-- dump date 20140619_124524 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1358027000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1358027000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1358027000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027000004 Walker A motif; other site 1358027000005 ATP binding site [chemical binding]; other site 1358027000006 Walker B motif; other site 1358027000007 arginine finger; other site 1358027000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1358027000009 DnaA box-binding interface [nucleotide binding]; other site 1358027000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1358027000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1358027000012 putative DNA binding surface [nucleotide binding]; other site 1358027000013 dimer interface [polypeptide binding]; other site 1358027000014 beta-clamp/clamp loader binding surface; other site 1358027000015 beta-clamp/translesion DNA polymerase binding surface; other site 1358027000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1358027000017 recombination protein F; Reviewed; Region: recF; PRK00064 1358027000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1358027000019 Walker A/P-loop; other site 1358027000020 ATP binding site [chemical binding]; other site 1358027000021 Q-loop/lid; other site 1358027000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027000023 ABC transporter signature motif; other site 1358027000024 Walker B; other site 1358027000025 D-loop; other site 1358027000026 H-loop/switch region; other site 1358027000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1358027000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1358027000029 Mg2+ binding site [ion binding]; other site 1358027000030 G-X-G motif; other site 1358027000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1358027000032 anchoring element; other site 1358027000033 dimer interface [polypeptide binding]; other site 1358027000034 ATP binding site [chemical binding]; other site 1358027000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1358027000036 active site 1358027000037 putative metal-binding site [ion binding]; other site 1358027000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1358027000039 DNA gyrase subunit A; Validated; Region: PRK05560 1358027000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1358027000041 CAP-like domain; other site 1358027000042 active site 1358027000043 primary dimer interface [polypeptide binding]; other site 1358027000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1358027000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1358027000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1358027000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1358027000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1358027000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1358027000050 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1358027000051 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1358027000052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1358027000053 dimer interface [polypeptide binding]; other site 1358027000054 ssDNA binding site [nucleotide binding]; other site 1358027000055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1358027000056 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1358027000057 DDE superfamily endonuclease; Region: DDE_5; cl17874 1358027000058 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1358027000059 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 1358027000060 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1358027000061 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1358027000062 DHH family; Region: DHH; pfam01368 1358027000063 DHHA1 domain; Region: DHHA1; pfam02272 1358027000064 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1358027000065 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1358027000066 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1358027000067 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1358027000068 replicative DNA helicase; Provisional; Region: PRK05748 1358027000069 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1358027000070 Walker A motif; other site 1358027000071 ATP binding site [chemical binding]; other site 1358027000072 Walker B motif; other site 1358027000073 DNA binding loops [nucleotide binding] 1358027000074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027000075 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1358027000076 putative substrate translocation pore; other site 1358027000077 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1358027000078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1358027000079 non-specific DNA binding site [nucleotide binding]; other site 1358027000080 salt bridge; other site 1358027000081 sequence-specific DNA binding site [nucleotide binding]; other site 1358027000082 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1358027000083 MarR family; Region: MarR_2; pfam12802 1358027000084 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1358027000085 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1358027000086 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027000087 Walker A/P-loop; other site 1358027000088 ATP binding site [chemical binding]; other site 1358027000089 Q-loop/lid; other site 1358027000090 ABC transporter signature motif; other site 1358027000091 Walker B; other site 1358027000092 D-loop; other site 1358027000093 H-loop/switch region; other site 1358027000094 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1358027000095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1358027000096 active site 1358027000097 phosphorylation site [posttranslational modification] 1358027000098 intermolecular recognition site; other site 1358027000099 dimerization interface [polypeptide binding]; other site 1358027000100 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1358027000101 DNA binding site [nucleotide binding] 1358027000102 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1358027000103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1358027000104 dimerization interface [polypeptide binding]; other site 1358027000105 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1358027000106 putative active site [active] 1358027000107 heme pocket [chemical binding]; other site 1358027000108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1358027000109 dimer interface [polypeptide binding]; other site 1358027000110 phosphorylation site [posttranslational modification] 1358027000111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1358027000112 ATP binding site [chemical binding]; other site 1358027000113 Mg2+ binding site [ion binding]; other site 1358027000114 G-X-G motif; other site 1358027000115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1358027000116 YycH protein; Region: YycH; pfam07435 1358027000117 YycH protein; Region: YycI; pfam09648 1358027000118 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1358027000119 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1358027000120 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1358027000121 protein binding site [polypeptide binding]; other site 1358027000122 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1358027000123 tetramer interfaces [polypeptide binding]; other site 1358027000124 binuclear metal-binding site [ion binding]; other site 1358027000125 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1358027000126 zinc binding site [ion binding]; other site 1358027000127 putative ligand binding site [chemical binding]; other site 1358027000128 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1358027000129 Predicted flavoprotein [General function prediction only]; Region: COG0431 1358027000130 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1358027000131 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1358027000132 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1358027000133 dimer interface [polypeptide binding]; other site 1358027000134 active site 1358027000135 metal binding site [ion binding]; metal-binding site 1358027000136 Sugar transport protein; Region: Sugar_transport; pfam06800 1358027000137 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1358027000138 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1358027000139 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1358027000140 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1358027000141 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1358027000142 NAD(P) binding site [chemical binding]; other site 1358027000143 catalytic residues [active] 1358027000144 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1358027000145 HlyD family secretion protein; Region: HlyD_3; pfam13437 1358027000146 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1358027000147 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1358027000148 Walker A/P-loop; other site 1358027000149 ATP binding site [chemical binding]; other site 1358027000150 Q-loop/lid; other site 1358027000151 ABC transporter signature motif; other site 1358027000152 Walker B; other site 1358027000153 D-loop; other site 1358027000154 H-loop/switch region; other site 1358027000155 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1358027000156 FtsX-like permease family; Region: FtsX; pfam02687 1358027000157 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1358027000158 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1358027000159 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1358027000160 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1358027000161 Response regulator receiver domain; Region: Response_reg; pfam00072 1358027000162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1358027000163 active site 1358027000164 phosphorylation site [posttranslational modification] 1358027000165 intermolecular recognition site; other site 1358027000166 dimerization interface [polypeptide binding]; other site 1358027000167 LytTr DNA-binding domain; Region: LytTR; cl04498 1358027000168 OsmC-like protein; Region: OsmC; pfam02566 1358027000169 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1358027000170 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1358027000171 homodimer interface [polypeptide binding]; other site 1358027000172 ligand binding site [chemical binding]; other site 1358027000173 NAD binding site [chemical binding]; other site 1358027000174 catalytic site [active] 1358027000175 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1358027000176 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1358027000177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1358027000178 homodimer interface [polypeptide binding]; other site 1358027000179 catalytic residue [active] 1358027000180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027000181 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1358027000182 Walker A motif; other site 1358027000183 ATP binding site [chemical binding]; other site 1358027000184 Walker B motif; other site 1358027000185 arginine finger; other site 1358027000186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027000187 Walker A motif; other site 1358027000188 ATP binding site [chemical binding]; other site 1358027000189 Walker B motif; other site 1358027000190 arginine finger; other site 1358027000191 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1358027000192 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1358027000193 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1358027000194 active site 1358027000195 octamer interface [polypeptide binding]; other site 1358027000196 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1358027000197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1358027000198 Coenzyme A binding pocket [chemical binding]; other site 1358027000199 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1358027000200 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1358027000201 putative active site [active] 1358027000202 catalytic site [active] 1358027000203 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1358027000204 putative active site [active] 1358027000205 catalytic site [active] 1358027000206 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1358027000207 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1358027000208 Part of AAA domain; Region: AAA_19; pfam13245 1358027000209 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1358027000210 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 1358027000211 Family description; Region: UvrD_C_2; pfam13538 1358027000212 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1358027000213 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1358027000214 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1358027000215 DNA binding site [nucleotide binding] 1358027000216 domain linker motif; other site 1358027000217 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1358027000218 putative dimerization interface [polypeptide binding]; other site 1358027000219 putative ligand binding site [chemical binding]; other site 1358027000220 putative acyltransferase; Provisional; Region: PRK05790 1358027000221 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1358027000222 dimer interface [polypeptide binding]; other site 1358027000223 active site 1358027000224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027000225 putative substrate translocation pore; other site 1358027000226 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1358027000227 maltose phosphorylase; Provisional; Region: PRK13807 1358027000228 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1358027000229 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1358027000230 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1358027000231 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1358027000232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1358027000233 motif II; other site 1358027000234 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1358027000235 synthetase active site [active] 1358027000236 NTP binding site [chemical binding]; other site 1358027000237 metal binding site [ion binding]; metal-binding site 1358027000238 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1358027000239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1358027000240 active site 1358027000241 phosphorylation site [posttranslational modification] 1358027000242 intermolecular recognition site; other site 1358027000243 dimerization interface [polypeptide binding]; other site 1358027000244 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1358027000245 DNA binding site [nucleotide binding] 1358027000246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1358027000247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1358027000248 dimer interface [polypeptide binding]; other site 1358027000249 phosphorylation site [posttranslational modification] 1358027000250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1358027000251 ATP binding site [chemical binding]; other site 1358027000252 Mg2+ binding site [ion binding]; other site 1358027000253 G-X-G motif; other site 1358027000254 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1358027000255 Cl- selectivity filter; other site 1358027000256 Cl- binding residues [ion binding]; other site 1358027000257 pore gating glutamate residue; other site 1358027000258 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1358027000259 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1358027000260 Peptidase C26; Region: Peptidase_C26; pfam07722 1358027000261 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1358027000262 catalytic triad [active] 1358027000263 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1358027000264 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1358027000265 active site 1358027000266 catalytic tetrad [active] 1358027000267 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 1358027000268 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1358027000269 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1358027000270 putative active site [active] 1358027000271 catalytic site [active] 1358027000272 putative metal binding site [ion binding]; other site 1358027000273 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1358027000274 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1358027000275 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1358027000276 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1358027000277 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1358027000278 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1358027000279 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1358027000280 active site 1358027000281 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1358027000282 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1358027000283 GDP-binding site [chemical binding]; other site 1358027000284 ACT binding site; other site 1358027000285 IMP binding site; other site 1358027000286 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1358027000287 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1358027000288 active site 1358027000289 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1358027000290 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1358027000291 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1358027000292 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1358027000293 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1358027000294 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1358027000295 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1358027000296 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1358027000297 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1358027000298 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1358027000299 Ca binding site [ion binding]; other site 1358027000300 active site 1358027000301 catalytic site [active] 1358027000302 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1358027000303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027000304 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1358027000305 putative substrate translocation pore; other site 1358027000306 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1358027000307 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1358027000308 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1358027000309 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1358027000310 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1358027000311 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1358027000312 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 1358027000313 substrate binding site [chemical binding]; other site 1358027000314 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1358027000315 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1358027000316 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1358027000317 catalytic site [active] 1358027000318 subunit interface [polypeptide binding]; other site 1358027000319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027000320 putative substrate translocation pore; other site 1358027000321 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1358027000322 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1358027000323 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1358027000324 DNA binding site [nucleotide binding] 1358027000325 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1358027000326 dimerization interface [polypeptide binding]; other site 1358027000327 ligand binding site [chemical binding]; other site 1358027000328 TRAM domain; Region: TRAM; pfam01938 1358027000329 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1358027000330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1358027000331 S-adenosylmethionine binding site [chemical binding]; other site 1358027000332 Predicted flavoprotein [General function prediction only]; Region: COG0431 1358027000333 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1358027000334 Predicted flavoprotein [General function prediction only]; Region: COG0431 1358027000335 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1358027000336 PAS domain; Region: PAS_10; pfam13596 1358027000337 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1358027000338 ApbE family; Region: ApbE; pfam02424 1358027000339 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1358027000340 Rib/alpha-like repeat; Region: Rib; pfam08428 1358027000341 Rib/alpha-like repeat; Region: Rib; pfam08428 1358027000342 MucBP domain; Region: MucBP; pfam06458 1358027000343 Rib/alpha-like repeat; Region: Rib; pfam08428 1358027000344 Rib/alpha-like repeat; Region: Rib; pfam08428 1358027000345 Rib/alpha-like repeat; Region: Rib; pfam08428 1358027000346 Rib/alpha-like repeat; Region: Rib; pfam08428 1358027000347 Rib/alpha-like repeat; Region: Rib; pfam08428 1358027000348 Rib/alpha-like repeat; Region: Rib; pfam08428 1358027000349 Rib/alpha-like repeat; Region: Rib; pfam08428 1358027000350 Rib/alpha-like repeat; Region: Rib; pfam08428 1358027000351 Rib/alpha-like repeat; Region: Rib; pfam08428 1358027000352 MucBP domain; Region: MucBP; pfam06458 1358027000353 MucBP domain; Region: MucBP; pfam06458 1358027000354 MucBP domain; Region: MucBP; pfam06458 1358027000355 MucBP domain; Region: MucBP; pfam06458 1358027000356 MucBP domain; Region: MucBP; pfam06458 1358027000357 MucBP domain; Region: MucBP; pfam06458 1358027000358 MucBP domain; Region: MucBP; pfam06458 1358027000359 MucBP domain; Region: MucBP; pfam06458 1358027000360 MucBP domain; Region: MucBP; pfam06458 1358027000361 MucBP domain; Region: MucBP; pfam06458 1358027000362 MucBP domain; Region: MucBP; pfam06458 1358027000363 seryl-tRNA synthetase; Provisional; Region: PRK05431 1358027000364 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1358027000365 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1358027000366 dimer interface [polypeptide binding]; other site 1358027000367 active site 1358027000368 motif 1; other site 1358027000369 motif 2; other site 1358027000370 motif 3; other site 1358027000371 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1358027000372 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1358027000373 substrate binding pocket [chemical binding]; other site 1358027000374 membrane-bound complex binding site; other site 1358027000375 hinge residues; other site 1358027000376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1358027000377 dimer interface [polypeptide binding]; other site 1358027000378 conserved gate region; other site 1358027000379 putative PBP binding loops; other site 1358027000380 ABC-ATPase subunit interface; other site 1358027000381 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1358027000382 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1358027000383 Walker A/P-loop; other site 1358027000384 ATP binding site [chemical binding]; other site 1358027000385 Q-loop/lid; other site 1358027000386 ABC transporter signature motif; other site 1358027000387 Walker B; other site 1358027000388 D-loop; other site 1358027000389 H-loop/switch region; other site 1358027000390 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1358027000391 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1358027000392 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1358027000393 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1358027000394 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1358027000395 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1358027000396 active site 1358027000397 tetramer interface [polypeptide binding]; other site 1358027000398 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 1358027000399 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1358027000400 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1358027000401 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1358027000402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1358027000403 S-adenosylmethionine binding site [chemical binding]; other site 1358027000404 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1358027000405 ParB-like nuclease domain; Region: ParBc; pfam02195 1358027000406 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1358027000407 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1358027000408 P-loop; other site 1358027000409 Magnesium ion binding site [ion binding]; other site 1358027000410 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1358027000411 ParB-like nuclease domain; Region: ParB; smart00470 1358027000412 KorB domain; Region: KorB; pfam08535 1358027000413 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1358027000414 GTP-binding protein YchF; Reviewed; Region: PRK09601 1358027000415 YchF GTPase; Region: YchF; cd01900 1358027000416 G1 box; other site 1358027000417 GTP/Mg2+ binding site [chemical binding]; other site 1358027000418 Switch I region; other site 1358027000419 G2 box; other site 1358027000420 Switch II region; other site 1358027000421 G3 box; other site 1358027000422 G4 box; other site 1358027000423 G5 box; other site 1358027000424 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1358027000425 hypothetical protein; Validated; Region: PRK07668 1358027000426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027000427 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1358027000428 intersubunit interface [polypeptide binding]; other site 1358027000429 active site 1358027000430 catalytic residue [active] 1358027000431 phosphopentomutase; Provisional; Region: PRK05362 1358027000432 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1358027000433 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1358027000434 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1358027000435 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1358027000436 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1358027000437 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1358027000438 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1358027000439 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1358027000440 DNA binding residues [nucleotide binding] 1358027000441 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1358027000442 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 1358027000443 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1358027000444 active site 1358027000445 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1358027000446 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1358027000447 dimer interface [polypeptide binding]; other site 1358027000448 phosphorylation site [posttranslational modification] 1358027000449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1358027000450 ATP binding site [chemical binding]; other site 1358027000451 Mg2+ binding site [ion binding]; other site 1358027000452 G-X-G motif; other site 1358027000453 AzlC protein; Region: AzlC; pfam03591 1358027000454 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1358027000455 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1358027000456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1358027000457 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1358027000458 dimerization interface [polypeptide binding]; other site 1358027000459 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1358027000460 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1358027000461 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1358027000462 dihydroorotase; Validated; Region: pyrC; PRK09357 1358027000463 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1358027000464 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1358027000465 active site 1358027000466 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1358027000467 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1358027000468 heterodimer interface [polypeptide binding]; other site 1358027000469 active site 1358027000470 FMN binding site [chemical binding]; other site 1358027000471 homodimer interface [polypeptide binding]; other site 1358027000472 substrate binding site [chemical binding]; other site 1358027000473 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1358027000474 active site 1358027000475 dimer interface [polypeptide binding]; other site 1358027000476 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1358027000477 active site 1358027000478 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1358027000479 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1358027000480 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1358027000481 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1358027000482 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1358027000483 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1358027000484 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1358027000485 Potassium binding sites [ion binding]; other site 1358027000486 Cesium cation binding sites [ion binding]; other site 1358027000487 acetolactate synthase; Reviewed; Region: PRK08617 1358027000488 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1358027000489 PYR/PP interface [polypeptide binding]; other site 1358027000490 dimer interface [polypeptide binding]; other site 1358027000491 TPP binding site [chemical binding]; other site 1358027000492 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1358027000493 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1358027000494 TPP-binding site [chemical binding]; other site 1358027000495 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1358027000496 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1358027000497 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1358027000498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1358027000499 catalytic residue [active] 1358027000500 homoserine dehydrogenase; Provisional; Region: PRK06349 1358027000501 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1358027000502 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1358027000503 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1358027000504 homoserine kinase; Provisional; Region: PRK01212 1358027000505 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1358027000506 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1358027000507 AIR carboxylase; Region: AIRC; pfam00731 1358027000508 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1358027000509 ATP-grasp domain; Region: ATP-grasp; pfam02222 1358027000510 adenylosuccinate lyase; Provisional; Region: PRK07492 1358027000511 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1358027000512 tetramer interface [polypeptide binding]; other site 1358027000513 active site 1358027000514 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1358027000515 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1358027000516 putative active site [active] 1358027000517 putative NTP binding site [chemical binding]; other site 1358027000518 putative nucleic acid binding site [nucleotide binding]; other site 1358027000519 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1358027000520 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1358027000521 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1358027000522 ATP binding site [chemical binding]; other site 1358027000523 active site 1358027000524 substrate binding site [chemical binding]; other site 1358027000525 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1358027000526 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1358027000527 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1358027000528 putative active site [active] 1358027000529 catalytic triad [active] 1358027000530 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1358027000531 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1358027000532 dimerization interface [polypeptide binding]; other site 1358027000533 ATP binding site [chemical binding]; other site 1358027000534 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1358027000535 dimerization interface [polypeptide binding]; other site 1358027000536 ATP binding site [chemical binding]; other site 1358027000537 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1358027000538 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1358027000539 active site 1358027000540 tetramer interface [polypeptide binding]; other site 1358027000541 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1358027000542 active site 1358027000543 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1358027000544 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1358027000545 dimerization interface [polypeptide binding]; other site 1358027000546 putative ATP binding site [chemical binding]; other site 1358027000547 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1358027000548 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1358027000549 active site 1358027000550 substrate binding site [chemical binding]; other site 1358027000551 cosubstrate binding site; other site 1358027000552 catalytic site [active] 1358027000553 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1358027000554 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1358027000555 purine monophosphate binding site [chemical binding]; other site 1358027000556 dimer interface [polypeptide binding]; other site 1358027000557 putative catalytic residues [active] 1358027000558 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1358027000559 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1358027000560 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1358027000561 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1358027000562 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1358027000563 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1358027000564 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1358027000565 catalytic core [active] 1358027000566 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1358027000567 Protein of unknown function (DUF975); Region: DUF975; cl10504 1358027000568 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1358027000569 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1358027000570 active site 1358027000571 HIGH motif; other site 1358027000572 dimer interface [polypeptide binding]; other site 1358027000573 KMSKS motif; other site 1358027000574 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1358027000575 RNA binding surface [nucleotide binding]; other site 1358027000576 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1358027000577 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1358027000578 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1358027000579 ATP binding site [chemical binding]; other site 1358027000580 putative Mg++ binding site [ion binding]; other site 1358027000581 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1358027000582 nucleotide binding region [chemical binding]; other site 1358027000583 ATP-binding site [chemical binding]; other site 1358027000584 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1358027000585 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1358027000586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1358027000587 S-adenosylmethionine binding site [chemical binding]; other site 1358027000588 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1358027000589 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1358027000590 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1358027000591 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1358027000592 Divergent AAA domain; Region: AAA_4; pfam04326 1358027000593 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1358027000594 classical (c) SDRs; Region: SDR_c; cd05233 1358027000595 NAD(P) binding site [chemical binding]; other site 1358027000596 active site 1358027000597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1358027000598 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1358027000599 NAD(P) binding site [chemical binding]; other site 1358027000600 active site 1358027000601 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 1358027000602 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1358027000603 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1358027000604 Cation efflux family; Region: Cation_efflux; pfam01545 1358027000605 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1358027000606 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1358027000607 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1358027000608 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1358027000609 triosephosphate isomerase; Provisional; Region: PRK14565 1358027000610 substrate binding site [chemical binding]; other site 1358027000611 dimer interface [polypeptide binding]; other site 1358027000612 catalytic triad [active] 1358027000613 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1358027000614 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1358027000615 active site 1358027000616 catalytic tetrad [active] 1358027000617 PAP2 superfamily; Region: PAP2; pfam01569 1358027000618 active site 1358027000619 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1358027000620 PLD-like domain; Region: PLDc_2; pfam13091 1358027000621 putative homodimer interface [polypeptide binding]; other site 1358027000622 putative active site [active] 1358027000623 catalytic site [active] 1358027000624 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1358027000625 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1358027000626 ATP binding site [chemical binding]; other site 1358027000627 putative Mg++ binding site [ion binding]; other site 1358027000628 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1358027000629 nucleotide binding region [chemical binding]; other site 1358027000630 ATP-binding site [chemical binding]; other site 1358027000631 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1358027000632 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1358027000633 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1358027000634 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1358027000635 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 1358027000636 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 1358027000637 active site 1358027000638 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1358027000639 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1358027000640 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1358027000641 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 1358027000642 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1358027000643 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1358027000644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1358027000645 NAD(P) binding site [chemical binding]; other site 1358027000646 active site 1358027000647 Predicted transcriptional regulator [Transcription]; Region: COG1959 1358027000648 Transcriptional regulator; Region: Rrf2; pfam02082 1358027000649 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1358027000650 TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes:...; Region: TBP_TLF; cl08263 1358027000651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1358027000652 dimer interface [polypeptide binding]; other site 1358027000653 conserved gate region; other site 1358027000654 ABC-ATPase subunit interface; other site 1358027000655 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1358027000656 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1358027000657 Walker A/P-loop; other site 1358027000658 ATP binding site [chemical binding]; other site 1358027000659 Q-loop/lid; other site 1358027000660 ABC transporter signature motif; other site 1358027000661 Walker B; other site 1358027000662 D-loop; other site 1358027000663 H-loop/switch region; other site 1358027000664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1358027000665 dimer interface [polypeptide binding]; other site 1358027000666 conserved gate region; other site 1358027000667 ABC-ATPase subunit interface; other site 1358027000668 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1358027000669 SelR domain; Region: SelR; pfam01641 1358027000670 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1358027000671 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1358027000672 Cl- selectivity filter; other site 1358027000673 Cl- binding residues [ion binding]; other site 1358027000674 pore gating glutamate residue; other site 1358027000675 dimer interface [polypeptide binding]; other site 1358027000676 H+/Cl- coupling transport residue; other site 1358027000677 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1358027000678 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1358027000679 metal binding site [ion binding]; metal-binding site 1358027000680 dimer interface [polypeptide binding]; other site 1358027000681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1358027000682 ABC-ATPase subunit interface; other site 1358027000683 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1358027000684 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1358027000685 Walker A/P-loop; other site 1358027000686 ATP binding site [chemical binding]; other site 1358027000687 Q-loop/lid; other site 1358027000688 ABC transporter signature motif; other site 1358027000689 Walker B; other site 1358027000690 D-loop; other site 1358027000691 H-loop/switch region; other site 1358027000692 NIL domain; Region: NIL; pfam09383 1358027000693 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1358027000694 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1358027000695 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1358027000696 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1358027000697 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1358027000698 NAD binding site [chemical binding]; other site 1358027000699 dimer interface [polypeptide binding]; other site 1358027000700 substrate binding site [chemical binding]; other site 1358027000701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027000702 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1358027000703 putative substrate translocation pore; other site 1358027000704 FMN-binding domain; Region: FMN_bind; cl01081 1358027000705 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1358027000706 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1358027000707 minor groove reading motif; other site 1358027000708 helix-hairpin-helix signature motif; other site 1358027000709 substrate binding pocket [chemical binding]; other site 1358027000710 active site 1358027000711 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1358027000712 amino acid transporter; Region: 2A0306; TIGR00909 1358027000713 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1358027000714 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 1358027000715 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1358027000716 inhibitor-cofactor binding pocket; inhibition site 1358027000717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1358027000718 catalytic residue [active] 1358027000719 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1358027000720 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1358027000721 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1358027000722 Part of AAA domain; Region: AAA_19; pfam13245 1358027000723 Family description; Region: UvrD_C_2; pfam13538 1358027000724 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1358027000725 active site 1358027000726 multimer interface [polypeptide binding]; other site 1358027000727 