-- dump date 20140619_124637 -- class Genbank::misc_feature -- table misc_feature_note -- id note 568703000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 568703000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 568703000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703000004 Walker A motif; other site 568703000005 ATP binding site [chemical binding]; other site 568703000006 Walker B motif; other site 568703000007 arginine finger; other site 568703000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 568703000009 DnaA box-binding interface [nucleotide binding]; other site 568703000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 568703000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 568703000012 putative DNA binding surface [nucleotide binding]; other site 568703000013 dimer interface [polypeptide binding]; other site 568703000014 beta-clamp/clamp loader binding surface; other site 568703000015 beta-clamp/translesion DNA polymerase binding surface; other site 568703000016 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 568703000017 recombination protein F; Reviewed; Region: recF; PRK00064 568703000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 568703000019 Walker A/P-loop; other site 568703000020 ATP binding site [chemical binding]; other site 568703000021 Q-loop/lid; other site 568703000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703000023 ABC transporter signature motif; other site 568703000024 Walker B; other site 568703000025 D-loop; other site 568703000026 H-loop/switch region; other site 568703000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 568703000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703000029 Mg2+ binding site [ion binding]; other site 568703000030 G-X-G motif; other site 568703000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 568703000032 anchoring element; other site 568703000033 dimer interface [polypeptide binding]; other site 568703000034 ATP binding site [chemical binding]; other site 568703000035 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 568703000036 active site 568703000037 metal binding site [ion binding]; metal-binding site 568703000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 568703000039 DNA gyrase subunit A; Validated; Region: PRK05560 568703000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 568703000041 CAP-like domain; other site 568703000042 active site 568703000043 primary dimer interface [polypeptide binding]; other site 568703000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703000050 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 568703000051 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 568703000052 dimer interface [polypeptide binding]; other site 568703000053 ssDNA binding site [nucleotide binding]; other site 568703000054 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703000055 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 568703000056 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 568703000057 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 568703000058 dimer interface [polypeptide binding]; other site 568703000059 ssDNA binding site [nucleotide binding]; other site 568703000060 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703000061 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 568703000062 intracellular protease, PfpI family; Region: PfpI; TIGR01382 568703000063 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 568703000064 proposed catalytic triad [active] 568703000065 conserved cys residue [active] 568703000066 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 568703000067 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 568703000068 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 568703000069 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 568703000070 Helix-turn-helix domain; Region: HTH_38; pfam13936 568703000071 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 568703000072 Integrase core domain; Region: rve; pfam00665 568703000073 CAAX protease self-immunity; Region: Abi; pfam02517 568703000074 Transposase domain (DUF772); Region: DUF772; pfam05598 568703000075 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703000076 CAAX protease self-immunity; Region: Abi; pfam02517 568703000077 ABC-2 type transporter; Region: ABC2_membrane; cl17235 568703000078 Transposase domain (DUF772); Region: DUF772; pfam05598 568703000079 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703000080 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703000081 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703000082 Walker A/P-loop; other site 568703000083 ATP binding site [chemical binding]; other site 568703000084 Q-loop/lid; other site 568703000085 ABC transporter signature motif; other site 568703000086 Walker B; other site 568703000087 D-loop; other site 568703000088 H-loop/switch region; other site 568703000089 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 568703000090 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 568703000091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 568703000092 CHAP domain; Region: CHAP; pfam05257 568703000093 Surface antigen [General function prediction only]; Region: COG3942 568703000094 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568703000095 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568703000096 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 568703000097 FtsX-like permease family; Region: FtsX; pfam02687 568703000098 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703000099 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568703000100 Walker A/P-loop; other site 568703000101 ATP binding site [chemical binding]; other site 568703000102 Q-loop/lid; other site 568703000103 ABC transporter signature motif; other site 568703000104 Walker B; other site 568703000105 D-loop; other site 568703000106 H-loop/switch region; other site 568703000107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703000108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703000109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 568703000110 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703000111 active site 568703000112 motif I; other site 568703000113 motif II; other site 568703000114 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 568703000115 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568703000116 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 568703000117 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 568703000118 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 568703000119 active site 568703000120 substrate binding site [chemical binding]; other site 568703000121 trimer interface [polypeptide binding]; other site 568703000122 CoA binding site [chemical binding]; other site 568703000123 Peptidase family C69; Region: Peptidase_C69; pfam03577 568703000124 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 568703000125 active site 568703000126 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 568703000127 Predicted membrane protein [Function unknown]; Region: COG4392 568703000128 beta-D-glucuronidase; Provisional; Region: PRK10150 568703000129 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 568703000130 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 568703000131 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 568703000132 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 568703000133 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 568703000134 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 568703000135 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 568703000136 active site 568703000137 intersubunit interface [polypeptide binding]; other site 568703000138 catalytic residue [active] 568703000139 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 568703000140 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568703000141 substrate binding site [chemical binding]; other site 568703000142 ATP binding site [chemical binding]; other site 568703000143 Glucuronate isomerase; Region: UxaC; cl00829 568703000144 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 568703000145 Glucuronate isomerase; Region: UxaC; cl00829 568703000146 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 568703000147 mannonate dehydratase; Region: uxuA; TIGR00695 568703000148 mannonate dehydratase; Provisional; Region: PRK03906 568703000149 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 568703000150 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 568703000151 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 568703000152 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 568703000153 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703000154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000155 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568703000156 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703000157 DNA-binding site [nucleotide binding]; DNA binding site 568703000158 FCD domain; Region: FCD; pfam07729 568703000159 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568703000160 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 568703000161 substrate binding site [chemical binding]; other site 568703000162 ATP binding site [chemical binding]; other site 568703000163 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 568703000164 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 568703000165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000166 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703000167 putative substrate translocation pore; other site 568703000168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000169 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 568703000170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703000171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703000172 MMPL family; Region: MMPL; pfam03176 568703000173 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 568703000174 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703000175 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703000176 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568703000177 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 568703000178 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568703000179 active site 568703000180 putative diguanylate cyclase; Provisional; Region: PRK09776 568703000181 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 568703000182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703000183 dimer interface [polypeptide binding]; other site 568703000184 conserved gate region; other site 568703000185 putative PBP binding loops; other site 568703000186 ABC-ATPase subunit interface; other site 568703000187 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 568703000188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703000189 dimer interface [polypeptide binding]; other site 568703000190 conserved gate region; other site 568703000191 putative PBP binding loops; other site 568703000192 ABC-ATPase subunit interface; other site 568703000193 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 568703000194 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 568703000195 Walker A/P-loop; other site 568703000196 ATP binding site [chemical binding]; other site 568703000197 Q-loop/lid; other site 568703000198 ABC transporter signature motif; other site 568703000199 Walker B; other site 568703000200 D-loop; other site 568703000201 H-loop/switch region; other site 568703000202 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 568703000203 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 568703000204 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 568703000205 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 568703000206 DNA binding residues [nucleotide binding] 568703000207 dimer interface [polypeptide binding]; other site 568703000208 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 568703000209 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703000210 Soluble P-type ATPase [General function prediction only]; Region: COG4087 568703000211 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 568703000212 metal-binding site [ion binding] 568703000213 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 568703000214 dinuclear metal binding motif [ion binding]; other site 568703000215 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 568703000216 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 568703000217 ligand binding site [chemical binding]; other site 568703000218 flexible hinge region; other site 568703000219 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 568703000220 putative switch regulator; other site 568703000221 non-specific DNA interactions [nucleotide binding]; other site 568703000222 DNA binding site [nucleotide binding] 568703000223 sequence specific DNA binding site [nucleotide binding]; other site 568703000224 putative cAMP binding site [chemical binding]; other site 568703000225 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703000226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703000227 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 568703000228 CAAX protease self-immunity; Region: Abi; pfam02517 568703000229 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 568703000230 active site 568703000231 P-loop; other site 568703000232 phosphorylation site [posttranslational modification] 568703000233 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 568703000234 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 568703000235 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703000236 active site 568703000237 phosphorylation site [posttranslational modification] 568703000238 alpha-mannosidase; Provisional; Region: PRK09819 568703000239 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 568703000240 active site 568703000241 metal binding site [ion binding]; metal-binding site 568703000242 catalytic site [active] 568703000243 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 568703000244 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568703000245 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568703000246 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568703000247 putative active site [active] 568703000248 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 568703000249 beta-galactosidase; Region: BGL; TIGR03356 568703000250 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 568703000251 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568703000252 nucleotide binding site [chemical binding]; other site 568703000253 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 568703000254 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 568703000255 substrate binding site [chemical binding]; other site 568703000256 active site 568703000257 catalytic residues [active] 568703000258 heterodimer interface [polypeptide binding]; other site 568703000259 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 568703000260 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 568703000261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703000262 catalytic residue [active] 568703000263 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 568703000264 active site 568703000265 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 568703000266 active site 568703000267 ribulose/triose binding site [chemical binding]; other site 568703000268 phosphate binding site [ion binding]; other site 568703000269 substrate (anthranilate) binding pocket [chemical binding]; other site 568703000270 product (indole) binding pocket [chemical binding]; other site 568703000271 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 568703000272 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 568703000273 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 568703000274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000275 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703000276 putative substrate translocation pore; other site 568703000277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000278 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703000279 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703000280 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 568703000281 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 568703000282 dihydrodipicolinate reductase; Provisional; Region: PRK00048 568703000283 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 568703000284 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 568703000285 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 568703000286 dihydrodipicolinate synthase; Region: dapA; TIGR00674 568703000287 dimer interface [polypeptide binding]; other site 568703000288 active site 568703000289 catalytic residue [active] 568703000290 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 568703000291 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 568703000292 metal binding site [ion binding]; metal-binding site 568703000293 putative dimer interface [polypeptide binding]; other site 568703000294 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 568703000295 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 568703000296 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 568703000297 putative trimer interface [polypeptide binding]; other site 568703000298 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 568703000299 putative CoA binding site [chemical binding]; other site 568703000300 putative trimer interface [polypeptide binding]; other site 568703000301 putative CoA binding site [chemical binding]; other site 568703000302 diaminopimelate decarboxylase; Region: lysA; TIGR01048 568703000303 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 568703000304 active site 568703000305 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568703000306 substrate binding site [chemical binding]; other site 568703000307 catalytic residues [active] 568703000308 dimer interface [polypeptide binding]; other site 568703000309 aspartate kinase; Reviewed; Region: PRK09034 568703000310 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 568703000311 putative catalytic residues [active] 568703000312 putative nucleotide binding site [chemical binding]; other site 568703000313 putative aspartate binding site [chemical binding]; other site 568703000314 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 568703000315 allosteric regulatory residue; other site 568703000316 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 568703000317 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 568703000318 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 568703000319 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 568703000320 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 568703000321 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 568703000322 Peptidase M15; Region: Peptidase_M15_3; cl01194 568703000323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703000324 non-specific DNA binding site [nucleotide binding]; other site 568703000325 salt bridge; other site 568703000326 sequence-specific DNA binding site [nucleotide binding]; other site 568703000327 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 568703000328 nudix motif; other site 568703000329 EamA-like transporter family; Region: EamA; pfam00892 568703000330 xanthine dehydrogenase; Region: PLN02906 568703000331 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 568703000332 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 568703000333 DHH family; Region: DHH; pfam01368 568703000334 DHHA1 domain; Region: DHHA1; pfam02272 568703000335 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 568703000336 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 568703000337 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 568703000338 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 568703000339 replicative DNA helicase; Provisional; Region: PRK05748 568703000340 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 568703000341 Walker A motif; other site 568703000342 ATP binding site [chemical binding]; other site 568703000343 Walker B motif; other site 568703000344 DNA binding loops [nucleotide binding] 568703000345 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 568703000346 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 568703000347 active site turn [active] 568703000348 phosphorylation site [posttranslational modification] 568703000349 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568703000350 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 568703000351 HPr interaction site; other site 568703000352 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568703000353 active site 568703000354 phosphorylation site [posttranslational modification] 568703000355 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 568703000356 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 568703000357 putative active site [active] 568703000358 Uncharacterized conserved protein [Function unknown]; Region: COG3589 568703000359 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 568703000360 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568703000361 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568703000362 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568703000363 putative active site [active] 568703000364 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703000365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703000366 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 568703000367 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703000368 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568703000369 Walker A/P-loop; other site 568703000370 ATP binding site [chemical binding]; other site 568703000371 Q-loop/lid; other site 568703000372 ABC transporter signature motif; other site 568703000373 Walker B; other site 568703000374 D-loop; other site 568703000375 H-loop/switch region; other site 568703000376 FtsX-like permease family; Region: FtsX; pfam02687 568703000377 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568703000378 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 568703000379 FtsX-like permease family; Region: FtsX; pfam02687 568703000380 Amidohydrolase; Region: Amidohydro_2; pfam04909 568703000381 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 568703000382 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 568703000383 GDP-binding site [chemical binding]; other site 568703000384 ACT binding site; other site 568703000385 IMP binding site; other site 568703000386 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 568703000387 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703000388 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 568703000389 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568703000390 dimerization interface [polypeptide binding]; other site 568703000391 putative DNA binding site [nucleotide binding]; other site 568703000392 putative Zn2+ binding site [ion binding]; other site 568703000393 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703000394 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 568703000395 ATP cone domain; Region: ATP-cone; pfam03477 568703000396 Class III ribonucleotide reductase; Region: RNR_III; cd01675 568703000397 effector binding site; other site 568703000398 active site 568703000399 Zn binding site [ion binding]; other site 568703000400 glycine loop; other site 568703000401 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703000402 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703000403 non-specific DNA binding site [nucleotide binding]; other site 568703000404 salt bridge; other site 568703000405 sequence-specific DNA binding site [nucleotide binding]; other site 568703000406 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 568703000407 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 568703000408 Transposase; Region: DEDD_Tnp_IS110; pfam01548 568703000409 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 568703000410 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 568703000411 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 568703000412 active site 568703000413 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 568703000414 putative dimer interface [polypeptide binding]; other site 568703000415 catalytic triad [active] 568703000416 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 568703000417 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 568703000418 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568703000419 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568703000420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000421 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568703000422 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703000423 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703000424 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703000425 HAMP domain; Region: HAMP; pfam00672 568703000426 dimerization interface [polypeptide binding]; other site 568703000427 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703000428 dimer interface [polypeptide binding]; other site 568703000429 phosphorylation site [posttranslational modification] 568703000430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703000431 ATP binding site [chemical binding]; other site 568703000432 Mg2+ binding site [ion binding]; other site 568703000433 G-X-G motif; other site 568703000434 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703000435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703000436 active site 568703000437 phosphorylation site [posttranslational modification] 568703000438 intermolecular recognition site; other site 568703000439 dimerization interface [polypeptide binding]; other site 568703000440 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703000441 DNA binding site [nucleotide binding] 568703000442 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 568703000443 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 568703000444 DNA binding site [nucleotide binding] 568703000445 active site 568703000446 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 568703000447 D-lactate dehydrogenase; Validated; Region: PRK08605 568703000448 homodimer interface [polypeptide binding]; other site 568703000449 ligand binding site [chemical binding]; other site 568703000450 NAD binding site [chemical binding]; other site 568703000451 catalytic site [active] 568703000452 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 568703000453 active site 568703000454 P-loop; other site 568703000455 phosphorylation site [posttranslational modification] 568703000456 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 568703000457 active site 568703000458 methionine cluster; other site 568703000459 phosphorylation site [posttranslational modification] 568703000460 metal binding site [ion binding]; metal-binding site 568703000461 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 568703000462 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 568703000463 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 568703000464 beta-galactosidase; Region: BGL; TIGR03356 568703000465 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703000466 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703000467 DNA-binding site [nucleotide binding]; DNA binding site 568703000468 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 568703000469 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 568703000470 Protein of unknown function (DUF1516); Region: DUF1516; pfam07457 568703000471 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 568703000472 DsrE/DsrF-like family; Region: DrsE; cl00672 568703000473 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703000474 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568703000475 Walker A/P-loop; other site 568703000476 ATP binding site [chemical binding]; other site 568703000477 Q-loop/lid; other site 568703000478 ABC transporter signature motif; other site 568703000479 Walker B; other site 568703000480 D-loop; other site 568703000481 H-loop/switch region; other site 568703000482 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 568703000483 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 568703000484 substrate binding pocket [chemical binding]; other site 568703000485 membrane-bound complex binding site; other site 568703000486 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568703000487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703000488 dimer interface [polypeptide binding]; other site 568703000489 conserved gate region; other site 568703000490 putative PBP binding loops; other site 568703000491 ABC-ATPase subunit interface; other site 568703000492 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 568703000493 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 568703000494 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703000495 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568703000496 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 568703000497 active site residue [active] 568703000498 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 568703000499 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703000500 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703000501 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703000502 dimerization interface [polypeptide binding]; other site 568703000503 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 568703000504 Zn binding site [ion binding]; other site 568703000505 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 568703000506 Zn binding site [ion binding]; other site 568703000507 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568703000508 WxL domain surface cell wall-binding; Region: WxL; pfam13731 568703000509 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 568703000510 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 568703000511 Mga helix-turn-helix domain; Region: Mga; pfam05043 568703000512 Protein of unknown function (DUF805); Region: DUF805; pfam05656 568703000513 Protein of unknown function (DUF805); Region: DUF805; pfam05656 568703000514 recombination factor protein RarA; Reviewed; Region: PRK13342 568703000515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703000516 Walker A motif; other site 568703000517 ATP binding site [chemical binding]; other site 568703000518 Walker B motif; other site 568703000519 arginine finger; other site 568703000520 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 568703000521 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 568703000522 propionate/acetate kinase; Provisional; Region: PRK12379 568703000523 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703000524 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 568703000525 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568703000526 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 568703000527 FGGY family of carbohydrate kinases; Region: FGGY; cd00366 568703000528 N- and C-terminal domain interface [polypeptide binding]; other site 568703000529 active site 568703000530 MgATP binding site [chemical binding]; other site 568703000531 catalytic site [active] 568703000532 metal binding site [ion binding]; metal-binding site 568703000533 carbohydrate binding site [chemical binding]; other site 568703000534 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 568703000535 intersubunit interface [polypeptide binding]; other site 568703000536 active site 568703000537 zinc binding site [ion binding]; other site 568703000538 Na+ binding site [ion binding]; other site 568703000539 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 568703000540 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 568703000541 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568703000542 active site 568703000543 metal binding site [ion binding]; metal-binding site 568703000544 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568703000545 endonuclease III; Region: ENDO3c; smart00478 568703000546 minor groove reading motif; other site 568703000547 helix-hairpin-helix signature motif; other site 568703000548 substrate binding pocket [chemical binding]; other site 568703000549 active site 568703000550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000551 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703000552 putative substrate translocation pore; other site 568703000553 putative phosphoketolase; Provisional; Region: PRK05261 568703000554 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 568703000555 TPP-binding site; other site 568703000556 XFP C-terminal domain; Region: XFP_C; pfam09363 568703000557 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568703000558 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568703000559 peptide binding site [polypeptide binding]; other site 568703000560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703000561 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703000562 Walker A/P-loop; other site 568703000563 ATP binding site [chemical binding]; other site 568703000564 Q-loop/lid; other site 568703000565 ABC transporter signature motif; other site 568703000566 Walker B; other site 568703000567 D-loop; other site 568703000568 H-loop/switch region; other site 568703000569 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 568703000570 nudix motif; other site 568703000571 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703000572 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568703000573 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 568703000574 Walker A/P-loop; other site 568703000575 ATP binding site [chemical binding]; other site 568703000576 Q-loop/lid; other site 568703000577 ABC transporter signature motif; other site 568703000578 Walker B; other site 568703000579 D-loop; other site 568703000580 H-loop/switch region; other site 568703000581 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703000582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703000583 non-specific DNA binding site [nucleotide binding]; other site 568703000584 salt bridge; other site 568703000585 sequence-specific DNA binding site [nucleotide binding]; other site 568703000586 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 568703000587 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 568703000588 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 568703000589 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703000590 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568703000591 Repair protein; Region: Repair_PSII; pfam04536 568703000592 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568703000593 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 568703000594 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 568703000595 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 568703000596 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 568703000597 putative ligand binding site [chemical binding]; other site 568703000598 putative NAD binding site [chemical binding]; other site 568703000599 catalytic site [active] 568703000600 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 568703000601 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 568703000602 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 568703000603 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 568703000604 Asp23 family; Region: Asp23; pfam03780 568703000605 Asp23 family; Region: Asp23; pfam03780 568703000606 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 568703000607 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703000608 motif II; other site 568703000609 Protein of unknown function (DUF969); Region: DUF969; pfam06149 568703000610 Predicted membrane protein [Function unknown]; Region: COG3817 568703000611 Protein of unknown function (DUF979); Region: DUF979; pfam06166 568703000612 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 568703000613 putative substrate binding pocket [chemical binding]; other site 568703000614 AC domain interface; other site 568703000615 catalytic triad [active] 568703000616 AB domain interface; other site 568703000617 interchain disulfide; other site 568703000618 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 568703000619 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 568703000620 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 568703000621 catalytic triad [active] 568703000622 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 568703000623 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 568703000624 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 568703000625 ParB-like nuclease domain; Region: ParBc; pfam02195 568703000626 KorB domain; Region: KorB; pfam08535 568703000627 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 568703000628 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 568703000629 P-loop; other site 568703000630 Magnesium ion binding site [ion binding]; other site 568703000631 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 568703000632 Magnesium ion binding site [ion binding]; other site 568703000633 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 568703000634 ParB-like nuclease domain; Region: ParB; smart00470 568703000635 KorB domain; Region: KorB; pfam08535 568703000636 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 568703000637 GTP-binding protein YchF; Reviewed; Region: PRK09601 568703000638 YchF GTPase; Region: YchF; cd01900 568703000639 G1 box; other site 568703000640 GTP/Mg2+ binding site [chemical binding]; other site 568703000641 Switch I region; other site 568703000642 G2 box; other site 568703000643 Switch II region; other site 568703000644 G3 box; other site 568703000645 G4 box; other site 568703000646 G5 box; other site 568703000647 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 568703000648 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 568703000649 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 568703000650 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 568703000651 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 568703000652 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 568703000653 active site 568703000654 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703000655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703000656 active site 568703000657 phosphorylation site [posttranslational modification] 568703000658 intermolecular recognition site; other site 568703000659 dimerization interface [polypeptide binding]; other site 568703000660 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703000661 DNA binding site [nucleotide binding] 568703000662 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703000663 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 568703000664 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703000665 dimer interface [polypeptide binding]; other site 568703000666 phosphorylation site [posttranslational modification] 568703000667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703000668 ATP binding site [chemical binding]; other site 568703000669 Mg2+ binding site [ion binding]; other site 568703000670 G-X-G motif; other site 568703000671 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 568703000672 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 568703000673 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 568703000674 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 568703000675 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 568703000676 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 568703000677 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 568703000678 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568703000679 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568703000680 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568703000681 aspartate racemase; Region: asp_race; TIGR00035 568703000682 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 568703000683 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703000684 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703000685 active site 568703000686 catalytic tetrad [active] 568703000687 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703000688 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 568703000689 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568703000690 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 568703000691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000692 putative substrate translocation pore; other site 568703000693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000694 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 568703000695 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 568703000696 tetrameric interface [polypeptide binding]; other site 568703000697 NAD binding site [chemical binding]; other site 568703000698 catalytic residues [active] 568703000699 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 568703000700 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568703000701 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 568703000702 substrate binding site [chemical binding]; other site 568703000703 ATP binding site [chemical binding]; other site 568703000704 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 568703000705 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568703000706 PYR/PP interface [polypeptide binding]; other site 568703000707 dimer interface [polypeptide binding]; other site 568703000708 TPP binding site [chemical binding]; other site 568703000709 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568703000710 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 568703000711 TPP-binding site; other site 568703000712 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568703000713 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568703000714 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568703000715 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568703000716 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568703000717 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 568703000718 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 568703000719 intersubunit interface [polypeptide binding]; other site 568703000720 active site 568703000721 zinc binding site [ion binding]; other site 568703000722 Na+ binding site [ion binding]; other site 568703000723 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 568703000724 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 568703000725 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 568703000726 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568703000727 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568703000728 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568703000729 putative active site [active] 568703000730 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568703000731 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 568703000732 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 568703000733 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 568703000734 N- and C-terminal domain interface [polypeptide binding]; other site 568703000735 active site 568703000736 catalytic site [active] 568703000737 metal binding site [ion binding]; metal-binding site 568703000738 carbohydrate binding site [chemical binding]; other site 568703000739 ATP binding site [chemical binding]; other site 568703000740 fructuronate transporter; Provisional; Region: PRK10034; cl15264 568703000741 Citrate transporter; Region: CitMHS; pfam03600 568703000742 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568703000743 active site 568703000744 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 568703000745 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 568703000746 Probable Catalytic site; other site 568703000747 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 568703000748 Probable Catalytic site; other site 568703000749 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 568703000750 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 568703000751 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568703000752 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 568703000753 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 568703000754 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 568703000755 putative PBP binding regions; other site 568703000756 ABC-ATPase subunit interface; other site 568703000757 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 568703000758 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568703000759 active site 568703000760 metal binding site [ion binding]; metal-binding site 568703000761 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 568703000762 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568703000763 oligoendopeptidase F; Region: pepF; TIGR00181 568703000764 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 568703000765 active site 568703000766 Zn binding site [ion binding]; other site 568703000767 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 568703000768 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 568703000769 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703000770 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 568703000771 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568703000772 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 568703000773 active site 568703000774 Protein of unknown function (DUF975); Region: DUF975; cl10504 568703000775 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 568703000776 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 568703000777 Catalytic site [active] 568703000778 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 568703000779 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 568703000780 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 568703000781 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703000782 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703000783 ABC transporter; Region: ABC_tran_2; pfam12848 568703000784 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703000785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703000786 S-adenosylmethionine binding site [chemical binding]; other site 568703000787 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568703000788 Uncharacterized conserved protein [Function unknown]; Region: COG2966 568703000789 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 568703000790 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 568703000791 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568703000792 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 568703000793 putative ligand binding site [chemical binding]; other site 568703000794 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568703000795 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568703000796 TM-ABC transporter signature motif; other site 568703000797 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568703000798 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568703000799 TM-ABC transporter signature motif; other site 568703000800 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568703000801 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568703000802 Walker A/P-loop; other site 568703000803 ATP binding site [chemical binding]; other site 568703000804 Q-loop/lid; other site 568703000805 ABC transporter signature motif; other site 568703000806 Walker B; other site 568703000807 D-loop; other site 568703000808 H-loop/switch region; other site 568703000809 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568703000810 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568703000811 Walker A/P-loop; other site 568703000812 ATP binding site [chemical binding]; other site 568703000813 Q-loop/lid; other site 568703000814 ABC transporter signature motif; other site 568703000815 Walker B; other site 568703000816 D-loop; other site 568703000817 H-loop/switch region; other site 568703000818 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 568703000819 metal binding site [ion binding]; metal-binding site 568703000820 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 568703000821 PGAP1-like protein; Region: PGAP1; pfam07819 568703000822 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 568703000823 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 568703000824 intersubunit interface [polypeptide binding]; other site 568703000825 active site 568703000826 catalytic residue [active] 568703000827 phosphopentomutase; Provisional; Region: PRK05362 568703000828 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 568703000829 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 568703000830 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 568703000831 NlpC/P60 family; Region: NLPC_P60; pfam00877 568703000832 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 568703000833 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703000834 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 568703000835 DEAD/DEAH box helicase; Region: DEAD; pfam00270 568703000836 DEAD_2; Region: DEAD_2; pfam06733 568703000837 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 568703000838 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568703000839 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568703000840 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 568703000841 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 568703000842 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703000843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703000844 DNA-binding site [nucleotide binding]; DNA binding site 568703000845 UTRA domain; Region: UTRA; pfam07702 568703000846 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 568703000847 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 568703000848 dimer interface [polypeptide binding]; other site 568703000849 active site 568703000850 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 568703000851 putative active site [active] 568703000852 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 568703000853 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 568703000854 active site 568703000855 dimer interface [polypeptide binding]; other site 568703000856 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 568703000857 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 568703000858 active site 568703000859 phosphorylation site [posttranslational modification] 568703000860 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 568703000861 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 568703000862 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 568703000863 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 568703000864 active pocket/dimerization site; other site 568703000865 active site 568703000866 phosphorylation site [posttranslational modification] 568703000867 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 568703000868 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 568703000869 putative substrate binding site [chemical binding]; other site 568703000870 putative ATP binding site [chemical binding]; other site 568703000871 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 568703000872 classical (c) SDRs; Region: SDR_c; cd05233 568703000873 NAD(P) binding site [chemical binding]; other site 568703000874 active site 568703000875 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 568703000876 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568703000877 Transposase domain (DUF772); Region: DUF772; pfam05598 568703000878 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703000879 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703000880 active site 568703000881 phosphorylation site [posttranslational modification] 568703000882 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 568703000883 active site 568703000884 P-loop; other site 568703000885 phosphorylation site [posttranslational modification] 568703000886 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 568703000887 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 568703000888 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703000889 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 568703000890 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 568703000891 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703000892 Rap/ran-GAP; Region: Rap_GAP; pfam02145 568703000893 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 568703000894 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 568703000895 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703000896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703000897 homodimer interface [polypeptide binding]; other site 568703000898 catalytic residue [active] 568703000899 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 568703000900 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 568703000901 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 568703000902 active site 568703000903 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 568703000904 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 568703000905 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 568703000906 active site 568703000907 P-loop; other site 568703000908 phosphorylation site [posttranslational modification] 568703000909 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 568703000910 active site 568703000911 methionine cluster; other site 568703000912 phosphorylation site [posttranslational modification] 568703000913 metal binding site [ion binding]; metal-binding site 568703000914 exoaminopeptidase; Provisional; Region: PRK09961 568703000915 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 568703000916 oligomer interface [polypeptide binding]; other site 568703000917 active site 568703000918 metal binding site [ion binding]; metal-binding site 568703000919 HTH domain; Region: HTH_11; pfam08279 568703000920 PRD domain; Region: PRD; pfam00874 568703000921 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 568703000922 active site 568703000923 P-loop; other site 568703000924 phosphorylation site [posttranslational modification] 568703000925 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 568703000926 active site 568703000927 phosphorylation site [posttranslational modification] 568703000928 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 568703000929 peptidase T; Region: peptidase-T; TIGR01882 568703000930 metal binding site [ion binding]; metal-binding site 568703000931 dimer interface [polypeptide binding]; other site 568703000932 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568703000933 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568703000934 peptide binding site [polypeptide binding]; other site 568703000935 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 568703000936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703000937 Coenzyme A binding pocket [chemical binding]; other site 568703000938 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703000939 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568703000940 Walker A/P-loop; other site 568703000941 ATP binding site [chemical binding]; other site 568703000942 Q-loop/lid; other site 568703000943 ABC transporter signature motif; other site 568703000944 Walker B; other site 568703000945 D-loop; other site 568703000946 H-loop/switch region; other site 568703000947 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 568703000948 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568703000949 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 568703000950 Walker A/P-loop; other site 568703000951 ATP binding site [chemical binding]; other site 568703000952 Q-loop/lid; other site 568703000953 ABC transporter signature motif; other site 568703000954 Walker B; other site 568703000955 D-loop; other site 568703000956 H-loop/switch region; other site 568703000957 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 568703000958 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 568703000959 Walker A/P-loop; other site 568703000960 ATP binding site [chemical binding]; other site 568703000961 Q-loop/lid; other site 568703000962 ABC transporter signature motif; other site 568703000963 Walker B; other site 568703000964 D-loop; other site 568703000965 H-loop/switch region; other site 568703000966 Putative transcription activator [Transcription]; Region: TenA; COG0819 568703000967 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 568703000968 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 568703000969 substrate binding site [chemical binding]; other site 568703000970 multimerization interface [polypeptide binding]; other site 568703000971 ATP binding site [chemical binding]; other site 568703000972 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 568703000973 thiamine phosphate binding site [chemical binding]; other site 568703000974 active site 568703000975 pyrophosphate binding site [ion binding]; other site 568703000976 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 568703000977 dimer interface [polypeptide binding]; other site 568703000978 substrate binding site [chemical binding]; other site 568703000979 ATP binding site [chemical binding]; other site 568703000980 Amino acid permease; Region: AA_permease_2; pfam13520 568703000981 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568703000982 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568703000983 DNA binding site [nucleotide binding] 568703000984 domain linker motif; other site 568703000985 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 568703000986 ligand binding site [chemical binding]; other site 568703000987 dimerization interface [polypeptide binding]; other site 568703000988 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 568703000989 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568703000990 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 568703000991 substrate binding site [chemical binding]; other site 568703000992 dimer interface [polypeptide binding]; other site 568703000993 ATP binding site [chemical binding]; other site 568703000994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703000995 salt bridge; other site 568703000996 non-specific DNA binding site [nucleotide binding]; other site 568703000997 sequence-specific DNA binding site [nucleotide binding]; other site 568703000998 Transposase domain (DUF772); Region: DUF772; pfam05598 568703000999 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001000 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 568703001001 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 568703001002 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 568703001003 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568703001004 Transposase domain (DUF772); Region: DUF772; pfam05598 568703001005 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001006 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 568703001007 non-specific DNA binding site [nucleotide binding]; other site 568703001008 salt bridge; other site 568703001009 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 568703001010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703001011 putative substrate translocation pore; other site 568703001012 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568703001013 MarR family; Region: MarR_2; cl17246 568703001014 MarR family; Region: MarR_2; cl17246 568703001015 Soybean trypsin inhibitor (Kunitz) family of protease inhibitors. Inhibit proteases by binding with high affinity to their active sites. Trefoil fold, common to interleukins and fibroblast growth factors; Region: STI; cl11466 568703001016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703001017 non-specific DNA binding site [nucleotide binding]; other site 568703001018 salt bridge; other site 568703001019 sequence-specific DNA binding site [nucleotide binding]; other site 568703001020 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 568703001021 HTH domain; Region: HTH_11; pfam08279 568703001022 Mga helix-turn-helix domain; Region: Mga; pfam05043 568703001023 PRD domain; Region: PRD; pfam00874 568703001024 PRD domain; Region: PRD; pfam00874 568703001025 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 568703001026 active site 568703001027 P-loop; other site 568703001028 phosphorylation site [posttranslational modification] 568703001029 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 568703001030 active site 568703001031 phosphorylation site [posttranslational modification] 568703001032 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703001033 active site 568703001034 phosphorylation site [posttranslational modification] 568703001035 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 568703001036 active site 568703001037 P-loop; other site 568703001038 phosphorylation site [posttranslational modification] 568703001039 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 568703001040 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 568703001041 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 568703001042 active site 568703001043 