaminase; Region: Glutaminase; cl00907 1340495005113 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1340495005114 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1340495005115 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1340495005116 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1340495005117 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1340495005118 putative transposase OrfB; Reviewed; Region: PHA02517 1340495005119 HTH-like domain; Region: HTH_21; pfam13276 1340495005120 Integrase core domain; Region: rve; pfam00665 1340495005121 Integrase core domain; Region: rve_3; pfam13683 1340495005122 helicase 45; Provisional; Region: PTZ00424 1340495005123 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1340495005124 ATP binding site [chemical binding]; other site 1340495005125 Mg++ binding site [ion binding]; other site 1340495005126 motif III; other site 1340495005127 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1340495005128 nucleotide binding region [chemical binding]; other site 1340495005129 ATP-binding site [chemical binding]; other site 1340495005130 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1340495005131 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1340495005132 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1340495005133 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1340495005134 heat shock protein HtpX; Provisional; Region: PRK04897 1340495005135 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1340495005136 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1340495005137 active site 1340495005138 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1340495005139 catalytic core [active] 1340495005140 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1340495005141 intersubunit interface [polypeptide binding]; other site 1340495005142 active site 1340495005143 zinc binding site [ion binding]; other site 1340495005144 Na+ binding site [ion binding]; other site 1340495005145 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1340495005146 substrate binding site [chemical binding]; other site 1340495005147 dimer interface [polypeptide binding]; other site 1340495005148 catalytic triad [active] 1340495005149 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1340495005150 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; cl17700 1340495005151 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1340495005152 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1340495005153 active site 1340495005154 catalytic site [active] 1340495005155 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1340495005156 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1340495005157 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1340495005158 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 1340495005159 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1340495005160 hinge; other site 1340495005161 active site 1340495005162 CTP synthetase; Validated; Region: pyrG; PRK05380 1340495005163 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1340495005164 Catalytic site [active] 1340495005165 active site 1340495005166 UTP binding site [chemical binding]; other site 1340495005167 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1340495005168 active site 1340495005169 putative oxyanion hole; other site 1340495005170 catalytic triad [active] 1340495005171 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 1340495005172 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1340495005173 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1340495005174 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1340495005175 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1340495005176 Zn2+ binding site [ion binding]; other site 1340495005177 Mg2+ binding site [ion binding]; other site 1340495005178 sugar phosphate phosphatase; Provisional; Region: PRK10513 1340495005179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1340495005180 active site 1340495005181 motif I; other site 1340495005182 motif II; other site 1340495005183 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 1340495005184 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1340495005185 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1340495005186 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1340495005187 active site 1340495005188 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1340495005189 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1340495005190 Substrate binding site; other site 1340495005191 Mg++ binding site; other site 1340495005192 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1340495005193 active site 1340495005194 substrate binding site [chemical binding]; other site 1340495005195 CoA binding site [chemical binding]; other site 1340495005196 pur operon repressor; Provisional; Region: PRK09213 1340495005197 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1340495005198 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1340495005199 active site 1340495005200 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1340495005201 ABC-ATPase subunit interface; other site 1340495005202 dimer interface [polypeptide binding]; other site 1340495005203 putative PBP binding regions; other site 1340495005204 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1340495005205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340495005206 Walker A/P-loop; other site 1340495005207 ATP binding site [chemical binding]; other site 1340495005208 Q-loop/lid; other site 1340495005209 ABC transporter signature motif; other site 1340495005210 Walker B; other site 1340495005211 D-loop; other site 1340495005212 H-loop/switch region; other site 1340495005213 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1340495005214 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1340495005215 intersubunit interface [polypeptide binding]; other site 1340495005216 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1340495005217 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1340495005218 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1340495005219 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1340495005220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340495005221 S-adenosylmethionine binding site [chemical binding]; other site 1340495005222 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1340495005223 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1340495005224 putative active site [active] 1340495005225 putative metal binding site [ion binding]; other site 1340495005226 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1340495005227 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1340495005228 active site 1340495005229 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1340495005230 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1340495005231 