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1358027000728 DNA methylase; Region: N6_N4_Mtase; cl17433 1358027000729 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1358027000730 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1358027000731 active site 1358027000732 HIGH motif; other site 1358027000733 dimer interface [polypeptide binding]; other site 1358027000734 KMSKS motif; other site 1358027000735 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1358027000736 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1358027000737 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1358027000738 homodimer interface [polypeptide binding]; other site 1358027000739 catalytic residues [active] 1358027000740 NAD binding site [chemical binding]; other site 1358027000741 substrate binding pocket [chemical binding]; other site 1358027000742 flexible flap; other site 1358027000743 NAD-dependent deacetylase; Provisional; Region: PRK00481 1358027000744 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 1358027000745 NAD+ binding site [chemical binding]; other site 1358027000746 substrate binding site [chemical binding]; other site 1358027000747 putative Zn binding site [ion binding]; other site 1358027000748 Protein of unknown function DUF72; Region: DUF72; pfam01904 1358027000749 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1358027000750 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1358027000751 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1358027000752 HIGH motif; other site 1358027000753 active site 1358027000754 KMSKS motif; other site 1358027000755 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1358027000756 tRNA binding surface [nucleotide binding]; other site 1358027000757 anticodon binding site; other site 1358027000758 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1358027000759 dimer interface [polypeptide binding]; other site 1358027000760 putative tRNA-binding site [nucleotide binding]; other site 1358027000761 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1358027000762 active site 1358027000763 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1358027000764 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1358027000765 putative active site [active] 1358027000766 putative metal binding site [ion binding]; other site 1358027000767 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1358027000768 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1358027000769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1358027000770 S-adenosylmethionine binding site [chemical binding]; other site 1358027000771 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1358027000772 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1358027000773 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1358027000774 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1358027000775 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 1358027000776 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1358027000777 metal binding site [ion binding]; metal-binding site 1358027000778 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1358027000779 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1358027000780 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1358027000781 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1358027000782 pur operon repressor; Provisional; Region: PRK09213 1358027000783 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1358027000784 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1358027000785 active site 1358027000786 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1358027000787 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1358027000788 Substrate binding site; other site 1358027000789 Mg++ binding site; other site 1358027000790 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1358027000791 active site 1358027000792 substrate binding site [chemical binding]; other site 1358027000793 CoA binding site [chemical binding]; other site 1358027000794 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1358027000795 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1358027000796 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1358027000797 active site 1358027000798 sugar phosphate phosphatase; Provisional; Region: PRK10513 1358027000799 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1358027000800 active site 1358027000801 motif I; other site 1358027000802 motif II; other site 1358027000803 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1358027000804 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1358027000805 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1358027000806 Zn2+ binding site [ion binding]; other site 1358027000807 Mg2+ binding site [ion binding]; other site 1358027000808 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1358027000809 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1358027000810 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1358027000811 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1358027000812 Probable transposase; Region: OrfB_IS605; pfam01385 1358027000813 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1358027000814 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1358027000815 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1358027000816 CTP synthetase; Validated; Region: pyrG; PRK05380 1358027000817 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1358027000818 Catalytic site [active] 1358027000819 active site 1358027000820 UTP binding site [chemical binding]; other site 1358027000821 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1358027000822 active site 1358027000823 putative oxyanion hole; other site 1358027000824 catalytic triad [active] 1358027000825 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1358027000826 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1358027000827 hinge; other site 1358027000828 active site 1358027000829 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1358027000830 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1358027000831 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1358027000832 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1358027000833 active site 1358027000834 catalytic site [active] 1358027000835 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1358027000836 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1358027000837 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1358027000838 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1358027000839 Right handed beta helix region; Region: Beta_helix; pfam13229 1358027000840 Right handed beta helix region; Region: Beta_helix; pfam13229 1358027000841 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1358027000842 triosephosphate isomerase; Provisional; Region: PRK14565 1358027000843 substrate binding site [chemical binding]; other site 1358027000844 dimer interface [polypeptide binding]; other site 1358027000845 catalytic triad [active] 1358027000846 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1358027000847 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1358027000848 intersubunit interface [polypeptide binding]; other site 1358027000849 active site 1358027000850 zinc binding site [ion binding]; other site 1358027000851 Na+ binding site [ion binding]; other site 1358027000852 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1358027000853 catalytic core [active] 1358027000854 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1358027000855 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1358027000856 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1358027000857 active site 1358027000858 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1358027000859 heat shock protein HtpX; Provisional; Region: PRK04897 1358027000860 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1358027000861 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1358027000862 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1358027000863 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1358027000864 helicase 45; Provisional; Region: PTZ00424 1358027000865 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1358027000866 ATP binding site [chemical binding]; other site 1358027000867 Mg++ binding site [ion binding]; other site 1358027000868 motif III; other site 1358027000869 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1358027000870 nucleotide binding region [chemical binding]; other site 1358027000871 ATP-binding site [chemical binding]; other site 1358027000872 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1358027000873 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1358027000874 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1358027000875 DltD N-terminal region; Region: DltD_N; pfam04915 1358027000876 DltD central region; Region: DltD_M; pfam04918 1358027000877 DltD C-terminal region; Region: DltD_C; pfam04914 1358027000878 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1358027000879 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1358027000880 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1358027000881 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1358027000882 acyl-activating enzyme (AAE) consensus motif; other site 1358027000883 AMP binding site [chemical binding]; other site 1358027000884 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1358027000885 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1358027000886 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1358027000887 alanine racemase; Reviewed; Region: alr; PRK00053 1358027000888 active site 1358027000889 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1358027000890 dimer interface [polypeptide binding]; other site 1358027000891 substrate binding site [chemical binding]; other site 1358027000892 catalytic residues [active] 1358027000893 PemK-like protein; Region: PemK; pfam02452 1358027000894 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1358027000895 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1358027000896 Na binding site [ion binding]; other site 1358027000897 cytosine deaminase; Provisional; Region: PRK09230 1358027000898 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1358027000899 active site 1358027000900 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1358027000901 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1358027000902 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1358027000903 putative active site [active] 1358027000904 catalytic residue [active] 1358027000905 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1358027000906 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1358027000907 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1358027000908 ATP binding site [chemical binding]; other site 1358027000909 putative Mg++ binding site [ion binding]; other site 1358027000910 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1358027000911 nucleotide binding region [chemical binding]; other site 1358027000912 ATP-binding site [chemical binding]; other site 1358027000913 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1358027000914 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1358027000915 RNA binding surface [nucleotide binding]; other site 1358027000916 Septum formation initiator; Region: DivIC; cl17659 1358027000917 hypothetical protein; Provisional; Region: PRK08582 1358027000918 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1358027000919 RNA binding site [nucleotide binding]; other site 1358027000920 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1358027000921 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1358027000922 Ligand Binding Site [chemical binding]; other site 1358027000923 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1358027000924 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1358027000925 active site 1358027000926 FtsH Extracellular; Region: FtsH_ext; pfam06480 1358027000927 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1358027000928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027000929 Walker A motif; other site 1358027000930 ATP binding site [chemical binding]; other site 1358027000931 Walker B motif; other site 1358027000932 arginine finger; other site 1358027000933 Peptidase family M41; Region: Peptidase_M41; pfam01434 1358027000934 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1358027000935 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1358027000936 dimerization interface [polypeptide binding]; other site 1358027000937 domain crossover interface; other site 1358027000938 redox-dependent activation switch; other site 1358027000939 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1358027000940 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1358027000941 FMN binding site [chemical binding]; other site 1358027000942 active site 1358027000943 catalytic residues [active] 1358027000944 substrate binding site [chemical binding]; other site 1358027000945 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1358027000946 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1358027000947 dimer interface [polypeptide binding]; other site 1358027000948 putative anticodon binding site; other site 1358027000949 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1358027000950 motif 1; other site 1358027000951 active site 1358027000952 motif 2; other site 1358027000953 motif 3; other site 1358027000954 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 1358027000955 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1358027000956 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1358027000957 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1358027000958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1358027000959 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1358027000960 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1358027000961 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1358027000962 non-specific DNA binding site [nucleotide binding]; other site 1358027000963 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1358027000964 salt bridge; other site 1358027000965 sequence-specific DNA binding site [nucleotide binding]; other site 1358027000966 Bacterial lipoprotein; Region: DUF3642; pfam12182 1358027000967 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1358027000968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027000969 POT family; Region: PTR2; cl17359 1358027000970 putative phosphoesterase; Region: acc_ester; TIGR03729 1358027000971 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1358027000972 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 1358027000973 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1358027000974 TrkA-C domain; Region: TrkA_C; pfam02080 1358027000975 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1358027000976 aspartate racemase; Region: asp_race; TIGR00035 1358027000977 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1358027000978 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1358027000979 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1358027000980 DNA-binding site [nucleotide binding]; DNA binding site 1358027000981 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1358027000982 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1358027000983 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1358027000984 active site 1358027000985 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1358027000986 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1358027000987 homodimer interface [polypeptide binding]; other site 1358027000988 NAD binding pocket [chemical binding]; other site 1358027000989 ATP binding pocket [chemical binding]; other site 1358027000990 Mg binding site [ion binding]; other site 1358027000991 active-site loop [active] 1358027000992 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1358027000993 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1358027000994 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1358027000995 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1358027000996 RNA binding site [nucleotide binding]; other site 1358027000997 hypothetical protein; Provisional; Region: PRK04351 1358027000998 SprT homologues; Region: SprT; cl01182 1358027000999 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1358027001000 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1358027001001 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1358027001002 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1358027001003 Predicted integral membrane protein [Function unknown]; Region: COG5617 1358027001004 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1358027001005 catalytic core [active] 1358027001006 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1358027001007 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1358027001008 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1358027001009 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1358027001010 homodimer interface [polypeptide binding]; other site 1358027001011 substrate-cofactor binding pocket; other site 1358027001012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1358027001013 catalytic residue [active] 1358027001014 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1358027001015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1358027001016 dimer interface [polypeptide binding]; other site 1358027001017 conserved gate region; other site 1358027001018 putative PBP binding loops; other site 1358027001019 ABC-ATPase subunit interface; other site 1358027001020 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1358027001021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027001022 Walker A/P-loop; other site 1358027001023 ATP binding site [chemical binding]; other site 1358027001024 Q-loop/lid; other site 1358027001025 ABC transporter signature motif; other site 1358027001026 Walker B; other site 1358027001027 D-loop; other site 1358027001028 H-loop/switch region; other site 1358027001029 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1358027001030 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1358027001031 substrate binding pocket [chemical binding]; other site 1358027001032 membrane-bound complex binding site; other site 1358027001033 hinge residues; other site 1358027001034 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1358027001035 trimer interface [polypeptide binding]; other site 1358027001036 active site 1358027001037 G bulge; other site 1358027001038 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1358027001039 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1358027001040 active site 1358027001041 dimer interface [polypeptide binding]; other site 1358027001042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1358027001043 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1358027001044 Coenzyme A binding pocket [chemical binding]; other site 1358027001045 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1358027001046 trimer interface [polypeptide binding]; other site 1358027001047 active site 1358027001048 DNA repair protein RadA; Provisional; Region: PRK11823 1358027001049 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1358027001050 Walker A motif/ATP binding site; other site 1358027001051 ATP binding site [chemical binding]; other site 1358027001052 Walker B motif; other site 1358027001053 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1358027001054 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1358027001055 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1358027001056 putative active site [active] 1358027001057 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1358027001058 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1358027001059 active site 1358027001060 HIGH motif; other site 1358027001061 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1358027001062 KMSKS motif; other site 1358027001063 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1358027001064 tRNA binding surface [nucleotide binding]; other site 1358027001065 anticodon binding site; other site 1358027001066 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1358027001067 active site 1358027001068 metal binding site [ion binding]; metal-binding site 1358027001069 dimerization interface [polypeptide binding]; other site 1358027001070 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1358027001071 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1358027001072 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1358027001073 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1358027001074 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1358027001075 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1358027001076 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1358027001077 putative homodimer interface [polypeptide binding]; other site 1358027001078 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1358027001079 heterodimer interface [polypeptide binding]; other site 1358027001080 homodimer interface [polypeptide binding]; other site 1358027001081 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1358027001082 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1358027001083 23S rRNA interface [nucleotide binding]; other site 1358027001084 L7/L12 interface [polypeptide binding]; other site 1358027001085 putative thiostrepton binding site; other site 1358027001086 L25 interface [polypeptide binding]; other site 1358027001087 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1358027001088 mRNA/rRNA interface [nucleotide binding]; other site 1358027001089 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1358027001090 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1358027001091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1358027001092 homodimer interface [polypeptide binding]; other site 1358027001093 catalytic residue [active] 1358027001094 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1358027001095 N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; Region: GlcNAc-1-P_transferase; cd06436 1358027001096 DXD motif; other site 1358027001097 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1358027001098 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1358027001099 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1358027001100 active site 1358027001101 homodimer interface [polypeptide binding]; other site 1358027001102 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1358027001103 23S rRNA interface [nucleotide binding]; other site 1358027001104 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1358027001105 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1358027001106 peripheral dimer interface [polypeptide binding]; other site 1358027001107 core dimer interface [polypeptide binding]; other site 1358027001108 L10 interface [polypeptide binding]; other site 1358027001109 L11 interface [polypeptide binding]; other site 1358027001110 putative EF-Tu interaction site [polypeptide binding]; other site 1358027001111 putative EF-G interaction site [polypeptide binding]; other site 1358027001112 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1358027001113 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1358027001114 Predicted transcriptional regulators [Transcription]; Region: COG1695 1358027001115 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1358027001116 Predicted membrane protein [Function unknown]; Region: COG4709 1358027001117 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1358027001118 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1358027001119 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1358027001120 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1358027001121 putative catalytic cysteine [active] 1358027001122 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1358027001123 putative active site [active] 1358027001124 metal binding site [ion binding]; metal-binding site 1358027001125 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1358027001126 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1358027001127 dimer interface [polypeptide binding]; other site 1358027001128 putative radical transfer pathway; other site 1358027001129 diiron center [ion binding]; other site 1358027001130 tyrosyl radical; other site 1358027001131 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 1358027001132 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1358027001133 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1358027001134 active site 1358027001135 dimer interface [polypeptide binding]; other site 1358027001136 catalytic residues [active] 1358027001137 effector binding site; other site 1358027001138 R2 peptide binding site; other site 1358027001139 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1358027001140 catalytic residues [active] 1358027001141 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1358027001142 nucleoside/Zn binding site; other site 1358027001143 dimer interface [polypeptide binding]; other site 1358027001144 catalytic motif [active] 1358027001145 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1358027001146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027001147 Walker A motif; other site 1358027001148 ATP binding site [chemical binding]; other site 1358027001149 Walker B motif; other site 1358027001150 arginine finger; other site 1358027001151 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1358027001152 hypothetical protein; Validated; Region: PRK00153 1358027001153 recombination protein RecR; Reviewed; Region: recR; PRK00076 1358027001154 RecR protein; Region: RecR; pfam02132 1358027001155 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1358027001156 putative active site [active] 1358027001157 putative metal-binding site [ion binding]; other site 1358027001158 tetramer interface [polypeptide binding]; other site 1358027001159 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1358027001160 thymidylate kinase; Validated; Region: tmk; PRK00698 1358027001161 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1358027001162 TMP-binding site; other site 1358027001163 ATP-binding site [chemical binding]; other site 1358027001164 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1358027001165 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1358027001166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027001167 Walker A motif; other site 1358027001168 ATP binding site [chemical binding]; other site 1358027001169 Walker B motif; other site 1358027001170 arginine finger; other site 1358027001171 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1358027001172 Predicted methyltransferases [General function prediction only]; Region: COG0313 1358027001173 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1358027001174 putative SAM binding site [chemical binding]; other site 1358027001175 putative homodimer interface [polypeptide binding]; other site 1358027001176 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 1358027001177 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1358027001178 active site 2 [active] 1358027001179 active site 1 [active] 1358027001180 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1358027001181 active site 1358027001182 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1358027001183 polyphosphate kinase; Provisional; Region: PRK05443 1358027001184 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1358027001185 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1358027001186 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1358027001187 putative domain interface [polypeptide binding]; other site 1358027001188 putative active site [active] 1358027001189 catalytic site [active] 1358027001190 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1358027001191 putative domain interface [polypeptide binding]; other site 1358027001192 putative active site [active] 1358027001193 catalytic site [active] 1358027001194 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1358027001195 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1358027001196 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1358027001197 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1358027001198 NAD binding site [chemical binding]; other site 1358027001199 homodimer interface [polypeptide binding]; other site 1358027001200 active site 1358027001201 substrate binding site [chemical binding]; other site 1358027001202 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1358027001203 Glycoprotease family; Region: Peptidase_M22; pfam00814 1358027001204 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1358027001205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1358027001206 Coenzyme A binding pocket [chemical binding]; other site 1358027001207 UGMP family protein; Validated; Region: PRK09604 1358027001208 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1358027001209 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1358027001210 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1358027001211 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1358027001212 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1358027001213 putative catalytic cysteine [active] 1358027001214 gamma-glutamyl kinase; Provisional; Region: PRK05429 1358027001215 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1358027001216 nucleotide binding site [chemical binding]; other site 1358027001217 homotetrameric interface [polypeptide binding]; other site 1358027001218 putative phosphate binding site [ion binding]; other site 1358027001219 putative allosteric binding site; other site 1358027001220 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1358027001221 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1358027001222 putative active site [active] 1358027001223 catalytic triad [active] 1358027001224 putative dimer interface [polypeptide binding]; other site 1358027001225 transaminase; Reviewed; Region: PRK08068 1358027001226 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1358027001227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1358027001228 homodimer interface [polypeptide binding]; other site 1358027001229 catalytic residue [active] 1358027001230 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 1358027001231 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1358027001232 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1358027001233 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1358027001234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027001235 Walker A/P-loop; other site 1358027001236 ATP binding site [chemical binding]; other site 1358027001237 Q-loop/lid; other site 1358027001238 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1358027001239 ABC transporter signature motif; other site 1358027001240 Walker B; other site 1358027001241 D-loop; other site 1358027001242 ABC transporter; Region: ABC_tran_2; pfam12848 1358027001243 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1358027001244 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1358027001245 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1358027001246 CoA binding domain; Region: CoA_binding; pfam02629 1358027001247 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1358027001248 oligomerisation interface [polypeptide binding]; other site 1358027001249 mobile loop; other site 1358027001250 roof hairpin; other site 1358027001251 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1358027001252 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1358027001253 ring oligomerisation interface [polypeptide binding]; other site 1358027001254 ATP/Mg binding site [chemical binding]; other site 1358027001255 stacking interactions; other site 1358027001256 hinge regions; other site 1358027001257 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1358027001258 putative deacylase active site [active] 1358027001259 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1358027001260 Amino acid permease; Region: AA_permease_2; pfam13520 1358027001261 K+ potassium transporter; Region: K_trans; cl15781 1358027001262 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1358027001263 MarR family; Region: MarR_2; pfam12802 1358027001264 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1358027001265 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1358027001266 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1358027001267 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1358027001268 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1358027001269 ATP binding site [chemical binding]; other site 1358027001270 putative Mg++ binding site [ion binding]; other site 1358027001271 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1358027001272 nucleotide binding region [chemical binding]; other site 1358027001273 ATP-binding site [chemical binding]; other site 1358027001274 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1358027001275 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1358027001276 active site 1358027001277 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1358027001278 30S subunit binding site; other site 1358027001279 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 1358027001280 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1358027001281 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1358027001282 nucleotide binding region [chemical binding]; other site 1358027001283 ATP-binding site [chemical binding]; other site 1358027001284 peptide chain release factor 2; Provisional; Region: PRK05589 1358027001285 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1358027001286 RF-1 domain; Region: RF-1; pfam00472 1358027001287 PspC domain; Region: PspC; pfam04024 1358027001288 Membrane protein of unknown function; Region: DUF360; pfam04020 1358027001289 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1358027001290 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1358027001291 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1358027001292 Hpr binding site; other site 1358027001293 active site 1358027001294 homohexamer subunit interaction site [polypeptide binding]; other site 1358027001295 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1358027001296 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1358027001297 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1358027001298 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1358027001299 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1358027001300 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1358027001301 active site 1358027001302 tetramer interface; other site 1358027001303 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1358027001304 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1358027001305 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1358027001306 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1358027001307 Cysteine-rich domain; Region: CCG; pfam02754 1358027001308 Cysteine-rich domain; Region: CCG; pfam02754 1358027001309 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1358027001310 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1358027001311 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1358027001312 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1358027001313 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1358027001314 metal binding site [ion binding]; metal-binding site 1358027001315 dimer interface [polypeptide binding]; other site 1358027001316 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1358027001317 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1358027001318 substrate binding pocket [chemical binding]; other site 1358027001319 membrane-bound complex binding site; other site 1358027001320 hinge residues; other site 1358027001321 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1358027001322 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1358027001323 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1358027001324 active site 1358027001325 substrate binding site [chemical binding]; other site 1358027001326 metal binding site [ion binding]; metal-binding site 1358027001327 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1358027001328 Zn2+ binding site [ion binding]; other site 1358027001329 Mg2+ binding site [ion binding]; other site 1358027001330 excinuclease ABC subunit B; Provisional; Region: PRK05298 1358027001331 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1358027001332 ATP binding site [chemical binding]; other site 1358027001333 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1358027001334 nucleotide binding region [chemical binding]; other site 1358027001335 ATP-binding site [chemical binding]; other site 1358027001336 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1358027001337 UvrB/uvrC motif; Region: UVR; pfam02151 1358027001338 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1358027001339 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1358027001340 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1358027001341 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1358027001342 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1358027001343 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1358027001344 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1358027001345 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1358027001346 phosphate binding site [ion binding]; other site 1358027001347 putative substrate binding pocket [chemical binding]; other site 1358027001348 dimer interface [polypeptide binding]; other site 1358027001349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1358027001350 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1358027001351 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1358027001352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027001353 putative substrate translocation pore; other site 1358027001354 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1358027001355 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1358027001356 oligomer interface [polypeptide binding]; other site 1358027001357 active site residues [active] 1358027001358 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1358027001359 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1358027001360 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1358027001361 Phosphoglycerate kinase; Region: PGK; pfam00162 1358027001362 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1358027001363 substrate binding site [chemical binding]; other site 1358027001364 hinge regions; other site 1358027001365 ADP binding site [chemical binding]; other site 1358027001366 catalytic site [active] 1358027001367 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1358027001368 triosephosphate isomerase; Provisional; Region: PRK14565 1358027001369 substrate binding site [chemical binding]; other site 1358027001370 dimer interface [polypeptide binding]; other site 1358027001371 catalytic triad [active] 1358027001372 enolase; Provisional; Region: eno; PRK00077 1358027001373 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1358027001374 dimer interface [polypeptide binding]; other site 1358027001375 metal binding site [ion binding]; metal-binding site 1358027001376 substrate binding pocket [chemical binding]; other site 1358027001377 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1358027001378 DDE superfamily endonuclease; Region: DDE_5; cl17874 1358027001379 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1358027001380 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 1358027001381 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1358027001382 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1358027001383 Cl- selectivity filter; other site 1358027001384 Cl- binding residues [ion binding]; other site 1358027001385 pore gating glutamate residue; other site 1358027001386 dimer interface [polypeptide binding]; other site 1358027001387 H+/Cl- coupling transport residue; other site 1358027001388 TrkA-C domain; Region: TrkA_C; pfam02080 1358027001389 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1358027001390 Esterase/lipase [General function prediction only]; Region: COG1647 1358027001391 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1358027001392 ribonuclease R; Region: RNase_R; TIGR02063 1358027001393 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1358027001394 RNB domain; Region: RNB; pfam00773 1358027001395 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1358027001396 RNA binding site [nucleotide binding]; other site 1358027001397 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1358027001398 SmpB-tmRNA interface; other site 1358027001399 Tubby C 2; Region: Tub_2; cl02043 1358027001400 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1358027001401 ligand binding site [chemical binding]; other site 1358027001402 active site 1358027001403 UGI interface [polypeptide binding]; other site 1358027001404 catalytic site [active] 1358027001405 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1358027001406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1358027001407 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1358027001408 Coenzyme A binding pocket [chemical binding]; other site 1358027001409 PAS domain; Region: PAS_10; pfam13596 1358027001410 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1358027001411 active site 1358027001412 catalytic site [active] 1358027001413 substrate binding site [chemical binding]; other site 1358027001414 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1358027001415 FAD binding domain; Region: FAD_binding_4; pfam01565 1358027001416 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1358027001417 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1358027001418 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1358027001419 substrate binding site [chemical binding]; other site 1358027001420 dimer interface [polypeptide binding]; other site 1358027001421 ATP binding site [chemical binding]; other site 1358027001422 D-ribose pyranase; Provisional; Region: PRK11797 1358027001423 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1358027001424 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1358027001425 YbbR-like protein; Region: YbbR; pfam07949 1358027001426 YbbR-like protein; Region: YbbR; pfam07949 1358027001427 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1358027001428 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1358027001429 active site 1358027001430 substrate binding site [chemical binding]; other site 1358027001431 metal binding site [ion binding]; metal-binding site 1358027001432 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1358027001433 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1358027001434 glutaminase active site [active] 1358027001435 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1358027001436 dimer interface [polypeptide binding]; other site 1358027001437 active site 1358027001438 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1358027001439 dimer interface [polypeptide binding]; other site 1358027001440 active site 1358027001441 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1358027001442 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1358027001443 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1358027001444 catalytic triad [active] 1358027001445 catalytic triad [active] 1358027001446 oxyanion hole [active] 1358027001447 MarR family; Region: MarR_2; pfam12802 