intersubunit interactions; other site 568703001044 catalytic residue [active] 568703001045 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 568703001046 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 568703001047 substrate binding site [chemical binding]; other site 568703001048 hexamer interface [polypeptide binding]; other site 568703001049 metal binding site [ion binding]; metal-binding site 568703001050 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703001051 active site 568703001052 phosphorylation site [posttranslational modification] 568703001053 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 568703001054 active site 568703001055 P-loop; other site 568703001056 phosphorylation site [posttranslational modification] 568703001057 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568703001058 Helix-turn-helix domain; Region: HTH_38; pfam13936 568703001059 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 568703001060 Integrase core domain; Region: rve; pfam00665 568703001061 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 568703001062 transketolase; Reviewed; Region: PRK05899 568703001063 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 568703001064 TPP-binding site [chemical binding]; other site 568703001065 dimer interface [polypeptide binding]; other site 568703001066 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 568703001067 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 568703001068 PYR/PP interface [polypeptide binding]; other site 568703001069 dimer interface [polypeptide binding]; other site 568703001070 TPP binding site [chemical binding]; other site 568703001071 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568703001072 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 568703001073 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568703001074 nucleotide binding site [chemical binding]; other site 568703001075 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 568703001076 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703001077 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 568703001078 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568703001079 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703001080 active site 568703001081 phosphorylation site [posttranslational modification] 568703001082 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 568703001083 active site 568703001084 P-loop; other site 568703001085 phosphorylation site [posttranslational modification] 568703001086 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 568703001087 Helix-turn-helix domain; Region: HTH_38; pfam13936 568703001088 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 568703001089 Integrase core domain; Region: rve; pfam00665 568703001090 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 568703001091 intersubunit interface [polypeptide binding]; other site 568703001092 active site 568703001093 zinc binding site [ion binding]; other site 568703001094 Na+ binding site [ion binding]; other site 568703001095 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 568703001096 intersubunit interface [polypeptide binding]; other site 568703001097 active site 568703001098 zinc binding site [ion binding]; other site 568703001099 Na+ binding site [ion binding]; other site 568703001100 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 568703001101 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 568703001102 active pocket/dimerization site; other site 568703001103 active site 568703001104 phosphorylation site [posttranslational modification] 568703001105 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 568703001106 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 568703001107 putative translaldolase; Provisional; Region: PRK12376 568703001108 catalytic residue [active] 568703001109 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568703001110 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568703001111 DNA binding site [nucleotide binding] 568703001112 domain linker motif; other site 568703001113 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 568703001114 dimerization interface [polypeptide binding]; other site 568703001115 ligand binding site [chemical binding]; other site 568703001116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 568703001117 DNA-binding site [nucleotide binding]; DNA binding site 568703001118 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 568703001119 substrate binding pocket [chemical binding]; other site 568703001120 membrane-bound complex binding site; other site 568703001121 hinge residues; other site 568703001122 PRD domain; Region: PRD; pfam00874 568703001123 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 568703001124 Protein of unknown function; Region: YhfT; pfam10797 568703001125 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 568703001126 active site 568703001127 substrate binding pocket [chemical binding]; other site 568703001128 homodimer interaction site [polypeptide binding]; other site 568703001129 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568703001130 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703001131 catalytic residue [active] 568703001132 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 568703001133 dimer interface [polypeptide binding]; other site 568703001134 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 568703001135 active site 568703001136 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568703001137 substrate binding site [chemical binding]; other site 568703001138 catalytic residue [active] 568703001139 putative mutase; Provisional; Region: PRK12383 568703001140 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 568703001141 Uncharacterized conserved protein [Function unknown]; Region: COG1912 568703001142 hypothetical protein; Provisional; Region: PRK13661 568703001143 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568703001144 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 568703001145 Walker A/P-loop; other site 568703001146 ATP binding site [chemical binding]; other site 568703001147 Q-loop/lid; other site 568703001148 ABC transporter signature motif; other site 568703001149 Walker B; other site 568703001150 D-loop; other site 568703001151 H-loop/switch region; other site 568703001152 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 568703001153 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568703001154 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 568703001155 Walker A/P-loop; other site 568703001156 ATP binding site [chemical binding]; other site 568703001157 Q-loop/lid; other site 568703001158 ABC transporter signature motif; other site 568703001159 Walker B; other site 568703001160 D-loop; other site 568703001161 H-loop/switch region; other site 568703001162 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 568703001163 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 568703001164 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 568703001165 active site 568703001166 octamer interface [polypeptide binding]; other site 568703001167 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 568703001168 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 568703001169 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 568703001170 Helix-turn-helix domain; Region: HTH_38; pfam13936 568703001171 Integrase core domain; Region: rve; pfam00665 568703001172 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 568703001173 multiple promoter invertase; Provisional; Region: mpi; PRK13413 568703001174 catalytic residues [active] 568703001175 catalytic nucleophile [active] 568703001176 Presynaptic Site I dimer interface [polypeptide binding]; other site 568703001177 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 568703001178 Synaptic Flat tetramer interface [polypeptide binding]; other site 568703001179 Synaptic Site I dimer interface [polypeptide binding]; other site 568703001180 DNA binding site [nucleotide binding] 568703001181 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 568703001182 Dimer interface [polypeptide binding]; other site 568703001183 AP2 domain; Region: AP2; pfam00847 568703001184 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 568703001185 active site 568703001186 catalytic site [active] 568703001187 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 568703001188 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 568703001189 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 568703001190 metal ion-dependent adhesion site (MIDAS); other site 568703001191 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 568703001192 domain interaction interfaces [polypeptide binding]; other site 568703001193 Cna protein B-type domain; Region: Cna_B; pfam05738 568703001194 Cna protein B-type domain; Region: Cna_B; pfam05738 568703001195 Helix-turn-helix domain; Region: HTH_38; pfam13936 568703001196 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 568703001197 Integrase core domain; Region: rve; pfam00665 568703001198 Uncharacterized conserved protein [Function unknown]; Region: COG3410 568703001199 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 568703001200 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 568703001201 Part of AAA domain; Region: AAA_19; pfam13245 568703001202 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 568703001203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703001204 Walker A/P-loop; other site 568703001205 ATP binding site [chemical binding]; other site 568703001206 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 568703001207 putative active site [active] 568703001208 putative metal-binding site [ion binding]; other site 568703001209 Transposase domain (DUF772); Region: DUF772; pfam05598 568703001210 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001211 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568703001212 Transposase; Region: HTH_Tnp_1; pfam01527 568703001213 putative transposase OrfB; Reviewed; Region: PHA02517 568703001214 HTH-like domain; Region: HTH_21; pfam13276 568703001215 Integrase core domain; Region: rve; pfam00665 568703001216 Integrase core domain; Region: rve_3; pfam13683 568703001217 putative transposase OrfB; Reviewed; Region: PHA02517 568703001218 HTH-like domain; Region: HTH_21; pfam13276 568703001219 Integrase core domain; Region: rve; pfam00665 568703001220 Integrase core domain; Region: rve_2; pfam13333 568703001221 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 568703001222 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 568703001223 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703001224 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 568703001225 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703001226 active site 568703001227 motif I; other site 568703001228 motif II; other site 568703001229 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568703001230 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568703001231 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703001232 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001233 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 568703001234 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 568703001235 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703001236 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001237 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568703001238 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 568703001239 Integrase core domain; Region: rve; pfam00665 568703001240 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 568703001241 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 568703001242 Cl- selectivity filter; other site 568703001243 Cl- binding residues [ion binding]; other site 568703001244 pore gating glutamate residue; other site 568703001245 dimer interface [polypeptide binding]; other site 568703001246 H+/Cl- coupling transport residue; other site 568703001247 TrkA-C domain; Region: TrkA_C; pfam02080 568703001248 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 568703001249 Helix-turn-helix domain; Region: HTH_38; pfam13936 568703001250 Integrase core domain; Region: rve; pfam00665 568703001251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703001252 D-galactonate transporter; Region: 2A0114; TIGR00893 568703001253 putative substrate translocation pore; other site 568703001254 Transposase domain (DUF772); Region: DUF772; pfam05598 568703001255 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001256 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 568703001257 hypothetical protein; Provisional; Region: PRK06446 568703001258 metal binding site [ion binding]; metal-binding site 568703001259 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703001260 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703001261 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703001262 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703001263 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 568703001264 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 568703001265 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 568703001266 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 568703001267 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 568703001268 inner membrane transporter YjeM; Provisional; Region: PRK15238 568703001269 lysine transporter; Provisional; Region: PRK10836 568703001270 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 568703001271 Transcriptional regulator; Region: Rrf2; cl17282 568703001272 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568703001273 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568703001274 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 568703001275 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568703001276 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 568703001277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703001278 D-galactonate transporter; Region: 2A0114; TIGR00893 568703001279 putative substrate translocation pore; other site 568703001280 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 568703001281 amidohydrolase; Region: amidohydrolases; TIGR01891 568703001282 putative metal binding site [ion binding]; other site 568703001283 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 568703001284 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 568703001285 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568703001286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703001287 Walker A/P-loop; other site 568703001288 ATP binding site [chemical binding]; other site 568703001289 Q-loop/lid; other site 568703001290 ABC transporter signature motif; other site 568703001291 Walker B; other site 568703001292 D-loop; other site 568703001293 H-loop/switch region; other site 568703001294 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703001295 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703001296 substrate binding pocket [chemical binding]; other site 568703001297 membrane-bound complex binding site; other site 568703001298 hinge residues; other site 568703001299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703001300 dimer interface [polypeptide binding]; other site 568703001301 conserved gate region; other site 568703001302 putative PBP binding loops; other site 568703001303 ABC-ATPase subunit interface; other site 568703001304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703001305 dimer interface [polypeptide binding]; other site 568703001306 conserved gate region; other site 568703001307 putative PBP binding loops; other site 568703001308 ABC-ATPase subunit interface; other site 568703001309 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 568703001310 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 568703001311 DNA binding residues [nucleotide binding] 568703001312 dimerization interface [polypeptide binding]; other site 568703001313 YvrJ protein family; Region: YvrJ; pfam12841 568703001314 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 568703001315 active site 568703001316 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 568703001317 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568703001318 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703001319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703001320 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568703001321 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 568703001322 FtsX-like permease family; Region: FtsX; pfam02687 568703001323 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703001324 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568703001325 Walker A/P-loop; other site 568703001326 ATP binding site [chemical binding]; other site 568703001327 Q-loop/lid; other site 568703001328 ABC transporter signature motif; other site 568703001329 Walker B; other site 568703001330 D-loop; other site 568703001331 H-loop/switch region; other site 568703001332 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 568703001333 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703001334 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568703001335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703001336 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703001337 active site 568703001338 motif I; other site 568703001339 motif II; other site 568703001340 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 568703001341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 568703001342 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 568703001343 active site 568703001344 NTP binding site [chemical binding]; other site 568703001345 metal binding triad [ion binding]; metal-binding site 568703001346 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 568703001347 Transposase domain (DUF772); Region: DUF772; pfam05598 568703001348 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001349 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 568703001350 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 568703001351 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 568703001352 active site 568703001353 myosin-cross-reactive antigen; Provisional; Region: PRK13977 568703001354 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 568703001355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703001356 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 568703001357 DAK2 domain; Region: Dak2; cl03685 568703001358 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 568703001359 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 568703001360 OsmC-like protein; Region: OsmC; cl00767 568703001361 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568703001362 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703001363 Walker A/P-loop; other site 568703001364 ATP binding site [chemical binding]; other site 568703001365 Q-loop/lid; other site 568703001366 ABC transporter signature motif; other site 568703001367 Walker B; other site 568703001368 D-loop; other site 568703001369 H-loop/switch region; other site 568703001370 Transposase domain (DUF772); Region: DUF772; pfam05598 568703001371 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001372 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703001373 non-specific DNA binding site [nucleotide binding]; other site 568703001374 salt bridge; other site 568703001375 sequence-specific DNA binding site [nucleotide binding]; other site 568703001376 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 568703001377 Transposase domain (DUF772); Region: DUF772; pfam05598 568703001378 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001379 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 568703001380 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 568703001381 active site 568703001382 catalytic site [active] 568703001383 substrate binding site [chemical binding]; other site 568703001384 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568703001385 dimerization interface [polypeptide binding]; other site 568703001386 putative DNA binding site [nucleotide binding]; other site 568703001387 putative Zn2+ binding site [ion binding]; other site 568703001388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703001389 benzoate transport; Region: 2A0115; TIGR00895 568703001390 putative substrate translocation pore; other site 568703001391 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 568703001392 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 568703001393 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 568703001394 intersubunit interface [polypeptide binding]; other site 568703001395 active site 568703001396 zinc binding site [ion binding]; other site 568703001397 Na+ binding site [ion binding]; other site 568703001398 pyruvate oxidase; Provisional; Region: PRK08611 568703001399 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 568703001400 PYR/PP interface [polypeptide binding]; other site 568703001401 dimer interface [polypeptide binding]; other site 568703001402 tetramer interface [polypeptide binding]; other site 568703001403 TPP binding site [chemical binding]; other site 568703001404 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568703001405 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 568703001406 TPP-binding site [chemical binding]; other site 568703001407 Beta-lactamase; Region: Beta-lactamase; cl17358 568703001408 Beta-lactamase; Region: Beta-lactamase; pfam00144 568703001409 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568703001410 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 568703001411 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 568703001412 active site 568703001413 Methyltransferase domain; Region: Methyltransf_31; pfam13847 568703001414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703001415 S-adenosylmethionine binding site [chemical binding]; other site 568703001416 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 568703001417 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 568703001418 catalytic triad [active] 568703001419 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 568703001420 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 568703001421 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568703001422 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 568703001423 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 568703001424 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 568703001425 DNA binding residues [nucleotide binding] 568703001426 putative dimer interface [polypeptide binding]; other site 568703001427 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703001428 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703001429 active site 568703001430 catalytic tetrad [active] 568703001431 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 568703001432 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 568703001433 putative NAD(P) binding site [chemical binding]; other site 568703001434 dimer interface [polypeptide binding]; other site 568703001435 Predicted transcriptional regulators [Transcription]; Region: COG1733 568703001436 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 568703001437 hypothetical protein; Provisional; Region: PRK10621 568703001438 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568703001439 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703001440 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 568703001441 Walker A/P-loop; other site 568703001442 ATP binding site [chemical binding]; other site 568703001443 Q-loop/lid; other site 568703001444 ABC transporter signature motif; other site 568703001445 Walker B; other site 568703001446 D-loop; other site 568703001447 H-loop/switch region; other site 568703001448 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703001449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703001450 active site 568703001451 phosphorylation site [posttranslational modification] 568703001452 intermolecular recognition site; other site 568703001453 dimerization interface [polypeptide binding]; other site 568703001454 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703001455 DNA binding site [nucleotide binding] 568703001456 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 568703001457 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703001458 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568703001459 dimerization interface [polypeptide binding]; other site 568703001460 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703001461 dimer interface [polypeptide binding]; other site 568703001462 phosphorylation site [posttranslational modification] 568703001463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703001464 ATP binding site [chemical binding]; other site 568703001465 Mg2+ binding site [ion binding]; other site 568703001466 G-X-G motif; other site 568703001467 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703001468 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 568703001469 Walker A/P-loop; other site 568703001470 ATP binding site [chemical binding]; other site 568703001471 Q-loop/lid; other site 568703001472 ABC transporter signature motif; other site 568703001473 Walker B; other site 568703001474 D-loop; other site 568703001475 H-loop/switch region; other site 568703001476 Peptidase family M1; Region: Peptidase_M1; pfam01433 568703001477 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 568703001478 Zn binding site [ion binding]; other site 568703001479 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 568703001480 inner membrane transporter YjeM; Provisional; Region: PRK15238 568703001481 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 568703001482 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 568703001483 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 568703001484 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703001485 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703001486 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 568703001487 putative dimerization interface [polypeptide binding]; other site 568703001488 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 568703001489 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 568703001490 classical (c) SDRs; Region: SDR_c; cd05233 568703001491 NAD(P) binding site [chemical binding]; other site 568703001492 active site 568703001493 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 568703001494 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 568703001495 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 568703001496 shikimate binding site; other site 568703001497 NAD(P) binding site [chemical binding]; other site 568703001498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703001499 putative substrate translocation pore; other site 568703001500 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703001501 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 568703001502 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 568703001503 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 568703001504 shikimate binding site; other site 568703001505 NAD(P) binding site [chemical binding]; other site 568703001506 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 568703001507 proposed active site lysine [active] 568703001508 conserved cys residue [active] 568703001509 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 568703001510 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 568703001511 dimer interface [polypeptide binding]; other site 568703001512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703001513 catalytic residue [active] 568703001514 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 568703001515 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 568703001516 homodimer interface [polypeptide binding]; other site 568703001517 substrate-cofactor binding pocket; other site 568703001518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703001519 catalytic residue [active] 568703001520 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703001521 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703001522 substrate binding pocket [chemical binding]; other site 568703001523 membrane-bound complex binding site; other site 568703001524 hinge residues; other site 568703001525 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703001526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703001527 dimer interface [polypeptide binding]; other site 568703001528 conserved gate region; other site 568703001529 putative PBP binding loops; other site 568703001530 ABC-ATPase subunit interface; other site 568703001531 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 568703001532 WxL domain surface cell wall-binding; Region: WxL; pfam13731 568703001533 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 568703001534 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 568703001535 legume lectins; Region: lectin_L-type; cd01951 568703001536 homotetramer interaction site [polypeptide binding]; other site 568703001537 homodimer interaction site [polypeptide binding]; other site 568703001538 carbohydrate binding site [chemical binding]; other site 568703001539 metal binding site [ion binding]; metal-binding site 568703001540 WxL domain surface cell wall-binding; Region: WxL; pfam13731 568703001541 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568703001542 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703001543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703001544 WxL domain surface cell wall-binding; Region: WxL; pfam13731 568703001545 WxL domain surface cell wall-binding; Region: WxL; pfam13731 568703001546 legume lectins; Region: lectin_L-type; cd01951 568703001547 homotetramer interaction site [polypeptide binding]; other site 568703001548 carbohydrate binding site [chemical binding]; other site 568703001549 metal binding site [ion binding]; metal-binding site 568703001550 WxL domain surface cell wall-binding; Region: WxL; pfam13731 568703001551 EamA-like transporter family; Region: EamA; pfam00892 568703001552 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 568703001553 EamA-like transporter family; Region: EamA; pfam00892 568703001554 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 568703001555 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703001556 Walker A/P-loop; other site 568703001557 ATP binding site [chemical binding]; other site 568703001558 Q-loop/lid; other site 568703001559 ABC transporter signature motif; other site 568703001560 Walker B; other site 568703001561 D-loop; other site 568703001562 H-loop/switch region; other site 568703001563 Transposase domain (DUF772); Region: DUF772; pfam05598 568703001564 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703001565 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 568703001566 substrate binding site [chemical binding]; other site 568703001567 ATP binding site [chemical binding]; other site 568703001568 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 568703001569 FAD binding site [chemical binding]; other site 568703001570 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 568703001571 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 568703001572 THF binding site; other site 568703001573 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 568703001574 substrate binding site [chemical binding]; other site 568703001575 THF binding site; other site 568703001576 zinc-binding site [ion binding]; other site 568703001577 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703001578 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703001579 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703001580 Walker A/P-loop; other site 568703001581 ATP binding site [chemical binding]; other site 568703001582 Q-loop/lid; other site 568703001583 ABC transporter signature motif; other site 568703001584 Walker B; other site 568703001585 D-loop; other site 568703001586 H-loop/switch region; other site 568703001587 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703001588 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703001589 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 568703001590 Walker A/P-loop; other site 568703001591 ATP binding site [chemical binding]; other site 568703001592 Q-loop/lid; other site 568703001593 ABC transporter signature motif; other site 568703001594 Walker B; other site 568703001595 D-loop; other site 568703001596 H-loop/switch region; other site 568703001597 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 568703001598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703001599 putative substrate translocation pore; other site 568703001600 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 568703001601 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703001602 DNA-binding site [nucleotide binding]; DNA binding site 568703001603 UTRA domain; Region: UTRA; pfam07702 568703001604 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 568703001605 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 568703001606 Ca binding site [ion binding]; other site 568703001607 active site 568703001608 catalytic site [active] 568703001609 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 568703001610 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 568703001611 HPr interaction site; other site 568703001612 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568703001613 active site 568703001614 phosphorylation site [posttranslational modification] 568703001615 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 568703001616 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 568703001617 active site turn [active] 568703001618 phosphorylation site [posttranslational modification] 568703001619 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568703001620 serine/threonine transporter SstT; Provisional; Region: PRK13628 568703001621 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 568703001622 amino acid transporter; Region: 2A0306; TIGR00909 568703001623 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 568703001624 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 568703001625 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 568703001626 NAD binding site [chemical binding]; other site 568703001627 dimer interface [polypeptide binding]; other site 568703001628 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703001629 substrate binding site [chemical binding]; other site 568703001630 putative transport protein YifK; Provisional; Region: PRK10746 568703001631 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703001632 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703001633 active site 568703001634 catalytic tetrad [active] 568703001635 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 568703001636 NADH(P)-binding; Region: NAD_binding_10; pfam13460 568703001637 NAD(P) binding site [chemical binding]; other site 568703001638 putative active site [active] 568703001639 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 568703001640 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703001641 ABC transporter; Region: ABC_tran_2; pfam12848 568703001642 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703001643 OsmC-like protein; Region: OsmC; pfam02566 568703001644 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 568703001645 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568703001646 DNA-binding site [nucleotide binding]; DNA binding site 568703001647 RNA-binding motif; other site 568703001648 glutamate dehydrogenase; Provisional; Region: PRK09414 568703001649 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 568703001650 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 568703001651 NAD(P) binding site [chemical binding]; other site 568703001652 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 568703001653 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 568703001654 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 568703001655 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 568703001656 LytTr DNA-binding domain; Region: LytTR; smart00850 568703001657 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703001658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703001659 Walker A/P-loop; other site 568703001660 ATP binding site [chemical binding]; other site 568703001661 Q-loop/lid; other site 568703001662 ABC transporter signature motif; other site 568703001663 Walker B; other site 568703001664 D-loop; other site 568703001665 H-loop/switch region; other site 568703001666 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 568703001667 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 568703001668 active site 568703001669 zinc binding site [ion binding]; other site 568703001670 hypothetical protein; Provisional; Region: PRK00967 568703001671 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 568703001672 nudix motif; other site 568703001673 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703001674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703001675 active site 568703001676 phosphorylation site [posttranslational modification] 568703001677 intermolecular recognition site; other site 568703001678 dimerization interface [polypeptide binding]; other site 568703001679 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703001680 DNA binding site [nucleotide binding] 568703001681 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703001682 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703001683 dimer interface [polypeptide binding]; other site 568703001684 phosphorylation site [posttranslational modification] 568703001685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703001686 ATP binding site [chemical binding]; other site 568703001687 Mg2+ binding site [ion binding]; other site 568703001688 G-X-G motif; other site 568703001689 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703001690 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703001691 Walker A/P-loop; other site 568703001692 ATP binding site [chemical binding]; other site 568703001693 Q-loop/lid; other site 568703001694 ABC transporter signature motif; other site 568703001695 Walker B; other site 568703001696 D-loop; other site 568703001697 H-loop/switch region; other site 568703001698 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 568703001699 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 568703001700 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 568703001701 putative NAD(P) binding site [chemical binding]; other site 568703001702 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 568703001703 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 568703001704 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 568703001705 MgtC family; Region: MgtC; pfam02308 568703001706 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 568703001707 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 568703001708 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703001709 Walker A/P-loop; other site 568703001710 ATP binding site [chemical binding]; other site 568703001711 ABC transporter signature motif; other site 568703001712 Walker B; other site 568703001713 D-loop; other site 568703001714 H-loop/switch region; other site 568703001715 ABC transporter; Region: ABC_tran_2; pfam12848 568703001716 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703001717 potential frameshift: common BLAST hit: gi|301065706|ref|YP_003787729.1| mismatch repair ATPase (mutS family) 568703001718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703001719 Walker A/P-loop; other site 568703001720 ATP binding site [chemical binding]; other site 568703001721 Q-loop/lid; other site 568703001722 ABC transporter signature motif; other site 568703001723 Walker B; other site 568703001724 D-loop; other site 568703001725 H-loop/switch region; other site 568703001726 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 568703001727 putative uracil binding site [chemical binding]; other site 568703001728 putative active site [active] 568703001729 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 568703001730 amphipathic channel; other site 568703001731 Asn-Pro-Ala signature motifs; other site 568703001732 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 568703001733 glycerol kinase; Provisional; Region: glpK; PRK00047 568703001734 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 568703001735 N- and C-terminal domain interface [polypeptide binding]; other site 568703001736 active site 568703001737 MgATP binding site [chemical binding]; other site 568703001738 catalytic site [active] 568703001739 metal binding site [ion binding]; metal-binding site 568703001740 glycerol binding site [chemical binding]; other site 568703001741 homotetramer interface [polypeptide binding]; other site 568703001742 homodimer interface [polypeptide binding]; other site 568703001743 FBP binding site [chemical binding]; other site 568703001744 protein IIAGlc interface [polypeptide binding]; other site 568703001745 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 568703001746 active site 568703001747 PRD domain; Region: PRD; pfam00874 568703001748 PRD domain; Region: PRD; pfam00874 568703001749 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 568703001750 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 568703001751 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 568703001752 active site 568703001753 P-loop; other site 568703001754 phosphorylation site [posttranslational modification] 568703001755 potential frameshift: common BLAST hit: gi|258538814|ref|YP_003173313.1| 6-phospho-beta-galactosidase 568703001756 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 568703001757 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 568703001758 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 568703001759 methionine cluster; other site 568703001760 active site 568703001761 phosphorylation site [posttranslational modification] 568703001762 metal binding site [ion binding]; metal-binding site 568703001763 galactokinase; Provisional; Region: PRK05322 568703001764 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 568703001765 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 568703001766 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 568703001767 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 568703001768 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 568703001769 NAD binding site [chemical binding]; other site 568703001770 homodimer interface [polypeptide binding]; other site 568703001771 active site 568703001772 substrate binding site [chemical binding]; other site 568703001773 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 568703001774 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 568703001775 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 568703001776 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568703001777 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568703001778 DNA binding site [nucleotide binding] 568703001779 domain linker motif; other site 568703001780 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 568703001781 putative dimerization interface [polypeptide binding]; other site 568703001782 putative ligand binding site [chemical binding]; other site 568703001783 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 568703001784 active site 568703001785 catalytic residues [active] 568703001786 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568703001787 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568703001788 Beta-lactamase; Region: Beta-lactamase; pfam00144 568703001789 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 568703001790 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 568703001791 putative substrate binding site [chemical binding]; other site 568703001792 putative ATP binding site [chemical binding]; other site 568703001793 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 568703001794 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 568703001795 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 568703001796 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703001797 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 568703001798 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568703001799 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 568703001800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703001801 active site 568703001802 motif I; other site 568703001803 motif II; other site 568703001804 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 568703001805 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 568703001806 active site 568703001807 metal binding site [ion binding]; metal-binding site 568703001808 DNA binding site [nucleotide binding] 568703001809 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 568703001810 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 568703001811 AAA domain; Region: AAA_23; pfam13476 568703001812 Walker A/P-loop; other site 568703001813 ATP binding site [chemical binding]; other site 568703001814 Q-loop/lid; other site 568703001815 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 568703001816 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703001817 ABC transporter signature motif; other site 568703001818 Walker B; other site 568703001819 D-loop; other site 568703001820 H-loop/switch region; other site 568703001821 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 568703001822 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 568703001823 putative dimer interface [polypeptide binding]; other site 568703001824 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 568703001825 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568703001826 minor groove reading motif; other site 568703001827 helix-hairpin-helix signature motif; other site 568703001828 substrate binding pocket [chemical binding]; other site 568703001829 active site 568703001830 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 568703001831 DNA binding and oxoG recognition site [nucleotide binding] 568703001832 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 568703001833 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 568703001834 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 568703001835 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 568703001836 dimer interface [polypeptide binding]; other site 568703001837 substrate binding site [chemical binding]; other site 568703001838 ATP binding site [chemical binding]; other site 568703001839 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 568703001840 NADH(P)-binding; Region: NAD_binding_10; pfam13460 568703001841 NAD binding site [chemical binding]; other site 568703001842 substrate binding site [chemical binding]; other site 568703001843 putative active site [active] 568703001844 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 568703001845 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 568703001846 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 568703001847 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 568703001848 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 568703001849 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 568703001850 zinc binding site [ion binding]; other site 568703001851 putative ligand binding site [chemical binding]; other site 568703001852 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 568703001853 zinc binding site [ion binding]; other site 568703001854 putative ligand binding site [chemical binding]; other site 568703001855 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568703001856 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 568703001857 TM-ABC transporter signature motif; other site 568703001858 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 568703001859 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703001860 Walker A/P-loop; other site 568703001861 ATP binding site [chemical binding]; other site 568703001862 Q-loop/lid; other site 568703001863 ABC transporter signature motif; other site 568703001864 Walker B; other site 568703001865 D-loop; other site 568703001866 H-loop/switch region; other site 568703001867 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 568703001868 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 568703001869 NADP binding site [chemical binding]; other site 568703001870 dimer interface [polypeptide binding]; other site 568703001871 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 568703001872 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 568703001873 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703001874 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 568703001875 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703001876 motif II; other site 568703001877 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568703001878 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 568703001879 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 568703001880 Ligand binding site; other site 568703001881 Putative Catalytic site; other site 568703001882 DXD motif; other site 568703001883 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 568703001884 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 568703001885 Predicted membrane protein [Function unknown]; Region: COG2246 568703001886 GtrA-like protein; Region: GtrA; pfam04138 568703001887 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703001888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703001889 active site 568703001890 phosphorylation site [posttranslational modification] 568703001891 intermolecular recognition site; other site 568703001892 dimerization interface [polypeptide binding]; other site 568703001893 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703001894 DNA binding site [nucleotide binding] 568703001895 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703001896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703001897 dimer interface [polypeptide binding]; other site 568703001898 phosphorylation site [posttranslational modification] 568703001899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703001900 ATP binding site [chemical binding]; other site 568703001901 Mg2+ binding site [ion binding]; other site 568703001902 G-X-G motif; other site 568703001903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 568703001904 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 568703001905 hypothetical protein; Provisional; Region: PRK06194 568703001906 classical (c) SDRs; Region: SDR_c; cd05233 568703001907 NAD(P) binding site [chemical binding]; other site 568703001908 active site 568703001909 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 568703001910 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 568703001911 dimer interface [polypeptide binding]; other site 568703001912 FMN binding site [chemical binding]; other site 568703001913 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 568703001914 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 568703001915 phosphate binding site [ion binding]; other site 568703001916 Predicted transcriptional regulators [Transcription]; Region: COG1695 568703001917 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 568703001918 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 568703001919 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 568703001920 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 568703001921 putative NAD(P) binding site [chemical binding]; other site 568703001922 dimer interface [polypeptide binding]; other site 568703001923 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 568703001924 Domain of unknown function DUF20; Region: UPF0118; pfam01594 568703001925 LexA repressor; Validated; Region: PRK00215 568703001926 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 568703001927 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 568703001928 Catalytic site [active] 568703001929 Membrane transport protein; Region: Mem_trans; pfam03547 568703001930 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 568703001931 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 568703001932 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 568703001933 Uncharacterized conserved protein [Function unknown]; Region: COG3189 568703001934 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 568703001935 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 568703001936 Cl binding site [ion binding]; other site 568703001937 oligomer interface [polypeptide binding]; other site 568703001938 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703001939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703001940 The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437 568703001941 putative dimerization interface [polypeptide binding]; other site 568703001942 malate dehydrogenase; Provisional; Region: PRK13529 568703001943 Malic enzyme, N-terminal domain; Region: malic; pfam00390 568703001944 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 568703001945 NAD(P) binding site [chemical binding]; other site 568703001946 Membrane transport protein; Region: Mem_trans; cl09117 568703001947 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 568703001948 dimer interface [polypeptide binding]; other site 568703001949 catalytic triad [active] 568703001950 peroxidatic and resolving cysteines [active] 568703001951 Flavodoxin domain; Region: Flavodoxin_5; cl17428 568703001952 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703001953 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703001954 non-specific DNA binding site [nucleotide binding]; other site 568703001955 salt bridge; other site 568703001956 sequence-specific DNA binding site [nucleotide binding]; other site 568703001957 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 568703001958 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703001959 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703001960 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568703001961 Walker A/P-loop; other site 568703001962 ATP binding site [chemical binding]; other site 568703001963 Q-loop/lid; other site 568703001964 ABC transporter signature motif; other site 568703001965 Walker B; other site 568703001966 D-loop; other site 568703001967 H-loop/switch region; other site 568703001968 oligoendopeptidase F; Region: pepF; TIGR00181 568703001969 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 568703001970 active site 568703001971 Zn binding site [ion binding]; other site 568703001972 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 568703001973 active site 568703001974 multimer interface [polypeptide binding]; other site 568703001975 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703001976 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 568703001977 Soluble P-type ATPase [General function prediction only]; Region: COG4087 568703001978 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 568703001979 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 568703001980 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 568703001981 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 568703001982 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703001983 motif II; other site 568703001984 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 568703001985 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568703001986 MarR family; Region: MarR_2; pfam12802 568703001987 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568703001988 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 568703001989 flavoprotein NrdI; Provisional; Region: PRK02551 568703001990 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703001991 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703001992 active site 568703001993 catalytic tetrad [active] 568703001994 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 568703001995 Predicted membrane protein [Function unknown]; Region: COG2323 568703001996 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 568703001997 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 568703001998 substrate binding site [chemical binding]; other site 568703001999 zinc-binding site [ion binding]; other site 568703002000 S-ribosylhomocysteinase; Provisional; Region: PRK02260 568703002001 Uncharacterized conserved protein [Function unknown]; Region: COG0398 568703002002 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 568703002003 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 568703002004 RuvA N terminal domain; Region: RuvA_N; pfam01330 568703002005 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 568703002006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703002007 Walker A motif; other site 568703002008 ATP binding site [chemical binding]; other site 568703002009 Walker B motif; other site 568703002010 arginine finger; other site 568703002011 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 568703002012 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 568703002013 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 568703002014 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 568703002015 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 568703002016 Preprotein translocase subunit; Region: YajC; pfam02699 568703002017 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 568703002018 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 568703002019 putative catalytic cysteine [active] 568703002020 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 568703002021 putative active site [active] 568703002022 metal binding site [ion binding]; metal-binding site 568703002023 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 568703002024 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 568703002025 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 568703002026 FeoA domain; Region: FeoA; pfam04023 568703002027 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 568703002028 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 568703002029 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 568703002030 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 568703002031 active site 568703002032 DNA polymerase IV; Validated; Region: PRK02406 568703002033 DNA binding site [nucleotide binding] 568703002034 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 568703002035 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703002036 DNA-binding site [nucleotide binding]; DNA binding site 568703002037 DRTGG domain; Region: DRTGG; pfam07085 568703002038 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 568703002039 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 568703002040 DHH family; Region: DHH; pfam01368 568703002041 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 568703002042 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 568703002043 ATP binding site [chemical binding]; other site 568703002044 Mg++ binding site [ion binding]; other site 568703002045 motif III; other site 568703002046 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703002047 nucleotide binding region [chemical binding]; other site 568703002048 ATP-binding site [chemical binding]; other site 568703002049 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 568703002050 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 568703002051 motif 1; other site 568703002052 active site 568703002053 motif 2; other site 568703002054 motif 3; other site 568703002055 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 568703002056 DHHA1 domain; Region: DHHA1; pfam02272 568703002057 hypothetical protein; Provisional; Region: PRK05473 568703002058 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 568703002059 hypothetical protein; Provisional; Region: PRK13678 568703002060 Cell division protein ZapA; Region: ZapA; pfam05164 568703002061 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 568703002062 Colicin V production protein; Region: Colicin_V; pfam02674 568703002063 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 568703002064 MutS domain III; Region: MutS_III; pfam05192 568703002065 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703002066 Walker A/P-loop; other site 568703002067 ATP binding site [chemical binding]; other site 568703002068 Q-loop/lid; other site 568703002069 ABC transporter signature motif; other site 568703002070 Walker B; other site 568703002071 D-loop; other site 568703002072 H-loop/switch region; other site 568703002073 Smr domain; Region: Smr; pfam01713 568703002074 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568703002075 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 568703002076 catalytic residues [active] 568703002077 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 568703002078 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 568703002079 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 568703002080 acyl-activating enzyme (AAE) consensus motif; other site 568703002081 AMP binding site [chemical binding]; other site 568703002082 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 568703002083 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 568703002084 