active site 1340495005232 HIGH motif; other site 1340495005233 KMSKS motif; other site 1340495005234 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1340495005235 tRNA binding surface [nucleotide binding]; other site 1340495005236 anticodon binding site; other site 1340495005237 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1340495005238 dimer interface [polypeptide binding]; other site 1340495005239 putative tRNA-binding site [nucleotide binding]; other site 1340495005240 Protein of unknown function DUF72; Region: DUF72; pfam01904 1340495005241 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 1340495005242 NAD+ binding site [chemical binding]; other site 1340495005243 substrate binding site [chemical binding]; other site 1340495005244 putative Zn binding site [ion binding]; other site 1340495005245 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1340495005246 homodimer interface [polypeptide binding]; other site 1340495005247 catalytic residues [active] 1340495005248 NAD binding site [chemical binding]; other site 1340495005249 substrate binding pocket [chemical binding]; other site 1340495005250 flexible flap; other site 1340495005251 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1340495005252 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1340495005253 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1340495005254 active site 1340495005255 HIGH motif; other site 1340495005256 dimer interface [polypeptide binding]; other site 1340495005257 KMSKS motif; other site 1340495005258 DNA methylase; Region: N6_N4_Mtase; pfam01555 1340495005259 Nucleoside diphosphate kinase; Region: NDK; pfam00334 1340495005260 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1340495005261 active site 1340495005262 multimer interface [polypeptide binding]; other site 1340495005263 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1340495005264 Part of AAA domain; Region: AAA_19; pfam13245 1340495005265 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 1340495005266 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1340495005267 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1340495005268 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 1340495005269 inhibitor-cofactor binding pocket; inhibition site 1340495005270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1340495005271 catalytic residue [active] 1340495005272 amino acid transporter; Region: 2A0306; TIGR00909 1340495005273 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1340495005274 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1340495005275 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1340495005276 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1340495005277 minor groove reading motif; other site 1340495005278 helix-hairpin-helix signature motif; other site 1340495005279 substrate binding pocket [chemical binding]; other site 1340495005280 active site 1340495005281 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1340495005282 FMN-binding domain; Region: FMN_bind; cl01081 1340495005283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495005284 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1340495005285 putative substrate translocation pore; other site 1340495005286 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495005287 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495005288 Integrase core domain; Region: rve; pfam00665 1340495005289 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 1340495005290 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1340495005291 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1340495005292 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1340495005293 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495005294 Integrase core domain; Region: rve; pfam00665 1340495005295 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1340495005296 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1340495005297 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1340495005298 NAD binding site [chemical binding]; other site 1340495005299 dimer interface [polypeptide binding]; other site 1340495005300 substrate binding site [chemical binding]; other site 1340495005301 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1340495005302 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1340495005303 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340495005304 Walker A/P-loop; other site 1340495005305 ATP binding site [chemical binding]; other site 1340495005306 Q-loop/lid; other site 1340495005307 ABC transporter signature motif; other site 1340495005308 Walker B; other site 1340495005309 D-loop; other site 1340495005310 H-loop/switch region; other site 1340495005311 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1340495005312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1340495005313 dimer interface [polypeptide binding]; other site 1340495005314 conserved gate region; other site 1340495005315 putative PBP binding loops; other site 1340495005316 ABC-ATPase subunit interface; other site 1340495005317 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1340495005318 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1340495005319 metal binding site [ion binding]; metal-binding site 1340495005320 dimer interface [polypeptide binding]; other site 1340495005321 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1340495005322 Cl- selectivity filter; other site 1340495005323 Cl- binding residues [ion binding]; other site 1340495005324 pore gating glutamate residue; other site 1340495005325 dimer interface [polypeptide binding]; other site 1340495005326 H+/Cl- coupling transport residue; other site 1340495005327 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1340495005328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1340495005329 dimer interface [polypeptide binding]; other site 1340495005330 conserved gate region; other site 1340495005331 putative PBP binding loops; other site 1340495005332 ABC-ATPase subunit interface; other site 1340495005333 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1340495005334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340495005335 Walker A/P-loop; other site 1340495005336 ATP binding site [chemical binding]; other site 1340495005337 Q-loop/lid; other site 1340495005338 ABC transporter signature motif; other site 1340495005339 Walker B; other site 1340495005340 D-loop; other site 1340495005341 H-loop/switch region; other site 1340495005342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1340495005343 dimer interface [polypeptide binding]; other site 1340495005344 conserved gate region; other site 1340495005345 putative PBP binding loops; other site 1340495005346 ABC-ATPase subunit interface; other site 1340495005347 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 1340495005348 