1358027001448 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1358027001449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1358027001450 active site 1358027001451 motif I; other site 1358027001452 motif II; other site 1358027001453 cell division suppressor protein YneA; Provisional; Region: PRK14125 1358027001454 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1358027001455 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1358027001456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1358027001457 active site 1358027001458 phosphorylation site [posttranslational modification] 1358027001459 intermolecular recognition site; other site 1358027001460 dimerization interface [polypeptide binding]; other site 1358027001461 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1358027001462 DNA binding site [nucleotide binding] 1358027001463 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1358027001464 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1358027001465 dimerization interface [polypeptide binding]; other site 1358027001466 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1358027001467 dimer interface [polypeptide binding]; other site 1358027001468 phosphorylation site [posttranslational modification] 1358027001469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1358027001470 ATP binding site [chemical binding]; other site 1358027001471 Mg2+ binding site [ion binding]; other site 1358027001472 G-X-G motif; other site 1358027001473 Sugar transport protein; Region: Sugar_transport; pfam06800 1358027001474 maltose O-acetyltransferase; Provisional; Region: PRK10092 1358027001475 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1358027001476 active site 1358027001477 substrate binding site [chemical binding]; other site 1358027001478 trimer interface [polypeptide binding]; other site 1358027001479 CoA binding site [chemical binding]; other site 1358027001480 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1358027001481 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1358027001482 active site 1358027001483 dimer interface [polypeptide binding]; other site 1358027001484 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1358027001485 dimer interface [polypeptide binding]; other site 1358027001486 active site 1358027001487 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1358027001488 nucleotide binding site [chemical binding]; other site 1358027001489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1358027001490 Response regulator receiver domain; Region: Response_reg; pfam00072 1358027001491 active site 1358027001492 phosphorylation site [posttranslational modification] 1358027001493 intermolecular recognition site; other site 1358027001494 dimerization interface [polypeptide binding]; other site 1358027001495 YcbB domain; Region: YcbB; pfam08664 1358027001496 ornithine carbamoyltransferase; Provisional; Region: PRK04284 1358027001497 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1358027001498 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1358027001499 carbamate kinase; Reviewed; Region: PRK12686 1358027001500 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1358027001501 putative substrate binding site [chemical binding]; other site 1358027001502 nucleotide binding site [chemical binding]; other site 1358027001503 nucleotide binding site [chemical binding]; other site 1358027001504 homodimer interface [polypeptide binding]; other site 1358027001505 EamA-like transporter family; Region: EamA; pfam00892 1358027001506 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1358027001507 EamA-like transporter family; Region: EamA; pfam00892 1358027001508 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 1358027001509 active site 1358027001510 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1358027001511 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1358027001512 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1358027001513 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1358027001514 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1358027001515 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1358027001516 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1358027001517 D5 N terminal like; Region: D5_N; smart00885 1358027001518 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1358027001519 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 1358027001520 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1358027001521 polymerase nucleotide-binding site; other site 1358027001522 DNA-binding residues [nucleotide binding]; DNA binding site 1358027001523 nucleotide binding site [chemical binding]; other site 1358027001524 primase nucleotide-binding site [nucleotide binding]; other site 1358027001525 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 1358027001526 Helix-turn-helix domain; Region: HTH_17; pfam12728 1358027001527 Helix-turn-helix domain; Region: HTH_17; pfam12728 1358027001528 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1358027001529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1358027001530 non-specific DNA binding site [nucleotide binding]; other site 1358027001531 salt bridge; other site 1358027001532 sequence-specific DNA binding site [nucleotide binding]; other site 1358027001533 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1358027001534 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1358027001535 Int/Topo IB signature motif; other site 1358027001536 MucBP domain; Region: MucBP; pfam06458 1358027001537 Beta-lactamase; Region: Beta-lactamase; pfam00144 1358027001538 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1358027001539 arginine deiminase; Provisional; Region: PRK01388 1358027001540 Arginine repressor [Transcription]; Region: ArgR; COG1438 1358027001541 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1358027001542 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1358027001543 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1358027001544 histidine-histamine antiporter; Region: his_histam_anti; TIGR04298 1358027001545 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1358027001546 catalytic triad [active] 1358027001547 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1358027001548 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1358027001549 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1358027001550 thymidine kinase; Provisional; Region: PRK04296 1358027001551 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1358027001552 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1358027001553 RF-1 domain; Region: RF-1; pfam00472 1358027001554 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1358027001555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1358027001556 S-adenosylmethionine binding site [chemical binding]; other site 1358027001557 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1358027001558 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1358027001559 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1358027001560 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1358027001561 dimer interface [polypeptide binding]; other site 1358027001562 active site 1358027001563 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1358027001564 folate binding site [chemical binding]; other site 1358027001565 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1358027001566 active site 1358027001567 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1358027001568 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1358027001569 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1358027001570 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1358027001571 YibE/F-like protein; Region: YibE_F; pfam07907 1358027001572 YibE/F-like protein; Region: YibE_F; pfam07907 1358027001573 uracil transporter; Provisional; Region: PRK10720 1358027001574 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1358027001575 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1358027001576 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1358027001577 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1358027001578 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1358027001579 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1358027001580 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1358027001581 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1358027001582 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1358027001583 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1358027001584 beta subunit interaction interface [polypeptide binding]; other site 1358027001585 Walker A motif; other site 1358027001586 ATP binding site [chemical binding]; other site 1358027001587 Walker B motif; other site 1358027001588 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1358027001589 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1358027001590 core domain interface [polypeptide binding]; other site 1358027001591 delta subunit interface [polypeptide binding]; other site 1358027001592 epsilon subunit interface [polypeptide binding]; other site 1358027001593 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1358027001594 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1358027001595 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1358027001596 alpha subunit interaction interface [polypeptide binding]; other site 1358027001597 Walker A motif; other site 1358027001598 ATP binding site [chemical binding]; other site 1358027001599 Walker B motif; other site 1358027001600 inhibitor binding site; inhibition site 1358027001601 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1358027001602 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1358027001603 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1358027001604 gamma subunit interface [polypeptide binding]; other site 1358027001605 epsilon subunit interface [polypeptide binding]; other site 1358027001606 LBP interface [polypeptide binding]; other site 1358027001607 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 1358027001608 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1358027001609 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1358027001610 hinge; other site 1358027001611 active site 1358027001612 rod shape-determining protein MreB; Provisional; Region: PRK13930 1358027001613 MreB and similar proteins; Region: MreB_like; cd10225 1358027001614 nucleotide binding site [chemical binding]; other site 1358027001615 Mg binding site [ion binding]; other site 1358027001616 putative protofilament interaction site [polypeptide binding]; other site 1358027001617 RodZ interaction site [polypeptide binding]; other site 1358027001618 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1358027001619 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1358027001620 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1358027001621 lipoyl attachment site [posttranslational modification]; other site 1358027001622 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1358027001623 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1358027001624 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1358027001625 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1358027001626 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1358027001627 non-specific DNA binding site [nucleotide binding]; other site 1358027001628 salt bridge; other site 1358027001629 sequence-specific DNA binding site [nucleotide binding]; other site 1358027001630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1358027001631 binding surface 1358027001632 TPR motif; other site 1358027001633 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1358027001634 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1358027001635 Ligand Binding Site [chemical binding]; other site 1358027001636 recombination factor protein RarA; Reviewed; Region: PRK13342 1358027001637 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027001638 Walker A motif; other site 1358027001639 ATP binding site [chemical binding]; other site 1358027001640 Walker B motif; other site 1358027001641 arginine finger; other site 1358027001642 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1358027001643 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1358027001644 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1358027001645 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1358027001646 putative active site [active] 1358027001647 putative NTP binding site [chemical binding]; other site 1358027001648 putative nucleic acid binding site [nucleotide binding]; other site 1358027001649 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1358027001650 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1358027001651 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1358027001652 active site 1358027001653 metal binding site [ion binding]; metal-binding site 1358027001654 Predicted membrane protein [Function unknown]; Region: COG2364 1358027001655 hypothetical protein; Validated; Region: PRK02101 1358027001656 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1358027001657 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1358027001658 PYR/PP interface [polypeptide binding]; other site 1358027001659 dimer interface [polypeptide binding]; other site 1358027001660 TPP binding site [chemical binding]; other site 1358027001661 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1358027001662 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1358027001663 TPP-binding site; other site 1358027001664 dimer interface [polypeptide binding]; other site 1358027001665 formyl-coenzyme A transferase; Provisional; Region: PRK05398 1358027001666 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1358027001667 glutamate racemase; Provisional; Region: PRK00865 1358027001668 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 1358027001669 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1358027001670 L-tyrosine decarboxylase; Provisional; Region: PRK13520 1358027001671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1358027001672 catalytic residue [active] 1358027001673 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1358027001674 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1358027001675 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1358027001676 RNA binding surface [nucleotide binding]; other site 1358027001677 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1358027001678 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1358027001679 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1358027001680 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1358027001681 catalytic residue [active] 1358027001682 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1358027001683 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1358027001684 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1358027001685 Ligand Binding Site [chemical binding]; other site 1358027001686 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1358027001687 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1358027001688 active site 1358027001689 HIGH motif; other site 1358027001690 nucleotide binding site [chemical binding]; other site 1358027001691 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1358027001692 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1358027001693 active site 1358027001694 KMSKS motif; other site 1358027001695 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1358027001696 tRNA binding surface [nucleotide binding]; other site 1358027001697 anticodon binding site; other site 1358027001698 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1358027001699 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1358027001700 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1358027001701 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1358027001702 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1358027001703 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1358027001704 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1358027001705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027001706 Walker A/P-loop; other site 1358027001707 ATP binding site [chemical binding]; other site 1358027001708 Q-loop/lid; other site 1358027001709 ABC transporter signature motif; other site 1358027001710 Walker B; other site 1358027001711 D-loop; other site 1358027001712 H-loop/switch region; other site 1358027001713 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1358027001714 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1358027001715 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1358027001716 Walker A/P-loop; other site 1358027001717 ATP binding site [chemical binding]; other site 1358027001718 Q-loop/lid; other site 1358027001719 ABC transporter signature motif; other site 1358027001720 Walker B; other site 1358027001721 D-loop; other site 1358027001722 H-loop/switch region; other site 1358027001723 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1358027001724 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1358027001725 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1358027001726 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1358027001727 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1358027001728 MPN+ (JAMM) motif; other site 1358027001729 Zinc-binding site [ion binding]; other site 1358027001730 rod shape-determining protein MreB; Provisional; Region: PRK13927 1358027001731 MreB and similar proteins; Region: MreB_like; cd10225 1358027001732 nucleotide binding site [chemical binding]; other site 1358027001733 Mg binding site [ion binding]; other site 1358027001734 putative protofilament interaction site [polypeptide binding]; other site 1358027001735 RodZ interaction site [polypeptide binding]; other site 1358027001736 rod shape-determining protein MreC; Provisional; Region: PRK13922 1358027001737 rod shape-determining protein MreC; Region: MreC; pfam04085 1358027001738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1358027001739 dimer interface [polypeptide binding]; other site 1358027001740 conserved gate region; other site 1358027001741 putative PBP binding loops; other site 1358027001742 ABC-ATPase subunit interface; other site 1358027001743 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1358027001744 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027001745 Walker A/P-loop; other site 1358027001746 ATP binding site [chemical binding]; other site 1358027001747 Q-loop/lid; other site 1358027001748 ABC transporter signature motif; other site 1358027001749 Walker B; other site 1358027001750 D-loop; other site 1358027001751 H-loop/switch region; other site 1358027001752 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1358027001753 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1358027001754 substrate binding pocket [chemical binding]; other site 1358027001755 membrane-bound complex binding site; other site 1358027001756 hinge residues; other site 1358027001757 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1358027001758 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1358027001759 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1358027001760 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1358027001761 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1358027001762 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1358027001763 Helix-turn-helix domain; Region: HTH_25; pfam13413 1358027001764 non-specific DNA binding site [nucleotide binding]; other site 1358027001765 salt bridge; other site 1358027001766 sequence-specific DNA binding site [nucleotide binding]; other site 1358027001767 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1358027001768 competence damage-inducible protein A; Provisional; Region: PRK00549 1358027001769 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1358027001770 putative MPT binding site; other site 1358027001771 Competence-damaged protein; Region: CinA; pfam02464 1358027001772 recombinase A; Provisional; Region: recA; PRK09354 1358027001773 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1358027001774 hexamer interface [polypeptide binding]; other site 1358027001775 Walker A motif; other site 1358027001776 ATP binding site [chemical binding]; other site 1358027001777 Walker B motif; other site 1358027001778 phosphodiesterase; Provisional; Region: PRK12704 1358027001779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1358027001780 Zn2+ binding site [ion binding]; other site 1358027001781 Mg2+ binding site [ion binding]; other site 1358027001782 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1358027001783 MutS domain I; Region: MutS_I; pfam01624 1358027001784 MutS domain II; Region: MutS_II; pfam05188 1358027001785 MutS domain III; Region: MutS_III; pfam05192 1358027001786 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1358027001787 Walker A/P-loop; other site 1358027001788 ATP binding site [chemical binding]; other site 1358027001789 Q-loop/lid; other site 1358027001790 ABC transporter signature motif; other site 1358027001791 Walker B; other site 1358027001792 D-loop; other site 1358027001793 H-loop/switch region; other site 1358027001794 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1358027001795 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1358027001796 ATP binding site [chemical binding]; other site 1358027001797 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1358027001798 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1358027001799 RuvA N terminal domain; Region: RuvA_N; pfam01330 1358027001800 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1358027001801 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1358027001802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027001803 Walker A motif; other site 1358027001804 ATP binding site [chemical binding]; other site 1358027001805 Walker B motif; other site 1358027001806 arginine finger; other site 1358027001807 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1358027001808 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1358027001809 Queuine tRNA-ribosyltransferase; Region: TGT; pfam01702 1358027001810 Preprotein translocase subunit; Region: YajC; pfam02699 1358027001811 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1358027001812 DHH family; Region: DHH; pfam01368 1358027001813 DHHA1 domain; Region: DHHA1; pfam02272 1358027001814 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1358027001815 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1358027001816 ATP binding site [chemical binding]; other site 1358027001817 Mg++ binding site [ion binding]; other site 1358027001818 motif III; other site 1358027001819 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1358027001820 nucleotide binding region [chemical binding]; other site 1358027001821 ATP-binding site [chemical binding]; other site 1358027001822 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1358027001823 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1358027001824 motif 1; other site 1358027001825 active site 1358027001826 motif 2; other site 1358027001827 motif 3; other site 1358027001828 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1358027001829 hypothetical protein; Provisional; Region: PRK05473 1358027001830 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1358027001831 hypothetical protein; Provisional; Region: PRK13678 1358027001832 Colicin V production protein; Region: Colicin_V; pfam02674 1358027001833 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1358027001834 MutS domain III; Region: MutS_III; pfam05192 1358027001835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027001836 Walker A/P-loop; other site 1358027001837 ATP binding site [chemical binding]; other site 1358027001838 Q-loop/lid; other site 1358027001839 ABC transporter signature motif; other site 1358027001840 Walker B; other site 1358027001841 D-loop; other site 1358027001842 H-loop/switch region; other site 1358027001843 Smr domain; Region: Smr; pfam01713 1358027001844 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1358027001845 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1358027001846 catalytic residues [active] 1358027001847 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1358027001848 glutamate racemase; Provisional; Region: PRK00865 1358027001849 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1358027001850 active site 1358027001851 dimerization interface [polypeptide binding]; other site 1358027001852 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1358027001853 active site 1358027001854 metal binding site [ion binding]; metal-binding site 1358027001855 homotetramer interface [polypeptide binding]; other site 1358027001856 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1358027001857 FOG: CBS domain [General function prediction only]; Region: COG0517 1358027001858 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1358027001859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1358027001860 active site 1358027001861 motif I; other site 1358027001862 motif II; other site 1358027001863 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1358027001864 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1358027001865 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1358027001866 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1358027001867 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1358027001868 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1358027001869 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1358027001870 active site 1358027001871 catabolite control protein A; Region: ccpA; TIGR01481 1358027001872 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1358027001873 DNA binding site [nucleotide binding] 1358027001874 domain linker motif; other site 1358027001875 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1358027001876 dimerization interface [polypeptide binding]; other site 1358027001877 effector binding site; other site 1358027001878 hypothetical protein; Validated; Region: PRK00110 1358027001879 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1358027001880 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1358027001881 putative active site [active] 1358027001882 putative NTP binding site [chemical binding]; other site 1358027001883 putative nucleic acid binding site [nucleotide binding]; other site 1358027001884 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1358027001885 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1358027001886 Walker A motif; other site 1358027001887 ATP binding site [chemical binding]; other site 1358027001888 Walker B motif; other site 1358027001889 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1358027001890 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1358027001891 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1358027001892 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1358027001893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1358027001894 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1358027001895 propionate/acetate kinase; Provisional; Region: PRK12379 1358027001896 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1358027001897 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1358027001898 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1358027001899 active site 1358027001900 motif I; other site 1358027001901 motif II; other site 1358027001902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1358027001903 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 1358027001904 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1358027001905 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1358027001906 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1358027001907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1358027001908 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1358027001909 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1358027001910 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1358027001911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1358027001912 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1358027001913 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1358027001914 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1358027001915 ArsC family; Region: ArsC; pfam03960 1358027001916 putative catalytic residues [active] 1358027001917 thiol/disulfide switch; other site 1358027001918 adaptor protein; Provisional; Region: PRK02315 1358027001919 Competence protein CoiA-like family; Region: CoiA; cl11541 1358027001920 Peptidase family C69; Region: Peptidase_C69; pfam03577 1358027001921 Thioredoxin; Region: Thioredoxin_5; pfam13743 1358027001922 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1358027001923 synthetase active site [active] 1358027001924 NTP binding site [chemical binding]; other site 1358027001925 metal binding site [ion binding]; metal-binding site 1358027001926 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1358027001927 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1358027001928 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1358027001929 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1358027001930 active site 1358027001931 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1358027001932 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1358027001933 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1358027001934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1358027001935 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1358027001936 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1358027001937 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1358027001938 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1358027001939 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1358027001940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1358027001941 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1358027001942 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1358027001943 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1358027001944 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1358027001945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1358027001946 S-adenosylmethionine binding site [chemical binding]; other site 1358027001947 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1358027001948 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1358027001949 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1358027001950 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1358027001951 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1358027001952 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 1358027001953 cell division protein MraZ; Reviewed; Region: PRK00326 1358027001954 MraZ protein; Region: MraZ; pfam02381 1358027001955 MraZ protein; Region: MraZ; pfam02381 1358027001956 MraW methylase family; Region: Methyltransf_5; pfam01795 1358027001957 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1358027001958 Cell division protein FtsL; Region: FtsL; cl11433 1358027001959 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1358027001960 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1358027001961 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1358027001962 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1358027001963 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1358027001964 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1358027001965 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1358027001966 Mg++ binding site [ion binding]; other site 1358027001967 putative catalytic motif [active] 1358027001968 putative substrate binding site [chemical binding]; other site 1358027001969 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1358027001970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1358027001971 S-adenosylmethionine binding site [chemical binding]; other site 1358027001972 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1358027001973 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1358027001974 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1358027001975 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1358027001976 active site 1358027001977 homodimer interface [polypeptide binding]; other site 1358027001978 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1358027001979 Cell division protein FtsQ; Region: FtsQ; pfam03799 1358027001980 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1358027001981 Cell division protein FtsA; Region: FtsA; smart00842 1358027001982 Cell division protein FtsA; Region: FtsA; pfam14450 1358027001983 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 1358027001984 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1358027001985 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1358027001986 nucleotide binding site [chemical binding]; other site 1358027001987 SulA interaction site; other site 1358027001988 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1358027001989 YGGT family; Region: YGGT; pfam02325 1358027001990 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1358027001991 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1358027001992 RNA binding surface [nucleotide binding]; other site 1358027001993 DivIVA protein; Region: DivIVA; pfam05103 1358027001994 DivIVA domain; Region: DivI1A_domain; TIGR03544 1358027001995 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1358027001996 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1358027001997 active site 1358027001998 HIGH motif; other site 1358027001999 nucleotide binding site [chemical binding]; other site 1358027002000 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1358027002001 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1358027002002 active site 1358027002003 KMSKS motif; other site 1358027002004 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1358027002005 tRNA binding surface [nucleotide binding]; other site 1358027002006 anticodon binding site; other site 1358027002007 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1358027002008 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1358027002009 DNA-binding site [nucleotide binding]; DNA binding site 1358027002010 RNA-binding motif; other site 1358027002011 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1358027002012 dimer interface [polypeptide binding]; other site 1358027002013 ADP-ribose binding site [chemical binding]; other site 1358027002014 active site 1358027002015 nudix motif; other site 1358027002016 metal binding site [ion binding]; metal-binding site 1358027002017 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1358027002018 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1358027002019 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1358027002020 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1358027002021 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1358027002022 catalytic residue [active] 1358027002023 Putative amino acid metabolism; Region: DUF1831; pfam08866 1358027002024 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1358027002025 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1358027002026 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1358027002027 catalytic core [active] 1358027002028 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1358027002029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1358027002030 binding surface 1358027002031 TPR motif; other site 1358027002032 TPR repeat; Region: TPR_11; pfam13414 1358027002033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1358027002034 binding surface 1358027002035 TPR motif; other site 1358027002036 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1358027002037 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1358027002038 AAA domain; Region: AAA_30; pfam13604 1358027002039 Family description; Region: UvrD_C_2; pfam13538 1358027002040 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1358027002041 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1358027002042 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1358027002043 active site 1358027002044 DDE superfamily endonuclease; Region: DDE_5; cl17874 1358027002045 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1358027002046 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 1358027002047 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1358027002048 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1358027002049 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1358027002050 aspartate kinase; Reviewed; Region: PRK09034 1358027002051 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1358027002052 putative catalytic residues [active] 1358027002053 putative nucleotide binding site [chemical binding]; other site 1358027002054 putative aspartate binding site [chemical binding]; other site 1358027002055 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1358027002056 allosteric regulatory residue; other site 1358027002057 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1358027002058 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1358027002059 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1358027002060 active site 1358027002061 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1358027002062 substrate binding site [chemical binding]; other site 1358027002063 catalytic residues [active] 1358027002064 dimer interface [polypeptide binding]; other site 1358027002065 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1358027002066 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1358027002067 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1358027002068 active site 1358027002069 trimer interface [polypeptide binding]; other site 1358027002070 substrate binding site [chemical binding]; other site 1358027002071 CoA binding site [chemical binding]; other site 1358027002072 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1358027002073 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1358027002074 metal binding site [ion binding]; metal-binding site 1358027002075 putative dimer interface [polypeptide binding]; other site 1358027002076 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1358027002077 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1358027002078 dimer interface [polypeptide binding]; other site 1358027002079 active site 1358027002080 catalytic residue [active] 1358027002081 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1358027002082 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1358027002083 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1358027002084 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1358027002085 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1358027002086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1358027002087 homodimer interface [polypeptide binding]; other site 1358027002088 catalytic residue [active] 1358027002089 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1358027002090 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1358027002091 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1358027002092 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1358027002093 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1358027002094 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1358027002095 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1358027002096 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1358027002097 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1358027002098 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1358027002099 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1358027002100 NlpC/P60 family; Region: NLPC_P60; pfam00877 1358027002101 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1358027002102 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1358027002103 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 1358027002104 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1358027002105 active site 1358027002106 catalytic residues [active] 1358027002107 metal binding site [ion binding]; metal-binding site 1358027002108 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1358027002109 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1358027002110 TPP-binding site [chemical binding]; other site 1358027002111 heterodimer interface [polypeptide binding]; other site 1358027002112 tetramer interface [polypeptide binding]; other site 1358027002113 phosphorylation loop region [posttranslational modification] 1358027002114 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1358027002115 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1358027002116 alpha subunit interface [polypeptide binding]; other site 1358027002117 TPP binding site [chemical binding]; other site 1358027002118 heterodimer interface [polypeptide binding]; other site 1358027002119 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1358027002120 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1358027002121 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1358027002122 E3 interaction surface; other site 1358027002123 lipoyl attachment site [posttranslational modification]; other site 1358027002124 e3 binding domain; Region: E3_binding; pfam02817 1358027002125 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1358027002126 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1358027002127 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1358027002128 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1358027002129 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1358027002130 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1358027002131 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1358027002132 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1358027002133 active site 1358027002134 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1358027002135 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1358027002136 G1 box; other site 1358027002137 putative GEF interaction site [polypeptide binding]; other site 1358027002138 GTP/Mg2+ binding site [chemical binding]; other site 1358027002139 Switch I region; other site 1358027002140 G2 box; other site 1358027002141 G3 box; other site 1358027002142 Switch II region; other site 1358027002143 G4 box; other site 1358027002144 G5 box; other site 1358027002145 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1358027002146 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1358027002147 cell division protein FtsW; Region: ftsW; TIGR02614 1358027002148 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 1358027002149 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1358027002150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1358027002151 S-adenosylmethionine binding site [chemical binding]; other site 1358027002152 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1358027002153 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1358027002154 active site 1358027002155 (T/H)XGH motif; other site 1358027002156 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1358027002157 protein binding site [polypeptide binding]; other site 1358027002158 PDZ domain; Region: PDZ_2; pfam13180 1358027002159 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1358027002160 SLBB domain; Region: SLBB; pfam10531 1358027002161 comEA protein; Region: comE; TIGR01259 1358027002162 Helix-hairpin-helix motif; Region: HHH; pfam00633 1358027002163 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1358027002164 