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 568703002085 DltD N-terminal region; Region: DltD_N; pfam04915 568703002086 DltD central region; Region: DltD_M; pfam04918 568703002087 DltD C-terminal region; Region: DltD_C; pfam04914 568703002088 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 568703002089 glutamate racemase; Provisional; Region: PRK00865 568703002090 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 568703002091 active site 568703002092 dimerization interface [polypeptide binding]; other site 568703002093 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 568703002094 active site 568703002095 metal binding site [ion binding]; metal-binding site 568703002096 homotetramer interface [polypeptide binding]; other site 568703002097 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 568703002098 amphipathic channel; other site 568703002099 Asn-Pro-Ala signature motifs; other site 568703002100 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 568703002101 FOG: CBS domain [General function prediction only]; Region: COG0517 568703002102 Domain of unknown function (DUF368); Region: DUF368; pfam04018 568703002103 Mechanosensitive ion channel; Region: MS_channel; pfam00924 568703002104 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 568703002105 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 568703002106 YtxH-like protein; Region: YtxH; pfam12732 568703002107 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 568703002108 HTH domain; Region: HTH_11; pfam08279 568703002109 3H domain; Region: 3H; pfam02829 568703002110 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 568703002111 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 568703002112 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 568703002113 active site 568703002114 catabolite control protein A; Region: ccpA; TIGR01481 568703002115 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568703002116 DNA binding site [nucleotide binding] 568703002117 domain linker motif; other site 568703002118 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 568703002119 dimerization interface [polypeptide binding]; other site 568703002120 effector binding site; other site 568703002121 Transglycosylase; Region: Transgly; pfam00912 568703002122 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 568703002123 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 568703002124 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 568703002125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703002126 motif II; other site 568703002127 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 568703002128 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 568703002129 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 568703002130 dipeptidase PepV; Reviewed; Region: PRK07318 568703002131 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 568703002132 active site 568703002133 metal binding site [ion binding]; metal-binding site 568703002134 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 568703002135 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 568703002136 active site 568703002137 catalytic site [active] 568703002138 metal binding site [ion binding]; metal-binding site 568703002139 YibE/F-like protein; Region: YibE_F; pfam07907 568703002140 YibE/F-like protein; Region: YibE_F; cl02259 568703002141 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 568703002142 putative active site [active] 568703002143 putative metal binding site [ion binding]; other site 568703002144 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 568703002145 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568703002146 active site 568703002147 metal binding site [ion binding]; metal-binding site 568703002148 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 568703002149 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 568703002150 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 568703002151 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703002152 active site 568703002153 motif I; other site 568703002154 motif II; other site 568703002155 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703002156 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 568703002157 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 568703002158 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 568703002159 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 568703002160 tetramer interfaces [polypeptide binding]; other site 568703002161 binuclear metal-binding site [ion binding]; other site 568703002162 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 568703002163 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568703002164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703002165 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 568703002166 active site 568703002167 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 568703002168 RNA binding site [nucleotide binding]; other site 568703002169 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 568703002170 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568703002171 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 568703002172 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703002173 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 568703002174 putative ADP-binding pocket [chemical binding]; other site 568703002175 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703002176 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 568703002177 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 568703002178 aromatic amino acid aminotransferase; Validated; Region: PRK07309 568703002179 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703002180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703002181 homodimer interface [polypeptide binding]; other site 568703002182 catalytic residue [active] 568703002183 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 568703002184 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 568703002185 Sulfatase; Region: Sulfatase; pfam00884 568703002186 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 568703002187 metal binding site 2 [ion binding]; metal-binding site 568703002188 putative DNA binding helix; other site 568703002189 metal binding site 1 [ion binding]; metal-binding site 568703002190 dimer interface [polypeptide binding]; other site 568703002191 structural Zn2+ binding site [ion binding]; other site 568703002192 S-adenosylmethionine synthetase; Validated; Region: PRK05250 568703002193 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 568703002194 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 568703002195 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 568703002196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002197 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703002198 putative substrate translocation pore; other site 568703002199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002200 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 568703002201 DNA binding residues [nucleotide binding] 568703002202 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 568703002203 putative dimer interface [polypeptide binding]; other site 568703002204 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568703002205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002206 putative substrate translocation pore; other site 568703002207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002208 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 568703002209 active site 568703002210 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 568703002211 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 568703002212 HIGH motif; other site 568703002213 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 568703002214 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 568703002215 active site 568703002216 KMSKS motif; other site 568703002217 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 568703002218 tRNA binding surface [nucleotide binding]; other site 568703002219 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 568703002220 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 568703002221 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 568703002222 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703002223 RNA binding surface [nucleotide binding]; other site 568703002224 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 568703002225 active site 568703002226 uracil binding [chemical binding]; other site 568703002227 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 568703002228 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 568703002229 putative substrate binding site [chemical binding]; other site 568703002230 putative ATP binding site [chemical binding]; other site 568703002231 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 568703002232 nudix motif; other site 568703002233 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 568703002234 catalytic residues [active] 568703002235 dimer interface [polypeptide binding]; other site 568703002236 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 568703002237 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703002238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703002239 homodimer interface [polypeptide binding]; other site 568703002240 catalytic residue [active] 568703002241 potential frameshift: common BLAST hit: gi|191637787|ref|YP_001986953.1| 3 ,5-cyclic-nucleotide phosphodiesterase 568703002242 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 568703002243 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 568703002244 active site 568703002245 metal binding site [ion binding]; metal-binding site 568703002246 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 568703002247 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 568703002248 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 568703002249 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 568703002250 Competence protein CoiA-like family; Region: CoiA; cl11541 568703002251 Thioredoxin; Region: Thioredoxin_5; pfam13743 568703002252 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 568703002253 putative active site [active] 568703002254 putative metal binding residues [ion binding]; other site 568703002255 signature motif; other site 568703002256 putative triphosphate binding site [ion binding]; other site 568703002257 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 568703002258 synthetase active site [active] 568703002259 NTP binding site [chemical binding]; other site 568703002260 metal binding site [ion binding]; metal-binding site 568703002261 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 568703002262 ATP-NAD kinase; Region: NAD_kinase; pfam01513 568703002263 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703002264 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 568703002265 RNA binding surface [nucleotide binding]; other site 568703002266 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 568703002267 active site 568703002268 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 568703002269 ApbE family; Region: ApbE; pfam02424 568703002270 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 568703002271 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 568703002272 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 568703002273 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 568703002274 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 568703002275 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 568703002276 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 568703002277 active site 568703002278 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 568703002279 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 568703002280 Cl binding site [ion binding]; other site 568703002281 oligomer interface [polypeptide binding]; other site 568703002282 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 568703002283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703002284 S-adenosylmethionine binding site [chemical binding]; other site 568703002285 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 568703002286 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 568703002287 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 568703002288 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 568703002289 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 568703002290 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 568703002291 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 568703002292 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 568703002293 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 568703002294 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 568703002295 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 568703002296 classical (c) SDRs; Region: SDR_c; cd05233 568703002297 NAD(P) binding site [chemical binding]; other site 568703002298 active site 568703002299 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 568703002300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002301 non-specific DNA binding site [nucleotide binding]; other site 568703002302 salt bridge; other site 568703002303 sequence-specific DNA binding site [nucleotide binding]; other site 568703002304 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 568703002305 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 568703002306 competence damage-inducible protein A; Provisional; Region: PRK00549 568703002307 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 568703002308 putative MPT binding site; other site 568703002309 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 568703002310 recombinase A; Provisional; Region: recA; PRK09354 568703002311 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 568703002312 hexamer interface [polypeptide binding]; other site 568703002313 Walker A motif; other site 568703002314 ATP binding site [chemical binding]; other site 568703002315 Walker B motif; other site 568703002316 ribonuclease Y; Region: RNase_Y; TIGR03319 568703002317 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568703002318 Zn2+ binding site [ion binding]; other site 568703002319 Mg2+ binding site [ion binding]; other site 568703002320 Uncharacterized conserved protein [Function unknown]; Region: COG1739 568703002321 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 568703002322 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 568703002323 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 568703002324 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703002325 ATP binding site [chemical binding]; other site 568703002326 putative Mg++ binding site [ion binding]; other site 568703002327 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703002328 nucleotide binding region [chemical binding]; other site 568703002329 ATP-binding site [chemical binding]; other site 568703002330 comF family protein; Region: comF; TIGR00201 568703002331 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 568703002332 30S subunit binding site; other site 568703002333 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 568703002334 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 568703002335 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703002336 nucleotide binding region [chemical binding]; other site 568703002337 ATP-binding site [chemical binding]; other site 568703002338 peptide chain release factor 2; Provisional; Region: PRK05589 568703002339 This domain is found in peptide chain release factors; Region: PCRF; smart00937 568703002340 RF-1 domain; Region: RF-1; pfam00472 568703002341 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 568703002342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703002343 Walker A/P-loop; other site 568703002344 ATP binding site [chemical binding]; other site 568703002345 Q-loop/lid; other site 568703002346 ABC transporter signature motif; other site 568703002347 Walker B; other site 568703002348 D-loop; other site 568703002349 H-loop/switch region; other site 568703002350 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 568703002351 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 568703002352 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568703002353 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703002354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703002355 active site 568703002356 phosphorylation site [posttranslational modification] 568703002357 intermolecular recognition site; other site 568703002358 dimerization interface [polypeptide binding]; other site 568703002359 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703002360 DNA binding site [nucleotide binding] 568703002361 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 568703002362 PAS domain; Region: PAS_8; pfam13188 568703002363 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703002364 dimer interface [polypeptide binding]; other site 568703002365 phosphorylation site [posttranslational modification] 568703002366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703002367 ATP binding site [chemical binding]; other site 568703002368 Mg2+ binding site [ion binding]; other site 568703002369 G-X-G motif; other site 568703002370 phosphate binding protein; Region: ptsS_2; TIGR02136 568703002371 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 568703002372 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 568703002373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703002374 dimer interface [polypeptide binding]; other site 568703002375 conserved gate region; other site 568703002376 putative PBP binding loops; other site 568703002377 ABC-ATPase subunit interface; other site 568703002378 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 568703002379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703002380 dimer interface [polypeptide binding]; other site 568703002381 conserved gate region; other site 568703002382 putative PBP binding loops; other site 568703002383 ABC-ATPase subunit interface; other site 568703002384 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 568703002385 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 568703002386 Walker A/P-loop; other site 568703002387 ATP binding site [chemical binding]; other site 568703002388 Q-loop/lid; other site 568703002389 ABC transporter signature motif; other site 568703002390 Walker B; other site 568703002391 D-loop; other site 568703002392 H-loop/switch region; other site 568703002393 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14255 568703002394 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 568703002395 Walker A/P-loop; other site 568703002396 ATP binding site [chemical binding]; other site 568703002397 Q-loop/lid; other site 568703002398 ABC transporter signature motif; other site 568703002399 Walker B; other site 568703002400 D-loop; other site 568703002401 H-loop/switch region; other site 568703002402 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 568703002403 PhoU domain; Region: PhoU; pfam01895 568703002404 PhoU domain; Region: PhoU; pfam01895 568703002405 putative transposase OrfB; Reviewed; Region: PHA02517 568703002406 HTH-like domain; Region: HTH_21; pfam13276 568703002407 Integrase core domain; Region: rve; pfam00665 568703002408 Integrase core domain; Region: rve_3; pfam13683 568703002409 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703002410 Transposase; Region: HTH_Tnp_1; cl17663 568703002411 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568703002412 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703002413 Uncharacterized conserved protein [Function unknown]; Region: COG3595 568703002414 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 568703002415 Membrane protein of unknown function; Region: DUF360; pfam04020 568703002416 HPr kinase/phosphorylase; Provisional; Region: PRK05428 568703002417 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 568703002418 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 568703002419 Hpr binding site; other site 568703002420 active site 568703002421 homohexamer subunit interaction site [polypeptide binding]; other site 568703002422 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 568703002423 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 568703002424 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 568703002425 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 568703002426 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 568703002427 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568703002428 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703002429 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 568703002430 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 568703002431 active site 568703002432 substrate binding site [chemical binding]; other site 568703002433 metal binding site [ion binding]; metal-binding site 568703002434 HD domain; Region: HD_3; cl17350 568703002435 excinuclease ABC subunit B; Provisional; Region: PRK05298 568703002436 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 568703002437 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703002438 ATP-binding site [chemical binding]; other site 568703002439 ATP binding site [chemical binding]; other site 568703002440 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703002441 nucleotide binding region [chemical binding]; other site 568703002442 ATP-binding site [chemical binding]; other site 568703002443 Ultra-violet resistance protein B; Region: UvrB; pfam12344 568703002444 UvrB/uvrC motif; Region: UVR; pfam02151 568703002445 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 568703002446 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 568703002447 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 568703002448 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 568703002449 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 568703002450 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 568703002451 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 568703002452 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 568703002453 phosphate binding site [ion binding]; other site 568703002454 putative substrate binding pocket [chemical binding]; other site 568703002455 dimer interface [polypeptide binding]; other site 568703002456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 568703002457 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 568703002458 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568703002459 MarR family; Region: MarR; pfam01047 568703002460 Clp protease; Region: CLP_protease; pfam00574 568703002461 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 568703002462 oligomer interface [polypeptide binding]; other site 568703002463 active site residues [active] 568703002464 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 568703002465 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 568703002466 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 568703002467 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 568703002468 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 568703002469 Phosphoglycerate kinase; Region: PGK; pfam00162 568703002470 substrate binding site [chemical binding]; other site 568703002471 hinge regions; other site 568703002472 ADP binding site [chemical binding]; other site 568703002473 catalytic site [active] 568703002474 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 568703002475 triosephosphate isomerase; Provisional; Region: PRK14567 568703002476 substrate binding site [chemical binding]; other site 568703002477 dimer interface [polypeptide binding]; other site 568703002478 catalytic triad [active] 568703002479 enolase; Provisional; Region: eno; PRK00077 568703002480 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 568703002481 dimer interface [polypeptide binding]; other site 568703002482 metal binding site [ion binding]; metal-binding site 568703002483 substrate binding pocket [chemical binding]; other site 568703002484 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 568703002485 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 568703002486 Cl- selectivity filter; other site 568703002487 Cl- binding residues [ion binding]; other site 568703002488 pore gating glutamate residue; other site 568703002489 dimer interface [polypeptide binding]; other site 568703002490 H+/Cl- coupling transport residue; other site 568703002491 TrkA-C domain; Region: TrkA_C; pfam02080 568703002492 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 568703002493 Esterase/lipase [General function prediction only]; Region: COG1647 568703002494 ribonuclease R; Region: RNase_R; TIGR02063 568703002495 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 568703002496 RNB domain; Region: RNB; pfam00773 568703002497 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 568703002498 RNA binding site [nucleotide binding]; other site 568703002499 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 568703002500 SmpB-tmRNA interface; other site 568703002501 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 568703002502 homodimer interface [polypeptide binding]; other site 568703002503 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 568703002504 active site 568703002505 homodimer interface [polypeptide binding]; other site 568703002506 catalytic site [active] 568703002507 maltose phosphorylase; Provisional; Region: PRK13807 568703002508 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 568703002509 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 568703002510 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 568703002511 beta-phosphoglucomutase; Region: bPGM; TIGR01990 568703002512 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 568703002513 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703002514 motif II; other site 568703002515 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002516 sequence-specific DNA binding site [nucleotide binding]; other site 568703002517 salt bridge; other site 568703002518 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 568703002519 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 568703002520 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 568703002521 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 568703002522 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568703002523 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568703002524 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568703002525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703002526 dimer interface [polypeptide binding]; other site 568703002527 conserved gate region; other site 568703002528 putative PBP binding loops; other site 568703002529 ABC-ATPase subunit interface; other site 568703002530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703002531 dimer interface [polypeptide binding]; other site 568703002532 conserved gate region; other site 568703002533 putative PBP binding loops; other site 568703002534 ABC-ATPase subunit interface; other site 568703002535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703002536 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 568703002537 Walker A/P-loop; other site 568703002538 ATP binding site [chemical binding]; other site 568703002539 Q-loop/lid; other site 568703002540 ABC transporter signature motif; other site 568703002541 Walker B; other site 568703002542 D-loop; other site 568703002543 H-loop/switch region; other site 568703002544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703002545 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 568703002546 Coenzyme A binding pocket [chemical binding]; other site 568703002547 Tubby C 2; Region: Tub_2; cl02043 568703002548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703002549 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703002550 active site 568703002551 motif I; other site 568703002552 motif II; other site 568703002553 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 568703002554 ligand binding site [chemical binding]; other site 568703002555 active site 568703002556 UGI interface [polypeptide binding]; other site 568703002557 catalytic site [active] 568703002558 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 568703002559 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 568703002560 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 568703002561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703002562 Walker A/P-loop; other site 568703002563 ATP binding site [chemical binding]; other site 568703002564 Q-loop/lid; other site 568703002565 ABC transporter signature motif; other site 568703002566 Walker B; other site 568703002567 D-loop; other site 568703002568 H-loop/switch region; other site 568703002569 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 568703002570 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 568703002571 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 568703002572 active site 568703002573 catalytic site [active] 568703002574 substrate binding site [chemical binding]; other site 568703002575 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 568703002576 active site 568703002577 putative catalytic site [active] 568703002578 DNA binding site [nucleotide binding] 568703002579 putative phosphate binding site [ion binding]; other site 568703002580 metal binding site A [ion binding]; metal-binding site 568703002581 AP binding site [nucleotide binding]; other site 568703002582 metal binding site B [ion binding]; metal-binding site 568703002583 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 568703002584 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 568703002585 FAD binding domain; Region: FAD_binding_4; pfam01565 568703002586 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 568703002587 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 568703002588 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703002589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002590 non-specific DNA binding site [nucleotide binding]; other site 568703002591 salt bridge; other site 568703002592 sequence-specific DNA binding site [nucleotide binding]; other site 568703002593 Cupin domain; Region: Cupin_2; pfam07883 568703002594 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 568703002595 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 568703002596 Walker A/P-loop; other site 568703002597 ATP binding site [chemical binding]; other site 568703002598 Q-loop/lid; other site 568703002599 ABC transporter signature motif; other site 568703002600 Walker B; other site 568703002601 D-loop; other site 568703002602 H-loop/switch region; other site 568703002603 TOBE domain; Region: TOBE_2; pfam08402 568703002604 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568703002605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703002606 dimer interface [polypeptide binding]; other site 568703002607 conserved gate region; other site 568703002608 putative PBP binding loops; other site 568703002609 ABC-ATPase subunit interface; other site 568703002610 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568703002611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703002612 dimer interface [polypeptide binding]; other site 568703002613 conserved gate region; other site 568703002614 putative PBP binding loops; other site 568703002615 ABC-ATPase subunit interface; other site 568703002616 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 568703002617 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568703002618 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 568703002619 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 568703002620 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703002621 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 568703002622 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703002623 motif II; other site 568703002624 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568703002625 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703002626 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703002627 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 568703002628 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 568703002629 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 568703002630 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703002631 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 568703002632 Walker A/P-loop; other site 568703002633 ATP binding site [chemical binding]; other site 568703002634 Q-loop/lid; other site 568703002635 ABC transporter signature motif; other site 568703002636 Walker B; other site 568703002637 D-loop; other site 568703002638 H-loop/switch region; other site 568703002639 Uncharacterized conserved protein [Function unknown]; Region: COG1624 568703002640 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 568703002641 YbbR-like protein; Region: YbbR; pfam07949 568703002642 YbbR-like protein; Region: YbbR; pfam07949 568703002643 YbbR-like protein; Region: YbbR; pfam07949 568703002644 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 568703002645 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 568703002646 active site 568703002647 substrate binding site [chemical binding]; other site 568703002648 metal binding site [ion binding]; metal-binding site 568703002649 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 568703002650 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 568703002651 glutaminase active site [active] 568703002652 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 568703002653 dimer interface [polypeptide binding]; other site 568703002654 active site 568703002655 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 568703002656 dimer interface [polypeptide binding]; other site 568703002657 active site 568703002658 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 568703002659 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 568703002660 active site 568703002661 Zn binding site [ion binding]; other site 568703002662 Predicted integral membrane protein [Function unknown]; Region: COG5652 568703002663 hypothetical protein; Validated; Region: PRK00110 568703002664 Type II/IV secretion system protein; Region: T2SE; pfam00437 568703002665 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 568703002666 Walker A motif; other site 568703002667 ATP binding site [chemical binding]; other site 568703002668 Walker B motif; other site 568703002669 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 568703002670 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 568703002671 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 568703002672 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 568703002673 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 568703002674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703002675 S-adenosylmethionine binding site [chemical binding]; other site 568703002676 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 568703002677 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 568703002678 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 568703002679 putative acyl-acceptor binding pocket; other site 568703002680 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568703002681 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 568703002682 active site 568703002683 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 568703002684 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 568703002685 Ligand binding site; other site 568703002686 metal-binding site 568703002687 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 568703002688 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 568703002689 putative acyl-acceptor binding pocket; other site 568703002690 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 568703002691 Melibiase; Region: Melibiase; pfam02065 568703002692 SdpI/YhfL protein family; Region: SdpI; pfam13630 568703002693 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703002694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703002695 active site 568703002696 phosphorylation site [posttranslational modification] 568703002697 intermolecular recognition site; other site 568703002698 dimerization interface [polypeptide binding]; other site 568703002699 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703002700 DNA binding site [nucleotide binding] 568703002701 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703002702 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568703002703 dimerization interface [polypeptide binding]; other site 568703002704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703002705 dimer interface [polypeptide binding]; other site 568703002706 phosphorylation site [posttranslational modification] 568703002707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703002708 ATP binding site [chemical binding]; other site 568703002709 Mg2+ binding site [ion binding]; other site 568703002710 G-X-G motif; other site 568703002711 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 568703002712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703002713 Coenzyme A binding pocket [chemical binding]; other site 568703002714 hypothetical protein; Provisional; Region: PRK04435 568703002715 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 568703002716 DNA-binding interface [nucleotide binding]; DNA binding site 568703002717 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 568703002718 DNA polymerase IV; Reviewed; Region: PRK03103 568703002719 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 568703002720 active site 568703002721 DNA binding site [nucleotide binding] 568703002722 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 568703002723 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 568703002724 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 568703002725 active site 568703002726 catalytic triad [active] 568703002727 oxyanion hole [active] 568703002728 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 568703002729 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 568703002730 Part of AAA domain; Region: AAA_19; pfam13245 568703002731 Family description; Region: UvrD_C_2; pfam13538 568703002732 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 568703002733 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 568703002734 nucleotide binding pocket [chemical binding]; other site 568703002735 K-X-D-G motif; other site 568703002736 catalytic site [active] 568703002737 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 568703002738 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 568703002739 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 568703002740 Dimer interface [polypeptide binding]; other site 568703002741 BRCT sequence motif; other site 568703002742 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 568703002743 putative dimer interface [polypeptide binding]; other site 568703002744 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 568703002745 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 568703002746 putative dimer interface [polypeptide binding]; other site 568703002747 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 568703002748 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 568703002749 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 568703002750 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 568703002751 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 568703002752 GatB domain; Region: GatB_Yqey; smart00845 568703002753 putative lipid kinase; Reviewed; Region: PRK13055 568703002754 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 568703002755 TRAM domain; Region: TRAM; pfam01938 568703002756 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 568703002757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703002758 S-adenosylmethionine binding site [chemical binding]; other site 568703002759 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 568703002760 DNA methylase; Region: N6_N4_Mtase; pfam01555 568703002761 DNA methylase; Region: N6_N4_Mtase; cl17433 568703002762 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 568703002763 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 568703002764 Transposase domain (DUF772); Region: DUF772; pfam05598 568703002765 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703002766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002767 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703002768 putative substrate translocation pore; other site 568703002769 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703002770 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703002771 active site 568703002772 motif I; other site 568703002773 motif II; other site 568703002774 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 568703002775 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 568703002776 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 568703002777 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 568703002778 active site 568703002779 Zn binding site [ion binding]; other site 568703002780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703002781 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 568703002782 Coenzyme A binding pocket [chemical binding]; other site 568703002783 EDD domain protein, DegV family; Region: DegV; TIGR00762 568703002784 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 568703002785 HflC protein; Region: hflC; TIGR01932 568703002786 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 568703002787 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 568703002788 active site 568703002789 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 568703002790 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 568703002791 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568703002792 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568703002793 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 568703002794 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 568703002795 ATP binding site [chemical binding]; other site 568703002796 putative Mg++ binding site [ion binding]; other site 568703002797 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703002798 nucleotide binding region [chemical binding]; other site 568703002799 ATP-binding site [chemical binding]; other site 568703002800 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 568703002801 active site 568703002802 methionine cluster; other site 568703002803 phosphorylation site [posttranslational modification] 568703002804 metal binding site [ion binding]; metal-binding site 568703002805 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 568703002806 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 568703002807 active site 568703002808 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 568703002809 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703002810 ATP binding site [chemical binding]; other site 568703002811 putative Mg++ binding site [ion binding]; other site 568703002812 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703002813 nucleotide binding region [chemical binding]; other site 568703002814 ATP-binding site [chemical binding]; other site 568703002815 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 568703002816 HRDC domain; Region: HRDC; pfam00570 568703002817 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 568703002818 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 568703002819 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703002820 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703002821 WHG domain; Region: WHG; pfam13305 568703002822 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 568703002823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 568703002824 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 568703002825 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 568703002826 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 568703002827 active site 568703002828 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 568703002829 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 568703002830 active site 568703002831 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 568703002832 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 568703002833 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 568703002834 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 568703002835 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 568703002836 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 568703002837 active site 568703002838 tetramer interface; other site 568703002839 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 568703002840 beta-galactosidase; Region: BGL; TIGR03356 568703002841 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 568703002842 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 568703002843 active site turn [active] 568703002844 phosphorylation site [posttranslational modification] 568703002845 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568703002846 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 568703002847 HPr interaction site; other site 568703002848 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568703002849 active site 568703002850 phosphorylation site [posttranslational modification] 568703002851 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 568703002852 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 568703002853 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 568703002854 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 568703002855 Ligand binding site; other site 568703002856 Putative Catalytic site; other site 568703002857 DXD motif; other site 568703002858 Predicted membrane protein [Function unknown]; Region: COG4129 568703002859 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 568703002860 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 568703002861 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568703002862 DNA-binding site [nucleotide binding]; DNA binding site 568703002863 RNA-binding motif; other site 568703002864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 568703002865 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 568703002866 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703002867 active site 568703002868 xanthine permease; Region: pbuX; TIGR03173 568703002869 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 568703002870 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568703002871 adenylosuccinate lyase; Provisional; Region: PRK07492 568703002872 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 568703002873 tetramer interface [polypeptide binding]; other site 568703002874 active site 568703002875 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 568703002876 Sulfatase; Region: Sulfatase; pfam00884 568703002877 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 568703002878 Sugar transport protein; Region: Sugar_transport; pfam06800 568703002879 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 568703002880 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 568703002881 active site 568703002882 dimer interface [polypeptide binding]; other site 568703002883 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 568703002884 dimer interface [polypeptide binding]; other site 568703002885 active site 568703002886 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 568703002887 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 568703002888 Int/Topo IB signature motif; other site 568703002889 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 568703002890 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 568703002891 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703002892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002893 non-specific DNA binding site [nucleotide binding]; other site 568703002894 salt bridge; other site 568703002895 sequence-specific DNA binding site [nucleotide binding]; other site 568703002896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002897 non-specific DNA binding site [nucleotide binding]; other site 568703002898 salt bridge; other site 568703002899 sequence-specific DNA binding site [nucleotide binding]; other site 568703002900 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 568703002901 RecT family; Region: RecT; pfam03837 568703002902 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 568703002903 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 568703002904 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 568703002905 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 568703002906 dimer interface [polypeptide binding]; other site 568703002907 ssDNA binding site [nucleotide binding]; other site 568703002908 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703002909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002910 non-specific DNA binding site [nucleotide binding]; other site 568703002911 salt bridge; other site 568703002912 sequence-specific DNA binding site [nucleotide binding]; other site 568703002913 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 568703002914 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 568703002915 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 568703002916 GcrA cell cycle regulator; Region: GcrA; cl11564 568703002917 NUMOD4 motif; Region: NUMOD4; pfam07463 568703002918 HNH endonuclease; Region: HNH_3; pfam13392 568703002919 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 568703002920 Terminase small subunit; Region: Terminase_2; pfam03592 568703002921 Phage terminase large subunit; Region: Terminase_3; cl12054 568703002922 Terminase-like family; Region: Terminase_6; pfam03237 568703002923 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 568703002924 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 568703002925 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 568703002926 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 568703002927 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 568703002928 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 568703002929 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 568703002930 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 568703002931 Phage protein; Region: DUF3647; pfam12363 568703002932 Phage-related protein [Function unknown]; Region: COG5412 568703002933 Phage tail protein; Region: Sipho_tail; pfam05709 568703002934 Phage tail protein; Region: Sipho_tail; cl17486 568703002935 Phage tail protein; Region: Sipho_tail; cl17486 568703002936 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 568703002937 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 568703002938 Bacteriophage holin; Region: Phage_holin_1; pfam04531 568703002939 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 568703002940 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 568703002941 active site 568703002942 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568703002943 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568703002944 Uncharacterized conserved protein [Function unknown]; Region: COG1359 568703002945 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 568703002946 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 568703002947 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568703002948 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703002949 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568703002950 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568703002951 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 568703002952 nucleoside/Zn binding site; other site 568703002953 dimer interface [polypeptide binding]; other site 568703002954 catalytic motif [active] 568703002955 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 568703002956 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703002957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002958 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703002959 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703002960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002961 Peptidase family C69; Region: Peptidase_C69; pfam03577 568703002962 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 568703002963 catalytic core [active] 568703002964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703002965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703002966 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703002967 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703002968 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703002969 Walker A/P-loop; other site 568703002970 ATP binding site [chemical binding]; other site 568703002971 Q-loop/lid; other site 568703002972 ABC transporter signature motif; other site 568703002973 Walker B; other site 568703002974 D-loop; other site 568703002975 H-loop/switch region; other site 568703002976 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703002977 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703002978 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 568703002979 Walker A/P-loop; other site 568703002980 ATP binding site [chemical binding]; other site 568703002981 Q-loop/lid; other site 568703002982 ABC transporter signature motif; other site 568703002983 Walker B; other site 568703002984 D-loop; other site 568703002985 H-loop/switch region; other site 568703002986 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 568703002987 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 568703002988 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 568703002989 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 568703002990 active site 568703002991 metal binding site [ion binding]; metal-binding site 568703002992 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 568703002993 active site 568703002994 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568703002995 Beta-lactamase; Region: Beta-lactamase; pfam00144 568703002996 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 568703002997 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568703002998 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 568703002999 thymidine kinase; Provisional; Region: PRK04296 568703003000 peptide chain release factor 1; Validated; Region: prfA; PRK00591 568703003001 This domain is found in peptide chain release factors; Region: PCRF; smart00937 568703003002 RF-1 domain; Region: RF-1; pfam00472 568703003003 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 568703003004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703003005 S-adenosylmethionine binding site [chemical binding]; other site 568703003006 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 568703003007 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 568703003008 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 568703003009 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 568703003010 dimer interface [polypeptide binding]; other site 568703003011 active site 568703003012 glycine-pyridoxal phosphate binding site [chemical binding]; other site 568703003013 folate binding site [chemical binding]; other site 568703003014 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703003015 active site 568703003016 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 568703003017 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 568703003018 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 568703003019 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 568703003020 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 568703003021 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 568703003022 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 568703003023 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 568703003024 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 568703003025 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 568703003026 beta subunit interaction interface [polypeptide binding]; other site 568703003027 Walker A motif; other site 568703003028 ATP binding site [chemical binding]; other site 568703003029 Walker B motif; other site 568703003030 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 568703003031 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 568703003032 core domain interface [polypeptide binding]; other site 568703003033 delta subunit interface [polypeptide binding]; other site 568703003034 epsilon subunit interface [polypeptide binding]; other site 568703003035 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 568703003036 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 568703003037 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 568703003038 alpha subunit interaction interface [polypeptide binding]; other site 568703003039 Walker A motif; other site 568703003040 ATP binding site [chemical binding]; other site 568703003041 Walker B motif; other site 568703003042 inhibitor binding site; inhibition site 568703003043 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 568703003044 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 568703003045 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 568703003046 gamma subunit interface [polypeptide binding]; other site 568703003047 epsilon subunit interface [polypeptide binding]; other site 568703003048 LBP interface [polypeptide binding]; other site 568703003049 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 568703003050 rod shape-determining protein MreB; Provisional; Region: PRK13930 568703003051 MreB and similar proteins; Region: MreB_like; cd10225 568703003052 nucleotide binding site [chemical binding]; other site 568703003053 Mg binding site [ion binding]; other site 568703003054 putative protofilament interaction site [polypeptide binding]; other site 568703003055 RodZ interaction site [polypeptide binding]; other site 568703003056 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 568703003057 Haemolytic domain; Region: Haemolytic; cl00506 568703003058 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 568703003059 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 568703003060 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 568703003061 lipoyl attachment site [posttranslational modification]; other site 568703003062 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 568703003063 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 568703003064 metal binding site [ion binding]; metal-binding site 568703003065 dimer interface [polypeptide binding]; other site 568703003066 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 568703003067 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 568703003068 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 568703003069 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 568703003070 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 568703003071 Walker A/P-loop; other site 568703003072 ATP binding site [chemical binding]; other site 568703003073 Q-loop/lid; other site 568703003074 ABC transporter signature motif; other site 568703003075 Walker B; other site 568703003076 D-loop; other site 568703003077 H-loop/switch region; other site 568703003078 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 568703003079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703003080 dimer interface [polypeptide binding]; other site 568703003081 conserved gate region; other site 568703003082 ABC-ATPase subunit interface; other site 568703003083 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 568703003084 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 568703003085 Walker A/P-loop; other site 568703003086 ATP binding site [chemical binding]; other site 568703003087 Q-loop/lid; other site 568703003088 ABC transporter signature motif; other site 568703003089 Walker B; other site 568703003090 D-loop; other site 568703003091 H-loop/switch region; other site 568703003092 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 568703003093 FeS assembly protein SufD; Region: sufD; TIGR01981 568703003094 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 568703003095 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 568703003096 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703003097 catalytic residue [active] 568703003098 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 568703003099 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 568703003100 trimerization site [polypeptide binding]; other site 568703003101 active site 568703003102 FeS assembly protein SufB; Region: sufB; TIGR01980 568703003103 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 568703003104 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 568703003105 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 568703003106 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703003107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703003108 non-specific DNA binding site [nucleotide binding]; other site 568703003109 salt bridge; other site 568703003110 sequence-specific DNA binding site [nucleotide binding]; other site 568703003111 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568703003112 Ligand Binding Site [chemical binding]; other site 568703003113 recombination factor