Predicted transcriptional regulator [Transcription]; Region: COG1959 1340495005349 Rrf2 family protein; Region: rrf2_super; TIGR00738 1340495005350 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1340495005351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1340495005352 NAD(P) binding site [chemical binding]; other site 1340495005353 active site 1340495005354 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 1340495005355 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1340495005356 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1340495005357 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1340495005358 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 1340495005359 active site 1340495005360 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 1340495005361 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495005362 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495005363 Integrase core domain; Region: rve; pfam00665 1340495005364 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1340495005365 TrkA-N domain; Region: TrkA_N; pfam02254 1340495005366 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1340495005367 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 1340495005368 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1340495005369 PLD-like domain; Region: PLDc_2; pfam13091 1340495005370 putative homodimer interface [polypeptide binding]; other site 1340495005371 putative active site [active] 1340495005372 catalytic site [active] 1340495005373 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1340495005374 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1340495005375 ATP binding site [chemical binding]; other site 1340495005376 putative Mg++ binding site [ion binding]; other site 1340495005377 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1340495005378 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1340495005379 nucleotide binding region [chemical binding]; other site 1340495005380 ATP-binding site [chemical binding]; other site 1340495005381 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1340495005382 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1340495005383 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1340495005384 active site 1340495005385 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1340495005386 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 1340495005387 active site 1340495005388 catalytic tetrad [active] 1340495005389 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1340495005390 substrate binding site [chemical binding]; other site 1340495005391 dimer interface [polypeptide binding]; other site 1340495005392 catalytic triad [active] 1340495005393 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1340495005394 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1340495005395 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1340495005396 Cation efflux family; Region: Cation_efflux; cl00316 1340495005397 Cation efflux family; Region: Cation_efflux; cl00316 1340495005398 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1340495005399 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1340495005400 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 1340495005401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1340495005402 NAD(P) binding site [chemical binding]; other site 1340495005403 active site 1340495005404 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1340495005405 classical (c) SDRs; Region: SDR_c; cd05233 1340495005406 NAD(P) binding site [chemical binding]; other site 1340495005407 active site 1340495005408 metabolite-proton symporter; Region: 2A0106; TIGR00883 1340495005409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495005410 putative substrate translocation pore; other site 1340495005411 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1340495005412 active site 1340495005413 Int/Topo IB signature motif; other site 1340495005414 DNA binding site [nucleotide binding] 1340495005415 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495005416 Integrase core domain; Region: rve; pfam00665 1340495005417 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1340495005418 dimer interface [polypeptide binding]; other site 1340495005419 putative active site [active] 1340495005420 trimer interface [polypeptide binding]; other site 1340495005421 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1340495005422 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1340495005423 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1340495005424 FeS/SAM binding site; other site 1340495005425 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1340495005426 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495005427 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495005428 Integrase core domain; Region: rve; pfam00665 1340495005429 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1340495005430 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1340495005431 active site 1340495005432 HIGH motif; other site 1340495005433 dimer interface [polypeptide binding]; other site 1340495005434 KMSKS motif; other site 1340495005435 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1340495005436 RNA binding surface [nucleotide binding]; other site 1340495005437 Protein of unknown function (DUF975); Region: DUF975; cl10504 1340495005438 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1340495005439 catalytic core [active] 1340495005440 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1340495005441 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1340495005442 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1340495005443 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1340495005444 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1340495005445 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1340495005446 purine monophosphate binding site [chemical binding]; other site 1340495005447 dimer interface [polypeptide binding]; other site 1340495005448 putative catalytic residues [active] 1340495005449 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1340495005450 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1340495005451 active site 1340495005452 substrate binding site [chemical binding]; other site 1340495005453 cosubstrate binding site; other site 1340495005454 catalytic site [active] 1340495005455 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1340495005456 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1340495005457 dimerization interface [polypeptide binding]; other site 1340495005458 putative ATP binding site [chemical binding]; other site 1340495005459 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1340495005460 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1340495005461 active site 1340495005462 tetramer interface [polypeptide