catalytic motif [active] 1358027002165 Zn binding site [ion binding]; other site 1358027002166 Competence protein; Region: Competence; pfam03772 1358027002167 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1358027002168 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1358027002169 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1358027002170 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1358027002171 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1358027002172 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1358027002173 16S/18S rRNA binding site [nucleotide binding]; other site 1358027002174 S13e-L30e interaction site [polypeptide binding]; other site 1358027002175 25S rRNA binding site [nucleotide binding]; other site 1358027002176 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1358027002177 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1358027002178 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1358027002179 elongation factor Tu; Reviewed; Region: PRK00049 1358027002180 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1358027002181 G1 box; other site 1358027002182 GEF interaction site [polypeptide binding]; other site 1358027002183 GTP/Mg2+ binding site [chemical binding]; other site 1358027002184 Switch I region; other site 1358027002185 G2 box; other site 1358027002186 G3 box; other site 1358027002187 Switch II region; other site 1358027002188 G4 box; other site 1358027002189 G5 box; other site 1358027002190 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1358027002191 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1358027002192 Antibiotic Binding Site [chemical binding]; other site 1358027002193 trigger factor; Provisional; Region: tig; PRK01490 1358027002194 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1358027002195 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1358027002196 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1358027002197 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1358027002198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027002199 Walker A motif; other site 1358027002200 ATP binding site [chemical binding]; other site 1358027002201 Walker B motif; other site 1358027002202 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1358027002203 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1358027002204 G1 box; other site 1358027002205 GTP/Mg2+ binding site [chemical binding]; other site 1358027002206 Switch I region; other site 1358027002207 G2 box; other site 1358027002208 G3 box; other site 1358027002209 Switch II region; other site 1358027002210 G4 box; other site 1358027002211 G5 box; other site 1358027002212 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 1358027002213 putative metal binding site [ion binding]; other site 1358027002214 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1358027002215 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1358027002216 putative active site [active] 1358027002217 putative NTP binding site [chemical binding]; other site 1358027002218 putative nucleic acid binding site [nucleotide binding]; other site 1358027002219 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1358027002220 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1358027002221 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1358027002222 GIY-YIG motif/motif A; other site 1358027002223 active site 1358027002224 catalytic site [active] 1358027002225 putative DNA binding site [nucleotide binding]; other site 1358027002226 metal binding site [ion binding]; metal-binding site 1358027002227 UvrB/uvrC motif; Region: UVR; pfam02151 1358027002228 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1358027002229 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1358027002230 DNA binding site [nucleotide binding] 1358027002231 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1358027002232 GTP1/OBG; Region: GTP1_OBG; pfam01018 1358027002233 Obg GTPase; Region: Obg; cd01898 1358027002234 G1 box; other site 1358027002235 GTP/Mg2+ binding site [chemical binding]; other site 1358027002236 Switch I region; other site 1358027002237 G2 box; other site 1358027002238 G3 box; other site 1358027002239 Switch II region; other site 1358027002240 G4 box; other site 1358027002241 G5 box; other site 1358027002242 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1358027002243 ribonuclease Z; Region: RNase_Z; TIGR02651 1358027002244 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1358027002245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1358027002246 NAD(P) binding site [chemical binding]; other site 1358027002247 active site 1358027002248 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1358027002249 DHH family; Region: DHH; pfam01368 1358027002250 DHHA1 domain; Region: DHHA1; pfam02272 1358027002251 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1358027002252 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1358027002253 active site 1358027002254 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 1358027002255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1358027002256 non-specific DNA binding site [nucleotide binding]; other site 1358027002257 salt bridge; other site 1358027002258 sequence-specific DNA binding site [nucleotide binding]; other site 1358027002259 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1358027002260 non-specific DNA binding site [nucleotide binding]; other site 1358027002261 salt bridge; other site 1358027002262 sequence-specific DNA binding site [nucleotide binding]; other site 1358027002263 Domain of unknown function (DUF771); Region: DUF771; cl09962 1358027002264 Helix-turn-helix domain; Region: HTH_36; pfam13730 1358027002265 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1358027002266 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1358027002267 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1358027002268 YopX protein; Region: YopX; cl09859 1358027002269 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1358027002270 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1358027002271 catalytic residues [active] 1358027002272 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1358027002273 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1358027002274 active site 1358027002275 catalytic site [active] 1358027002276 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 1358027002277 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1358027002278 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1358027002279 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1358027002280 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1358027002281 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1358027002282 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 1358027002283 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1358027002284 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1358027002285 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1358027002286 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1358027002287 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1358027002288 Int/Topo IB signature motif; other site 1358027002289 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1358027002290 Integrase core domain; Region: rve; pfam00665 1358027002291 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1358027002292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027002293 Walker A motif; other site 1358027002294 ATP binding site [chemical binding]; other site 1358027002295 Walker B motif; other site 1358027002296 arginine finger; other site 1358027002297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1358027002298 Integrase core domain; Region: rve; pfam00665 1358027002299 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1358027002300 Helix-turn-helix domain; Region: HTH_38; pfam13936 1358027002301 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1358027002302 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1358027002303 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1358027002304 Glucan-binding protein C; Region: GbpC; pfam08363 1358027002305 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1358027002306 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 1358027002307 Toprim-like; Region: Toprim_2; pfam13155 1358027002308 TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli...; Region: TOPRIM_TopoIA; cd01028 1358027002309 active site 1358027002310 interdomain interaction site; other site 1358027002311 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 1358027002312 putative metal-binding site [ion binding]; other site 1358027002313 nucleotide binding site [chemical binding]; other site 1358027002314 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 1358027002315 domain I; other site 1358027002316 DNA binding groove [nucleotide binding] 1358027002317 phosphate binding site [ion binding]; other site 1358027002318 domain II; other site 1358027002319 domain III; other site 1358027002320 nucleotide binding site [chemical binding]; other site 1358027002321 catalytic site [active] 1358027002322 domain IV; other site 1358027002323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027002324 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1358027002325 Walker A motif; other site 1358027002326 ATP binding site [chemical binding]; other site 1358027002327 Walker B motif; other site 1358027002328 arginine finger; other site 1358027002329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027002330 Walker A motif; other site 1358027002331 ATP binding site [chemical binding]; other site 1358027002332 Walker B motif; other site 1358027002333 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1358027002334 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1358027002335 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 1358027002336 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1358027002337 RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]; Region: ROM1; COG5422 1358027002338 AAA-like domain; Region: AAA_10; pfam12846 1358027002339 CAAX protease self-immunity; Region: Abi; pfam02517 1358027002340 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1358027002341 nucleotide binding site [chemical binding]; other site 1358027002342 Fic/DOC family; Region: Fic; pfam02661 1358027002343 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 1358027002344 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1358027002345 RNA/DNA hybrid binding site [nucleotide binding]; other site 1358027002346 active site 1358027002347 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1358027002348 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1358027002349 dimer interface [polypeptide binding]; other site 1358027002350 active site 1358027002351 LexA repressor; Validated; Region: PRK00215 1358027002352 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1358027002353 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1358027002354 Catalytic site [active] 1358027002355 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1358027002356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1358027002357 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1358027002358 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1358027002359 putative acyl-acceptor binding pocket; other site 1358027002360 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1358027002361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1358027002362 S-adenosylmethionine binding site [chemical binding]; other site 1358027002363 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1358027002364 GIY-YIG motif/motif A; other site 1358027002365 putative active site [active] 1358027002366 putative metal binding site [ion binding]; other site 1358027002367 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1358027002368 D-lactate dehydrogenase; Validated; Region: PRK08605 1358027002369 homodimer interface [polypeptide binding]; other site 1358027002370 ligand binding site [chemical binding]; other site 1358027002371 NAD binding site [chemical binding]; other site 1358027002372 catalytic site [active] 1358027002373 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1358027002374 rRNA interaction site [nucleotide binding]; other site 1358027002375 S8 interaction site; other site 1358027002376 putative laminin-1 binding site; other site 1358027002377 elongation factor Ts; Provisional; Region: tsf; PRK09377 1358027002378 UBA/TS-N domain; Region: UBA; pfam00627 1358027002379 Elongation factor TS; Region: EF_TS; pfam00889 1358027002380 Elongation factor TS; Region: EF_TS; pfam00889 1358027002381 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1358027002382 putative nucleotide binding site [chemical binding]; other site 1358027002383 uridine monophosphate binding site [chemical binding]; other site 1358027002384 homohexameric interface [polypeptide binding]; other site 1358027002385 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1358027002386 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1358027002387 hinge region; other site 1358027002388 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1358027002389 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1358027002390 catalytic residue [active] 1358027002391 putative FPP diphosphate binding site; other site 1358027002392 putative FPP binding hydrophobic cleft; other site 1358027002393 dimer interface [polypeptide binding]; other site 1358027002394 putative IPP diphosphate binding site; other site 1358027002395 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1358027002396 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1358027002397 RIP metalloprotease RseP; Region: TIGR00054 1358027002398 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1358027002399 active site 1358027002400 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1358027002401 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1358027002402 protein binding site [polypeptide binding]; other site 1358027002403 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1358027002404 putative substrate binding region [chemical binding]; other site 1358027002405 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1358027002406 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1358027002407 dimer interface [polypeptide binding]; other site 1358027002408 motif 1; other site 1358027002409 active site 1358027002410 motif 2; other site 1358027002411 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1358027002412 putative deacylase active site [active] 1358027002413 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1358027002414 active site 1358027002415 motif 3; other site 1358027002416 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1358027002417 anticodon binding site; other site 1358027002418 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1358027002419 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1358027002420 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1358027002421 generic binding surface II; other site 1358027002422 generic binding surface I; other site 1358027002423 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1358027002424 active site 1358027002425 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1358027002426 active site 1358027002427 catalytic site [active] 1358027002428 substrate binding site [chemical binding]; other site 1358027002429 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1358027002430 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1358027002431 Sm and related proteins; Region: Sm_like; cl00259 1358027002432 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1358027002433 putative oligomer interface [polypeptide binding]; other site 1358027002434 putative RNA binding site [nucleotide binding]; other site 1358027002435 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1358027002436 NusA N-terminal domain; Region: NusA_N; pfam08529 1358027002437 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1358027002438 RNA binding site [nucleotide binding]; other site 1358027002439 homodimer interface [polypeptide binding]; other site 1358027002440 NusA-like KH domain; Region: KH_5; pfam13184 1358027002441 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1358027002442 G-X-X-G motif; other site 1358027002443 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1358027002444 putative RNA binding cleft [nucleotide binding]; other site 1358027002445 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1358027002446 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1358027002447 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1358027002448 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1358027002449 RNA binding site [nucleotide binding]; other site 1358027002450 active site 1358027002451 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1358027002452 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1358027002453 active site 1358027002454 Riboflavin kinase; Region: Flavokinase; smart00904 1358027002455 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1358027002456 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1358027002457 GrpE; Region: GrpE; pfam01025 1358027002458 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1358027002459 dimer interface [polypeptide binding]; other site 1358027002460 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1358027002461 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1358027002462 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1358027002463 nucleotide binding site [chemical binding]; other site 1358027002464 NEF interaction site [polypeptide binding]; other site 1358027002465 SBD interface [polypeptide binding]; other site 1358027002466 chaperone protein DnaJ; Provisional; Region: PRK14276 1358027002467 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1358027002468 HSP70 interaction site [polypeptide binding]; other site 1358027002469 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1358027002470 substrate binding site [polypeptide binding]; other site 1358027002471 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1358027002472 Zn binding sites [ion binding]; other site 1358027002473 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1358027002474 dimer interface [polypeptide binding]; other site 1358027002475 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1358027002476 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1358027002477 GTP-binding protein LepA; Provisional; Region: PRK05433 1358027002478 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1358027002479 G1 box; other site 1358027002480 putative GEF interaction site [polypeptide binding]; other site 1358027002481 GTP/Mg2+ binding site [chemical binding]; other site 1358027002482 Switch I region; other site 1358027002483 G2 box; other site 1358027002484 G3 box; other site 1358027002485 Switch II region; other site 1358027002486 G4 box; other site 1358027002487 G5 box; other site 1358027002488 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1358027002489 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1358027002490 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1358027002491 Peptidase family C69; Region: Peptidase_C69; pfam03577 1358027002492 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1358027002493 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1358027002494 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1358027002495 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1358027002496 NAD binding site [chemical binding]; other site 1358027002497 dimer interface [polypeptide binding]; other site 1358027002498 substrate binding site [chemical binding]; other site 1358027002499 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 1358027002500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1358027002501 S-adenosylmethionine binding site [chemical binding]; other site 1358027002502 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1358027002503 RNA methyltransferase, RsmE family; Region: TIGR00046 1358027002504 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1358027002505 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1358027002506 Zn2+ binding site [ion binding]; other site 1358027002507 Mg2+ binding site [ion binding]; other site 1358027002508 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1358027002509 synthetase active site [active] 1358027002510 NTP binding site [chemical binding]; other site 1358027002511 metal binding site [ion binding]; metal-binding site 1358027002512 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1358027002513 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1358027002514 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1358027002515 putative active site [active] 1358027002516 dimerization interface [polypeptide binding]; other site 1358027002517 putative tRNAtyr binding site [nucleotide binding]; other site 1358027002518 Phosphotransferase enzyme family; Region: APH; pfam01636 1358027002519 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1358027002520 active site 1358027002521 substrate binding site [chemical binding]; other site 1358027002522 ATP binding site [chemical binding]; other site 1358027002523 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1358027002524 substrate binding site [chemical binding]; other site 1358027002525 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1358027002526 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1358027002527 dimer interface [polypeptide binding]; other site 1358027002528 anticodon binding site; other site 1358027002529 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1358027002530 homodimer interface [polypeptide binding]; other site 1358027002531 motif 1; other site 1358027002532 active site 1358027002533 motif 2; other site 1358027002534 GAD domain; Region: GAD; pfam02938 1358027002535 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1358027002536 active site 1358027002537 motif 3; other site 1358027002538 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1358027002539 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1358027002540 substrate binding pocket [chemical binding]; other site 1358027002541 membrane-bound complex binding site; other site 1358027002542 hinge residues; other site 1358027002543 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1358027002544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1358027002545 dimer interface [polypeptide binding]; other site 1358027002546 conserved gate region; other site 1358027002547 putative PBP binding loops; other site 1358027002548 ABC-ATPase subunit interface; other site 1358027002549 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1358027002550 Yqey-like protein; Region: YqeY; pfam09424 1358027002551 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1358027002552 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1358027002553 active site 1358027002554 argininosuccinate synthase; Provisional; Region: PRK13820 1358027002555 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1358027002556 ANP binding site [chemical binding]; other site 1358027002557 Substrate Binding Site II [chemical binding]; other site 1358027002558 Substrate Binding Site I [chemical binding]; other site 1358027002559 argininosuccinate lyase; Provisional; Region: PRK00855 1358027002560 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1358027002561 active sites [active] 1358027002562 tetramer interface [polypeptide binding]; other site 1358027002563 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1358027002564 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1358027002565 putative active site [active] 1358027002566 putative NTP binding site [chemical binding]; other site 1358027002567 putative nucleic acid binding site [nucleotide binding]; other site 1358027002568 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1358027002569 Integrase core domain; Region: rve; pfam00665 1358027002570 Integrase core domain; Region: rve_3; pfam13683 1358027002571 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1358027002572 Helix-turn-helix domain; Region: HTH_28; pfam13518 1358027002573 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1358027002574 PhoH-like protein; Region: PhoH; pfam02562 1358027002575 metal-binding heat shock protein; Provisional; Region: PRK00016 1358027002576 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1358027002577 GTPase Era; Reviewed; Region: era; PRK00089 1358027002578 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1358027002579 G1 box; other site 1358027002580 GTP/Mg2+ binding site [chemical binding]; other site 1358027002581 Switch I region; other site 1358027002582 G2 box; other site 1358027002583 Switch II region; other site 1358027002584 G3 box; other site 1358027002585 G4 box; other site 1358027002586 G5 box; other site 1358027002587 Recombination protein O N terminal; Region: RecO_N; pfam11967 1358027002588 DNA repair protein RecO; Region: reco; TIGR00613 1358027002589 Recombination protein O C terminal; Region: RecO_C; pfam02565 1358027002590 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1358027002591 dimer interface [polypeptide binding]; other site 1358027002592 motif 1; other site 1358027002593 active site 1358027002594 motif 2; other site 1358027002595 motif 3; other site 1358027002596 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1358027002597 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1358027002598 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1358027002599 DNA primase; Validated; Region: dnaG; PRK05667 1358027002600 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1358027002601 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1358027002602 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1358027002603 active site 1358027002604 metal binding site [ion binding]; metal-binding site 1358027002605 interdomain interaction site; other site 1358027002606 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1358027002607 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1358027002608 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1358027002609 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1358027002610 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1358027002611 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1358027002612 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1358027002613 DNA binding residues [nucleotide binding] 1358027002614 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1358027002615 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1358027002616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1358027002617 homodimer interface [polypeptide binding]; other site 1358027002618 catalytic residue [active] 1358027002619 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1358027002620 Family of unknown function (DUF633); Region: DUF633; pfam04816 1358027002621 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1358027002622 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1358027002623 peptidase T; Region: peptidase-T; TIGR01882 1358027002624 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1358027002625 metal binding site [ion binding]; metal-binding site 1358027002626 dimer interface [polypeptide binding]; other site 1358027002627 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1358027002628 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1358027002629 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1358027002630 active site 1358027002631 PHP Thumb interface [polypeptide binding]; other site 1358027002632 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1358027002633 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1358027002634 generic binding surface II; other site 1358027002635 generic binding surface I; other site 1358027002636 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1358027002637 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1358027002638 domain interfaces; other site 1358027002639 active site 1358027002640 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1358027002641 S1 domain; Region: S1_2; pfam13509 1358027002642 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1358027002643 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1358027002644 active site 1358027002645 DNA binding site [nucleotide binding] 1358027002646 Int/Topo IB signature motif; other site 1358027002647 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1358027002648 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1358027002649 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1358027002650 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1358027002651 RNA binding surface [nucleotide binding]; other site 1358027002652 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1358027002653 active site 1358027002654 Predicted membrane protein [Function unknown]; Region: COG3601 1358027002655 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1358027002656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1358027002657 ATP-dependent DNA helicase, RecQ family; Region: recQ_fam; TIGR00614 1358027002658 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1358027002659 ATP binding site [chemical binding]; other site 1358027002660 putative Mg++ binding site [ion binding]; other site 1358027002661 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1358027002662 nucleotide binding region [chemical binding]; other site 1358027002663 ATP-binding site [chemical binding]; other site 1358027002664 cytidylate kinase; Provisional; Region: cmk; PRK00023 1358027002665 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1358027002666 CMP-binding site; other site 1358027002667 The sites determining sugar specificity; other site 1358027002668 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1358027002669 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1358027002670 RNA binding site [nucleotide binding]; other site 1358027002671 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1358027002672 RNA binding site [nucleotide binding]; other site 1358027002673 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1358027002674 RNA binding site [nucleotide binding]; other site 1358027002675 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1358027002676 RNA binding site [nucleotide binding]; other site 1358027002677 GTP-binding protein Der; Reviewed; Region: PRK00093 1358027002678 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1358027002679 G1 box; other site 1358027002680 GTP/Mg2+ binding site [chemical binding]; other site 1358027002681 Switch I region; other site 1358027002682 G2 box; other site 1358027002683 Switch II region; other site 1358027002684 G3 box; other site 1358027002685 G4 box; other site 1358027002686 G5 box; other site 1358027002687 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1358027002688 G1 box; other site 1358027002689 GTP/Mg2+ binding site [chemical binding]; other site 1358027002690 Switch I region; other site 1358027002691 G2 box; other site 1358027002692 G3 box; other site 1358027002693 Switch II region; other site 1358027002694 G4 box; other site 1358027002695 G5 box; other site 1358027002696 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1358027002697 IHF - DNA interface [nucleotide binding]; other site 1358027002698 IHF dimer interface [polypeptide binding]; other site 1358027002699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1358027002700 binding surface 1358027002701 TPR motif; other site 1358027002702 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1358027002703 TPR motif; other site 1358027002704 binding surface 1358027002705 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1358027002706 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1358027002707 TPR motif; other site 1358027002708 binding surface 1358027002709 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1358027002710 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1358027002711 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1358027002712 active site 1358027002713 NTP binding site [chemical binding]; other site 1358027002714 metal binding triad [ion binding]; metal-binding site 1358027002715 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1358027002716 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1358027002717 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1358027002718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027002719 Walker A/P-loop; other site 1358027002720 ATP binding site [chemical binding]; other site 1358027002721 Q-loop/lid; other site 1358027002722 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1358027002723 ABC transporter signature motif; other site 1358027002724 Walker B; other site 1358027002725 D-loop; other site 1358027002726 ABC transporter; Region: ABC_tran_2; pfam12848 1358027002727 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1358027002728 thymidylate synthase; Region: thym_sym; TIGR03284 1358027002729 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1358027002730 dimerization interface [polypeptide binding]; other site 1358027002731 active site 1358027002732 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1358027002733 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1358027002734 folate binding site [chemical binding]; other site 1358027002735 NADP+ binding site [chemical binding]; other site 1358027002736 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1358027002737 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1358027002738 EDD domain protein, DegV family; Region: DegV; TIGR00762 1358027002739 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1358027002740 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1358027002741 active site 1358027002742 catalytic triad [active] 1358027002743 oxyanion hole [active] 1358027002744 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1358027002745 hypothetical protein; Provisional; Region: PRK13672 1358027002746 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 1358027002747 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1358027002748 GTP/Mg2+ binding site [chemical binding]; other site 1358027002749 G4 box; other site 1358027002750 G5 box; other site 1358027002751 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1358027002752 G1 box; other site 1358027002753 G1 box; other site 1358027002754 GTP/Mg2+ binding site [chemical binding]; other site 1358027002755 Switch I region; other site 1358027002756 G2 box; other site 1358027002757 G2 box; other site 1358027002758 G3 box; other site 1358027002759 G3 box; other site 1358027002760 Switch II region; other site 1358027002761 Switch II region; other site 1358027002762 G4 box; other site 1358027002763 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1358027002764 RNA/DNA hybrid binding site [nucleotide binding]; other site 1358027002765 active site 1358027002766 DNA protecting protein DprA; Region: dprA; TIGR00732 1358027002767 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1358027002768 DNA topoisomerase I; Validated; Region: PRK05582 1358027002769 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1358027002770 active site 1358027002771 interdomain interaction site; other site 1358027002772 putative metal-binding site [ion binding]; other site 1358027002773 nucleotide binding site [chemical binding]; other site 1358027002774 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1358027002775 domain I; other site 1358027002776 DNA binding groove [nucleotide binding] 1358027002777 phosphate binding site [ion binding]; other site 1358027002778 domain II; other site 1358027002779 domain III; other site 1358027002780 nucleotide binding site [chemical binding]; other site 1358027002781 catalytic site [active] 1358027002782 domain IV; other site 1358027002783 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1358027002784 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1358027002785 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1358027002786 active site 1358027002787 catalytic residues [active] 1358027002788 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1358027002789 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1358027002790 putative active site [active] 1358027002791 putative NTP binding site [chemical binding]; other site 1358027002792 putative nucleic acid binding site [nucleotide binding]; other site 1358027002793 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1358027002794 membrane protein; Provisional; Region: PRK14392 1358027002795 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1358027002796 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1358027002797 CAP-like domain; other site 1358027002798 active site 1358027002799 primary dimer interface [polypeptide binding]; other site 1358027002800 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1358027002801 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1358027002802 nudix motif; other site 1358027002803 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1358027002804 DHH family; Region: DHH; pfam01368 1358027002805 DHHA2 domain; Region: DHHA2; pfam02833 1358027002806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1358027002807 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1358027002808 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1358027002809 Coenzyme A binding pocket [chemical binding]; other site 1358027002810 Asp23 family; Region: Asp23; pfam03780 1358027002811 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1358027002812 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1358027002813 N- and C-terminal domain interface [polypeptide binding]; other site 1358027002814 active site 1358027002815 catalytic site [active] 1358027002816 metal binding site [ion binding]; metal-binding site 1358027002817 carbohydrate binding site [chemical binding]; other site 1358027002818 ATP binding site [chemical binding]; other site 1358027002819 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1358027002820 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1358027002821 DNA binding site [nucleotide binding] 1358027002822 domain linker motif; other site 1358027002823 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1358027002824 putative dimerization interface [polypeptide binding]; other site 1358027002825 putative ligand binding site [chemical binding]; other site 1358027002826 GntP family permease; Region: GntP_permease; pfam02447 1358027002827 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1358027002828 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1358027002829 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1358027002830 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1358027002831 N- and C-terminal domain interface [polypeptide binding]; other site 1358027002832 active site 1358027002833 catalytic site [active] 1358027002834 metal binding site [ion binding]; metal-binding site 1358027002835 carbohydrate binding site [chemical binding]; other site 1358027002836 ATP binding site [chemical binding]; other site 1358027002837 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1358027002838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1358027002839 Coenzyme A binding pocket [chemical binding]; other site 1358027002840 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1358027002841 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1358027002842 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1358027002843 Helix-turn-helix domain; Region: HTH_28; pfam13518 1358027002844 Integrase core domain; Region: rve; pfam00665 1358027002845 Integrase core domain; Region: rve_3; pfam13683 1358027002846 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1358027002847 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1358027002848 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1358027002849 ATP binding site [chemical binding]; other site 1358027002850 putative Mg++ binding site [ion binding]; other site 1358027002851 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 1358027002852 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1358027002853 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1358027002854 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1358027002855 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1358027002856 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1358027002857 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1358027002858 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1358027002859 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1358027002860 non-specific DNA binding site [nucleotide binding]; other site 1358027002861 salt bridge; other site 1358027002862 sequence-specific DNA binding site [nucleotide binding]; other site 1358027002863 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1358027002864 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1358027002865 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1358027002866 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1358027002867 Int/Topo IB signature motif; other site 1358027002868 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1358027002869 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1358027002870 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1358027002871 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1358027002872 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1358027002873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1358027002874 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1358027002875 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1358027002876 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1358027002877 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1358027002878 Restriction endonuclease; Region: Mrr_cat; pfam04471 1358027002879 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1358027002880 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1358027002881 Restriction endonuclease; Region: Mrr_cat; pfam04471 1358027002882 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 1358027002883 PLD-like domain; Region: PLDc_2; pfam13091 1358027002884 homodimer interface [polypeptide binding]; other site 1358027002885 putative active site [active] 1358027002886 catalytic site [active] 1358027002887 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1358027002888 active site 1358027002889 tetramer interface [polypeptide binding]; other site 1358027002890 Ion transport protein; Region: Ion_trans; pfam00520 1358027002891 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1358027002892 Domain of unknown function (DUF373); Region: DUF373; cl12079 1358027002893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027002894 D-galactonate transporter; Region: 2A0114; TIGR00893 1358027002895 putative substrate translocation pore; other site 1358027002896 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1358027002897 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1358027002898 DNA binding residues [nucleotide binding] 1358027002899 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1358027002900 CoenzymeA binding site [chemical binding]; other site 1358027002901 subunit interaction site [polypeptide binding]; other site 1358027002902 PHB binding site; other site 1358027002903 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1358027002904 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1358027002905 