protein RarA; Reviewed; Region: PRK13342 568703003114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703003115 Walker A motif; other site 568703003116 ATP binding site [chemical binding]; other site 568703003117 Walker B motif; other site 568703003118 arginine finger; other site 568703003119 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 568703003120 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 568703003121 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 568703003122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 568703003123 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 568703003124 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 568703003125 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 568703003126 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 568703003127 putative L-serine binding site [chemical binding]; other site 568703003128 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 568703003129 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 568703003130 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703003131 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 568703003132 catalytic core [active] 568703003133 Enterocin A Immunity; Region: EntA_Immun; pfam08951 568703003134 methionine sulfoxide reductase A; Provisional; Region: PRK14054 568703003135 short chain dehydrogenase; Provisional; Region: PRK06197 568703003136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703003137 NAD(P) binding site [chemical binding]; other site 568703003138 active site 568703003139 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 568703003140 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 568703003141 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 568703003142 active site 568703003143 hypothetical protein; Provisional; Region: PRK07329 568703003144 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 568703003145 active site 568703003146 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568703003147 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568703003148 peptide binding site [polypeptide binding]; other site 568703003149 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703003150 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703003151 dimer interface [polypeptide binding]; other site 568703003152 phosphorylation site [posttranslational modification] 568703003153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703003154 ATP binding site [chemical binding]; other site 568703003155 Mg2+ binding site [ion binding]; other site 568703003156 G-X-G motif; other site 568703003157 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703003158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703003159 active site 568703003160 phosphorylation site [posttranslational modification] 568703003161 intermolecular recognition site; other site 568703003162 dimerization interface [polypeptide binding]; other site 568703003163 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703003164 DNA binding site [nucleotide binding] 568703003165 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703003166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703003167 Walker A/P-loop; other site 568703003168 ATP binding site [chemical binding]; other site 568703003169 Q-loop/lid; other site 568703003170 ABC transporter signature motif; other site 568703003171 Walker B; other site 568703003172 D-loop; other site 568703003173 H-loop/switch region; other site 568703003174 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703003175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703003176 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703003177 dimerization interface [polypeptide binding]; other site 568703003178 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 568703003179 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 568703003180 SAP domain; Region: SAP; cl02640 568703003181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703003182 Coenzyme A binding pocket [chemical binding]; other site 568703003183 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703003184 Coenzyme A binding pocket [chemical binding]; other site 568703003185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703003186 Coenzyme A binding pocket [chemical binding]; other site 568703003187 EDD domain protein, DegV family; Region: DegV; TIGR00762 568703003188 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 568703003189 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568703003190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703003191 active site 568703003192 phosphorylation site [posttranslational modification] 568703003193 intermolecular recognition site; other site 568703003194 dimerization interface [polypeptide binding]; other site 568703003195 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568703003196 DNA binding residues [nucleotide binding] 568703003197 dimerization interface [polypeptide binding]; other site 568703003198 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 568703003199 Histidine kinase; Region: HisKA_3; pfam07730 568703003200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703003201 ATP binding site [chemical binding]; other site 568703003202 Mg2+ binding site [ion binding]; other site 568703003203 G-X-G motif; other site 568703003204 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 568703003205 ABC-2 type transporter; Region: ABC2_membrane; cl17235 568703003206 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703003207 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703003208 Walker A/P-loop; other site 568703003209 ATP binding site [chemical binding]; other site 568703003210 Q-loop/lid; other site 568703003211 ABC transporter signature motif; other site 568703003212 Walker B; other site 568703003213 D-loop; other site 568703003214 H-loop/switch region; other site 568703003215 TIGR02680 family protein; Region: TIGR02680 568703003216 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 568703003217 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 568703003218 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 568703003219 Transposase domain (DUF772); Region: DUF772; pfam05598 568703003220 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703003221 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 568703003222 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 568703003223 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 568703003224 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 568703003225 RNA binding site [nucleotide binding]; other site 568703003226 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 568703003227 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 568703003228 catalytic triad [active] 568703003229 amino acid transporter; Region: 2A0306; TIGR00909 568703003230 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703003231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703003232 non-specific DNA binding site [nucleotide binding]; other site 568703003233 salt bridge; other site 568703003234 sequence-specific DNA binding site [nucleotide binding]; other site 568703003235 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 568703003236 G1 box; other site 568703003237 GTP/Mg2+ binding site [chemical binding]; other site 568703003238 G2 box; other site 568703003239 Switch I region; other site 568703003240 G3 box; other site 568703003241 Switch II region; other site 568703003242 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 568703003243 AAA domain; Region: AAA_12; pfam13087 568703003244 C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118 568703003245 PLD-like domain; Region: PLDc_2; pfam13091 568703003246 putative active site [active] 568703003247 catalytic site [active] 568703003248 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 568703003249 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 568703003250 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703003251 RNA binding surface [nucleotide binding]; other site 568703003252 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 568703003253 GAF domain; Region: GAF_2; pfam13185 568703003254 septation ring formation regulator EzrA; Provisional; Region: PRK04778 568703003255 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 568703003256 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 568703003257 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703003258 catalytic residue [active] 568703003259 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 568703003260 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 568703003261 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 568703003262 Ligand Binding Site [chemical binding]; other site 568703003263 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 568703003264 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 568703003265 CoA binding domain; Region: CoA_binding; pfam02629 568703003266 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 568703003267 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568703003268 active site 568703003269 HIGH motif; other site 568703003270 nucleotide binding site [chemical binding]; other site 568703003271 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 568703003272 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 568703003273 active site 568703003274 KMSKS motif; other site 568703003275 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 568703003276 tRNA binding surface [nucleotide binding]; other site 568703003277 anticodon binding site; other site 568703003278 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 568703003279 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 568703003280 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568703003281 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 568703003282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703003283 motif II; other site 568703003284 hypothetical protein; Reviewed; Region: PRK00024 568703003285 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 568703003286 MPN+ (JAMM) motif; other site 568703003287 Zinc-binding site [ion binding]; other site 568703003288 rod shape-determining protein MreB; Provisional; Region: PRK13927 568703003289 MreB and similar proteins; Region: MreB_like; cd10225 568703003290 nucleotide binding site [chemical binding]; other site 568703003291 Mg binding site [ion binding]; other site 568703003292 putative protofilament interaction site [polypeptide binding]; other site 568703003293 RodZ interaction site [polypeptide binding]; other site 568703003294 rod shape-determining protein MreC; Provisional; Region: PRK13922 568703003295 Protein of unknown function (DUF904); Region: DUF904; pfam06005 568703003296 rod shape-determining protein MreC; Region: MreC; pfam04085 568703003297 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 568703003298 septum formation inhibitor; Reviewed; Region: minC; PRK00513 568703003299 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 568703003300 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 568703003301 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 568703003302 Switch I; other site 568703003303 Switch II; other site 568703003304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703003305 dimer interface [polypeptide binding]; other site 568703003306 conserved gate region; other site 568703003307 putative PBP binding loops; other site 568703003308 ABC-ATPase subunit interface; other site 568703003309 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703003310 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703003311 Walker A/P-loop; other site 568703003312 ATP binding site [chemical binding]; other site 568703003313 Q-loop/lid; other site 568703003314 ABC transporter signature motif; other site 568703003315 Walker B; other site 568703003316 D-loop; other site 568703003317 H-loop/switch region; other site 568703003318 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703003319 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703003320 substrate binding pocket [chemical binding]; other site 568703003321 membrane-bound complex binding site; other site 568703003322 hinge residues; other site 568703003323 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 568703003324 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 568703003325 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 568703003326 putative active site [active] 568703003327 catalytic site [active] 568703003328 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 568703003329 putative active site [active] 568703003330 catalytic site [active] 568703003331 cell division protein MraZ; Reviewed; Region: PRK00326 568703003332 MraZ protein; Region: MraZ; pfam02381 568703003333 MraZ protein; Region: MraZ; pfam02381 568703003334 MraW methylase family; Region: Methyltransf_5; pfam01795 568703003335 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 568703003336 Cell division protein FtsL; Region: FtsL; cl11433 568703003337 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 568703003338 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 568703003339 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568703003340 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 568703003341 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 568703003342 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 568703003343 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 568703003344 Mg++ binding site [ion binding]; other site 568703003345 putative catalytic motif [active] 568703003346 putative substrate binding site [chemical binding]; other site 568703003347 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 568703003348 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 568703003349 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568703003350 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568703003351 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 568703003352 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 568703003353 active site 568703003354 homodimer interface [polypeptide binding]; other site 568703003355 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 568703003356 Cell division protein FtsQ; Region: FtsQ; pfam03799 568703003357 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 568703003358 Cell division protein FtsA; Region: FtsA; smart00842 568703003359 Cell division protein FtsA; Region: FtsA; pfam14450 568703003360 cell division protein FtsZ; Validated; Region: PRK09330 568703003361 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 568703003362 nucleotide binding site [chemical binding]; other site 568703003363 SulA interaction site; other site 568703003364 Protein of unknown function (DUF552); Region: DUF552; pfam04472 568703003365 YGGT family; Region: YGGT; pfam02325 568703003366 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 568703003367 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703003368 RNA binding surface [nucleotide binding]; other site 568703003369 DivIVA protein; Region: DivIVA; pfam05103 568703003370 DivIVA domain; Region: DivI1A_domain; TIGR03544 568703003371 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 568703003372 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 568703003373 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568703003374 active site 568703003375 HIGH motif; other site 568703003376 nucleotide binding site [chemical binding]; other site 568703003377 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 568703003378 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 568703003379 active site 568703003380 KMSKS motif; other site 568703003381 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 568703003382 tRNA binding surface [nucleotide binding]; other site 568703003383 anticodon binding site; other site 568703003384 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 568703003385 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568703003386 DNA-binding site [nucleotide binding]; DNA binding site 568703003387 RNA-binding motif; other site 568703003388 PBP superfamily domain; Region: PBP_like_2; cl17296 568703003389 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 568703003390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703003391 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703003392 putative substrate translocation pore; other site 568703003393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703003394 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 568703003395 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 568703003396 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 568703003397 dimer interface [polypeptide binding]; other site 568703003398 ADP-ribose binding site [chemical binding]; other site 568703003399 active site 568703003400 nudix motif; other site 568703003401 metal binding site [ion binding]; metal-binding site 568703003402 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 568703003403 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 568703003404 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 568703003405 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 568703003406 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703003407 catalytic residue [active] 568703003408 Putative amino acid metabolism; Region: DUF1831; pfam08866 568703003409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703003410 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 568703003411 Walker A/P-loop; other site 568703003412 ATP binding site [chemical binding]; other site 568703003413 Q-loop/lid; other site 568703003414 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703003415 ABC transporter signature motif; other site 568703003416 Walker B; other site 568703003417 D-loop; other site 568703003418 H-loop/switch region; other site 568703003419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703003420 Walker A/P-loop; other site 568703003421 ATP binding site [chemical binding]; other site 568703003422 Q-loop/lid; other site 568703003423 ABC transporter signature motif; other site 568703003424 Walker B; other site 568703003425 D-loop; other site 568703003426 H-loop/switch region; other site 568703003427 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 568703003428 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 568703003429 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703003430 catalytic core [active] 568703003431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568703003432 binding surface 568703003433 TPR motif; other site 568703003434 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 568703003435 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 568703003436 AAA domain; Region: AAA_30; pfam13604 568703003437 Family description; Region: UvrD_C_2; pfam13538 568703003438 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 568703003439 Sterol carrier protein domain; Region: SCP2_2; pfam13530 568703003440 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 568703003441 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 568703003442 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 568703003443 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 568703003444 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 568703003445 hypothetical protein; Provisional; Region: PRK13667 568703003446 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 568703003447 active site 568703003448 catalytic residues [active] 568703003449 metal binding site [ion binding]; metal-binding site 568703003450 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703003451 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 568703003452 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 568703003453 TPP-binding site [chemical binding]; other site 568703003454 tetramer interface [polypeptide binding]; other site 568703003455 heterodimer interface [polypeptide binding]; other site 568703003456 phosphorylation loop region [posttranslational modification] 568703003457 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 568703003458 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 568703003459 alpha subunit interface [polypeptide binding]; other site 568703003460 TPP binding site [chemical binding]; other site 568703003461 heterodimer interface [polypeptide binding]; other site 568703003462 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568703003463 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 568703003464 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568703003465 E3 interaction surface; other site 568703003466 lipoyl attachment site [posttranslational modification]; other site 568703003467 e3 binding domain; Region: E3_binding; pfam02817 568703003468 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 568703003469 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 568703003470 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 568703003471 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703003472 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568703003473 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 568703003474 substrate binding site [chemical binding]; other site 568703003475 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 568703003476 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 568703003477 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 568703003478 active site 568703003479 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 568703003480 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 568703003481 G1 box; other site 568703003482 putative GEF interaction site [polypeptide binding]; other site 568703003483 GTP/Mg2+ binding site [chemical binding]; other site 568703003484 Switch I region; other site 568703003485 G2 box; other site 568703003486 G3 box; other site 568703003487 Switch II region; other site 568703003488 G4 box; other site 568703003489 G5 box; other site 568703003490 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 568703003491 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 568703003492 cell division protein FtsW; Region: ftsW; TIGR02614 568703003493 pyruvate carboxylase; Reviewed; Region: PRK12999 568703003494 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568703003495 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 568703003496 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 568703003497 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 568703003498 active site 568703003499 catalytic residues [active] 568703003500 metal binding site [ion binding]; metal-binding site 568703003501 homodimer binding site [polypeptide binding]; other site 568703003502 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568703003503 carboxyltransferase (CT) interaction site; other site 568703003504 biotinylation site [posttranslational modification]; other site 568703003505 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 568703003506 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 568703003507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703003508 S-adenosylmethionine binding site [chemical binding]; other site 568703003509 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 568703003510 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 568703003511 active site 568703003512 (T/H)XGH motif; other site 568703003513 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 568703003514 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 568703003515 protein binding site [polypeptide binding]; other site 568703003516 SLBB domain; Region: SLBB; pfam10531 568703003517 comEA protein; Region: comE; TIGR01259 568703003518 Helix-hairpin-helix motif; Region: HHH; pfam00633 568703003519 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 568703003520 Competence protein; Region: Competence; pfam03772 568703003521 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 568703003522 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 568703003523 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 568703003524 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 568703003525 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 568703003526 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 568703003527 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 568703003528 16S/18S rRNA binding site [nucleotide binding]; other site 568703003529 S13e-L30e interaction site [polypeptide binding]; other site 568703003530 25S rRNA binding site [nucleotide binding]; other site 568703003531 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 568703003532 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 568703003533 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 568703003534 elongation factor Tu; Reviewed; Region: PRK00049 568703003535 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 568703003536 G1 box; other site 568703003537 GEF interaction site [polypeptide binding]; other site 568703003538 GTP/Mg2+ binding site [chemical binding]; other site 568703003539 Switch I region; other site 568703003540 G2 box; other site 568703003541 G3 box; other site 568703003542 Switch II region; other site 568703003543 G4 box; other site 568703003544 G5 box; other site 568703003545 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 568703003546 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 568703003547 Antibiotic Binding Site [chemical binding]; other site 568703003548 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 568703003549 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 568703003550 NAD-dependent deacetylase; Provisional; Region: PRK00481 568703003551 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 568703003552 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 568703003553 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 568703003554 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 568703003555 DNA binding residues [nucleotide binding] 568703003556 putative dimer interface [polypeptide binding]; other site 568703003557 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703003558 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703003559 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 568703003560 Walker A/P-loop; other site 568703003561 ATP binding site [chemical binding]; other site 568703003562 Q-loop/lid; other site 568703003563 ABC transporter signature motif; other site 568703003564 Walker B; other site 568703003565 D-loop; other site 568703003566 H-loop/switch region; other site 568703003567 trigger factor; Provisional; Region: tig; PRK01490 568703003568 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 568703003569 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 568703003570 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 568703003571 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 568703003572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703003573 Walker A motif; other site 568703003574 ATP binding site [chemical binding]; other site 568703003575 Walker B motif; other site 568703003576 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 568703003577 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 568703003578 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 568703003579 G1 box; other site 568703003580 GTP/Mg2+ binding site [chemical binding]; other site 568703003581 Switch I region; other site 568703003582 G2 box; other site 568703003583 G3 box; other site 568703003584 Switch II region; other site 568703003585 G4 box; other site 568703003586 G5 box; other site 568703003587 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 568703003588 putative metal binding site [ion binding]; other site 568703003589 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703003590 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703003591 substrate binding pocket [chemical binding]; other site 568703003592 membrane-bound complex binding site; other site 568703003593 hinge residues; other site 568703003594 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703003595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703003596 dimer interface [polypeptide binding]; other site 568703003597 conserved gate region; other site 568703003598 putative PBP binding loops; other site 568703003599 ABC-ATPase subunit interface; other site 568703003600 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568703003601 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568703003602 Walker A/P-loop; other site 568703003603 ATP binding site [chemical binding]; other site 568703003604 Q-loop/lid; other site 568703003605 ABC transporter signature motif; other site 568703003606 Walker B; other site 568703003607 D-loop; other site 568703003608 H-loop/switch region; other site 568703003609 Pleckstrin homology-like domain; Region: PH-like; cl17171 568703003610 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 568703003611 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 568703003612 GIY-YIG motif/motif A; other site 568703003613 active site 568703003614 catalytic site [active] 568703003615 putative DNA binding site [nucleotide binding]; other site 568703003616 metal binding site [ion binding]; metal-binding site 568703003617 UvrB/uvrC motif; Region: UVR; pfam02151 568703003618 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 568703003619 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 568703003620 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703003621 active site 568703003622 phosphorylation site [posttranslational modification] 568703003623 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 568703003624 active site 568703003625 P-loop; other site 568703003626 phosphorylation site [posttranslational modification] 568703003627 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 568703003628 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 568703003629 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 568703003630 putative substrate binding site [chemical binding]; other site 568703003631 putative ATP binding site [chemical binding]; other site 568703003632 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703003633 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 568703003634 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568703003635 GTPase CgtA; Reviewed; Region: obgE; PRK12297 568703003636 GTP1/OBG; Region: GTP1_OBG; pfam01018 568703003637 Obg GTPase; Region: Obg; cd01898 568703003638 G1 box; other site 568703003639 GTP/Mg2+ binding site [chemical binding]; other site 568703003640 Switch I region; other site 568703003641 G2 box; other site 568703003642 G3 box; other site 568703003643 Switch II region; other site 568703003644 G4 box; other site 568703003645 G5 box; other site 568703003646 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 568703003647 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 568703003648 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 568703003649 catalytic triad [active] 568703003650 catalytic triad [active] 568703003651 oxyanion hole [active] 568703003652 ribonuclease Z; Region: RNase_Z; TIGR02651 568703003653 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 568703003654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703003655 NAD(P) binding site [chemical binding]; other site 568703003656 active site 568703003657 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 568703003658 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 568703003659 Clp amino terminal domain; Region: Clp_N; pfam02861 568703003660 Clp amino terminal domain; Region: Clp_N; pfam02861 568703003661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703003662 Walker A motif; other site 568703003663 ATP binding site [chemical binding]; other site 568703003664 Walker B motif; other site 568703003665 arginine finger; other site 568703003666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703003667 Walker A motif; other site 568703003668 ATP binding site [chemical binding]; other site 568703003669 Walker B motif; other site 568703003670 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 568703003671 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 568703003672 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 568703003673 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 568703003674 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 568703003675 active site 568703003676 metal binding site [ion binding]; metal-binding site 568703003677 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 568703003678 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 568703003679 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 568703003680 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 568703003681 active site 568703003682 PHP Thumb interface [polypeptide binding]; other site 568703003683 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 568703003684 generic binding surface I; other site 568703003685 generic binding surface II; other site 568703003686 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 568703003687 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 568703003688 active site 568703003689 ADP/pyrophosphate binding site [chemical binding]; other site 568703003690 dimerization interface [polypeptide binding]; other site 568703003691 allosteric effector site; other site 568703003692 fructose-1,6-bisphosphate binding site; other site 568703003693 pyruvate kinase; Provisional; Region: PRK06354 568703003694 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 568703003695 domain interfaces; other site 568703003696 active site 568703003697 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 568703003698 Protein of unknown function (DUF441); Region: DUF441; pfam04284 568703003699 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 568703003700 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 568703003701 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 568703003702 active site 568703003703 Int/Topo IB signature motif; other site 568703003704 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 568703003705 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 568703003706 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 568703003707 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703003708 RNA binding surface [nucleotide binding]; other site 568703003709 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 568703003710 active site 568703003711 Predicted membrane protein [Function unknown]; Region: COG3601 568703003712 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 568703003713 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 568703003714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 568703003715 DEAD-like helicases superfamily; Region: DEXDc; smart00487 568703003716 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703003717 ATP binding site [chemical binding]; other site 568703003718 putative Mg++ binding site [ion binding]; other site 568703003719 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703003720 nucleotide binding region [chemical binding]; other site 568703003721 ATP-binding site [chemical binding]; other site 568703003722 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568703003723 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 568703003724 cytidylate kinase; Provisional; Region: cmk; PRK00023 568703003725 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 568703003726 CMP-binding site; other site 568703003727 The sites determining sugar specificity; other site 568703003728 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 568703003729 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 568703003730 RNA binding site [nucleotide binding]; other site 568703003731 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 568703003732 RNA binding site [nucleotide binding]; other site 568703003733 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 568703003734 RNA binding site [nucleotide binding]; other site 568703003735 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 568703003736 RNA binding site [nucleotide binding]; other site 568703003737 GTP-binding protein Der; Reviewed; Region: PRK00093 568703003738 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 568703003739 G1 box; other site 568703003740 GTP/Mg2+ binding site [chemical binding]; other site 568703003741 Switch I region; other site 568703003742 G2 box; other site 568703003743 Switch II region; other site 568703003744 G3 box; other site 568703003745 G4 box; other site 568703003746 G5 box; other site 568703003747 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 568703003748 G1 box; other site 568703003749 GTP/Mg2+ binding site [chemical binding]; other site 568703003750 Switch I region; other site 568703003751 G2 box; other site 568703003752 G3 box; other site 568703003753 Switch II region; other site 568703003754 G4 box; other site 568703003755 G5 box; other site 568703003756 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 568703003757 IHF dimer interface [polypeptide binding]; other site 568703003758 IHF - DNA interface [nucleotide binding]; other site 568703003759 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 568703003760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568703003761 TPR motif; other site 568703003762 binding surface 568703003763 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568703003764 binding surface 568703003765 TPR motif; other site 568703003766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568703003767 binding surface 568703003768 TPR motif; other site 568703003769 Uncharacterized conserved protein [Function unknown]; Region: COG1284 568703003770 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 568703003771 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 568703003772 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 568703003773 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 568703003774 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 568703003775 active site 568703003776 NTP binding site [chemical binding]; other site 568703003777 metal binding triad [ion binding]; metal-binding site 568703003778 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 568703003779 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 568703003780 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 568703003781 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703003782 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703003783 ABC transporter; Region: ABC_tran_2; pfam12848 568703003784 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703003785 thymidylate synthase; Region: thym_sym; TIGR03284 568703003786 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 568703003787 dimerization interface [polypeptide binding]; other site 568703003788 active site 568703003789 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 568703003790 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 568703003791 folate binding site [chemical binding]; other site 568703003792 NADP+ binding site [chemical binding]; other site 568703003793 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 568703003794 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 568703003795 EDD domain protein, DegV family; Region: DegV; TIGR00762 568703003796 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 568703003797 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 568703003798 active site 568703003799 catalytic triad [active] 568703003800 oxyanion hole [active] 568703003801 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 568703003802 methionine sulfoxide reductase A; Provisional; Region: PRK14054 568703003803 hypothetical protein; Provisional; Region: PRK13672 568703003804 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 568703003805 C-terminal peptidase (prc); Region: prc; TIGR00225 568703003806 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 568703003807 protein binding site [polypeptide binding]; other site 568703003808 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 568703003809 Catalytic dyad [active] 568703003810 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 568703003811 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 568703003812 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 568703003813 GTP/Mg2+ binding site [chemical binding]; other site 568703003814 G4 box; other site 568703003815 G5 box; other site 568703003816 G1 box; other site 568703003817 Switch I region; other site 568703003818 G2 box; other site 568703003819 G3 box; other site 568703003820 Switch II region; other site 568703003821 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 568703003822 RNA/DNA hybrid binding site [nucleotide binding]; other site 568703003823 active site 568703003824 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 568703003825 DNA protecting protein DprA; Region: dprA; TIGR00732 568703003826 DNA topoisomerase I; Validated; Region: PRK05582 568703003827 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 568703003828 active site 568703003829 interdomain interaction site; other site 568703003830 putative metal-binding site [ion binding]; other site 568703003831 nucleotide binding site [chemical binding]; other site 568703003832 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 568703003833 domain I; other site 568703003834 DNA binding groove [nucleotide binding] 568703003835 phosphate binding site [ion binding]; other site 568703003836 domain II; other site 568703003837 domain III; other site 568703003838 nucleotide binding site [chemical binding]; other site 568703003839 catalytic site [active] 568703003840 domain IV; other site 568703003841 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 568703003842 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 568703003843 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 568703003844 Glucose inhibited division protein A; Region: GIDA; pfam01134 568703003845 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 568703003846 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 568703003847 active site 568703003848 Int/Topo IB signature motif; other site 568703003849 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 568703003850 active site 568703003851 HslU subunit interaction site [polypeptide binding]; other site 568703003852 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 568703003853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703003854 Walker A motif; other site 568703003855 ATP binding site [chemical binding]; other site 568703003856 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 568703003857 Walker B motif; other site 568703003858 arginine finger; other site 568703003859 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 568703003860 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 568703003861 active site 568703003862 catalytic residues [active] 568703003863 membrane protein; Provisional; Region: PRK14392 568703003864 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 568703003865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703003866 Mg2+ binding site [ion binding]; other site 568703003867 G-X-G motif; other site 568703003868 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 568703003869 anchoring element; other site 568703003870 dimer interface [polypeptide binding]; other site 568703003871 ATP binding site [chemical binding]; other site 568703003872 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 568703003873 active site 568703003874 putative metal-binding site [ion binding]; other site 568703003875 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 568703003876 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 568703003877 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 568703003878 CAP-like domain; other site 568703003879 active site 568703003880 primary dimer interface [polypeptide binding]; other site 568703003881 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703003882 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 568703003883 Pyruvate formate lyase 1; Region: PFL1; cd01678 568703003884 coenzyme A binding site [chemical binding]; other site 568703003885 active site 568703003886 catalytic residues [active] 568703003887 glycine loop; other site 568703003888 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 568703003889 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568703003890 FeS/SAM binding site; other site 568703003891 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703003892 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703003893 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703003894 dimerization interface [polypeptide binding]; other site 568703003895 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 568703003896 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 568703003897 DHHA2 domain; Region: DHHA2; pfam02833 568703003898 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 568703003899 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 568703003900 active site 568703003901 catalytic residues [active] 568703003902 DNA binding site [nucleotide binding] 568703003903 Int/Topo IB signature motif; other site 568703003904 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703003905 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568703003906 Walker A/P-loop; other site 568703003907 ATP binding site [chemical binding]; other site 568703003908 Q-loop/lid; other site 568703003909 ABC transporter signature motif; other site 568703003910 Walker B; other site 568703003911 D-loop; other site 568703003912 H-loop/switch region; other site 568703003913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703003914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703003915 ATP binding site [chemical binding]; other site 568703003916 Mg2+ binding site [ion binding]; other site 568703003917 G-X-G motif; other site 568703003918 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703003919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703003920 active site 568703003921 phosphorylation site [posttranslational modification] 568703003922 intermolecular recognition site; other site 568703003923 dimerization interface [polypeptide binding]; other site 568703003924 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703003925 DNA binding site [nucleotide binding] 568703003926 H+ Antiporter protein; Region: 2A0121; TIGR00900 568703003927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703003928 putative substrate translocation pore; other site 568703003929 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703003930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 568703003931 Coenzyme A binding pocket [chemical binding]; other site 568703003932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703003933 Coenzyme A binding pocket [chemical binding]; other site 568703003934 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 568703003935 dimer interface [polypeptide binding]; other site 568703003936 FMN binding site [chemical binding]; other site 568703003937 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 568703003938 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 568703003939 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 568703003940 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703003941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703003942 homodimer interface [polypeptide binding]; other site 568703003943 catalytic residue [active] 568703003944 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 568703003945 metal binding site [ion binding]; metal-binding site 568703003946 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 568703003947 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 568703003948 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 568703003949 substrate binding site [chemical binding]; other site 568703003950 glutamase interaction surface [polypeptide binding]; other site 568703003951 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 568703003952 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 568703003953 catalytic residues [active] 568703003954 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 568703003955 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 568703003956 putative active site [active] 568703003957 oxyanion strand; other site 568703003958 catalytic triad [active] 568703003959 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 568703003960 4-fold oligomerization interface [polypeptide binding]; other site 568703003961 putative active site pocket [active] 568703003962 metal binding residues [ion binding]; metal-binding site 568703003963 3-fold/trimer interface [polypeptide binding]; other site 568703003964 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 568703003965 histidinol dehydrogenase; Region: hisD; TIGR00069 568703003966 NAD binding site [chemical binding]; other site 568703003967 dimerization interface [polypeptide binding]; other site 568703003968 product binding site; other site 568703003969 substrate binding site [chemical binding]; other site 568703003970 zinc binding site [ion binding]; other site 568703003971 catalytic residues [active] 568703003972 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 568703003973 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 568703003974 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 568703003975 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 568703003976 dimer interface [polypeptide binding]; other site 568703003977 motif 1; other site 568703003978 active site 568703003979 motif 2; other site 568703003980 motif 3; other site 568703003981 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 568703003982 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703003983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703003984 homodimer interface [polypeptide binding]; other site 568703003985 catalytic residue [active] 568703003986 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 568703003987 dimer interface [polypeptide binding]; other site 568703003988 ADP-ribose binding site [chemical binding]; other site 568703003989 active site 568703003990 nudix motif; other site 568703003991 metal binding site [ion binding]; metal-binding site 568703003992 EDD domain protein, DegV family; Region: DegV; TIGR00762 568703003993 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 568703003994 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 568703003995 Domain of unknown function (DUF814); Region: DUF814; pfam05670 568703003996 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535 568703003997 metal binding site [ion binding]; metal-binding site 568703003998 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 568703003999 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 568703004000 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703004001 active site 568703004002 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 568703004003 active site 568703004004 dimer interface [polypeptide binding]; other site 568703004005 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 568703004006 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 568703004007 heterodimer interface [polypeptide binding]; other site 568703004008 active site 568703004009 FMN binding site [chemical binding]; other site 568703004010 homodimer interface [polypeptide binding]; other site 568703004011 substrate binding site [chemical binding]; other site 568703004012 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 568703004013 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568703004014 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 568703004015 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 568703004016 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568703004017 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568703004018 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 568703004019 IMP binding site; other site 568703004020 dimer interface [polypeptide binding]; other site 568703004021 interdomain contacts; other site 568703004022 partial ornithine binding site; other site 568703004023 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 568703004024 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 568703004025 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 568703004026 catalytic site [active] 568703004027 subunit interface [polypeptide binding]; other site 568703004028 dihydroorotase; Validated; Region: pyrC; PRK09357 568703004029 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568703004030 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 568703004031 active site 568703004032 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 568703004033 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 568703004034 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 568703004035 uracil transporter; Provisional; Region: PRK10720 568703004036 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 568703004037 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703004038 active site 568703004039 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 568703004040 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703004041 RNA binding surface [nucleotide binding]; other site 568703004042 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 568703004043 active site 568703004044 lipoprotein signal peptidase; Provisional; Region: PRK14797 568703004045 lipoprotein signal peptidase; Provisional; Region: PRK14787 568703004046 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 568703004047 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 568703004048 Potassium binding sites [ion binding]; other site 568703004049 Cesium cation binding sites [ion binding]; other site 568703004050 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 568703004051 RNA/DNA hybrid binding site [nucleotide binding]; other site 568703004052 active site 568703004053 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 568703004054 dimer interface [polypeptide binding]; other site 568703004055 FMN binding site [chemical binding]; other site 568703004056 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 568703004057 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 568703004058 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 568703004059 putative active site [active] 568703004060 catalytic site [active] 568703004061 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 568703004062 putative active site [active] 568703004063 catalytic site [active] 568703004064 Mga helix-turn-helix domain; Region: Mga; pfam05043 568703004065 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 568703004066 catalytic residues [active] 568703004067 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 568703004068 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 568703004069 Class I ribonucleotide reductase; Region: RNR_I; cd01679 568703004070 active site 568703004071 dimer interface [polypeptide binding]; other site 568703004072 catalytic residues [active] 568703004073 effector binding site; other site 568703004074 R2 peptide binding site; other site 568703004075 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 568703004076 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 568703004077 dimer interface [polypeptide binding]; other site 568703004078 putative radical transfer pathway; other site 568703004079 diiron center [ion binding]; other site 568703004080 tyrosyl radical; other site 568703004081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703004082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703004083 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703004084 dimerization interface [polypeptide binding]; other site 568703004085 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 568703004086 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 568703004087 active site 568703004088 Zn binding site [ion binding]; other site 568703004089 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 568703004090 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 568703004091 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 568703004092 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 568703004093 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 568703004094 putative ligand binding site [chemical binding]; other site 568703004095 NAD binding site [chemical binding]; other site 568703004096 catalytic site [active] 568703004097 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 568703004098 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 568703004099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 568703004100 cell division protein GpsB; Provisional; Region: PRK14127 568703004101 DivIVA domain; Region: DivI1A_domain; TIGR03544 568703004102 hypothetical protein; Provisional; Region: PRK13660 568703004103 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 568703004104 Transglycosylase; Region: Transgly; pfam00912 568703004105 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 568703004106 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568703004107 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 568703004108 catalytic motif [active] 568703004109 Zn binding site [ion binding]; other site 568703004110 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 568703004111 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568703004112 minor groove reading motif; other site 568703004113 helix-hairpin-helix signature motif; other site 568703004114 substrate binding pocket [chemical binding]; other site 568703004115 active site 568703004116 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 568703004117 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 568703004118 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 568703004119 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 568703004120 putative dimer interface [polypeptide binding]; other site 568703004121 putative anticodon binding site; other site 568703004122 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 568703004123 homodimer interface [polypeptide binding]; other site 568703004124 motif 1; other site 568703004125 motif 2; other site 568703004126 active site 568703004127 motif 3; other site 568703004128 aspartate aminotransferase; Provisional; Region: PRK05764 568703004129 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703004130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703004131 homodimer interface [polypeptide binding]; other site 568703004132 catalytic residue [active] 568703004133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 568703004134 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 568703004135 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 568703004136 active site 568703004137 catalytic site [active] 568703004138 substrate binding site [chemical binding]; other site 568703004139 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 568703004140 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 568703004141 DEAD/DEAH box helicase; Region: DEAD; pfam00270 568703004142 ATP binding site [chemical binding]; other site 568703004143 Family description; Region: UvrD_C_2; pfam13538 568703004144 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 568703004145 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 568703004146 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 568703004147 mevalonate kinase; Region: mevalon_kin; TIGR00549 568703004148 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 568703004149 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 568703004150 diphosphomevalonate decarboxylase; Region: PLN02407 568703004151 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 568703004152 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 568703004153 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 568703004154 homotetramer interface [polypeptide binding]; other site 568703004155 FMN binding site [chemical binding]; other site 568703004156 homodimer contacts [polypeptide binding]; other site 568703004157 putative active site [active] 568703004158 putative substrate binding site [chemical binding]; other site 568703004159 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 568703004160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703004161 S-adenosylmethionine binding site [chemical binding]; other site 568703004162 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 568703004163 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 568703004164 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 568703004165 active site 1 [active] 568703004166 dimer interface [polypeptide binding]; other site 568703004167 hexamer interface [polypeptide binding]; other site 568703004168 active site 2 [active] 568703004169 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703004170 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703004171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703004172 Walker A/P-loop; other site 568703004173 ATP binding site [chemical binding]; other site 568703004174 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703004175 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703004176 Walker A/P-loop; other site 568703004177 ATP binding site [chemical