binding]; other site 1340495005463 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1340495005464 active site 1340495005465 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1340495005466 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1340495005467 dimerization interface [polypeptide binding]; other site 1340495005468 ATP binding site [chemical binding]; other site 1340495005469 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1340495005470 dimerization interface [polypeptide binding]; other site 1340495005471 ATP binding site [chemical binding]; other site 1340495005472 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1340495005473 putative active site [active] 1340495005474 catalytic triad [active] 1340495005475 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1340495005476 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1340495005477 ATP binding site [chemical binding]; other site 1340495005478 active site 1340495005479 substrate binding site [chemical binding]; other site 1340495005480 adenylosuccinate lyase; Provisional; Region: PRK07492 1340495005481 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1340495005482 tetramer interface [polypeptide binding]; other site 1340495005483 active site 1340495005484 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1340495005485 ATP-grasp domain; Region: ATP-grasp; pfam02222 1340495005486 AIR carboxylase; Region: AIRC; pfam00731 1340495005487 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1340495005488 acetolactate synthase; Reviewed; Region: PRK08617 1340495005489 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1340495005490 PYR/PP interface [polypeptide binding]; other site 1340495005491 dimer interface [polypeptide binding]; other site 1340495005492 TPP binding site [chemical binding]; other site 1340495005493 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1340495005494 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1340495005495 TPP-binding site [chemical binding]; other site 1340495005496 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1340495005497 Potassium binding sites [ion binding]; other site 1340495005498 Cesium cation binding sites [ion binding]; other site 1340495005499 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1340495005500 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1340495005501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340495005502 S-adenosylmethionine binding site [chemical binding]; other site 1340495005503 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1340495005504 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1340495005505 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1340495005506 motif II; other site 1340495005507 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1340495005508 active site 1340495005509 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1340495005510 active site 1340495005511 dimer interface [polypeptide binding]; other site 1340495005512 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1340495005513 heterodimer interface [polypeptide binding]; other site 1340495005514 active site 1340495005515 FMN binding site [chemical binding]; other site 1340495005516 homodimer interface [polypeptide binding]; other site 1340495005517 substrate binding site [chemical binding]; other site 1340495005518 dihydroorotase; Validated; Region: pyrC; PRK09357 1340495005519 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1340495005520 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1340495005521 active site 1340495005522 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1340495005523 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1340495005524 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1340495005525 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1340495005526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1340495005527 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1340495005528 dimerization interface [polypeptide binding]; other site 1340495005529 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1340495005530 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1340495005531 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1340495005532 AzlC protein; Region: AzlC; pfam03591 1340495005533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1340495005534 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1340495005535 dimer interface [polypeptide binding]; other site 1340495005536 phosphorylation site [posttranslational modification] 1340495005537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1340495005538 ATP binding site [chemical binding]; other site 1340495005539 Mg2+ binding site [ion binding]; other site 1340495005540 G-X-G motif; other site 1340495005541 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1340495005542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1340495005543 active site 1340495005544 phosphorylation site [posttranslational modification] 1340495005545 intermolecular recognition site; other site 1340495005546 dimerization interface [polypeptide binding]; other site 1340495005547 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1340495005548 DNA binding site [nucleotide binding] 1340495005549 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1340495005550 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1340495005551 active site 1340495005552 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1340495005553 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1340495005554 DNA binding residues [nucleotide binding] 1340495005555 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1340495005556 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1340495005557 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1340495005558 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1340495005559 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1340495005560 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1340495005561 phosphopentomutase; Provisional; Region: PRK05362 1340495005562 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1340495005563 intersubunit interface [polypeptide binding]; other site 1340495005564 active site 1340495005565 catalytic residue [active] 1340495005566 hypothetical protein; Validated; Region: PRK07668 1340495005567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340495005568 GTP-binding protein YchF; Reviewed; Region: PRK09601 1340495005569 YchF GTPase; Region: YchF; cd01900 1340495005570 G1 box; other site 1340495005571 GTP/Mg2+ binding site [chemical binding]; other site 1340495005572 Switch I region; other site 1340495005573 G2 box; other site 1340495005574 Switch II region; other site 1340495005575 G3 box; other site 1340495005576 G4 box; other site 1340495005577 G5 box; other site 1340495005578 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1340495005579 