substrate binding site [chemical binding]; other site 1358027002906 oxyanion hole (OAH) forming residues; other site 1358027002907 trimer interface [polypeptide binding]; other site 1358027002908 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1358027002909 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1358027002910 acyl-activating enzyme (AAE) consensus motif; other site 1358027002911 putative AMP binding site [chemical binding]; other site 1358027002912 putative active site [active] 1358027002913 putative CoA binding site [chemical binding]; other site 1358027002914 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1358027002915 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1358027002916 G1 box; other site 1358027002917 GTP/Mg2+ binding site [chemical binding]; other site 1358027002918 Switch I region; other site 1358027002919 G2 box; other site 1358027002920 G3 box; other site 1358027002921 Switch II region; other site 1358027002922 G4 box; other site 1358027002923 G5 box; other site 1358027002924 Nucleoside recognition; Region: Gate; pfam07670 1358027002925 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1358027002926 Nucleoside recognition; Region: Gate; pfam07670 1358027002927 FeoA domain; Region: FeoA; pfam04023 1358027002928 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1358027002929 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1358027002930 Walker A/P-loop; other site 1358027002931 ATP binding site [chemical binding]; other site 1358027002932 Q-loop/lid; other site 1358027002933 ABC transporter signature motif; other site 1358027002934 Walker B; other site 1358027002935 D-loop; other site 1358027002936 H-loop/switch region; other site 1358027002937 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1358027002938 FeS assembly protein SufD; Region: sufD; TIGR01981 1358027002939 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1358027002940 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1358027002941 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1358027002942 catalytic residue [active] 1358027002943 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1358027002944 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1358027002945 trimerization site [polypeptide binding]; other site 1358027002946 active site 1358027002947 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1358027002948 FeS assembly protein SufB; Region: sufB; TIGR01980 1358027002949 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1358027002950 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1358027002951 non-specific DNA binding site [nucleotide binding]; other site 1358027002952 salt bridge; other site 1358027002953 sequence-specific DNA binding site [nucleotide binding]; other site 1358027002954 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1358027002955 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1358027002956 putative active site [active] 1358027002957 putative NTP binding site [chemical binding]; other site 1358027002958 putative nucleic acid binding site [nucleotide binding]; other site 1358027002959 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1358027002960 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1358027002961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1358027002962 active site 1358027002963 phosphorylation site [posttranslational modification] 1358027002964 intermolecular recognition site; other site 1358027002965 dimerization interface [polypeptide binding]; other site 1358027002966 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1358027002967 DNA binding residues [nucleotide binding] 1358027002968 dimerization interface [polypeptide binding]; other site 1358027002969 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 1358027002970 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1358027002971 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1358027002972 active site 1358027002973 motif I; other site 1358027002974 motif II; other site 1358027002975 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1358027002976 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1358027002977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1358027002978 S-adenosylmethionine binding site [chemical binding]; other site 1358027002979 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1358027002980 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1358027002981 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1358027002982 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1358027002983 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1358027002984 GAF domain; Region: GAF_3; pfam13492 1358027002985 Histidine kinase; Region: His_kinase; pfam06580 1358027002986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1358027002987 ATP binding site [chemical binding]; other site 1358027002988 Mg2+ binding site [ion binding]; other site 1358027002989 G-X-G motif; other site 1358027002990 two-component response regulator; Provisional; Region: PRK14084 1358027002991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1358027002992 active site 1358027002993 phosphorylation site [posttranslational modification] 1358027002994 intermolecular recognition site; other site 1358027002995 dimerization interface [polypeptide binding]; other site 1358027002996 LytTr DNA-binding domain; Region: LytTR; smart00850 1358027002997 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1358027002998 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1358027002999 putative active site [active] 1358027003000 putative NTP binding site [chemical binding]; other site 1358027003001 putative nucleic acid binding site [nucleotide binding]; other site 1358027003002 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1358027003003 LrgA family; Region: LrgA; cl00608 1358027003004 LrgB-like family; Region: LrgB; cl00596 1358027003005 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1358027003006 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1358027003007 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1358027003008 NAD binding site [chemical binding]; other site 1358027003009 dimer interface [polypeptide binding]; other site 1358027003010 substrate binding site [chemical binding]; other site 1358027003011 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1358027003012 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1358027003013 nucleotide binding site [chemical binding]; other site 1358027003014 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1358027003015 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1358027003016 DNA binding site [nucleotide binding] 1358027003017 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1358027003018 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1358027003019 Melibiase; Region: Melibiase; pfam02065 1358027003020 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 1358027003021 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1358027003022 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1358027003023 homotetramer interface [polypeptide binding]; other site 1358027003024 FMN binding site [chemical binding]; other site 1358027003025 homodimer contacts [polypeptide binding]; other site 1358027003026 putative active site [active] 1358027003027 putative substrate binding site [chemical binding]; other site 1358027003028 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1358027003029 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1358027003030 diphosphomevalonate decarboxylase; Region: PLN02407 1358027003031 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1358027003032 diphosphomevalonate decarboxylase; Region: PLN02407 1358027003033 mevalonate kinase; Region: mevalon_kin; TIGR00549 1358027003034 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1358027003035 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1358027003036 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1358027003037 active site 1358027003038 catalytic site [active] 1358027003039 substrate binding site [chemical binding]; other site 1358027003040 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1358027003041 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1358027003042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1358027003043 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1358027003044 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1358027003045 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1358027003046 EamA-like transporter family; Region: EamA; pfam00892 1358027003047 EamA-like transporter family; Region: EamA; pfam00892 1358027003048 Transglycosylase; Region: Transgly; pfam00912 1358027003049 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1358027003050 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1358027003051 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1358027003052 hypothetical protein; Provisional; Region: PRK13660 1358027003053 cell division protein GpsB; Provisional; Region: PRK14127 1358027003054 DivIVA domain; Region: DivI1A_domain; TIGR03544 1358027003055 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 1358027003056 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1358027003057 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1358027003058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1358027003059 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1358027003060 RNA/DNA hybrid binding site [nucleotide binding]; other site 1358027003061 active site 1358027003062 lipoprotein signal peptidase; Provisional; Region: PRK14797 1358027003063 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1358027003064 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1358027003065 RNA binding surface [nucleotide binding]; other site 1358027003066 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1358027003067 active site 1358027003068 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1358027003069 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1358027003070 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1358027003071 catalytic site [active] 1358027003072 subunit interface [polypeptide binding]; other site 1358027003073 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1358027003074 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 1358027003075 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1358027003076 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1358027003077 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 1358027003078 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1358027003079 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1358027003080 EDD domain protein, DegV family; Region: DegV; TIGR00762 1358027003081 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1358027003082 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1358027003083 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1358027003084 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1358027003085 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1358027003086 Ligand binding site; other site 1358027003087 metal-binding site 1358027003088 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1358027003089 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1358027003090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1358027003091 Coenzyme A binding pocket [chemical binding]; other site 1358027003092 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1358027003093 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1358027003094 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1358027003095 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1358027003096 putative active site [active] 1358027003097 putative NTP binding site [chemical binding]; other site 1358027003098 putative nucleic acid binding site [nucleotide binding]; other site 1358027003099 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1358027003100 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1358027003101 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1358027003102 active site 1358027003103 catalytic tetrad [active] 1358027003104 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1358027003105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1358027003106 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1358027003107 dimerization interface [polypeptide binding]; other site 1358027003108 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1358027003109 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1358027003110 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1358027003111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027003112 putative substrate translocation pore; other site 1358027003113 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1358027003114 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1358027003115 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1358027003116 Domain of unknown function DUF21; Region: DUF21; pfam01595 1358027003117 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1358027003118 Transporter associated domain; Region: CorC_HlyC; smart01091 1358027003119 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1358027003120 ABC1 family; Region: ABC1; cl17513 1358027003121 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1358027003122 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1358027003123 putative active site [active] 1358027003124 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1358027003125 dimer interface [polypeptide binding]; other site 1358027003126 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1358027003127 metal binding site [ion binding]; metal-binding site 1358027003128 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1358027003129 CrcB-like protein; Region: CRCB; pfam02537 1358027003130 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027003131 Walker A/P-loop; other site 1358027003132 ATP binding site [chemical binding]; other site 1358027003133 Q-loop/lid; other site 1358027003134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027003135 ABC transporter signature motif; other site 1358027003136 Walker B; other site 1358027003137 D-loop; other site 1358027003138 H-loop/switch region; other site 1358027003139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027003140 AAA domain; Region: AAA_21; pfam13304 1358027003141 Walker A/P-loop; other site 1358027003142 ATP binding site [chemical binding]; other site 1358027003143 Q-loop/lid; other site 1358027003144 ABC transporter signature motif; other site 1358027003145 Walker B; other site 1358027003146 D-loop; other site 1358027003147 H-loop/switch region; other site 1358027003148 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1358027003149 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1358027003150 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1358027003151 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 1358027003152 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1358027003153 TPP-binding site; other site 1358027003154 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1358027003155 PYR/PP interface [polypeptide binding]; other site 1358027003156 dimer interface [polypeptide binding]; other site 1358027003157 TPP binding site [chemical binding]; other site 1358027003158 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1358027003159 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1358027003160 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1358027003161 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1358027003162 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1358027003163 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1358027003164 putative active site [active] 1358027003165 catalytic site [active] 1358027003166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1358027003167 Walker A motif; other site 1358027003168 ATP binding site [chemical binding]; other site 1358027003169 Walker B motif; other site 1358027003170 arginine finger; other site 1358027003171 Protein of unknown function (DUF454); Region: DUF454; cl01063 1358027003172 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 1358027003173 Predicted membrane protein [Function unknown]; Region: COG2323 1358027003174 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1358027003175 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1358027003176 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1358027003177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1358027003178 active site 1358027003179 motif I; other site 1358027003180 motif II; other site 1358027003181 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1358027003182 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1358027003183 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1358027003184 DNA binding site [nucleotide binding] 1358027003185 active site 1358027003186 Int/Topo IB signature motif; other site 1358027003187 Abortive infection C-terminus; Region: Abi_C; pfam14355 1358027003188 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1358027003189 salt bridge; other site 1358027003190 non-specific DNA binding site [nucleotide binding]; other site 1358027003191 sequence-specific DNA binding site [nucleotide binding]; other site 1358027003192 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1358027003193 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1358027003194 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1358027003195 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1358027003196 catalytic residues [active] 1358027003197 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1358027003198 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1358027003199 putative active site [active] 1358027003200 putative NTP binding site [chemical binding]; other site 1358027003201 putative nucleic acid binding site [nucleotide binding]; other site 1358027003202 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1358027003203 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 1358027003204 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1358027003205 NAD binding site [chemical binding]; other site 1358027003206 homotetramer interface [polypeptide binding]; other site 1358027003207 homodimer interface [polypeptide binding]; other site 1358027003208 substrate binding site [chemical binding]; other site 1358027003209 active site 1358027003210 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 1358027003211 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1358027003212 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1358027003213 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1358027003214 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1358027003215 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1358027003216 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1358027003217 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1358027003218 active site 1358027003219 DNA binding site [nucleotide binding] 1358027003220 Int/Topo IB signature motif; other site 1358027003221 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236 1358027003222 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1358027003223 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1358027003224 active site 1358027003225 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1358027003226 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1358027003227 active site 1358027003228 nucleophile elbow; other site 1358027003229 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1358027003230 DNA binding site [nucleotide binding] 1358027003231 Int/Topo IB signature motif; other site 1358027003232 active site 1358027003233 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1358027003234 EamA-like transporter family; Region: EamA; pfam00892 1358027003235 EamA-like transporter family; Region: EamA; pfam00892 1358027003236 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1358027003237 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1358027003238 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1358027003239 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1358027003240 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1358027003241 [4Fe-4S] binding site [ion binding]; other site 1358027003242 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1358027003243 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1358027003244 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1358027003245 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1358027003246 molybdopterin cofactor binding site; other site 1358027003247 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1358027003248 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1358027003249 ATP binding site [chemical binding]; other site 1358027003250 substrate interface [chemical binding]; other site 1358027003251 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1358027003252 MPT binding site; other site 1358027003253 trimer interface [polypeptide binding]; other site 1358027003254 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1358027003255 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1358027003256 dimer interface [polypeptide binding]; other site 1358027003257 putative functional site; other site 1358027003258 putative MPT binding site; other site 1358027003259 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1358027003260 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1358027003261 GTP binding site; other site 1358027003262 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1358027003263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1358027003264 ATP binding site [chemical binding]; other site 1358027003265 Mg2+ binding site [ion binding]; other site 1358027003266 G-X-G motif; other site 1358027003267 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1358027003268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1358027003269 active site 1358027003270 phosphorylation site [posttranslational modification] 1358027003271 intermolecular recognition site; other site 1358027003272 dimerization interface [polypeptide binding]; other site 1358027003273 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1358027003274 DNA binding residues [nucleotide binding] 1358027003275 dimerization interface [polypeptide binding]; other site 1358027003276 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1358027003277 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1358027003278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027003279 putative substrate translocation pore; other site 1358027003280 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1358027003281 MoaE interaction surface [polypeptide binding]; other site 1358027003282 MoeB interaction surface [polypeptide binding]; other site 1358027003283 thiocarboxylated glycine; other site 1358027003284 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1358027003285 MoaE homodimer interface [polypeptide binding]; other site 1358027003286 MoaD interaction [polypeptide binding]; other site 1358027003287 active site residues [active] 1358027003288 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1358027003289 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1358027003290 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1358027003291 ABC-ATPase subunit interface; other site 1358027003292 dimer interface [polypeptide binding]; other site 1358027003293 putative PBP binding regions; other site 1358027003294 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1358027003295 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1358027003296 Walker A/P-loop; other site 1358027003297 ATP binding site [chemical binding]; other site 1358027003298 Q-loop/lid; other site 1358027003299 ABC transporter signature motif; other site 1358027003300 Walker B; other site 1358027003301 D-loop; other site 1358027003302 H-loop/switch region; other site 1358027003303 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1358027003304 putative ligand binding residues [chemical binding]; other site 1358027003305 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1358027003306 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1358027003307 substrate binding site [chemical binding]; other site 1358027003308 multimerization interface [polypeptide binding]; other site 1358027003309 ATP binding site [chemical binding]; other site 1358027003310 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1358027003311 dimer interface [polypeptide binding]; other site 1358027003312 substrate binding site [chemical binding]; other site 1358027003313 ATP binding site [chemical binding]; other site 1358027003314 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1358027003315 thiamine phosphate binding site [chemical binding]; other site 1358027003316 active site 1358027003317 pyrophosphate binding site [ion binding]; other site 1358027003318 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1358027003319 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1358027003320 putative ion selectivity filter; other site 1358027003321 putative pore gating glutamate residue; other site 1358027003322 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1358027003323 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1358027003324 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 1358027003325 trimer interface [polypeptide binding]; other site 1358027003326 active site 1358027003327 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 1358027003328 catalytic site [active] 1358027003329 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1358027003330 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1358027003331 active site 1358027003332 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1358027003333 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1358027003334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1358027003335 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1358027003336 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1358027003337 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1358027003338 Bacterial lipoprotein; Region: DUF3642; pfam12182 1358027003339 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1358027003340 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1358027003341 active site 1358027003342 trimer interface [polypeptide binding]; other site 1358027003343 allosteric site; other site 1358027003344 active site lid [active] 1358027003345 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1358027003346 Fic/DOC family; Region: Fic; pfam02661 1358027003347 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1358027003348 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1358027003349 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1358027003350 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1358027003351 Walker A/P-loop; other site 1358027003352 ATP binding site [chemical binding]; other site 1358027003353 Q-loop/lid; other site 1358027003354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027003355 ABC transporter signature motif; other site 1358027003356 Walker B; other site 1358027003357 D-loop; other site 1358027003358 H-loop/switch region; other site 1358027003359 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1358027003360 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1358027003361 active site 1358027003362 metal binding site [ion binding]; metal-binding site 1358027003363 DNA binding site [nucleotide binding] 1358027003364 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1358027003365 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1358027003366 active site 1358027003367 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1358027003368 Bacterial SH3 domain; Region: SH3_5; pfam08460 1358027003369 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1358027003370 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1358027003371 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1358027003372 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1358027003373 ATP binding site [chemical binding]; other site 1358027003374 putative Mg++ binding site [ion binding]; other site 1358027003375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1358027003376 nucleotide binding region [chemical binding]; other site 1358027003377 ATP-binding site [chemical binding]; other site 1358027003378 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 1358027003379 Rib/alpha-like repeat; Region: Rib; cl07159 1358027003380 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1358027003381 PemK-like protein; Region: PemK; pfam02452 1358027003382 S-methylmethionine transporter; Provisional; Region: PRK11387 1358027003383 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 1358027003384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1358027003385 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1358027003386 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1358027003387 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1358027003388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1358027003389 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1358027003390 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1358027003391 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1358027003392 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1358027003393 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 1358027003394 putative active site [active] 1358027003395 putative nucleic acid binding site [nucleotide binding]; other site 1358027003396 AAA domain; Region: AAA_21; pfam13304 1358027003397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027003398 ABC transporter signature motif; other site 1358027003399 Walker B; other site 1358027003400 D-loop; other site 1358027003401 H-loop/switch region; other site 1358027003402 DDE superfamily endonuclease; Region: DDE_5; cl17874 1358027003403 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1358027003404 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 1358027003405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027003406 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1358027003407 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1358027003408 NAD binding site [chemical binding]; other site 1358027003409 substrate binding site [chemical binding]; other site 1358027003410 homodimer interface [polypeptide binding]; other site 1358027003411 active site 1358027003412 Domain of unknown function (DUF1919); Region: DUF1919; pfam08942 1358027003413 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1358027003414 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1358027003415 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1358027003416 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1358027003417 active site 1358027003418 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1358027003419 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1358027003420 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1358027003421 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1358027003422 active site 1358027003423 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1358027003424 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1358027003425 active site 1358027003426 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1358027003427 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1358027003428 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1358027003429 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1358027003430 Chain length determinant protein; Region: Wzz; cl15801 1358027003431 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1358027003432 Predicted transcriptional regulators [Transcription]; Region: COG1733 1358027003433 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1358027003434 Homeodomain-like domain; Region: HTH_23; pfam13384 1358027003435 glycerol kinase; Provisional; Region: glpK; PRK00047 1358027003436 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1358027003437 N- and C-terminal domain interface [polypeptide binding]; other site 1358027003438 active site 1358027003439 MgATP binding site [chemical binding]; other site 1358027003440 catalytic site [active] 1358027003441 metal binding site [ion binding]; metal-binding site 1358027003442 glycerol binding site [chemical binding]; other site 1358027003443 homotetramer interface [polypeptide binding]; other site 1358027003444 homodimer interface [polypeptide binding]; other site 1358027003445 FBP binding site [chemical binding]; other site 1358027003446 protein IIAGlc interface [polypeptide binding]; other site 1358027003447 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 1358027003448 active site 1 [active] 1358027003449 dimer interface [polypeptide binding]; other site 1358027003450 hexamer interface [polypeptide binding]; other site 1358027003451 active site 2 [active] 1358027003452 Peptidase family C69; Region: Peptidase_C69; pfam03577 1358027003453 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 1358027003454 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1358027003455 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1358027003456 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 1358027003457 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1358027003458 ATP binding site [chemical binding]; other site 1358027003459 putative Mg++ binding site [ion binding]; other site 1358027003460 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1358027003461 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1358027003462 nucleotide binding region [chemical binding]; other site 1358027003463 ATP-binding site [chemical binding]; other site 1358027003464 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 1358027003465 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 1358027003466 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 1358027003467 accessory Sec system translocase SecY2; Region: acc_sec_Y2; TIGR02920 1358027003468 SecY translocase; Region: SecY; pfam00344 1358027003469 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 1358027003470 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1358027003471 MucBP domain; Region: MucBP; pfam06458 1358027003472 MucBP domain; Region: MucBP; pfam06458 1358027003473 MucBP domain; Region: MucBP; pfam06458 1358027003474 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1358027003475 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 1358027003476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1358027003477 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1358027003478 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1358027003479 catalytic residue [active] 1358027003480 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1358027003481 catalytic residues [active] 1358027003482 peroxiredoxin; Region: AhpC; TIGR03137 1358027003483 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1358027003484 dimer interface [polypeptide binding]; other site 1358027003485 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1358027003486 catalytic triad [active] 1358027003487 peroxidatic and resolving cysteines [active] 1358027003488 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1358027003489 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1358027003490 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1358027003491 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1358027003492 active site 1358027003493 metal binding site [ion binding]; metal-binding site 1358027003494 drug efflux system protein MdtG; Provisional; Region: PRK09874 1358027003495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027003496 putative substrate translocation pore; other site 1358027003497 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1358027003498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1358027003499 S-adenosylmethionine binding site [chemical binding]; other site 1358027003500 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1358027003501 UbiA prenyltransferase family; Region: UbiA; pfam01040 1358027003502 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1358027003503 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1358027003504 substrate binding pocket [chemical binding]; other site 1358027003505 chain length determination region; other site 1358027003506 substrate-Mg2+ binding site; other site 1358027003507 catalytic residues [active] 1358027003508 aspartate-rich region 1; other site 1358027003509 active site lid residues [active] 1358027003510 aspartate-rich region 2; other site 1358027003511 PT repeat; Region: PT; pfam04886 1358027003512 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1358027003513 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1358027003514 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1358027003515 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1358027003516 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1358027003517 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1358027003518 HPr interaction site; other site 1358027003519 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1358027003520 active site 1358027003521 phosphorylation site [posttranslational modification] 1358027003522 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1358027003523 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1358027003524 DNA binding site [nucleotide binding] 1358027003525 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1358027003526 putative dimerization interface [polypeptide binding]; other site 1358027003527 putative ligand binding site [chemical binding]; other site 1358027003528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1358027003529 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1358027003530 Probable transposase; Region: OrfB_IS605; pfam01385 1358027003531 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1358027003532 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd12218 1358027003533 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 1358027003534 tetramer interface [polypeptide binding]; other site 1358027003535 putative DNA binding site [nucleotide binding]; other site 1358027003536 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 1358027003537 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1358027003538 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1358027003539 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1358027003540 active site 1358027003541 putative catalytic site [active] 1358027003542 DNA binding site [nucleotide binding] 1358027003543 putative phosphate binding site [ion binding]; other site 1358027003544 metal binding site A [ion binding]; metal-binding site 1358027003545 AP binding site [nucleotide binding]; other site 1358027003546 metal binding site B [ion binding]; metal-binding site 1358027003547 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540 1358027003548 putative metal binding site [ion binding]; other site 1358027003549 LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. The N-terminal glycosyl hydrolase...; Region: GH25_LysA-like; cd06417 1358027003550 active site 1358027003551 Bacterial SH3 domain; Region: SH3_5; pfam08460 1358027003552 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1358027003553 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1358027003554 LysM domain; Region: LysM; pfam01476 1358027003555 Mu-like prophage protein [General function prediction only]; Region: COG3941 1358027003556 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 1358027003557 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 1358027003558 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 1358027003559 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1358027003560 active site 1358027003561 conformational flexibility of ligand binding pocket; other site 1358027003562 ADP-ribosylating toxin turn-turn motif; other site 1358027003563 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1358027003564 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1358027003565 Phage terminase large subunit; Region: Terminase_3; cl12054 1358027003566 Terminase-like family; Region: Terminase_6; pfam03237 1358027003567 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1358027003568 Terminase small subunit; Region: Terminase_2; pfam03592 1358027003569 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1358027003570 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540 1358027003571 putative metal binding site [ion binding]; other site 1358027003572 NUMOD4 motif; Region: NUMOD4; pfam07463 1358027003573 HNH endonuclease; Region: HNH_3; pfam13392 1358027003574 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 1358027003575 putative transposase; Provisional; Region: PHA02942 1358027003576 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1358027003577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027003578 Walker A motif; other site 1358027003579 ATP binding site [chemical binding]; other site 1358027003580 Walker B motif; other site 1358027003581 arginine finger; other site 1358027003582 Helix-turn-helix domain; Region: HTH_36; pfam13730 1358027003583 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 1358027003584 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1358027003585 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1358027003586 dimer interface [polypeptide binding]; other site 1358027003587 ssDNA binding site [nucleotide binding]; other site 1358027003588 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1358027003589 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1358027003590 ERF superfamily; Region: ERF; pfam04404 1358027003591 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 1358027003592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1358027003593 non-specific DNA binding site [nucleotide binding]; other site 1358027003594 salt bridge; other site 1358027003595 sequence-specific DNA binding site [nucleotide binding]; other site 1358027003596 Prophage antirepressor [Transcription]; Region: COG3617 1358027003597 BRO family, N-terminal domain; Region: Bro-N; smart01040 1358027003598 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1358027003599 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1358027003600 non-specific DNA binding site [nucleotide binding]; other site 1358027003601 salt bridge; other site 1358027003602 sequence-specific DNA binding site [nucleotide binding]; other site 1358027003603 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1358027003604 non-specific DNA binding site [nucleotide binding]; other site 1358027003605 salt bridge; other site 1358027003606 sequence-specific DNA binding site [nucleotide binding]; other site 1358027003607 Domain of unknown function (DUF955); Region: DUF955; cl01076 1358027003608 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1358027003609 active site 1358027003610 DNA binding site [nucleotide binding] 1358027003611 Int/Topo IB signature motif; other site 1358027003612 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1358027003613 amino acid transporter; Region: 2A0306; TIGR00909 1358027003614 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1358027003615 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1358027003616 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1358027003617 RimM N-terminal domain; Region: RimM; pfam01782 