binding]; other site 568703004178 Q-loop/lid; other site 568703004179 ABC transporter signature motif; other site 568703004180 Walker B; other site 568703004181 D-loop; other site 568703004182 H-loop/switch region; other site 568703004183 Uncharacterized conserved protein [Function unknown]; Region: COG0327 568703004184 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 568703004185 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 568703004186 Family of unknown function (DUF633); Region: DUF633; pfam04816 568703004187 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 568703004188 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 568703004189 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568703004190 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 568703004191 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568703004192 DNA binding residues [nucleotide binding] 568703004193 DNA primase; Validated; Region: dnaG; PRK05667 568703004194 CHC2 zinc finger; Region: zf-CHC2; pfam01807 568703004195 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 568703004196 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 568703004197 active site 568703004198 metal binding site [ion binding]; metal-binding site 568703004199 interdomain interaction site; other site 568703004200 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 568703004201 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 568703004202 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 568703004203 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 568703004204 dimer interface [polypeptide binding]; other site 568703004205 motif 1; other site 568703004206 active site 568703004207 motif 2; other site 568703004208 motif 3; other site 568703004209 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 568703004210 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 568703004211 Int/Topo IB signature motif; other site 568703004212 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 568703004213 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 568703004214 active site 568703004215 Bacterial SH3 domain; Region: SH3_5; pfam08460 568703004216 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 568703004217 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568703004218 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 568703004219 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 568703004220 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 568703004221 Phage tail protein; Region: Sipho_tail; pfam05709 568703004222 Phage tail protein; Region: Sipho_tail; cl17486 568703004223 Phage-related tail protein [Function unknown]; Region: COG5283 568703004224 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 568703004225 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 568703004226 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568703004227 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568703004228 catalytic residue [active] 568703004229 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 568703004230 Phage major tail protein; Region: Phage_tail; pfam04630 568703004231 Protein of unknown function (DUF806); Region: DUF806; pfam05657 568703004232 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 568703004233 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 568703004234 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 568703004235 Phage capsid family; Region: Phage_capsid; pfam05065 568703004236 Phage portal protein; Region: Phage_portal; pfam04860 568703004237 Phage-related protein [Function unknown]; Region: COG4695; cl01923 568703004238 Phage Terminase; Region: Terminase_1; pfam03354 568703004239 Phage terminase, small subunit; Region: Terminase_4; pfam05119 568703004240 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 568703004241 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 568703004242 DXD motif; other site 568703004243 Transposase domain (DUF772); Region: DUF772; pfam05598 568703004244 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703004245 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568703004246 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 568703004247 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 568703004248 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 568703004249 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703004250 Walker A/P-loop; other site 568703004251 ATP binding site [chemical binding]; other site 568703004252 Q-loop/lid; other site 568703004253 ABC transporter signature motif; other site 568703004254 Walker B; other site 568703004255 D-loop; other site 568703004256 H-loop/switch region; other site 568703004257 Recombination protein O N terminal; Region: RecO_N; pfam11967 568703004258 DNA repair protein RecO; Region: reco; TIGR00613 568703004259 Recombination protein O C terminal; Region: RecO_C; pfam02565 568703004260 GTPase Era; Reviewed; Region: era; PRK00089 568703004261 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 568703004262 G1 box; other site 568703004263 GTP/Mg2+ binding site [chemical binding]; other site 568703004264 Switch I region; other site 568703004265 G2 box; other site 568703004266 Switch II region; other site 568703004267 G3 box; other site 568703004268 G4 box; other site 568703004269 G5 box; other site 568703004270 KH domain; Region: KH_2; pfam07650 568703004271 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 568703004272 active site 568703004273 catalytic motif [active] 568703004274 Zn binding site [ion binding]; other site 568703004275 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 568703004276 metal-binding heat shock protein; Provisional; Region: PRK00016 568703004277 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 568703004278 PhoH-like protein; Region: PhoH; pfam02562 568703004279 Yqey-like protein; Region: YqeY; pfam09424 568703004280 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 568703004281 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 568703004282 endonuclease IV; Provisional; Region: PRK01060 568703004283 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 568703004284 AP (apurinic/apyrimidinic) site pocket; other site 568703004285 DNA interaction; other site 568703004286 Metal-binding active site; metal-binding site 568703004287 Uncharacterized conserved protein [Function unknown]; Region: COG1284 568703004288 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 568703004289 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 568703004290 methionine sulfoxide reductase B; Provisional; Region: PRK00222 568703004291 SelR domain; Region: SelR; pfam01641 568703004292 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 568703004293 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 568703004294 dimer interface [polypeptide binding]; other site 568703004295 anticodon binding site; other site 568703004296 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 568703004297 homodimer interface [polypeptide binding]; other site 568703004298 motif 1; other site 568703004299 active site 568703004300 motif 2; other site 568703004301 GAD domain; Region: GAD; pfam02938 568703004302 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 568703004303 motif 3; other site 568703004304 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 568703004305 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 568703004306 dimer interface [polypeptide binding]; other site 568703004307 motif 1; other site 568703004308 active site 568703004309 motif 2; other site 568703004310 motif 3; other site 568703004311 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 568703004312 anticodon binding site; other site 568703004313 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703004314 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 568703004315 Walker A/P-loop; other site 568703004316 ATP binding site [chemical binding]; other site 568703004317 Q-loop/lid; other site 568703004318 ABC transporter signature motif; other site 568703004319 Walker B; other site 568703004320 D-loop; other site 568703004321 H-loop/switch region; other site 568703004322 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 568703004323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 568703004324 Bacterial SH3 domain; Region: SH3_3; pfam08239 568703004325 Bacterial SH3 domain; Region: SH3_3; pfam08239 568703004326 Bacterial SH3 domain; Region: SH3_3; pfam08239 568703004327 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 568703004328 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 568703004329 active site 568703004330 metal binding site [ion binding]; metal-binding site 568703004331 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 568703004332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703004333 motif II; other site 568703004334 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 568703004335 putative active site [active] 568703004336 dimerization interface [polypeptide binding]; other site 568703004337 putative tRNAtyr binding site [nucleotide binding]; other site 568703004338 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 568703004339 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568703004340 Zn2+ binding site [ion binding]; other site 568703004341 Mg2+ binding site [ion binding]; other site 568703004342 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 568703004343 synthetase active site [active] 568703004344 NTP binding site [chemical binding]; other site 568703004345 metal binding site [ion binding]; metal-binding site 568703004346 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 568703004347 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 568703004348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 568703004349 RNA methyltransferase, RsmE family; Region: TIGR00046 568703004350 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 568703004351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703004352 S-adenosylmethionine binding site [chemical binding]; other site 568703004353 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 568703004354 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 568703004355 active site 568703004356 DNA binding site [nucleotide binding] 568703004357 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 568703004358 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 568703004359 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 568703004360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703004361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703004362 WHG domain; Region: WHG; pfam13305 568703004363 Transposase domain (DUF772); Region: DUF772; pfam05598 568703004364 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703004365 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568703004366 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568703004367 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568703004368 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703004369 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703004370 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 568703004371 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 568703004372 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 568703004373 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 568703004374 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703004375 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 568703004376 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 568703004377 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 568703004378 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 568703004379 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 568703004380 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 568703004381 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 568703004382 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 568703004383 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 568703004384 surface protein repeat Ser-Ala-175; Region: SerAla_Lrha_rpt; TIGR04319 568703004385 surface protein repeat Ser-Ala-175; Region: SerAla_Lrha_rpt; TIGR04319 568703004386 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 568703004387 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 568703004388 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 568703004389 putative deacylase active site [active] 568703004390 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703004391 active site 568703004392 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 568703004393 DHH family; Region: DHH; pfam01368 568703004394 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 568703004395 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 568703004396 GTP-binding protein LepA; Provisional; Region: PRK05433 568703004397 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 568703004398 G1 box; other site 568703004399 putative GEF interaction site [polypeptide binding]; other site 568703004400 GTP/Mg2+ binding site [chemical binding]; other site 568703004401 Switch I region; other site 568703004402 G2 box; other site 568703004403 G3 box; other site 568703004404 Switch II region; other site 568703004405 G4 box; other site 568703004406 G5 box; other site 568703004407 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 568703004408 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 568703004409 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 568703004410 chaperone protein DnaJ; Provisional; Region: PRK14276 568703004411 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 568703004412 HSP70 interaction site [polypeptide binding]; other site 568703004413 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 568703004414 substrate binding site [polypeptide binding]; other site 568703004415 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 568703004416 Zn binding sites [ion binding]; other site 568703004417 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 568703004418 dimer interface [polypeptide binding]; other site 568703004419 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 568703004420 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 568703004421 nucleotide binding site [chemical binding]; other site 568703004422 NEF interaction site [polypeptide binding]; other site 568703004423 SBD interface [polypeptide binding]; other site 568703004424 GrpE; Region: GrpE; pfam01025 568703004425 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 568703004426 dimer interface [polypeptide binding]; other site 568703004427 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 568703004428 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 568703004429 HTH domain; Region: HTH_11; pfam08279 568703004430 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 568703004431 HemN C-terminal domain; Region: HemN_C; pfam06969 568703004432 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 568703004433 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 568703004434 active site 568703004435 Riboflavin kinase; Region: Flavokinase; smart00904 568703004436 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 568703004437 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 568703004438 RNA binding site [nucleotide binding]; other site 568703004439 active site 568703004440 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 568703004441 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 568703004442 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 568703004443 translation initiation factor IF-2; Region: IF-2; TIGR00487 568703004444 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 568703004445 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 568703004446 G1 box; other site 568703004447 putative GEF interaction site [polypeptide binding]; other site 568703004448 GTP/Mg2+ binding site [chemical binding]; other site 568703004449 Switch I region; other site 568703004450 G2 box; other site 568703004451 G3 box; other site 568703004452 Switch II region; other site 568703004453 G4 box; other site 568703004454 G5 box; other site 568703004455 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 568703004456 Translation-initiation factor 2; Region: IF-2; pfam11987 568703004457 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 568703004458 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 568703004459 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 568703004460 putative RNA binding cleft [nucleotide binding]; other site 568703004461 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 568703004462 NusA N-terminal domain; Region: NusA_N; pfam08529 568703004463 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 568703004464 RNA binding site [nucleotide binding]; other site 568703004465 homodimer interface [polypeptide binding]; other site 568703004466 NusA-like KH domain; Region: KH_5; pfam13184 568703004467 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 568703004468 G-X-X-G motif; other site 568703004469 ribosome maturation protein RimP; Reviewed; Region: PRK00092 568703004470 Sm and related proteins; Region: Sm_like; cl00259 568703004471 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 568703004472 putative oligomer interface [polypeptide binding]; other site 568703004473 putative RNA binding site [nucleotide binding]; other site 568703004474 DNA polymerase III PolC; Validated; Region: polC; PRK00448 568703004475 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 568703004476 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 568703004477 generic binding surface II; other site 568703004478 generic binding surface I; other site 568703004479 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 568703004480 active site 568703004481 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 568703004482 active site 568703004483 catalytic site [active] 568703004484 substrate binding site [chemical binding]; other site 568703004485 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 568703004486 prolyl-tRNA synthetase; Provisional; Region: PRK09194 568703004487 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 568703004488 dimer interface [polypeptide binding]; other site 568703004489 motif 1; other site 568703004490 active site 568703004491 motif 2; other site 568703004492 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 568703004493 putative deacylase active site [active] 568703004494 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 568703004495 active site 568703004496 motif 3; other site 568703004497 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 568703004498 anticodon binding site; other site 568703004499 RIP metalloprotease RseP; Region: TIGR00054 568703004500 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 568703004501 active site 568703004502 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 568703004503 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 568703004504 protein binding site [polypeptide binding]; other site 568703004505 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 568703004506 putative substrate binding region [chemical binding]; other site 568703004507 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 568703004508 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 568703004509 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 568703004510 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 568703004511 catalytic residue [active] 568703004512 putative FPP diphosphate binding site; other site 568703004513 putative FPP binding hydrophobic cleft; other site 568703004514 dimer interface [polypeptide binding]; other site 568703004515 putative IPP diphosphate binding site; other site 568703004516 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568703004517 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703004518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 568703004519 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703004520 putative transposase OrfB; Reviewed; Region: PHA02517 568703004521 HTH-like domain; Region: HTH_21; pfam13276 568703004522 Integrase core domain; Region: rve; pfam00665 568703004523 Integrase core domain; Region: rve_2; pfam13333 568703004524 ribosome recycling factor; Reviewed; Region: frr; PRK00083 568703004525 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 568703004526 hinge region; other site 568703004527 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 568703004528 putative nucleotide binding site [chemical binding]; other site 568703004529 uridine monophosphate binding site [chemical binding]; other site 568703004530 homohexameric interface [polypeptide binding]; other site 568703004531 elongation factor Ts; Provisional; Region: tsf; PRK09377 568703004532 UBA/TS-N domain; Region: UBA; pfam00627 568703004533 Elongation factor TS; Region: EF_TS; pfam00889 568703004534 Elongation factor TS; Region: EF_TS; pfam00889 568703004535 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 568703004536 rRNA interaction site [nucleotide binding]; other site 568703004537 S8 interaction site; other site 568703004538 putative laminin-1 binding site; other site 568703004539 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 568703004540 GIY-YIG motif/motif A; other site 568703004541 putative active site [active] 568703004542 putative metal binding site [ion binding]; other site 568703004543 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 568703004544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703004545 S-adenosylmethionine binding site [chemical binding]; other site 568703004546 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 568703004547 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 568703004548 putative acyl-acceptor binding pocket; other site 568703004549 amino acid transporter; Region: 2A0306; TIGR00909 568703004550 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 568703004551 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 568703004552 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703004553 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703004554 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 568703004555 Walker A/P-loop; other site 568703004556 ATP binding site [chemical binding]; other site 568703004557 Q-loop/lid; other site 568703004558 ABC transporter signature motif; other site 568703004559 Walker B; other site 568703004560 D-loop; other site 568703004561 H-loop/switch region; other site 568703004562 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703004563 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 568703004564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703004565 Walker A/P-loop; other site 568703004566 ATP binding site [chemical binding]; other site 568703004567 Q-loop/lid; other site 568703004568 ABC transporter signature motif; other site 568703004569 Walker B; other site 568703004570 D-loop; other site 568703004571 H-loop/switch region; other site 568703004572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 568703004573 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 568703004574 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 568703004575 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 568703004576 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 568703004577 RimM N-terminal domain; Region: RimM; pfam01782 568703004578 PRC-barrel domain; Region: PRC; pfam05239 568703004579 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 568703004580 KH domain; Region: KH_4; pfam13083 568703004581 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 568703004582 signal recognition particle protein; Provisional; Region: PRK10867 568703004583 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 568703004584 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 568703004585 P loop; other site 568703004586 GTP binding site [chemical binding]; other site 568703004587 Signal peptide binding domain; Region: SRP_SPB; pfam02978 568703004588 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 568703004589 putative DNA-binding protein; Validated; Region: PRK00118 568703004590 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 568703004591 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 568703004592 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 568703004593 P loop; other site 568703004594 GTP binding site [chemical binding]; other site 568703004595 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 568703004596 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 568703004597 Walker A/P-loop; other site 568703004598 ATP binding site [chemical binding]; other site 568703004599 Q-loop/lid; other site 568703004600 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 568703004601 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 568703004602 ABC transporter signature motif; other site 568703004603 Walker B; other site 568703004604 D-loop; other site 568703004605 H-loop/switch region; other site 568703004606 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 568703004607 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 568703004608 dimerization interface [polypeptide binding]; other site 568703004609 active site 568703004610 metal binding site [ion binding]; metal-binding site 568703004611 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 568703004612 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 568703004613 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 568703004614 peptide binding site [polypeptide binding]; other site 568703004615 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 568703004616 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 568703004617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703004618 dimer interface [polypeptide binding]; other site 568703004619 conserved gate region; other site 568703004620 putative PBP binding loops; other site 568703004621 ABC-ATPase subunit interface; other site 568703004622 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568703004623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703004624 dimer interface [polypeptide binding]; other site 568703004625 conserved gate region; other site 568703004626 putative PBP binding loops; other site 568703004627 ABC-ATPase subunit interface; other site 568703004628 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568703004629 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568703004630 Walker A/P-loop; other site 568703004631 ATP binding site [chemical binding]; other site 568703004632 Q-loop/lid; other site 568703004633 ABC transporter signature motif; other site 568703004634 Walker B; other site 568703004635 D-loop; other site 568703004636 H-loop/switch region; other site 568703004637 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568703004638 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568703004639 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568703004640 Walker A/P-loop; other site 568703004641 ATP binding site [chemical binding]; other site 568703004642 Q-loop/lid; other site 568703004643 ABC transporter signature motif; other site 568703004644 Walker B; other site 568703004645 D-loop; other site 568703004646 H-loop/switch region; other site 568703004647 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568703004648 acyl carrier protein; Provisional; Region: acpP; PRK00982 568703004649 putative phosphate acyltransferase; Provisional; Region: PRK05331 568703004650 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 568703004651 Y-family of DNA polymerases; Region: PolY; cl12025 568703004652 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 568703004653 generic binding surface II; other site 568703004654 ssDNA binding site; other site 568703004655 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703004656 ATP binding site [chemical binding]; other site 568703004657 putative Mg++ binding site [ion binding]; other site 568703004658 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703004659 nucleotide binding region [chemical binding]; other site 568703004660 ATP-binding site [chemical binding]; other site 568703004661 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 568703004662 DAK2 domain; Region: Dak2; pfam02734 568703004663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 568703004664 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 568703004665 Thiamine pyrophosphokinase; Region: TPK; cd07995 568703004666 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 568703004667 active site 568703004668 dimerization interface [polypeptide binding]; other site 568703004669 thiamine binding site [chemical binding]; other site 568703004670 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 568703004671 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 568703004672 substrate binding site [chemical binding]; other site 568703004673 hexamer interface [polypeptide binding]; other site 568703004674 metal binding site [ion binding]; metal-binding site 568703004675 GTPase RsgA; Reviewed; Region: PRK00098 568703004676 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 568703004677 RNA binding site [nucleotide binding]; other site 568703004678 homodimer interface [polypeptide binding]; other site 568703004679 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 568703004680 GTPase/Zn-binding domain interface [polypeptide binding]; other site 568703004681 GTP/Mg2+ binding site [chemical binding]; other site 568703004682 G4 box; other site 568703004683 G5 box; other site 568703004684 G1 box; other site 568703004685 Switch I region; other site 568703004686 G2 box; other site 568703004687 G3 box; other site 568703004688 Switch II region; other site 568703004689 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 568703004690 Catalytic domain of Protein Kinases; Region: PKc; cd00180 568703004691 active site 568703004692 ATP binding site [chemical binding]; other site 568703004693 substrate binding site [chemical binding]; other site 568703004694 activation loop (A-loop); other site 568703004695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 568703004696 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 568703004697 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 568703004698 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 568703004699 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 568703004700 active site 568703004701 16S rRNA methyltransferase B; Provisional; Region: PRK14902 568703004702 NusB family; Region: NusB; pfam01029 568703004703 putative RNA binding site [nucleotide binding]; other site 568703004704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703004705 S-adenosylmethionine binding site [chemical binding]; other site 568703004706 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 568703004707 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 568703004708 putative active site [active] 568703004709 substrate binding site [chemical binding]; other site 568703004710 putative cosubstrate binding site; other site 568703004711 catalytic site [active] 568703004712 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 568703004713 substrate binding site [chemical binding]; other site 568703004714 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 568703004715 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703004716 ATP binding site [chemical binding]; other site 568703004717 putative Mg++ binding site [ion binding]; other site 568703004718 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703004719 nucleotide binding region [chemical binding]; other site 568703004720 ATP-binding site [chemical binding]; other site 568703004721 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 568703004722 Flavoprotein; Region: Flavoprotein; pfam02441 568703004723 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 568703004724 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 568703004725 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 568703004726 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 568703004727 catalytic site [active] 568703004728 G-X2-G-X-G-K; other site 568703004729 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 568703004730 nucleophile elbow; other site 568703004731 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 568703004732 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 568703004733 Walker A/P-loop; other site 568703004734 ATP binding site [chemical binding]; other site 568703004735 Q-loop/lid; other site 568703004736 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 568703004737 ABC transporter signature motif; other site 568703004738 Walker B; other site 568703004739 D-loop; other site 568703004740 H-loop/switch region; other site 568703004741 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 568703004742 arginine repressor; Provisional; Region: PRK04280 568703004743 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 568703004744 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 568703004745 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703004746 RNA binding surface [nucleotide binding]; other site 568703004747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703004748 S-adenosylmethionine binding site [chemical binding]; other site 568703004749 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 568703004750 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 568703004751 substrate binding pocket [chemical binding]; other site 568703004752 chain length determination region; other site 568703004753 substrate-Mg2+ binding site; other site 568703004754 catalytic residues [active] 568703004755 aspartate-rich region 1; other site 568703004756 active site lid residues [active] 568703004757 aspartate-rich region 2; other site 568703004758 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 568703004759 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 568703004760 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 568703004761 generic binding surface II; other site 568703004762 generic binding surface I; other site 568703004763 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14169 568703004764 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 568703004765 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 568703004766 homodimer interface [polypeptide binding]; other site 568703004767 NADP binding site [chemical binding]; other site 568703004768 substrate binding site [chemical binding]; other site 568703004769 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 568703004770 Asp23 family; Region: Asp23; pfam03780 568703004771 elongation factor P; Validated; Region: PRK00529 568703004772 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 568703004773 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 568703004774 RNA binding site [nucleotide binding]; other site 568703004775 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 568703004776 RNA binding site [nucleotide binding]; other site 568703004777 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 568703004778 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 568703004779 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 568703004780 active site 568703004781 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 568703004782 Protein of unknown function (DUF464); Region: DUF464; pfam04327 568703004783 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 568703004784 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703004785 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568703004786 Walker A/P-loop; other site 568703004787 ATP binding site [chemical binding]; other site 568703004788 Q-loop/lid; other site 568703004789 ABC transporter signature motif; other site 568703004790 Walker B; other site 568703004791 D-loop; other site 568703004792 H-loop/switch region; other site 568703004793 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 568703004794 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 568703004795 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 568703004796 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 568703004797 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 568703004798 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 568703004799 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 568703004800 DNA binding residues [nucleotide binding] 568703004801 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 568703004802 putative dimer interface [polypeptide binding]; other site 568703004803 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 568703004804 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568703004805 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703004806 catalytic residue [active] 568703004807 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 568703004808 Aluminium resistance protein; Region: Alum_res; pfam06838 568703004809 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 568703004810 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 568703004811 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 568703004812 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 568703004813 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 568703004814 active site residue [active] 568703004815 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 568703004816 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568703004817 nucleotide binding site [chemical binding]; other site 568703004818 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 568703004819 Rhomboid family; Region: Rhomboid; pfam01694 568703004820 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 568703004821 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 568703004822 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568703004823 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 568703004824 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 568703004825 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 568703004826 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568703004827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703004828 active site 568703004829 phosphorylation site [posttranslational modification] 568703004830 intermolecular recognition site; other site 568703004831 dimerization interface [polypeptide binding]; other site 568703004832 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568703004833 DNA binding residues [nucleotide binding] 568703004834 dimerization interface [polypeptide binding]; other site 568703004835 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703004836 Histidine kinase; Region: HisKA_3; pfam07730 568703004837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703004838 ATP binding site [chemical binding]; other site 568703004839 Mg2+ binding site [ion binding]; other site 568703004840 G-X-G motif; other site 568703004841 Predicted membrane protein [Function unknown]; Region: COG4758 568703004842 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 568703004843 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 568703004844 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 568703004845 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 568703004846 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 568703004847 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 568703004848 ATP-binding site [chemical binding]; other site 568703004849 Sugar specificity; other site 568703004850 Pyrimidine base specificity; other site 568703004851 YceG-like family; Region: YceG; pfam02618 568703004852 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 568703004853 dimerization interface [polypeptide binding]; other site 568703004854 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 568703004855 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 568703004856 putative tRNA-binding site [nucleotide binding]; other site 568703004857 B3/4 domain; Region: B3_4; pfam03483 568703004858 tRNA synthetase B5 domain; Region: B5; smart00874 568703004859 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 568703004860 dimer interface [polypeptide binding]; other site 568703004861 motif 1; other site 568703004862 motif 3; other site 568703004863 motif 2; other site 568703004864 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 568703004865 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 568703004866 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 568703004867 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 568703004868 dimer interface [polypeptide binding]; other site 568703004869 motif 1; other site 568703004870 active site 568703004871 motif 2; other site 568703004872 motif 3; other site 568703004873 Predicted transcriptional regulators [Transcription]; Region: COG1733 568703004874 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 568703004875 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568703004876 Zn2+ binding site [ion binding]; other site 568703004877 Mg2+ binding site [ion binding]; other site 568703004878 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 568703004879 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 568703004880 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 568703004881 Acylphosphatase; Region: Acylphosphatase; pfam00708 568703004882 OxaA-like protein precursor; Provisional; Region: PRK02463 568703004883 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 568703004884 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703004885 HAMP domain; Region: HAMP; pfam00672 568703004886 dimerization interface [polypeptide binding]; other site 568703004887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703004888 dimer interface [polypeptide binding]; other site 568703004889 phosphorylation site [posttranslational modification] 568703004890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703004891 ATP binding site [chemical binding]; other site 568703004892 Mg2+ binding site [ion binding]; other site 568703004893 G-X-G motif; other site 568703004894 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703004895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703004896 active site 568703004897 phosphorylation site [posttranslational modification] 568703004898 intermolecular recognition site; other site 568703004899 dimerization interface [polypeptide binding]; other site 568703004900 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703004901 DNA binding site [nucleotide binding] 568703004902 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568703004903 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 568703004904 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 568703004905 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 568703004906 Peptidase family M23; Region: Peptidase_M23; pfam01551 568703004907 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 568703004908 Probable transposase; Region: OrfB_IS605; pfam01385 568703004909 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 568703004910 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 568703004911 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 568703004912 hypothetical protein; Provisional; Region: PRK13670 568703004913 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 568703004914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703004915 S-adenosylmethionine binding site [chemical binding]; other site 568703004916 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 568703004917 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568703004918 Zn2+ binding site [ion binding]; other site 568703004919 Mg2+ binding site [ion binding]; other site 568703004920 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 568703004921 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 568703004922 active site 568703004923 (T/H)XGH motif; other site 568703004924 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 568703004925 GTPase YqeH; Provisional; Region: PRK13796 568703004926 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 568703004927 GTP/Mg2+ binding site [chemical binding]; other site 568703004928 G4 box; other site 568703004929 G5 box; other site 568703004930 G1 box; other site 568703004931 Switch I region; other site 568703004932 G2 box; other site 568703004933 G3 box; other site 568703004934 Switch II region; other site 568703004935 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 568703004936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703004937 active site 568703004938 motif I; other site 568703004939 motif II; other site 568703004940 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 568703004941 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568703004942 Zn binding site [ion binding]; other site 568703004943 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 568703004944 Zn binding site [ion binding]; other site 568703004945 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 568703004946 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568703004947 Zn binding site [ion binding]; other site 568703004948 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 568703004949 Zn binding site [ion binding]; other site 568703004950 Predicted esterase [General function prediction only]; Region: COG0400 568703004951 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 568703004952 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 568703004953 putative NAD(P) binding site [chemical binding]; other site 568703004954 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 568703004955 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 568703004956 23S rRNA binding site [nucleotide binding]; other site 568703004957 L21 binding site [polypeptide binding]; other site 568703004958 L13 binding site [polypeptide binding]; other site 568703004959 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 568703004960 translation initiation factor IF-3; Region: infC; TIGR00168 568703004961 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 568703004962 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 568703004963 Predicted transcriptional regulator [Transcription]; Region: COG1959 568703004964 Transcriptional regulator; Region: Rrf2; pfam02082 568703004965 Transcriptional regulator; Region: Rrf2; cl17282 568703004966 Transposase domain (DUF772); Region: DUF772; pfam05598 568703004967 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703004968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703004969 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703004970 putative substrate translocation pore; other site 568703004971 NAD-dependent deacetylase; Provisional; Region: PRK14138 568703004972 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 568703004973 SseB protein; Region: SseB; cl06279 568703004974 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 568703004975 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 568703004976 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 568703004977 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 568703004978 active site 568703004979 dimer interface [polypeptide binding]; other site 568703004980 motif 1; other site 568703004981 motif 2; other site 568703004982 motif 3; other site 568703004983 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 568703004984 anticodon binding site; other site 568703004985 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703004986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703004987 non-specific DNA binding site [nucleotide binding]; other site 568703004988 salt bridge; other site 568703004989 sequence-specific DNA binding site [nucleotide binding]; other site 568703004990 HNH endonuclease; Region: HNH_2; pfam13391 568703004991 primosomal protein DnaI; Reviewed; Region: PRK08939 568703004992 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 568703004993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703004994 Walker A motif; other site 568703004995 ATP binding site [chemical binding]; other site 568703004996 Walker B motif; other site 568703004997 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 568703004998 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 568703004999 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 568703005000 ATP cone domain; Region: ATP-cone; pfam03477 568703005001 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 568703005002 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 568703005003 CoA-binding site [chemical binding]; other site 568703005004 ATP-binding [chemical binding]; other site 568703005005 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 568703005006 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 568703005007 DNA binding site [nucleotide binding] 568703005008 catalytic residue [active] 568703005009 H2TH interface [polypeptide binding]; other site 568703005010 putative catalytic residues [active] 568703005011 turnover-facilitating residue; other site 568703005012 intercalation triad [nucleotide binding]; other site 568703005013 8OG recognition residue [nucleotide binding]; other site 568703005014 putative reading head residues; other site 568703005015 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 568703005016 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 568703005017 DNA polymerase I; Provisional; Region: PRK05755 568703005018 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 568703005019 active site 568703005020 metal binding site 1 [ion binding]; metal-binding site 568703005021 putative 5' ssDNA interaction site; other site 568703005022 metal binding site 3; metal-binding site 568703005023 metal binding site 2 [ion binding]; metal-binding site 568703005024 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 568703005025 putative DNA binding site [nucleotide binding]; other site 568703005026 putative metal binding site [ion binding]; other site 568703005027 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 568703005028 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 568703005029 active site 568703005030 DNA binding site [nucleotide binding] 568703005031 catalytic site [active] 568703005032 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 568703005033 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 568703005034 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 568703005035 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 568703005036 WxL domain surface cell wall-binding; Region: WxL; pfam13731 568703005037 Mga helix-turn-helix domain; Region: Mga; pfam05043 568703005038 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 568703005039 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568703005040 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568703005041 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568703005042 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 568703005043 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 568703005044 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 568703005045 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 568703005046 putative tRNA-binding site [nucleotide binding]; other site 568703005047 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568703005048 catalytic residues [active] 568703005049 Predicted small secreted protein [Function unknown]; Region: COG5584 568703005050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703005051 S-adenosylmethionine binding site [chemical binding]; other site 568703005052 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 568703005053 Phosphotransferase enzyme family; Region: APH; pfam01636 568703005054 active site 568703005055 substrate binding site [chemical binding]; other site 568703005056 ATP binding site [chemical binding]; other site 568703005057 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 568703005058 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568703005059 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703005060 Walker A/P-loop; other site 568703005061 ATP binding site [chemical binding]; other site 568703005062 Q-loop/lid; other site 568703005063 ABC transporter signature motif; other site 568703005064 Walker B; other site 568703005065 D-loop; other site 568703005066 H-loop/switch region; other site 568703005067 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 568703005068 HIT family signature motif; other site 568703005069 catalytic residue [active] 568703005070 YtxH-like protein; Region: YtxH; pfam12732 568703005071 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 568703005072 SurA N-terminal domain; Region: SurA_N_3; cl07813 568703005073 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 568703005074 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 568703005075 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 568703005076 generic binding surface I; other site 568703005077 generic binding surface II; other site 568703005078 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568703005079 Zn2+ binding site [ion binding]; other site 568703005080 Mg2+ binding site [ion binding]; other site 568703005081 Protein of unknown function (DUF964); Region: DUF964; cl01483 568703005082 Transglycosylase; Region: Transgly; pfam00912 568703005083 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 568703005084 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 568703005085 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 568703005086 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 568703005087 active site 568703005088 Arginine repressor [Transcription]; Region: ArgR; COG1438 568703005089 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 568703005090 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 568703005091 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 568703005092 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 568703005093 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 568703005094 active site 568703005095 HIGH motif; other site 568703005096 KMSK motif region; other site 568703005097 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 568703005098 tRNA binding surface [nucleotide binding]; other site 568703005099 anticodon binding site; other site 568703005100 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 568703005101 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 568703005102 active site 568703005103 FMN binding site [chemical binding]; other site 568703005104 substrate binding site [chemical binding]; other site 568703005105 catalytic residues [active] 568703005106 homodimer interface [polypeptide binding]; other site 568703005107 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 568703005108 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 568703005109 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 568703005110 putative active site [active] 568703005111 catalytic site [active] 568703005112 putative metal binding site [ion binding]; other site 568703005113 adaptor protein; Provisional; Region: PRK02315 568703005114 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 568703005115 ArsC family; Region: ArsC; pfam03960 568703005116 putative catalytic residues [active] 568703005117 thiol/disulfide switch; other site 568703005118 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 568703005119 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 568703005120 FtsX-like permease family; Region: FtsX; pfam02687 568703005121 FtsX-like permease family; Region: FtsX; pfam02687 568703005122 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703005123 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568703005124 Walker A/P-loop; other site 568703005125 ATP binding site [chemical binding]; other site 568703005126 Q-loop/lid; other site 568703005127 ABC transporter signature motif; other site 568703005128 Walker B; other site 568703005129 D-loop; other site 568703005130 H-loop/switch region; other site 568703005131 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703005132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703005133 active site 568703005134 phosphorylation site [posttranslational modification] 568703005135 intermolecular recognition site; other site 568703005136 dimerization interface [polypeptide binding]; other site 568703005137 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703005138 DNA binding site [nucleotide binding] 568703005139 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703005140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703005141 ATP binding site [chemical binding]; other site 568703005142 Mg2+ binding site [ion binding]; other site 568703005143 G-X-G motif; other site 568703005144 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 568703005145 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 568703005146 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 568703005147 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703005148 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 568703005149 Penicillinase repressor; Region: Pencillinase_R; pfam03965 568703005150 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 568703005151 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 568703005152 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568703005153 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 568703005154 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 568703005155 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 568703005156 purine monophosphate binding site [chemical binding]; other site 568703005157 dimer interface [polypeptide binding]; other site 568703005158 putative catalytic residues [active] 568703005159 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 568703005160 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 568703005161 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 568703005162 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 568703005163 active site 568703005164 substrate binding site [chemical binding]; other site 568703005165 cosubstrate binding site; other site 568703005166 catalytic site [active] 568703005167 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 568703005168 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 568703005169 dimerization interface [polypeptide binding]; other site 568703005170 putative ATP binding site [chemical binding]; other site 568703005171 amidophosphoribosyltransferase; Provisional; Region: PRK07272 568703005172 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 568703005173 active site 568703005174 tetramer interface [polypeptide binding]; other site 568703005175 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703005176 active site 568703005177 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 568703005178 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 568703005179 dimerization interface [polypeptide binding]; other site 568703005180 ATP binding site [chemical binding]; other site 568703005181 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 568703005182 dimerization interface [polypeptide binding]; other site 568703005183 ATP binding site [chemical binding]; other site 568703005184 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 568703005185 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 568703005186 putative active site [active] 568703005187 catalytic triad [active] 568703005188 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 568703005189 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 568703005190 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 568703005191 ATP binding site [chemical binding]; other site 568703005192 active site 568703005193 substrate binding site [chemical binding]; other site 568703005194 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 568703005195 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 568703005196 NAD binding site [chemical binding]; other site 568703005197 ATP-grasp domain; Region: ATP-grasp; pfam02222 568703005198 AIR carboxylase; Region: AIRC; pfam00731 568703005199 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 568703005200 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 568703005201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005202 putative substrate translocation pore; other site 568703005203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005204 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 568703005205 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 568703005206 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 568703005207 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 568703005208 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 568703005209 dimerization domain swap beta strand [polypeptide binding]; other site 568703005210 regulatory protein interface [polypeptide binding]; other site 568703005211 active site 568703005212 regulatory phosphorylation site [posttranslational modification]; other site 568703005213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703005214 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 568703005215 Walker A motif; other site 568703005216 ATP binding site [chemical binding]; other site 568703005217 Walker B motif; other site 568703005218 arginine finger; other site 568703005219 UvrB/uvrC motif; Region: UVR; pfam02151 568703005220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703005221 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 568703005222 Walker A