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1340495005580 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1340495005581 ParB-like nuclease domain; Region: ParBc; pfam02195 1340495005582 KorB domain; Region: KorB; pfam08535 1340495005583 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1340495005584 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1340495005585 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1340495005586 P-loop; other site 1340495005587 Magnesium ion binding site [ion binding]; other site 1340495005588 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1340495005589 ParB-like nuclease domain; Region: ParBc; pfam02195 1340495005590 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1340495005591 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1340495005592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340495005593 S-adenosylmethionine binding site [chemical binding]; other site 1340495005594 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 1340495005595 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1340495005596 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1340495005597 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1340495005598 active site 1340495005599 tetramer interface [polypeptide binding]; other site 1340495005600 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1340495005601 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1340495005602 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1340495005603 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1340495005604 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1340495005605 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1340495005606 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1340495005607 Walker A/P-loop; other site 1340495005608 ATP binding site [chemical binding]; other site 1340495005609 Q-loop/lid; other site 1340495005610 ABC transporter signature motif; other site 1340495005611 Walker B; other site 1340495005612 D-loop; other site 1340495005613 H-loop/switch region; other site 1340495005614 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1340495005615 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1340495005616 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1340495005617 substrate binding pocket [chemical binding]; other site 1340495005618 membrane-bound complex binding site; other site 1340495005619 hinge residues; other site 1340495005620 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 1340495005621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1340495005622 dimer interface [polypeptide binding]; other site 1340495005623 conserved gate region; other site 1340495005624 putative PBP binding loops; other site 1340495005625 ABC-ATPase subunit interface; other site 1340495005626 seryl-tRNA synthetase; Provisional; Region: PRK05431 1340495005627 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1340495005628 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1340495005629 dimer interface [polypeptide binding]; other site 1340495005630 active site 1340495005631 motif 1; other site 1340495005632 motif 2; other site 1340495005633 motif 3; other site 1340495005634 putative transposase OrfB; Reviewed; Region: PHA02517 1340495005635 HTH-like domain; Region: HTH_21; pfam13276 1340495005636 Integrase core domain; Region: rve; pfam00665 1340495005637 Integrase core domain; Region: rve_3; cl15866 1340495005638 Helix-turn-helix domain; Region: HTH_28; pfam13518 1340495005639 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1340495005640 Helix-turn-helix domain; Region: HTH_28; pfam13518 1340495005641 Beta-lactamase; Region: Beta-lactamase; pfam00144 1340495005642 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1340495005643 active site 1340495005644 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1340495005645 MgtC family; Region: MgtC; pfam02308 1340495005646 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1340495005647 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1340495005648 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 1340495005649 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1340495005650 AzlC protein; Region: AzlC; cl00570 1340495005651 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1340495005652 DNA-binding site [nucleotide binding]; DNA binding site 1340495005653 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1340495005654 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1340495005655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1340495005656 homodimer interface [polypeptide binding]; other site 1340495005657 catalytic residue [active] 1340495005658 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1340495005659 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1340495005660 active site 1340495005661 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495005662 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495005663 Integrase core domain; Region: rve; pfam00665 1340495005664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1340495005665 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1340495005666 active site 1340495005667 catalytic tetrad [active] 1340495005668 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1340495005669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1340495005670 Coenzyme A binding pocket [chemical binding]; other site 1340495005671 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1340495005672 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1340495005673 Catalytic site [active] 1340495005674 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 1340495005675 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 1340495005676 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1340495005677 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1340495005678 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1340495005679 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1340495005680 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1340495005681 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1340495005682 active site 1340495005683 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1340495005684 dimer interface [polypeptide binding]; other site 1340495005685 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1340495005686 Ligand Binding Site [chemical binding]; other site 1340495005687 Molecular Tunnel; other site 1340495005688 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1340495005689 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1340495005690 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1340495005691 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1340495005692 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1340495005693 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1340495005694 