1358027003618 PRC-barrel domain; Region: PRC; pfam05239 1358027003619 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1358027003620 KH domain; Region: KH_4; pfam13083 1358027003621 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1358027003622 signal recognition particle protein; Provisional; Region: PRK10867 1358027003623 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1358027003624 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1358027003625 P loop; other site 1358027003626 GTP binding site [chemical binding]; other site 1358027003627 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1358027003628 putative DNA-binding protein; Validated; Region: PRK00118 1358027003629 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1358027003630 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1358027003631 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1358027003632 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1358027003633 P loop; other site 1358027003634 GTP binding site [chemical binding]; other site 1358027003635 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1358027003636 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1358027003637 Walker A/P-loop; other site 1358027003638 ATP binding site [chemical binding]; other site 1358027003639 Q-loop/lid; other site 1358027003640 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1358027003641 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1358027003642 ABC transporter signature motif; other site 1358027003643 Walker B; other site 1358027003644 D-loop; other site 1358027003645 H-loop/switch region; other site 1358027003646 ribonuclease III; Reviewed; Region: rnc; PRK00102 1358027003647 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1358027003648 dimerization interface [polypeptide binding]; other site 1358027003649 active site 1358027003650 metal binding site [ion binding]; metal-binding site 1358027003651 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1358027003652 dsRNA binding site [nucleotide binding]; other site 1358027003653 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1358027003654 Integrase core domain; Region: rve; pfam00665 1358027003655 acyl carrier protein; Provisional; Region: acpP; PRK00982 1358027003656 putative phosphate acyltransferase; Provisional; Region: PRK05331 1358027003657 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1358027003658 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1358027003659 generic binding surface II; other site 1358027003660 ssDNA binding site; other site 1358027003661 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1358027003662 ATP binding site [chemical binding]; other site 1358027003663 putative Mg++ binding site [ion binding]; other site 1358027003664 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1358027003665 nucleotide binding region [chemical binding]; other site 1358027003666 ATP-binding site [chemical binding]; other site 1358027003667 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1358027003668 DAK2 domain; Region: Dak2; pfam02734 1358027003669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1358027003670 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1358027003671 Thiamine pyrophosphokinase; Region: TPK; cd07995 1358027003672 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1358027003673 active site 1358027003674 dimerization interface [polypeptide binding]; other site 1358027003675 thiamine binding site [chemical binding]; other site 1358027003676 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1358027003677 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1358027003678 substrate binding site [chemical binding]; other site 1358027003679 hexamer interface [polypeptide binding]; other site 1358027003680 metal binding site [ion binding]; metal-binding site 1358027003681 GTPase RsgA; Reviewed; Region: PRK00098 1358027003682 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1358027003683 RNA binding site [nucleotide binding]; other site 1358027003684 homodimer interface [polypeptide binding]; other site 1358027003685 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1358027003686 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1358027003687 GTP/Mg2+ binding site [chemical binding]; other site 1358027003688 G4 box; other site 1358027003689 G5 box; other site 1358027003690 G1 box; other site 1358027003691 Switch I region; other site 1358027003692 G2 box; other site 1358027003693 G3 box; other site 1358027003694 Switch II region; other site 1358027003695 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1358027003696 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1358027003697 active site 1358027003698 ATP binding site [chemical binding]; other site 1358027003699 substrate binding site [chemical binding]; other site 1358027003700 activation loop (A-loop); other site 1358027003701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1358027003702 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1358027003703 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1358027003704 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1358027003705 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1358027003706 active site 1358027003707 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1358027003708 NusB family; Region: NusB; pfam01029 1358027003709 putative RNA binding site [nucleotide binding]; other site 1358027003710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1358027003711 S-adenosylmethionine binding site [chemical binding]; other site 1358027003712 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1358027003713 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1358027003714 putative active site [active] 1358027003715 substrate binding site [chemical binding]; other site 1358027003716 putative cosubstrate binding site; other site 1358027003717 catalytic site [active] 1358027003718 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1358027003719 substrate binding site [chemical binding]; other site 1358027003720 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1358027003721 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1358027003722 ATP binding site [chemical binding]; other site 1358027003723 putative Mg++ binding site [ion binding]; other site 1358027003724 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1358027003725 nucleotide binding region [chemical binding]; other site 1358027003726 ATP-binding site [chemical binding]; other site 1358027003727 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1358027003728 Flavoprotein; Region: Flavoprotein; pfam02441 1358027003729 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1358027003730 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1358027003731 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1358027003732 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1358027003733 catalytic site [active] 1358027003734 G-X2-G-X-G-K; other site 1358027003735 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1358027003736 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1358027003737 Walker A/P-loop; other site 1358027003738 ATP binding site [chemical binding]; other site 1358027003739 Q-loop/lid; other site 1358027003740 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1358027003741 ABC transporter signature motif; other site 1358027003742 Walker B; other site 1358027003743 D-loop; other site 1358027003744 H-loop/switch region; other site 1358027003745 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1358027003746 arginine repressor; Provisional; Region: PRK04280 1358027003747 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1358027003748 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1358027003749 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1358027003750 RNA binding surface [nucleotide binding]; other site 1358027003751 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1358027003752 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1358027003753 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1358027003754 substrate binding pocket [chemical binding]; other site 1358027003755 chain length determination region; other site 1358027003756 substrate-Mg2+ binding site; other site 1358027003757 catalytic residues [active] 1358027003758 aspartate-rich region 1; other site 1358027003759 active site lid residues [active] 1358027003760 aspartate-rich region 2; other site 1358027003761 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1358027003762 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1358027003763 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1358027003764 generic binding surface II; other site 1358027003765 generic binding surface I; other site 1358027003766 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1358027003767 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1358027003768 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1358027003769 homodimer interface [polypeptide binding]; other site 1358027003770 NADP binding site [chemical binding]; other site 1358027003771 substrate binding site [chemical binding]; other site 1358027003772 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1358027003773 putative RNA binding site [nucleotide binding]; other site 1358027003774 Asp23 family; Region: Asp23; pfam03780 1358027003775 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1358027003776 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1358027003777 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1358027003778 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1358027003779 active site 1358027003780 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1358027003781 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1358027003782 catalytic residue [active] 1358027003783 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1358027003784 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1358027003785 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1358027003786 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1358027003787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1358027003788 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1358027003789 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1358027003790 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1358027003791 putative active site [active] 1358027003792 putative NTP binding site [chemical binding]; other site 1358027003793 putative nucleic acid binding site [nucleotide binding]; other site 1358027003794 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1358027003795 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1358027003796 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1358027003797 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1358027003798 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1358027003799 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1358027003800 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1358027003801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1358027003802 homodimer interface [polypeptide binding]; other site 1358027003803 catalytic residue [active] 1358027003804 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1358027003805 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1358027003806 active site 1358027003807 HIGH motif; other site 1358027003808 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1358027003809 active site 1358027003810 KMSKS motif; other site 1358027003811 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1358027003812 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1358027003813 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1358027003814 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1358027003815 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1358027003816 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1358027003817 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 1358027003818 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1358027003819 active site residue [active] 1358027003820 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1358027003821 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1358027003822 nucleotide binding site [chemical binding]; other site 1358027003823 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1358027003824 Rhomboid family; Region: Rhomboid; pfam01694 1358027003825 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1358027003826 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1358027003827 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1358027003828 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1358027003829 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1358027003830 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1358027003831 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1358027003832 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1358027003833 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1358027003834 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1358027003835 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1358027003836 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1358027003837 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1358027003838 Sugar specificity; other site 1358027003839 Pyrimidine base specificity; other site 1358027003840 ATP-binding site [chemical binding]; other site 1358027003841 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1358027003842 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1358027003843 NlpC/P60 family; Region: NLPC_P60; pfam00877 1358027003844 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1358027003845 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1358027003846 putative tRNA-binding site [nucleotide binding]; other site 1358027003847 B3/4 domain; Region: B3_4; pfam03483 1358027003848 tRNA synthetase B5 domain; Region: B5; smart00874 1358027003849 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1358027003850 dimer interface [polypeptide binding]; other site 1358027003851 motif 1; other site 1358027003852 motif 3; other site 1358027003853 motif 2; other site 1358027003854 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1358027003855 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1358027003856 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1358027003857 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1358027003858 dimer interface [polypeptide binding]; other site 1358027003859 motif 1; other site 1358027003860 active site 1358027003861 motif 2; other site 1358027003862 motif 3; other site 1358027003863 Predicted transcriptional regulators [Transcription]; Region: COG1733 1358027003864 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1358027003865 HD domain; Region: HD; pfam01966 1358027003866 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1358027003867 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1358027003868 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1358027003869 Acylphosphatase; Region: Acylphosphatase; pfam00708 1358027003870 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1358027003871 OxaA-like protein precursor; Provisional; Region: PRK02463 1358027003872 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1358027003873 active site 1358027003874 catalytic residues [active] 1358027003875 metal binding site [ion binding]; metal-binding site 1358027003876 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1358027003877 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1358027003878 inner membrane transporter YjeM; Provisional; Region: PRK15238 1358027003879 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1358027003880 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1358027003881 dimerization interface [polypeptide binding]; other site 1358027003882 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1358027003883 dimer interface [polypeptide binding]; other site 1358027003884 phosphorylation site [posttranslational modification] 1358027003885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1358027003886 ATP binding site [chemical binding]; other site 1358027003887 Mg2+ binding site [ion binding]; other site 1358027003888 G-X-G motif; other site 1358027003889 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1358027003890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1358027003891 active site 1358027003892 phosphorylation site [posttranslational modification] 1358027003893 intermolecular recognition site; other site 1358027003894 dimerization interface [polypeptide binding]; other site 1358027003895 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1358027003896 DNA binding site [nucleotide binding] 1358027003897 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1358027003898 Integrase core domain; Region: rve; pfam00665 1358027003899 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1358027003900 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1358027003901 hypothetical protein; Provisional; Region: PRK13670 1358027003902 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1358027003903 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1358027003904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1358027003905 S-adenosylmethionine binding site [chemical binding]; other site 1358027003906 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1358027003907 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1358027003908 Zn2+ binding site [ion binding]; other site 1358027003909 Mg2+ binding site [ion binding]; other site 1358027003910 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1358027003911 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1358027003912 active site 1358027003913 (T/H)XGH motif; other site 1358027003914 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1358027003915 GTPase YqeH; Provisional; Region: PRK13796 1358027003916 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1358027003917 GTP/Mg2+ binding site [chemical binding]; other site 1358027003918 G4 box; other site 1358027003919 G5 box; other site 1358027003920 G1 box; other site 1358027003921 Switch I region; other site 1358027003922 G2 box; other site 1358027003923 G3 box; other site 1358027003924 Switch II region; other site 1358027003925 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1358027003926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1358027003927 active site 1358027003928 motif I; other site 1358027003929 motif II; other site 1358027003930 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1358027003931 23S rRNA binding site [nucleotide binding]; other site 1358027003932 L21 binding site [polypeptide binding]; other site 1358027003933 L13 binding site [polypeptide binding]; other site 1358027003934 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1358027003935 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1358027003936 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1358027003937 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1358027003938 primosomal protein DnaI; Reviewed; Region: PRK08939 1358027003939 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1358027003940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027003941 Walker A motif; other site 1358027003942 ATP binding site [chemical binding]; other site 1358027003943 Walker B motif; other site 1358027003944 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1358027003945 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1358027003946 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1358027003947 ATP cone domain; Region: ATP-cone; pfam03477 1358027003948 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1358027003949 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1358027003950 CoA-binding site [chemical binding]; other site 1358027003951 ATP-binding [chemical binding]; other site 1358027003952 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1358027003953 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1358027003954 DNA binding site [nucleotide binding] 1358027003955 catalytic residue [active] 1358027003956 H2TH interface [polypeptide binding]; other site 1358027003957 putative catalytic residues [active] 1358027003958 turnover-facilitating residue; other site 1358027003959 intercalation triad [nucleotide binding]; other site 1358027003960 8OG recognition residue [nucleotide binding]; other site 1358027003961 putative reading head residues; other site 1358027003962 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1358027003963 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1358027003964 DNA polymerase I; Provisional; Region: PRK05755 1358027003965 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1358027003966 active site 1358027003967 metal binding site 1 [ion binding]; metal-binding site 1358027003968 putative 5' ssDNA interaction site; other site 1358027003969 metal binding site 3; metal-binding site 1358027003970 metal binding site 2 [ion binding]; metal-binding site 1358027003971 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1358027003972 putative DNA binding site [nucleotide binding]; other site 1358027003973 putative metal binding site [ion binding]; other site 1358027003974 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1358027003975 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1358027003976 active site 1358027003977 DNA binding site [nucleotide binding] 1358027003978 catalytic site [active] 1358027003979 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1358027003980 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1358027003981 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1358027003982 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1358027003983 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1358027003984 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1358027003985 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1358027003986 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1358027003987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1358027003988 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1358027003989 putative tRNA-binding site [nucleotide binding]; other site 1358027003990 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1358027003991 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1358027003992 catalytic residues [active] 1358027003993 Predicted small secreted protein [Function unknown]; Region: COG5584 1358027003994 glutaminase A; Region: Gln_ase; TIGR03814 1358027003995 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1358027003996 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1358027003997 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1358027003998 active site 1358027003999 catalytic tetrad [active] 1358027004000 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1358027004001 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1358027004002 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1358027004003 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1358027004004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1358027004005 S-adenosylmethionine binding site [chemical binding]; other site 1358027004006 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1358027004007 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1358027004008 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1358027004009 Walker A/P-loop; other site 1358027004010 ATP binding site [chemical binding]; other site 1358027004011 Q-loop/lid; other site 1358027004012 ABC transporter signature motif; other site 1358027004013 Walker B; other site 1358027004014 D-loop; other site 1358027004015 H-loop/switch region; other site 1358027004016 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1358027004017 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 1358027004018 HIT family signature motif; other site 1358027004019 catalytic residue [active] 1358027004020 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 1358027004021 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1358027004022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027004023 AAA domain; Region: AAA_23; pfam13476 1358027004024 Walker A/P-loop; other site 1358027004025 ATP binding site [chemical binding]; other site 1358027004026 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1358027004027 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1358027004028 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1358027004029 active site 1358027004030 metal binding site [ion binding]; metal-binding site 1358027004031 DNA binding site [nucleotide binding] 1358027004032 Protein of unknown function (DUF964); Region: DUF964; cl01483 1358027004033 Transglycosylase; Region: Transgly; pfam00912 1358027004034 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1358027004035 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1358027004036 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1358027004037 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1358027004038 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1358027004039 active site 1358027004040 HIGH motif; other site 1358027004041 KMSK motif region; other site 1358027004042 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1358027004043 tRNA binding surface [nucleotide binding]; other site 1358027004044 anticodon binding site; other site 1358027004045 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1358027004046 dimer interface [polypeptide binding]; other site 1358027004047 substrate binding site [chemical binding]; other site 1358027004048 ATP binding site [chemical binding]; other site 1358027004049 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1358027004050 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1358027004051 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1358027004052 NAD binding site [chemical binding]; other site 1358027004053 dimer interface [polypeptide binding]; other site 1358027004054 substrate binding site [chemical binding]; other site 1358027004055 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1358027004056 dihydropteroate synthase; Region: DHPS; TIGR01496 1358027004057 substrate binding pocket [chemical binding]; other site 1358027004058 dimer interface [polypeptide binding]; other site 1358027004059 inhibitor binding site; inhibition site 1358027004060 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1358027004061 active site 1358027004062 dimerization interface [polypeptide binding]; other site 1358027004063 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1358027004064 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1358027004065 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1358027004066 GTP cyclohydrolase I; Provisional; Region: PLN03044 1358027004067 active site 1358027004068 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1358027004069 catalytic center binding site [active] 1358027004070 ATP binding site [chemical binding]; other site 1358027004071 Dihydroneopterin aldolase; Region: FolB; pfam02152 1358027004072 active site 1358027004073 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1358027004074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1358027004075 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1358027004076 Probable transposase; Region: OrfB_IS605; pfam01385 1358027004077 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1358027004078 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 1358027004079 CAAX protease self-immunity; Region: Abi; pfam02517 1358027004080 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1358027004081 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1358027004082 DNA binding site [nucleotide binding] 1358027004083 domain linker motif; other site 1358027004084 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1358027004085 dimerization interface [polypeptide binding]; other site 1358027004086 ligand binding site [chemical binding]; other site 1358027004087 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1358027004088 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1358027004089 Substrate-binding site [chemical binding]; other site 1358027004090 Substrate specificity [chemical binding]; other site 1358027004091 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1358027004092 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1358027004093 Ligand Binding Site [chemical binding]; other site 1358027004094 dipeptidase PepV; Reviewed; Region: PRK07318 1358027004095 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1358027004096 active site 1358027004097 metal binding site [ion binding]; metal-binding site 1358027004098 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1358027004099 putative substrate binding site [chemical binding]; other site 1358027004100 putative ATP binding site [chemical binding]; other site 1358027004101 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1358027004102 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1358027004103 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1358027004104 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1358027004105 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1358027004106 HIGH motif; other site 1358027004107 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1358027004108 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1358027004109 active site 1358027004110 KMSKS motif; other site 1358027004111 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1358027004112 tRNA binding surface [nucleotide binding]; other site 1358027004113 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1358027004114 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1358027004115 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1358027004116 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1358027004117 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1358027004118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027004119 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1358027004120 putative substrate translocation pore; other site 1358027004121 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1358027004122 metal binding site 2 [ion binding]; metal-binding site 1358027004123 putative DNA binding helix; other site 1358027004124 metal binding site 1 [ion binding]; metal-binding site 1358027004125 dimer interface [polypeptide binding]; other site 1358027004126 structural Zn2+ binding site [ion binding]; other site 1358027004127 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1358027004128 VanZ like family; Region: VanZ; pfam04892 1358027004129 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1358027004130 DNA polymerase IV; Reviewed; Region: PRK03103 1358027004131 Y-family of DNA polymerases; Region: PolY; cl12025 1358027004132 active site 1358027004133 DNA binding site [nucleotide binding] 1358027004134 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1358027004135 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1358027004136 putative dimer interface [polypeptide binding]; other site 1358027004137 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1358027004138 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1358027004139 active site 1358027004140 catalytic tetrad [active] 1358027004141 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1358027004142 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1358027004143 homodimer interface [polypeptide binding]; other site 1358027004144 active site 1358027004145 FMN binding site [chemical binding]; other site 1358027004146 substrate binding site [chemical binding]; other site 1358027004147 4Fe-4S binding domain; Region: Fer4; pfam00037 1358027004148 4Fe-4S binding domain; Region: Fer4; pfam00037 1358027004149 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1358027004150 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1358027004151 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1358027004152 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1358027004153 active site 1358027004154 putative catalytic site [active] 1358027004155 DNA binding site [nucleotide binding] 1358027004156 putative phosphate binding site [ion binding]; other site 1358027004157 metal binding site A [ion binding]; metal-binding site 1358027004158 AP binding site [nucleotide binding]; other site 1358027004159 metal binding site B [ion binding]; metal-binding site 1358027004160 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1358027004161 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1358027004162 putative active site [active] 1358027004163 putative NTP binding site [chemical binding]; other site 1358027004164 putative nucleic acid binding site [nucleotide binding]; other site 1358027004165 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1358027004166 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1358027004167 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1358027004168 active site 1358027004169 metal-binding site [ion binding] 1358027004170 nucleotide-binding site [chemical binding]; other site 1358027004171 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1358027004172 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1358027004173 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1358027004174 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1358027004175 FeS/SAM binding site; other site 1358027004176 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1358027004177 ATP cone domain; Region: ATP-cone; pfam03477 1358027004178 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1358027004179 effector binding site; other site 1358027004180 active site 1358027004181 Zn binding site [ion binding]; other site 1358027004182 glycine loop; other site 1358027004183 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1358027004184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027004185 putative substrate translocation pore; other site 1358027004186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1358027004187 Coenzyme A binding pocket [chemical binding]; other site 1358027004188 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1358027004189 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1358027004190 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1358027004191 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1358027004192 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1358027004193 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 1358027004194 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1358027004195 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1358027004196 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1358027004197 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1358027004198 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1358027004199 putative ADP-binding pocket [chemical binding]; other site 1358027004200 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1358027004201 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1358027004202 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1358027004203 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1358027004204 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1358027004205 dimerization domain swap beta strand [polypeptide binding]; other site 1358027004206 regulatory protein interface [polypeptide binding]; other site 1358027004207 active site 1358027004208 regulatory phosphorylation site [posttranslational modification]; other site 1358027004209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027004210 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1358027004211 Walker A motif; other site 1358027004212 ATP binding site [chemical binding]; other site 1358027004213 Walker B motif; other site 1358027004214 arginine finger; other site 1358027004215 UvrB/uvrC motif; Region: UVR; pfam02151 1358027004216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027004217 Walker A motif; other site 1358027004218 ATP binding site [chemical binding]; other site 1358027004219 Walker B motif; other site 1358027004220 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1358027004221 Predicted membrane protein [Function unknown]; Region: COG4684 1358027004222 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1358027004223 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1358027004224 Bacterial SH3 domain; Region: SH3_3; cl17532 1358027004225 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1358027004226 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1358027004227 Walker A/P-loop; other site 1358027004228 ATP binding site [chemical binding]; other site 1358027004229 Q-loop/lid; other site 1358027004230 ABC transporter signature motif; other site 1358027004231 Walker B; other site 1358027004232 D-loop; other site 1358027004233 H-loop/switch region; other site 1358027004234 Predicted transcriptional regulators [Transcription]; Region: COG1725 1358027004235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1358027004236 DNA-binding site [nucleotide binding]; DNA binding site 1358027004237 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1358027004238 Peptidase family M23; Region: Peptidase_M23; pfam01551 1358027004239 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1358027004240 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1358027004241 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1358027004242 NlpC/P60 family; Region: NLPC_P60; cl17555 1358027004243 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1358027004244 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1358027004245 G1 box; other site 1358027004246 putative GEF interaction site [polypeptide binding]; other site 1358027004247 GTP/Mg2+ binding site [chemical binding]; other site 1358027004248 Switch I region; other site 1358027004249 G2 box; other site 1358027004250 G3 box; other site 1358027004251 Switch II region; other site 1358027004252 G4 box; other site 1358027004253 G5 box; other site 1358027004254 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1358027004255 Sulfatase; Region: Sulfatase; cl17466 1358027004256 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1358027004257 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1358027004258 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1358027004259 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1358027004260 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1358027004261 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1358027004262 active site 1358027004263 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1358027004264 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1358027004265 NADP binding site [chemical binding]; other site 1358027004266 active site 1358027004267 putative substrate binding site [chemical binding]; other site 1358027004268 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1358027004269 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1358027004270 NAD binding site [chemical binding]; other site 1358027004271 substrate binding site [chemical binding]; other site 1358027004272 homodimer interface [polypeptide binding]; other site 1358027004273 active site 1358027004274 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1358027004275 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1358027004276 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1358027004277 substrate binding site; other site 1358027004278 tetramer interface; other site 1358027004279 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1358027004280 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1358027004281 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1358027004282 Ligand binding site; other site 1358027004283 Putative Catalytic site; other site 1358027004284 DXD motif; other site 1358027004285 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1358027004286 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1358027004287 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1358027004288 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 1358027004289 Probable Catalytic site; other site 1358027004290 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1358027004291 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1358027004292 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1358027004293 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1358027004294 Probable Catalytic site; other site 1358027004295 Chain length determinant protein; Region: Wzz; cl15801 1358027004296 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1358027004297 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1358027004298 active site 1358027004299 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1358027004300 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1358027004301 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1358027004302 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1358027004303 UDP-galactopyranose mutase; Region: GLF; pfam03275 1358027004304 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1358027004305 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1358027004306 putative active site [active] 1358027004307 Peptidase family M23; Region: Peptidase_M23; pfam01551 1358027004308 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1358027004309 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1358027004310 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1358027004311 Ligand binding site; other site 1358027004312 Putative Catalytic site; other site 1358027004313 DXD motif; other site 1358027004314 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1358027004315 recombination regulator RecX; Provisional; Region: recX; PRK14135 1358027004316 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1358027004317 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1358027004318 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1358027004319 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1358027004320 putative active site [active] 1358027004321 putative NTP binding site [chemical binding]; other site 1358027004322 putative nucleic acid binding site [nucleotide binding]; other site 1358027004323 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1358027004324 inner membrane transporter YjeM; Provisional; Region: PRK15238 1358027004325 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1358027004326 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1358027004327 active site 1358027004328 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1358027004329 Predicted membrane protein [Function unknown]; Region: COG2246 1358027004330 GtrA-like protein; Region: GtrA; pfam04138 1358027004331 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1358027004332 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1358027004333 active site 1358027004334 homodimer interface [polypeptide binding]; other site 1358027004335 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1358027004336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1358027004337 ATP binding site [chemical binding]; other site 1358027004338 putative Mg++ binding site [ion binding]; other site 1358027004339 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1358027004340 nucleotide binding region [chemical binding]; other site 1358027004341 ATP-binding site [chemical binding]; other site 1358027004342 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1358027004343 