motif; other site 568703005223 ATP binding site [chemical binding]; other site 568703005224 Walker B motif; other site 568703005225 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 568703005226 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 568703005227 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 568703005228 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 568703005229 G1 box; other site 568703005230 putative GEF interaction site [polypeptide binding]; other site 568703005231 GTP/Mg2+ binding site [chemical binding]; other site 568703005232 Switch I region; other site 568703005233 G2 box; other site 568703005234 G3 box; other site 568703005235 Switch II region; other site 568703005236 G4 box; other site 568703005237 G5 box; other site 568703005238 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 568703005239 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 568703005240 Domain of unknown function DUF21; Region: DUF21; pfam01595 568703005241 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568703005242 Transporter associated domain; Region: CorC_HlyC; pfam03471 568703005243 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 568703005244 Domain of unknown function DUF20; Region: UPF0118; pfam01594 568703005245 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703005246 Coenzyme A binding pocket [chemical binding]; other site 568703005247 hypothetical protein; Provisional; Region: PRK13662 568703005248 RecX family; Region: RecX; cl00936 568703005249 Mga helix-turn-helix domain; Region: Mga; pfam05043 568703005250 TRAM domain; Region: TRAM; pfam01938 568703005251 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 568703005252 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 568703005253 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 568703005254 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 568703005255 PYR/PP interface [polypeptide binding]; other site 568703005256 dimer interface [polypeptide binding]; other site 568703005257 tetramer interface [polypeptide binding]; other site 568703005258 TPP binding site [chemical binding]; other site 568703005259 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568703005260 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 568703005261 TPP-binding site [chemical binding]; other site 568703005262 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 568703005263 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 568703005264 dimer interface [polypeptide binding]; other site 568703005265 active site 568703005266 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 568703005267 homodimer interface [polypeptide binding]; other site 568703005268 catalytic residues [active] 568703005269 NAD binding site [chemical binding]; other site 568703005270 substrate binding pocket [chemical binding]; other site 568703005271 flexible flap; other site 568703005272 putative acyltransferase; Provisional; Region: PRK05790 568703005273 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568703005274 dimer interface [polypeptide binding]; other site 568703005275 active site 568703005276 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 568703005277 Restriction endonuclease; Region: Mrr_cat; pfam04471 568703005278 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 568703005279 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 568703005280 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 568703005281 metal binding site [ion binding]; metal-binding site 568703005282 dimer interface [polypeptide binding]; other site 568703005283 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 568703005284 Predicted membrane protein [Function unknown]; Region: COG4684 568703005285 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 568703005286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703005287 Coenzyme A binding pocket [chemical binding]; other site 568703005288 SprT homologues; Region: SprT; cl01182 568703005289 SprT-like family; Region: SprT-like; pfam10263 568703005290 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 568703005291 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703005292 Walker A/P-loop; other site 568703005293 ATP binding site [chemical binding]; other site 568703005294 Q-loop/lid; other site 568703005295 ABC transporter signature motif; other site 568703005296 Walker B; other site 568703005297 D-loop; other site 568703005298 H-loop/switch region; other site 568703005299 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 568703005300 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568703005301 TM-ABC transporter signature motif; other site 568703005302 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 568703005303 zinc binding site [ion binding]; other site 568703005304 putative ligand binding site [chemical binding]; other site 568703005305 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 568703005306 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 568703005307 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703005308 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 568703005309 Soluble P-type ATPase [General function prediction only]; Region: COG4087 568703005310 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568703005311 Beta-lactamase; Region: Beta-lactamase; pfam00144 568703005312 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568703005313 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 568703005314 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 568703005315 homodimer interface [polypeptide binding]; other site 568703005316 NAD binding pocket [chemical binding]; other site 568703005317 ATP binding pocket [chemical binding]; other site 568703005318 Mg binding site [ion binding]; other site 568703005319 active-site loop [active] 568703005320 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568703005321 Beta-lactamase; Region: Beta-lactamase; pfam00144 568703005322 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 568703005323 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 568703005324 active site 568703005325 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703005326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703005327 DNA-binding site [nucleotide binding]; DNA binding site 568703005328 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 568703005329 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 568703005330 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 568703005331 active site 568703005332 dimer interface [polypeptide binding]; other site 568703005333 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 568703005334 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 568703005335 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 568703005336 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 568703005337 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 568703005338 Mga helix-turn-helix domain; Region: Mga; pfam05043 568703005339 putative phosphoesterase; Region: acc_ester; TIGR03729 568703005340 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568703005341 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 568703005342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005343 putative substrate translocation pore; other site 568703005344 POT family; Region: PTR2; pfam00854 568703005345 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703005346 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568703005347 Walker A/P-loop; other site 568703005348 ATP binding site [chemical binding]; other site 568703005349 Q-loop/lid; other site 568703005350 ABC transporter signature motif; other site 568703005351 Walker B; other site 568703005352 D-loop; other site 568703005353 H-loop/switch region; other site 568703005354 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 568703005355 FtsX-like permease family; Region: FtsX; pfam02687 568703005356 MFS/sugar transport protein; Region: MFS_2; pfam13347 568703005357 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 568703005358 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 568703005359 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 568703005360 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 568703005361 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 568703005362 active site 568703005363 nucleotide-binding site [chemical binding]; other site 568703005364 Virus attachment protein p12 family; Region: P12; pfam12669 568703005365 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 568703005366 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 568703005367 G1 box; other site 568703005368 GTP/Mg2+ binding site [chemical binding]; other site 568703005369 Switch I region; other site 568703005370 G2 box; other site 568703005371 G3 box; other site 568703005372 Switch II region; other site 568703005373 G4 box; other site 568703005374 G5 box; other site 568703005375 Nucleoside recognition; Region: Gate; pfam07670 568703005376 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 568703005377 Nucleoside recognition; Region: Gate; pfam07670 568703005378 FeoA domain; Region: FeoA; pfam04023 568703005379 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 568703005380 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 568703005381 catalytic triad [active] 568703005382 catalytic triad [active] 568703005383 oxyanion hole [active] 568703005384 AAA domain; Region: AAA_18; pfam13238 568703005385 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 568703005386 NADH(P)-binding; Region: NAD_binding_10; pfam13460 568703005387 NAD binding site [chemical binding]; other site 568703005388 substrate binding site [chemical binding]; other site 568703005389 putative active site [active] 568703005390 seryl-tRNA synthetase; Provisional; Region: PRK05431 568703005391 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 568703005392 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 568703005393 dimer interface [polypeptide binding]; other site 568703005394 active site 568703005395 motif 1; other site 568703005396 motif 2; other site 568703005397 motif 3; other site 568703005398 Mga helix-turn-helix domain; Region: Mga; pfam05043 568703005399 Mga helix-turn-helix domain; Region: Mga; pfam05043 568703005400 lysine transporter; Provisional; Region: PRK10836 568703005401 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 568703005402 acetolactate synthase; Reviewed; Region: PRK08617 568703005403 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568703005404 PYR/PP interface [polypeptide binding]; other site 568703005405 dimer interface [polypeptide binding]; other site 568703005406 TPP binding site [chemical binding]; other site 568703005407 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568703005408 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 568703005409 TPP-binding site [chemical binding]; other site 568703005410 dimer interface [polypeptide binding]; other site 568703005411 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568703005412 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 568703005413 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 568703005414 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 568703005415 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 568703005416 Fic family protein [Function unknown]; Region: COG3177 568703005417 Fic/DOC family; Region: Fic; pfam02661 568703005418 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 568703005419 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 568703005420 active site 568703005421 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 568703005422 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 568703005423 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 568703005424 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568703005425 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703005426 DNA-binding site [nucleotide binding]; DNA binding site 568703005427 FCD domain; Region: FCD; pfam07729 568703005428 oxaloacetate decarboxylase; Provisional; Region: PRK12331 568703005429 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 568703005430 active site 568703005431 catalytic residues [active] 568703005432 metal binding site [ion binding]; metal-binding site 568703005433 homodimer binding site [polypeptide binding]; other site 568703005434 2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392 568703005435 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 568703005436 Coenzyme A transferase; Region: CoA_trans; cl17247 568703005437 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 568703005438 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 568703005439 citrate lyase subunit gamma; Provisional; Region: PRK13253 568703005440 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 568703005441 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568703005442 active site 568703005443 nucleotide binding site [chemical binding]; other site 568703005444 HIGH motif; other site 568703005445 KMSKS motif; other site 568703005446 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 568703005447 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568703005448 carboxyltransferase (CT) interaction site; other site 568703005449 biotinylation site [posttranslational modification]; other site 568703005450 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 568703005451 Citrate transporter; Region: CitMHS; pfam03600 568703005452 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 568703005453 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 568703005454 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 568703005455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703005456 Coenzyme A binding pocket [chemical binding]; other site 568703005457 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 568703005458 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 568703005459 Predicted transcriptional regulators [Transcription]; Region: COG1695 568703005460 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 568703005461 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 568703005462 dimer interface [polypeptide binding]; other site 568703005463 FMN binding site [chemical binding]; other site 568703005464 NADPH bind site [chemical binding]; other site 568703005465 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703005466 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703005467 Walker A/P-loop; other site 568703005468 ATP binding site [chemical binding]; other site 568703005469 Q-loop/lid; other site 568703005470 ABC transporter signature motif; other site 568703005471 Walker B; other site 568703005472 D-loop; other site 568703005473 H-loop/switch region; other site 568703005474 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 568703005475 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703005476 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703005477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005478 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703005479 putative substrate translocation pore; other site 568703005480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005481 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568703005482 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703005483 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703005484 non-specific DNA binding site [nucleotide binding]; other site 568703005485 salt bridge; other site 568703005486 sequence-specific DNA binding site [nucleotide binding]; other site 568703005487 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 568703005488 Predicted transcriptional regulators [Transcription]; Region: COG1725 568703005489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703005490 DNA-binding site [nucleotide binding]; DNA binding site 568703005491 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568703005492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703005493 Walker A/P-loop; other site 568703005494 ATP binding site [chemical binding]; other site 568703005495 Q-loop/lid; other site 568703005496 ABC transporter signature motif; other site 568703005497 Walker B; other site 568703005498 D-loop; other site 568703005499 H-loop/switch region; other site 568703005500 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568703005501 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568703005502 Walker A/P-loop; other site 568703005503 ATP binding site [chemical binding]; other site 568703005504 Q-loop/lid; other site 568703005505 ABC transporter signature motif; other site 568703005506 Walker B; other site 568703005507 D-loop; other site 568703005508 H-loop/switch region; other site 568703005509 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568703005510 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568703005511 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568703005512 Walker A/P-loop; other site 568703005513 ATP binding site [chemical binding]; other site 568703005514 Q-loop/lid; other site 568703005515 ABC transporter signature motif; other site 568703005516 Walker B; other site 568703005517 D-loop; other site 568703005518 H-loop/switch region; other site 568703005519 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568703005520 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 568703005521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703005522 dimer interface [polypeptide binding]; other site 568703005523 conserved gate region; other site 568703005524 putative PBP binding loops; other site 568703005525 ABC-ATPase subunit interface; other site 568703005526 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568703005527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703005528 dimer interface [polypeptide binding]; other site 568703005529 conserved gate region; other site 568703005530 putative PBP binding loops; other site 568703005531 ABC-ATPase subunit interface; other site 568703005532 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568703005533 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568703005534 peptide binding site [polypeptide binding]; other site 568703005535 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703005536 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703005537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703005538 Walker A/P-loop; other site 568703005539 ATP binding site [chemical binding]; other site 568703005540 Q-loop/lid; other site 568703005541 ABC transporter signature motif; other site 568703005542 Walker B; other site 568703005543 D-loop; other site 568703005544 H-loop/switch region; other site 568703005545 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703005546 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703005547 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568703005548 Walker A/P-loop; other site 568703005549 ATP binding site [chemical binding]; other site 568703005550 Q-loop/lid; other site 568703005551 ABC transporter signature motif; other site 568703005552 Walker B; other site 568703005553 D-loop; other site 568703005554 H-loop/switch region; other site 568703005555 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 568703005556 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 568703005557 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703005558 ATP binding site [chemical binding]; other site 568703005559 putative Mg++ binding site [ion binding]; other site 568703005560 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 568703005561 nucleotide binding region [chemical binding]; other site 568703005562 ATP-binding site [chemical binding]; other site 568703005563 Phosphotransferase enzyme family; Region: APH; pfam01636 568703005564 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 568703005565 substrate binding site [chemical binding]; other site 568703005566 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 568703005567 active site 568703005568 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568703005569 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703005570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703005571 non-specific DNA binding site [nucleotide binding]; other site 568703005572 salt bridge; other site 568703005573 sequence-specific DNA binding site [nucleotide binding]; other site 568703005574 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 568703005575 putative active site [active] 568703005576 putative NTP binding site [chemical binding]; other site 568703005577 putative nucleic acid binding site [nucleotide binding]; other site 568703005578 Transposase domain (DUF772); Region: DUF772; pfam05598 568703005579 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703005580 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703005581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 568703005582 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 568703005583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 568703005584 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 568703005585 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 568703005586 Transposase domain (DUF772); Region: DUF772; pfam05598 568703005587 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703005588 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 568703005589 GMP synthase; Reviewed; Region: guaA; PRK00074 568703005590 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 568703005591 AMP/PPi binding site [chemical binding]; other site 568703005592 candidate oxyanion hole; other site 568703005593 catalytic triad [active] 568703005594 potential glutamine specificity residues [chemical binding]; other site 568703005595 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 568703005596 ATP Binding subdomain [chemical binding]; other site 568703005597 Dimerization subdomain; other site 568703005598 pantothenate kinase; Provisional; Region: PRK05439 568703005599 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 568703005600 ATP-binding site [chemical binding]; other site 568703005601 CoA-binding site [chemical binding]; other site 568703005602 Mg2+-binding site [ion binding]; other site 568703005603 Peptidase family C69; Region: Peptidase_C69; pfam03577 568703005604 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 568703005605 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 568703005606 Part of AAA domain; Region: AAA_19; pfam13245 568703005607 Family description; Region: UvrD_C_2; pfam13538 568703005608 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 568703005609 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 568703005610 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 568703005611 TrkA-C domain; Region: TrkA_C; pfam02080 568703005612 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 568703005613 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 568703005614 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 568703005615 Ferrochelatase; Region: Ferrochelatase; pfam00762 568703005616 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 568703005617 C-terminal domain interface [polypeptide binding]; other site 568703005618 active site 568703005619 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 568703005620 active site 568703005621 N-terminal domain interface [polypeptide binding]; other site 568703005622 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703005623 catalytic core [active] 568703005624 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703005625 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 568703005626 intersubunit interface [polypeptide binding]; other site 568703005627 active site 568703005628 Zn2+ binding site [ion binding]; other site 568703005629 FtsX-like permease family; Region: FtsX; pfam02687 568703005630 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703005631 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568703005632 Walker A/P-loop; other site 568703005633 ATP binding site [chemical binding]; other site 568703005634 Q-loop/lid; other site 568703005635 ABC transporter signature motif; other site 568703005636 Walker B; other site 568703005637 D-loop; other site 568703005638 H-loop/switch region; other site 568703005639 Amino acid permease; Region: AA_permease_2; pfam13520 568703005640 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 568703005641 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 568703005642 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 568703005643 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 568703005644 HflX GTPase family; Region: HflX; cd01878 568703005645 G1 box; other site 568703005646 GTP/Mg2+ binding site [chemical binding]; other site 568703005647 Switch I region; other site 568703005648 G2 box; other site 568703005649 G3 box; other site 568703005650 Switch II region; other site 568703005651 G4 box; other site 568703005652 G5 box; other site 568703005653 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 568703005654 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 568703005655 NodB motif; other site 568703005656 active site 568703005657 catalytic site [active] 568703005658 Zn binding site [ion binding]; other site 568703005659 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 568703005660 active site 568703005661 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 568703005662 homodimer interface [polypeptide binding]; other site 568703005663 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 568703005664 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 568703005665 NADP binding site [chemical binding]; other site 568703005666 active site 568703005667 putative substrate binding site [chemical binding]; other site 568703005668 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 568703005669 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 568703005670 NAD binding site [chemical binding]; other site 568703005671 substrate binding site [chemical binding]; other site 568703005672 homodimer interface [polypeptide binding]; other site 568703005673 active site 568703005674 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 568703005675 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 568703005676 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 568703005677 substrate binding site; other site 568703005678 tetramer interface; other site 568703005679 SH3-like domain; Region: SH3_8; pfam13457 568703005680 SH3-like domain; Region: SH3_8; pfam13457 568703005681 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 568703005682 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 568703005683 active site 568703005684 SH3-like domain; Region: SH3_8; pfam13457 568703005685 SH3-like domain; Region: SH3_8; pfam13457 568703005686 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 568703005687 Transposase domain (DUF772); Region: DUF772; pfam05598 568703005688 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703005689 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 568703005690 Bacterial sugar transferase; Region: Bac_transf; pfam02397 568703005691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703005692 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 568703005693 NAD(P) binding site [chemical binding]; other site 568703005694 active site 568703005695 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703005696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703005697 dimer interface [polypeptide binding]; other site 568703005698 conserved gate region; other site 568703005699 putative PBP binding loops; other site 568703005700 ABC-ATPase subunit interface; other site 568703005701 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703005702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703005703 dimer interface [polypeptide binding]; other site 568703005704 conserved gate region; other site 568703005705 putative PBP binding loops; other site 568703005706 ABC-ATPase subunit interface; other site 568703005707 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703005708 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703005709 substrate binding pocket [chemical binding]; other site 568703005710 membrane-bound complex binding site; other site 568703005711 hinge residues; other site 568703005712 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568703005713 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568703005714 Walker A/P-loop; other site 568703005715 ATP binding site [chemical binding]; other site 568703005716 Q-loop/lid; other site 568703005717 ABC transporter signature motif; other site 568703005718 Walker B; other site 568703005719 D-loop; other site 568703005720 H-loop/switch region; other site 568703005721 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 568703005722 metal binding site 2 [ion binding]; metal-binding site 568703005723 putative DNA binding helix; other site 568703005724 metal binding site 1 [ion binding]; metal-binding site 568703005725 dimer interface [polypeptide binding]; other site 568703005726 structural Zn2+ binding site [ion binding]; other site 568703005727 Guanylate kinase; Region: Guanylate_kin; pfam00625 568703005728 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 568703005729 catalytic site [active] 568703005730 G-X2-G-X-G-K; other site 568703005731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703005732 Coenzyme A binding pocket [chemical binding]; other site 568703005733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 568703005734 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 568703005735 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 568703005736 NlpC/P60 family; Region: NLPC_P60; pfam00877 568703005737 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 568703005738 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 568703005739 active site 568703005740 HIGH motif; other site 568703005741 dimer interface [polypeptide binding]; other site 568703005742 KMSKS motif; other site 568703005743 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703005744 RNA binding surface [nucleotide binding]; other site 568703005745 Cation efflux family; Region: Cation_efflux; cl00316 568703005746 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 568703005747 Cation efflux family; Region: Cation_efflux; cl00316 568703005748 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568703005749 dimerization interface [polypeptide binding]; other site 568703005750 putative DNA binding site [nucleotide binding]; other site 568703005751 putative Zn2+ binding site [ion binding]; other site 568703005752 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 568703005753 ApbE family; Region: ApbE; pfam02424 568703005754 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 568703005755 active site 568703005756 homodimer interface [polypeptide binding]; other site 568703005757 catalytic site [active] 568703005758 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 568703005759 homodimer interface [polypeptide binding]; other site 568703005760 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 568703005761 active site pocket [active] 568703005762 glycogen synthase; Provisional; Region: glgA; PRK00654 568703005763 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 568703005764 ADP-binding pocket [chemical binding]; other site 568703005765 homodimer interface [polypeptide binding]; other site 568703005766 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 568703005767 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568703005768 active site 568703005769 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 568703005770 dimer interface [polypeptide binding]; other site 568703005771 N-terminal domain interface [polypeptide binding]; other site 568703005772 sulfate 1 binding site; other site 568703005773 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 568703005774 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 568703005775 ligand binding site; other site 568703005776 oligomer interface; other site 568703005777 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 568703005778 dimer interface [polypeptide binding]; other site 568703005779 N-terminal domain interface [polypeptide binding]; other site 568703005780 sulfate 1 binding site; other site 568703005781 glycogen branching enzyme; Provisional; Region: PRK12313 568703005782 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 568703005783 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 568703005784 active site 568703005785 catalytic site [active] 568703005786 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 568703005787 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 568703005788 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 568703005789 homodimer interface [polypeptide binding]; other site 568703005790 substrate-cofactor binding pocket; other site 568703005791 catalytic residue [active] 568703005792 Sortase family; Region: Sortase; pfam04203 568703005793 Uncharacterized conserved protein [Function unknown]; Region: COG1284 568703005794 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 568703005795 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 568703005796 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 568703005797 Transposase domain (DUF772); Region: DUF772; pfam05598 568703005798 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703005799 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 568703005800 ArsC family; Region: ArsC; pfam03960 568703005801 putative catalytic residues [active] 568703005802 thiol/disulfide switch; other site 568703005803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703005804 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 568703005805 Walker A motif; other site 568703005806 ATP binding site [chemical binding]; other site 568703005807 Walker B motif; other site 568703005808 arginine finger; other site 568703005809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703005810 Walker A motif; other site 568703005811 ATP binding site [chemical binding]; other site 568703005812 Walker B motif; other site 568703005813 arginine finger; other site 568703005814 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 568703005815 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 568703005816 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 568703005817 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 568703005818 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 568703005819 NAD binding site [chemical binding]; other site 568703005820 substrate binding site [chemical binding]; other site 568703005821 homodimer interface [polypeptide binding]; other site 568703005822 active site 568703005823 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 568703005824 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568703005825 Transposase domain (DUF772); Region: DUF772; pfam05598 568703005826 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703005827 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568703005828 active site 568703005829 Bacterial sugar transferase; Region: Bac_transf; pfam02397 568703005830 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 568703005831 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703005832 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 568703005833 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568703005834 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 568703005835 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 568703005836 Probable Catalytic site; other site 568703005837 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703005838 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 568703005839 putative ADP-binding pocket [chemical binding]; other site 568703005840 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 568703005841 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 568703005842 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 568703005843 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 568703005844 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568703005845 UDP-galactopyranose mutase; Region: GLF; pfam03275 568703005846 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 568703005847 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 568703005848 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 568703005849 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 568703005850 Chain length determinant protein; Region: Wzz; cl15801 568703005851 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 568703005852 catalytic triad [active] 568703005853 catalytic triad [active] 568703005854 oxyanion hole [active] 568703005855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703005856 non-specific DNA binding site [nucleotide binding]; other site 568703005857 salt bridge; other site 568703005858 sequence-specific DNA binding site [nucleotide binding]; other site 568703005859 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 568703005860 QueT transporter; Region: QueT; pfam06177 568703005861 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 568703005862 classical (c) SDRs; Region: SDR_c; cd05233 568703005863 NAD(P) binding site [chemical binding]; other site 568703005864 active site 568703005865 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 568703005866 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703005867 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703005868 non-specific DNA binding site [nucleotide binding]; other site 568703005869 salt bridge; other site 568703005870 sequence-specific DNA binding site [nucleotide binding]; other site 568703005871 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703005872 catalytic core [active] 568703005873 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568703005874 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568703005875 Walker A/P-loop; other site 568703005876 ATP binding site [chemical binding]; other site 568703005877 Q-loop/lid; other site 568703005878 ABC transporter signature motif; other site 568703005879 Walker B; other site 568703005880 D-loop; other site 568703005881 H-loop/switch region; other site 568703005882 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568703005883 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568703005884 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568703005885 Walker A/P-loop; other site 568703005886 ATP binding site [chemical binding]; other site 568703005887 Q-loop/lid; other site 568703005888 ABC transporter signature motif; other site 568703005889 Walker B; other site 568703005890 D-loop; other site 568703005891 H-loop/switch region; other site 568703005892 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 568703005893 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 568703005894 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 568703005895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703005896 dimer interface [polypeptide binding]; other site 568703005897 conserved gate region; other site 568703005898 putative PBP binding loops; other site 568703005899 ABC-ATPase subunit interface; other site 568703005900 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568703005901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703005902 dimer interface [polypeptide binding]; other site 568703005903 conserved gate region; other site 568703005904 putative PBP binding loops; other site 568703005905 ABC-ATPase subunit interface; other site 568703005906 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568703005907 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568703005908 peptide binding site [polypeptide binding]; other site 568703005909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005910 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703005911 putative substrate translocation pore; other site 568703005912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005913 elongation factor P; Validated; Region: PRK00529 568703005914 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 568703005915 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 568703005916 RNA binding site [nucleotide binding]; other site 568703005917 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 568703005918 RNA binding site [nucleotide binding]; other site 568703005919 Uncharacterized conserved protein [Function unknown]; Region: COG1556 568703005920 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 568703005921 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 568703005922 4Fe-4S binding domain; Region: Fer4; pfam00037 568703005923 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 568703005924 Cysteine-rich domain; Region: CCG; pfam02754 568703005925 Cysteine-rich domain; Region: CCG; pfam02754 568703005926 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 568703005927 active site 568703005928 methionine cluster; other site 568703005929 phosphorylation site [posttranslational modification] 568703005930 metal binding site [ion binding]; metal-binding site 568703005931 Uncharacterized conserved protein [Function unknown]; Region: COG3589 568703005932 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 568703005933 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 568703005934 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 568703005935 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 568703005936 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 568703005937 Melibiase; Region: Melibiase; pfam02065 568703005938 hypothetical protein; Validated; Region: PRK02101 568703005939 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568703005940 DNA binding residues [nucleotide binding] 568703005941 Winged helix-turn helix; Region: HTH_29; pfam13551 568703005942 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 568703005943 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 568703005944 AAA domain; Region: AAA_30; pfam13604 568703005945 Family description; Region: UvrD_C_2; pfam13538 568703005946 WxL domain surface cell wall-binding; Region: WxL; pfam13731 568703005947 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568703005948 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 568703005949 substrate binding site [chemical binding]; other site 568703005950 ATP binding site [chemical binding]; other site 568703005951 Predicted periplasmic protein [Function unknown]; Region: COG3698 568703005952 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 568703005953 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 568703005954 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 568703005955 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568703005956 active site 568703005957 metal binding site [ion binding]; metal-binding site 568703005958 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 568703005959 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 568703005960 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 568703005961 Uncharacterized conserved protein [Function unknown]; Region: COG3535 568703005962 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 568703005963 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 568703005964 Na binding site [ion binding]; other site 568703005965 Protein of unknown function DUF262; Region: DUF262; pfam03235 568703005966 Uncharacterized conserved protein [Function unknown]; Region: COG1479 568703005967 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 568703005968 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 568703005969 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 568703005970 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 568703005971 TIGR02687 family protein; Region: TIGR02687 568703005972 PglZ domain; Region: PglZ; pfam08665 568703005973 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 568703005974 integrase; Provisional; Region: int; PHA02601 568703005975 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 568703005976 Int/Topo IB signature motif; other site 568703005977 Methyltransferase domain; Region: Methyltransf_26; pfam13659 568703005978 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 568703005979 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 568703005980 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 568703005981 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 568703005982 Protein of unknown function (DUF998); Region: DUF998; pfam06197 568703005983 Predicted membrane protein [Function unknown]; Region: COG3371 568703005984 Predicted membrane protein [Function unknown]; Region: COG1511 568703005985 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 568703005986 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 568703005987 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568703005988 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 568703005989 HPr interaction site; other site 568703005990 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568703005991 active site 568703005992 phosphorylation site [posttranslational modification] 568703005993 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 568703005994 active site turn [active] 568703005995 phosphorylation site [posttranslational modification] 568703005996 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568703005997 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 568703005998 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 568703005999 Ca binding site [ion binding]; other site 568703006000 active site 568703006001 catalytic site [active] 568703006002 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568703006003 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568703006004 DNA binding site [nucleotide binding] 568703006005 domain linker motif; other site 568703006006 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 568703006007 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 568703006008 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 568703006009 substrate binding [chemical binding]; other site 568703006010 active site 568703006011 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 568703006012 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 568703006013 NmrA-like family; Region: NmrA; pfam05368 568703006014 NADP binding site [chemical binding]; other site 568703006015 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 568703006016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703006017 S-adenosylmethionine binding site [chemical binding]; other site 568703006018 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 568703006019 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 568703006020 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 568703006021 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 568703006022 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568703006023 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568703006024 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 568703006025 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 568703006026 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568703006027 carboxyltransferase (CT) interaction site; other site 568703006028 biotinylation site [posttranslational modification]; other site 568703006029 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 568703006030 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 568703006031 dimer interface [polypeptide binding]; other site 568703006032 active site 568703006033 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 568703006034 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 568703006035 NAD(P) binding site [chemical binding]; other site 568703006036 homotetramer interface [polypeptide binding]; other site 568703006037 homodimer interface [polypeptide binding]; other site 568703006038 active site 568703006039 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 568703006040 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 568703006041 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 568703006042 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 568703006043 FMN binding site [chemical binding]; other site 568703006044 substrate binding site [chemical binding]; other site 568703006045 putative catalytic residue [active] 568703006046 acyl carrier protein; Provisional; Region: acpP; PRK00982 568703006047 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 568703006048 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 568703006049 dimer interface [polypeptide binding]; other site 568703006050 active site 568703006051 CoA binding pocket [chemical binding]; other site 568703006052 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568703006053 MarR family; Region: MarR_2; pfam12802 568703006054 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 568703006055 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 568703006056 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 568703006057 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 568703006058 dimer interface [polypeptide binding]; other site 568703006059 active site 568703006060 metal binding site [ion binding]; metal-binding site 568703006061 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 568703006062 active site residue [active] 568703006063 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568703006064 MarR family; Region: MarR_2; pfam12802 568703006065 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568703006066 MarR family; Region: MarR_2; pfam12802 568703006067 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 568703006068 Putative esterase; Region: Esterase; pfam00756 568703006069 S-formylglutathione hydrolase; Region: PLN02442 568703006070 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 568703006071 Double zinc ribbon; Region: DZR; pfam12773 568703006072 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568703006073 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568703006074 putative Zn2+ binding site [ion binding]; other site 568703006075 putative DNA binding site [nucleotide binding]; other site 568703006076 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 568703006077 nudix motif; other site 568703006078 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703006079 catalytic core [active] 568703006080 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703006081 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568703006082 Beta-lactamase; Region: Beta-lactamase; pfam00144 568703006083 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 568703006084 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 568703006085 active site 568703006086 catalytic site [active] 568703006087 Predicted membrane protein [Function unknown]; Region: COG2246 568703006088 GtrA-like protein; Region: GtrA; pfam04138 568703006089 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 568703006090 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 568703006091 PYR/PP interface [polypeptide binding]; other site 568703006092 tetramer interface [polypeptide binding]; other site 568703006093 dimer interface [polypeptide binding]; other site 568703006094 TPP binding site [chemical binding]; other site 568703006095 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568703006096 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 568703006097 TPP-binding site [chemical binding]; other site 568703006098 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 568703006099 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 568703006100 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 568703006101 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 568703006102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703006103 dimer interface [polypeptide binding]; other site 568703006104 conserved gate region; other site 568703006105 putative PBP binding loops; other site 568703006106 ABC-ATPase subunit interface; other site 568703006107 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 568703006108 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 568703006109 Walker A/P-loop; other site 568703006110 ATP binding site [chemical binding]; other site 568703006111 Q-loop/lid; other site 568703006112 ABC transporter signature motif; other site 568703006113 Walker B; other site 568703006114 D-loop; other site 568703006115 H-loop/switch region; other site 568703006116 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 568703006117 Sugar fermentation stimulation protein; Region: SfsA; cl00647 568703006118 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568703006119 Ligand Binding Site [chemical binding]; other site 568703006120 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 568703006121 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 568703006122 homoserine kinase; Provisional; Region: PRK01212 568703006123 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 568703006124 threonine synthase; Validated; Region: PRK09225 568703006125 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 568703006126 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703006127 catalytic residue [active] 568703006128 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 568703006129 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 568703006130 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 568703006131 aspartate kinase; Reviewed; Region: PRK09034 568703006132 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 568703006133 nucleotide binding site [chemical binding]; other site 568703006134 substrate binding site [chemical binding]; other site 568703006135 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 568703006136 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 568703006137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 568703006138 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 568703006139 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 568703006140 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 568703006141 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703006142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703006143 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568703006144 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 568703006145 D-lactate dehydrogenase; Validated; Region: PRK08605 568703006146 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 568703006147 homodimer interface [polypeptide binding]; other site 568703006148 ligand binding site [chemical binding]; other site 568703006149 NAD binding site [chemical binding]; other site 568703006150 catalytic site [active] 568703006151 aromatic amino acid aminotransferase; Validated; Region: PRK07309 568703006152 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703006153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703006154 homodimer interface [polypeptide binding]; other site 568703006155 catalytic residue [active] 568703006156 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 568703006157 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703006158 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703006159 Uncharacterized conserved protein [Function unknown]; Region: COG2013 568703006160 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568703006161 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703006162 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 568703006163 Predicted membrane protein [Function unknown]; Region: COG1511 568703006164 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 568703006165 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 568703006166 Transposase domain (DUF772); Region: DUF772; pfam05598 568703006167 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703006168 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 568703006169 Cation efflux family; Region: Cation_efflux; pfam01545 568703006170 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 568703006171 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 568703006172 active site 568703006173 dimer interface [polypeptide binding]; other site 568703006174 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 568703006175 Ligand Binding Site [chemical binding]; other site 568703006176 Molecular Tunnel; other site 568703006177 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 568703006178 HNH endonuclease; Region: HNH_5; pfam14279 568703006179 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 568703006180 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 568703006181 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568703006182 active site 568703006183 metal binding site [ion binding]; metal-binding site 568703006184 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 568703006185 UbiA prenyltransferase family; Region: UbiA; pfam01040 568703006186 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 568703006187 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 568703006188 substrate binding pocket [chemical binding]; other site 568703006189 chain length determination region; other site 568703006190 substrate-Mg2+ binding site; other site 568703006191 catalytic residues [active] 568703006192 aspartate-rich region 1; other site 568703006193 active site lid residues [active] 568703006194 aspartate-rich region 2; other site 568703006195 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 568703006196 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 568703006197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703006198 Walker A/P-loop; other site 568703006199 ATP binding site [chemical binding]; other site 568703006200 Q-loop/lid; other site 568703006201 ABC transporter signature motif; other site 568703006202 Walker B; other site 568703006203 D-loop; other site 568703006204 H-loop/switch region; other site 568703006205 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 568703006206 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 568703006207 Predicted transcriptional regulators [Transcription]; Region: COG1725 568703006208 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703006209 DNA-binding site [nucleotide binding]; DNA binding site 568703006210 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703006211 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703006212 Walker A/P-loop; other site 568703006213 ATP binding site [chemical binding]; other site 568703006214 Q-loop/lid; other site 568703006215 ABC transporter signature motif; other site 568703006216 Walker B; other site 568703006217 D-loop; other site 568703006218 H-loop/switch region; other site 568703006219 glucose-1-dehydrogenase; Provisional; Region: PRK08936 568703006220 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 568703006221 NAD binding site [chemical binding]; other site 568703006222 homodimer interface [polypeptide binding]; other site 568703006223 active site 568703006224 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 568703006225 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 568703006226 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 568703006227 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 568703006228 active site turn [active] 568703006229 phosphorylation site [posttranslational modification] 568703006230 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568703006231 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 568703006232 HPr interaction site; other site 568703006233 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568703006234 active site 568703006235 phosphorylation site [posttranslational modification] 568703006236 transcriptional antiterminator BglG; Provisional; Region: PRK09772 568703006237 CAT RNA binding domain; Region: CAT_RBD; smart01061 568703006238 PRD domain; Region: PRD; pfam00874 568703006239 PRD domain; Region: PRD; pfam00874 568703006240 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703006241 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703006242 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568703006243 Walker A/P-loop; other site 568703006244 ATP binding site [chemical binding]; other site 568703006245 Q-loop/lid; other site 568703006246 ABC transporter signature motif; other site 568703006247 Walker B; other site 568703006248 D-loop; other site 568703006249 H-loop/switch region; other site 568703006250 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 568703006251 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703006252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703006253 Walker A/P-loop; other site 568703006254 ATP binding site [chemical binding]; other site 568703006255 Q-loop/lid; other site 568703006256 ABC transporter signature motif; other site 568703006257 Walker B; other site 568703006258 D-loop; other site 568703006259 H-loop/switch region; other site 568703006260 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 568703006261 trimer interface [polypeptide binding]; other site 568703006262 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd12218 568703006263 tetramer interface [polypeptide binding]; other site 568703006264 putative DNA binding site [nucleotide binding]; other site 568703006265 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 568703006266 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 568703006267 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 568703006268 