G1 box; other site 1340495005695 GTP/Mg2+ binding site [chemical binding]; other site 1340495005696 Switch I region; other site 1340495005697 G2 box; other site 1340495005698 Switch II region; other site 1340495005699 G3 box; other site 1340495005700 G4 box; other site 1340495005701 G5 box; other site 1340495005702 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1340495005703 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1340495005704 Jag N-terminus; Region: Jag_N; pfam14804 1340495005705 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1340495005706 G-X-X-G motif; other site 1340495005707 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1340495005708 RxxxH motif; other site 1340495005709 OxaA-like protein precursor; Provisional; Region: PRK02463 1340495005710 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1340495005711 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1340495005712 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1340495005713 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1340495005714 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1340495005715 Coenzyme A binding pocket [chemical binding]; other site 1340495005716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1340495005717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1340495005718 HTH-like domain; Region: HTH_21; pfam13276 1340495005719 Integrase core domain; Region: rve; pfam00665 1340495005720 Integrase core domain; Region: rve_3; cl15866 1340495005721 Transposase; Region: HTH_Tnp_1; cl17663 1340495005722 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1340495005723 Transposase; Region: HTH_Tnp_1; cl17663 1340495005724 Helix-turn-helix domain; Region: HTH_28; pfam13518 1340495005725 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1340495005726 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1340495005727 catalytic residues [active] 1340495005728 catalytic nucleophile [active] 1340495005729 Presynaptic Site I dimer interface [polypeptide binding]; other site 1340495005730 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1340495005731 Synaptic Flat tetramer interface [polypeptide binding]; other site 1340495005732 Synaptic Site I dimer interface [polypeptide binding]; other site 1340495005733 DNA binding site [nucleotide binding] 1340495005734 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1340495005735 Cadmium resistance transporter; Region: Cad; pfam03596 1340495005736 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1340495005737 dimerization interface [polypeptide binding]; other site 1340495005738 putative DNA binding site [nucleotide binding]; other site 1340495005739 putative Zn2+ binding site [ion binding]; other site 1340495005740 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1340495005741 active site 1340495005742 arsenical-resistance protein; Region: acr3; TIGR00832 1340495005743 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1340495005744 dimerization interface [polypeptide binding]; other site 1340495005745 putative DNA binding site [nucleotide binding]; other site 1340495005746 putative Zn2+ binding site [ion binding]; other site 1340495005747 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1340495005748 Initiator Replication protein; Region: Rep_3; pfam01051 1340495005749 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1340495005750 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1340495005751 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1340495005752 salt bridge; other site 1340495005753 non-specific DNA binding site [nucleotide binding]; other site 1340495005754 sequence-specific DNA binding site [nucleotide binding]; other site 1340495005755 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1340495005756 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1340495005757 DNA binding site [nucleotide binding] 1340495005758 Int/Topo IB signature motif; other site 1340495005759 active site 1340495005760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1340495005761 Coenzyme A binding pocket [chemical binding]; other site 1340495005762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1340495005763 Helix-turn-helix domain; Region: HTH_28; pfam13518 1340495005764 putative transposase OrfB; Reviewed; Region: PHA02517 1340495005765 HTH-like domain; Region: HTH_21; pfam13276 1340495005766 Integrase core domain; Region: rve; pfam00665 1340495005767 Integrase core domain; Region: rve_3; pfam13683 1340495005768 YcfA-like protein; Region: YcfA; cl00752 1340495005769 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1340495005770 PGDYG protein; Region: PGDYG; pfam14083 1340495005771 VRR-NUC domain; Region: VRR_NUC; pfam08774 1340495005772 Virulence-associated protein E; Region: VirE; pfam05272 1340495005773 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1340495005774 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1340495005775 polymerase nucleotide-binding site; other site 1340495005776 DNA-binding residues [nucleotide binding]; DNA binding site 1340495005777 nucleotide binding site [chemical binding]; other site 1340495005778 primase nucleotide-binding site [nucleotide binding]; other site 1340495005779 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 1340495005780 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1340495005781 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1340495005782 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1340495005783 ATP binding site [chemical binding]; other site 1340495005784 putative Mg++ binding site [ion binding]; other site 1340495005785 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1340495005786 nucleotide binding region [chemical binding]; other site 1340495005787 ATP-binding site [chemical binding]; other site 1340495005788 Helix-turn-helix domain; Region: HTH_17; cl17695 1340495005789 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 1340495005790 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1340495005791 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1340495005792 sequence-specific DNA binding site [nucleotide binding]; other site 1340495005793 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1340495005794 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1340495005795 non-specific DNA binding site [nucleotide binding]; other site 1340495005796 salt bridge; other site 1340495005797 sequence-specific DNA binding site [nucleotide binding]; other site 1340495005798 Domain of unknown function (DUF955); Region: DUF955; cl01076 1340495005799 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1340495005800 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 1340495005801 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1340495005802 active site 1340495005803 DNA binding site [nucleotide binding] 1340495005804 Int/Topo IB