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1358027004344 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1358027004345 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1358027004346 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1358027004347 NAD(P) binding site [chemical binding]; other site 1358027004348 LDH/MDH dimer interface [polypeptide binding]; other site 1358027004349 substrate binding site [chemical binding]; other site 1358027004350 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1358027004351 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 1358027004352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1358027004353 Coenzyme A binding pocket [chemical binding]; other site 1358027004354 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1358027004355 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1358027004356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027004357 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1358027004358 putative substrate translocation pore; other site 1358027004359 LytTr DNA-binding domain; Region: LytTR; smart00850 1358027004360 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1358027004361 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1358027004362 substrate binding site [chemical binding]; other site 1358027004363 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1358027004364 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1358027004365 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1358027004366 putative FMN binding site [chemical binding]; other site 1358027004367 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1358027004368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1358027004369 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1358027004370 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1358027004371 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1358027004372 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1358027004373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1358027004374 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1358027004375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1358027004376 Coenzyme A binding pocket [chemical binding]; other site 1358027004377 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1358027004378 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1358027004379 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1358027004380 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1358027004381 ligand binding site [chemical binding]; other site 1358027004382 flexible hinge region; other site 1358027004383 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 1358027004384 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1358027004385 dinuclear metal binding motif [ion binding]; other site 1358027004386 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1358027004387 metal-binding site [ion binding] 1358027004388 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1358027004389 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1358027004390 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1358027004391 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1358027004392 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1358027004393 Helix-turn-helix domain; Region: HTH_28; pfam13518 1358027004394 Integrase core domain; Region: rve; pfam00665 1358027004395 Integrase core domain; Region: rve_3; pfam13683 1358027004396 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1358027004397 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1358027004398 putative active site [active] 1358027004399 putative NTP binding site [chemical binding]; other site 1358027004400 putative nucleic acid binding site [nucleotide binding]; other site 1358027004401 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1358027004402 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1358027004403 dimer interface [polypeptide binding]; other site 1358027004404 catalytic triad [active] 1358027004405 peroxidatic and resolving cysteines [active] 1358027004406 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1358027004407 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1358027004408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1358027004409 S-adenosylmethionine binding site [chemical binding]; other site 1358027004410 putative lipid kinase; Reviewed; Region: PRK13055 1358027004411 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1358027004412 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1358027004413 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1358027004414 GatB domain; Region: GatB_Yqey; smart00845 1358027004415 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1358027004416 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1358027004417 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1358027004418 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1358027004419 putative dimer interface [polypeptide binding]; other site 1358027004420 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 1358027004421 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1358027004422 putative dimer interface [polypeptide binding]; other site 1358027004423 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1358027004424 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1358027004425 nucleotide binding pocket [chemical binding]; other site 1358027004426 K-X-D-G motif; other site 1358027004427 catalytic site [active] 1358027004428 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1358027004429 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1358027004430 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1358027004431 Dimer interface [polypeptide binding]; other site 1358027004432 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1358027004433 Part of AAA domain; Region: AAA_19; pfam13245 1358027004434 Family description; Region: UvrD_C_2; pfam13538 1358027004435 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1358027004436 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1358027004437 active site 1358027004438 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1358027004439 acetoin reductase; Validated; Region: PRK08643 1358027004440 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1358027004441 NAD binding site [chemical binding]; other site 1358027004442 homotetramer interface [polypeptide binding]; other site 1358027004443 homodimer interface [polypeptide binding]; other site 1358027004444 active site 1358027004445 substrate binding site [chemical binding]; other site 1358027004446 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1358027004447 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1358027004448 23S rRNA interface [nucleotide binding]; other site 1358027004449 L3 interface [polypeptide binding]; other site 1358027004450 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1358027004451 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1358027004452 dimerization interface 3.5A [polypeptide binding]; other site 1358027004453 active site 1358027004454 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1358027004455 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1358027004456 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1358027004457 Walker A/P-loop; other site 1358027004458 ATP binding site [chemical binding]; other site 1358027004459 Q-loop/lid; other site 1358027004460 ABC transporter signature motif; other site 1358027004461 Walker B; other site 1358027004462 D-loop; other site 1358027004463 H-loop/switch region; other site 1358027004464 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1358027004465 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1358027004466 Walker A/P-loop; other site 1358027004467 ATP binding site [chemical binding]; other site 1358027004468 Q-loop/lid; other site 1358027004469 ABC transporter signature motif; other site 1358027004470 Walker B; other site 1358027004471 D-loop; other site 1358027004472 H-loop/switch region; other site 1358027004473 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1358027004474 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1358027004475 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1358027004476 alphaNTD homodimer interface [polypeptide binding]; other site 1358027004477 alphaNTD - beta interaction site [polypeptide binding]; other site 1358027004478 alphaNTD - beta' interaction site [polypeptide binding]; other site 1358027004479 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1358027004480 30S ribosomal protein S11; Validated; Region: PRK05309 1358027004481 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1358027004482 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1358027004483 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1358027004484 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1358027004485 rRNA binding site [nucleotide binding]; other site 1358027004486 predicted 30S ribosome binding site; other site 1358027004487 adenylate kinase; Reviewed; Region: adk; PRK00279 1358027004488 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1358027004489 AMP-binding site [chemical binding]; other site 1358027004490 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1358027004491 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1358027004492 SecY translocase; Region: SecY; pfam00344 1358027004493 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1358027004494 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1358027004495 23S rRNA binding site [nucleotide binding]; other site 1358027004496 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1358027004497 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1358027004498 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1358027004499 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1358027004500 5S rRNA interface [nucleotide binding]; other site 1358027004501 L27 interface [polypeptide binding]; other site 1358027004502 23S rRNA interface [nucleotide binding]; other site 1358027004503 L5 interface [polypeptide binding]; other site 1358027004504 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1358027004505 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1358027004506 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1358027004507 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1358027004508 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1358027004509 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1358027004510 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1358027004511 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1358027004512 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1358027004513 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1358027004514 RNA binding site [nucleotide binding]; other site 1358027004515 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1358027004516 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1358027004517 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1358027004518 23S rRNA interface [nucleotide binding]; other site 1358027004519 putative translocon interaction site; other site 1358027004520 signal recognition particle (SRP54) interaction site; other site 1358027004521 L23 interface [polypeptide binding]; other site 1358027004522 trigger factor interaction site; other site 1358027004523 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1358027004524 23S rRNA interface [nucleotide binding]; other site 1358027004525 5S rRNA interface [nucleotide binding]; other site 1358027004526 putative antibiotic binding site [chemical binding]; other site 1358027004527 L25 interface [polypeptide binding]; other site 1358027004528 L27 interface [polypeptide binding]; other site 1358027004529 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1358027004530 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1358027004531 G-X-X-G motif; other site 1358027004532 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1358027004533 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1358027004534 putative translocon binding site; other site 1358027004535 protein-rRNA interface [nucleotide binding]; other site 1358027004536 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1358027004537 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1358027004538 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1358027004539 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1358027004540 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1358027004541 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1358027004542 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1358027004543 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1358027004544 elongation factor G; Reviewed; Region: PRK12739 1358027004545 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1358027004546 G1 box; other site 1358027004547 putative GEF interaction site [polypeptide binding]; other site 1358027004548 GTP/Mg2+ binding site [chemical binding]; other site 1358027004549 Switch I region; other site 1358027004550 G2 box; other site 1358027004551 G3 box; other site 1358027004552 Switch II region; other site 1358027004553 G4 box; other site 1358027004554 G5 box; other site 1358027004555 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1358027004556 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1358027004557 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1358027004558 30S ribosomal protein S7; Validated; Region: PRK05302 1358027004559 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1358027004560 S17 interaction site [polypeptide binding]; other site 1358027004561 S8 interaction site; other site 1358027004562 16S rRNA interaction site [nucleotide binding]; other site 1358027004563 streptomycin interaction site [chemical binding]; other site 1358027004564 23S rRNA interaction site [nucleotide binding]; other site 1358027004565 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1358027004566 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1358027004567 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1358027004568 Predicted membrane protein [Function unknown]; Region: COG3371 1358027004569 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1358027004570 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1358027004571 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1358027004572 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1358027004573 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1358027004574 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1358027004575 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1358027004576 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1358027004577 G-loop; other site 1358027004578 DNA binding site [nucleotide binding] 1358027004579 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1358027004580 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1358027004581 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1358027004582 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1358027004583 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1358027004584 RPB1 interaction site [polypeptide binding]; other site 1358027004585 RPB12 interaction site [polypeptide binding]; other site 1358027004586 RPB10 interaction site [polypeptide binding]; other site 1358027004587 RPB11 interaction site [polypeptide binding]; other site 1358027004588 RPB3 interaction site [polypeptide binding]; other site 1358027004589 RPB12 interaction site [polypeptide binding]; other site 1358027004590 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1358027004591 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1358027004592 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1358027004593 Clp amino terminal domain; Region: Clp_N; pfam02861 1358027004594 Clp amino terminal domain; Region: Clp_N; pfam02861 1358027004595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027004596 Walker A motif; other site 1358027004597 ATP binding site [chemical binding]; other site 1358027004598 Walker B motif; other site 1358027004599 arginine finger; other site 1358027004600 UvrB/uvrC motif; Region: UVR; pfam02151 1358027004601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027004602 Walker A motif; other site 1358027004603 ATP binding site [chemical binding]; other site 1358027004604 Walker B motif; other site 1358027004605 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1358027004606 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1358027004607 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1358027004608 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1358027004609 NAD binding site [chemical binding]; other site 1358027004610 substrate binding site [chemical binding]; other site 1358027004611 catalytic Zn binding site [ion binding]; other site 1358027004612 tetramer interface [polypeptide binding]; other site 1358027004613 structural Zn binding site [ion binding]; other site 1358027004614 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1358027004615 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1358027004616 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1358027004617 Substrate-binding site [chemical binding]; other site 1358027004618 Substrate specificity [chemical binding]; other site 1358027004619 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 1358027004620 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1358027004621 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1358027004622 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1358027004623 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1358027004624 active site 1358027004625 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1358027004626 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1358027004627 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1358027004628 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1358027004629 DNA-binding site [nucleotide binding]; DNA binding site 1358027004630 RNA-binding motif; other site 1358027004631 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1358027004632 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1358027004633 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1358027004634 FeoA domain; Region: FeoA; pfam04023 1358027004635 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1358027004636 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1358027004637 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1358027004638 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1358027004639 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1358027004640 Ligand Binding Site [chemical binding]; other site 1358027004641 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1358027004642 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1358027004643 Walker A/P-loop; other site 1358027004644 ATP binding site [chemical binding]; other site 1358027004645 Q-loop/lid; other site 1358027004646 ABC transporter signature motif; other site 1358027004647 Walker B; other site 1358027004648 D-loop; other site 1358027004649 H-loop/switch region; other site 1358027004650 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1358027004651 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1358027004652 substrate binding pocket [chemical binding]; other site 1358027004653 membrane-bound complex binding site; other site 1358027004654 hinge residues; other site 1358027004655 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1358027004656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1358027004657 dimer interface [polypeptide binding]; other site 1358027004658 conserved gate region; other site 1358027004659 putative PBP binding loops; other site 1358027004660 ABC-ATPase subunit interface; other site 1358027004661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1358027004662 dimer interface [polypeptide binding]; other site 1358027004663 conserved gate region; other site 1358027004664 putative PBP binding loops; other site 1358027004665 ABC-ATPase subunit interface; other site 1358027004666 CAAX protease self-immunity; Region: Abi; pfam02517 1358027004667 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1358027004668 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1358027004669 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1358027004670 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1358027004671 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1358027004672 DNA binding residues [nucleotide binding] 1358027004673 putative dimer interface [polypeptide binding]; other site 1358027004674 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1358027004675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027004676 putative substrate translocation pore; other site 1358027004677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027004678 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1358027004679 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1358027004680 active site 1358027004681 Predicted integral membrane protein [Function unknown]; Region: COG0392 1358027004682 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1358027004683 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1358027004684 DJ-1 family protein; Region: not_thiJ; TIGR01383 1358027004685 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1358027004686 conserved cys residue [active] 1358027004687 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1358027004688 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1358027004689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027004690 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1358027004691 putative substrate translocation pore; other site 1358027004692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027004693 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1358027004694 Fe-S cluster binding site [ion binding]; other site 1358027004695 active site 1358027004696 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1358027004697 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1358027004698 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1358027004699 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1358027004700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1358027004701 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1358027004702 dimerization interface [polypeptide binding]; other site 1358027004703 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1358027004704 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1358027004705 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 1358027004706 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 1358027004707 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1358027004708 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1358027004709 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1358027004710 citrate lyase subunit gamma; Provisional; Region: PRK13253 1358027004711 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1358027004712 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1358027004713 active site 1358027004714 nucleotide binding site [chemical binding]; other site 1358027004715 HIGH motif; other site 1358027004716 KMSKS motif; other site 1358027004717 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1358027004718 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1358027004719 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 1358027004720 NAD(P) binding pocket [chemical binding]; other site 1358027004721 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1358027004722 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1358027004723 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1358027004724 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1358027004725 transmembrane helices; other site 1358027004726 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1358027004727 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1358027004728 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1358027004729 NAD binding site [chemical binding]; other site 1358027004730 dimer interface [polypeptide binding]; other site 1358027004731 substrate binding site [chemical binding]; other site 1358027004732 L-aspartate oxidase; Provisional; Region: PRK06175 1358027004733 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1358027004734 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1358027004735 Class II fumarases; Region: Fumarase_classII; cd01362 1358027004736 active site 1358027004737 tetramer interface [polypeptide binding]; other site 1358027004738 malate dehydrogenase; Provisional; Region: PRK13529 1358027004739 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1358027004740 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1358027004741 NAD(P) binding site [chemical binding]; other site 1358027004742 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1358027004743 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1358027004744 The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437 1358027004745 putative dimerization interface [polypeptide binding]; other site 1358027004746 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1358027004747 active site 1358027004748 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1358027004749 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1358027004750 putative NAD(P) binding site [chemical binding]; other site 1358027004751 putative substrate binding site [chemical binding]; other site 1358027004752 catalytic Zn binding site [ion binding]; other site 1358027004753 structural Zn binding site [ion binding]; other site 1358027004754 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1358027004755 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1358027004756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1358027004757 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1358027004758 active site 1358027004759 catalytic residues [active] 1358027004760 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1358027004761 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1358027004762 putative active site [active] 1358027004763 putative NTP binding site [chemical binding]; other site 1358027004764 putative nucleic acid binding site [nucleotide binding]; other site 1358027004765 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1358027004766 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1358027004767 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1358027004768 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1358027004769 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1358027004770 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1358027004771 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1358027004772 putative active site [active] 1358027004773 putative NTP binding site [chemical binding]; other site 1358027004774 putative nucleic acid binding site [nucleotide binding]; other site 1358027004775 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1358027004776 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1358027004777 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1358027004778 active site 1358027004779 homodimer interface [polypeptide binding]; other site 1358027004780 catalytic site [active] 1358027004781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027004782 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1358027004783 putative substrate translocation pore; other site 1358027004784 hypothetical protein; Provisional; Region: PRK07205 1358027004785 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1358027004786 active site 1358027004787 metal binding site [ion binding]; metal-binding site 1358027004788 Predicted membrane protein [Function unknown]; Region: COG1288 1358027004789 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1358027004790 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1358027004791 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1358027004792 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1358027004793 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1358027004794 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1358027004795 Predicted membrane protein [Function unknown]; Region: COG2855 1358027004796 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1358027004797 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1358027004798 dimer interface [polypeptide binding]; other site 1358027004799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1358027004800 catalytic residue [active] 1358027004801 Ferrochelatase; Region: Ferrochelatase; pfam00762 1358027004802 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1358027004803 C-terminal domain interface [polypeptide binding]; other site 1358027004804 active site 1358027004805 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1358027004806 active site 1358027004807 N-terminal domain interface [polypeptide binding]; other site 1358027004808 manganese transport protein MntH; Reviewed; Region: PRK00701 1358027004809 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1358027004810 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1358027004811 Integrase core domain; Region: rve; pfam00665 1358027004812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1358027004813 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1358027004814 TrkA-N domain; Region: TrkA_N; pfam02254 1358027004815 TrkA-C domain; Region: TrkA_C; pfam02080 1358027004816 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1358027004817 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1358027004818 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1358027004819 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1358027004820 dimer interface [polypeptide binding]; other site 1358027004821 FMN binding site [chemical binding]; other site 1358027004822 NADPH bind site [chemical binding]; other site 1358027004823 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1358027004824 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1358027004825 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1358027004826 DXD motif; other site 1358027004827 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1358027004828 PhoU domain; Region: PhoU; pfam01895 1358027004829 PhoU domain; Region: PhoU; pfam01895 1358027004830 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1358027004831 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1358027004832 Walker A/P-loop; other site 1358027004833 ATP binding site [chemical binding]; other site 1358027004834 Q-loop/lid; other site 1358027004835 ABC transporter signature motif; other site 1358027004836 Walker B; other site 1358027004837 D-loop; other site 1358027004838 H-loop/switch region; other site 1358027004839 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1358027004840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1358027004841 dimer interface [polypeptide binding]; other site 1358027004842 conserved gate region; other site 1358027004843 putative PBP binding loops; other site 1358027004844 ABC-ATPase subunit interface; other site 1358027004845 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1358027004846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1358027004847 dimer interface [polypeptide binding]; other site 1358027004848 conserved gate region; other site 1358027004849 putative PBP binding loops; other site 1358027004850 ABC-ATPase subunit interface; other site 1358027004851 PBP superfamily domain; Region: PBP_like_2; cl17296 1358027004852 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1358027004853 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1358027004854 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1358027004855 DNA binding site [nucleotide binding] 1358027004856 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1358027004857 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1358027004858 Walker A/P-loop; other site 1358027004859 ATP binding site [chemical binding]; other site 1358027004860 Q-loop/lid; other site 1358027004861 ABC transporter signature motif; other site 1358027004862 Walker B; other site 1358027004863 D-loop; other site 1358027004864 H-loop/switch region; other site 1358027004865 Cobalt transport protein; Region: CbiQ; cl00463 1358027004866 cobalt transport protein CbiM; Provisional; Region: PRK07331 1358027004867 cobalt transport protein CbiM; Provisional; Region: PRK11909 1358027004868 PDGLE domain; Region: PDGLE; cl07986 1358027004869 UreD urease accessory protein; Region: UreD; pfam01774 1358027004870 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1358027004871 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1358027004872 UreF; Region: UreF; pfam01730 1358027004873 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1358027004874 urease accessory protein UreE; Provisional; Region: PRK14112 1358027004875 dimer interface [polypeptide binding]; other site 1358027004876 catalytic residues [active] 1358027004877 urease, alpha subunit; Region: urease_alph; TIGR01792 1358027004878 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1358027004879 subunit interactions [polypeptide binding]; other site 1358027004880 active site 1358027004881 flap region; other site 1358027004882 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1358027004883 gamma-beta subunit interface [polypeptide binding]; other site 1358027004884 alpha-beta subunit interface [polypeptide binding]; other site 1358027004885 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1358027004886 alpha-gamma subunit interface [polypeptide binding]; other site 1358027004887 beta-gamma subunit interface [polypeptide binding]; other site 1358027004888 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 1358027004889 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1358027004890 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1358027004891 Coenzyme A binding pocket [chemical binding]; other site 1358027004892 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1358027004893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1358027004894 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1358027004895 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1358027004896 elongation factor P; Validated; Region: PRK00529 1358027004897 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1358027004898 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1358027004899 RNA binding site [nucleotide binding]; other site 1358027004900 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1358027004901 RNA binding site [nucleotide binding]; other site 1358027004902 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1358027004903 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1358027004904 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1358027004905 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1358027004906 putative active site [active] 1358027004907 putative NTP binding site [chemical binding]; other site 1358027004908 putative nucleic acid binding site [nucleotide binding]; other site 1358027004909 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1358027004910 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1358027004911 MucBP domain; Region: MucBP; pfam06458 1358027004912 MucBP domain; Region: MucBP; pfam06458 1358027004913 MucBP domain; Region: MucBP; pfam06458 1358027004914 MucBP domain; Region: MucBP; pfam06458 1358027004915 MucBP domain; Region: MucBP; pfam06458 1358027004916 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1358027004917 MucBP domain; Region: MucBP; pfam06458 1358027004918 MucBP domain; Region: MucBP; pfam06458 1358027004919 MucBP domain; Region: MucBP; pfam06458 1358027004920 MucBP domain; Region: MucBP; pfam06458 1358027004921 MucBP domain; Region: MucBP; pfam06458 1358027004922 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1358027004923 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1358027004924 Rib/alpha-like repeat; Region: Rib; cl07159 1358027004925 MucBP domain; Region: MucBP; pfam06458 1358027004926 MucBP domain; Region: MucBP; pfam06458 1358027004927 MucBP domain; Region: MucBP; pfam06458 1358027004928 MucBP domain; Region: MucBP; pfam06458 1358027004929 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1358027004930 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1358027004931 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 1358027004932 active site 1358027004933 Predicted membrane protein [Function unknown]; Region: COG2364 1358027004934 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1358027004935 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1358027004936 catalytic Zn binding site [ion binding]; other site 1358027004937 NAD(P) binding site [chemical binding]; other site 1358027004938 structural Zn binding site [ion binding]; other site 1358027004939 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1358027004940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1358027004941 Helix-turn-helix domain; Region: HTH_28; pfam13518 1358027004942 Integrase core domain; Region: rve; pfam00665 1358027004943 Integrase core domain; Region: rve_3; pfam13683 1358027004944 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1358027004945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027004946 putative substrate translocation pore; other site 1358027004947 hypothetical protein; Provisional; Region: PRK13690 1358027004948 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1358027004949 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1358027004950 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1358027004951 DNA binding site [nucleotide binding] 1358027004952 active site 1358027004953 Int/Topo IB signature motif; other site 1358027004954 TIGR02687 family protein; Region: TIGR02687 1358027004955 PglZ domain; Region: PglZ; pfam08665 1358027004956 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 1358027004957 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1358027004958 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1358027004959 Integrase core domain; Region: rve; pfam00665 1358027004960 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1358027004961 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1358027004962 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1358027004963 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 1358027004964 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 1358027004965 GMP synthase; Reviewed; Region: guaA; PRK00074 1358027004966 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1358027004967 AMP/PPi binding site [chemical binding]; other site 1358027004968 candidate oxyanion hole; other site 1358027004969 catalytic triad [active] 1358027004970 potential glutamine specificity residues [chemical binding]; other site 1358027004971 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1358027004972 ATP Binding subdomain [chemical binding]; other site 1358027004973 Ligand Binding sites [chemical binding]; other site 1358027004974 Dimerization subdomain; other site 1358027004975 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1358027004976 AAA domain; Region: AAA_14; pfam13173 1358027004977 pantothenate kinase; Provisional; Region: PRK05439 1358027004978 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1358027004979 ATP-binding site [chemical binding]; other site 1358027004980 CoA-binding site [chemical binding]; other site 1358027004981 Mg2+-binding site [ion binding]; other site 1358027004982 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1358027004983 Sulfatase; Region: Sulfatase; pfam00884 1358027004984 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1358027004985 EamA-like transporter family; Region: EamA; pfam00892 1358027004986 EamA-like transporter family; Region: EamA; cl17759 1358027004987 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1358027004988 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1358027004989 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1358027004990 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1358027004991 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1358027004992 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1358027004993 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1358027004994 Part of AAA domain; Region: AAA_19; pfam13245 1358027004995 Family description; Region: UvrD_C_2; pfam13538 1358027004996 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1358027004997 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1358027004998 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1358027004999 catalytic core [active] 1358027005000 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1358027005001 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1358027005002 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1358027005003 HflX GTPase family; Region: HflX; cd01878 1358027005004 G1 box; other site 1358027005005 GTP/Mg2+ binding site [chemical binding]; other site 1358027005006 Switch I region; other site 1358027005007 G2 box; other site 1358027005008 G3 box; other site 1358027005009 Switch II region; other site 1358027005010 G4 box; other site 1358027005011 G5 box; other site 1358027005012 Predicted membrane protein [Function unknown]; Region: COG2261 1358027005013 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1358027005014 D-lactate dehydrogenase; Validated; Region: PRK08605 1358027005015 homodimer interface [polypeptide binding]; other site 1358027005016 ligand binding site [chemical binding]; other site 1358027005017 NAD binding site [chemical binding]; other site 1358027005018 catalytic site [active] 1358027005019 Predicted membrane protein [Function unknown]; Region: COG1511 1358027005020 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1358027005021 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1358027005022 Predicted membrane protein [Function unknown]; Region: COG1511 1358027005023 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1358027005024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1358027005025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1358027005026 PspC domain; Region: PspC; pfam04024 1358027005027 DDE superfamily endonuclease; Region: DDE_5; cl17874 1358027005028 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1358027005029 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 1358027005030 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1358027005031 Integrase core domain; Region: rve; pfam00665 1358027005032 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1358027005033 metal binding site 2 [ion binding]; metal-binding site 1358027005034 putative DNA binding helix; other site 1358027005035 metal binding site 1 [ion binding]; metal-binding site 1358027005036 dimer interface [polypeptide binding]; other site 1358027005037 structural Zn2+ binding site [ion binding]; other site 1358027005038 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1358027005039 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1358027005040 active site 1358027005041 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 1358027005042 active site 1358027005043 Ap4A binding cleft/pocket [chemical binding]; other site 1358027005044 P4 phosphate binding site; other site 1358027005045 nudix motif; other site 1358027005046 putative P2/P3 phosphate binding site [ion binding]; other site 1358027005047 amino acid transporter; Region: 