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 568703006269 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 568703006270 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703006271 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 568703006272 Walker A/P-loop; other site 568703006273 ATP binding site [chemical binding]; other site 568703006274 Q-loop/lid; other site 568703006275 ABC transporter signature motif; other site 568703006276 Walker B; other site 568703006277 D-loop; other site 568703006278 H-loop/switch region; other site 568703006279 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 568703006280 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703006281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703006282 Walker A/P-loop; other site 568703006283 ATP binding site [chemical binding]; other site 568703006284 Q-loop/lid; other site 568703006285 ABC transporter signature motif; other site 568703006286 Walker B; other site 568703006287 D-loop; other site 568703006288 H-loop/switch region; other site 568703006289 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 568703006290 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 568703006291 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 568703006292 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 568703006293 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 568703006294 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 568703006295 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 568703006296 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 568703006297 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568703006298 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 568703006299 active site 568703006300 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568703006301 EamA-like transporter family; Region: EamA; pfam00892 568703006302 EamA-like transporter family; Region: EamA; pfam00892 568703006303 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 568703006304 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568703006305 Ligand Binding Site [chemical binding]; other site 568703006306 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703006307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703006308 non-specific DNA binding site [nucleotide binding]; other site 568703006309 salt bridge; other site 568703006310 sequence-specific DNA binding site [nucleotide binding]; other site 568703006311 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 568703006312 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 568703006313 epoxyqueuosine reductase; Region: TIGR00276 568703006314 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 568703006315 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 568703006316 protein binding surface [polypeptide binding]; other site 568703006317 BioY family; Region: BioY; pfam02632 568703006318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703006319 S-adenosylmethionine binding site [chemical binding]; other site 568703006320 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 568703006321 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 568703006322 catalytic triad [active] 568703006323 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 568703006324 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 568703006325 Domain of unknown function DUF21; Region: DUF21; pfam01595 568703006326 FOG: CBS domain [General function prediction only]; Region: COG0517 568703006327 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568703006328 Transporter associated domain; Region: CorC_HlyC; smart01091 568703006329 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 568703006330 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 568703006331 Acyltransferase family; Region: Acyl_transf_3; pfam01757 568703006332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006333 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703006334 Maf-like protein; Region: Maf; pfam02545 568703006335 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 568703006336 active site 568703006337 dimer interface [polypeptide binding]; other site 568703006338 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 568703006339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703006340 ATP binding site [chemical binding]; other site 568703006341 Mg2+ binding site [ion binding]; other site 568703006342 G-X-G motif; other site 568703006343 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 568703006344 ATP binding site [chemical binding]; other site 568703006345 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 568703006346 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 568703006347 MutS domain I; Region: MutS_I; pfam01624 568703006348 MutS domain II; Region: MutS_II; pfam05188 568703006349 MutS domain III; Region: MutS_III; pfam05192 568703006350 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 568703006351 Walker A/P-loop; other site 568703006352 ATP binding site [chemical binding]; other site 568703006353 Q-loop/lid; other site 568703006354 ABC transporter signature motif; other site 568703006355 Walker B; other site 568703006356 D-loop; other site 568703006357 H-loop/switch region; other site 568703006358 Amino acid permease; Region: AA_permease_2; pfam13520 568703006359 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 568703006360 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 568703006361 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 568703006362 ring oligomerisation interface [polypeptide binding]; other site 568703006363 ATP/Mg binding site [chemical binding]; other site 568703006364 stacking interactions; other site 568703006365 hinge regions; other site 568703006366 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 568703006367 oligomerisation interface [polypeptide binding]; other site 568703006368 mobile loop; other site 568703006369 roof hairpin; other site 568703006370 CAAX protease self-immunity; Region: Abi; pfam02517 568703006371 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 568703006372 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703006373 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703006374 Walker A/P-loop; other site 568703006375 ATP binding site [chemical binding]; other site 568703006376 Q-loop/lid; other site 568703006377 ABC transporter signature motif; other site 568703006378 Walker B; other site 568703006379 D-loop; other site 568703006380 H-loop/switch region; other site 568703006381 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703006382 DNA-binding site [nucleotide binding]; DNA binding site 568703006383 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 568703006384 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 568703006385 CoA binding domain; Region: CoA_binding; pfam02629 568703006386 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 568703006387 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703006388 Walker A/P-loop; other site 568703006389 ATP binding site [chemical binding]; other site 568703006390 Q-loop/lid; other site 568703006391 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703006392 ABC transporter signature motif; other site 568703006393 Walker B; other site 568703006394 D-loop; other site 568703006395 ABC transporter; Region: ABC_tran_2; pfam12848 568703006396 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568703006397 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 568703006398 active site 568703006399 P-loop; other site 568703006400 phosphorylation site [posttranslational modification] 568703006401 UGMP family protein; Validated; Region: PRK09604 568703006402 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 568703006403 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 568703006404 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 568703006405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703006406 Coenzyme A binding pocket [chemical binding]; other site 568703006407 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 568703006408 Glycoprotease family; Region: Peptidase_M22; pfam00814 568703006409 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 568703006410 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 568703006411 active site 568703006412 homodimer interface [polypeptide binding]; other site 568703006413 homotetramer interface [polypeptide binding]; other site 568703006414 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 568703006415 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 568703006416 active site 568703006417 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568703006418 active site 2 [active] 568703006419 active site 1 [active] 568703006420 Predicted methyltransferases [General function prediction only]; Region: COG0313 568703006421 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 568703006422 putative SAM binding site [chemical binding]; other site 568703006423 putative homodimer interface [polypeptide binding]; other site 568703006424 Protein of unknown function (DUF972); Region: DUF972; pfam06156 568703006425 DNA polymerase III subunit delta'; Validated; Region: PRK08058 568703006426 DNA polymerase III subunit delta'; Validated; Region: PRK08485 568703006427 Protein of unknown function (DUF970); Region: DUF970; pfam06153 568703006428 thymidylate kinase; Validated; Region: tmk; PRK00698 568703006429 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 568703006430 TMP-binding site; other site 568703006431 ATP-binding site [chemical binding]; other site 568703006432 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 568703006433 recombination protein RecR; Reviewed; Region: recR; PRK00076 568703006434 RecR protein; Region: RecR; pfam02132 568703006435 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 568703006436 putative active site [active] 568703006437 putative metal-binding site [ion binding]; other site 568703006438 tetramer interface [polypeptide binding]; other site 568703006439 hypothetical protein; Validated; Region: PRK00153 568703006440 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 568703006441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703006442 Walker A motif; other site 568703006443 ATP binding site [chemical binding]; other site 568703006444 Walker B motif; other site 568703006445 arginine finger; other site 568703006446 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 568703006447 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 568703006448 nucleoside/Zn binding site; other site 568703006449 dimer interface [polypeptide binding]; other site 568703006450 catalytic motif [active] 568703006451 Methyltransferase domain; Region: Methyltransf_31; pfam13847 568703006452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703006453 S-adenosylmethionine binding site [chemical binding]; other site 568703006454 Predicted integral membrane protein [Function unknown]; Region: COG0392 568703006455 Uncharacterized conserved protein [Function unknown]; Region: COG2898 568703006456 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 568703006457 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568703006458 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568703006459 DNA binding site [nucleotide binding] 568703006460 domain linker motif; other site 568703006461 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 568703006462 putative dimerization interface [polypeptide binding]; other site 568703006463 putative ligand binding site [chemical binding]; other site 568703006464 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 568703006465 putative active site [active] 568703006466 catalytic triad [active] 568703006467 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 568703006468 putative active site [active] 568703006469 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 568703006470 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 568703006471 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 568703006472 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 568703006473 core dimer interface [polypeptide binding]; other site 568703006474 peripheral dimer interface [polypeptide binding]; other site 568703006475 L10 interface [polypeptide binding]; other site 568703006476 L11 interface [polypeptide binding]; other site 568703006477 putative EF-Tu interaction site [polypeptide binding]; other site 568703006478 putative EF-G interaction site [polypeptide binding]; other site 568703006479 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 568703006480 23S rRNA interface [nucleotide binding]; other site 568703006481 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 568703006482 drug efflux system protein MdtG; Provisional; Region: PRK09874 568703006483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006484 putative substrate translocation pore; other site 568703006485 benzoate transport; Region: 2A0115; TIGR00895 568703006486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006487 putative substrate translocation pore; other site 568703006488 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 568703006489 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 568703006490 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568703006491 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703006492 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 568703006493 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 568703006494 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703006495 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568703006496 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 568703006497 NAD(P) binding site [chemical binding]; other site 568703006498 catalytic residues [active] 568703006499 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 568703006500 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568703006501 Coenzyme A binding pocket [chemical binding]; other site 568703006502 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 568703006503 mRNA/rRNA interface [nucleotide binding]; other site 568703006504 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 568703006505 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 568703006506 23S rRNA interface [nucleotide binding]; other site 568703006507 L7/L12 interface [polypeptide binding]; other site 568703006508 putative thiostrepton binding site; other site 568703006509 L25 interface [polypeptide binding]; other site 568703006510 magnesium-transporting ATPase; Provisional; Region: PRK15122 568703006511 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 568703006512 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703006513 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 568703006514 Soluble P-type ATPase [General function prediction only]; Region: COG4087 568703006515 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568703006516 amidase; Provisional; Region: PRK06529 568703006517 Amidase; Region: Amidase; cl11426 568703006518 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 568703006519 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 568703006520 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 568703006521 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 568703006522 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 568703006523 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 568703006524 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 568703006525 putative homodimer interface [polypeptide binding]; other site 568703006526 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 568703006527 heterodimer interface [polypeptide binding]; other site 568703006528 homodimer interface [polypeptide binding]; other site 568703006529 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 568703006530 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 568703006531 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 568703006532 UbiA prenyltransferase family; Region: UbiA; pfam01040 568703006533 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 568703006534 UbiA prenyltransferase family; Region: UbiA; pfam01040 568703006535 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 568703006536 ApbE family; Region: ApbE; pfam02424 568703006537 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 568703006538 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 568703006539 Probable transposase; Region: OrfB_IS605; pfam01385 568703006540 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 568703006541 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 568703006542 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 568703006543 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 568703006544 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568703006545 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703006546 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 568703006547 trimer interface [polypeptide binding]; other site 568703006548 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 568703006549 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 568703006550 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 568703006551 substrate binding pocket [chemical binding]; other site 568703006552 chain length determination region; other site 568703006553 substrate-Mg2+ binding site; other site 568703006554 catalytic residues [active] 568703006555 aspartate-rich region 1; other site 568703006556 active site lid residues [active] 568703006557 aspartate-rich region 2; other site 568703006558 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568703006559 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 568703006560 active site 568703006561 metal binding site [ion binding]; metal-binding site 568703006562 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 568703006563 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568703006564 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703006565 Walker A/P-loop; other site 568703006566 ATP binding site [chemical binding]; other site 568703006567 Q-loop/lid; other site 568703006568 ABC transporter signature motif; other site 568703006569 Walker B; other site 568703006570 D-loop; other site 568703006571 H-loop/switch region; other site 568703006572 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 568703006573 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 568703006574 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 568703006575 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 568703006576 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 568703006577 YacP-like NYN domain; Region: NYN_YacP; pfam05991 568703006578 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 568703006579 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 568703006580 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 568703006581 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 568703006582 active site 568703006583 metal binding site [ion binding]; metal-binding site 568703006584 dimerization interface [polypeptide binding]; other site 568703006585 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 568703006586 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 568703006587 active site 568703006588 HIGH motif; other site 568703006589 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 568703006590 KMSKS motif; other site 568703006591 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 568703006592 tRNA binding surface [nucleotide binding]; other site 568703006593 anticodon binding site; other site 568703006594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703006595 non-specific DNA binding site [nucleotide binding]; other site 568703006596 salt bridge; other site 568703006597 sequence-specific DNA binding site [nucleotide binding]; other site 568703006598 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 568703006599 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 568703006600 FAD binding domain; Region: FAD_binding_4; pfam01565 568703006601 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 568703006602 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 568703006603 active site 568703006604 HIGH motif; other site 568703006605 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 568703006606 active site 568703006607 KMSKS motif; other site 568703006608 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 568703006609 Predicted membrane protein [General function prediction only]; Region: COG4194 568703006610 Predicted transcriptional regulators [Transcription]; Region: COG1725 568703006611 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703006612 DNA-binding site [nucleotide binding]; DNA binding site 568703006613 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703006614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703006615 Walker A/P-loop; other site 568703006616 ATP binding site [chemical binding]; other site 568703006617 ABC transporter; Region: ABC_tran; pfam00005 568703006618 Q-loop/lid; other site 568703006619 ABC transporter signature motif; other site 568703006620 Walker B; other site 568703006621 D-loop; other site 568703006622 H-loop/switch region; other site 568703006623 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 568703006624 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 568703006625 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 568703006626 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 568703006627 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 568703006628 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 568703006629 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 568703006630 putative active site [active] 568703006631 DNA repair protein RadA; Provisional; Region: PRK11823 568703006632 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 568703006633 Walker A motif/ATP binding site; other site 568703006634 ATP binding site [chemical binding]; other site 568703006635 Walker B motif; other site 568703006636 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 568703006637 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 568703006638 trimer interface [polypeptide binding]; other site 568703006639 active site 568703006640 Predicted acetyltransferase [General function prediction only]; Region: COG2388 568703006641 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 568703006642 trimer interface [polypeptide binding]; other site 568703006643 active site 568703006644 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 568703006645 trimer interface [polypeptide binding]; other site 568703006646 active site 568703006647 G bulge; other site 568703006648 Domain of unknown function (DUF373); Region: DUF373; cl12079 568703006649 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 568703006650 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703006651 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703006652 Walker A/P-loop; other site 568703006653 ATP binding site [chemical binding]; other site 568703006654 Q-loop/lid; other site 568703006655 ABC transporter signature motif; other site 568703006656 Walker B; other site 568703006657 D-loop; other site 568703006658 H-loop/switch region; other site 568703006659 K+ potassium transporter; Region: K_trans; pfam02705 568703006660 pyruvate phosphate dikinase; Provisional; Region: PRK09279 568703006661 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 568703006662 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 568703006663 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 568703006664 HTH domain; Region: HTH_11; pfam08279 568703006665 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 568703006666 FOG: CBS domain [General function prediction only]; Region: COG0517 568703006667 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703006668 catalytic core [active] 568703006669 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703006670 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 568703006671 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 568703006672 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 568703006673 teramer interface [polypeptide binding]; other site 568703006674 active site 568703006675 FMN binding site [chemical binding]; other site 568703006676 catalytic residues [active] 568703006677 CsbD-like; Region: CsbD; pfam05532 568703006678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006679 H+ Antiporter protein; Region: 2A0121; TIGR00900 568703006680 putative substrate translocation pore; other site 568703006681 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 568703006682 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 568703006683 putative catalytic cysteine [active] 568703006684 gamma-glutamyl kinase; Provisional; Region: PRK05429 568703006685 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 568703006686 nucleotide binding site [chemical binding]; other site 568703006687 homotetrameric interface [polypeptide binding]; other site 568703006688 putative phosphate binding site [ion binding]; other site 568703006689 putative allosteric binding site; other site 568703006690 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 568703006691 active site 568703006692 catalytic site [active] 568703006693 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 568703006694 Cna protein B-type domain; Region: Cna_B; pfam05738 568703006695 Cna protein B-type domain; Region: Cna_B; pfam05738 568703006696 Cna protein B-type domain; Region: Cna_B; pfam05738 568703006697 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 568703006698 Uncharacterized conserved protein [Function unknown]; Region: COG3410 568703006699 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 568703006700 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703006701 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703006702 non-specific DNA binding site [nucleotide binding]; other site 568703006703 salt bridge; other site 568703006704 sequence-specific DNA binding site [nucleotide binding]; other site 568703006705 Predicted transcriptional regulators [Transcription]; Region: COG1695 568703006706 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 568703006707 hypothetical protein; Validated; Region: PRK07668 568703006708 Enterocin A Immunity; Region: EntA_Immun; pfam08951 568703006709 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703006710 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703006711 active site 568703006712 catalytic tetrad [active] 568703006713 Uncharacterized conserved protein [Function unknown]; Region: COG2966 568703006714 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 568703006715 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 568703006716 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 568703006717 HlyD family secretion protein; Region: HlyD_3; pfam13437 568703006718 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 568703006719 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 568703006720 putative active site [active] 568703006721 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703006722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703006723 Walker A/P-loop; other site 568703006724 ATP binding site [chemical binding]; other site 568703006725 Q-loop/lid; other site 568703006726 ABC transporter signature motif; other site 568703006727 Walker B; other site 568703006728 D-loop; other site 568703006729 H-loop/switch region; other site 568703006730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703006731 ATP binding site [chemical binding]; other site 568703006732 Mg2+ binding site [ion binding]; other site 568703006733 G-X-G motif; other site 568703006734 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 568703006735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 568703006736 phosphorylation site [posttranslational modification] 568703006737 intermolecular recognition site; other site 568703006738 LytTr DNA-binding domain; Region: LytTR; pfam04397 568703006739 CAAX protease self-immunity; Region: Abi; pfam02517 568703006740 Rrf2 family protein; Region: rrf2_super; TIGR00738 568703006741 Transcriptional regulator; Region: Rrf2; pfam02082 568703006742 Transcriptional regulator; Region: Rrf2; cl17282 568703006743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006744 putative substrate translocation pore; other site 568703006745 Enterocin A Immunity; Region: EntA_Immun; pfam08951 568703006746 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703006747 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703006748 active site 568703006749 catalytic tetrad [active] 568703006750 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 568703006751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703006752 NAD(P) binding site [chemical binding]; other site 568703006753 active site 568703006754 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 568703006755 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 568703006756 putative active site [active] 568703006757 putative FMN binding site [chemical binding]; other site 568703006758 putative substrate binding site [chemical binding]; other site 568703006759 putative catalytic residue [active] 568703006760 Short C-terminal domain; Region: SHOCT; pfam09851 568703006761 fumarate hydratase; Reviewed; Region: fumC; PRK00485 568703006762 Class II fumarases; Region: Fumarase_classII; cd01362 568703006763 active site 568703006764 tetramer interface [polypeptide binding]; other site 568703006765 manganese transport protein MntH; Reviewed; Region: PRK00701 568703006766 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 568703006767 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 568703006768 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 568703006769 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703006770 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 568703006771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703006772 motif II; other site 568703006773 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568703006774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006775 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568703006776 putative substrate translocation pore; other site 568703006777 multicopper oxidase; Provisional; Region: PRK10965 568703006778 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 568703006779 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 568703006780 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 568703006781 Cation efflux family; Region: Cation_efflux; cl00316 568703006782 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568703006783 dimerization interface [polypeptide binding]; other site 568703006784 putative DNA binding site [nucleotide binding]; other site 568703006785 putative Zn2+ binding site [ion binding]; other site 568703006786 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 568703006787 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 568703006788 metal binding site [ion binding]; metal-binding site 568703006789 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 568703006790 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 568703006791 ABC-ATPase subunit interface; other site 568703006792 dimer interface [polypeptide binding]; other site 568703006793 putative PBP binding regions; other site 568703006794 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 568703006795 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 568703006796 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 568703006797 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 568703006798 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 568703006799 intersubunit interface [polypeptide binding]; other site 568703006800 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 568703006801 NADH(P)-binding; Region: NAD_binding_10; pfam13460 568703006802 putative NAD(P) binding site [chemical binding]; other site 568703006803 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 568703006804 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 568703006805 metal binding site [ion binding]; metal-binding site 568703006806 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 568703006807 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 568703006808 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 568703006809 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 568703006810 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 568703006811 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 568703006812 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703006813 substrate binding pocket [chemical binding]; other site 568703006814 membrane-bound complex binding site; other site 568703006815 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 568703006816 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568703006817 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 568703006818 acyl-activating enzyme (AAE) consensus motif; other site 568703006819 acyl-activating enzyme (AAE) consensus motif; other site 568703006820 putative AMP binding site [chemical binding]; other site 568703006821 putative active site [active] 568703006822 putative CoA binding site [chemical binding]; other site 568703006823 Acyltransferase family; Region: Acyl_transf_3; pfam01757 568703006824 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703006825 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 568703006826 Walker A/P-loop; other site 568703006827 ATP binding site [chemical binding]; other site 568703006828 Q-loop/lid; other site 568703006829 ABC transporter signature motif; other site 568703006830 Walker B; other site 568703006831 D-loop; other site 568703006832 H-loop/switch region; other site 568703006833 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568703006834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703006835 putative PBP binding loops; other site 568703006836 dimer interface [polypeptide binding]; other site 568703006837 ABC-ATPase subunit interface; other site 568703006838 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 568703006839 B3/4 domain; Region: B3_4; pfam03483 568703006840 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703006841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703006842 Walker A/P-loop; other site 568703006843 ATP binding site [chemical binding]; other site 568703006844 Q-loop/lid; other site 568703006845 ABC transporter signature motif; other site 568703006846 Walker B; other site 568703006847 D-loop; other site 568703006848 H-loop/switch region; other site 568703006849 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703006850 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703006851 Walker A/P-loop; other site 568703006852 ATP binding site [chemical binding]; other site 568703006853 Q-loop/lid; other site 568703006854 ABC transporter signature motif; other site 568703006855 Walker B; other site 568703006856 D-loop; other site 568703006857 H-loop/switch region; other site 568703006858 H+ Antiporter protein; Region: 2A0121; TIGR00900 568703006859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006860 putative substrate translocation pore; other site 568703006861 putative transposase OrfB; Reviewed; Region: PHA02517 568703006862 HTH-like domain; Region: HTH_21; pfam13276 568703006863 Integrase core domain; Region: rve; pfam00665 568703006864 Integrase core domain; Region: rve_2; pfam13333 568703006865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568703006866 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703006867 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 568703006868 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703006869 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 568703006870 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 568703006871 23S rRNA interface [nucleotide binding]; other site 568703006872 L3 interface [polypeptide binding]; other site 568703006873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703006874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703006875 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 568703006876 FtsX-like permease family; Region: FtsX; pfam02687 568703006877 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703006878 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568703006879 Walker A/P-loop; other site 568703006880 ATP binding site [chemical binding]; other site 568703006881 Q-loop/lid; other site 568703006882 ABC transporter signature motif; other site 568703006883 Walker B; other site 568703006884 D-loop; other site 568703006885 H-loop/switch region; other site 568703006886 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 568703006887 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 568703006888 DNA binding residues [nucleotide binding] 568703006889 dimer interface [polypeptide binding]; other site 568703006890 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 568703006891 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 568703006892 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 568703006893 dimerization interface 3.5A [polypeptide binding]; other site 568703006894 active site 568703006895 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 568703006896 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 568703006897 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 568703006898 Walker A/P-loop; other site 568703006899 ATP binding site [chemical binding]; other site 568703006900 Q-loop/lid; other site 568703006901 ABC transporter signature motif; other site 568703006902 Walker B; other site 568703006903 D-loop; other site 568703006904 H-loop/switch region; other site 568703006905 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 568703006906 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 568703006907 Walker A/P-loop; other site 568703006908 ATP binding site [chemical binding]; other site 568703006909 Q-loop/lid; other site 568703006910 ABC transporter signature motif; other site 568703006911 Walker B; other site 568703006912 D-loop; other site 568703006913 H-loop/switch region; other site 568703006914 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 568703006915 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 568703006916 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 568703006917 alphaNTD homodimer interface [polypeptide binding]; other site 568703006918 alphaNTD - beta interaction site [polypeptide binding]; other site 568703006919 alphaNTD - beta' interaction site [polypeptide binding]; other site 568703006920 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 568703006921 30S ribosomal protein S11; Validated; Region: PRK05309 568703006922 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 568703006923 30S ribosomal protein S13; Region: bact_S13; TIGR03631 568703006924 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 568703006925 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 568703006926 rRNA binding site [nucleotide binding]; other site 568703006927 predicted 30S ribosome binding site; other site 568703006928 adenylate kinase; Reviewed; Region: adk; PRK00279 568703006929 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 568703006930 AMP-binding site [chemical binding]; other site 568703006931 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 568703006932 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 568703006933 SecY translocase; Region: SecY; pfam00344 568703006934 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 568703006935 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 568703006936 23S rRNA binding site [nucleotide binding]; other site 568703006937 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 568703006938 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 568703006939 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 568703006940 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 568703006941 5S rRNA interface [nucleotide binding]; other site 568703006942 L27 interface [polypeptide binding]; other site 568703006943 23S rRNA interface [nucleotide binding]; other site 568703006944 L5 interface [polypeptide binding]; other site 568703006945 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 568703006946 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 568703006947 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 568703006948 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 568703006949 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 568703006950 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 568703006951 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 568703006952 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 568703006953 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 568703006954 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 568703006955 RNA binding site [nucleotide binding]; other site 568703006956 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 568703006957 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 568703006958 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 568703006959 23S rRNA interface [nucleotide binding]; other site 568703006960 putative translocon interaction site; other site 568703006961 signal recognition particle (SRP54) interaction site; other site 568703006962 L23 interface [polypeptide binding]; other site 568703006963 trigger factor interaction site; other site 568703006964 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 568703006965 23S rRNA interface [nucleotide binding]; other site 568703006966 5S rRNA interface [nucleotide binding]; other site 568703006967 putative antibiotic binding site [chemical binding]; other site 568703006968 L25 interface [polypeptide binding]; other site 568703006969 L27 interface [polypeptide binding]; other site 568703006970 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 568703006971 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 568703006972 G-X-X-G motif; other site 568703006973 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 568703006974 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 568703006975 putative translocon binding site; other site 568703006976 protein-rRNA interface [nucleotide binding]; other site 568703006977 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 568703006978 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 568703006979 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 568703006980 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 568703006981 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 568703006982 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 568703006983 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 568703006984 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 568703006985 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 568703006986 peroxiredoxin; Region: AhpC; TIGR03137 568703006987 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 568703006988 dimer interface [polypeptide binding]; other site 568703006989 decamer (pentamer of dimers) interface [polypeptide binding]; other site 568703006990 catalytic triad [active] 568703006991 peroxidatic and resolving cysteines [active] 568703006992 Predicted transcriptional regulator [Transcription]; Region: COG2378 568703006993 WYL domain; Region: WYL; pfam13280 568703006994 elongation factor G; Reviewed; Region: PRK12739 568703006995 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 568703006996 G1 box; other site 568703006997 putative GEF interaction site [polypeptide binding]; other site 568703006998 GTP/Mg2+ binding site [chemical binding]; other site 568703006999 Switch I region; other site 568703007000 G2 box; other site 568703007001 G3 box; other site 568703007002 Switch II region; other site 568703007003 G4 box; other site 568703007004 G5 box; other site 568703007005 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 568703007006 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 568703007007 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 568703007008 30S ribosomal protein S7; Validated; Region: PRK05302 568703007009 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 568703007010 S17 interaction site [polypeptide binding]; other site 568703007011 S8 interaction site; other site 568703007012 16S rRNA interaction site [nucleotide binding]; other site 568703007013 streptomycin interaction site [chemical binding]; other site 568703007014 23S rRNA interaction site [nucleotide binding]; other site 568703007015 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 568703007016 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 568703007017 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 568703007018 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 568703007019 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 568703007020 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 568703007021 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 568703007022 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 568703007023 DNA binding site [nucleotide binding] 568703007024 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 568703007025 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 568703007026 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 568703007027 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 568703007028 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 568703007029 RPB1 interaction site [polypeptide binding]; other site 568703007030 RPB10 interaction site [polypeptide binding]; other site 568703007031 RPB11 interaction site [polypeptide binding]; other site 568703007032 RPB3 interaction site [polypeptide binding]; other site 568703007033 RPB12 interaction site [polypeptide binding]; other site 568703007034 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 568703007035 Clp amino terminal domain; Region: Clp_N; pfam02861 568703007036 Clp amino terminal domain; Region: Clp_N; pfam02861 568703007037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703007038 Walker A motif; other site 568703007039 ATP binding site [chemical binding]; other site 568703007040 Walker B motif; other site 568703007041 arginine finger; other site 568703007042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703007043 Walker A motif; other site 568703007044 ATP binding site [chemical binding]; other site 568703007045 Walker B motif; other site 568703007046 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 568703007047 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 568703007048 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 568703007049 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 568703007050 dimer interface [polypeptide binding]; other site 568703007051 putative anticodon binding site; other site 568703007052 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 568703007053 motif 1; other site 568703007054 active site 568703007055 motif 2; other site 568703007056 motif 3; other site 568703007057 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 568703007058 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 568703007059 FMN binding site [chemical binding]; other site 568703007060 active site 568703007061 catalytic residues [active] 568703007062 substrate binding site [chemical binding]; other site 568703007063 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 568703007064 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 568703007065 dimerization interface [polypeptide binding]; other site 568703007066 domain crossover interface; other site 568703007067 redox-dependent activation switch; other site 568703007068 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 568703007069 FtsH Extracellular; Region: FtsH_ext; pfam06480 568703007070 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 568703007071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703007072 Walker A motif; other site 568703007073 ATP binding site [chemical binding]; other site 568703007074 Walker B motif; other site 568703007075 arginine finger; other site 568703007076 Peptidase family M41; Region: Peptidase_M41; pfam01434 568703007077 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 568703007078 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703007079 active site 568703007080 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 568703007081 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 568703007082 Ligand Binding Site [chemical binding]; other site 568703007083 TilS substrate C-terminal domain; Region: TilS_C; smart00977 568703007084 hypothetical protein; Provisional; Region: PRK08582 568703007085 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 568703007086 RNA binding site [nucleotide binding]; other site 568703007087 Septum formation initiator; Region: DivIC; pfam04977 568703007088 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703007089 RNA binding surface [nucleotide binding]; other site 568703007090 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 568703007091 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 568703007092 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 568703007093 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 568703007094 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703007095 ATP binding site [chemical binding]; other site 568703007096 putative Mg++ binding site [ion binding]; other site 568703007097 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703007098 nucleotide binding region [chemical binding]; other site 568703007099 ATP-binding site [chemical binding]; other site 568703007100 TRCF domain; Region: TRCF; pfam03461 568703007101 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 568703007102 putative active site [active] 568703007103 catalytic residue [active] 568703007104 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 568703007105 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 568703007106 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703007107 NAD binding site [chemical binding]; other site 568703007108 dimer interface [polypeptide binding]; other site 568703007109 substrate binding site [chemical binding]; other site 568703007110 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 568703007111 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 568703007112 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568703007113 Predicted transcriptional regulators [Transcription]; Region: COG1695 568703007114 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 568703007115 Predicted membrane protein [Function unknown]; Region: COG1511 568703007116 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 568703007117 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 568703007118 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 568703007119 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 568703007120 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 568703007121 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568703007122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 568703007123 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 568703007124 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568703007125 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 568703007126 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 568703007127 active site 568703007128 dimer interface [polypeptide binding]; other site 568703007129 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 568703007130 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 568703007131 active site 568703007132 FMN binding site [chemical binding]; other site 568703007133 substrate binding site [chemical binding]; other site 568703007134 3Fe-4S cluster binding site [ion binding]; other site 568703007135 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 568703007136 domain interface; other site 568703007137 QueT transporter; Region: QueT; pfam06177 568703007138 PemK-like protein; Region: PemK; pfam02452 568703007139 hypothetical protein; Region: PHA01623 568703007140 alanine racemase; Reviewed; Region: alr; PRK00053 568703007141 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 568703007142 active site 568703007143 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568703007144 dimer interface [polypeptide binding]; other site 568703007145 substrate binding site [chemical binding]; other site 568703007146 catalytic residues [active] 568703007147 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 568703007148 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 568703007149 DEAD-like helicases superfamily; Region: DEXDc; smart00487 568703007150 ATP binding site [chemical binding]; other site 568703007151 Mg++ binding site [ion binding]; other site 568703007152 motif III; other site 568703007153 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703007154 nucleotide binding region [chemical binding]; other site 568703007155 ATP-binding site [chemical binding]; other site 568703007156 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 568703007157 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568703007158 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568703007159 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568703007160 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 568703007161 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 568703007162 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 568703007163 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 568703007164 hinge; other site 568703007165 active site 568703007166 CTP synthetase; Validated; Region: pyrG; PRK05380 568703007167 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 568703007168 Catalytic site [active] 568703007169 active site 568703007170 UTP binding site [chemical binding]; other site 568703007171 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 568703007172 active site 568703007173 putative oxyanion hole; other site 568703007174 catalytic triad [active] 568703007175 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 568703007176 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703007177 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 568703007178 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 568703007179 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 568703007180 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 568703007181 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 568703007182 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568703007183 Zn2+ binding site [ion binding]; other site 568703007184 Mg2+ binding site [ion binding]; other site 568703007185 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 568703007186 nudix motif; other site 568703007187 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 568703007188 Uncharacterized conserved protein [Function unknown]; Region: COG1434 568703007189 putative active site [active] 568703007190 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 568703007191 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 568703007192 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 568703007193 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 568703007194 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 568703007195 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703007196 active site 568703007197 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 568703007198 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 568703007199 Substrate binding site; other site 568703007200 Mg++ binding site; other site 568703007201 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 568703007202 active site 568703007203 substrate binding site [chemical binding]; other site 568703007204 CoA binding site [chemical binding]; other site 568703007205 VanZ like family; Region: VanZ; pfam04892 568703007206 RDD family; Region: RDD; pfam06271 568703007207 pur operon repressor; Provisional; Region: PRK09213 568703007208 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 568703007209 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703007210 active site 568703007211 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 568703007212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703007213 Walker A/P-loop; other site 568703007214 ATP binding site [chemical binding]; other site 568703007215 Q-loop/lid; other site 568703007216 ABC transporter signature motif; other site 568703007217 Walker B; other site 568703007218 D-loop; other site 568703007219 H-loop/switch region; other site 568703007220 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 568703007221 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 568703007222 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 568703007223 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 568703007224 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 568703007225 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 568703007226 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 568703007227 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 568703007228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703007229 S-adenosylmethionine binding site [chemical binding]; other site 568703007230 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 568703007231 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 568703007232 putative active site [active] 568703007233 putative metal binding site [ion binding]; other site 568703007234 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 568703007235 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 568703007236 active site 568703007237 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 568703007238 active site 568703007239 phosphorylation site [posttranslational modification] 568703007240 Class I aldolases; Region: Aldolase_Class_I; cl17187 568703007241 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 568703007242 active site 568703007243 catalytic residues [active] 568703007244 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 568703007245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703007246 active site 568703007247 phosphorylation site [posttranslational modification] 568703007248 intermolecular recognition site; other site 568703007249 dimerization interface [polypeptide binding]; other site 568703007250 LytTr DNA-binding domain; Region: LytTR; pfam04397 568703007251 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 568703007252 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 568703007253 ATP binding site [chemical binding]; other site 568703007254 Mg2+ binding site [ion binding]; other site 568703007255 G-X-G motif; other site 568703007256 Transmembrane protein 231; Region: TM231; pfam10149 568703007257 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568703007258 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568703007259 Walker A/P-loop; other site 568703007260 ATP binding site [chemical binding]; other site 568703007261 Q-loop/lid; other site 568703007262 ABC transporter signature motif; other site 568703007263 Walker B; other site 568703007264 D-loop; other site 568703007265 H-loop/switch region; other site 568703007266 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703007267 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703007268 Walker A/P-loop; other site 568703007269 ATP binding site [chemical binding]; other site 568703007270 Q-loop/lid; other site 568703007271 ABC transporter signature motif; other site 568703007272 Walker B; other site 568703007273 D-loop; other site 568703007274 H-loop/switch region; other site 568703007275 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703007276 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703007277 non-specific DNA binding site [nucleotide binding]; other site 568703007278 salt bridge; other site 568703007279 sequence-specific DNA binding site [nucleotide binding]; other site 568703007280 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 568703007281 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 568703007282 active site 568703007283 HIGH motif; other site 568703007284 KMSKS motif; other site 568703007285 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 568703007286 tRNA binding surface [nucleotide binding]; other site 568703007287 anticodon binding site; other site 568703007288 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 568703007289 dimer interface [polypeptide binding]; other site 568703007290 putative tRNA-binding site [nucleotide binding]; other site 568703007291 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 568703007292 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568703007293 Protein of unknown function DUF72; Region: DUF72; pfam01904 568703007294 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 568703007295 putative active site [active] 568703007296 nucleotide binding site [chemical binding]; other site 568703007297 nudix motif; other site 568703007298 putative metal binding site [ion binding]; other site 568703007299 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 568703007300 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 568703007301 LDH/MDH dimer interface [polypeptide binding]; other site 568703007302 NAD(P) binding site [chemical binding]; other