signature motif; other site 1340495005805 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1340495005806 active site 1340495005807 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1340495005808 surface protein repeat Ser-Ala-175; Region: SerAla_Lrha_rpt; TIGR04319 1340495005809 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 1340495005810 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1340495005811 active site 1340495005812 Prophage endopeptidase tail; Region: Prophage_tail; cl19379 1340495005813 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1340495005814 NlpC/P60 family; Region: NLPC_P60; pfam00877 1340495005815 Phage tail protein; Region: Sipho_tail; pfam05709 1340495005816 Phage-related tail protein [Function unknown]; Region: COG5283 1340495005817 tape measure domain; Region: tape_meas_nterm; TIGR02675 1340495005818 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1340495005819 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1340495005820 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1340495005821 catalytic residue [active] 1340495005822 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 1340495005823 Phage major tail protein; Region: Phage_tail; pfam04630 1340495005824 Protein of unknown function (DUF806); Region: DUF806; pfam05657 1340495005825 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; cl12124 1340495005826 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1340495005827 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1340495005828 oligomerization interface [polypeptide binding]; other site 1340495005829 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1340495005830 Phage capsid family; Region: Phage_capsid; pfam05065 1340495005831 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1340495005832 oligomer interface [polypeptide binding]; other site 1340495005833 active site residues [active] 1340495005834 Phage portal protein; Region: Phage_portal; pfam04860 1340495005835 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1340495005836 Phage Terminase; Region: Terminase_1; cl19862 1340495005837 Phage terminase, small subunit; Region: Terminase_4; cl01525 1340495005838 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1340495005839 active site 1340495005840 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1340495005841 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1340495005842 Walker A/P-loop; other site 1340495005843 ATP binding site [chemical binding]; other site 1340495005844 Q-loop/lid; other site 1340495005845 ABC transporter signature motif; other site 1340495005846 Walker B; other site 1340495005847 D-loop; other site 1340495005848 H-loop/switch region; other site 1340495005849 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1340495005850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1340495005851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1340495005852 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1340495005853 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 1340495005854 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1340495005855 Homeodomain-like domain; Region: HTH_23; pfam13384 1340495005856 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1340495005857 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1340495005858 P-loop; other site 1340495005859 Magnesium ion binding site [ion binding]; other site 1340495005860 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1340495005861 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1340495005862 active site 1340495005863 DNA binding site [nucleotide binding] 1340495005864 Int/Topo IB signature motif; other site 1340495005865 CHC2 zinc finger; Region: zf-CHC2; cl17510 1340495005866 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1340495005867 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1340495005868 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1340495005869 active site 1340495005870 metal binding site [ion binding]; metal-binding site 1340495005871 interdomain interaction site; other site 1340495005872 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 1340495005873 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1340495005874 Walker A motif; other site 1340495005875 ATP binding site [chemical binding]; other site 1340495005876 Walker B motif; other site 1340495005877 Replication protein; Region: Rep_1; cl02412 1340495005878 Protein of unknown function DUF262; Region: DUF262; pfam03235 1340495005879 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1340495005880 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1340495005881 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1340495005882 active site 1340495005883 DNA binding site [nucleotide binding] 1340495005884 Int/Topo IB signature motif; other site 1340495005885 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495005886 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495005887 Integrase core domain; Region: rve; pfam00665 1340495005888 Integration host factor (IHF) and similar proteins; Region: IHF; cd13832 1340495005889 dimer interface [polypeptide binding]; other site 1340495005890 DNA binding site [nucleotide binding] 1340495005891 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1340495005892 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1340495005893 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1340495005894 P-loop; other site 1340495005895 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1340495005896 Magnesium ion binding site [ion binding]; other site 1340495005897 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1340495005898 Mg binding site [ion binding]; other site 1340495005899 nucleotide binding site [chemical binding]; other site 1340495005900 putative protofilament interface [polypeptide binding]; other site 1340495005901 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1340495005902 Helix-turn-helix domain; Region: HTH_28; pfam13518 1340495005903 HTH-like domain; Region: HTH_21; pfam13276 1340495005904 Integrase core domain; Region: rve; pfam00665 1340495005905 Integrase core domain; Region: rve_3; cl15866 1340495005906 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1340495005907 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 1340495005908 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1340495005909 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 1340495005910 putative transposase OrfB; Reviewed; Region: PHA02517 1340495005911 HTH-like domain; Region: HTH_21; pfam13276 1340495005912 Integrase core domain; Region: rve; pfam00665 1340495005913 Integrase core domain; Region: rve_3; pfam13683 1340495005914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1340495005915 Transposase; Region: HTH_Tnp_1; cl17663 1340495005916 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1340495005917 active site 