2A0306; TIGR00909 1358027005048 cation transport protein; Region: 2A0119; TIGR00898 1358027005049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027005050 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1358027005051 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1358027005052 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1358027005053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1358027005054 dimer interface [polypeptide binding]; other site 1358027005055 conserved gate region; other site 1358027005056 putative PBP binding loops; other site 1358027005057 ABC-ATPase subunit interface; other site 1358027005058 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1358027005059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1358027005060 dimer interface [polypeptide binding]; other site 1358027005061 conserved gate region; other site 1358027005062 putative PBP binding loops; other site 1358027005063 ABC-ATPase subunit interface; other site 1358027005064 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1358027005065 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1358027005066 Walker A/P-loop; other site 1358027005067 ATP binding site [chemical binding]; other site 1358027005068 Q-loop/lid; other site 1358027005069 ABC transporter signature motif; other site 1358027005070 Walker B; other site 1358027005071 D-loop; other site 1358027005072 H-loop/switch region; other site 1358027005073 TOBE domain; Region: TOBE_2; pfam08402 1358027005074 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1358027005075 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 1358027005076 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1358027005077 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1358027005078 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1358027005079 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1358027005080 dimerization interface [polypeptide binding]; other site 1358027005081 DPS ferroxidase diiron center [ion binding]; other site 1358027005082 ion pore; other site 1358027005083 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1358027005084 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1358027005085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1358027005086 motif II; other site 1358027005087 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1358027005088 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1358027005089 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1358027005090 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1358027005091 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1358027005092 active site 1358027005093 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1358027005094 homotetramer interface [polypeptide binding]; other site 1358027005095 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1358027005096 NAD binding site [chemical binding]; other site 1358027005097 homodimer interface [polypeptide binding]; other site 1358027005098 active site 1358027005099 hypothetical protein; Provisional; Region: PRK10621 1358027005100 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1358027005101 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1358027005102 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1358027005103 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1358027005104 Walker A/P-loop; other site 1358027005105 ATP binding site [chemical binding]; other site 1358027005106 Q-loop/lid; other site 1358027005107 ABC transporter signature motif; other site 1358027005108 Walker B; other site 1358027005109 D-loop; other site 1358027005110 H-loop/switch region; other site 1358027005111 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1358027005112 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1358027005113 Walker A/P-loop; other site 1358027005114 ATP binding site [chemical binding]; other site 1358027005115 Q-loop/lid; other site 1358027005116 ABC transporter signature motif; other site 1358027005117 Walker B; other site 1358027005118 D-loop; other site 1358027005119 H-loop/switch region; other site 1358027005120 Cobalt transport protein; Region: CbiQ; cl00463 1358027005121 Tic20-like protein; Region: Tic20; pfam09685 1358027005122 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1358027005123 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1358027005124 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1358027005125 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1358027005126 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1358027005127 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1358027005128 non-specific DNA binding site [nucleotide binding]; other site 1358027005129 salt bridge; other site 1358027005130 sequence-specific DNA binding site [nucleotide binding]; other site 1358027005131 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1358027005132 active site 1358027005133 metal binding site [ion binding]; metal-binding site 1358027005134 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1358027005135 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1358027005136 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1358027005137 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1358027005138 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 1358027005139 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1358027005140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027005141 putative substrate translocation pore; other site 1358027005142 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1358027005143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1358027005144 non-specific DNA binding site [nucleotide binding]; other site 1358027005145 salt bridge; other site 1358027005146 sequence-specific DNA binding site [nucleotide binding]; other site 1358027005147 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1358027005148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027005149 Walker A/P-loop; other site 1358027005150 ATP binding site [chemical binding]; other site 1358027005151 Q-loop/lid; other site 1358027005152 ABC transporter signature motif; other site 1358027005153 Walker B; other site 1358027005154 D-loop; other site 1358027005155 H-loop/switch region; other site 1358027005156 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1358027005157 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1358027005158 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1358027005159 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1358027005160 Ligand Binding Site [chemical binding]; other site 1358027005161 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1358027005162 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1358027005163 G1 box; other site 1358027005164 putative GEF interaction site [polypeptide binding]; other site 1358027005165 GTP/Mg2+ binding site [chemical binding]; other site 1358027005166 Switch I region; other site 1358027005167 G2 box; other site 1358027005168 G3 box; other site 1358027005169 Switch II region; other site 1358027005170 G4 box; other site 1358027005171 G5 box; other site 1358027005172 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1358027005173 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1358027005174 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1358027005175 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1358027005176 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1358027005177 nucleotide binding site [chemical binding]; other site 1358027005178 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1358027005179 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1358027005180 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1358027005181 nucleophilic elbow; other site 1358027005182 catalytic triad; other site 1358027005183 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1358027005184 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1358027005185 Spore germination protein; Region: Spore_permease; cl17796 1358027005186 putative phosphoketolase; Provisional; Region: PRK05261 1358027005187 XFP N-terminal domain; Region: XFP_N; pfam09364 1358027005188 XFP C-terminal domain; Region: XFP_C; pfam09363 1358027005189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1358027005190 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1358027005191 DNA-binding site [nucleotide binding]; DNA binding site 1358027005192 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1358027005193 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1358027005194 putative deacylase active site [active] 1358027005195 Peptidase family C69; Region: Peptidase_C69; pfam03577 1358027005196 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1358027005197 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1358027005198 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1358027005199 Walker A/P-loop; other site 1358027005200 ATP binding site [chemical binding]; other site 1358027005201 Q-loop/lid; other site 1358027005202 ABC transporter signature motif; other site 1358027005203 Walker B; other site 1358027005204 D-loop; other site 1358027005205 H-loop/switch region; other site 1358027005206 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1358027005207 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1358027005208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027005209 Walker A/P-loop; other site 1358027005210 ATP binding site [chemical binding]; other site 1358027005211 Q-loop/lid; other site 1358027005212 ABC transporter signature motif; other site 1358027005213 Walker B; other site 1358027005214 D-loop; other site 1358027005215 H-loop/switch region; other site 1358027005216 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1358027005217 D-lactate dehydrogenase; Validated; Region: PRK08605 1358027005218 homodimer interface [polypeptide binding]; other site 1358027005219 ligand binding site [chemical binding]; other site 1358027005220 NAD binding site [chemical binding]; other site 1358027005221 catalytic site [active] 1358027005222 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1358027005223 amphipathic channel; other site 1358027005224 Asn-Pro-Ala signature motifs; other site 1358027005225 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1358027005226 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1358027005227 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1358027005228 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1358027005229 B3/4 domain; Region: B3_4; pfam03483 1358027005230 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1358027005231 MarR family; Region: MarR; pfam01047 1358027005232 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1358027005233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1358027005234 active site 1358027005235 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1358027005236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027005237 Walker A/P-loop; other site 1358027005238 ATP binding site [chemical binding]; other site 1358027005239 Q-loop/lid; other site 1358027005240 ABC transporter signature motif; other site 1358027005241 Walker B; other site 1358027005242 D-loop; other site 1358027005243 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1358027005244 Domain of unknown function DUF21; Region: DUF21; pfam01595 1358027005245 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1358027005246 Transporter associated domain; Region: CorC_HlyC; smart01091 1358027005247 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 1358027005248 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1358027005249 dimer interface [polypeptide binding]; other site 1358027005250 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1358027005251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027005252 putative substrate translocation pore; other site 1358027005253 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1358027005254 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1358027005255 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1358027005256 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1358027005257 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1358027005258 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1358027005259 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1358027005260 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1358027005261 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1358027005262 HPr interaction site; other site 1358027005263 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1358027005264 active site 1358027005265 phosphorylation site [posttranslational modification] 1358027005266 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1358027005267 Ligand Binding Site [chemical binding]; other site 1358027005268 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1358027005269 Integrase core domain; Region: rve; pfam00665 1358027005270 Integrase core domain; Region: rve_3; pfam13683 1358027005271 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1358027005272 Helix-turn-helix domain; Region: HTH_28; pfam13518 1358027005273 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1358027005274 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1358027005275 putative DNA binding site [nucleotide binding]; other site 1358027005276 putative Zn2+ binding site [ion binding]; other site 1358027005277 AsnC family; Region: AsnC_trans_reg; pfam01037 1358027005278 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1358027005279 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1358027005280 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1358027005281 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1358027005282 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1358027005283 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1358027005284 DNA binding site [nucleotide binding] 1358027005285 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1358027005286 putative ligand binding site [chemical binding]; other site 1358027005287 putative dimerization interface [polypeptide binding]; other site 1358027005288 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1358027005289 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1358027005290 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1358027005291 galactokinase; Provisional; Region: PRK05322 1358027005292 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1358027005293 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1358027005294 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1358027005295 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 1358027005296 active site 1358027005297 catalytic triad [active] 1358027005298 oxyanion hole [active] 1358027005299 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1358027005300 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1358027005301 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1358027005302 substrate binding site [chemical binding]; other site 1358027005303 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1358027005304 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1358027005305 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1358027005306 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1358027005307 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1358027005308 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1358027005309 active site 1358027005310 catalytic tetrad [active] 1358027005311 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1358027005312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1358027005313 active site 1358027005314 phosphorylation site [posttranslational modification] 1358027005315 intermolecular recognition site; other site 1358027005316 dimerization interface [polypeptide binding]; other site 1358027005317 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1358027005318 DNA binding site [nucleotide binding] 1358027005319 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1358027005320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1358027005321 ATP binding site [chemical binding]; other site 1358027005322 Mg2+ binding site [ion binding]; other site 1358027005323 G-X-G motif; other site 1358027005324 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1358027005325 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1358027005326 Walker A/P-loop; other site 1358027005327 ATP binding site [chemical binding]; other site 1358027005328 Q-loop/lid; other site 1358027005329 ABC transporter signature motif; other site 1358027005330 Walker B; other site 1358027005331 D-loop; other site 1358027005332 H-loop/switch region; other site 1358027005333 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1358027005334 FtsX-like permease family; Region: FtsX; pfam02687 1358027005335 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1358027005336 proposed active site lysine [active] 1358027005337 conserved cys residue [active] 1358027005338 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1358027005339 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1358027005340 dimer interface [polypeptide binding]; other site 1358027005341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1358027005342 catalytic residue [active] 1358027005343 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1358027005344 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1358027005345 DNA binding residues [nucleotide binding] 1358027005346 dimer interface [polypeptide binding]; other site 1358027005347 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1358027005348 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1358027005349 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1358027005350 putative active site [active] 1358027005351 catalytic site [active] 1358027005352 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1358027005353 putative active site [active] 1358027005354 catalytic site [active] 1358027005355 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1358027005356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027005357 putative substrate translocation pore; other site 1358027005358 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1358027005359 putative ADP-ribose binding site [chemical binding]; other site 1358027005360 putative active site [active] 1358027005361 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1358027005362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1358027005363 non-specific DNA binding site [nucleotide binding]; other site 1358027005364 salt bridge; other site 1358027005365 sequence-specific DNA binding site [nucleotide binding]; other site 1358027005366 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1358027005367 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1358027005368 active site 1358027005369 Zn binding site [ion binding]; other site 1358027005370 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 1358027005371 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1358027005372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1358027005373 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1358027005374 Walker A motif; other site 1358027005375 ATP binding site [chemical binding]; other site 1358027005376 Walker B motif; other site 1358027005377 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1358027005378 active site 1358027005379 DNA binding site [nucleotide binding] 1358027005380 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1358027005381 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1358027005382 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1358027005383 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1358027005384 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 1358027005385 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1358027005386 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1358027005387 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1358027005388 Predicted membrane protein [Function unknown]; Region: COG4905 1358027005389 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1358027005390 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1358027005391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027005392 Walker A/P-loop; other site 1358027005393 ATP binding site [chemical binding]; other site 1358027005394 Q-loop/lid; other site 1358027005395 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1358027005396 ABC transporter signature motif; other site 1358027005397 Walker B; other site 1358027005398 D-loop; other site 1358027005399 ABC transporter; Region: ABC_tran_2; pfam12848 1358027005400 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1358027005401 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1358027005402 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1358027005403 non-specific DNA binding site [nucleotide binding]; other site 1358027005404 salt bridge; other site 1358027005405 sequence-specific DNA binding site [nucleotide binding]; other site 1358027005406 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1358027005407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1358027005408 non-specific DNA binding site [nucleotide binding]; other site 1358027005409 salt bridge; other site 1358027005410 sequence-specific DNA binding site [nucleotide binding]; other site 1358027005411 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 1358027005412 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1358027005413 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1358027005414 NlpC/P60 family; Region: NLPC_P60; pfam00877 1358027005415 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1358027005416 zinc binding site [ion binding]; other site 1358027005417 putative ligand binding site [chemical binding]; other site 1358027005418 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1358027005419 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1358027005420 TM-ABC transporter signature motif; other site 1358027005421 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1358027005422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1358027005423 Walker A/P-loop; other site 1358027005424 ATP binding site [chemical binding]; other site 1358027005425 Q-loop/lid; other site 1358027005426 ABC transporter signature motif; other site 1358027005427 Walker B; other site 1358027005428 D-loop; other site 1358027005429 H-loop/switch region; other site 1358027005430 Cadmium resistance transporter; Region: Cad; pfam03596 1358027005431 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1358027005432 dimerization interface [polypeptide binding]; other site 1358027005433 putative DNA binding site [nucleotide binding]; other site 1358027005434 putative Zn2+ binding site [ion binding]; other site 1358027005435 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1358027005436 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1358027005437 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1358027005438 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1358027005439 catalytic residues [active] 1358027005440 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1358027005441 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1358027005442 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1358027005443 active site 1358027005444 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1358027005445 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1358027005446 Cl binding site [ion binding]; other site 1358027005447 oligomer interface [polypeptide binding]; other site 1358027005448 xanthine permease; Region: pbuX; TIGR03173 1358027005449 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1358027005450 Predicted membrane protein [Function unknown]; Region: COG1288 1358027005451 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1358027005452 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1358027005453 catalytic core [active] 1358027005454 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1358027005455 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1358027005456 Sulfatase; Region: Sulfatase; pfam00884 1358027005457 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1358027005458 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1358027005459 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1358027005460 dimer interface [polypeptide binding]; other site 1358027005461 active site 1358027005462 metal binding site [ion binding]; metal-binding site 1358027005463 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1358027005464 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1358027005465 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1358027005466 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1358027005467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1358027005468 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1358027005469 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1358027005470 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1358027005471 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1358027005472 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1358027005473 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1358027005474 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1358027005475 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1358027005476 dimer interface [polypeptide binding]; other site 1358027005477 motif 1; other site 1358027005478 active site 1358027005479 motif 2; other site 1358027005480 motif 3; other site 1358027005481 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1358027005482 anticodon binding site; other site 1358027005483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027005484 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1358027005485 putative substrate translocation pore; other site 1358027005486 Uncharacterized conserved protein [Function unknown]; Region: COG4095 1358027005487 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1358027005488 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1358027005489 DNA binding site [nucleotide binding] 1358027005490 domain linker motif; other site 1358027005491 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1358027005492 dimerization interface [polypeptide binding]; other site 1358027005493 ligand binding site [chemical binding]; other site 1358027005494 sodium binding site [ion binding]; other site 1358027005495 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1358027005496 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1358027005497 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1358027005498 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1358027005499 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1358027005500 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1358027005501 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1358027005502 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1358027005503 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1358027005504 dimerization interface [polypeptide binding]; other site 1358027005505 putative DNA binding site [nucleotide binding]; other site 1358027005506 putative Zn2+ binding site [ion binding]; other site 1358027005507 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1358027005508 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1358027005509 Walker A/P-loop; other site 1358027005510 ATP binding site [chemical binding]; other site 1358027005511 Q-loop/lid; other site 1358027005512 ABC transporter signature motif; other site 1358027005513 Walker B; other site 1358027005514 D-loop; other site 1358027005515 H-loop/switch region; other site 1358027005516 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1358027005517 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1358027005518 FtsX-like permease family; Region: FtsX; pfam02687 1358027005519 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1358027005520 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1358027005521 Walker A/P-loop; other site 1358027005522 ATP binding site [chemical binding]; other site 1358027005523 Q-loop/lid; other site 1358027005524 ABC transporter signature motif; other site 1358027005525 Walker B; other site 1358027005526 D-loop; other site 1358027005527 H-loop/switch region; other site 1358027005528 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1358027005529 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1358027005530 FtsX-like permease family; Region: FtsX; pfam02687 1358027005531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1358027005532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1358027005533 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 1358027005534 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1358027005535 putative NAD(P) binding site [chemical binding]; other site 1358027005536 catalytic Zn binding site [ion binding]; other site 1358027005537 manganese transport protein MntH; Reviewed; Region: PRK00701 1358027005538 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1358027005539 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1358027005540 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1358027005541 active site 1358027005542 dimer interface [polypeptide binding]; other site 1358027005543 motif 1; other site 1358027005544 motif 2; other site 1358027005545 motif 3; other site 1358027005546 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1358027005547 anticodon binding site; other site 1358027005548 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1358027005549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027005550 putative substrate translocation pore; other site 1358027005551 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1358027005552 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1358027005553 amino acid transporter; Region: 2A0306; TIGR00909 1358027005554 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1358027005555 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1358027005556 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1358027005557 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1358027005558 substrate binding site [chemical binding]; other site 1358027005559 THF binding site; other site 1358027005560 zinc-binding site [ion binding]; other site 1358027005561 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 1358027005562 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 1358027005563 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 1358027005564 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1358027005565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1358027005566 Coenzyme A binding pocket [chemical binding]; other site 1358027005567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1358027005568 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1358027005569 NAD(P) binding site [chemical binding]; other site 1358027005570 active site 1358027005571 Predicted transcriptional regulators [Transcription]; Region: COG1733 1358027005572 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1358027005573 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1358027005574 dimer interface [polypeptide binding]; other site 1358027005575 FMN binding site [chemical binding]; other site 1358027005576 Predicted transcriptional regulators [Transcription]; Region: COG1733 1358027005577 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1358027005578 dimerization interface [polypeptide binding]; other site 1358027005579 putative DNA binding site [nucleotide binding]; other site 1358027005580 putative Zn2+ binding site [ion binding]; other site 1358027005581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1358027005582 putative substrate translocation pore; other site 1358027005583 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1358027005584 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1358027005585 trimer interface [polypeptide binding]; other site 1358027005586 active site 1358027005587 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1358027005588 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1358027005589 NAD(P) binding site [chemical binding]; other site 1358027005590 putative active site [active] 1358027005591 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1358027005592 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1358027005593 Zn binding site [ion binding]; other site 1358027005594 Predicted transcriptional regulator [Transcription]; Region: COG1959 1358027005595 Transcriptional regulator; Region: Rrf2; pfam02082 1358027005596 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1358027005597 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1358027005598 dimer interface [polypeptide binding]; other site 1358027005599 active site 1358027005600 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1358027005601 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1358027005602 putative dimer interface [polypeptide binding]; other site 1358027005603 putative anticodon binding site; other site 1358027005604 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1358027005605 homodimer interface [polypeptide binding]; other site 1358027005606 motif 1; other site 1358027005607 motif 2; other site 1358027005608 active site 1358027005609 motif 3; other site 1358027005610 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1358027005611 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1358027005612 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1358027005613 metal binding site [ion binding]; metal-binding site 1358027005614 active site 1358027005615 I-site; other site 1358027005616 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 1358027005617 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1358027005618 DXD motif; other site 1358027005619 EAL domain; Region: EAL; pfam00563 1358027005620 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1358027005621 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1358027005622 catalytic triad [active] 1358027005623 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1358027005624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1358027005625 NmrA-like family; Region: NmrA; pfam05368 1358027005626 NAD(P) binding site [chemical binding]; other site 1358027005627 active site 1358027005628 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1358027005629 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1358027005630 NAD binding site [chemical binding]; other site 1358027005631 substrate binding site [chemical binding]; other site 1358027005632 putative active site [active] 1358027005633 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1358027005634 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 1358027005635 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1358027005636 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1358027005637 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1358027005638 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1358027005639 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1358027005640 active site 1358027005641 catalytic tetrad [active] 1358027005642 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1358027005643 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1358027005644 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1358027005645 active site 1358027005646 homodimer interface [polypeptide binding]; other site 1358027005647 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1358027005648 Predicted secreted protein [Function unknown]; Region: COG4086 1358027005649 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1358027005650 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1358027005651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1358027005652 homodimer interface [polypeptide binding]; other site 1358027005653 catalytic residue [active] 1358027005654 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1358027005655 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1358027005656 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1358027005657 NAD binding site [chemical binding]; other site 1358027005658 dimer interface [polypeptide binding]; other site 1358027005659 substrate binding site [chemical binding]; other site 1358027005660 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1358027005661 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1358027005662 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1358027005663 nucleophilic elbow; other site 1358027005664 catalytic triad; other site 1358027005665 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1358027005666 active site 1358027005667 substrate binding site [chemical binding]; other site 1358027005668 trimer interface [polypeptide binding]; other site 1358027005669 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1358027005670 CoA binding site [chemical binding]; other site 1358027005671 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1358027005672 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1358027005673 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1358027005674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1358027005675 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1358027005676 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1358027005677 FAD binding pocket [chemical binding]; other site 1358027005678 conserved FAD binding motif [chemical binding]; other site 1358027005679 phosphate binding motif [ion binding]; other site 1358027005680 beta-alpha-beta structure motif; other site 1358027005681 NAD binding pocket [chemical binding]; other site 1358027005682 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1358027005683 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1358027005684 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1358027005685 HAMP domain; Region: HAMP; pfam00672 1358027005686 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1358027005687 dimer interface [polypeptide binding]; other site 1358027005688 phosphorylation site [posttranslational modification] 1358027005689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1358027005690 ATP binding site [chemical binding]; other site 1358027005691 Mg2+ binding site [ion binding]; other site 1358027005692 G-X-G motif; other site 1358027005693 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1358027005694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1358027005695 active site 1358027005696 phosphorylation site [posttranslational modification] 1358027005697 intermolecular recognition site; other site 1358027005698 dimerization interface [polypeptide binding]; other site 1358027005699 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1358027005700 DNA binding site [nucleotide binding] 1358027005701 Predicted permeases [General function prediction only]; Region: COG0679 1358027005702 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1358027005703 RibD C-terminal domain; Region: RibD_C; cl17279 1358027005704 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 1358027005705 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1358027005706 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1358027005707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1358027005708 active site 1358027005709 phosphorylation site [posttranslational modification] 1358027005710 intermolecular recognition site; other site 1358027005711 dimerization interface [polypeptide binding]; other site 1358027005712 LytTr DNA-binding domain; Region: LytTR; pfam04397 1358027005713 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1358027005714 putative active site [active] 1358027005715 RelB antitoxin; Region: RelB; cl01171 1358027005716 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1358027005717 putative deacylase active site [active] 1358027005718 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1358027005719 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1358027005720 active site 1358027005721 Beta-lactamase; Region: Beta-lactamase; pfam00144 1358027005722 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1358027005723 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1358027005724 active site 1358027005725 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1358027005726 MgtC family; Region: MgtC; pfam02308 1358027005727 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1358027005728 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1358027005729 AzlC protein; Region: AzlC; cl00570 1358027005730 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1358027005731 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1358027005732 active site 1358027005733 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1358027005734 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1358027005735 active site 1358027005736 catalytic tetrad [active] 1358027005737 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1358027005738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1358027005739 Coenzyme A binding pocket [chemical binding]; other site 1358027005740 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1358027005741 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1358027005742 Catalytic site [active] 1358027005743 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1358027005744 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 1358027005745 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1358027005746 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1358027005747 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1358027005748 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1358027005749 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1358027005750 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1358027005751 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1358027005752 active site 1358027005753 dimer interface [polypeptide binding]; other site 1358027005754 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1358027005755 Ligand Binding Site [chemical binding]; other site 1358027005756 Molecular Tunnel; other site 1358027005757 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1358027005758 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1358027005759 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1358027005760 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1358027005761 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1358027005762 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1358027005763 G1 box; other site 1358027005764 GTP/Mg2+ binding site [chemical binding]; other site 1358027005765 Switch I region; other site 1358027005766 G2 box; other site 1358027005767 Switch II region; other site 1358027005768 G3 box; other site 1358027005769 G4 box; other site 1358027005770 G5 box; other site 1358027005771 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1358027005772 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1358027005773 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1358027005774 G-X-X-G motif; other site 1358027005775 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1358027005776 RxxxH motif; other site 1358027005777 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1358027005778 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1358027005779 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1358027005780 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399