site 568703007303 substrate binding site [chemical binding]; other site 568703007304 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 568703007305 NAD-dependent deacetylase; Provisional; Region: PRK00481 568703007306 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 568703007307 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 568703007308 substrate binding site [chemical binding]; other site 568703007309 Predicted secreted protein [Function unknown]; Region: COG4086 568703007310 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 568703007311 exopolyphosphatase; Region: exo_poly_only; TIGR03706 568703007312 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 568703007313 polyphosphate kinase; Provisional; Region: PRK05443 568703007314 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 568703007315 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 568703007316 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 568703007317 putative domain interface [polypeptide binding]; other site 568703007318 putative active site [active] 568703007319 catalytic site [active] 568703007320 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 568703007321 putative domain interface [polypeptide binding]; other site 568703007322 putative active site [active] 568703007323 catalytic site [active] 568703007324 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 568703007325 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703007326 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703007327 active site 568703007328 catalytic tetrad [active] 568703007329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 568703007330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568703007331 S-adenosylmethionine binding site [chemical binding]; other site 568703007332 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568703007333 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 568703007334 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 568703007335 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 568703007336 Repair protein; Region: Repair_PSII; pfam04536 568703007337 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 568703007338 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 568703007339 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 568703007340 active site 568703007341 HIGH motif; other site 568703007342 dimer interface [polypeptide binding]; other site 568703007343 KMSKS motif; other site 568703007344 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 568703007345 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568703007346 Walker A/P-loop; other site 568703007347 ATP binding site [chemical binding]; other site 568703007348 Q-loop/lid; other site 568703007349 ABC transporter signature motif; other site 568703007350 Walker B; other site 568703007351 D-loop; other site 568703007352 H-loop/switch region; other site 568703007353 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 568703007354 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568703007355 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568703007356 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 568703007357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703007358 Walker A/P-loop; other site 568703007359 ATP binding site [chemical binding]; other site 568703007360 Q-loop/lid; other site 568703007361 ABC transporter signature motif; other site 568703007362 Walker B; other site 568703007363 D-loop; other site 568703007364 H-loop/switch region; other site 568703007365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703007366 dimer interface [polypeptide binding]; other site 568703007367 conserved gate region; other site 568703007368 ABC-ATPase subunit interface; other site 568703007369 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 568703007370 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 568703007371 Part of AAA domain; Region: AAA_19; pfam13245 568703007372 Family description; Region: UvrD_C_2; pfam13538 568703007373 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703007374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703007375 LysR substrate binding domain; Region: LysR_substrate; pfam03466 568703007376 dimerization interface [polypeptide binding]; other site 568703007377 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 568703007378 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 568703007379 gating phenylalanine in ion channel; other site 568703007380 ABC-2 type transporter; Region: ABC2_membrane; cl17235 568703007381 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 568703007382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703007383 Walker A/P-loop; other site 568703007384 ATP binding site [chemical binding]; other site 568703007385 Q-loop/lid; other site 568703007386 ABC transporter signature motif; other site 568703007387 Walker B; other site 568703007388 D-loop; other site 568703007389 H-loop/switch region; other site 568703007390 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568703007391 putative DNA binding site [nucleotide binding]; other site 568703007392 dimerization interface [polypeptide binding]; other site 568703007393 putative Zn2+ binding site [ion binding]; other site 568703007394 CAAX protease self-immunity; Region: Abi; pfam02517 568703007395 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568703007396 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703007397 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568703007398 Walker A/P-loop; other site 568703007399 ATP binding site [chemical binding]; other site 568703007400 Q-loop/lid; other site 568703007401 ABC transporter signature motif; other site 568703007402 Walker B; other site 568703007403 D-loop; other site 568703007404 H-loop/switch region; other site 568703007405 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 568703007406 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 568703007407 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568703007408 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 568703007409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703007410 Walker A/P-loop; other site 568703007411 ATP binding site [chemical binding]; other site 568703007412 Q-loop/lid; other site 568703007413 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 568703007414 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 568703007415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703007416 ABC transporter signature motif; other site 568703007417 Walker B; other site 568703007418 D-loop; other site 568703007419 H-loop/switch region; other site 568703007420 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703007421 Walker A/P-loop; other site 568703007422 ATP binding site [chemical binding]; other site 568703007423 Q-loop/lid; other site 568703007424 ABC transporter signature motif; other site 568703007425 Walker B; other site 568703007426 D-loop; other site 568703007427 H-loop/switch region; other site 568703007428 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703007429 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703007430 active site 568703007431 catalytic tetrad [active] 568703007432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 568703007433 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703007434 active site 568703007435 motif I; other site 568703007436 motif II; other site 568703007437 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703007438 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 568703007439 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703007440 catalytic core [active] 568703007441 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 568703007442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703007443 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703007444 active site 568703007445 motif I; other site 568703007446 motif II; other site 568703007447 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703007448 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 568703007449 RNA/DNA hybrid binding site [nucleotide binding]; other site 568703007450 active site 568703007451 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703007452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703007453 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703007454 dimerization interface [polypeptide binding]; other site 568703007455 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 568703007456 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703007457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703007458 homodimer interface [polypeptide binding]; other site 568703007459 catalytic residue [active] 568703007460 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 568703007461 recombinase A; Provisional; Region: recA; PRK09354 568703007462 hexamer interface [polypeptide binding]; other site 568703007463 Walker A motif; other site 568703007464 ATP binding site [chemical binding]; other site 568703007465 Walker B motif; other site 568703007466 Protein of unknown function (DUF554); Region: DUF554; pfam04474 568703007467 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 568703007468 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 568703007469 active site 568703007470 P-loop; other site 568703007471 phosphorylation site [posttranslational modification] 568703007472 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 568703007473 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703007474 active site 568703007475 phosphorylation site [posttranslational modification] 568703007476 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 568703007477 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 568703007478 putative substrate binding site [chemical binding]; other site 568703007479 putative ATP binding site [chemical binding]; other site 568703007480 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568703007481 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568703007482 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568703007483 putative active site [active] 568703007484 glycerol kinase; Provisional; Region: glpK; PRK00047 568703007485 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 568703007486 N- and C-terminal domain interface [polypeptide binding]; other site 568703007487 active site 568703007488 MgATP binding site [chemical binding]; other site 568703007489 catalytic site [active] 568703007490 metal binding site [ion binding]; metal-binding site 568703007491 glycerol binding site [chemical binding]; other site 568703007492 homotetramer interface [polypeptide binding]; other site 568703007493 homodimer interface [polypeptide binding]; other site 568703007494 FBP binding site [chemical binding]; other site 568703007495 protein IIAGlc interface [polypeptide binding]; other site 568703007496 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703007497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703007498 DNA-binding site [nucleotide binding]; DNA binding site 568703007499 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 568703007500 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 568703007501 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 568703007502 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 568703007503 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 568703007504 active site 568703007505 active pocket/dimerization site; other site 568703007506 phosphorylation site [posttranslational modification] 568703007507 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 568703007508 active site 568703007509 phosphorylation site [posttranslational modification] 568703007510 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 568703007511 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 568703007512 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 568703007513 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 568703007514 Flavoprotein; Region: Flavoprotein; pfam02441 568703007515 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 568703007516 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 568703007517 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703007518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568703007519 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703007520 dimerization interface [polypeptide binding]; other site 568703007521 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568703007522 MarR family; Region: MarR_2; pfam12802 568703007523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703007524 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703007525 putative substrate translocation pore; other site 568703007526 galactonate dehydratase; Provisional; Region: PRK14017 568703007527 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 568703007528 metal binding site [ion binding]; metal-binding site 568703007529 substrate binding pocket [chemical binding]; other site 568703007530 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 568703007531 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568703007532 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 568703007533 active site 568703007534 P-loop; other site 568703007535 phosphorylation site [posttranslational modification] 568703007536 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703007537 active site 568703007538 phosphorylation site [posttranslational modification] 568703007539 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 568703007540 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 568703007541 active site 568703007542 intersubunit interface [polypeptide binding]; other site 568703007543 catalytic residue [active] 568703007544 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 568703007545 PRD domain; Region: PRD; pfam00874 568703007546 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 568703007547 active site 568703007548 P-loop; other site 568703007549 phosphorylation site [posttranslational modification] 568703007550 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703007551 active site 568703007552 phosphorylation site [posttranslational modification] 568703007553 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 568703007554 active site 568703007555 methionine cluster; other site 568703007556 phosphorylation site [posttranslational modification] 568703007557 metal binding site [ion binding]; metal-binding site 568703007558 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 568703007559 active site 568703007560 P-loop; other site 568703007561 phosphorylation site [posttranslational modification] 568703007562 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 568703007563 beta-galactosidase; Region: BGL; TIGR03356 568703007564 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568703007565 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 568703007566 nucleotide binding site [chemical binding]; other site 568703007567 Uncharacterized conserved protein [Function unknown]; Region: COG3538 568703007568 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 568703007569 alpha-mannosidase; Provisional; Region: PRK09819 568703007570 Transposase domain (DUF772); Region: DUF772; pfam05598 568703007571 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703007572 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 568703007573 active site 568703007574 metal binding site [ion binding]; metal-binding site 568703007575 catalytic site [active] 568703007576 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 568703007577 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 568703007578 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 568703007579 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703007580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703007581 DNA-binding site [nucleotide binding]; DNA binding site 568703007582 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 568703007583 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703007584 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 568703007585 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568703007586 hypothetical protein; Provisional; Region: PRK06357 568703007587 active site 568703007588 intersubunit interface [polypeptide binding]; other site 568703007589 Zn2+ binding site [ion binding]; other site 568703007590 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 568703007591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703007592 putative substrate translocation pore; other site 568703007593 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 568703007594 Phage protein; Region: DUF3647; cl10335 568703007595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703007596 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 568703007597 N- and C-terminal domain interface [polypeptide binding]; other site 568703007598 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 568703007599 active site 568703007600 putative catalytic site [active] 568703007601 metal binding site [ion binding]; metal-binding site 568703007602 ATP binding site [chemical binding]; other site 568703007603 carbohydrate binding site [chemical binding]; other site 568703007604 L-fucose isomerase; Provisional; Region: fucI; PRK10991 568703007605 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 568703007606 hexamer (dimer of trimers) interface [polypeptide binding]; other site 568703007607 trimer interface [polypeptide binding]; other site 568703007608 substrate binding site [chemical binding]; other site 568703007609 Mn binding site [ion binding]; other site 568703007610 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 568703007611 intersubunit interface [polypeptide binding]; other site 568703007612 active site 568703007613 Zn2+ binding site [ion binding]; other site 568703007614 L-rhamnose isomerase; Provisional; Region: PRK01076 568703007615 Domain of unknown function (DUF718); Region: DUF718; cl01281 568703007616 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 568703007617 N- and C-terminal domain interface [polypeptide binding]; other site 568703007618 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 568703007619 active site 568703007620 putative catalytic site [active] 568703007621 metal binding site [ion binding]; metal-binding site 568703007622 ATP binding site [chemical binding]; other site 568703007623 carbohydrate binding site [chemical binding]; other site 568703007624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703007625 putative substrate translocation pore; other site 568703007626 Cupin domain; Region: Cupin_2; pfam07883 568703007627 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568703007628 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 568703007629 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 568703007630 catalytic Zn binding site [ion binding]; other site 568703007631 NAD binding site [chemical binding]; other site 568703007632 structural Zn binding site [ion binding]; other site 568703007633 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 568703007634 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 568703007635 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 568703007636 Ca binding site [ion binding]; other site 568703007637 active site 568703007638 catalytic site [active] 568703007639 putative transposase OrfB; Reviewed; Region: PHA02517 568703007640 HTH-like domain; Region: HTH_21; pfam13276 568703007641 Integrase core domain; Region: rve; pfam00665 568703007642 Integrase core domain; Region: rve_2; pfam13333 568703007643 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568703007644 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703007645 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 568703007646 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703007647 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 568703007648 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703007649 active site 568703007650 dimer interface [polypeptide binding]; other site 568703007651 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 568703007652 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 568703007653 NAD binding site [chemical binding]; other site 568703007654 sugar binding site [chemical binding]; other site 568703007655 divalent metal binding site [ion binding]; other site 568703007656 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703007657 dimer interface [polypeptide binding]; other site 568703007658 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 568703007659 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 568703007660 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 568703007661 active site turn [active] 568703007662 phosphorylation site [posttranslational modification] 568703007663 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568703007664 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568703007665 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568703007666 putative active site [active] 568703007667 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 568703007668 HPr interaction site; other site 568703007669 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568703007670 active site 568703007671 phosphorylation site [posttranslational modification] 568703007672 Protein of unknown function (DUF1341); Region: DUF1341; pfam07071 568703007673 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568703007674 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703007675 catalytic residue [active] 568703007676 dihydroorotase; Provisional; Region: PRK09237 568703007677 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568703007678 active site 568703007679 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 568703007680 Domain of unknown function (DUF4311); Region: DUF4311; cl11919 568703007681 Domain of unknown function (DUF4312); Region: DUF4312; cl11917 568703007682 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 568703007683 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 568703007684 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 568703007685 HTH domain; Region: HTH_11; pfam08279 568703007686 HTH domain; Region: HTH_11; pfam08279 568703007687 PRD domain; Region: PRD; pfam00874 568703007688 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 568703007689 active site 568703007690 P-loop; other site 568703007691 phosphorylation site [posttranslational modification] 568703007692 Class I aldolases; Region: Aldolase_Class_I; cl17187 568703007693 catalytic residue [active] 568703007694 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 568703007695 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 568703007696 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 568703007697 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 568703007698 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 568703007699 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 568703007700 HTH domain; Region: HTH_11; cl17392 568703007701 HTH domain; Region: HTH_11; pfam08279 568703007702 PRD domain; Region: PRD; pfam00874 568703007703 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 568703007704 active site 568703007705 phosphorylation site [posttranslational modification] 568703007706 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 568703007707 classical (c) SDRs; Region: SDR_c; cd05233 568703007708 NAD(P) binding site [chemical binding]; other site 568703007709 active site 568703007710 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 568703007711 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 568703007712 intersubunit interface [polypeptide binding]; other site 568703007713 active site 568703007714 Zn2+ binding site [ion binding]; other site 568703007715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703007716 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703007717 active site 568703007718 motif I; other site 568703007719 motif II; other site 568703007720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703007721 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 568703007722 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 568703007723 AP (apurinic/apyrimidinic) site pocket; other site 568703007724 DNA interaction; other site 568703007725 Metal-binding active site; metal-binding site 568703007726 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703007727 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 568703007728 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568703007729 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 568703007730 active site 568703007731 dimer interface [polypeptide binding]; other site 568703007732 magnesium binding site [ion binding]; other site 568703007733 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 568703007734 active site 568703007735 P-loop; other site 568703007736 phosphorylation site [posttranslational modification] 568703007737 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 568703007738 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703007739 active site 568703007740 phosphorylation site [posttranslational modification] 568703007741 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 568703007742 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 568703007743 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 568703007744 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 568703007745 catalytic triad [active] 568703007746 putative active site [active] 568703007747 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 568703007748 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 568703007749 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568703007750 nucleotide binding site [chemical binding]; other site 568703007751 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 568703007752 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 568703007753 active site 568703007754 dimer interface [polypeptide binding]; other site 568703007755 catalytic nucleophile [active] 568703007756 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 568703007757 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 568703007758 active site 568703007759 metal binding site [ion binding]; metal-binding site 568703007760 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703007761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703007762 DNA-binding site [nucleotide binding]; DNA binding site 568703007763 UTRA domain; Region: UTRA; pfam07702 568703007764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703007765 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703007766 putative substrate translocation pore; other site 568703007767 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 568703007768 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 568703007769 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 568703007770 D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK; cd07803 568703007771 N- and C-terminal domain interface [polypeptide binding]; other site 568703007772 active site 568703007773 MgATP binding site [chemical binding]; other site 568703007774 catalytic site [active] 568703007775 metal binding site [ion binding]; metal-binding site 568703007776 xylulose binding site [chemical binding]; other site 568703007777 homodimer interface [polypeptide binding]; other site 568703007778 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 568703007779 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 568703007780 NAD(P) binding site [chemical binding]; other site 568703007781 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 568703007782 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 568703007783 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 568703007784 active site 568703007785 phosphorylation site [posttranslational modification] 568703007786 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 568703007787 active pocket/dimerization site; other site 568703007788 active site 568703007789 phosphorylation site [posttranslational modification] 568703007790 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 568703007791 active site 568703007792 phosphorylation site [posttranslational modification] 568703007793 Transposase domain (DUF772); Region: DUF772; pfam05598 568703007794 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 568703007795 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 568703007796 intersubunit interface [polypeptide binding]; other site 568703007797 active site 568703007798 zinc binding site [ion binding]; other site 568703007799 Na+ binding site [ion binding]; other site 568703007800 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 568703007801 putative N- and C-terminal domain interface [polypeptide binding]; other site 568703007802 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 568703007803 putative active site [active] 568703007804 putative MgATP binding site [chemical binding]; other site 568703007805 catalytic site [active] 568703007806 metal binding site [ion binding]; metal-binding site 568703007807 putative carbohydrate binding site [chemical binding]; other site 568703007808 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 568703007809 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568703007810 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 568703007811 active site 568703007812 P-loop; other site 568703007813 phosphorylation site [posttranslational modification] 568703007814 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703007815 active site 568703007816 phosphorylation site [posttranslational modification] 568703007817 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 568703007818 intersubunit interface [polypeptide binding]; other site 568703007819 active site 568703007820 zinc binding site [ion binding]; other site 568703007821 Na+ binding site [ion binding]; other site 568703007822 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703007823 UTRA domain; Region: UTRA; pfam07702 568703007824 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 568703007825 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703007826 Coenzyme A binding pocket [chemical binding]; other site 568703007827 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 568703007828 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 568703007829 nudix motif; other site 568703007830 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 568703007831 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703007832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703007833 non-specific DNA binding site [nucleotide binding]; other site 568703007834 salt bridge; other site 568703007835 sequence-specific DNA binding site [nucleotide binding]; other site 568703007836 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 568703007837 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 568703007838 active site 568703007839 catalytic site [active] 568703007840 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 568703007841 sugar binding site [chemical binding]; other site 568703007842 Cohesin domain, interaction partner of dockerin; Region: Type_III_cohesin_like; cd08759 568703007843 putative dockerin binding interface; other site 568703007844 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 568703007845 nudix motif; other site 568703007846 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 568703007847 Isochorismatase family; Region: Isochorismatase; pfam00857 568703007848 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 568703007849 catalytic triad [active] 568703007850 conserved cis-peptide bond; other site 568703007851 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 568703007852 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 568703007853 active site 568703007854 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 568703007855 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 568703007856 active site 568703007857 catalytic site [active] 568703007858 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 568703007859 Low molecular weight phosphatase family; Region: LMWPc; cd00115 568703007860 active site 568703007861 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568703007862 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568703007863 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568703007864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703007865 dimer interface [polypeptide binding]; other site 568703007866 conserved gate region; other site 568703007867 putative PBP binding loops; other site 568703007868 ABC-ATPase subunit interface; other site 568703007869 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 568703007870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703007871 dimer interface [polypeptide binding]; other site 568703007872 conserved gate region; other site 568703007873 putative PBP binding loops; other site 568703007874 ABC-ATPase subunit interface; other site 568703007875 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 568703007876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568703007877 Walker A/P-loop; other site 568703007878 ATP binding site [chemical binding]; other site 568703007879 Q-loop/lid; other site 568703007880 ABC transporter signature motif; other site 568703007881 Walker B; other site 568703007882 D-loop; other site 568703007883 H-loop/switch region; other site 568703007884 TOBE domain; Region: TOBE_2; pfam08402 568703007885 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703007886 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 568703007887 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568703007888 Beta-lactamase; Region: Beta-lactamase; pfam00144 568703007889 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 568703007890 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 568703007891 putative active site [active] 568703007892 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568703007893 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568703007894 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568703007895 putative active site [active] 568703007896 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 568703007897 active site 568703007898 phosphorylation site [posttranslational modification] 568703007899 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 568703007900 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 568703007901 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 568703007902 putative catalytic site [active] 568703007903 putative metal binding site [ion binding]; other site 568703007904 putative phosphate binding site [ion binding]; other site 568703007905 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 568703007906 DHH family; Region: DHH; pfam01368 568703007907 DHHA1 domain; Region: DHHA1; pfam02272 568703007908 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703007909 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703007910 active site 568703007911 catalytic tetrad [active] 568703007912 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 568703007913 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 568703007914 DNA binding residues [nucleotide binding] 568703007915 putative dimer interface [polypeptide binding]; other site 568703007916 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 568703007917 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 568703007918 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 568703007919 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 568703007920 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568703007921 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 568703007922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703007923 Coenzyme A binding pocket [chemical binding]; other site 568703007924 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 568703007925 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 568703007926 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 568703007927 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 568703007928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703007929 Coenzyme A binding pocket [chemical binding]; other site 568703007930 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 568703007931 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 568703007932 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 568703007933 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 568703007934 transmembrane helices; other site 568703007935 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 568703007936 hypothetical protein; Provisional; Region: PRK06446 568703007937 metal binding site [ion binding]; metal-binding site 568703007938 dimer interface [polypeptide binding]; other site 568703007939 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568703007940 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568703007941 peptide binding site [polypeptide binding]; other site 568703007942 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 568703007943 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703007944 Soluble P-type ATPase [General function prediction only]; Region: COG4087 568703007945 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 568703007946 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 568703007947 putative dimer interface [polypeptide binding]; other site 568703007948 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 568703007949 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 568703007950 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568703007951 protein binding site [polypeptide binding]; other site 568703007952 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 568703007953 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 568703007954 YycH protein; Region: YycI; pfam09648 568703007955 YycH protein; Region: YycH; pfam07435 568703007956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 568703007957 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 568703007958 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568703007959 dimerization interface [polypeptide binding]; other site 568703007960 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568703007961 putative active site [active] 568703007962 heme pocket [chemical binding]; other site 568703007963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568703007964 dimer interface [polypeptide binding]; other site 568703007965 phosphorylation site [posttranslational modification] 568703007966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703007967 ATP binding site [chemical binding]; other site 568703007968 Mg2+ binding site [ion binding]; other site 568703007969 G-X-G motif; other site 568703007970 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703007971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703007972 active site 568703007973 phosphorylation site [posttranslational modification] 568703007974 intermolecular recognition site; other site 568703007975 dimerization interface [polypeptide binding]; other site 568703007976 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568703007977 DNA binding site [nucleotide binding] 568703007978 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568703007979 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 568703007980 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703007981 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703007982 substrate binding pocket [chemical binding]; other site 568703007983 membrane-bound complex binding site; other site 568703007984 hinge residues; other site 568703007985 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703007986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703007987 dimer interface [polypeptide binding]; other site 568703007988 conserved gate region; other site 568703007989 putative PBP binding loops; other site 568703007990 ABC-ATPase subunit interface; other site 568703007991 argininosuccinate synthase; Provisional; Region: PRK13820 568703007992 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 568703007993 ANP binding site [chemical binding]; other site 568703007994 Substrate Binding Site II [chemical binding]; other site 568703007995 Substrate Binding Site I [chemical binding]; other site 568703007996 argininosuccinate lyase; Provisional; Region: PRK00855 568703007997 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 568703007998 active sites [active] 568703007999 tetramer interface [polypeptide binding]; other site 568703008000 Uncharacterized conserved protein [Function unknown]; Region: COG3589 568703008001 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 568703008002 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 568703008003 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 568703008004 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 568703008005 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703008006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703008007 DNA-binding site [nucleotide binding]; DNA binding site 568703008008 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 568703008009 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 568703008010 active site 568703008011 P-loop; other site 568703008012 phosphorylation site [posttranslational modification] 568703008013 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 568703008014 active site 568703008015 methionine cluster; other site 568703008016 phosphorylation site [posttranslational modification] 568703008017 metal binding site [ion binding]; metal-binding site 568703008018 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 568703008019 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 568703008020 Udp N-acetylglucosamine O-acyltransferase; Domain 2; Region: Acetyltransf_11; pfam13720 568703008021 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 568703008022 nudix motif; other site 568703008023 hypothetical protein; Provisional; Region: PRK06762 568703008024 AAA domain; Region: AAA_33; pfam13671 568703008025 Isochorismatase family; Region: Isochorismatase; pfam00857 568703008026 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 568703008027 catalytic triad [active] 568703008028 dimer interface [polypeptide binding]; other site 568703008029 conserved cis-peptide bond; other site 568703008030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703008031 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703008032 putative substrate translocation pore; other site 568703008033 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 568703008034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703008035 putative substrate translocation pore; other site 568703008036 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568703008037 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703008038 active site 568703008039 catalytic tetrad [active] 568703008040 Domain of unknown function (DUF956); Region: DUF956; pfam06115 568703008041 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 568703008042 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 568703008043 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 568703008044 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 568703008045 active pocket/dimerization site; other site 568703008046 active site 568703008047 phosphorylation site [posttranslational modification] 568703008048 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 568703008049 active site 568703008050 phosphorylation site [posttranslational modification] 568703008051 H+ Antiporter protein; Region: 2A0121; TIGR00900 568703008052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703008053 non-specific DNA binding site [nucleotide binding]; other site 568703008054 salt bridge; other site 568703008055 sequence-specific DNA binding site [nucleotide binding]; other site 568703008056 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 568703008057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703008058 non-specific DNA binding site [nucleotide binding]; other site 568703008059 salt bridge; other site 568703008060 sequence-specific DNA binding site [nucleotide binding]; other site 568703008061 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 568703008062 Protein of unknown function (DUF1625); Region: DUF1625; pfam07787 568703008063 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 568703008064 active site 568703008065 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 568703008066 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703008067 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703008068 substrate binding pocket [chemical binding]; other site 568703008069 membrane-bound complex binding site; other site 568703008070 hinge residues; other site 568703008071 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703008072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703008073 dimer interface [polypeptide binding]; other site 568703008074 conserved gate region; other site 568703008075 putative PBP binding loops; other site 568703008076 ABC-ATPase subunit interface; other site 568703008077 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568703008078 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568703008079 Walker A/P-loop; other site 568703008080 ATP binding site [chemical binding]; other site 568703008081 Q-loop/lid; other site 568703008082 ABC transporter signature motif; other site 568703008083 Walker B; other site 568703008084 D-loop; other site 568703008085 H-loop/switch region; other site 568703008086 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568703008087 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568703008088 Protein of unknown function (DUF975); Region: DUF975; cl10504 568703008089 Uncharacterized conserved protein [Function unknown]; Region: COG3402 568703008090 Predicted membrane protein [Function unknown]; Region: COG3428 568703008091 Bacterial PH domain; Region: DUF304; pfam03703 568703008092 Bacterial PH domain; Region: DUF304; pfam03703 568703008093 Predicted ATPase [General function prediction only]; Region: COG3910 568703008094 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 568703008095 Walker A/P-loop; other site 568703008096 ATP binding site [chemical binding]; other site 568703008097 Q-loop/lid; other site 568703008098 ABC transporter signature motif; other site 568703008099 Walker B; other site 568703008100 D-loop; other site 568703008101 H-loop/switch region; other site 568703008102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001 568703008103 Phosphotransferase enzyme family; Region: APH; pfam01636 568703008104 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568703008105 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568703008106 Walker A/P-loop; other site 568703008107 ATP binding site [chemical binding]; other site 568703008108 Q-loop/lid; other site 568703008109 ABC transporter signature motif; other site 568703008110 Walker B; other site 568703008111 D-loop; other site 568703008112 H-loop/switch region; other site 568703008113 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703008114 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703008115 substrate binding pocket [chemical binding]; other site 568703008116 membrane-bound complex binding site; other site 568703008117 hinge residues; other site 568703008118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703008119 dimer interface [polypeptide binding]; other site 568703008120 conserved gate region; other site 568703008121 putative PBP binding loops; other site 568703008122 ABC-ATPase subunit interface; other site 568703008123 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703008124 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568703008125 substrate binding pocket [chemical binding]; other site 568703008126 membrane-bound complex binding site; other site 568703008127 hinge residues; other site 568703008128 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703008129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568703008130 dimer interface [polypeptide binding]; other site 568703008131 conserved gate region; other site 568703008132 putative PBP binding loops; other site 568703008133 ABC-ATPase subunit interface; other site 568703008134 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568703008135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 568703008136 Integral membrane protein DUF95; Region: DUF95; pfam01944 568703008137 MoxR-like ATPases [General function prediction only]; Region: COG0714 568703008138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568703008139 Walker A motif; other site 568703008140 ATP binding site [chemical binding]; other site 568703008141 Walker B motif; other site 568703008142 arginine finger; other site 568703008143 Protein of unknown function DUF58; Region: DUF58; pfam01882 568703008144 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 568703008145 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 568703008146 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 568703008147 putative ADP-binding pocket [chemical binding]; other site 568703008148 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703008149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568703008150 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703008151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 568703008152 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703008153 putative transposase OrfB; Reviewed; Region: PHA02517 568703008154 HTH-like domain; Region: HTH_21; pfam13276 568703008155 Integrase core domain; Region: rve; pfam00665 568703008156 Integrase core domain; Region: rve_2; pfam13333 568703008157 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 568703008158 Aspartase; Region: Aspartase; cd01357 568703008159 active sites [active] 568703008160 tetramer interface [polypeptide binding]; other site 568703008161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 568703008162 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 568703008163 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 568703008164 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 568703008165 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 568703008166 putative NAD(P) binding site [chemical binding]; other site 568703008167 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 568703008168 Malic enzyme, N-terminal domain; Region: malic; pfam00390 568703008169 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 568703008170 PAS domain S-box; Region: sensory_box; TIGR00229 568703008171 PAS domain; Region: PAS; smart00091 568703008172 putative active site [active] 568703008173 heme pocket [chemical binding]; other site 568703008174 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 568703008175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568703008176 active site 568703008177 phosphorylation site [posttranslational modification] 568703008178 intermolecular recognition site; other site 568703008179 dimerization interface [polypeptide binding]; other site 568703008180 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568703008181 Herpesviridae UL52/UL70 DNA primase; Region: Herpes_UL52; cl17300 568703008182 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568703008183 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 568703008184 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 568703008185 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 568703008186 catalytic triad [active] 568703008187 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 568703008188 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 568703008189 Int/Topo IB signature motif; other site 568703008190 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703008191 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703008192 non-specific DNA binding site [nucleotide binding]; other site 568703008193 salt bridge; other site 568703008194 sequence-specific DNA binding site [nucleotide binding]; other site 568703008195 Helix-turn-helix domain; Region: HTH_17; cl17695 568703008196 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 568703008197 polymerase nucleotide-binding site; other site 568703008198 DNA-binding residues [nucleotide binding]; DNA binding site 568703008199 nucleotide binding site [chemical binding]; other site 568703008200 primase nucleotide-binding site [nucleotide binding]; other site 568703008201 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 568703008202 Virulence-associated protein E; Region: VirE; pfam05272 568703008203 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 568703008204 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 568703008205 active site 568703008206 Phage terminase, small subunit; Region: Terminase_4; pfam05119 568703008207 Phage Terminase; Region: Terminase_1; pfam03354 568703008208 Phage portal protein; Region: Phage_portal; pfam04860 568703008209 Phage-related protein [Function unknown]; Region: COG4695; cl01923 568703008210 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 568703008211 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 568703008212 Phage capsid family; Region: Phage_capsid; pfam05065 568703008213 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 568703008214 oligomerization interface [polypeptide binding]; other site 568703008215 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 568703008216 Predicted membrane protein [Function unknown]; Region: COG2261 568703008217 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 568703008218 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 568703008219 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568703008220 active site 568703008221 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568703008222 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 568703008223 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 568703008224 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 568703008225 substrate binding pocket [chemical binding]; other site 568703008226 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 568703008227 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 568703008228 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 568703008229 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 568703008230 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703008231 active site 568703008232 phosphorylation site [posttranslational modification] 568703008233 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 568703008234 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 568703008235 DNA-binding interface [nucleotide binding]; DNA binding site 568703008236 PRD domain; Region: PRD; pfam00874 568703008237 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 568703008238 active site 568703008239 P-loop; other site 568703008240 phosphorylation site [posttranslational modification] 568703008241 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 568703008242 active site 568703008243 phosphorylation site [posttranslational modification] 568703008244 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 568703008245 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 568703008246 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 568703008247 active site 568703008248 P-loop; other site 568703008249 phosphorylation site [posttranslational modification] 568703008250 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 568703008251 active site 568703008252 P-loop; other site 568703008253 phosphorylation site [posttranslational modification] 568703008254 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 568703008255 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 568703008256 active site 568703008257 trimer interface [polypeptide binding]; other site 568703008258 allosteric site; other site 568703008259 active site lid [active] 568703008260 hexamer (dimer of trimers) interface [polypeptide binding]; other site 568703008261 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568703008262 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703008263 active site 568703008264 motif I; other site 568703008265 motif II; other site 568703008266 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703008267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703008268 non-specific DNA binding site [nucleotide binding]; other site 568703008269 salt bridge; other site 568703008270 sequence-specific DNA binding site [nucleotide binding]; other site 568703008271 Domain of unknown function (DUF955); Region: DUF955; cl01076 568703008272 Domain of unknown function (DUF955); Region: DUF955; cl01076 568703008273 HlyD family secretion protein; Region: HlyD_2; pfam12700 568703008274 HlyD family secretion protein; Region: HlyD_3; pfam13437 568703008275 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703008276 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568703008277 Walker A/P-loop; other site 568703008278 ATP binding site [chemical binding]; other site 568703008279 Q-loop/lid; other site 568703008280 ABC transporter signature motif; other site 568703008281 Walker B; other site 568703008282 D-loop; other site 568703008283 H-loop/switch region; other site 568703008284 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568703008285 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 568703008286 FtsX-like permease family; Region: FtsX; pfam02687 568703008287 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 568703008288 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 568703008289 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 568703008290 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 568703008291 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 568703008292 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 568703008293 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 568703008294 transaminase; Reviewed; Region: PRK08068 568703008295 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703008296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703008297 homodimer interface [polypeptide binding]; other site 568703008298 catalytic residue [active] 568703008299 Predicted amidohydrolase [General function prediction only]; Region: COG0388 568703008300 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 568703008301 putative active site [active] 568703008302 catalytic triad [active] 568703008303 putative dimer interface [polypeptide binding]; other site 568703008304 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 568703008305 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 568703008306 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 568703008307 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 568703008308 putative active site [active] 568703008309 metal binding site [ion binding]; metal-binding site 568703008310 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 568703008311 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 568703008312 metal binding site [ion binding]; metal-binding site 568703008313 dimer interface [polypeptide binding]; other site 568703008314 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 568703008315 Uncharacterized conserved protein [Function unknown]; Region: COG2966 568703008316 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 568703008317 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 568703008318 Walker A/P-loop; other site 568703008319 ATP binding site [chemical binding]; other site 568703008320 ABC transporter; Region: ABC_tran; pfam00005 568703008321 Q-loop/lid; other site 568703008322 ABC transporter signature motif; other site 568703008323 Walker B; other site 568703008324 D-loop; other site 568703008325 H-loop/switch region; other site 568703008326 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 568703008327 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 568703008328 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 568703008329 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 568703008330 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 568703008331 trmE is a tRNA modification GTPase; Region: trmE; cd04164 568703008332 G1 box; other site 568703008333 GTP/Mg2+ binding site [chemical binding]; other site 568703008334 Switch I region; other site 568703008335 G2 box; other site 568703008336 Switch II region; other site 568703008337 G3 box; other site 568703008338 G4 box; other site 568703008339 G5 box; other site 568703008340 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 568703008341 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 568703008342 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 568703008343 G-X-X-G motif; other site 568703008344 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 568703008345 RxxxH motif; other site 568703008346 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 568703008347 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 568703008348 ribonuclease P; Reviewed; Region: rnpA; PRK00499 568703008349 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 568703008350 Helix-turn-helix domain; Region: HTH_28; pfam13518 568703008351 Winged helix-turn helix; Region: HTH_29; pfam13551 568703008352 Integrase core domain; Region: rve; pfam00665