1340495005918 catalytic residues [active] 1340495005919 Int/Topo IB signature motif; other site 1340495005920 DNA binding site [nucleotide binding] 1340495005921 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 1340495005922 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495005923 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495005924 Integrase core domain; Region: rve; pfam00665 1340495005925 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1340495005926 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1340495005927 Histidine carboxylase PI chain; Region: HDC; cl03540 1340495005928 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1340495005929 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1340495005930 dimer interface [polypeptide binding]; other site 1340495005931 motif 1; other site 1340495005932 active site 1340495005933 motif 2; other site 1340495005934 motif 3; other site 1340495005935 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1340495005936 anticodon binding site; other site 1340495005937 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1340495005938 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1340495005939 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cl10029 1340495005940 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1340495005941 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1340495005942 active site 1340495005943 DNA binding site [nucleotide binding] 1340495005944 Int/Topo IB signature motif; other site 1340495005945 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1340495005946 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1340495005947 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1340495005948 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 1340495005949 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1340495005950 catalytic residues [active] 1340495005951 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1340495005952 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1340495005953 catalytic residues [active] 1340495005954 catalytic nucleophile [active] 1340495005955 Presynaptic Site I dimer interface [polypeptide binding]; other site 1340495005956 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1340495005957 Synaptic Flat tetramer interface [polypeptide binding]; other site 1340495005958 Synaptic Site I dimer interface [polypeptide binding]; other site 1340495005959 DNA binding site [nucleotide binding] 1340495005960 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1340495005961 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1340495005962 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1340495005963 putative active site [active] 1340495005964 putative NTP binding site [chemical binding]; other site 1340495005965 putative nucleic acid binding site [nucleotide binding]; other site 1340495005966 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1340495005967 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 1340495005968 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1340495005969 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1340495005970 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1340495005971 motif II; other site 1340495005972 Penicillinase repressor; Region: Penicillinase_R; cl17580 1340495005973 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1340495005974 dimerization interface [polypeptide binding]; other site 1340495005975 putative DNA binding site [nucleotide binding]; other site 1340495005976 putative Zn2+ binding site [ion binding]; other site 1340495005977 Cadmium resistance transporter; Region: Cad; pfam03596 1340495005978 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1340495005979 dimerization interface [polypeptide binding]; other site 1340495005980 putative DNA binding site [nucleotide binding]; other site 1340495005981 putative Zn2+ binding site [ion binding]; other site 1340495005982 arsenical-resistance protein; Region: acr3; TIGR00832 1340495005983 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1340495005984 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1340495005985 Helix-turn-helix domain; Region: HTH_38; pfam13936 1340495005986 Integrase core domain; Region: rve; pfam00665 1340495005987 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1340495005988 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1340495005989 G1 box; other site 1340495005990 putative GEF interaction site [polypeptide binding]; other site 1340495005991 GTP/Mg2+ binding site [chemical binding]; other site 1340495005992 Switch I region; other site 1340495005993 G2 box; other site 1340495005994 G3 box; other site 1340495005995 Switch II region; other site 1340495005996 G4 box; other site 1340495005997 G5 box; other site 1340495005998 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1340495005999 Elongation Factor G, domain II; Region: EFG_II; pfam14492 1340495006000 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 1340495006001 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1340495006002 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1340495006003 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1340495006004 non-specific DNA binding site [nucleotide binding]; other site 1340495006005 salt bridge; other site 1340495006006 sequence-specific DNA binding site [nucleotide binding]; other site 1340495006007 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1340495006008 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1340495006009 NAD binding site [chemical binding]; other site 1340495006010 substrate binding site [chemical binding]; other site 1340495006011 catalytic Zn binding site [ion binding]; other site 1340495006012 tetramer interface [polypeptide binding]; other site 1340495006013 structural Zn binding site [ion binding]; other site 1340495006014 Helix-turn-helix domain; Region: HTH_17; pfam12728 1340495006015 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 1340495006016 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 1340495006017 Chloramphenicol acetyltransferase; Region: CAT; cl02008 1340495006018 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1340495006019 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1340495006020 active site 1340495006021 DNA binding site [nucleotide binding] 1340495006022 Int/Topo IB signature motif; other site 1340495006023 RelB antitoxin; Region: RelB; cl01171 1340495006024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1340495006025 hypothetical protein; Provisional; Region: PRK11281 1340495006026 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1340495006027 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1340495006028 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1340495006029 P-loop; other site 1340495006030 Magnesium ion binding site [ion binding]; other site